IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 11.163
EU - Europa 4.512
AS - Asia 2.323
SA - Sud America 480
AF - Africa 34
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 9
Totale 18.533
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 11.036
CN - Cina 1.065
DE - Germania 937
SE - Svezia 934
RU - Federazione Russa 783
IT - Italia 657
SG - Singapore 634
BR - Brasile 439
GB - Regno Unito 382
VN - Vietnam 358
UA - Ucraina 264
FI - Finlandia 215
CA - Canada 116
FR - Francia 113
ID - Indonesia 62
IE - Irlanda 55
BE - Belgio 41
HK - Hong Kong 41
IN - India 40
AT - Austria 25
NL - Olanda 24
CZ - Repubblica Ceca 21
IR - Iran 19
TR - Turchia 17
AR - Argentina 14
UZ - Uzbekistan 12
AU - Australia 10
JP - Giappone 10
RO - Romania 9
EC - Ecuador 8
EE - Estonia 8
IQ - Iraq 8
PK - Pakistan 7
PL - Polonia 7
BD - Bangladesh 6
EU - Europa 6
KR - Corea 6
ZA - Sudafrica 6
CO - Colombia 5
IL - Israele 5
KG - Kirghizistan 5
LT - Lituania 5
MX - Messico 5
NG - Nigeria 5
PE - Perù 5
CH - Svizzera 4
DZ - Algeria 4
EG - Egitto 4
ES - Italia 4
GE - Georgia 4
KE - Kenya 4
MA - Marocco 4
SA - Arabia Saudita 4
VE - Venezuela 4
AZ - Azerbaigian 3
LV - Lettonia 3
LY - Libia 3
NP - Nepal 3
PT - Portogallo 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AE - Emirati Arabi Uniti 2
AL - Albania 2
BA - Bosnia-Erzegovina 2
BO - Bolivia 2
CL - Cile 2
CR - Costa Rica 2
DK - Danimarca 2
GR - Grecia 2
JO - Giordania 2
KZ - Kazakistan 2
MD - Moldavia 2
NZ - Nuova Zelanda 2
RS - Serbia 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
TN - Tunisia 2
BG - Bulgaria 1
BH - Bahrain 1
DO - Repubblica Dominicana 1
HR - Croazia 1
IM - Isola di Man 1
JM - Giamaica 1
LA - Repubblica Popolare Democratica del Laos 1
MK - Macedonia 1
MN - Mongolia 1
MS - Montserrat 1
MY - Malesia 1
OM - Oman 1
PY - Paraguay 1
SN - Senegal 1
TT - Trinidad e Tobago 1
TW - Taiwan 1
XK - ???statistics.table.value.countryCode.XK??? 1
ZW - Zimbabwe 1
Totale 18.533
Salva come PNG Salva come JPEG
Città #
Fairfield 1.552
Chandler 1.063
Woodbridge 1.045
Houston 734
Ashburn 707
Nyköping 645
Jacksonville 634
Seattle 615
Cambridge 545
Wilmington 531
Ann Arbor 517
Bari 429
Singapore 380
Dong Ket 354
Roxbury 240
Lawrence 234
Nanjing 217
Beijing 213
Boardman 151
Princeton 149
Des Moines 146
New York 141
Brooklyn 114
Montréal 88
Munich 86
San Diego 76
Inglewood 68
Mcallen 68
Shenyang 68
Nanchang 60
Hebei 58
Dublin 54
Dearborn 53
Jiaxing 51
Moscow 49
Jakarta 47
North Bergen 45
London 43
Los Angeles 41
Brussels 39
Paris 38
Tianjin 36
Hong Kong 35
Santa Clara 35
Helsinki 34
São Paulo 33
Nuremberg 31
Redwood City 31
Changsha 28
Shanghai 25
Rome 24
Frankfurt am Main 23
Guangzhou 23
Romola 22
Boydton 21
Brno 19
Pune 18
Toronto 18
Wuhan 18
Jinan 17
Norwalk 17
Augusta 15
Leawood 15
West Jordan 15
Ardabil 14
Council Bluffs 14
Kansas City 14
Belo Horizonte 13
Marseille 13
Rio de Janeiro 13
San Francisco 13
San Mateo 13
Düsseldorf 12
Falkenstein 11
Hefei 11
Taizhou 11
Wuxi 11
Zhengzhou 11
Brasília 10
Ningbo 10
Tashkent 10
Vienna 10
Amsterdam 9
Milan 9
Washington 9
Hounslow 8
Monmouth Junction 8
Indiana 7
Campinas 6
Fuzhou 6
Kilburn 6
Lauterbourg 6
Quanzhou 6
Strasbourg 6
Yiwu 6
Acton 5
Bishkek 5
Curitiba 5
Edinburgh 5
Falls Church 5
Totale 13.272
Salva come PNG Salva come JPEG
Nome #
ABC pumps and their role in active drug transport 370
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 244
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 163
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 159
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 151
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 150
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 148
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 144
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 143
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 139
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 136
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 136
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 136
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 132
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 131
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 130
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 127
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 126
An updated patent review on P-glycoprotein inhibitors (2011-2018) 125
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 125
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 123
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 120
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 120
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 119
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 118
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 116
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 116
Methods and probes for determining the concentration of copper 115
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 114
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 114
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 113
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 112
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 112
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 111
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 110
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 109
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 109
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 109
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 107
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 107
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 107
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 107
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 106
Cyclohexyl-substituted piperazine compounds 106
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 106
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 105
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 105
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 104
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 104
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 104
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 103
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 103
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 103
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 103
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 100
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 100
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 100
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 100
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 98
6,7 Dioxyalkyltetahydroisoquinoline compounds 98
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 97
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 97
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 97
METHOD FOR DETERMINING FREE COPPER 96
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 96
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 94
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 94
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 93
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 93
99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study. 93
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 93
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 93
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 93
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 92
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 92
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 91
Activatable fluorescent probes: a new concept in optical molecular imaging 90
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 89
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 89
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 88
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 88
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 88
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 88
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 87
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 87
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 87
Design and synthesis of new selective P-gp substrates and inhibitors. 86
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 86
The therapeutic potential of 5-HT1A receptors: a patent review. 85
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 85
An innovative small molecule for promoting neuroreparative strategies 85
Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours 84
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 84
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 83
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 83
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 83
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 82
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 82
MC70 potentiates doxorubicin efficay in colon and breast cancer in vitro treatment 82
Non-ceruplasmin copper didtincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency 82
Totale 11.008
Salva come PNG Salva come JPEG
Categoria #
all - tutte 83.672
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.672
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020532 0 0 0 0 0 0 0 0 0 0 355 177
2020/20212.675 234 176 180 162 207 121 207 181 210 301 210 486
2021/20222.072 108 217 57 93 108 174 105 93 153 159 321 484
2022/20232.923 500 336 183 221 389 321 39 345 468 25 48 48
2023/20241.100 91 186 53 83 80 215 23 29 66 42 33 199
2024/20252.887 212 69 378 213 117 339 543 454 286 251 25 0
Totale 19.161