IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 8.032
AS - Asia 3.863
EU - Europa 3.060
SA - Sud America 954
AF - Africa 214
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 3
Totale 16.137
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Nazione #
US - Stati Uniti d'America 7.852
SG - Singapore 1.488
CN - Cina 923
IT - Italia 849
BR - Brasile 757
HK - Hong Kong 469
SE - Svezia 443
RU - Federazione Russa 371
DE - Germania 367
VN - Vietnam 258
FR - Francia 230
GB - Regno Unito 198
IN - India 168
FI - Finlandia 152
UA - Ucraina 124
ID - Indonesia 93
CA - Canada 87
CI - Costa d'Avorio 82
BD - Bangladesh 72
AR - Argentina 69
MX - Messico 63
ES - Italia 59
PL - Polonia 47
TR - Turchia 47
ZA - Sudafrica 47
IQ - Iraq 46
NL - Olanda 45
JP - Giappone 44
AT - Austria 42
BE - Belgio 42
PK - Pakistan 39
CO - Colombia 30
EC - Ecuador 30
IE - Irlanda 30
PH - Filippine 24
UZ - Uzbekistan 24
KR - Corea 23
IR - Iran 22
MA - Marocco 22
VE - Venezuela 22
MY - Malesia 18
SA - Arabia Saudita 15
TN - Tunisia 14
CL - Cile 13
PY - Paraguay 13
AE - Emirati Arabi Uniti 12
EG - Egitto 11
AU - Australia 10
KE - Kenya 10
AZ - Azerbaigian 9
IL - Israele 9
LT - Lituania 9
NP - Nepal 9
BO - Bolivia 8
DZ - Algeria 8
JO - Giordania 7
OM - Oman 7
JM - Giamaica 6
PE - Perù 6
TW - Taiwan 6
KZ - Kazakistan 5
PT - Portogallo 5
UY - Uruguay 5
AL - Albania 4
BG - Bulgaria 4
CZ - Repubblica Ceca 4
ET - Etiopia 4
HN - Honduras 4
NO - Norvegia 4
PA - Panama 4
PS - Palestinian Territory 4
RO - Romania 4
RS - Serbia 4
TT - Trinidad e Tobago 4
CH - Svizzera 3
EE - Estonia 3
GR - Grecia 3
TH - Thailandia 3
CY - Cipro 2
DO - Repubblica Dominicana 2
GA - Gabon 2
GD - Grenada 2
HU - Ungheria 2
KG - Kirghizistan 2
LB - Libano 2
MD - Moldavia 2
NI - Nicaragua 2
QA - Qatar 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
SV - El Salvador 2
TJ - Tagikistan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BJ - Benin 1
BN - Brunei Darussalam 1
BS - Bahamas 1
Totale 16.108
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Città #
Ashburn 896
Singapore 778
Fairfield 736
Chandler 606
San Jose 486
Hong Kong 457
Woodbridge 450
Houston 391
Nyköping 368
Bari 302
Cambridge 297
Seattle 290
Beijing 279
Jacksonville 276
Ann Arbor 274
Wilmington 252
Dallas 196
New York 148
Lawrence 123
Lauterbourg 117
Roxbury 116
Dearborn 102
Los Angeles 102
Ho Chi Minh City 90
Nanjing 88
Abidjan 81
Council Bluffs 77
São Paulo 75
Des Moines 72
Inglewood 70
Helsinki 65
Princeton 65
Santa Clara 65
Boardman 61
Munich 59
Hanoi 57
Taranto 56
Jakarta 51
London 40
Nuremberg 39
Tokyo 39
Atlanta 37
Brooklyn 35
San Diego 34
Brussels 33
Frankfurt am Main 33
Buffalo 32
Chicago 32
Milan 32
Warsaw 31
Johannesburg 29
Nanchang 29
Dublin 28
Mexico City 27
Hebei 26
Rio de Janeiro 26
Jiaxing 25
Oviedo 25
Stockholm 25
Falkenstein 24
Shenyang 24
Guangzhou 23
Montreal 23
Tashkent 23
Orem 22
Paris 22
Toronto 22
Trani 22
Columbus 21
Moscow 21
San Francisco 21
The Dalles 21
Baghdad 20
Amsterdam 19
Mumbai 19
Denver 18
Basingstoke 17
Chennai 17
Rome 17
Manchester 16
Turku 16
Adelfia 15
Boston 15
Dhaka 15
Redwood City 15
Vienna 15
Istanbul 14
Monmouth Junction 14
Seoul 14
Shanghai 14
Da Nang 13
Hefei 13
Phoenix 13
Poplar 13
Pune 13
Quito 13
Belo Horizonte 12
Changsha 12
Lahore 12
Medellín 12
Totale 10.436
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 241
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 234
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 227
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 208
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 195
2-(tert-Butyl)-4-phenyloxetane 188
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 185
COX-1 Inhibitors: Beyond Structure Toward Therapy 183
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 183
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 182
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 179
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 179
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 178
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 177
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 170
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 167
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 159
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 157
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 157
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 157
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 153
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 151
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 150
Current and emerging applications of fluorine in medicinal chemistry 148
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 147
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 146
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 145
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 143
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 142
Update on SAR studies toward new COX-1 selective inhibitors 141
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 141
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 140
