IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 7.921
AS - Asia 3.484
EU - Europa 3.070
SA - Sud America 902
AF - Africa 134
OC - Oceania 18
Continente sconosciuto - Info sul continente non disponibili 7
Totale 15.536
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Nazione #
US - Stati Uniti d'America 7.687
SG - Singapore 1.382
CN - Cina 811
BR - Brasile 739
DE - Germania 644
IT - Italia 505
RU - Federazione Russa 463
SE - Svezia 445
HK - Hong Kong 402
GB - Regno Unito 310
VN - Vietnam 269
FR - Francia 184
CA - Canada 159
FI - Finlandia 149
IN - India 105
BD - Bangladesh 97
UA - Ucraina 84
ID - Indonesia 73
AR - Argentina 63
IQ - Iraq 53
AT - Austria 45
JP - Giappone 45
MX - Messico 40
PL - Polonia 40
CI - Costa d'Avorio 39
NL - Olanda 33
PK - Pakistan 32
IE - Irlanda 30
CO - Colombia 27
BE - Belgio 25
ES - Italia 25
ZA - Sudafrica 25
EC - Ecuador 24
TR - Turchia 22
EG - Egitto 21
SA - Arabia Saudita 20
TW - Taiwan 20
UZ - Uzbekistan 20
CZ - Repubblica Ceca 19
VE - Venezuela 16
AU - Australia 15
CL - Cile 14
MA - Marocco 14
MY - Malesia 14
PH - Filippine 13
IR - Iran 12
AE - Emirati Arabi Uniti 11
KR - Corea 10
JO - Giordania 9
LT - Lituania 9
RO - Romania 9
CR - Costa Rica 8
AZ - Azerbaigian 7
BO - Bolivia 7
CH - Svizzera 7
PY - Paraguay 7
TN - Tunisia 7
DK - Danimarca 6
DZ - Algeria 6
IL - Israele 6
KE - Kenya 6
KG - Kirghizistan 6
PS - Palestinian Territory 6
SK - Slovacchia (Repubblica Slovacca) 6
ET - Etiopia 5
KZ - Kazakistan 5
OM - Oman 5
SY - Repubblica araba siriana 5
AL - Albania 4
GT - Guatemala 4
LB - Libano 4
MN - Mongolia 4
NP - Nepal 4
TH - Thailandia 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BB - Barbados 3
BG - Bulgaria 3
EU - Europa 3
HU - Ungheria 3
JM - Giamaica 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
TT - Trinidad e Tobago 3
ZW - Zimbabwe 3
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
BY - Bielorussia 2
GD - Grenada 2
GE - Georgia 2
GP - Guadalupe 2
GR - Grecia 2
HN - Honduras 2
IM - Isola di Man 2
MD - Moldavia 2
PE - Perù 2
UY - Uruguay 2
AM - Armenia 1
AO - Angola 1
BJ - Benin 1
BS - Bahamas 1
Totale 15.509
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Città #
Fairfield 879
Singapore 736
Ashburn 722
Chandler 539
Woodbridge 463
Houston 448
San Jose 430
Hong Kong 387
Seattle 361
Nyköping 309
Wilmington 301
Beijing 295
Cambridge 290
Ann Arbor 267
Dallas 193
Bari 185
Jacksonville 184
New York 142
Munich 136
Lauterbourg 121
Los Angeles 121
Lawrence 98
Roxbury 98
Montréal 88
Boardman 86
Nanjing 85
Brooklyn 71
São Paulo 71
Mcallen 68
Santa Clara 68
Ho Chi Minh City 66
Council Bluffs 62
Des Moines 59
Helsinki 53
Princeton 53
Buffalo 49
Falkenstein 47
Jakarta 47
Hanoi 45
Dong Ket 44
London 43
San Diego 41
Inglewood 40
Abidjan 39
Moscow 39
Tokyo 39
Chicago 35
Dublin 30
Warsaw 30
Hebei 28
Denver 27
Turku 26
Rio de Janeiro 25
Frankfurt am Main 24
Rome 23
Langenzersdorf 22
Orem 22
Paris 22
The Dalles 22
Jiaxing 21
Montreal 20
Sannicandro di Bari 20
Shenyang 20
Brussels 19
Tashkent 19
Toronto 19
Redwood City 18
San Francisco 18
North Bergen 17
Amsterdam 16
Baghdad 16
Mexico City 16
Nanchang 16
Phoenix 16
Stockholm 16
Atlanta 15
Belo Horizonte 15
Brasília 15
Falls Church 15
Tianjin 15
Boston 14
Changsha 14
Milan 14
Salt Lake City 14
Vienna 14
Brno 13
Chennai 13
Columbus 13
Nuremberg 13
Dhaka 12
Florence 12
Poplar 12
Curitiba 11
Da Nang 11
Dearborn 11
Johannesburg 11
Lahore 11
Manchester 11
Mumbai 11
Augusta 10
Totale 9.951
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Nome #
ABC pumps and their role in active drug transport 411
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 229
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 220
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 218
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 211
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 207
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 204
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 200
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 194
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 184
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 184
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 182
An updated patent review on P-glycoprotein inhibitors (2011-2018) 182
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 180
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 178
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 177
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 172
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 172
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 171
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 164
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 164
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 163
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 163
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 162
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 162
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 161
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 161
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 158
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 155
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 155
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 155
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 153
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 152
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 151
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 149
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 146
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 146
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 146
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 144
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 144
An innovative small molecule for promoting neuroreparative strategies 141
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 141
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 138
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 137
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 137
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 135
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 134
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 134
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 133
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 131
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 127
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 122
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 121
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 120
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 119
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 119
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 118
Is the sigma-2 receptor a histone binding protein? 118
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 117
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 116
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 116
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 115
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 115
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 114
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 113
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 112
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 111
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 110
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 109
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 108
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 108
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 107
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 106
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 104
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 104
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 103
Small and innovative molecules as new strategy to revert MDR 103
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 102
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 98
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 96
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 93
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 92
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 90
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 90
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 89
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 87
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 86
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 86
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 85
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 85
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 84
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 83
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 82
SAR study on Arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity 82
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 81
DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues 79
Totale 13.821
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Categoria #
all - tutte 63.185
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.185
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202189 0 0 0 0 0 0 0 0 0 0 0 89
2021/2022977 66 100 23 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20265.341 647 286 557 648 612 342 620 174 549 567 197 142
Totale 15.965