IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 8.832
EU - Europa 3.622
AS - Asia 3.533
SA - Sud America 920
Continente sconosciuto - Info sul continente non disponibili 438
AF - Africa 136
OC - Oceania 19
Totale 17.500
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Nazione #
US - Stati Uniti d'America 8.573
SG - Singapore 1.386
IT - Italia 1.049
CN - Cina 820
BR - Brasile 746
DE - Germania 645
RU - Federazione Russa 463
SE - Svezia 445
HK - Hong Kong 404
GB - Regno Unito 312
VN - Vietnam 269
FR - Francia 185
CA - Canada 171
FI - Finlandia 149
BD - Bangladesh 119
IN - India 105
UA - Ucraina 84
ID - Indonesia 74
AR - Argentina 65
IQ - Iraq 53
AT - Austria 45
JP - Giappone 45
MX - Messico 41
PL - Polonia 40
CI - Costa d'Avorio 39
NL - Olanda 35
PK - Pakistan 33
CO - Colombia 32
IE - Irlanda 30
EC - Ecuador 27
ES - Italia 26
BE - Belgio 25
ZA - Sudafrica 25
TR - Turchia 22
EG - Egitto 21
SA - Arabia Saudita 21
TW - Taiwan 20
UZ - Uzbekistan 20
CZ - Repubblica Ceca 19
VE - Venezuela 17
AU - Australia 16
MY - Malesia 16
CL - Cile 14
MA - Marocco 14
PH - Filippine 14
IR - Iran 12
AE - Emirati Arabi Uniti 11
CR - Costa Rica 10
KR - Corea 10
JO - Giordania 9
LT - Lituania 9
RO - Romania 9
AZ - Azerbaigian 7
BO - Bolivia 7
CH - Svizzera 7
IL - Israele 7
PY - Paraguay 7
TH - Thailandia 7
TN - Tunisia 7
DK - Danimarca 6
DZ - Algeria 6
KE - Kenya 6
KG - Kirghizistan 6
KZ - Kazakistan 6
PS - Palestinian Territory 6
SK - Slovacchia (Repubblica Slovacca) 6
ET - Etiopia 5
GT - Guatemala 5
JM - Giamaica 5
OM - Oman 5
SY - Repubblica araba siriana 5
TT - Trinidad e Tobago 5
AL - Albania 4
LB - Libano 4
MN - Mongolia 4
NP - Nepal 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BB - Barbados 3
BG - Bulgaria 3
EU - Europa 3
HN - Honduras 3
HU - Ungheria 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
ZW - Zimbabwe 3
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
BY - Bielorussia 2
GD - Grenada 2
GE - Georgia 2
GP - Guadalupe 2
GR - Grecia 2
IM - Isola di Man 2
MD - Moldavia 2
NI - Nicaragua 2
PE - Perù 2
RS - Serbia 2
SC - Seychelles 2
SV - El Salvador 2
UY - Uruguay 2
Totale 17.038
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Città #
Fairfield 879
Ashburn 743
Singapore 739
Chandler 539
Los Angeles 529
San Jose 504
Woodbridge 463
Houston 449
Hong Kong 389
Seattle 362
Milan 316
Nyköping 309
Wilmington 302
Beijing 301
Cambridge 290
Ann Arbor 267
Council Bluffs 218
Dallas 200
Bari 190
Jacksonville 186
New York 146
Munich 136
Lauterbourg 121
Rome 108
Lawrence 98
Roxbury 98
Boardman 95
Montréal 88
Nanjing 85
Santa Clara 84
Brooklyn 74
São Paulo 72
Mcallen 68
Ho Chi Minh City 66
Des Moines 59
Chicago 57
Columbus 57
Helsinki 53
Princeton 53
Buffalo 51
Falkenstein 47
Jakarta 47
Hanoi 45
Dong Ket 44
London 43
San Diego 41
Inglewood 40
Abidjan 39
Moscow 39
Tokyo 39
Dublin 30
Warsaw 30
Turin 29
Hebei 28
Phoenix 28
Denver 27
Turku 26
Figino 25
Frankfurt am Main 25
Rio de Janeiro 25
Langenzersdorf 22
Orem 22
Paris 22
The Dalles 22
Jiaxing 21
Montreal 21
Toronto 21
Sannicandro di Bari 20
Shenyang 20
Brussels 19
North Bergen 19
Tashkent 19
Redwood City 18
San Francisco 18
Naples 17
Amsterdam 16
Atlanta 16
Baghdad 16
Mexico City 16
Nanchang 16
Stockholm 16
Belo Horizonte 15
Brasília 15
Falls Church 15
Florence 15
Tianjin 15
Boston 14
Changsha 14
Salt Lake City 14
Vienna 14
Brno 13
Chennai 13
Nuremberg 13
Philadelphia 13
Curitiba 12
Dhaka 12
Poplar 12
Shanghai 12
Da Nang 11
Dearborn 11
Totale 11.191
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Nome #
ABC pumps and their role in active drug transport 417
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 252
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 235
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 226
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 225
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 224
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 222
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 216
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 216
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 214
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 210
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 208
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 195
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 195
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 191
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 190
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 188
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 187
An updated patent review on P-glycoprotein inhibitors (2011-2018) 187
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 186
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 186
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 185
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 182
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 178
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 176
Is the sigma-2 receptor a histone binding protein? 175
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 175
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 173
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 173
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 173
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 172
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 169
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 168
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 167
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 165
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 165
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 164
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 164
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 161
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 160
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 160
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 159
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 155
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 155
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 155
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 153
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 153
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 149
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 149
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 148
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 147
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 146
An innovative small molecule for promoting neuroreparative strategies 145
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 144
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 141
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 140
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 140
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 139
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 133
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 133
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 130
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 129
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 129
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 127
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 126
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 124
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 124
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 120
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 120
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 120
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 120
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 120
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 119
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 117
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 117
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 116
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 116
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 114
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 108
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 108
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 106
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 106
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 106
Small and innovative molecules as new strategy to revert MDR 105
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 104
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 102
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 98
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 97
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 96
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 94
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 94
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 93
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 91
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 91
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 89
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 88
Mucoadhesive Properties and Interaction with P-glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study 88
ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators 87
DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues 87
Totale 15.103
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Categoria #
all - tutte 67.214
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.214
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022811 0 0 23 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20265.855 647 286 557 648 612 342 620 174 549 567 197 656
2026/20271.021 581 302 138 0 0 0 0 0 0 0 0 0
Totale 17.500