IRIS
PERRONE, MARIA GRAZIA
 Distribuzione geografica
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Continente #
NA - Nord America 8.679
AS - Asia 4.160
EU - Europa 2.952
SA - Sud America 1.043
AF - Africa 174
OC - Oceania 33
Continente sconosciuto - Info sul continente non disponibili 3
Totale 17.044
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Nazione #
US - Stati Uniti d'America 8.483
SG - Singapore 1.704
CN - Cina 949
IT - Italia 838
BR - Brasile 814
HK - Hong Kong 495
SE - Svezia 407
RU - Federazione Russa 393
DE - Germania 281
VN - Vietnam 237
FR - Francia 200
GB - Regno Unito 191
FI - Finlandia 168
UA - Ucraina 142
IN - India 126
ID - Indonesia 120
BD - Bangladesh 114
CA - Canada 107
AR - Argentina 78
JP - Giappone 62
TR - Turchia 62
MX - Messico 57
NL - Olanda 56
BE - Belgio 43
CI - Costa d'Avorio 41
IQ - Iraq 39
PL - Polonia 37
ES - Italia 36
CO - Colombia 34
EC - Ecuador 34
ZA - Sudafrica 34
AU - Australia 30
PK - Pakistan 30
IE - Irlanda 28
SA - Arabia Saudita 28
VE - Venezuela 27
UZ - Uzbekistan 26
AT - Austria 25
CL - Cile 21
CZ - Repubblica Ceca 21
PH - Filippine 21
CH - Svizzera 20
MA - Marocco 20
KR - Corea 18
IR - Iran 17
LT - Lituania 17
KE - Kenya 16
PY - Paraguay 16
EG - Egitto 15
MY - Malesia 13
TW - Taiwan 13
AE - Emirati Arabi Uniti 12
AZ - Azerbaigian 12
TN - Tunisia 11
CR - Costa Rica 9
IL - Israele 8
NP - Nepal 8
ET - Etiopia 7
NO - Norvegia 7
PE - Perù 7
GT - Guatemala 6
HU - Ungheria 6
KZ - Kazakistan 6
OM - Oman 6
PS - Palestinian Territory 6
PT - Portogallo 6
RO - Romania 6
UY - Uruguay 6
BG - Bulgaria 5
BO - Bolivia 5
JM - Giamaica 5
LB - Libano 5
SN - Senegal 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
GE - Georgia 3
JO - Giordania 3
KG - Kirghizistan 3
LY - Libia 3
MD - Moldavia 3
MK - Macedonia 3
TZ - Tanzania 3
BW - Botswana 2
BY - Bielorussia 2
CY - Cipro 2
DK - Danimarca 2
GA - Gabon 2
GR - Grecia 2
MN - Mongolia 2
NZ - Nuova Zelanda 2
SI - Slovenia 2
XK - ???statistics.table.value.countryCode.XK??? 2
ZW - Zimbabwe 2
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
BF - Burkina Faso 1
Totale 17.022
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Città #
Ashburn 930
Singapore 903
Fairfield 824
Chandler 592
San Jose 582
Woodbridge 543
Hong Kong 489
Houston 432
Seattle 332
Nyköping 324
Jacksonville 322
Cambridge 315
Ann Arbor 295
Beijing 290
Wilmington 250
Bari 233
Dallas 213
New York 153
Los Angeles 128
Lauterbourg 125
Roxbury 108
Lawrence 106
Nanjing 96
Boardman 85
Sannicandro di Bari 82
Council Bluffs 77
Ho Chi Minh City 74
São Paulo 72
Helsinki 70
Santa Clara 70
Brooklyn 61
Des Moines 61
Munich 58
Princeton 57
Dearborn 51
Buffalo 49
Tokyo 47
Milan 46
Jakarta 45
Hanoi 43
Inglewood 43
Frankfurt am Main 42
Abidjan 41
Brussels 40
Chicago 39
London 38
San Diego 38
Falkenstein 35
Montreal 34
Moscow 33
San Francisco 33
Nanchang 32
Denver 31
Orem 31
Rome 30
Warsaw 30
Jiaxing 27
Atlanta 26
Nuremberg 25
Toronto 25
Dublin 24
Hebei 24
Mexico City 24
Rio de Janeiro 24
Shenyang 24
Tashkent 24
Changsha 23
Florence 22
Phoenix 22
Shanghai 21
Belo Horizonte 20
Johannesburg 19
Stockholm 19
Amsterdam 18
Chennai 18
Manchester 18
The Dalles 18
Brno 17
Columbus 17
Boston 16
Nairobi 16
Poplar 15
Brasília 14
Dhaka 14
Istanbul 14
Bitonto 13
Jeddah 13
Paris 13
Santiago 13
Turku 13
Baghdad 12
Guayaquil 12
Haiphong 12
Madrid 12
New Delhi 12
Pune 12
Wuhan 12
Baku 11
Catania 11
Guangzhou 11
Totale 10.973
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 241
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 211
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 200
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 194
COX-1 Inhibitors: Beyond Structure Toward Therapy 183
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 182
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 180
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 178
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 174
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 172
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 170
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 167
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 167
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 165
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 164
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 164
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 162
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 159
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 157
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 153
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 153
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 152
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 152
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 152
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 151
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 151
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 150
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 149
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 149
Current and emerging applications of fluorine in medicinal chemistry 148
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 146
