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EnglishKluyveromyces marxianus CBS 6556 growing cell versatility in the enantioselective reduction of ketone-carbonyl functionality to the corresponding alcohols was exploited. In particular, methyl ketones were reduced to (S)-alcohols with ee up to 96%. Longer chain alkyl ketones afford, in the same experimental condition, (R)-alcohols with ee up to 84%. Interestingly, carbon-carbon double and triple bond of ketones can also be reduced in the presence of Kluyveromyces marxianus CBS 6556 yeast. Endocyclic carbonyl functionality, such as 2-tetralone carbonyl, is also quantitatively reduced to its (S)-alcohol with ee = 76%.
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| Titolo: | Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction |
| Autori: | SCILIMATI, Antonio [Membro del Collaboration Group] |
| Data di pubblicazione: | 2011 |
| Rivista: | |
| Citazione: | Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction / VITALE P; PERNA F.M; PERRONE M.G; SCILIMATI A. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 22:23(2011), pp. 1985-1993. |
| Abstract: | Kluyveromyces marxianus CBS 6556 growing cell versatility in the enantioselective reduction of ketone-carbonyl functionality to the corresponding alcohols was exploited. In particular, methyl ketones were reduced to (S)-alcohols with ee up to 96%. Longer chain alkyl ketones afford, in the same experimental condition, (R)-alcohols with ee up to 84%. Interestingly, carbon-carbon double and triple bond of ketones can also be reduced in the presence of Kluyveromyces marxianus CBS 6556 yeast. Endocyclic carbonyl functionality, such as 2-tetralone carbonyl, is also quantitatively reduced to its (S)-alcohol with ee = 76%. |
| Handle: | http://hdl.handle.net/11586/133250 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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