IRIS
CONTINO, MARIALESSANDRA
 Distribuzione geografica
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Continente #
NA - Nord America 9.614
EU - Europa 3.747
AS - Asia 3.547
SA - Sud America 933
Continente sconosciuto - Info sul continente non disponibili 451
AF - Africa 146
OC - Oceania 19
Totale 18.457
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Nazione #
US - Stati Uniti d'America 9.238
SG - Singapore 1.388
IT - Italia 1.137
CN - Cina 820
BR - Brasile 756
DE - Germania 646
RU - Federazione Russa 475
SE - Svezia 445
HK - Hong Kong 407
GB - Regno Unito 320
VN - Vietnam 269
CA - Canada 213
FR - Francia 186
FI - Finlandia 149
BD - Bangladesh 121
IN - India 105
UA - Ucraina 84
ID - Indonesia 75
AR - Argentina 65
IQ - Iraq 53
AT - Austria 46
JP - Giappone 45
MX - Messico 42
PL - Polonia 40
CI - Costa d'Avorio 39
NL - Olanda 36
PK - Pakistan 33
CO - Colombia 32
EC - Ecuador 30
IE - Irlanda 30
ES - Italia 28
BE - Belgio 25
ZA - Sudafrica 25
TR - Turchia 22
EG - Egitto 21
SA - Arabia Saudita 21
TW - Taiwan 20
UZ - Uzbekistan 20
CR - Costa Rica 19
CZ - Repubblica Ceca 19
VE - Venezuela 17
AU - Australia 16
MY - Malesia 16
PH - Filippine 16
SV - El Salvador 16
GT - Guatemala 15
CL - Cile 14
MA - Marocco 14
HN - Honduras 13
TT - Trinidad e Tobago 13
IR - Iran 12
LT - Lituania 12
AE - Emirati Arabi Uniti 11
CW - ???statistics.table.value.countryCode.CW??? 11
DK - Danimarca 11
IL - Israele 11
SC - Seychelles 11
KR - Corea 10
JO - Giordania 9
RO - Romania 9
GP - Guadalupe 8
PR - Porto Rico 8
AZ - Azerbaigian 7
BO - Bolivia 7
CH - Svizzera 7
JM - Giamaica 7
NI - Nicaragua 7
PY - Paraguay 7
TH - Thailandia 7
TN - Tunisia 7
DZ - Algeria 6
KE - Kenya 6
KG - Kirghizistan 6
KZ - Kazakistan 6
PS - Palestinian Territory 6
SK - Slovacchia (Repubblica Slovacca) 6
ET - Etiopia 5
OM - Oman 5
SY - Repubblica araba siriana 5
AL - Albania 4
LB - Libano 4
MN - Mongolia 4
NP - Nepal 4
A2 - ???statistics.table.value.countryCode.A2??? 3
BB - Barbados 3
BG - Bulgaria 3
BS - Bahamas 3
EE - Estonia 3
EU - Europa 3
HU - Ungheria 3
LV - Lettonia 3
NZ - Nuova Zelanda 3
ZW - Zimbabwe 3
BA - Bosnia-Erzegovina 2
BH - Bahrain 2
BY - Bielorussia 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
IM - Isola di Man 2
Totale 17.985
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Città #
Fairfield 880
Ashburn 852
Singapore 739
San Jose 624
Los Angeles 541
Chandler 539
Woodbridge 463
Houston 451
Hong Kong 392
Seattle 362
Milan 328
Nyköping 309
Wilmington 302
Beijing 301
Cambridge 290
Ann Arbor 267
Council Bluffs 226
Dallas 204
Bari 193
Jacksonville 186
New York 156
Munich 136
Lauterbourg 121
Rome 115
Lawrence 98
Roxbury 98
Boardman 96
Santa Clara 94
Montréal 88
Nanjing 85
São Paulo 81
Brooklyn 79
Mcallen 68
Ho Chi Minh City 66
Des Moines 59
Columbus 58
Chicago 57
Buffalo 53
Helsinki 53
Princeton 53
Falkenstein 47
Jakarta 47
Hanoi 45
Dong Ket 44
London 44
San Diego 42
Inglewood 40
Phoenix 40
Abidjan 39
Moscow 39
Tokyo 39
Dublin 30
Toronto 30
Turin 30
Warsaw 30
Figino 29
North Bergen 29
Denver 28
Hebei 28
Naples 26
Turku 26
Frankfurt am Main 25
Rio de Janeiro 25
Atlanta 24
Montreal 24
The Dalles 24
Orem 23
Langenzersdorf 22
Paris 22
Jiaxing 21
San Francisco 20
Sannicandro di Bari 20
Shenyang 20
Brussels 19
Florence 19
Tashkent 19
Redwood City 18
Washington 18
Amsterdam 16
Baghdad 16
Boston 16
Mexico City 16
Nanchang 16
San José 16
Stockholm 16
Belo Horizonte 15
Brasília 15
Falls Church 15
Philadelphia 15
Tianjin 15
Vienna 15
Changsha 14
Salt Lake City 14
Brno 13
Chennai 13
Columbia 13
Guatemala City 13
Nuremberg 13
San Salvador 13
Bologna 12
Totale 11.598
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Nome #
ABC pumps and their role in active drug transport 422
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 260
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 240
miRNAs for the Detection of MultiDrug Resistance: Overview and Perspectives 238
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 235
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 233
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 231
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 226
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 220
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 220
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells. 219
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 218
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 215
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 207
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 205
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 199
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 196
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 196
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 194
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 192
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 190
An updated patent review on P-glycoprotein inhibitors (2011-2018) 189
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 189
Is the sigma-2 receptor a histone binding protein? 188
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 188
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 187
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 187
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 183
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 182