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 146
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 146
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 145
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 144
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 143
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 142
Update on SAR studies toward new COX-1 selective inhibitors 141
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 138
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 138
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 137
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 134
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 132
Beta 3-adrenoceptor ligand development history through patent review 129
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 127
MODULATORS OF HUMAN MITOCHONDRIAL PROTEASE ClpP ACTIVITY FOR PEDIATRIC DIFFUSE PONTINE GLIOMA TREATMENT 124
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders 124
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 121
A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics 121
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 120
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 119
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 119
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 119
[18F]-P6 AS A CYCLOOXYGENASE-1 TARGETED IMAGING AGENT 118
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 118
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 117
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 116
Cyclooxygenase-1 Inhibition: A Promising Theragnostic Approach for Ovarian Cancer 115
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 115
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 115
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 114
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 112
Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery 110
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 110
STRUCTURAL EVOLUTION OF ONC201-DERIVED COMPOUNDS TARGETING THE MITOCHONDRIAL PROTEASE CLPP FOR PEDIATRIC DIFFUSE MIDLINE GLIOMA H3K27-ALTERED" 109
Selective COX-1 inhibition: a therapeutic target to be reconsidered 109
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 109
Translational Theragnosis of Ovarian Cancer: where do we stand? 108
Zoledronic acid as a novel dual blocker of KIR6.1/2-SUR2 subunits of ATP-sensitive K+ channels: Role in the adverse drug reactions 108
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects 107
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 107
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 106
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 106
Comparative Structural Analysis of hCOX‑1 and oCOX‑1 Isoenzymes 105
Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle 103
Acridone derivatives and small molecules as P-gp inhibitors 102
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 102
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 102
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 99
Three-dimensional structure of human cyclooxygenase (hCOX)-1 98
m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity 97
Ligandi del recettore beta-3 adrenergico e loro uso in terapia 97
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 96
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation 96
Novel hClpP protease activators with potential anticancer activity in DIPG patients 93
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 92
Ovine COX-1 Isoenzyme Bio-production 91
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 90
TARGETING HUMAN MITOCHONDRIAL ClpP AS A NOVEL THERAPEUTIC APPROACH TO H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 90
Up-regulation of b3-adrenergic receptor mRNA in human colon cancer: a preliminary study 90
Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives 90
Genome-Wide Identification and Validation of Gene Expression Biomarkers in the Diagnosis of Ovarian Serous Cystadenocarcinoma 89
Yeast and a novel ADH-mediated biosynthesis of new clofibrate analogues 88
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues 88
Modulation of the activity of human mitochondrial protease complex ClpXP as potential therapeutic strategy for cancer 87
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 86
Repurposing of natural origin compounds as HsClpP inducers to treat diffuse midline glioma (DMG) 86
COX-1 INHIBITORS AS ANTI-PLATELET AGENTS IN COVID-19 86
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 86
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 85
Totale 12.848
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Categoria #
all - tutte 70.510
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 70.510
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202163 0 0 0 0 0 0 0 0 0 0 0 63
2021/2022933 77 113 23 18 41 70 49 50 67 77 129 219
2022/20231.543 200 183 136 121 181 206 15 182 232 21 41 25
2023/2024764 37 93 47 66 55 109 43 22 122 47 22 101
2024/20252.947 121 34 208 92 124 221 402 275 155 159 384 772
2025/20266.754 840 329 559 767 879 385 781 258 783 717 363 93
Totale 17.663