IRIS
PERRONE, MARIA GRAZIA
 Distribuzione geografica
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Continente #
NA - Nord America 10.835
AS - Asia 4.321
EU - Europa 3.927
SA - Sud America 1.087
Continente sconosciuto - Info sul continente non disponibili 660
AF - Africa 194
OC - Oceania 33
Totale 21.057
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Nazione #
US - Stati Uniti d'America 10.410
SG - Singapore 1.718
IT - Italia 1.648
CN - Cina 967
BR - Brasile 840
HK - Hong Kong 499
RU - Federazione Russa 437
SE - Svezia 407
DE - Germania 291
VN - Vietnam 240
GB - Regno Unito 234
FR - Francia 219
CA - Canada 208
BD - Bangladesh 174
FI - Finlandia 168
UA - Ucraina 146
IN - India 129
ID - Indonesia 123
AR - Argentina 83
TR - Turchia 66
JP - Giappone 62
MX - Messico 61
NL - Olanda 61
BE - Belgio 46
PL - Polonia 43
CI - Costa d'Avorio 41
CO - Colombia 41
ES - Italia 40
EC - Ecuador 39
IL - Israele 39
IQ - Iraq 39
ZA - Sudafrica 34
IE - Irlanda 32
PK - Pakistan 31
SA - Arabia Saudita 31
AU - Australia 30
CH - Svizzera 30
CR - Costa Rica 29
VE - Venezuela 28
AT - Austria 26
UZ - Uzbekistan 26
PH - Filippine 23
CL - Cile 21
CZ - Repubblica Ceca 21
LT - Lituania 21
SV - El Salvador 21
MA - Marocco 20
KR - Corea 19
GT - Guatemala 18
MY - Malesia 18
CW - ???statistics.table.value.countryCode.CW??? 17
IR - Iran 17
KE - Kenya 17
PY - Paraguay 16
SC - Seychelles 16
TT - Trinidad e Tobago 16
EG - Egitto 15
AE - Emirati Arabi Uniti 14
HN - Honduras 14
NI - Nicaragua 13
TW - Taiwan 13
AZ - Azerbaigian 12
JM - Giamaica 12
TN - Tunisia 11
NP - Nepal 8
PR - Porto Rico 8
TH - Thailandia 8
ET - Etiopia 7
KZ - Kazakistan 7
NO - Norvegia 7
PE - Perù 7
HU - Ungheria 6
OM - Oman 6
PS - Palestinian Territory 6
PT - Portogallo 6
RO - Romania 6
UY - Uruguay 6
BG - Bulgaria 5
BO - Bolivia 5
DO - Repubblica Dominicana 5
LB - Libano 5
SN - Senegal 5
BS - Bahamas 4
DZ - Algeria 4
EE - Estonia 4
GP - Guadalupe 4
GR - Grecia 4
MD - Moldavia 4
MK - Macedonia 4
AM - Armenia 3
BB - Barbados 3
DK - Danimarca 3
GE - Georgia 3
JO - Giordania 3
KG - Kirghizistan 3
LY - Libia 3
NG - Nigeria 3
TZ - Tanzania 3
XK - ???statistics.table.value.countryCode.XK??? 3
AG - Antigua e Barbuda 2
Totale 20.374
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Città #
Ashburn 1.209
Singapore 911
Fairfield 824
San Jose 822
Chandler 592
Woodbridge 544
Hong Kong 492
Houston 433
Milan 419
Seattle 335
Council Bluffs 326
Nyköping 324
Jacksonville 322
Cambridge 316
Beijing 298
Ann Arbor 295
Bari 256
Wilmington 250
Dallas 224
New York 192
Los Angeles 159
Rome 136
Santa Clara 132
Lauterbourg 125
Roxbury 108
Lawrence 106
Columbus 100
Nanjing 96
Boardman 90
São Paulo 85
Sannicandro di Bari 82
Ho Chi Minh City 75
Brooklyn 70
Helsinki 70
Des Moines 61
Munich 59
Princeton 59
Buffalo 55
Chicago 52
Dearborn 52
Washington 49
Tokyo 47
Frankfurt am Main 45
Jakarta 45
Hanoi 44
London 44
Inglewood 43
Montreal 42
Abidjan 41
Atlanta 41
Brussels 41
Vancouver 39
North Bergen 38
San Diego 38
San Francisco 38
Toronto 38
Denver 36
Phoenix 36
Falkenstein 35
Moscow 33
Turin 33
Nanchang 32
Naples 31
Orem 31
Warsaw 30
Florence 29
Figino 28
Jiaxing 27
Mexico City 25
Nuremberg 25
Dublin 24
Hebei 24
Rio de Janeiro 24
Shenyang 24
Tashkent 24
Changsha 23
San José 23
Shanghai 23
Philadelphia 22
Belo Horizonte 20
Amsterdam 19
Chennai 19
Johannesburg 19
Manchester 19
San Salvador 19
Stockholm 19
The Dalles 18
Brno 17
Nairobi 17
Boston 16
Istanbul 16
Willemstad 16
Bologna 15
Catania 15
Dhaka 15
Palermo 15
Poplar 15
Bern 14
Bitonto 14
Brasília 14
Totale 12.822
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 275
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 235
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 226
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 219
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 219
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 217
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 209
COX-1 Inhibitors: Beyond Structure Toward Therapy 205
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 195
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 195
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 195
Novel hClpP protease activators with potential anticancer activity in DIPG patients 194
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 191
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 190
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 186
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 185
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 184
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 183
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 179
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 174
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 174
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 173
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 172
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 171
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 170
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 168
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 167
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 166
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 165
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 165
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 164
