IRIS
VITALE, PAOLA
 Distribuzione geografica
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Continente #
NA - Nord America 9.060
AS - Asia 3.996
EU - Europa 3.683
SA - Sud America 990
Continente sconosciuto - Info sul continente non disponibili 698
AF - Africa 222
OC - Oceania 11
Totale 18.660
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Nazione #
US - Stati Uniti d'America 8.799
SG - Singapore 1.512
IT - Italia 1.432
CN - Cina 944
BR - Brasile 773
HK - Hong Kong 484
SE - Svezia 449
RU - Federazione Russa 374
DE - Germania 370
VN - Vietnam 261
FR - Francia 231
GB - Regno Unito 210
IN - India 176
FI - Finlandia 152
CA - Canada 135
UA - Ucraina 124
BD - Bangladesh 117
ID - Indonesia 97
CI - Costa d'Avorio 83
AR - Argentina 72
MX - Messico 67
ES - Italia 60
PL - Polonia 51
JP - Giappone 47
TR - Turchia 47
ZA - Sudafrica 47
IQ - Iraq 46
NL - Olanda 46
BE - Belgio 45
AT - Austria 42
PK - Pakistan 40
CO - Colombia 38
EC - Ecuador 34
IE - Irlanda 31
VE - Venezuela 26
PH - Filippine 25
UZ - Uzbekistan 24
KR - Corea 23
IR - Iran 22
MA - Marocco 22
MY - Malesia 18
SA - Arabia Saudita 17
AE - Emirati Arabi Uniti 14
TN - Tunisia 14
CL - Cile 13
JM - Giamaica 13
PY - Paraguay 13
EG - Egitto 11
KE - Kenya 11
AU - Australia 10
LT - Lituania 10
TT - Trinidad e Tobago 10
AZ - Azerbaigian 9
IL - Israele 9
NP - Nepal 9
BO - Bolivia 8
DZ - Algeria 8
JO - Giordania 8
PT - Portogallo 8
HN - Honduras 7
KZ - Kazakistan 7
OM - Oman 7
CR - Costa Rica 6
PE - Perù 6
TW - Taiwan 6
UY - Uruguay 6
SC - Seychelles 5
AL - Albania 4
BG - Bulgaria 4
CZ - Repubblica Ceca 4
ET - Etiopia 4
NO - Norvegia 4
PA - Panama 4
PS - Palestinian Territory 4
RO - Romania 4
RS - Serbia 4
TH - Thailandia 4
CH - Svizzera 3
DO - Repubblica Dominicana 3
EE - Estonia 3
GR - Grecia 3
GT - Guatemala 3
BS - Bahamas 2
CY - Cipro 2
GA - Gabon 2
GD - Grenada 2
HR - Croazia 2
HU - Ungheria 2
KG - Kirghizistan 2
LB - Libano 2
MD - Moldavia 2
NI - Nicaragua 2
PR - Porto Rico 2
QA - Qatar 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
SV - El Salvador 2
TJ - Tagikistan 2
XK - ???statistics.table.value.countryCode.XK??? 2
AM - Armenia 1
Totale 17.931
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Città #
Ashburn 1.070
Singapore 791
Fairfield 743
San Jose 618
Chandler 613
Hong Kong 470
Woodbridge 452
Houston 393
Nyköping 372
Milan 318
Bari 309
Cambridge 300
Seattle 295
Beijing 284
Ann Arbor 278
Jacksonville 276
Wilmington 256
Council Bluffs 234
Dallas 208
New York 154
Lawrence 124
Lauterbourg 117
Roxbury 117
Los Angeles 114
Rome 114
Dearborn 102
Santa Clara 102
Ho Chi Minh City 92
Nanjing 88
Abidjan 82
São Paulo 79
Des Moines 72
Inglewood 71
Princeton 66
Helsinki 65
Boardman 63
Munich 59
Taranto 58
Hanoi 57
Columbus 51
Jakarta 51
Chicago 50
London 44
Tokyo 42
Atlanta 40
Nuremberg 39
Buffalo 38
Brooklyn 37
Brussels 36
San Diego 36
Frankfurt am Main 33
Figino 32
Warsaw 31
Vancouver 30
Dublin 29
Johannesburg 29
Nanchang 29
Mexico City 28
Stockholm 27
Hebei 26
Rio de Janeiro 26
Jiaxing 25
Oviedo 25
Toronto 25
Turin 25
Falkenstein 24
Montreal 24
San Francisco 24
Shenyang 24
Guangzhou 23
Tashkent 23
Trani 23
Denver 22
Orem 22
Paris 22
Phoenix 22
Moscow 21
The Dalles 21
Baghdad 20
Amsterdam 19
Mumbai 19
Basingstoke 17
Chennai 17
Shanghai 17
Dhaka 16
Manchester 16
Pune 16
Quito 16
Turku 16
Adelfia 15
Boston 15
Naples 15
Redwood City 15
Vienna 15
Columbia 14
Istanbul 14
Monmouth Junction 14
Seoul 14
Caracas 13
Da Nang 13
Totale 11.601
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 262
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 250
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 235
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 217
Unprecedented Nucleophilic Additions of Highly Polar Organometallic Compounds to Imines and Nitriles Using Water as a Non-Innocent Reaction Medium 204
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 201
COX-1 Inhibitors: Beyond Structure Toward Therapy 200
Water and Sodium Chloride: Essential Ingredients for Robust and Fast Pd-catalysed Cross-coupling Reactions between Organolithiums and (Hetero)aryl halides 197
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 197
2-(tert-Butyl)-4-phenyloxetane 197
Addition of Highly Polarized Organometallic Compounds to N-tert-Butanesulfinyl Imines in Deep Eutectic Solvents under Air: Preparation of Chiral Amines of Pharmaceutical Interest 192
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 188
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 188
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 187
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 182
