Enantiomerically pure (R)-β-hydroxy-1,2,3-triazole derivatives, which are important β-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid bacterium (Weissella cibaria C43-11) and a “click” cycloaddition reaction carried out in deep eutectic solvents, under heterogeneous and aerobic conditions at room temperature.

Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous “click” cycloaddition reaction in deep eutectic solvents

Paola Vitale
;
Filippo Maria Perna;Eugenia Messina;Gennaro Agrimi;Isabella Pisano;Vito Capriati
2020

Abstract

Enantiomerically pure (R)-β-hydroxy-1,2,3-triazole derivatives, which are important β-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid bacterium (Weissella cibaria C43-11) and a “click” cycloaddition reaction carried out in deep eutectic solvents, under heterogeneous and aerobic conditions at room temperature.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/285199
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