| Nome |
# |
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Evaluation of [18F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity., file dd9e0c64-10e9-1e9c-e053-3a05fe0a45ef
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217
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The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders, file d5e825ac-71b9-4343-ab1b-ba913fddc5b7
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132
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Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation, file dd9e0c67-3dcd-1e9c-e053-3a05fe0a45ef
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123
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Copper dyshomeostasis in Wilson disease and Alzheimer's disease as shown by serum and urine copper indicators., file 8b01fb2a-fade-4cc7-b21d-f119d3169442
|
115
|
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Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies, file 400270d7-9caf-491c-9c10-1978d408721f
|
100
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P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study, file dd9e0c63-a64d-1e9c-e053-3a05fe0a45ef
|
90
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Automated synthesis, preclinical toxicity, and radiation dosimetry of [18F]MC225 for clinical use: a tracer for measuring Pglycoprotein function at the blood-brain barrier, file dd9e0c68-bc28-1e9c-e053-3a05fe0a45ef
|
77
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Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation, file dd9e0c64-37c1-1e9c-e053-3a05fe0a45ef
|
74
|
|
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes, file dd9e0c67-4044-1e9c-e053-3a05fe0a45ef
|
68
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|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c6c-8224-1e9c-e053-3a05fe0a45ef
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61
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Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine, file dd9e0c64-ff31-1e9c-e053-3a05fe0a45ef
|
60
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Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators, file 584005b4-55e0-4b5d-b957-970cde0dcd02
|
44
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Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier, file e79ee32e-92c6-4fd9-bc50-fa35477721ea
|
44
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Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells, file dd9e0c67-243c-1e9c-e053-3a05fe0a45ef
|
43
|
|
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers, file dd9e0c66-c0e4-1e9c-e053-3a05fe0a45ef
|
39
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Comparison of in vitro assay in selecting radiotracers for in vivo P-glycoprotein PET imaging, file dd9e0c64-d1d1-1e9c-e053-3a05fe0a45ef
|
35
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A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells, file 01360d3a-9bcc-4801-8e98-d0b60627060b
|
26
|
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Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells., file a55cd1af-f730-4c06-ae4c-3471ef84cc01
|
23
|
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Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels, file dd9e0c6b-45e6-1e9c-e053-3a05fe0a45ef
|
15
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Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2, file b57f7f96-4a54-4f55-8aff-9a6c9209a91d
|
12
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A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents, file dd9e0c63-a7e0-1e9c-e053-3a05fe0a45ef
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12
|
|
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c6c-84df-1e9c-e053-3a05fe0a45ef
|
9
|
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Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules, file dd9e0c62-f60d-1e9c-e053-3a05fe0a45ef
|
8
|
|
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease, file dd9e0c68-f63e-1e9c-e053-3a05fe0a45ef
|
8
|
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Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and p-glycoprotein, file dd9e0c63-a35a-1e9c-e053-3a05fe0a45ef