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 137
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 136
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 136
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 134
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 133
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 131
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 131
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 131
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 130
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 130
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 130
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 129
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 128
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 128
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 127
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 127
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 126
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 125
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 125
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 124
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 123
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 123
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 122
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 121
Deep eutectic solvents and their applications as green solvents 121
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 121
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 120
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 120
Reaction of 3-phenylisoxazole with alkyllithiums 118
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 118
Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands 118
Oxygen-Stabilized Carbanions 117
2-Diphenylphosphinomethyl-3-methylpyrazine 115
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 114
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 114
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 113
Deep Eutectic Solvent And Water As Two Environmentally Benign And Recyclable Reaction Media For Efficient Goldberg–Type C–N Coupling Reactions. 111
Selective COX-1 inhibition: a therapeutic target to be reconsidered 109
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 109
Metal-mediated and Metal-catalysed Reactions in Nonconventional Solvents: Mechanistic and Synthetic Aspects 107
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 105
A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature 105
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 104
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 103
Five-member-ring heterocycles by reacting enolates with dipoles 102
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 102
Reduction of Epoxides 101
Direct Palladium-Catalysed Cross-Coupling Reactions Between Organolithium or Organozinc Reagents and (Hetero)Aryl Bromides in Nonconventional Solvents 101
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 99
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 98
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 98
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 96
Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry 95
Deep Eutectic Solvents as Non-innocent and Environmentally Responsible Reaction Media for the Divergent Synthesis of Valuable N-Heterocycles from Azides 95
A multicomponent palladium-catalyzed carbonylative approach to imidazopyridinyl-N,N-dialkylacetamides 94
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 93
Synthesis and Photochemical Characterization of Indolizine Fluorophores Obtained by a Multicomponent Palladium Iodide‒Catalyzed Oxidative Aminocarbonylation Approach 92
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 90
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 90
Introducing Water and Deep Eutectic Solvents in Organosodium Chemistry: Chemoselective Nucleophilic Functionalizations in Air 87
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 87
Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach 86
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 86
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 85
Aspetti sintetici e meccanicistici della reazione di apertura di 3-aril-5-feniltio-2-isossazoline indotta da alchillitio 85
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 85
A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles 85
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 84
Totale 13.018
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Categoria #
all - tutte 69.634
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 69.634
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202160 0 0 0 0 0 0 0 0 0 0 0 60
2021/2022971 60 145 23 23 53 48 37 45 63 49 148 277
2022/20231.644 214 220 128 122 188 209 14 204 214 22 46 63
2023/2024705 99 104 45 44 40 132 34 43 55 31 23 55
2024/20253.048 130 29 269 85 142 266 363 316 111 141 387 809
2025/20265.837 881 319 518 620 753 304 658 237 607 618 280 42
Totale 16.822