IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 6.926
AS - Asia 2.758
EU - Europa 2.677
SA - Sud America 751
AF - Africa 87
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 7
Totale 13.220
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Nazione #
US - Stati Uniti d'America 6.736
SG - Singapore 1.131
CN - Cina 725
BR - Brasile 655
DE - Germania 608
RU - Federazione Russa 456
SE - Svezia 444
IT - Italia 373
HK - Hong Kong 365
GB - Regno Unito 297
VN - Vietnam 225
CA - Canada 138
FI - Finlandia 118
UA - Ucraina 79
FR - Francia 65
IN - India 64
ID - Indonesia 55
AT - Austria 45
AR - Argentina 40
CI - Costa d'Avorio 38
PL - Polonia 36
BD - Bangladesh 30
JP - Giappone 30
IE - Irlanda 29
MX - Messico 28
IQ - Iraq 27
BE - Belgio 22
NL - Olanda 21
EC - Ecuador 18
ES - Italia 18
CZ - Repubblica Ceca 17
EG - Egitto 13
TW - Taiwan 13
ZA - Sudafrica 13
AU - Australia 12
IR - Iran 12
CO - Colombia 10
CL - Cile 9
LT - Lituania 9
RO - Romania 9
AE - Emirati Arabi Uniti 8
TR - Turchia 8
UZ - Uzbekistan 8
KR - Corea 7
MA - Marocco 7
VE - Venezuela 7
DK - Danimarca 6
IL - Israele 6
PK - Pakistan 6
PY - Paraguay 6
SA - Arabia Saudita 6
AL - Albania 4
CR - Costa Rica 4
JO - Giordania 4
KE - Kenya 4
A2 - ???statistics.table.value.countryCode.A2??? 3
AZ - Azerbaigian 3
BB - Barbados 3
DZ - Algeria 3
EU - Europa 3
KG - Kirghizistan 3
KZ - Kazakistan 3
MN - Mongolia 3
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BO - Bolivia 2
CH - Svizzera 2
GD - Grenada 2
GP - Guadalupe 2
GR - Grecia 2
HN - Honduras 2
IM - Isola di Man 2
JM - Giamaica 2
LB - Libano 2
NP - Nepal 2
NZ - Nuova Zelanda 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
TN - Tunisia 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
ZW - Zimbabwe 2
AO - Angola 1
BY - Bielorussia 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
GY - Guiana 1
HR - Croazia 1
HT - Haiti 1
KH - Cambogia 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
ME - Montenegro 1
Totale 13.206
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Città #
Fairfield 879
Ashburn 634
Singapore 571
Chandler 539
Woodbridge 463
Houston 447
Seattle 359
Hong Kong 357
Nyköping 309
Wilmington 301
Cambridge 290
Beijing 281
Ann Arbor 267
Dallas 186
Jacksonville 181
Bari 177
Munich 136
New York 117
Los Angeles 107
Lawrence 98
Roxbury 98
Montréal 88
Nanjing 85
Brooklyn 68
Mcallen 68
Boardman 59
São Paulo 59
Des Moines 58
Ho Chi Minh City 57
Princeton 53
Santa Clara 51
Dong Ket 44
Buffalo 43
Jakarta 43
London 41
Inglewood 40
Abidjan 38
Hanoi 38
Moscow 37
San Diego 37
Chicago 31
Dublin 29
Warsaw 29
Hebei 28
Tokyo 26
Turku 26
Council Bluffs 24
Denver 23
Falkenstein 22
Helsinki 22
Langenzersdorf 22
Rio de Janeiro 22
Jiaxing 21
Paris 21
Sannicandro di Bari 20
Shenyang 19
The Dalles 19
Brussels 18
Redwood City 18
North Bergen 17
San Francisco 17
Montreal 16
Nanchang 16
Rome 16
Falls Church 15
Frankfurt am Main 15
Stockholm 15
Brasília 14
Changsha 14
Mexico City 14
Tianjin 14
Vienna 14
Brno 13
Columbus 13
Nuremberg 13
Orem 13
Belo Horizonte 12
Boston 12
Chennai 12
Florence 12
Poplar 12
Toronto 12
Dearborn 11
Phoenix 11
Amsterdam 10
Atlanta 10
Kansas City 10
Manchester 10
San Jose 10
Shanghai 10
Augusta 9
Johannesburg 9
Mumbai 9
Wuhan 9
Ardabil 8
Curitiba 8
Da Nang 8
Edinburgh 8
Guangzhou 8
Porto Alegre 8
Totale 8.731
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Nome #
ABC pumps and their role in active drug transport 400
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 199
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 188
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 188
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 186
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 186
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 184
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 179
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 175
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 174
An updated patent review on P-glycoprotein inhibitors (2011-2018) 166
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 166
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 165
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 163
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 161
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 158
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 157
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 154
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 151
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 150
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 150
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 149
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 149
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 148
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 147
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 147
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 146
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 146
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 145
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 140
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 139
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 136
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 136
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 136
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 135
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 133
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 133
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 131
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 129
An innovative small molecule for promoting neuroreparative strategies 125
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 125
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 124
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 122
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 122
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 121
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 120
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 119
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 119
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 118
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 117
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 115
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 112
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 112
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 112
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 110
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 110
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 109
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 108
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 107
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 106
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 106
Is the sigma-2 receptor a histone binding protein? 106
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 105
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 103
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 103
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 102
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 101
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 96
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 93
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 90
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 90
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 89
Small and innovative molecules as new strategy to revert MDR 87
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 87
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 85
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 84
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 82
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 81
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 81
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 80
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 80
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 79
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 78
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 74
SAR study on Arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity 74
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 74
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 72
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 72
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 70
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 70
Mucoadhesive Properties and Interaction with P-glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study 70
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 70
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 69
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 69
Why PB28 Could Be a Covid 2019 Game Changer? 69
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 68
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 67
New strategies to overcome resistance to chemotherapy and immune system in cancer 67
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 65
Totale 12.069
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Categoria #
all - tutte 56.287
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.287
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021713 0 0 0 0 0 70 108 81 99 142 124 89
2021/2022977 66 100 23 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20263.020 647 286 557 648 612 270 0 0 0 0 0 0
Totale 13.644