IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 5.407
EU - Europa 1.561
AS - Asia 637
SA - Sud America 9
OC - Oceania 8
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.628
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Nazione #
US - Stati Uniti d'America 5.394
CN - Cina 493
IT - Italia 479
SE - Svezia 424
DE - Germania 200
UA - Ucraina 112
GB - Regno Unito 96
FI - Finlandia 83
SG - Singapore 49
FR - Francia 39
BE - Belgio 31
RU - Federazione Russa 31
ES - Italia 20
IE - Irlanda 19
IN - India 18
ID - Indonesia 17
IR - Iran 12
CA - Canada 11
VN - Vietnam 11
JP - Giappone 10
AU - Australia 8
KR - Corea 7
CL - Cile 6
HK - Hong Kong 5
TR - Turchia 5
PL - Polonia 4
AT - Austria 3
CH - Svizzera 3
CZ - Repubblica Ceca 3
EE - Estonia 3
OM - Oman 3
EG - Egitto 2
MX - Messico 2
NL - Olanda 2
PT - Portogallo 2
RO - Romania 2
ZA - Sudafrica 2
AM - Armenia 1
AR - Argentina 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BR - Brasile 1
DK - Danimarca 1
DZ - Algeria 1
EC - Ecuador 1
EU - Europa 1
IM - Isola di Man 1
IS - Islanda 1
LI - Liechtenstein 1
MY - Malesia 1
PH - Filippine 1
PK - Pakistan 1
SA - Arabia Saudita 1
TH - Thailandia 1
Totale 7.628
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Città #
Fairfield 743
Chandler 613
Woodbridge 452
Houston 378
Nyköping 372
Ashburn 355
Cambridge 299
Seattle 283
Ann Arbor 278
Jacksonville 270
Wilmington 253
Bari 197
Lawrence 124
Roxbury 117
Beijing 102
Dearborn 101
Nanjing 88
New York 86
Des Moines 72
Inglewood 70
Princeton 65
Taranto 54
Boardman 42
San Diego 36
Brussels 30
Nanchang 28
Hebei 26
Jiaxing 25
Singapore 24
Shenyang 23
Brooklyn 18
Dublin 17
Guangzhou 17
London 16
Adelfia 15
Redwood City 15
Los Angeles 14
Monmouth Junction 14
Paris 14
Helsinki 13
San Mateo 13
Hefei 12
Changsha 11
Norwalk 11
Dong Ket 10
Oviedo 10
Sannicandro di Bari 10
Wuhan 10
Göttingen 9
Jinan 9
Milan 9
Tianjin 9
Bitonto 8
San Francisco 8
Toronto 8
Ardabil 7
Foshan 7
Francavilla Fontana 7
Shanghai 7
Tokyo 7
Washington 7
Chicago 6
Madrid 6
Pune 6
Augusta 5
Chiswick 5
Jena 5
Jinhua 5
Redmond 5
Harbin 4
Indiana 4
Kilburn 4
Nagold 4
Rome 4
Ahmedabad 3
Barletta 3
Brisbane 3
Brno 3
Cassino 3
Chengdu 3
Falls Church 3
Frankfurt am Main 3
Gravina In Puglia 3
Kunming 3
Langreo 3
Leawood 3
Messina 3
Mumbai 3
Muscat 3
Napoli 3
Tallinn 3
Tappahannock 3
Wuxi 3
Acton 2
Arzano 2
Auburn Hills 2
Buk-gu 2
Central 2
Chongqing 2
Coimbra 2
Totale 6.082
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Nome #
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 162
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 145
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 135
COX-1 Inhibitors: Beyond Structure Toward Therapy 130
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 126
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 125
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 119
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 118
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 117
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 116
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 114
2-(tert-Butyl)-4-phenyloxetane 112
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 111
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 109
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 109
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 107
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 105
Update on SAR studies toward new COX-1 selective inhibitors 102
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 101
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 98
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 97
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 96
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 95
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 94
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 94
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 93
Current and emerging applications of fluorine in medicinal chemistry 92
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 91
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 88
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 87
Selective COX-1 inhibition: a therapeutic target to be reconsidered 86
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 86
Reaction of 3-phenylisoxazole with alkyllithiums 86
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 86
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 86
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 86
Oxygen-Stabilized Carbanions 83
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 82
null 81
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 80
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 77
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 77
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 76
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 72
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 72
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 71
Five-member-ring heterocycles by reacting enolates with dipoles 69
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 69
Deep eutectic solvents and their applications as green solvents 69
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 68
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 67
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 66
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 65
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 63
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 63
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 62
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 61
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 60
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 59
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 58
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 57
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 57
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 56
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 56
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 55
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 55
Aspetti sintetici e meccanicistici della reazione di apertura di 3-aril-5-feniltio-2-isossazoline indotta da alchillitio 54
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 54
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 52
Diarilisossazoli funzionalizzati inibitori della ciclossigenasi 51
Regioselective synthesis and elaboration of 3-aryl-5-alkylisoxazoles 50
Use of isoxazole derivatives as cyclooxygenase inhibitors 49
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 49
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 49
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 49
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 48
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 46
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 45
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 44
Reaction of 3-phenylisoxazole with hindered lithium amides 43
REAZIONE DI ALOGENOBENZONITRILI CON LDA: UN CASO DI MECCANISMO BENZINICO DOVUTO ALL’INGOMBRO STERICO DEL NUCLEOFILO 43
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 43
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 42
Regioselective synthesis and side-chain metalation and elaboration of 3-aryl-5-alkylisoxazoles 41
Synthesis of 3-aryl-5-vinylisoxazoles: a preliminary investigation 41
Indagini sull’elaborazione in catena laterale di 3-aril-5-idrossi-5-vinil-2-isossazoline e 3-arilisossazoli 41
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 41
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 41
Selective inhibition of cyclooxygenase (COX) isoenzymes and neuroinflammation 38
Isoxazole derivatives and their use as cyclooxigenase inhibitors 38
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 38
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 38
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 37
Reduction of Epoxides 37
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 37
Metal-catalyzed and Metal-mediated Organic Reactions in Deep Eutectic Solvents and in Water 37
Isoxazole SAR for COX-1 Selective Inhibitors Development 36
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 36
2-Diphenylphosphinomethyl-3-methylpyrazine 35
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 35
Totale 7.268
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Categoria #
all - tutte 36.717
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.717
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.533 0 95 50 145 182 178 201 145 197 134 163 43
2020/20211.417 202 62 131 105 97 77 163 55 126 175 161 63
2021/2022984 60 145 24 23 53 50 38 45 67 49 149 281
2022/20231.661 215 223 130 123 191 212 14 205 217 22 46 63
2023/2024709 99 106 45 44 40 134 34 43 55 31 23 55
2024/2025148 133 15 0 0 0 0 0 0 0 0 0 0
Totale 8.143