IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 8.295
AS - Asia 3.938
EU - Europa 3.622
SA - Sud America 965
AF - Africa 215
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 3
Totale 17.049
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Nazione #
US - Stati Uniti d'America 8.064
SG - Singapore 1.506
IT - Italia 1.390
CN - Cina 932
BR - Brasile 765
HK - Hong Kong 479
SE - Svezia 449
RU - Federazione Russa 374
DE - Germania 367
VN - Vietnam 260
FR - Francia 231
GB - Regno Unito 199
IN - India 170
FI - Finlandia 152
UA - Ucraina 124
CA - Canada 121
BD - Bangladesh 101
ID - Indonesia 93
CI - Costa d'Avorio 83
AR - Argentina 70
MX - Messico 65
ES - Italia 59
PL - Polonia 49
TR - Turchia 47
ZA - Sudafrica 47
IQ - Iraq 46
JP - Giappone 46
NL - Olanda 46
BE - Belgio 45
AT - Austria 42
PK - Pakistan 40
CO - Colombia 31
IE - Irlanda 31
EC - Ecuador 30
PH - Filippine 24
UZ - Uzbekistan 24
KR - Corea 23
IR - Iran 22
MA - Marocco 22
VE - Venezuela 22
MY - Malesia 18
SA - Arabia Saudita 15
TN - Tunisia 14
AE - Emirati Arabi Uniti 13
CL - Cile 13
PY - Paraguay 13
EG - Egitto 11
AU - Australia 10
KE - Kenya 10
AZ - Azerbaigian 9
IL - Israele 9
JM - Giamaica 9
LT - Lituania 9
NP - Nepal 9
BO - Bolivia 8
DZ - Algeria 8
JO - Giordania 8
PT - Portogallo 8
OM - Oman 7
PE - Perù 6
TT - Trinidad e Tobago 6
TW - Taiwan 6
UY - Uruguay 6
HN - Honduras 5
KZ - Kazakistan 5
AL - Albania 4
BG - Bulgaria 4
CZ - Repubblica Ceca 4
ET - Etiopia 4
NO - Norvegia 4
PA - Panama 4
PS - Palestinian Territory 4
RO - Romania 4
RS - Serbia 4
CH - Svizzera 3
CR - Costa Rica 3
EE - Estonia 3
GR - Grecia 3
GT - Guatemala 3
TH - Thailandia 3
BS - Bahamas 2
CY - Cipro 2
DO - Repubblica Dominicana 2
GA - Gabon 2
GD - Grenada 2
HU - Ungheria 2
KG - Kirghizistan 2
LB - Libano 2
MD - Moldavia 2
NI - Nicaragua 2
PR - Porto Rico 2
QA - Qatar 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
SV - El Salvador 2
TJ - Tagikistan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
Totale 17.017
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Città #
Ashburn 929
Singapore 788
Fairfield 743
Chandler 613
San Jose 496
Hong Kong 467
Woodbridge 452
Houston 392
Nyköping 372
Milan 317
Bari 307
Cambridge 299
Seattle 292
Beijing 282
Ann Arbor 278
Jacksonville 276
Wilmington 256
Dallas 200
New York 151
Lawrence 124
Lauterbourg 117
Roxbury 117
Rome 110
Los Angeles 105
Dearborn 102
Ho Chi Minh City 91
Nanjing 88
Abidjan 82
Santa Clara 78
Council Bluffs 77
São Paulo 77
Des Moines 72
Inglewood 71
Helsinki 65
Princeton 65
Boardman 61
Munich 59
Taranto 58
Hanoi 57
Jakarta 51
Columbus 49
Tokyo 41
London 40
Chicago 39
Nuremberg 39
Atlanta 37
Brooklyn 36
Brussels 36
San Diego 36
Buffalo 34
Frankfurt am Main 33
Figino 32
Warsaw 31
Vancouver 30
Dublin 29
Johannesburg 29
Nanchang 29
Mexico City 28
Stockholm 27
Hebei 26
Rio de Janeiro 26
Jiaxing 25
Oviedo 25
Falkenstein 24
Montreal 24
Shenyang 24
Toronto 24
Turin 24
Guangzhou 23
Tashkent 23
Trani 23
Orem 22
Paris 22
Denver 21
Moscow 21
San Francisco 21
The Dalles 21
Baghdad 20
Amsterdam 19
Mumbai 19
Basingstoke 17
Chennai 17
Dhaka 16
Manchester 16
Turku 16
Adelfia 15
Boston 15
Phoenix 15
Redwood City 15
Vienna 15
Istanbul 14
Monmouth Junction 14
Seoul 14
Shanghai 14
Da Nang 13
Hefei 13
Naples 13
Poplar 13
Pune 13
Quito 13
Totale 11.060
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 253
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 241
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 233
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 216
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 203
2-(tert-Butyl)-4-phenyloxetane 196
COX-1 Inhibitors: Beyond Structure Toward Therapy 193
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 191
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 189
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 188
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 185
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 185
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 184
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 184
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 179
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 175
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 173
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 165
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 165
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 157
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 156
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 154
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 154
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 153
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 153
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 153
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 151
Current and emerging applications of fluorine in medicinal chemistry 150
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 149
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 148
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 145
