Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction

Vitale, Paola; Perna, Filippo; PERRONE M., G; Scilimati, Antonio

doi:10.1016/j.tetasy.2011.11.014

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Kluyveromyces marxianus CBS 6556 growing cell versatility in the enantioselective reduction of ketone-carbonyl functionality to the corresponding alcohols was exploited. In particular, methyl ketones were reduced to (S)-alcohols with ee up to 96%. Longer chain alkyl ketones afford, in the same experimental condition, (R)-alcohols with ee up to 84%. Interestingly, carbon-carbon double and triple bond of ketones can also be reduced in the presence of Kluyveromyces marxianus CBS 6556 yeast. Endocyclic carbonyl functionality, such as 2-tetralone carbonyl, is also quantitatively reduced to its (S)-alcohol with ee = 76%.

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Titolo:	Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction
Autori:	VITALE, PAOLA (Corresponding) PERNA, FILIPPO [Membro del Collaboration Group] PERRONE M. G [Membro del Collaboration Group] SCILIMATI, Antonio [Membro del Collaboration Group] mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2011
Rivista:	TETRAHEDRON-ASYMMETRY
Citazione:	Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction / VITALE P; PERNA F.M; PERRONE M.G; SCILIMATI A. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 22:23(2011), pp. 1985-1993.
Abstract:	Kluyveromyces marxianus CBS 6556 growing cell versatility in the enantioselective reduction of ketone-carbonyl functionality to the corresponding alcohols was exploited. In particular, methyl ketones were reduced to (S)-alcohols with ee up to 96%. Longer chain alkyl ketones afford, in the same experimental condition, (R)-alcohols with ee up to 84%. Interestingly, carbon-carbon double and triple bond of ketones can also be reduced in the presence of Kluyveromyces marxianus CBS 6556 yeast. Endocyclic carbonyl functionality, such as 2-tetralone carbonyl, is also quantitatively reduced to its (S)-alcohol with ee = 76%.
Handle:	http://hdl.handle.net/11586/133250
Appare nelle tipologie:	1.1 Articolo in rivista

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