IRIS
PERRONE, MARIA GRAZIA
 Distribuzione geografica
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Continente #
NA - Nord America 9.485
AS - Asia 4.270
EU - Europa 3.644
SA - Sud America 1.073
Continente sconosciuto - Info sul continente non disponibili 630
AF - Africa 179
OC - Oceania 33
Totale 19.314
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Nazione #
US - Stati Uniti d'America 9.222
SG - Singapore 1.715
IT - Italia 1.486
CN - Cina 963
BR - Brasile 827
HK - Hong Kong 499
SE - Svezia 407
RU - Federazione Russa 393
DE - Germania 285
VN - Vietnam 240
FR - Francia 213
GB - Regno Unito 196
BD - Bangladesh 168
FI - Finlandia 168
CA - Canada 155
UA - Ucraina 144
IN - India 128
ID - Indonesia 122
AR - Argentina 83
TR - Turchia 65
JP - Giappone 62
MX - Messico 60
NL - Olanda 58
BE - Belgio 44
CI - Costa d'Avorio 41
CO - Colombia 41
EC - Ecuador 39
ES - Italia 39
IQ - Iraq 39
PL - Polonia 39
ZA - Sudafrica 34
PK - Pakistan 31
SA - Arabia Saudita 31
AU - Australia 30
CH - Svizzera 30
IE - Irlanda 28
VE - Venezuela 27
UZ - Uzbekistan 26
AT - Austria 25
PH - Filippine 22
CL - Cile 21
CZ - Repubblica Ceca 21
MA - Marocco 20
KR - Corea 19
IR - Iran 17
KE - Kenya 17
LT - Lituania 17
MY - Malesia 17
PY - Paraguay 16
EG - Egitto 15
AE - Emirati Arabi Uniti 14
TW - Taiwan 13
AZ - Azerbaigian 12
TN - Tunisia 11
CR - Costa Rica 10
JM - Giamaica 10
IL - Israele 9
NP - Nepal 8
ET - Etiopia 7
GT - Guatemala 7
KZ - Kazakistan 7
NO - Norvegia 7
PE - Perù 7
TH - Thailandia 7
HU - Ungheria 6
OM - Oman 6
PS - Palestinian Territory 6
PT - Portogallo 6
RO - Romania 6
UY - Uruguay 6
BG - Bulgaria 5
BO - Bolivia 5
LB - Libano 5
SN - Senegal 5
TT - Trinidad e Tobago 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
MD - Moldavia 4
MK - Macedonia 4
GE - Georgia 3
HN - Honduras 3
JO - Giordania 3
KG - Kirghizistan 3
LY - Libia 3
TZ - Tanzania 3
XK - ???statistics.table.value.countryCode.XK??? 3
BW - Botswana 2
BY - Bielorussia 2
CG - Congo 2
CY - Cipro 2
DK - Danimarca 2
GA - Gabon 2
GR - Grecia 2
MN - Mongolia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PA - Panama 2
SC - Seychelles 2
SI - Slovenia 2
ZW - Zimbabwe 2
Totale 18.660
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Città #
Ashburn 965
Singapore 911
Fairfield 824
San Jose 711
Chandler 592
Woodbridge 544
Hong Kong 492
Houston 432
Milan 398
Seattle 334
Nyköping 324
Jacksonville 322
Cambridge 315
Beijing 298
Ann Arbor 295
Wilmington 250
Bari 239
Council Bluffs 231
Dallas 219
New York 165
Los Angeles 139
Lauterbourg 125
Rome 122
Roxbury 108
Santa Clara 108
Lawrence 106
Columbus 99
Nanjing 96
Boardman 88
Sannicandro di Bari 82
Ho Chi Minh City 75
São Paulo 75
Helsinki 70
Brooklyn 62
Des Moines 61
Munich 59
Princeton 58
Buffalo 54
Dearborn 51
Tokyo 47
Chicago 46
Jakarta 45
Frankfurt am Main 44
Hanoi 44
Inglewood 43
Abidjan 41
Brussels 40
London 39
San Diego 38
Montreal 36
Denver 35
Falkenstein 35
San Francisco 34
Moscow 33
Nanchang 32
Atlanta 31
Orem 31
Phoenix 31
Turin 31
Vancouver 31
Warsaw 30
Toronto 29
Jiaxing 27
Mexico City 25
Nuremberg 25
Dublin 24
Figino 24
Florence 24
Hebei 24
Rio de Janeiro 24
Shenyang 24
Tashkent 24
Changsha 23
Shanghai 23
Naples 22
Belo Horizonte 20
Amsterdam 19
Chennai 19
Johannesburg 19
Manchester 19
Stockholm 19
Philadelphia 18
The Dalles 18
Brno 17
Nairobi 17
Boston 16
Istanbul 16
Poplar 15
Bern 14
Bitonto 14
Brasília 14
Dhaka 14
Guayaquil 14
Medellín 14
Paris 14
Taranto 14
Bologna 13
Catania 13
Jeddah 13
Madrid 13
Totale 12.054
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 261
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 216
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 210
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 209
COX-1 Inhibitors: Beyond Structure Toward Therapy 199
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 193
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 189
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 186
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 186
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 186
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 181
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 179
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 178
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 175
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 175
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 175
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 174
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 172
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 165
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 164
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 164
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 164
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 164
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 163
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 161
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 160
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 159
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 159
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 156
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 155
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 155