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 144
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 143
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 143
Update on SAR studies toward new COX-1 selective inhibitors 142
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 142
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 142
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 140
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 138
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 138
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 137
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 136
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 135
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 135
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 135
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 134
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 132
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 132
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 131
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 131
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 130
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 130
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 129
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 128
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 127
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 126
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 125
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 125
Deep eutectic solvents and their applications as green solvents 125
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 124
Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands 124
Reaction of 3-phenylisoxazole with alkyllithiums 123
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 123
Oxygen-Stabilized Carbanions 122
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 122
2-Diphenylphosphinomethyl-3-methylpyrazine 121
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 120
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 119
Selective COX-1 inhibition: a therapeutic target to be reconsidered 116
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 115
Metal-mediated and Metal-catalysed Reactions in Nonconventional Solvents: Mechanistic and Synthetic Aspects 114
Deep Eutectic Solvent And Water As Two Environmentally Benign And Recyclable Reaction Media For Efficient Goldberg–Type C–N Coupling Reactions. 112
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 111
A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature 111
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 110
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 109
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 109
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 108
Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry 107
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 107
Direct Palladium-Catalysed Cross-Coupling Reactions Between Organolithium or Organozinc Reagents and (Hetero)Aryl Bromides in Nonconventional Solvents 107
Five-member-ring heterocycles by reacting enolates with dipoles 104
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 103
Reduction of Epoxides 102
Synthesis and Photochemical Characterization of Indolizine Fluorophores Obtained by a Multicomponent Palladium Iodide‒Catalyzed Oxidative Aminocarbonylation Approach 100
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 100
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 98
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 98
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 96
Deep Eutectic Solvents as Non-innocent and Environmentally Responsible Reaction Media for the Divergent Synthesis of Valuable N-Heterocycles from Azides 96
A multicomponent palladium-catalyzed carbonylative approach to imidazopyridinyl-N,N-dialkylacetamides 95
A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles 95
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 94
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 93
Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach 92
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 92
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 92
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 91
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 91
A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions 90
Totale 13.632
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Categoria #
all - tutte 73.286
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 73.286
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022984 60 145 24 23 53 50 38 45 67 49 149 281
2022/20231.661 215 223 130 123 191 212 14 205 217 22 46 63
2023/2024709 99 106 45 44 40 134 34 43 55 31 23 55
2024/20253.098 133 29 272 85 142 270 368 319 111 144 409 816
2025/20266.455 885 320 520 627 763 304 659 237 613 621 280 626
2026/2027196 196 0 0 0 0 0 0 0 0 0 0 0
Totale 17.744