IRIS
PERRONE, MARIA GRAZIA
 Distribuzione geografica
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Continente #
NA - Nord America 8.343
AS - Asia 4.071
EU - Europa 2.861
SA - Sud America 1.042
AF - Africa 174
OC - Oceania 33
Continente sconosciuto - Info sul continente non disponibili 3
Totale 16.527
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Nazione #
US - Stati Uniti d'America 8.172
SG - Singapore 1.679
CN - Cina 927
BR - Brasile 813
IT - Italia 761
HK - Hong Kong 488
SE - Svezia 407
RU - Federazione Russa 393
DE - Germania 281
VN - Vietnam 236
FR - Francia 200
GB - Regno Unito 188
FI - Finlandia 168
UA - Ucraina 142
IN - India 126
ID - Indonesia 120
CA - Canada 90
BD - Bangladesh 84
AR - Argentina 78
TR - Turchia 62
JP - Giappone 61
NL - Olanda 55
MX - Messico 53
BE - Belgio 43
CI - Costa d'Avorio 41
IQ - Iraq 39
PL - Polonia 37
CO - Colombia 34
EC - Ecuador 34
ZA - Sudafrica 34
ES - Italia 31
AU - Australia 30
PK - Pakistan 29
IE - Irlanda 28
SA - Arabia Saudita 27
VE - Venezuela 27
UZ - Uzbekistan 26
AT - Austria 25
CL - Cile 21
CZ - Repubblica Ceca 21
PH - Filippine 21
MA - Marocco 20
CH - Svizzera 18
KR - Corea 18
IR - Iran 17
LT - Lituania 17
KE - Kenya 16
PY - Paraguay 16
EG - Egitto 15
MY - Malesia 13
TW - Taiwan 13
AE - Emirati Arabi Uniti 12
AZ - Azerbaigian 11
TN - Tunisia 11
IL - Israele 8
NP - Nepal 8
CR - Costa Rica 7
ET - Etiopia 7
NO - Norvegia 7
PE - Perù 7
HU - Ungheria 6
KZ - Kazakistan 6
OM - Oman 6
PS - Palestinian Territory 6
RO - Romania 6
UY - Uruguay 6
BG - Bulgaria 5
BO - Bolivia 5
GT - Guatemala 5
JM - Giamaica 5
LB - Libano 5
SN - Senegal 5
DO - Repubblica Dominicana 4
DZ - Algeria 4
PT - Portogallo 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
GE - Georgia 3
JO - Giordania 3
KG - Kirghizistan 3
LY - Libia 3
MK - Macedonia 3
TZ - Tanzania 3
BW - Botswana 2
BY - Bielorussia 2
CY - Cipro 2
DK - Danimarca 2
GA - Gabon 2
GR - Grecia 2
MD - Moldavia 2
MN - Mongolia 2
NZ - Nuova Zelanda 2
SI - Slovenia 2
XK - ???statistics.table.value.countryCode.XK??? 2
ZW - Zimbabwe 2
AL - Albania 1
AM - Armenia 1
AO - Angola 1
BB - Barbados 1
BF - Burkina Faso 1
Totale 16.506
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Città #
Ashburn 903
Singapore 893
Fairfield 824
Chandler 592
Woodbridge 543
San Jose 519
Hong Kong 482
Houston 432
Seattle 332
Nyköping 324
Jacksonville 320
Cambridge 315
Ann Arbor 295
Beijing 285
Wilmington 250
Bari 221
Dallas 205
New York 135
Lauterbourg 125
Los Angeles 123
Roxbury 108
Lawrence 106
Nanjing 96
Sannicandro di Bari 82
Council Bluffs 73
Ho Chi Minh City 73
São Paulo 72
Helsinki 70
Boardman 66
Santa Clara 63
Brooklyn 61
Des Moines 61
Munich 58
Princeton 57
Dearborn 51
Tokyo 46
Jakarta 45
Hanoi 43
Inglewood 43
Buffalo 42
Frankfurt am Main 42
Abidjan 41
Brussels 40
Milan 40
Chicago 39
San Diego 37
London 36
Falkenstein 35
Moscow 33
Nanchang 32
San Francisco 31
Orem 30
Warsaw 30
Denver 29
Montreal 29
Jiaxing 27
Nuremberg 25
Dublin 24
Hebei 24
Rio de Janeiro 24
Shenyang 24
Tashkent 24
Changsha 23
Rome 23
Atlanta 22
Florence 22
Toronto 22
Belo Horizonte 20
Mexico City 20
Shanghai 20
Johannesburg 19
Stockholm 19
Amsterdam 18
Chennai 18
Manchester 18
Phoenix 18
The Dalles 18
Brno 17
Columbus 17
Nairobi 16
Boston 15
Poplar 15
Brasília 14
Istanbul 14
Bitonto 13
Dhaka 13
Paris 13
Santiago 13
Turku 13
Baghdad 12
Guayaquil 12
Haiphong 12
Jeddah 12
New Delhi 12
Pune 12
Wuhan 12
Guangzhou 11
Medellín 11
Mumbai 11
Porto Alegre 11
Totale 10.731
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Nome #
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 236
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 202
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 197
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 191
COX-1 Inhibitors: Beyond Structure Toward Therapy 180
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 178
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 176
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 175
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 173
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 164
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 163
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 163
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 162
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 161
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 160
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 159
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 157
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid 153
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 152
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 150
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 150
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 149
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 148
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 148
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 147
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 147
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 146
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 145
Current and emerging applications of fluorine in medicinal chemistry 145
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 144
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 144
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 143
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 142
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 142