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 155
Current and emerging applications of fluorine in medicinal chemistry 154
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 153
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 152
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 151
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 149
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 148
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 147
MODULATORS OF HUMAN MITOCHONDRIAL PROTEASE ClpP ACTIVITY FOR PEDIATRIC DIFFUSE PONTINE GLIOMA TREATMENT 144
Update on SAR studies toward new COX-1 selective inhibitors 144
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 144
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 143
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 140
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 138
Beta 3-adrenoceptor ligand development history through patent review 136
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 134
Cyclooxygenase-1 Inhibition: A Promising Theragnostic Approach for Ovarian Cancer 130
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders 130
[18F]-P6 AS A CYCLOOXYGENASE-1 TARGETED IMAGING AGENT 129
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 128
STRUCTURAL EVOLUTION OF ONC201-DERIVED COMPOUNDS TARGETING THE MITOCHONDRIAL PROTEASE CLPP FOR PEDIATRIC DIFFUSE MIDLINE GLIOMA H3K27-ALTERED" 126
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 126
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 125
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 125
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 125
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 124
A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics 123
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 122
Three-dimensional structure of human cyclooxygenase (hCOX)-1 121
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 121
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 121
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 121
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects 120
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 120
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 120
Selective COX-1 inhibition: a therapeutic target to be reconsidered 119
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 119
Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery 118
Translational Theragnosis of Ovarian Cancer: where do we stand? 118
Novel hClpP protease activators with potential anticancer activity in DIPG patients 116
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 116
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 116
Three-dimensional structure of human cyclooxygenase (hCOX)-1 115
Zoledronic acid as a novel dual blocker of KIR6.1/2-SUR2 subunits of ATP-sensitive K+ channels: Role in the adverse drug reactions 115
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 114
Genome-Wide Identification and Validation of Gene Expression Biomarkers in the Diagnosis of Ovarian Serous Cystadenocarcinoma 113
Comparative Structural Analysis of hCOX‑1 and oCOX‑1 Isoenzymes 112
Acridone derivatives and small molecules as P-gp inhibitors 109
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation 109
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 108
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 108
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 107
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 106
Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle 106
Up-regulation of b3-adrenergic receptor mRNA in human colon cancer: a preliminary study 103
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 103
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 102
m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity 102
TARGETING HUMAN MITOCHONDRIAL ClpP AS A NOVEL THERAPEUTIC APPROACH TO H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 102
Ligandi del recettore beta-3 adrenergico e loro uso in terapia 102
Modulation of the activity of human mitochondrial protease complex ClpXP as potential therapeutic strategy for cancer 101
Human Caseinolytic Protease P (hClpP) Activity Modulating Agents For The Treatment Of DIPG/DMG 98
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues 98
Ovine COX-1 Isoenzyme Bio-production 98
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 97
Repurposing of natural origin compounds as HsClpP inducers to treat diffuse midline glioma (DMG) 96
Yeast and a novel ADH-mediated biosynthesis of new clofibrate analogues 96
Lipid-modifying agents by yeasts- and a novel ADH-mediated reduction of 3-oxoesters 96
CYP3A4/P-gp sinergistic activity to modulate the absorption and delivery of xenobiotics 95
Totale 13.855
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Categoria #
all - tutte 76.412
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.412
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022743 0 0 23 18 41 70 49 50 67 77 129 219
2022/20231.543 200 183 136 121 181 206 15 182 232 21 41 25
2023/2024764 37 93 47 66 55 109 43 22 122 47 22 101
2024/20252.947 121 34 208 92 124 221 402 275 155 159 384 772
2025/20267.387 840 329 559 767 879 385 781 258 783 717 363 726
2026/20271.018 384 357 277 0 0 0 0 0 0 0 0 0
Totale 19.314