IRIS
COLABUFO, Nicola Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 16.033
AS - Asia 6.917
EU - Europa 5.896
SA - Sud America 1.845
AF - Africa 304
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 11
Totale 31.020
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Nazione #
US - Stati Uniti d'America 15.659
SG - Singapore 2.612
CN - Cina 1.672
BR - Brasile 1.488
DE - Germania 1.093
SE - Svezia 978
IT - Italia 899
RU - Federazione Russa 828
VN - Vietnam 800
HK - Hong Kong 754
GB - Regno Unito 520
FR - Francia 399
FI - Finlandia 366
UA - Ucraina 285
CA - Canada 218
IN - India 199
BD - Bangladesh 155
AR - Argentina 151
ID - Indonesia 109
MX - Messico 84
NL - Olanda 84
CI - Costa d'Avorio 80
IQ - Iraq 80
AT - Austria 70
JP - Giappone 69
PL - Polonia 69
TR - Turchia 62
IE - Irlanda 57
PK - Pakistan 57
ZA - Sudafrica 56
EC - Ecuador 54
SA - Arabia Saudita 52
UZ - Uzbekistan 48
BE - Belgio 47
CO - Colombia 45
ES - Italia 40
VE - Venezuela 38
MA - Marocco 31
EG - Egitto 30
PH - Filippine 26
CZ - Repubblica Ceca 25
NO - Norvegia 25
TN - Tunisia 23
JO - Giordania 22
IR - Iran 21
CL - Cile 20
KE - Kenya 20
MY - Malesia 20
AE - Emirati Arabi Uniti 17
PY - Paraguay 17
KR - Corea 16
LT - Lituania 16
AZ - Azerbaigian 15
CR - Costa Rica 15
NP - Nepal 15
IL - Israele 14
PE - Perù 13
RO - Romania 13
DZ - Algeria 12
NG - Nigeria 11
AU - Australia 10
BO - Bolivia 10
LY - Libia 10
CH - Svizzera 9
EE - Estonia 9
ET - Etiopia 9
JM - Giamaica 9
KG - Kirghizistan 9
KZ - Kazakistan 9
GE - Georgia 8
GT - Guatemala 8
LB - Libano 8
TH - Thailandia 8
OM - Oman 7
PS - Palestinian Territory 7
RS - Serbia 7
SN - Senegal 7
AL - Albania 6
EU - Europa 6
SK - Slovacchia (Repubblica Slovacca) 6
TW - Taiwan 6
UY - Uruguay 6
BG - Bulgaria 5
DK - Danimarca 5
DO - Repubblica Dominicana 5
GD - Grenada 5
GR - Grecia 5
MD - Moldavia 5
PA - Panama 5
SY - Repubblica araba siriana 5
TT - Trinidad e Tobago 5
BB - Barbados 4
HU - Ungheria 4
LV - Lettonia 4
MN - Mongolia 4
NZ - Nuova Zelanda 4
PT - Portogallo 4
BH - Bahrain 3
NI - Nicaragua 3
A2 - ???statistics.table.value.countryCode.A2??? 2
Totale 30.965
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Città #
Fairfield 1.568
Ashburn 1.374
Singapore 1.371
Dallas 1.182
Chandler 1.063
Woodbridge 1.059
San Jose 858
Houston 755
Hong Kong 744
Nyköping 646
Jacksonville 638
Seattle 633
Cambridge 552
Wilmington 538
Ann Arbor 520
Beijing 508
Bari 443
Dong Ket 354
Lauterbourg 249
New York 242
Roxbury 241
Lawrence 235
Nanjing 218
Boardman 201
Los Angeles 191
Munich 162
Brooklyn 154
Helsinki 151
Princeton 150
Des Moines 149
São Paulo 141
Ho Chi Minh City 139
Santa Clara 109
Hanoi 104
Buffalo 91
Montréal 88
Council Bluffs 85
Abidjan 79
London 78
San Diego 78
Shenyang 69
Inglewood 68
Mcallen 68
Nanchang 60
Tokyo 59
Hebei 58
Dublin 57
Jakarta 56
Chicago 54
Warsaw 54
Dearborn 53
Frankfurt am Main 53
Moscow 53
Jiaxing 52
North Bergen 47
Rio de Janeiro 45
Paris 44
Falkenstein 43
Atlanta 42
Brussels 42
Stockholm 42
Tashkent 42
Rome 41
Tianjin 40
Nuremberg 39
Orem 38
Denver 37
Montreal 37
Toronto 37
Amsterdam 35
Turku 33
Vienna 33
Belo Horizonte 32
Redwood City 31
Baghdad 28
Changsha 28
Guangzhou 28
Shanghai 28
Brasília 27
Phoenix 27
The Dalles 27
Milan 25
San Francisco 25
Boston 24
Curitiba 23
Mexico City 23
Campinas 22
Haiphong 22
Manchester 22
Pune 22
Romola 22
Boydton 21
Chennai 21
Dhaka 21
Kansas City 21
Augusta 20
Bjørkelangen 20
Groningen 20
Johannesburg 20
Amman 19
Totale 20.341
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.099
ABC pumps and their role in active drug transport 411
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 230
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 220
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 217
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 216
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 212
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 211
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 208
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 207
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 206
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 200
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 194
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 190
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography 185
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 184
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 183
An updated patent review on P-glycoprotein inhibitors (2011-2018) 182
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 181
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 181
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 180
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 179
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 175
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 173
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 172
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 172
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 171
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier 169
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 166
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 166
Methods and probes for determining the concentration of copper 165
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 165
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 164
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 164
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study 164
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 164
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 162
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 162
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 162
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 162
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 161
Cyclohexyl-substituted piperazine compounds 161
6,7 Dioxyalkyltetahydroisoquinoline compounds 160
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 160
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 159
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 158
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 157
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 155
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 155
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 154
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 153
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 152
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 152
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 151
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 151
METHOD FOR DETERMINING FREE COPPER 151
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 151
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 151
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 148
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 148
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 147
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 146
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 146
Activatable fluorescent probes: a new concept in optical molecular imaging 145
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 145
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 144
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 143
An innovative small molecule for promoting neuroreparative strategies 141
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 141
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 141
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 140
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 138
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 138
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 138
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 138
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 138
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 137
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 136
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 136
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 135
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 134
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 133
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 133
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 131
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 130
MC70 potentiates doxorubicin efficay in colon and breast cancer in vitro treatment 128
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 127
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 127
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 126
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease 126
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 124
Non-ceruplasmin copper didtincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency 124
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 123
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 123
99mTc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study. 122
Measurements of serum non-ceruloplasmin copper by a direct fluorescent methodspecific to Cu(II) 121
Totale 17.012
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Categoria #
all - tutte 122.545
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 122.545
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021486 0 0 0 0 0 0 0 0 0 0 0 486
2021/20222.083 108 222 57 93 108 174 106 93 154 161 321 486
2022/20232.927 502 337 183 221 389 321 39 346 468 25 48 48
2023/20241.102 91 186 53 84 80 215 23 29 66 42 33 200
2024/20254.915 213 69 379 213 117 339 545 454 287 255 707 1.337
2025/202610.405 1.261 693 1.525 1.290 1.049 605 1.180 291 963 1.025 401 122
Totale 31.691