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 140
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 140
Update on SAR studies toward new COX-1 selective inhibitors 137
In vitro evaluation of glycol chitosan based formulations as oral delivery systems for efflux pump inhibition 136
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 136
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 134
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 133
Beta 3-adrenoceptor ligand development history through patent review 128
A further pocket or conformational plasticity by mapping COX-1 catalytic site through modified-mofezolac structure-inhibitory activity relationships and their antiplatelet behavior 127
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 122
Cyclooxygenase Inhibition Safety and Efficacy in Inflammation-Based Psychiatric Disorders 122
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 120
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 119
A Combined HPLC and LC-MS Approach for Evaluating Drug Stability in Elastomeric Devices: A Challenge for the Sustainability in Pharmacoeconomics 119
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 117
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 117
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 117
[18F]-P6 AS A CYCLOOXYGENASE-1 TARGETED IMAGING AGENT 116
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 116
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 116
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 115
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 114
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 112
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 111
MODULATORS OF HUMAN MITOCHONDRIAL PROTEASE ClpP ACTIVITY FOR PEDIATRIC DIFFUSE PONTINE GLIOMA TREATMENT 110
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 110
Selective COX-1 inhibition: a therapeutic target to be reconsidered 109
Vascular Toxicity Risk Assessment of MC18 and MC70, Novel Potential Diagnostic Tools for In Vivo PET Studies 108
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 108
Cyclooxygenase-1 Inhibition: A Promising Theragnostic Approach for Ovarian Cancer 107
Zoledronic acid as a novel dual blocker of KIR6.1/2-SUR2 subunits of ATP-sensitive K+ channels: Role in the adverse drug reactions 107
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 106
Fluorescent imaging probes for in vivo ovarian cancer targeted detection and surgery 105
Translational Theragnosis of Ovarian Cancer: where do we stand? 105
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 104
STRUCTURAL EVOLUTION OF ONC201-DERIVED COMPOUNDS TARGETING THE MITOCHONDRIAL PROTEASE CLPP FOR PEDIATRIC DIFFUSE MIDLINE GLIOMA H3K27-ALTERED" 102
Comparative Structural Analysis of hCOX‑1 and oCOX‑1 Isoenzymes 102
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 102
Selective κ Opioid Antagonists nor-BNI, GNTI and JDTic Have Low Affinities for Non-Opioid Receptors and Transporters 102
Bisphosphonates Targeting Ion Channels and Musculoskeletal Effects 101
Acridone derivatives and small molecules as P-gp inhibitors 100
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 99
Ligandi del recettore beta-3 adrenergico e loro uso in terapia 97
Myogenic effect of SP-1f and SP-1h two novel 3-adrenoceptor (3-AR) agonists in human colonic circular smooth muscle 96
Three-dimensional structure of human cyclooxygenase (hCOX)-1 96
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 95
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 94
MC225, a Novel Probe for P-glycoprotein PET imaging at the Blood-Brain Barrier: in vitro cardivascular safety evaluation 94
m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity 92
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 90
Substrates, inhibitors and activators of P-glycoprotein: candidates for radiolabeling and imaging perspectives 90
Up-regulation of b3-adrenergic receptor mRNA in human colon cancer: a preliminary study 88
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues 88
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 87
TARGETING HUMAN MITOCHONDRIAL ClpP AS A NOVEL THERAPEUTIC APPROACH TO H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 87
Yeast and a novel ADH-mediated biosynthesis of new clofibrate analogues 85
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 85
Ovine COX-1 Isoenzyme Bio-production 85
Genome-Wide Identification and Validation of Gene Expression Biomarkers in the Diagnosis of Ovarian Serous Cystadenocarcinoma 84
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 84
CYP3A4/P-gp sinergistic activity to modulate the absorption and delivery of xenobiotics 84
Lipid-modifying agents by yeasts- and a novel ADH-mediated reduction of 3-oxoesters 84
COX-1 INHIBITORS AS ANTI-PLATELET AGENTS IN COVID-19 83
A Simplified Direct O2 Consumption-Based Assay to Test COX Inhibition 83
Isoxazole and pyrazole core in COX-1 inhibitors 82
Totale 12.545
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Categoria #
all - tutte 67.271
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.271
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021359 0 0 0 0 0 0 0 0 0 183 113 63
2021/2022933 77 113 23 18 41 70 49 50 67 77 129 219
2022/20231.543 200 183 136 121 181 206 15 182 232 21 41 25
2023/2024764 37 93 47 66 55 109 43 22 122 47 22 101
2024/20252.947 121 34 208 92 124 221 402 275 155 159 384 772
2025/20266.219 840 329 559 767 879 385 781 258 783 638 0 0
Totale 17.128