IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 6.863
AS - Asia 2.653
EU - Europa 2.653
SA - Sud America 745
AF - Africa 86
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 7
Totale 13.021
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Nazione #
US - Stati Uniti d'America 6.679
SG - Singapore 1.092
CN - Cina 720
BR - Brasile 650
DE - Germania 608
RU - Federazione Russa 455
SE - Svezia 440
IT - Italia 366
HK - Hong Kong 362
GB - Regno Unito 291
VN - Vietnam 180
CA - Canada 135
FI - Finlandia 118
UA - Ucraina 78
FR - Francia 64
IN - India 64
ID - Indonesia 55
AT - Austria 45
AR - Argentina 40
CI - Costa d'Avorio 38
PL - Polonia 35
IE - Irlanda 29
JP - Giappone 29
BD - Bangladesh 28
MX - Messico 26
IQ - Iraq 25
BE - Belgio 22
NL - Olanda 20
EC - Ecuador 18
CZ - Repubblica Ceca 17
ES - Italia 16
EG - Egitto 13
TW - Taiwan 13
AU - Australia 12
ZA - Sudafrica 12
IR - Iran 11
CO - Colombia 10
CL - Cile 9
LT - Lituania 9
RO - Romania 9
TR - Turchia 8
UZ - Uzbekistan 8
AE - Emirati Arabi Uniti 7
KR - Corea 7
MA - Marocco 7
DK - Danimarca 6
IL - Israele 6
PY - Paraguay 6
SA - Arabia Saudita 6
VE - Venezuela 6
PK - Pakistan 5
AL - Albania 4
CR - Costa Rica 4
KE - Kenya 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BB - Barbados 3
DZ - Algeria 3
EU - Europa 3
JO - Giordania 3
KZ - Kazakistan 3
MN - Mongolia 3
AZ - Azerbaigian 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BO - Bolivia 2
CH - Svizzera 2
GP - Guadalupe 2
GR - Grecia 2
HN - Honduras 2
IM - Isola di Man 2
JM - Giamaica 2
KG - Kirghizistan 2
LB - Libano 2
NP - Nepal 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
ZW - Zimbabwe 2
AO - Angola 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GD - Grenada 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
GY - Guiana 1
HR - Croazia 1
HT - Haiti 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
ME - Montenegro 1
MK - Macedonia 1
ML - Mali 1
Totale 13.007
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Città #
Fairfield 879
Ashburn 617
Chandler 539
Singapore 532
Woodbridge 463
Houston 445
Seattle 359
Hong Kong 354
Nyköping 309
Wilmington 301
Cambridge 290
Beijing 281
Ann Arbor 267
Dallas 186
Jacksonville 181
Bari 177
Munich 136
New York 114
Los Angeles 102
Lawrence 98
Roxbury 98
Montréal 88
Nanjing 85
Brooklyn 68
Mcallen 68
Boardman 59
Des Moines 58
São Paulo 58
Princeton 53
Santa Clara 50
Ho Chi Minh City 45
Dong Ket 44
Buffalo 43
Jakarta 43
Inglewood 40
London 40
Abidjan 38
Moscow 37
San Diego 37
Chicago 30
Dublin 29
Hebei 28
Warsaw 28
Hanoi 26
Turku 26
Tokyo 25
Council Bluffs 24
Falkenstein 22
Helsinki 22
Langenzersdorf 22
Rio de Janeiro 22
Jiaxing 21
Denver 20
Paris 20
Sannicandro di Bari 20
Shenyang 19
The Dalles 19
Brussels 18
Redwood City 18
North Bergen 17
San Francisco 17
Nanchang 16
Rome 16
Falls Church 15
Frankfurt am Main 15
Brasília 14
Changsha 14
Mexico City 14
Montreal 14
Tianjin 14
Vienna 14
Brno 13
Columbus 13
Nuremberg 13
Belo Horizonte 12
Boston 12
Chennai 12
Florence 12
Toronto 12
Dearborn 11
Phoenix 11
Poplar 11
Stockholm 11
Kansas City 10
Shanghai 10
Amsterdam 9
Atlanta 9
Mumbai 9
Wuhan 9
Ardabil 8
Augusta 8
Curitiba 8
Edinburgh 8
Guangzhou 8
Johannesburg 8
Manchester 8
Porto Alegre 8
Pune 8
Tanta 8
Tashkent 8
Totale 8.608
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Nome #
ABC pumps and their role in active drug transport 398
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 197
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 186
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 185
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 185
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 183
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 182
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 177
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 173
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 172
An updated patent review on P-glycoprotein inhibitors (2011-2018) 164
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 164
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 163
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 161
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 159
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 157
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 155
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 150
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 150
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 148
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 148
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 147
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 147
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 147
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 146
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 145
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 145
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 144
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 143
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 138
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 137
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 135
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 134
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 134
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 134
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 132
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 131
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 130
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 128
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 124
An innovative small molecule for promoting neuroreparative strategies 123
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 123
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 121
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 121
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 119
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 119
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 119
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 118
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 116
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 115
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 112
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 112
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 110
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 109
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 109
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 108
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 108
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 107
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 106
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 105
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 105
Is the sigma-2 receptor a histone binding protein? 105
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 104
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 102
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 101
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 100
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 100
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 94
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 90
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 90
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 89
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 87
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 86
Small and innovative molecules as new strategy to revert MDR 85
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 84
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 81
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 80
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 80
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 79
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 78
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 78
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 78
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 77
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 73
SAR study on Arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity 73
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 72
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 71
Mucoadhesive Properties and Interaction with P-glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study 70
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 69
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 69
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 69
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 68
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 68
Why PB28 Could Be a Covid 2019 Game Changer? 68
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 67
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 67
New strategies to overcome resistance to chemotherapy and immune system in cancer 67
null 64
Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain 64
Totale 11.913
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Categoria #
all - tutte 55.608
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 55.608
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021713 0 0 0 0 0 70 108 81 99 142 124 89
2021/2022977 66 100 23 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20262.821 647 286 557 648 612 71 0 0 0 0 0 0
Totale 13.445