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The Conundrum of Dystonia in Essential Tremor Patients: How does One Classify these Cases?

Background: The relationship between essential tremor (ET) and dystonia has been long debated and the boundaries between these disorders remain unclear. Here, we highlight the diagnostic uncertainty that can arise when observing dystonic postures in patients who have received ET diagnoses.Methods: An international panel of seven movement disorders neurologists from five countries reviewed the clinical history and videotaped neurological examinations of five individuals diagnosed with ET who a...

Assessment of C Fibers Evoked Potentials in Healthy Subjects by Nd : YAP Laser

Introduction. Although laser stimuli activate both Ad- and C-fibres, the corresponding laser evoked potentials (LEPs) remain restricted to the Ad-fibers input, while the C-fibers related potential is hardly detectable. Aims. To evaluate multichannel ultralate LEPs (U-LEPs) by using Nd : Yap laser pulses in healthy volunteers to stimulation of face and lower and upper limbs, in order to estimate the reliability of C-LEPs elicited from both trigeminal and somatic sites. Methods. Twenty healthy ...

Neurological phenomenology of the IRF2BPL mutation syndrome: Analysis of a new case and systematic review of the literature

Background: IRF2BPL is an intronless gene that was mapped to 14q24.3 chromosome in 2000 and codes for the interferon regulatory factor 2 binding like protein.Objective: To analyses the clinical characteristics of the patients reported in the literature and of an additional patient we observed in order to better delineate the phenomenological spectrum of the disease and provide indications to improve clinical recognition and facilitate diagnosis.Methods: We reported on 28 patients carrying the...

Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease

Purpose: Altered serotonergic neurotransmission may contribute to the non-motor features commonly associated with Parkinson’s disease (PD) such as sleep disorders. The 5-hydroxytryptophan (5-HTP) is the intermediate metabolite of l-tryptophan in the production of serotonin and melatonin. The purpose of this study was to compare the effects of 5-HTP to placebo on REM sleep behavior disorder (RBD) status in patients with PD. Methods: A single-center, randomized, double-blind placebo-controlled ...

Presbyphagia: the importance of an early diagnosis in the aging population

Objectives. The aim of our study was to use the DRAS (Dysphagia Risk Assessment Scale) questionnaire in order to identify the percentage of the population over the age of 65 with unrecognized symptoms of dysphagia. Materials and methods. The DRAS questionnaire was administered to a group of 100 subjects over or equal to 65 years old. The same questionnaire was administered to a group of 50 healthy control individuals. All patients underwent fiberoptic endoscopic evaluation of swallowing (FEES...

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Prodotti recenti

The Conundrum of Dystonia in Essential Tremor Patients: How does One Classify these Cases?

Assessment of C Fibers Evoked Potentials in Healthy Subjects by Nd : YAP Laser

Neurological phenomenology of the IRF2BPL mutation syndrome: Analysis of a new case and systematic review of the literature

Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease

Presbyphagia: the importance of an early diagnosis in the aging population

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