IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 7.043
AS - Asia 3.185
EU - Europa 2.632
SA - Sud America 797
AF - Africa 149
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 3
Totale 13.817
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Nazione #
US - Stati Uniti d'America 6.921
SG - Singapore 1.306
CN - Cina 802
IT - Italia 699
BR - Brasile 693
SE - Svezia 448
HK - Hong Kong 426
RU - Federazione Russa 366
DE - Germania 325
VN - Vietnam 216
GB - Regno Unito 172
UA - Ucraina 122
FI - Finlandia 117
FR - Francia 99
IN - India 95
CI - Costa d'Avorio 81
ID - Indonesia 79
CA - Canada 65
ES - Italia 45
AR - Argentina 43
AT - Austria 42
BE - Belgio 42
JP - Giappone 41
PL - Polonia 41
MX - Messico 39
NL - Olanda 39
BD - Bangladesh 37
ZA - Sudafrica 30
IE - Irlanda 27
IQ - Iraq 23
TR - Turchia 23
IR - Iran 22
PK - Pakistan 16
EC - Ecuador 15
UZ - Uzbekistan 15
CO - Colombia 10
KR - Corea 10
VE - Venezuela 10
AE - Emirati Arabi Uniti 9
CL - Cile 9
MA - Marocco 9
PY - Paraguay 9
AU - Australia 8
LT - Lituania 8
SA - Arabia Saudita 8
EG - Egitto 7
IL - Israele 7
NP - Nepal 7
PH - Filippine 7
TN - Tunisia 6
MY - Malesia 5
OM - Oman 5
PT - Portogallo 5
TW - Taiwan 5
AL - Albania 4
CZ - Repubblica Ceca 4
KE - Kenya 4
RO - Romania 4
CH - Svizzera 3
DZ - Algeria 3
EE - Estonia 3
HN - Honduras 3
JO - Giordania 3
PA - Panama 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AZ - Azerbaigian 2
BG - Bulgaria 2
BO - Bolivia 2
GA - Gabon 2
JM - Giamaica 2
MD - Moldavia 2
NO - Norvegia 2
PE - Perù 2
PS - Palestinian Territory 2
RS - Serbia 2
SV - El Salvador 2
TH - Thailandia 2
XK - ???statistics.table.value.countryCode.XK??? 2
AM - Armenia 1
AO - Angola 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BS - Bahamas 1
BW - Botswana 1
CD - Congo 1
CV - Capo Verde 1
CY - Cipro 1
DK - Danimarca 1
DM - Dominica 1
DO - Repubblica Dominicana 1
EU - Europa 1
GD - Grenada 1
GI - Gibilterra 1
GR - Grecia 1
GT - Guatemala 1
HR - Croazia 1
HU - Ungheria 1
IM - Isola di Man 1
IS - Islanda 1
Totale 13.803
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Città #
Ashburn 767
Fairfield 743
Singapore 652
Chandler 613
Woodbridge 452
Hong Kong 417
Houston 387
Nyköping 372
Cambridge 299
Bari 292
Seattle 292
Ann Arbor 278
Jacksonville 273
Beijing 261
Wilmington 256
Dallas 192
New York 134
Lawrence 124
Roxbury 117
Dearborn 101
Los Angeles 92
Nanjing 88
Abidjan 80
Ho Chi Minh City 78
Des Moines 72
São Paulo 72
Inglewood 71
Princeton 65
Munich 59
Taranto 54
Hanoi 52
Jakarta 48
Boardman 46
Santa Clara 44
Nuremberg 38
London 37
San Diego 36
Tokyo 36
Brussels 35
Council Bluffs 35
Brooklyn 34
Chicago 32
Helsinki 31
Buffalo 30
Nanchang 28
Warsaw 28
Hebei 26
Stockholm 26
Dublin 25
Jiaxing 25
Rio de Janeiro 24
San Jose 24
Shenyang 23
Trani 23
Guangzhou 21
Johannesburg 21
Moscow 21
The Dalles 21
Montreal 20
Paris 20
Columbus 19
Milan 19
San Francisco 19
Toronto 19
Frankfurt am Main 18
Amsterdam 17
Denver 16
Mexico City 16
Oviedo 16
Turku 16
Adelfia 15
Boston 15
Redwood City 15
Vienna 15
Monmouth Junction 14
Tashkent 14
Atlanta 13
Hefei 13
Manchester 13
Mumbai 13
Poplar 13
San Mateo 13
Shanghai 13
Changsha 12
Da Nang 12
Norwalk 12
Phoenix 12
Chennai 11
Dhaka 11
Orem 11
Baghdad 10
Belo Horizonte 10
Curitiba 10
Dong Ket 10
Jinan 10
Querétaro 10
Sannicandro di Bari 10
Tianjin 10
Wuhan 10
Ahmedabad 9
Totale 9.197
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Nome #
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 215
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 211
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 207
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 195
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 180
2-(tert-Butyl)-4-phenyloxetane 176
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 167
COX-1 Inhibitors: Beyond Structure Toward Therapy 164
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 163
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 162
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 161
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 160
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 157
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 154
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 152
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 147
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 144
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 140
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 140
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 140
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 135
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 134
Current and emerging applications of fluorine in medicinal chemistry 134
Update on SAR studies toward new COX-1 selective inhibitors 133
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 132
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 131
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 130
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 130
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 125
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 125
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 123
