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EnglishA Deep Eutectic Solvent like choline chloride/glycerol (1:2 mol mol–1) proved to be an effective, sustainablereaction medium to easily synthesize both phenacyl azides andsymmetrical 2,5-diarylpyrazines of interest in pharmacologyand in coordination chemistry. Notable features of our reportinclude: (i) nucleophilic substitution reactions ofα-halo carb-onyl compounds to the corresponding phenacyl azides compatible with the eutectic mixture, (ii) the reduction of phenacylazides toα-amino carbonyl compounds, which undergo spon-taneous dimerisation/cyclisation/aromatisation in the same eu-tectic mixture to provide valuable pyrazines. Telescoped, one-pot, two-steps stoichiometric/catalytic processes have alsobeen successfully developed to furnish 2,5-diarylpyrazines in upto 95 % yield.
| Titolo: | Streamlined Routes to Phenacyl Azides and 2,5-Diarylpyrazines Enabled by Deep Eutectic Solvents | |
| Autori: | CAPRIATI, Vito (Corresponding) | |
| Data di pubblicazione: | 2019 | |
| Rivista: | ||
| Handle: | http://hdl.handle.net/11586/241649 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2019_Phenacyl azides_Pyrazines.pdf | Documento in Versione Editoriale | NON PUBBLICO - Accesso privato/ristretto | Administrator Richiedi una copia |
http://hdl.handle.net/11586/241649
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