Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum
COLABUFO, Nicola Antonio;BERARDI, Francesco;CONTINO, MARIALESSANDRA;INGLESE, CARMELA;NISO, MAURO;PERRONE, Roberto
2008-01-01
Abstract
Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC(50)=14.7 microM), Cyclosporin A and Tamoxifen displayed EC(50)=25.2 and 39.4 microM, respectively.File in questo prodotto:
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