|
7
|
|
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators, file dd9e0c65-b10e-1e9c-e053-3a05fe0a45ef
|
6
|
|
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein, file dd9e0c67-3682-1e9c-e053-3a05fe0a45ef
|
6
|
|
Head-to-head comparison of (R)-[11C]verapamil and [18F]MC225 in non-human primates, tracers for measuring P-glycoprotein function, file dd9e0c6b-37a1-1e9c-e053-3a05fe0a45ef
|
6
|
|
LC–MS/MS Analysis on Infusion Bags and Filled Syringes of Decitabine: New Data on Physicochemical Stability of an Unstable Molecule, file 67c1933f-0286-4b2e-99e3-1d79135f2189
|
5
|
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11C- and 18F-Labeled Radioligands for P-Glycoprotein Imaging by Positron Emission Tomography, file dd9e0c62-ff05-1e9c-e053-3a05fe0a45ef
|
5
|
|
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE, file dd9e0c63-a000-1e9c-e053-3a05fe0a45ef
|
5
|
|
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity, file dd9e0c63-c566-1e9c-e053-3a05fe0a45ef
|
4
|
|
Non-ceruplasmin copper didtincts subtypes in Alzheimer's disease: a genetic study of ATP7B frequency, file dd9e0c63-e00e-1e9c-e053-3a05fe0a45ef
|
4
|
|
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle, file dd9e0c64-30ad-1e9c-e053-3a05fe0a45ef
|
4
|
|
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies, file dd9e0c64-baf6-1e9c-e053-3a05fe0a45ef
|
4
|
|
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET., file dd9e0c64-ecb9-1e9c-e053-3a05fe0a45ef
|
4
|
|
null, file dd9e0c65-df4a-1e9c-e053-3a05fe0a45ef
|
4
|
|
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide., file dd9e0c66-e345-1e9c-e053-3a05fe0a45ef
|
4
|
|
Amyloid binding and beyond: a new approach for Alzheimer's disease drug discovery targeting Abo–PrPC binding and downstream pathways, file dd9e0c6b-3c24-1e9c-e053-3a05fe0a45ef
|
4
|
|
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities?, file dd9e0c62-d23a-1e9c-e053-3a05fe0a45ef
|
3
|
|
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c63-b970-1e9c-e053-3a05fe0a45ef
|
3
|
|
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump, file dd9e0c64-0e08-1e9c-e053-3a05fe0a45ef
|
3
|
|
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics, file dd9e0c64-4f16-1e9c-e053-3a05fe0a45ef
|
3
|
|
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line, file dd9e0c64-8896-1e9c-e053-3a05fe0a45ef
|
3
|
|
Copper dyshomeostasis in Wilson disease and Alzheimer's disease as shown by serum and urine copper indicators., file dd9e0c64-cb80-1e9c-e053-3a05fe0a45ef
|
3
|
|
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders, file dd9e0c64-fbc8-1e9c-e053-3a05fe0a45ef
|
3
|
|
An innovative small molecule for promoting neuroreparative strategies, file dd9e0c66-d1cc-1e9c-e053-3a05fe0a45ef
|
3
|
|
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells., file dd9e0c67-212b-1e9c-e053-3a05fe0a45ef
|
3
|
|
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2, file dd9e0c67-2999-1e9c-e053-3a05fe0a45ef
|
3
|
|
Evaluation of P-glycoprotein function at the blood-brain barrier using [ 18 F]MC225-PET, file dd9e0c6b-59a6-1e9c-e053-3a05fe0a45ef
|
3
|
|
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells, file 47eadb1f-307e-420a-81c6-b6a5887d7cf0
|
2
|
|
Design and synthesis of new selective P-gp substrates and inhibitors., file dd9e0c63-e087-1e9c-e053-3a05fe0a45ef
|
2
|
|
Measurements of serum non-ceruloplasmin copper by a direct fluorescent methodspecific to Cu(II), file dd9e0c64-9421-1e9c-e053-3a05fe0a45ef
|
2
|
|
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents, file dd9e0c65-3b08-1e9c-e053-3a05fe0a45ef
|
2
|
|
An updated patent review on P-glycoprotein inhibitors (2011-2018), file dd9e0c66-d4d0-1e9c-e053-3a05fe0a45ef
|
2
|
|
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R), file dd9e0c67-09fb-1e9c-e053-3a05fe0a45ef
|
2
|
|
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands, file dd9e0c67-2610-1e9c-e053-3a05fe0a45ef
|
2
|
|
Synthesis and Preclinical Evaluation of Three Novel Fluorine-18 Labeled Radiopharmaceuticals for P-Glycoprotein PET Imaging at the Blood-Brain Barrier, file dd9e0c67-2a6f-1e9c-e053-3a05fe0a45ef
|
2
|
|
