IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 14.135
AS - Asia 5.571
EU - Europa 5.114
SA - Sud America 1.531
AF - Africa 206
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 11
Totale 26.580
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Nazione #
US - Stati Uniti d'America 13.864
SG - Singapore 2.172
CN - Cina 1.510
BR - Brasile 1.316
DE - Germania 1.046
SE - Svezia 964
RU - Federazione Russa 808
IT - Italia 714
HK - Hong Kong 704
VN - Vietnam 653
GB - Regno Unito 485
UA - Ucraina 275
FI - Finlandia 252
CA - Canada 178
FR - Francia 140
IN - India 103
AR - Argentina 96
ID - Indonesia 82
CI - Costa d'Avorio 78
AT - Austria 69
NL - Olanda 65
PL - Polonia 57
IE - Irlanda 56
MX - Messico 52
BD - Bangladesh 50
BE - Belgio 44
JP - Giappone 43
EC - Ecuador 36
ZA - Sudafrica 36
TR - Turchia 35
IQ - Iraq 33
ES - Italia 28
CZ - Repubblica Ceca 24
UZ - Uzbekistan 24
CO - Colombia 21
IR - Iran 21
SA - Arabia Saudita 21
EG - Egitto 18
VE - Venezuela 18
PK - Pakistan 16
LT - Lituania 15
MA - Marocco 15
PY - Paraguay 14
AE - Emirati Arabi Uniti 13
RO - Romania 13
IL - Israele 12
CL - Cile 11
KE - Kenya 11
KR - Corea 11
AU - Australia 10
JO - Giordania 10
TN - Tunisia 10
PE - Perù 9
AZ - Azerbaigian 8
DZ - Algeria 8
EE - Estonia 8
NO - Norvegia 8
CR - Costa Rica 7
GE - Georgia 7
NG - Nigeria 7
EU - Europa 6
KG - Kirghizistan 6
NP - Nepal 6
AL - Albania 5
CH - Svizzera 5
DO - Repubblica Dominicana 5
ET - Etiopia 5
KZ - Kazakistan 5
LY - Libia 5
SN - Senegal 5
TW - Taiwan 5
UY - Uruguay 5
BB - Barbados 4
GR - Grecia 4
RS - Serbia 4
TT - Trinidad e Tobago 4
BO - Bolivia 3
DK - Danimarca 3
GD - Grenada 3
GT - Guatemala 3
LV - Lettonia 3
MD - Moldavia 3
OM - Oman 3
PT - Portogallo 3
TH - Thailandia 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
CY - Cipro 2
GP - Guadalupe 2
HN - Honduras 2
JM - Giamaica 2
MK - Macedonia 2
MN - Mongolia 2
MY - Malesia 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
Totale 26.550
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Città #
Fairfield 1.568
Ashburn 1.182
Dallas 1.168
Chandler 1.063
Woodbridge 1.057
Singapore 1.053
Houston 748
Hong Kong 694
Nyköping 646
Jacksonville 635
Seattle 630
Cambridge 551
Wilmington 538
Ann Arbor 520
Beijing 489
Bari 437
Dong Ket 354
Roxbury 241
Lawrence 235
Nanjing 218
New York 199
Los Angeles 164
Munich 162
Boardman 153
Brooklyn 150
Princeton 150
Des Moines 146
São Paulo 122
Ho Chi Minh City 106
Montréal 88
Buffalo 82
Santa Clara 80
Abidjan 77
San Diego 76
London 73
Hanoi 68
Inglewood 68
Mcallen 68
Shenyang 68
Nanchang 60
Hebei 58
Dublin 56
Dearborn 53
Jakarta 53
Jiaxing 52
Moscow 50
Chicago 46
North Bergen 45
Warsaw 45
Paris 42
Brussels 41
Nuremberg 38
Tianjin 38
Helsinki 37
Frankfurt am Main 36
Rio de Janeiro 36
Tokyo 36
Council Bluffs 33
Turku 33
Vienna 32
Redwood City 31
Toronto 29
Belo Horizonte 28
Changsha 28
Rome 28
Stockholm 28
Atlanta 27
Shanghai 27
Guangzhou 26
Brasília 25
Denver 25
Montreal 25
San Francisco 24
Amsterdam 23
Romola 22
Boston 21
Boydton 21
Tashkent 21
The Dalles 21
Phoenix 20
Pune 20
Brno 19
Falkenstein 19
Groningen 19
Kansas City 19
Wuhan 19
Augusta 18
Curitiba 18
Norwalk 18
Campinas 17
Columbus 17
Jinan 17
Johannesburg 17
Mexico City 17
Haiphong 16
Langenzersdorf 16
Manchester 16
Salvador 16
West Jordan 16
Chennai 15
Totale 17.896
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.057
ABC pumps and their role in active drug transport 398
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 198
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 197
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 192
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 190
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 186
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 185
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 185
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 182
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 180
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 177
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 173
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 172
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 171
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 168
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 166
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 165
An updated patent review on P-glycoprotein inhibitors (2011-2018) 164
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 164
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 163
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 159
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 158
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 155
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 155
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 154
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 150
Methods and probes for determining the concentration of copper 149
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 148
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 148
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 147
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 147
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 147
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 147
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 146
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 145
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 145
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 144
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 143
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 143
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 143
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 141
Cyclohexyl-substituted piperazine compounds 139
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 139
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 138
6,7 Dioxyalkyltetahydroisoquinoline compounds 138
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 137
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 137
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 136
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 136
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 135
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 135
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 134
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 134
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 134
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 132
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 132
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 132
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 131
Activatable fluorescent probes: a new concept in optical molecular imaging 130
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 130
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 130
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 129
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 128
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 128
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 127
METHOD FOR DETERMINING FREE COPPER 126
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 125
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 124
An innovative small molecule for promoting neuroreparative strategies 123
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 123
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 121
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 121
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 121
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 120
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 119
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 119
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 118
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 118
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 118
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 117
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 116
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 115
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 114
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 114
MC70 potentiates doxorubicin efficay in colon and breast cancer in vitro treatment 113
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 112
Non-ceruplasmin copper didtincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency 111
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 110
Measurements of serum non-ceruloplasmin copper by a direct fluorescent methodspecific to Cu(II) 110
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 110
99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study. 109
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 109
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 109
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 108
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 108
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 107
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 107
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 106
Totale 15.057
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Categoria #
all - tutte 110.552
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 110.552
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.727 0 0 0 0 0 123 207 182 210 305 214 486
2021/20222.083 108 222 57 93 108 174 106 93 154 161 321 486
2022/20232.927 502 337 183 221 389 321 39 346 468 25 48 48
2023/20241.102 91 186 53 84 80 215 23 29 66 42 33 200
2024/20254.915 213 69 379 213 117 339 545 454 287 255 707 1.337
2025/20265.963 1.261 693 1.525 1.290 1.049 145 0 0 0 0 0 0
Totale 27.249