IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 10.512
EU - Europa 3.736
AS - Asia 1.895
SA - Sud America 13
OC - Oceania 12
AF - Africa 10
Continente sconosciuto - Info sul continente non disponibili 8
Totale 16.186
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Nazione #
US - Stati Uniti d'America 10.400
CN - Cina 1.022
SE - Svezia 914
DE - Germania 840
IT - Italia 588
SG - Singapore 460
GB - Regno Unito 368
RU - Federazione Russa 330
VN - Vietnam 296
UA - Ucraina 230
FI - Finlandia 209
CA - Canada 110
FR - Francia 89
IE - Irlanda 48
BE - Belgio 40
IN - India 33
CZ - Repubblica Ceca 20
IR - Iran 19
ID - Indonesia 15
NL - Olanda 14
HK - Hong Kong 11
AU - Australia 10
BR - Brasile 9
RO - Romania 9
JP - Giappone 7
PL - Polonia 7
EU - Europa 6
AT - Austria 5
TR - Turchia 5
CH - Svizzera 4
ES - Italia 4
LT - Lituania 4
NG - Nigeria 4
SA - Arabia Saudita 4
KR - Corea 3
LY - Libia 3
PT - Portogallo 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AE - Emirati Arabi Uniti 2
AR - Argentina 2
BD - Bangladesh 2
GE - Georgia 2
NZ - Nuova Zelanda 2
RS - Serbia 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
AZ - Azerbaigian 1
BG - Bulgaria 1
CL - Cile 1
DK - Danimarca 1
DZ - Algeria 1
EG - Egitto 1
GR - Grecia 1
IL - Israele 1
IM - Isola di Man 1
IQ - Iraq 1
JO - Giordania 1
KG - Kirghizistan 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
MN - Mongolia 1
MS - Montserrat 1
MX - Messico 1
MY - Malesia 1
PE - Perù 1
PK - Pakistan 1
TW - Taiwan 1
UZ - Uzbekistan 1
ZW - Zimbabwe 1
Totale 16.186
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Città #
Fairfield 1.491
Chandler 1.008
Woodbridge 972
Houston 695
Ashburn 669
Nyköping 635
Seattle 588
Jacksonville 574
Cambridge 526
Wilmington 514
Ann Arbor 495
Bari 383
Singapore 362
Dong Ket 292
Roxbury 226
Lawrence 221
Beijing 209
Nanjing 206
Boardman 144
Princeton 144
Des Moines 138
New York 138
Brooklyn 111
Montréal 88
Munich 86
San Diego 74
Inglewood 68
Mcallen 68
Shenyang 61
Nanchang 57
Hebei 54
Dearborn 53
Jiaxing 51
Dublin 48
London 41
Brussels 38
Paris 37
Los Angeles 36
Tianjin 34
Redwood City 31
Santa Clara 31
Helsinki 28
Changsha 27
Rome 24
Shanghai 24
Guangzhou 22
Boydton 21
Romola 21
Brno 20
Frankfurt am Main 18
Wuhan 18
Jinan 16
Norwalk 16
Pune 16
Augusta 15
Leawood 15
Toronto 15
West Jordan 15
Ardabil 14
Kansas City 14
San Mateo 13
Marseille 12
San Francisco 12
Wuxi 12
Hefei 11
Taizhou 11
Zhengzhou 11
Ningbo 9
Washington 9
Hounslow 8
Indiana 7
Monmouth Junction 7
Amsterdam 6
Fuzhou 6
Kilburn 6
Milan 6
Nuremberg 6
Quanzhou 6
Strasbourg 6
Acton 5
Edinburgh 5
Falls Church 5
Hong Kong 5
Jinhua 5
Kunming 5
Sannicandro di Bari 5
Vienna 5
Yiwu 5
Catania 4
Chengdu 4
Chiswick 4
Grafing 4
Hanoi 4
Lagos 4
Ottawa 4
Philadelphia 4
Riyadh 4
Sydney 4
Acquaviva delle Fonti 3
Baotou 3
Totale 12.311
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Nome #
ABC pumps and their role in active drug transport 360
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 227
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 153
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 152
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 134
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 134
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 133
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 133
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 132
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 129
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 129
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 125
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 124
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 124
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 123
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 120
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 118
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 116
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 116
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 114
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 113
An updated patent review on P-glycoprotein inhibitors (2011-2018) 112
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 111
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 111
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 110
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 109
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 107
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 106
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 105
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 105
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 103
Methods and probes for determining the concentration of copper 102
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 102
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 102
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 102
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 101
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 101
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 101
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 100
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 100
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 99
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 99
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 98
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 98
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 98
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 97
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 97
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 96
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 96
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 96
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 96
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 95
Cyclohexyl-substituted piperazine compounds 94
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 94
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 93
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 93
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 92
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 91
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 91
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 90
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 89
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 88
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 88
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 88
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 87
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 87
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 87
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 86
Activatable fluorescent probes: a new concept in optical molecular imaging 86
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 86
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 86
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 86
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 85
METHOD FOR DETERMINING FREE COPPER 85
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 84
The therapeutic potential of 5-HT1A receptors: a patent review. 84
6,7 Dioxyalkyltetahydroisoquinoline compounds 84
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 83
Design and synthesis of new selective P-gp substrates and inhibitors. 83
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 83
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 82
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 82
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 81
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 81
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 81
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 81
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 81
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 80
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 80
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 80
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 78
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 77
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 77
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 77
An innovative small molecule for promoting neuroreparative strategies 77
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 77
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 76
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 76
Is the sigma-2 receptor a histone binding protein? 76
Totale 10.228
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Categoria #
all - tutte 72.397
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 72.397
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.284 0 0 0 0 0 248 400 356 445 320 342 173
2020/20212.525 224 170 173 159 194 119 200 173 200 286 208 419
2021/20221.987 106 209 55 84 105 166 104 88 146 154 310 460
2022/20232.802 477 329 177 205 375 312 38 329 446 23 46 45
2023/20241.063 86 183 52 81 79 208 23 21 60 41 31 198
2024/20251.265 210 66 358 209 117 305 0 0 0 0 0 0
Totale 16.787