IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 5.496
EU - Europa 1.659
AS - Asia 879
SA - Sud America 17
OC - Oceania 8
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.065
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Nazione #
US - Stati Uniti d'America 5.481
IT - Italia 546
CN - Cina 502
SE - Svezia 424
SG - Singapore 269
DE - Germania 203
UA - Ucraina 112
GB - Regno Unito 105
FI - Finlandia 85
FR - Francia 46
BE - Belgio 33
RU - Federazione Russa 31
ES - Italia 22
IN - India 21
ID - Indonesia 19
IE - Irlanda 19
IR - Iran 17
CA - Canada 13
VN - Vietnam 13
JP - Giappone 10
AU - Australia 8
BR - Brasile 7
KR - Corea 7
CL - Cile 6
AT - Austria 5
HK - Hong Kong 5
NL - Olanda 5
TR - Turchia 5
PL - Polonia 4
CH - Svizzera 3
CZ - Repubblica Ceca 3
EE - Estonia 3
OM - Oman 3
AR - Argentina 2
EG - Egitto 2
MX - Messico 2
PT - Portogallo 2
RO - Romania 2
ZA - Sudafrica 2
AM - Armenia 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
DK - Danimarca 1
DZ - Algeria 1
EC - Ecuador 1
EU - Europa 1
IM - Isola di Man 1
IS - Islanda 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LT - Lituania 1
MY - Malesia 1
PH - Filippine 1
PK - Pakistan 1
SA - Arabia Saudita 1
TH - Thailandia 1
VE - Venezuela 1
Totale 8.065
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Città #
Fairfield 743
Chandler 613
Woodbridge 452
Houston 378
Nyköping 372
Ashburn 371
Cambridge 299
Seattle 283
Ann Arbor 278
Jacksonville 270
Wilmington 253
Bari 215
Singapore 195
Lawrence 124
Roxbury 117
Beijing 102
Dearborn 101
Nanjing 88
New York 86
Des Moines 72
Inglewood 70
Princeton 65
Taranto 54
Boardman 45
San Diego 36
Brussels 32
Nanchang 28
Hebei 26
Jiaxing 25
London 23
Shenyang 23
Trani 23
Santa Clara 22
Brooklyn 18
Dublin 17
Guangzhou 17
Adelfia 15
Helsinki 15
Redwood City 15
Los Angeles 14
Monmouth Junction 14
Paris 14
San Mateo 13
Hefei 12
Changsha 11
Norwalk 11
Dong Ket 10
Oviedo 10
Sannicandro di Bari 10
Wuhan 10
Bitonto 9
Göttingen 9
Jinan 9
Milan 9
Tianjin 9
Toronto 9
San Francisco 8
Shanghai 8
Ardabil 7
Foshan 7
Francavilla Fontana 7
Rouen 7
Tokyo 7
Washington 7
Casamassima 6
Chicago 6
Madrid 6
Pune 6
Augusta 5
Chiswick 5
Jena 5
Jinhua 5
Redmond 5
Rome 5
Frankfurt am Main 4
Harbin 4
Indiana 4
Kilburn 4
Nagold 4
Ahmedabad 3
Barletta 3
Brisbane 3
Brno 3
Cassino 3
Chengdu 3
Falls Church 3
Gravina In Puglia 3
Kunming 3
Langreo 3
Leawood 3
Messina 3
Mumbai 3
Munich 3
Muscat 3
Napoli 3
Tallinn 3
Tappahannock 3
Wuxi 3
Acton 2
Arzano 2
Totale 6.357
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Nome #
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 165
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 150
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 147
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 137
COX-1 Inhibitors: Beyond Structure Toward Therapy 131
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 130
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 122
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 120
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 119
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 119
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 117
2-(tert-Butyl)-4-phenyloxetane 116
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 115
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 112
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 111
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 110
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 108
Update on SAR studies toward new COX-1 selective inhibitors 102
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 102
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 98
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 98
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 97
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 96
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 96
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 96
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 95
Current and emerging applications of fluorine in medicinal chemistry 93
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 92
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 90
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 90
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 88
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 88
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 88
Selective COX-1 inhibition: a therapeutic target to be reconsidered 87
Reaction of 3-phenylisoxazole with alkyllithiums 87
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 87
Oxygen-Stabilized Carbanions 85
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 85
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 84
null 81
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 80
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 80
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 79
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 78
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 76
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 76
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 75
Five-member-ring heterocycles by reacting enolates with dipoles 73
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 73
Deep eutectic solvents and their applications as green solvents 73
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 73
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 72
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 71
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 65
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 64
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 64
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 64
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 64
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 63
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 61
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 61
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 61
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 60
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 59
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 59
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 57
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 57
Aspetti sintetici e meccanicistici della reazione di apertura di 3-aril-5-feniltio-2-isossazoline indotta da alchillitio 56
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 56
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 56
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 56
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 56
Diarilisossazoli funzionalizzati inibitori della ciclossigenasi 54
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 54
Regioselective synthesis and elaboration of 3-aryl-5-alkylisoxazoles 53
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 52
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 51
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 51
Use of isoxazole derivatives as cyclooxygenase inhibitors 50
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 49
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 48
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 47
Reaction of 3-phenylisoxazole with hindered lithium amides 45
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 45
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 45
Regioselective synthesis and side-chain metalation and elaboration of 3-aryl-5-alkylisoxazoles 44
REAZIONE DI ALOGENOBENZONITRILI CON LDA: UN CASO DI MECCANISMO BENZINICO DOVUTO ALL’INGOMBRO STERICO DEL NUCLEOFILO 44
Synthesis of 3-aryl-5-vinylisoxazoles: a preliminary investigation 43
Indagini sull’elaborazione in catena laterale di 3-aril-5-idrossi-5-vinil-2-isossazoline e 3-arilisossazoli 43
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 43
Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands 41
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 40
Selective inhibition of cyclooxygenase (COX) isoenzymes and neuroinflammation 40
Reduction of Epoxides 40
Isoxazole derivatives and their use as cyclooxigenase inhibitors 40
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 40
Isoxazole SAR for COX-1 Selective Inhibitors Development 39
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 39
2-Diphenylphosphinomethyl-3-methylpyrazine 39
Metal-catalyzed and Metal-mediated Organic Reactions in Deep Eutectic Solvents and in Water 38
Totale 7.609
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Categoria #
all - tutte 40.998
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.998
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.243 0 0 0 0 182 178 201 145 197 134 163 43
2020/20211.417 202 62 131 105 97 77 163 55 126 175 161 63
2021/2022984 60 145 24 23 53 50 38 45 67 49 149 281
2022/20231.661 215 223 130 123 191 212 14 205 217 22 46 63
2023/2024709 99 106 45 44 40 134 34 43 55 31 23 55
2024/2025631 133 29 272 85 112 0 0 0 0 0 0 0
Totale 8.626