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 160
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 160
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 160
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 158
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 158
Current and emerging applications of fluorine in medicinal chemistry 158
MODULATORS OF HUMAN MITOCHONDRIAL PROTEASE ClpP ACTIVITY FOR PEDIATRIC DIFFUSE PONTINE GLIOMA TREATMENT 157
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 157
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 155
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 155
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 153
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 153
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 151
Cyclooxygenase-1 Inhibition: A Promising Theragnostic Approach for Ovarian Cancer 149
Update on SAR studies toward new COX-1 selective inhibitors 148
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 143
Beta 3-adrenoceptor ligand development history through patent review 141
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 141
STRUCTURAL EVOLUTION OF ONC201-DERIVED COMPOUNDS TARGETING THE MITOCHONDRIAL PROTEASE CLPP FOR PEDIATRIC DIFFUSE MIDLINE GLIOMA H3K27-ALTERED" 140
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders 138
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 137
Genome-Wide Identification and Validation of Gene Expression Biomarkers in the Diagnosis of Ovarian Serous Cystadenocarcinoma 136
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects 135
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 133
[18F]-P6 AS A CYCLOOXYGENASE-1 TARGETED IMAGING AGENT 132
Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery 130
Translational Theragnosis of Ovarian Cancer: where do we stand? 130
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 130
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 129
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 129
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 129
A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics 129
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 128
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 128
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 128
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 128
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 128
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 126
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 126
Three-dimensional structure of human cyclooxygenase (hCOX)-1 126
Three-dimensional structure of human cyclooxygenase (hCOX)-1 125
Selective COX-1 inhibition: a therapeutic target to be reconsidered 125
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 125
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 125
Comparative Structural Analysis of hCOX‑1 and oCOX‑1 Isoenzymes 123
Zoledronic acid as a novel dual blocker of KIR6.1/2-SUR2 subunits of ATP-sensitive K+ channels: Role in the adverse drug reactions 122
Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes 121
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 120
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 117
Repurposing of natural origin compounds as HsClpP inducers to treat diffuse midline glioma (DMG) 116
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 115
m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity 113
Neuroinflammation and Microglial Constitutive COX-1 Inhibition 113
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 113
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation 113
Ovine COX-1 Isoenzyme Bio-production 113
COX-1 INHIBITORS AS ANTI-PLATELET AGENTS IN COVID-19 112
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 112
Acridone derivatives and small molecules as P-gp inhibitors 111
Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle 110
Human Caseinolytic Protease P (hClpP) Activity Modulating Agents For The Treatment Of DIPG/DMG 109
Pediatric Diffuse Midline Glioma H3K27-Altered: From Developmental Origins to Therapeutic Challenges 109
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 109
A Simplified Direct O2 Consumption-Based Assay to Test COX Inhibition 109
TARGETING HUMAN MITOCHONDRIAL ClpP AS A NOVEL THERAPEUTIC APPROACH TO H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 107
Up-regulation of b3-adrenergic receptor mRNA in human colon cancer: a preliminary study 107
CHALLENGE TRANSABILITY OF “IN VITRO” TO “IN VIVO”: GENE-EXPRESSION BIOMARKERS AND FLUORESCENT IMAGE-GUIDED SURGERY PROBES IDENTIFICATION FOR OVARIAN CANCER 107
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 106
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 105
Totale 14.855
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Categoria #
all - tutte 82.145
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 82.145
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022702 0 0 0 0 41 70 49 50 67 77 129 219
2022/20231.543 200 183 136 121 181 206 15 182 232 21 41 25
2023/2024764 37 93 47 66 55 109 43 22 122 47 22 101
2024/20252.947 121 34 208 92 124 221 402 275 155 159 384 772
2025/20267.387 840 329 559 767 879 385 781 258 783 717 363 726
2026/20272.761 384 357 639 1.124 257 0 0 0 0 0 0 0
Totale 21.057