A potent sigma-2 receptor ligand, known as PB28, was tritium radiolabelled and biologically evaluated. The results showed that [3H]PB28 and the corresponding unlabelled PB28 had superimposed pharmacodynamic properties. This radioligand appears as a potential candidate for receptor binding and in living cells assays.
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization
COLABUFO, Nicola Antonio;ABATE, CARMEN rosa;CONTINO, MARIALESSANDRA;FERORELLI, Savina;BERARDI, Francesco;PERRONE, Roberto
2008-01-01
Abstract
A potent sigma-2 receptor ligand, known as PB28, was tritium radiolabelled and biologically evaluated. The results showed that [3H]PB28 and the corresponding unlabelled PB28 had superimposed pharmacodynamic properties. This radioligand appears as a potential candidate for receptor binding and in living cells assays.File in questo prodotto:
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