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 122
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 122
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 122
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 121
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 120
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 120
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 119
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 118
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 117
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 116
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 115
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 115
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 114
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 113
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 111
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 111
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 111
Oxygen-Stabilized Carbanions 110
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 110
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 109
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 109
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 108
Reaction of 3-phenylisoxazole with alkyllithiums 108
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 108
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 107
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 107
Deep eutectic solvents and their applications as green solvents 106
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 105
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 104
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 104
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 104
Selective COX-1 inhibition: a therapeutic target to be reconsidered 103
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 102
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 102
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 102
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 99
2-Diphenylphosphinomethyl-3-methylpyrazine 99
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 98
Five-member-ring heterocycles by reacting enolates with dipoles 95
Reduction of Epoxides 94
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 93
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 93
Metal-mediated and Metal-catalysed Reactions in Nonconventional Solvents: Mechanistic and Synthetic Aspects 93
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 92
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 91
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 90
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 88
Deep Eutectic Solvent And Water As Two Environmentally Benign And Recyclable Reaction Media For Efficient Goldberg–Type C–N Coupling Reactions. 86
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 85
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 85
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 84
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 81
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Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 81
A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature 80
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 79
A multicomponent palladium-catalyzed carbonylative approach to imidazopyridinyl-N,N-dialkylacetamides 79
Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands 79
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 78
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 77
Direct Palladium-Catalysed Cross-Coupling Reactions Between Organolithium or Organozinc Reagents and (Hetero)Aryl Bromides in Nonconventional Solvents 77
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 76
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 75
Aspetti sintetici e meccanicistici della reazione di apertura di 3-aril-5-feniltio-2-isossazoline indotta da alchillitio 74
Metal-catalyzed and Metal-mediated Organic Reactions in Deep Eutectic Solvents and in Water 74
Introducing Water and Deep Eutectic Solvents in Organosodium Chemistry: Chemoselective Nucleophilic Functionalizations in Air 73
Synthesis and Photochemical Characterization of Indolizine Fluorophores Obtained by a Multicomponent Palladium Iodide‒Catalyzed Oxidative Aminocarbonylation Approach 73
Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry 72
Michael Additions of Organozincates to Nitrostyrenes and Coumarins for the Obtainment of New Chelating Agents Potentially Useful in Alzheimer’s Disease Treatment 72
Totale 11.508
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Categoria #
all - tutte 64.083
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 64.083
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021820 0 0 0 0 0 77 163 55 126 175 161 63
2021/2022984 60 145 24 23 53 50 38 45 67 49 149 281
2022/20231.661 215 223 130 123 191 212 14 205 217 22 46 63
2023/2024709 99 106 45 44 40 134 34 43 55 31 23 55
2024/20253.098 133 29 272 85 142 270 368 319 111 144 409 816
2025/20263.371 885 320 520 627 763 256 0 0 0 0 0 0
Totale 14.464