IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 5.425
EU - Europa 1.670
AS - Asia 426
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 6
SA - Sud America 6
AF - Africa 1
Totale 7.546
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Nazione #
US - Stati Uniti d'America 5.331
DE - Germania 459
SE - Svezia 427
CN - Cina 323
IT - Italia 235
GB - Regno Unito 217
CA - Canada 93
FI - Finlandia 83
RU - Federazione Russa 82
UA - Ucraina 70
VN - Vietnam 45
FR - Francia 28
IE - Irlanda 25
IN - India 24
BE - Belgio 19
AU - Australia 10
IR - Iran 10
RO - Romania 7
ID - Indonesia 5
NL - Olanda 5
A2 - ???statistics.table.value.countryCode.A2??? 3
AT - Austria 3
EU - Europa 3
HK - Hong Kong 3
JP - Giappone 3
BR - Brasile 2
CL - Cile 2
ES - Italia 2
MN - Mongolia 2
NZ - Nuova Zelanda 2
PL - Polonia 2
SG - Singapore 2
TH - Thailandia 2
TR - Turchia 2
AR - Argentina 1
DK - Danimarca 1
GE - Georgia 1
IM - Isola di Man 1
KR - Corea 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
MX - Messico 1
PE - Perù 1
PK - Pakistan 1
PT - Portogallo 1
SK - Slovacchia (Repubblica Slovacca) 1
ZW - Zimbabwe 1
Totale 7.546
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Città #
Fairfield 879
Chandler 539
Woodbridge 463
Houston 426
Seattle 354
Ashburn 346
Nyköping 309
Wilmington 297
Cambridge 290
Ann Arbor 266
Jacksonville 174
Bari 145
Beijing 106
Lawrence 96
Roxbury 96
Montréal 88
Nanjing 84
New York 80
Mcallen 68
Munich 62
Des Moines 56
Princeton 53
Brooklyn 48
Dong Ket 44
Inglewood 40
San Diego 36
Boardman 30
Hebei 27
Dublin 25
Sannicandro di Bari 21
London 18
Redwood City 18
Brussels 17
Jiaxing 17
Shenyang 17
Nanchang 16
Paris 16
Falls Church 15
Helsinki 13
Changsha 12
Tianjin 12
Dearborn 11
Kansas City 10
Ardabil 8
Pune 8
Edinburgh 7
Los Angeles 7
Marseille 7
Norwalk 7
Augusta 6
Leawood 6
Boydton 5
Hefei 5
Hounslow 5
Jinan 5
Ningbo 5
San Francisco 5
San Mateo 5
Chiswick 4
Indiana 4
Monmouth Junction 4
Rome 4
Sydney 4
Washington 4
Acquaviva delle Fonti 3
Detroit 3
Guangzhou 3
Kilburn 3
Noci 3
Triggiano 3
Vienna 3
Auckland 2
Bangkok 2
Baotou 2
Bergamo 2
Boston 2
Canberra 2
Central 2
Chengdu 2
Groningen 2
Kunming 2
Kursk 2
Liège 2
Melbourne 2
Mola Di Bari 2
Napoli 2
Prescot 2
San Giovanni Rotondo 2
San Jose 2
Tappahannock 2
Toronto 2
Ulan Bator 2
Acton 1
Alexandria 1
Alghero 1
Amsterdam 1
Atlanta 1
Barcellona Pozzo di Gotto 1
Biella 1
Bitonto 1
Totale 5.926
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Nome #
ABC pumps and their role in active drug transport 355
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 146
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 146
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 139
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 130
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 127
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 123
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 121
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 120
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 119
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 114
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 114
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 109
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 109
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 104
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 103
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 101
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 101
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 98
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 98
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 96
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 95
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 95
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 94
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 93
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 93
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 93
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 92
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 92
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 91
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 91
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 89
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 89
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 88
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 88
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 88
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 84
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 84
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 83
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 83
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 82
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 82
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 80
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 79
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 79
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 79
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 79
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 79
An updated patent review on P-glycoprotein inhibitors (2011-2018) 79
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 78
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 78
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 77
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 77
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 76
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 76
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 72
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 71
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 71
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 70
Is the sigma-2 receptor a histone binding protein? 69
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 69
An innovative small molecule for promoting neuroreparative strategies 66
null 64
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 63
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 63
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 63
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 63
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 58
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 57
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 54
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 54
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 53
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 53
Mucoadhesive Properties and Interaction with P-glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study 52
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 52
null 46
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 43
Small and innovative molecules as new strategy to revert MDR 43
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 42
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 42
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 40
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 40
Receptor drug interaction: europium employment for studying the biochemical pathway of GPRC activation 39
New strategies to overcome resistance to chemotherapy and immune system in cancer 39
Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain 39
null 38
Why PB28 Could Be a Covid 2019 Game Changer? 37
Evaluation of sigma2 receptor expression in human invasive bladder cancer 36
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 33
Novel potent and selective θ ligands: Evaluation of their agonist and antagonist properties 31
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 31
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 29
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2 28
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 27
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 25
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 20
Potential positron emission tomography radioligand for brain dopamine D3 receptor visualization: design, synthesis, binding profile, and interaction with the efflux pump P-glycoprtein. 19
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 18
SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity on P-gp protein. 17
Totale 7.669
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Categoria #
all - tutte 29.415
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.415
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019617 0 0 0 0 0 0 0 0 0 115 264 238
2019/20202.189 292 83 66 186 191 130 205 215 262 210 204 145
2020/20211.173 86 111 98 83 87 70 107 81 98 141 123 88
2021/2022968 66 99 23 30 64 91 52 45 76 85 136 201
2022/20231.422 204 185 106 99 196 157 16 168 224 9 37 21
2023/2024430 45 90 29 51 41 108 25 17 11 13 0 0
Totale 7.832