IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 16.269
AS - Asia 6.959
EU - Europa 6.959
SA - Sud America 1.859
AF - Africa 305
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 11
Totale 32.376
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Nazione #
US - Stati Uniti d'America 15.875
SG - Singapore 2.616
IT - Italia 1.953
CN - Cina 1.678
BR - Brasile 1.495
DE - Germania 1.093
SE - Svezia 978
RU - Federazione Russa 828
VN - Vietnam 801
HK - Hong Kong 754
GB - Regno Unito 520
FR - Francia 402
FI - Finlandia 366
UA - Ucraina 285
CA - Canada 227
IN - India 199
BD - Bangladesh 186
AR - Argentina 151
ID - Indonesia 109
NL - Olanda 86
MX - Messico 84
CI - Costa d'Avorio 80
IQ - Iraq 80
AT - Austria 70
JP - Giappone 69
PL - Polonia 69
TR - Turchia 62
IE - Irlanda 57
PK - Pakistan 57
ZA - Sudafrica 56
EC - Ecuador 55
SA - Arabia Saudita 52
CO - Colombia 51
UZ - Uzbekistan 48
BE - Belgio 47
ES - Italia 41
VE - Venezuela 38
MA - Marocco 31
EG - Egitto 30
PH - Filippine 26
CZ - Repubblica Ceca 25
NO - Norvegia 25
TN - Tunisia 23
JO - Giordania 22
IR - Iran 21
CL - Cile 20
KE - Kenya 20
MY - Malesia 20
AE - Emirati Arabi Uniti 17
PY - Paraguay 17
CR - Costa Rica 16
KR - Corea 16
LT - Lituania 16
AZ - Azerbaigian 15
NP - Nepal 15
IL - Israele 14
RO - Romania 14
PE - Perù 13
DZ - Algeria 12
JM - Giamaica 11
NG - Nigeria 11
AU - Australia 10
BO - Bolivia 10
GT - Guatemala 10
LY - Libia 10
CH - Svizzera 9
EE - Estonia 9
ET - Etiopia 9
KG - Kirghizistan 9
KZ - Kazakistan 9
GE - Georgia 8
LB - Libano 8
TH - Thailandia 8
OM - Oman 7
PS - Palestinian Territory 7
RS - Serbia 7
SN - Senegal 7
TT - Trinidad e Tobago 7
AL - Albania 6
EU - Europa 6
MD - Moldavia 6
SK - Slovacchia (Repubblica Slovacca) 6
TW - Taiwan 6
UY - Uruguay 6
BG - Bulgaria 5
DK - Danimarca 5
DO - Repubblica Dominicana 5
GD - Grenada 5
GR - Grecia 5
HU - Ungheria 5
PA - Panama 5
SY - Repubblica araba siriana 5
BB - Barbados 4
LV - Lettonia 4
MN - Mongolia 4
NI - Nicaragua 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
BH - Bahrain 3
HN - Honduras 3
Totale 32.318
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Città #
Fairfield 1.568
Ashburn 1.392
Singapore 1.373
Dallas 1.183
Chandler 1.063
Woodbridge 1.059
San Jose 870
Houston 758
Hong Kong 744
Nyköping 646
Jacksonville 639
Milan 633
Seattle 633
Cambridge 552
Wilmington 540
Ann Arbor 520
Beijing 509
Bari 450
Dong Ket 354
Lauterbourg 249
New York 245
Roxbury 241
Lawrence 235
Nanjing 218
Rome 210
Boardman 201
Los Angeles 193
Munich 162
Brooklyn 156
Helsinki 151
Princeton 150
Des Moines 149
São Paulo 142
Ho Chi Minh City 140
Santa Clara 121
Hanoi 104
Buffalo 94
Montréal 88
Council Bluffs 86
Columbus 84
Abidjan 79
London 78
San Diego 78
Shenyang 69
Inglewood 68
Mcallen 68
Nanchang 60
Tokyo 59
Hebei 58
Dublin 57
Jakarta 56
Chicago 55
Warsaw 54
Dearborn 53
Frankfurt am Main 53
Moscow 53
Jiaxing 52
Figino 49
North Bergen 48
Rio de Janeiro 45
Atlanta 44
Paris 44
Falkenstein 43
Brussels 42
Stockholm 42
Tashkent 42
Tianjin 40
Nuremberg 39
Toronto 39
Montreal 38
Orem 38
Denver 37
Amsterdam 35
Turin 35
Turku 33
Vienna 33
Belo Horizonte 32
Redwood City 31
The Dalles 31
Shanghai 30
Baghdad 28
Changsha 28
Guangzhou 28
Naples 28
Phoenix 28
Brasília 27
Curitiba 25
San Francisco 25
Boston 24
Campinas 23
Florence 23
Mexico City 23
Haiphong 22
Manchester 22
Pune 22
Romola 22
Boydton 21
Chennai 21
Dhaka 21
Kansas City 21
Totale 21.327
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.114
ABC pumps and their role in active drug transport 412
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 238
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 233
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 229
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 222
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 219
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 219
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 214
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 213
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 211
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 204
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 200
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 197
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 192
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 190
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 190
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 189
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 189
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 188
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 184
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 183
An updated patent review on P-glycoprotein inhibitors (2011-2018) 183
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 179
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 177
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 177
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 176
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 176
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 175
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 175
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 173
Methods and probes for determining the concentration of copper 172
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 172
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 172
Cyclohexyl-substituted piperazine compounds 171
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 171
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 170
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 170
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 169
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 167
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 167
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 165
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 165
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 165
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 164
6,7 Dioxyalkyltetahydroisoquinoline compounds 164
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 164
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 164
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 163
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 162
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 160
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 160
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 159
METHOD FOR DETERMINING FREE COPPER 158
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 158
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 157
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 156
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 155
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 154
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 154
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 153
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 153
Activatable fluorescent probes: a new concept in optical molecular imaging 152
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 152
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 151
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 149
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 148
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 147
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 147
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 146
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 146
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 146
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 145
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 145
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 145
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 143
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 143
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 142
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 142
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 141
An innovative small molecule for promoting neuroreparative strategies 141
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 139
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 139
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 139
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 137
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 134
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 134
MC70 potentiates doxorubicin efficay in colon and breast cancer in vitro treatment 133
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 132
Non-ceruplasmin copper didtincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency 132
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 132
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 131
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 129
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 129
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 129
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 129
Measurements of serum non-ceruloplasmin copper by a direct fluorescent methodspecific to Cu(II) 128
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease 128
99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study. 127
Totale 17.587
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Categoria #
all - tutte 127.422
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 127.422
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.083 108 222 57 93 108 174 106 93 154 161 321 486
2022/20232.927 502 337 183 221 389 321 39 346 468 25 48 48
2023/20241.102 91 186 53 84 80 215 23 29 66 42 33 200
2024/20254.915 213 69 379 213 117 339 545 454 287 255 707 1.337
2025/202611.537 1.261 693 1.525 1.290 1.049 605 1.180 291 963 1.025 401 1.254
2026/2027225 225 0 0 0 0 0 0 0 0 0 0 0
Totale 33.048