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 175
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 175
Unveiling the Hidden Performance of Whole Cells in the Asymmetric Bioreduction of Aryl-containing Ketones in Aqueous Deep Eutectic Solvents 175
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 169
Expeditious and practical synthesis of tertiary alcohols from esters enabled by highly polarized organometallic compounds under aerobic conditions in Deep Eutectic Solvents or bulk water 169
Lactic Acid Bacteria as New Whole-Cells Biocatalysts for the Stereoselective Synthesis of Chiral Enantiopure Building Blocks 161
Conjugate Additions of Organolithiums to Electron-poor Olefins: A Simple and Useful Approach to the Synthesis of Complex Molecules 160
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 159
Sustainable Ligand-Free Heterogeneous Palladium-Catalyzed Sonogashira Cross-Coupling Reaction in Deep Eutectic Solvents 158
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 157
Solvent-catalyzed umpolung carbon-sulfur bond-forming reactions by nucleophilic addition of thiolate and sulfinate ions to in situ-derived nitrosoalkenes in deep eutectic solvents 155
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 155
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 154
Current and emerging applications of fluorine in medicinal chemistry 154
Ligand-Free Bioinspired Suzuki–Miyaura Coupling Reactions using Aryltrifluoroborates as Effective Partners in Deep Eutectic Solvents 153
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 152
1,3‐Dipolar Cycloaddition of Alkanone Enolates with Azides in Deep Eutectic Solvents for the Metal‐Free Regioselective Synthesis of Densely Functionalized 1,2,3‐Triazoles 150
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 149
Nucleophilic Addition of Thiolate and Sulfinate Ions to in Situ-derived Nitrosoalkenes in Low Transition Temperature Mixtures 149
Boosting Conjugate Addition to Nitroolefins Using Lithium Tetraorganozincates: Synthetic Strategies and Structural Insights 148
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 147
An expeditious and greener synthesis of 2-aminoimidazoles in deep eutectic solvents 147
Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents 147
Advances in Deep Eutectic Solvents and Water: Applications in Metal- and Biocatalyzed Processes, in the Synthesis of APIs, and other Biologically Active Compounds 146
Update on SAR studies toward new COX-1 selective inhibitors 145
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 144
Whole-Cell Biocatalyst for Chemoenzymatic Total Synthesis of Rivastigmine 144
Unprecedented “On-Water” Nucleophilic Addition of Organolithiums and Grignard Reagents to Imines and Nitriles 143
Chemoselective Addition of Organozinc Reagents to Carbonyl Compounds, Nitrosoalkenes and β-Nitroolefines in Deep Eutectic Solvent 142
Synthesis of Functionalised Aryl and Heteroaryl Compounds via Ligand-Free Metal-Catalysed Kumada and Ullmann Cross Coupling Reactions in Unconventional Reaction Media 141
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 140
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 139
Chiral non-racemic aryl-substituted oxetanes: stereoselective chemo-enzymatic synthesis and regioselective functionalization by metallation 139
A Chemo-Enzymatic Approach to the Synthesis of Optically Active 2,4-Disubstituted Aryloxetanes 138
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 138
Copper-catalyzed Goldberg-type C–N coupling in deep eutectic solvents (DESs) and water under aerobic conditions 136
Ultrafast Pd-catalyzed Cross-Coupling Reactions of (hetero)aryl-bromides with Organolithium Compounds Under “On-Water” Conditions 135
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 134
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions With Aryl Boronic Acids And Potassium Aryl Trifluoroborates In Deep Eutectic Solvents 134
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 133
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 133
Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents 131
Deep eutectic solvents and their applications as green solvents 130
Scalable Negishi Coupling between Organozinc Compounds and (Hetero)Aryl Bromides under Aerobic Conditions when using Bulk Water or Deep Eutectic Solvents with no Additional Ligands 130
Oxygen-Stabilized Carbanions 129
Dearomatising Coumarins via Regio-, Chemo- and Stereoselective Nucleophilic Additions of Lithium Zincate Species 128