Synthesis of Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Using Deep Eutectic Solvents, file dd9e0c68-8f59-1e9c-e053-3a05fe0a45ef
|
2
|
|
Pharmacokinetic Modeling of ( R)-[ 11 C]verapamil to measure the P-Glycoprotein function in nonhuman primates, file dd9e0c6a-572a-1e9c-e053-3a05fe0a45ef
|
2
|
|
In Vivo Induction of P‑Glycoprotein Function can be Measured with [18F]MC225 and PET, file dd9e0c6b-3e42-1e9c-e053-3a05fe0a45ef
|
2
|
|
A scalable route to quaternary ammonium-functionalized AgCl colloidal antimicrobials inhibiting food pathogenic bacteria and biofilms, file df74d55e-4fbc-4376-a207-28e03fd89003
|
2
|
|
Dose-response assessment of cerebral P-glycoprotein inhibition in vivo with
[18F]MC225 and PET, file 38aef328-17b5-41c8-bf3f-988228c207a7
|
1
|
|
Liquid Biopsy beyond Cancer: A miRNA Detection in Serum with Electrochemical Chip for Non‐Invasive Coeliac Disease Diagnosis, file 7f32db53-33eb-4e7e-9fc7-1a0f321f5ae2
|
1
|
|
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity, file dd9e0c63-01d6-1e9c-e053-3a05fe0a45ef
|
1
|
|
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders, file dd9e0c63-3b70-1e9c-e053-3a05fe0a45ef
|
1
|
|
null, file dd9e0c63-b973-1e9c-e053-3a05fe0a45ef
|
1
|
|
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes, file dd9e0c63-b9ae-1e9c-e053-3a05fe0a45ef
|
1
|
|
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters, file dd9e0c63-bb1c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors, file dd9e0c63-cba2-1e9c-e053-3a05fe0a45ef
|
1
|
|
Methods and probes for determining the concentration of copper, file dd9e0c63-f4c1-1e9c-e053-3a05fe0a45ef
|
1
|
|
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity, file dd9e0c64-45ef-1e9c-e053-3a05fe0a45ef
|
1
|
|
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation, file dd9e0c64-ba42-1e9c-e053-3a05fe0a45ef
|
1
|
|
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease, file dd9e0c64-f386-1e9c-e053-3a05fe0a45ef
|
1
|
|
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments, file dd9e0c64-f389-1e9c-e053-3a05fe0a45ef
|
1
|
|
null, file dd9e0c64-f85c-1e9c-e053-3a05fe0a45ef
|
1
|
|
miRNAs for the Detection of MultiDrug Resistance: Overview
and Perspectives, file dd9e0c64-fa24-1e9c-e053-3a05fe0a45ef
|
1
|
|
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo., file dd9e0c64-fce3-1e9c-e053-3a05fe0a45ef
|
1
|
|
Radiopharmaceuticals for assessing ABC transporters at the blood-brain barrier, file dd9e0c65-4544-1e9c-e053-3a05fe0a45ef
|
1
|
|
Is the sigma-2 receptor a histone binding protein?, file dd9e0c65-ed40-1e9c-e053-3a05fe0a45ef
|
1
|
|
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers, file dd9e0c66-6c8c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers., file dd9e0c66-d386-1e9c-e053-3a05fe0a45ef
|
1
|
|
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands, file dd9e0c66-e384-1e9c-e053-3a05fe0a45ef
|
1
|
|
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies, file dd9e0c67-19ff-1e9c-e053-3a05fe0a45ef
|
1
|
|
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2., file dd9e0c67-200a-1e9c-e053-3a05fe0a45ef
|
1
|
|
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis, file dd9e0c67-273e-1e9c-e053-3a05fe0a45ef
|
1
|
|
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression, file dd9e0c67-385f-1e9c-e053-3a05fe0a45ef
|
1
|
|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e4-1e9c-e053-3a05fe0a45ef
|
1
|
|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e5-1e9c-e053-3a05fe0a45ef
|
1
|
|
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance, file dd9e0c67-813d-1e9c-e053-3a05fe0a45ef
|
1
|
|
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness, file dd9e0c68-f078-1e9c-e053-3a05fe0a45ef
|
1
|
|
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps, file dd9e0c6a-5eaa-1e9c-e053-3a05fe0a45ef
|
1
|
|
Small and innovative molecules as new strategy to revert MDR, file dd9e0c6a-86e4-1e9c-e053-3a05fe0a45ef
|
1
|
|
A novel cell-based assay to screen compounds which disrupts PrPC-Aβ1-42 oligomers
interaction, file e3364142-aedc-4345-9f4f-1fcd6b549d4d
|
1
|
|
First clinical assessment of [18F]MC225, a novel fluorine-18 labelled PET tracer for measuring functional P-glycoprotein at the blood-brain barrier, file fab55984-8d5b-4daf-8a2a-02fbdc818447
|
1
|
| Totale |
1.597 |