Reduction of oxoesters 1b-d and 1f,g in the presence of different yeast strains (Saccharomyces cerevisiae DSM 11285, S. cerevisiae CBS 7336, Cryptococcus curvatus ATCC 20509, Candida bombicola ATCC 22214, Trigonopsis variabilis DSM 70714, Kluyveromyces marxianus CBS 6556) affords hydroxy esters 2b-d and 2f,g with diastereoisomeric excesses (de) up to >99%. Hydrolytic enzyme(s) contained in the yeasts catalyzed to some extent the hydrolysis of the oxoesters to the corresponding acids, which undergo decarboxylation followed by reduction of the carbonyl moiety. © 2005 Elsevier Ltd. All rights reserved.
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues
Perrone, Maria Grazia;SANTANDREA, ERNESTO;Scilimati, Antonio;Tortorella, Vincenzo
2005-01-01
Abstract
Reduction of oxoesters 1b-d and 1f,g in the presence of different yeast strains (Saccharomyces cerevisiae DSM 11285, S. cerevisiae CBS 7336, Cryptococcus curvatus ATCC 20509, Candida bombicola ATCC 22214, Trigonopsis variabilis DSM 70714, Kluyveromyces marxianus CBS 6556) affords hydroxy esters 2b-d and 2f,g with diastereoisomeric excesses (de) up to >99%. Hydrolytic enzyme(s) contained in the yeasts catalyzed to some extent the hydrolysis of the oxoesters to the corresponding acids, which undergo decarboxylation followed by reduction of the carbonyl moiety. © 2005 Elsevier Ltd. All rights reserved.File in questo prodotto:
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