Ligand-Free Suzuki–Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: A Novel Sustainable Approach Towards Bi- And Tri(Hetero)Aryl Compounds 128
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 127
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 126
Palladium-Catalyzed Cyclocarbonylation Approach to Thiadiazafluorenones. A Correction 126
Metal-mediated and Metal-catalysed Reactions in Nonconventional Solvents: Mechanistic and Synthetic Aspects 126
Reaction of 3-phenylisoxazole with alkyllithiums 125
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 123
Chemoselective Addition of Organozinc Reagents to Carbonylic Compounds and β-Nitroolefins in Deep Eutectic Solvents 122
2-Diphenylphosphinomethyl-3-methylpyrazine 122
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 121
Selective COX-1 inhibition: a therapeutic target to be reconsidered 119
Deep Eutectic Solvent And Water As Two Environmentally Benign And Recyclable Reaction Media For Efficient Goldberg–Type C–N Coupling Reactions. 118
Direct Palladium-Catalysed Cross-Coupling Reactions Between Organolithium or Organozinc Reagents and (Hetero)Aryl Bromides in Nonconventional Solvents 117
3-Aryl-2-isoxazolines and 3-arylisoxazoles from reaction of arylnitrile oxides and enolates: synthesis and reactivity 116
Regio- and Chemoselective Michael Addition of Lithium Zincate Species to Nitroolefins with No Additional Solvents: Synthetic and Structural Aspects 116
A one-pot two-step synthesis of tertiary alcohols combining the biocatalytic laccase/TEMPO oxidation system with organolithium reagents in aerobic aqueous media at room temperature 115
Sustainable and Scalable Two-Step Synthesis of Thenfadil and Some Analogs in Deep Eutectic Solvents: From Laboratory to Industry 113
Addizione Nucleofila di Oganolitio e Reattivi di Grignard ad Immine e Nitrili in Condizioni “On-Water” 113
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 110
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 109
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 108
Five-member-ring heterocycles by reacting enolates with dipoles 108
Synthesis of New Chelating Agents Potentially Useful as Markers for Neurodegenerative Diseases Through Cross-coupling and Metal-halogen Exchange Reactions Using Lithium or Magnesium Zincate Species in Unconventional Solvents 108
Ligand-Free Suzuki-Miyaura Cross-Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of Their Optical and Electrochemical Performance 105
Reduction of Epoxides 103
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 103
Synthesis and Photochemical Characterization of Indolizine Fluorophores Obtained by a Multicomponent Palladium Iodide‒Catalyzed Oxidative Aminocarbonylation Approach 102
Chemoselective Michael Additions of Alkali-metal Zincates to Nitrostyrenes in Deep Eutectic Solvents and Under Neat Conditions 102
Deep Eutectic Solvents as Non-innocent and Environmentally Responsible Reaction Media for the Divergent Synthesis of Valuable N-Heterocycles from Azides 100
Basic and Nucleophilic Action of Alkyllithiums in Reactions with 3-Phenylisoxazole 99
Ligand‐free Copper‐Catalyzed Ullmann‐type C–O Bond Formation in Non‐innocent Deep Eutectic Solvents under Aerobic Conditions 99
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 98
Synthesis of bi- and tri(hetero)aryl Compounds Via Suzuki-Miyaura Cross-Coupling Reaction in Deep Eutectic Solvents 98
A multicomponent palladium-catalyzed carbonylative approach to imidazopyridinyl-N,N-dialkylacetamides 98
A Zinc-Mediated Deprotective Annulation Approach to New Polycyclic Heterocycles 97
Green Solvents for Eco-Friendly Synthesis of Dimethindene: A Forward-Looking Approach 96
Regio- and stereoselective biocatalytic hydration of fatty acids from waste cooking oils en route to hydroxy fatty acids and bio-based polyesters 96
Chemoselective Addition of Lithium Phosphides to Aldehydes and Epoxides in Deep Eutectic Solvents 95
A Sustainable Synthetic Approach to Tacrine and Cholinesterase Inhibitors in Deep Eutectic Solvents under Aerobic Conditions 94
Totale 14.168
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Categoria #
all - tutte 76.826
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.826
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022779 0 0 24 23 53 50 38 45 67 49 149 281
2022/20231.661 215 223 130 123 191 212 14 205 217 22 46 63
2023/2024709 99 106 45 44 40 134 34 43 55 31 23 55
2024/20253.098 133 29 272 85 142 270 368 319 111 144 409 816
2025/20266.455 885 320 520 627 763 304 659 237 613 621 280 626
2026/20271.112 238 309 565 0 0 0 0 0 0 0 0 0
Totale 18.660