IRIS
PERRONE, MARIA GRAZIA
 Distribuzione geografica
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Continente #
NA - Nord America 5.750
EU - Europa 1.451
AS - Asia 838
SA - Sud America 22
OC - Oceania 9
AF - Africa 2
Continente sconosciuto - Info sul continente non disponibili 1
Totale 8.073
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Nazione #
US - Stati Uniti d'America 5.727
CN - Cina 486
IT - Italia 460
SE - Svezia 386
SG - Singapore 224
DE - Germania 133
UA - Ucraina 131
FI - Finlandia 96
GB - Regno Unito 79
ID - Indonesia 57
BE - Belgio 36
FR - Francia 30
IN - India 24
RU - Federazione Russa 24
CA - Canada 21
IE - Irlanda 20
CZ - Repubblica Ceca 19
JP - Giappone 13
IR - Iran 12
CL - Cile 9
NL - Olanda 9
AU - Australia 8
VN - Vietnam 7
BR - Brasile 6
CH - Svizzera 4
HU - Ungheria 4
KR - Corea 4
PE - Perù 4
AT - Austria 3
BG - Bulgaria 3
ES - Italia 3
IL - Israele 3
IQ - Iraq 3
AR - Argentina 2
EG - Egitto 2
GR - Grecia 2
LT - Lituania 2
MX - Messico 2
PL - Polonia 2
RO - Romania 2
TR - Turchia 2
DK - Danimarca 1
EE - Estonia 1
EU - Europa 1
MN - Mongolia 1
NZ - Nuova Zelanda 1
PK - Pakistan 1
SA - Arabia Saudita 1
SK - Slovacchia (Repubblica Slovacca) 1
VE - Venezuela 1
Totale 8.073
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Città #
Fairfield 824
Chandler 605
Woodbridge 543
Houston 421
Ashburn 387
Nyköping 325
Seattle 324
Jacksonville 317
Cambridge 311
Ann Arbor 294
Wilmington 249
Bari 177
Singapore 168
Roxbury 108
Lawrence 107
Beijing 102
Nanjing 95
Sannicandro di Bari 82
New York 71
Boardman 61
Des Moines 61
Princeton 57
Dearborn 51
Inglewood 43
San Diego 36
Brussels 34
Brooklyn 33
Nanchang 30
Jiaxing 27
Hebei 24
Shenyang 24
Santa Clara 23
Changsha 20
Munich 20
Dublin 19
Brno 17
Milan 17
Shanghai 17
London 16
Bitonto 13
Paris 12
Toronto 12
Helsinki 11
Wuhan 11
Frankfurt am Main 10
Los Angeles 10
Tokyo 10
Washington 10
Ardabil 9
Falls Church 9
Pune 9
Redwood City 9
Tianjin 9
Hefei 8
Norwalk 8
San Francisco 8
Augusta 7
Dong Ket 7
Guangzhou 7
San Mateo 7
Santiago 7
Florence 6
Rome 6
Turin 6
Wuxi 6
Adelfia 5
Redmond 5
Adelaide 4
Arequipa 4
Casoria 4
Chengdu 4
Chicago 4
Edinburgh 4
Indiana 4
Jinan 4
Kansas City 4
Kilburn 4
Kornye 4
Kunming 4
Lincoln 4
Marseille 4
Monmouth Junction 4
Valenzano 4
Valparaiso 4
Wallsend 4
Coimbatore 3
Detroit 3
Fano 3
Jinhua 3
Massafra 3
Napoli 3
Racale 3
Sofia 3
Stanford 3
Sulaymaniyah 3
São Paulo 3
Tel Aviv 3
Triggiano 3
Acquaviva delle Fonti 2
Alexandria 2
Totale 6.492
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 147
COX-1 Inhibitors: Beyond Structure Toward Therapy 131
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 128
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 124
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 120
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 120
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 119
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 119
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 117
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 117
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 111
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 111
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 104
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 104
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 103
Update on SAR studies toward new COX-1 selective inhibitors 102
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 101
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 99
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 99
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 99
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 98
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 97
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 96
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 96
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 96
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 95
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 94
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 93
Current and emerging applications of fluorine in medicinal chemistry 93
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 93
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 92
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 91
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 90
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 88
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 88
Selective COX-1 inhibition: a therapeutic target to be reconsidered 87
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 86
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 85
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 84
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 84
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 83
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 81
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 80
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 79
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 79
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 79
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 76
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 76
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 73
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 73
Beta 3-adrenoceptor ligand development history through patent review 72
null 69
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 68
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 68
null 64
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues 63
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 63
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 63
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 62
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 61
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 60
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 60
Acridone derivatives and small molecules as P-gp inhibitors 59
Ligandi del recettore beta-3 adrenergico e loro uso in terapia 59
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 59
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 59
Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives 58
[18F]-P6 AS A CYCLOOXYGENASE-1 TARGETED IMAGING AGENT 57
Lipid-modifying agents by yeasts- and a novel ADH-mediated reduction of 3-oxoesters 57
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 57
Lipid-modifying agents by yeasts- and a novel ADH-mediated reduction of 3-oxoesters 55
Up-regulation of b3-adrenergic receptor mRNA in human colon cancer: a preliminary study 55
A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics 54
Mucoadhesive Properties and Interaction with P-glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study 53
CYP3A4/P-gp sinergistic activity to modulate the absorption and delivery of xenobiotics 52
Bioassisted synthesis of 3-hydroxyacids resembling antilipidemic clofibric acid molecular structure 52
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation 52
Isoxazole and pyrazole core in COX-1 inhibitors 51
Yeast and a novel ADH-mediated biosynthesis of new clofibrate analogues 51
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 51
SAR study on Arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity 50
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 49
null 48
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders 48
β 3 -Adrenoceptor agonists and (Antagonists as) inverse agonists. History, perspective, constitutive activity, and stereospecific binding 47
Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle 47
null 45
Why PB28 Could Be a Covid 2019 Game Changer? 44
Three-dimensional structure of human cyclooxygenase (hCOX)-1 44
Method of screening for therapeutic compounds useful in detoxifying central nervous system from beta-amyloid peptide 43
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 43
Effects of carvacrol, a major constituents of origanum essential oil, on the central nervous system of male rats 42
Receptor drug interaction: europium employment for studying the biochemical pathway of GPRC activation 41
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 41
null 41
Neuroinflammation and Microglial Constitutive COX-1 Inhibition 41
Ovine COX-1 Isoenzyme Bio-production 41
Receptor-drug interaction: Europium employment for studying the biochemical pathway of G-protein-coupled recepyor activation 40
Selective inhibition of cyclooxygenase (COX) isoenzymes and neuroinflammation 40
Synthesis and pharmacological characterization of new beta 3-adrenergic agonists?? 40
Totale 7.519
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Categoria #
all - tutte 38.979
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.979
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.350 0 0 0 0 189 134 197 169 219 183 187 72
2020/20211.223 141 75 118 79 123 40 80 88 120 183 113 63
2021/2022933 77 113 23 18 41 70 49 50 67 77 129 219
2022/20231.569 202 187 139 123 184 207 15 188 236 21 42 25
2023/2024771 40 96 48 66 55 109 43 22 122 47 22 101
2024/2025550 121 34 208 93 94 0 0 0 0 0 0 0
Totale 8.545