IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 10.252
EU - Europa 3.340
AS - Asia 1.162
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 8
SA - Sud America 6
AF - Africa 5
Totale 14.785
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Nazione #
US - Stati Uniti d'America 10.152
SE - Svezia 914
DE - Germania 803
CN - Cina 765
IT - Italia 497
GB - Regno Unito 359
VN - Vietnam 296
UA - Ucraina 230
FI - Finlandia 202
RU - Federazione Russa 117
CA - Canada 98
FR - Francia 85
IE - Irlanda 47
BE - Belgio 40
IN - India 33
IR - Iran 19
ID - Indonesia 15
AU - Australia 10
RO - Romania 9
NL - Olanda 8
PL - Polonia 7
EU - Europa 6
HK - Hong Kong 6
JP - Giappone 6
TR - Turchia 5
BR - Brasile 3
CZ - Repubblica Ceca 3
LY - Libia 3
PT - Portogallo 3
SG - Singapore 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AT - Austria 2
CH - Svizzera 2
ES - Italia 2
KR - Corea 2
NZ - Nuova Zelanda 2
RS - Serbia 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
AE - Emirati Arabi Uniti 1
AR - Argentina 1
BG - Bulgaria 1
CL - Cile 1
DK - Danimarca 1
EG - Egitto 1
GE - Georgia 1
GR - Grecia 1
IL - Israele 1
IM - Isola di Man 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
MN - Mongolia 1
MS - Montserrat 1
MX - Messico 1
MY - Malesia 1
PE - Perù 1
PK - Pakistan 1
ZW - Zimbabwe 1
Totale 14.785
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Città #
Fairfield 1.491
Chandler 1.014
Woodbridge 972
Houston 695
Ashburn 655
Nyköping 635
Seattle 588
Jacksonville 574
Cambridge 526
Wilmington 514
Ann Arbor 495
Bari 359
Dong Ket 292
Roxbury 226
Lawrence 221
Nanjing 206
Beijing 190
Princeton 144
Des Moines 138
New York 138
Brooklyn 111
Montréal 88
Boardman 77
San Diego 74
Inglewood 68
Mcallen 68
Munich 65
Shenyang 60
Nanchang 57
Hebei 54
Dearborn 53
Dublin 47
Jiaxing 41
Brussels 38
Paris 36
London 34
Tianjin 33
Redwood City 31
Changsha 24
Los Angeles 22
Boydton 21
Helsinki 21
Rome 19
Jinan 16
Norwalk 16
Pune 16
Augusta 15
Leawood 15
West Jordan 15
Ardabil 14
Kansas City 14
San Mateo 13
Frankfurt am Main 12
Marseille 12
San Francisco 12
Hefei 11
Ningbo 9
Taizhou 9
Washington 9
Zhengzhou 9
Hounslow 8
Indiana 7
Monmouth Junction 7
Toronto 7
Fuzhou 6
Guangzhou 6
Kilburn 6
Milan 6
Strasbourg 6
Acton 5
Edinburgh 5
Falls Church 5
Kunming 5
Sannicandro di Bari 5
Chengdu 4
Chiswick 4
Grafing 4
Hanoi 4
Sydney 4
Acquaviva delle Fonti 3
Baotou 3
Bremen 3
Brno 3
Detroit 3
Noci 3
Auburn Hills 2
Auckland 2
Aveiro 2
Bangkok 2
Belgrade 2
Bergamo 2
Boston 2
Canberra 2
Catania 2
Central 2
Chicago 2
Focsani 2
Hanover 2
Islington 2
Krakow 2
Totale 11.584
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Nome #
ABC pumps and their role in active drug transport 355
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 203
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 146
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 139
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 130
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 127
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 125
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 124
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 123
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 121
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 121
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 120
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 119
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 114
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 112
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 111
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 109
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 109
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 108
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 107
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 106
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 104
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 103
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 103
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 101
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 101
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 101
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 101
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 100
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 98
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 98
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 97
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 97
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 96
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 95
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 95
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 94
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 93
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 93
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 93
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 93
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 92
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 92
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 91
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 91
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 91
Methods and probes for determining the concentration of copper 90
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 89
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 89
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 88
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 88
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 88
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 87
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 86
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 86
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 84
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 84
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 84
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 84
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 84
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 83
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 83
The therapeutic potential of 5-HT1A receptors: a patent review. 82
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 82
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 81
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 81
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 80
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 80
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 79
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 79
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 79
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 79
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 79
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 79
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 79
An updated patent review on P-glycoprotein inhibitors (2011-2018) 79
Activatable fluorescent probes: a new concept in optical molecular imaging 78
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 78
Design and synthesis of new selective P-gp substrates and inhibitors. 78
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 78
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 77
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 77
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 77
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 76
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 76
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 76
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 75
6,7 Dioxyalkyltetahydroisoquinoline compounds 73
METHOD FOR DETERMINING FREE COPPER 73
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 73
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 73
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 72
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 72
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 72
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 71
Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity. 71
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 71
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 70
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 69
Totale 9.515
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Categoria #
all - tutte 58.144
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 58.144
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019912 0 0 0 0 0 0 0 0 0 0 456 456
2019/20203.925 652 181 128 327 353 248 400 356 445 320 342 173
2020/20212.525 224 170 173 159 194 119 200 173 200 286 208 419
2021/20221.987 106 209 55 84 105 166 104 88 146 154 310 460
2022/20232.812 477 329 177 207 377 313 38 332 448 23 46 45
2023/2024838 87 183 53 82 79 208 23 22 60 41 0 0
Totale 15.307