IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 7.644
AS - Asia 3.407
EU - Europa 3.015
SA - Sud America 900
AF - Africa 134
OC - Oceania 18
Continente sconosciuto - Info sul continente non disponibili 7
Totale 15.125
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Nazione #
US - Stati Uniti d'America 7.421
SG - Singapore 1.364
CN - Cina 798
BR - Brasile 738
DE - Germania 644
RU - Federazione Russa 463
IT - Italia 457
SE - Svezia 445
HK - Hong Kong 394
GB - Regno Unito 309
VN - Vietnam 268
FR - Francia 184
CA - Canada 151
FI - Finlandia 149
IN - India 105
UA - Ucraina 84
ID - Indonesia 73
BD - Bangladesh 64
AR - Argentina 63
IQ - Iraq 53
AT - Austria 45
JP - Giappone 45
PL - Polonia 40
CI - Costa d'Avorio 39
MX - Messico 39
PK - Pakistan 32
IE - Irlanda 30
NL - Olanda 30
CO - Colombia 26
BE - Belgio 25
ES - Italia 25
ZA - Sudafrica 25
EC - Ecuador 24
TR - Turchia 22
EG - Egitto 21
SA - Arabia Saudita 20
TW - Taiwan 20
UZ - Uzbekistan 20
CZ - Repubblica Ceca 19
VE - Venezuela 16
AU - Australia 15
CL - Cile 14
MA - Marocco 14
MY - Malesia 14
PH - Filippine 13
IR - Iran 12
AE - Emirati Arabi Uniti 11
KR - Corea 10
JO - Giordania 9
LT - Lituania 9
RO - Romania 9
CR - Costa Rica 8
BO - Bolivia 7
PY - Paraguay 7
TN - Tunisia 7
AZ - Azerbaigian 6
DK - Danimarca 6
DZ - Algeria 6
IL - Israele 6
KE - Kenya 6
KG - Kirghizistan 6
PS - Palestinian Territory 6
SK - Slovacchia (Repubblica Slovacca) 6
ET - Etiopia 5
KZ - Kazakistan 5
OM - Oman 5
AL - Albania 4
CH - Svizzera 4
LB - Libano 4
MN - Mongolia 4
NP - Nepal 4
TH - Thailandia 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BB - Barbados 3
BG - Bulgaria 3
EU - Europa 3
GT - Guatemala 3
HU - Ungheria 3
JM - Giamaica 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
ZW - Zimbabwe 3
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
BY - Bielorussia 2
GD - Grenada 2
GE - Georgia 2
GP - Guadalupe 2
GR - Grecia 2
HN - Honduras 2
IM - Isola di Man 2
MD - Moldavia 2
PE - Perù 2
SY - Repubblica araba siriana 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
AM - Armenia 1
AO - Angola 1
BJ - Benin 1
BS - Bahamas 1
Totale 15.098
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Città #
Fairfield 879
Singapore 725
Ashburn 706
Chandler 539
Woodbridge 463
Houston 447
Hong Kong 379
San Jose 369
Seattle 360
Nyköping 309
Wilmington 301
Cambridge 290
Beijing 289
Ann Arbor 267
Dallas 191
Jacksonville 181
Bari 180
Munich 136
New York 124
Lauterbourg 121
Los Angeles 117
Lawrence 98
Roxbury 98
Montréal 88
Nanjing 85
São Paulo 71
Brooklyn 68
Mcallen 68
Ho Chi Minh City 65
Council Bluffs 61
Santa Clara 61
Boardman 60
Des Moines 59
Helsinki 53
Princeton 53
Falkenstein 47
Jakarta 47
Buffalo 46
Hanoi 45
Dong Ket 44
London 42
San Diego 41
Inglewood 40
Abidjan 39
Moscow 39
Tokyo 39
Chicago 35
Dublin 30
Warsaw 30
Hebei 28
Turku 26
Denver 25
Rio de Janeiro 25
Frankfurt am Main 24
Langenzersdorf 22
Orem 22
Paris 22
Jiaxing 21
Sannicandro di Bari 20
Shenyang 20
Brussels 19
Rome 19
Tashkent 19
The Dalles 19
Montreal 18
Redwood City 18
San Francisco 18
North Bergen 17
Toronto 17
Amsterdam 16
Baghdad 16
Nanchang 16
Stockholm 16
Belo Horizonte 15
Brasília 15
Falls Church 15
Mexico City 15
Changsha 14
Salt Lake City 14
Tianjin 14
Vienna 14
Boston 13
Brno 13
Chennai 13
Columbus 13
Nuremberg 13
Atlanta 12
Florence 12
Poplar 12
Curitiba 11
Da Nang 11
Dearborn 11
Dhaka 11
Johannesburg 11
Lahore 11
Manchester 11
Mumbai 11
Phoenix 11
Kansas City 10
Shanghai 10
Totale 9.744
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Nome #
ABC pumps and their role in active drug transport 411
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 214
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 210
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 207
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 204
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 202
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 201
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 196
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 191
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
An updated patent review on P-glycoprotein inhibitors (2011-2018) 181
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 180
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 180
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 178
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 176
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 176
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 172
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 170
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 168
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 162
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 162
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 161
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 161
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 161
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 160
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 159
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 158
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 157
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 154
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 152
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 150
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 150
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 148
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 148
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 147
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 144
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 143
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 143
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 142
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 139
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 138
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
An innovative small molecule for promoting neuroreparative strategies 137
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 136
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 134
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 134
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 133
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 132
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 131
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 130
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 126
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 124
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 120
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 118
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 117
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 116
Is the sigma-2 receptor a histone binding protein? 116
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 116
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 114
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 113
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 113
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 112
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 111
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 111
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 111
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 109
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 109
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 109
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 107
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 104
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 104
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 103
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 103
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 102
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 102
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 101
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 99
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 99
Small and innovative molecules as new strategy to revert MDR 97
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 95
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 93
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 90
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 89
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 89
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 87
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 87
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 86
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 85
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 84
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 83
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 81
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 80
SAR study on Arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity 80
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 80
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 79
Why PB28 Could Be a Covid 2019 Game Changer? 78
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 77
Totale 13.506
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Categoria #
all - tutte 59.986
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.986
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021355 0 0 0 0 0 0 0 0 0 142 124 89
2021/2022977 66 100 23 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20264.928 647 286 557 648 612 342 620 174 549 493 0 0
Totale 15.552