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 181
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders 179
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators 179
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 176
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation 174
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 174
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 169
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 169
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 168
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 168
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers 166
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands 164
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 163
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity 160
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein 159
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 158
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 158
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 157
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 155
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 155
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 153
An innovative small molecule for promoting neuroreparative strategies 153
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 153
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 151
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 149
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 146
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 145
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers 143
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death 143
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 140
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 139
DECONSTRUCTING ONC201 TO DESIGN NEW MITOCHONDRIAL ClpP ACTIVATORS FOR PEDIATRIC H3K27-ALTERED DIFFUSE MIDLINE GLIOMA 139
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes 138
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 134
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 134
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 133
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 128
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers. 128
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 127
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 125
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 124
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 124
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression 124
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 124
DeLA-DrugSelf: Empowering multi-objective de novo design through SELFIES molecular representation 123
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 123
Induced expression of P-gp and BCRP transporters on brain endothelial cells using transferrin functionalized nanostructured lipid carriers: A first step of a potential strategy for the treatment of Alzheimer's disease 123
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 121
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation 121
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 120
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 113
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 113
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis 113
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 111
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells 111
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma 110
Small and innovative molecules as new strategy to revert MDR 108
Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment 106
THE INTERACTION OF CELECOXIB WITH MDR TRANSPORTERS ENHANCES THE ACTIVITY OF MITOMYCIN C IN A BLADDER CANCER CELL LINE 106
Novel tetrahydroisoquinoline compounds for use in the diagnosis and treatment of neurodegenerative diseases 105
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 104
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 102
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 100
Sigma-2 receptors as potential novel biomarkers during the progression of benign prostatic hypertrophy (BPH) into prostate cancer 100
DeLA-Drug: A Deep Learning Algorithm for Automated Design of Druglike Analogues 100
ABC transporters in CSCs membrans as a novel target for treating tumor relapse 99
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 98
One molecule two goals: A selective P-glycoprotein modulator increases drug transport across gastro-intestinal barrier and recovers doxorubicin toxicity in multidrug resistant cancer cells 98
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 97
ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators 96
Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs 94
Totale 15.793
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Categoria #
all - tutte 70.566
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 70.566
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022788 0 0 0 32 64 91 52 47 76 85 138 203
2022/20231.432 206 185 106 98 197 159 17 169 228 9 37 21
2023/2024528 46 90 28 50 42 108 25 15 10 13 14 87
2024/20252.640 120 25 182 115 89 220 338 214 132 152 354 699
2025/20265.855 647 286 557 648 612 342 620 174 549 567 197 656
2026/20271.978 581 302 369 726 0 0 0 0 0 0 0 0
Totale 18.457