IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 5.392
EU - Europa 1.531
AS - Asia 477
SA - Sud America 9
OC - Oceania 8
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 7.423
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Nazione #
US - Stati Uniti d'America 5.379
IT - Italia 461
SE - Svezia 425
CN - Cina 384
DE - Germania 197
UA - Ucraina 112
GB - Regno Unito 95
FI - Finlandia 82
FR - Francia 39
BE - Belgio 31
RU - Federazione Russa 29
IE - Irlanda 20
ES - Italia 18
ID - Indonesia 17
IN - India 13
IR - Iran 12
CA - Canada 11
VN - Vietnam 11
JP - Giappone 9
AU - Australia 8
KR - Corea 7
CL - Cile 6
HK - Hong Kong 5
TR - Turchia 5
PL - Polonia 4
SG - Singapore 4
AT - Austria 3
EE - Estonia 3
OM - Oman 3
EG - Egitto 2
MX - Messico 2
NL - Olanda 2
PT - Portogallo 2
RO - Romania 2
ZA - Sudafrica 2
AM - Armenia 1
AR - Argentina 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BR - Brasile 1
CH - Svizzera 1
DK - Danimarca 1
DZ - Algeria 1
EC - Ecuador 1
EU - Europa 1
IM - Isola di Man 1
IS - Islanda 1
LI - Liechtenstein 1
MY - Malesia 1
PH - Filippine 1
PK - Pakistan 1
SA - Arabia Saudita 1
TH - Thailandia 1
Totale 7.423
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Città #
Fairfield 743
Chandler 618
Woodbridge 452
Houston 378
Nyköping 373
Ashburn 353
Cambridge 299
Seattle 283
Ann Arbor 278
Jacksonville 270
Wilmington 253
Bari 194
Lawrence 124
Roxbury 117
Dearborn 101
Beijing 98
Nanjing 88
New York 86
Des Moines 73
Inglewood 70
Princeton 65
Taranto 54
San Diego 36
Boardman 31
Brussels 30
Nanchang 28
Hebei 26
Shenyang 23
Jiaxing 21
Brooklyn 18
Dublin 18
London 16
Adelfia 15
Redwood City 15
Monmouth Junction 14
Paris 14
San Mateo 13
Hefei 12
Helsinki 12
Changsha 11
Norwalk 11
Dong Ket 10
Oviedo 10
Sannicandro di Bari 10
Göttingen 9
Tianjin 9
Bitonto 8
Los Angeles 8
San Francisco 8
Toronto 8
Ardabil 7
Foshan 7
Francavilla Fontana 7
Jinan 7
Milan 7
Washington 7
Chicago 6
Pune 6
Tokyo 6
Augusta 5
Chiswick 5
Jena 5
Redmond 5
Guangzhou 4
Harbin 4
Indiana 4
Kilburn 4
Madrid 4
Nagold 4
Barletta 3
Brisbane 3
Cassino 3
Falls Church 3
Frankfurt am Main 3
Gravina In Puglia 3
Kunming 3
Langreo 3
Leawood 3
Messina 3
Mumbai 3
Muscat 3
Napoli 3
Tallinn 3
Tappahannock 3
Acton 2
Arzano 2
Auburn Hills 2
Buk-gu 2
Central 2
Chengdu 2
Chongqing 2
Coimbra 2
Cologno Monzese 2
Garching 2
Gaziantep 2
Gold Coast 2
Howick 2
La Canada Flintridge 2
Lanzhou 2
Leicester 2
Totale 5.995
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Nome #
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 159
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 144
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 134
COX-1 Inhibitors: Beyond Structure Toward Therapy 129
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 124
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 122
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 119
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 117
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 116
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 114
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 113
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 111
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 109
2-(tert-Butyl)-4-phenyloxetane 109
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 107
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 106
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 103
Update on SAR studies toward new COX-1 selective inhibitors 101
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 99
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 97
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 95
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 95
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 95
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 93
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 93
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 93
Current and emerging applications of fluorine in medicinal chemistry 92
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 90
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 86
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 86
Selective COX-1 inhibition: a therapeutic target to be reconsidered 85
Reaction of 3-phenylisoxazole with alkyllithiums 85
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 85
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 84
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 84
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 83
Oxygen-Stabilized Carbanions 82
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 81
null 81
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 77
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 76
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 76
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 76
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 70
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 69
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 68
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 68
Deep eutectic solvents and their applications as green solvents 68
Five-member-ring heterocycles by reacting enolates with dipoles 65
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 65
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 64
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 63
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 63
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 62
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 61
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 60
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 59
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 59
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 58
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 58
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 55
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 55
Aspetti sintetici e meccanicistici della reazione di apertura di 3-aril-5-feniltio-2-isossazoline indotta da alchillitio 54
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 53
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 53
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 53
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 53
Regioselective synthesis and elaboration of 3-aryl-5-alkylisoxazoles 50
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 50
Diarilisossazoli funzionalizzati inibitori della ciclossigenasi 49
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 49
Use of isoxazole derivatives as cyclooxygenase inhibitors 48
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 48
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 48
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 47
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 45
REAZIONE DI ALOGENOBENZONITRILI CON LDA: UN CASO DI MECCANISMO BENZINICO DOVUTO ALL’INGOMBRO STERICO DEL NUCLEOFILO 43
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 43
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 42
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 42
Regioselective synthesis and side-chain metalation and elaboration of 3-aryl-5-alkylisoxazoles 41
Synthesis of 3-aryl-5-vinylisoxazoles: a preliminary investigation 41
Indagini sull’elaborazione in catena laterale di 3-aril-5-idrossi-5-vinil-2-isossazoline e 3-arilisossazoli 41
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 41
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 41
Reaction of 3-phenylisoxazole with hindered lithium amides 40
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 40
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 39
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 38
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 38
Isoxazole derivatives and their use as cyclooxigenase inhibitors 37
Selective inhibition of cyclooxygenase (COX) isoenzymes and neuroinflammation 36
Reduction of Epoxides 36
Isoxazole SAR for COX-1 Selective Inhibitors Development 36
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 36
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 35
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 34
Dimerizzazione di 3-arilisossazoli a bis-β-lattami promossa da R2N-M+: studio della dipendenza della reazione dal sostituente in arile e dalla natura di M+ 33
Metal-catalyzed and Metal-mediated Organic Reactions in Deep Eutectic Solvents and in Water 33
Enaminothioesters and alkylated enaminones from 3-aryl-5-phenylthioisoxazolines 32
Totale 7.114
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Categoria #
all - tutte 33.378
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 33.378
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019323 0 0 0 0 0 0 0 0 0 0 169 154
2019/20201.842 309 95 50 145 182 178 201 145 197 134 163 43
2020/20211.417 202 62 131 105 97 77 163 55 126 175 161 63
2021/2022985 60 145 24 23 53 50 38 45 67 49 150 281
2022/20231.670 215 223 131 124 195 213 14 205 218 22 47 63
2023/2024640 99 106 45 44 41 134 34 43 58 31 5 0
Totale 7.936