| Nome |
# |
|
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders, file d5e825ac-71b9-4343-ab1b-ba913fddc5b7
|
132
|
|
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies, file 400270d7-9caf-491c-9c10-1978d408721f
|
100
|
|
Editorial: The CB2 cannabinoid system: A new strategy in neurodegenerative disorder and neuroinflammation, file dd9e0c64-37c1-1e9c-e053-3a05fe0a45ef
|
74
|
|
Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death, file dd9e0c67-b0b7-1e9c-e053-3a05fe0a45ef
|
71
|
|
Sugar-based bactericides targeting phosphatidylethanolamine-enriched membranes, file dd9e0c67-4044-1e9c-e053-3a05fe0a45ef
|
68
|
|
Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain, file dd9e0c67-212e-1e9c-e053-3a05fe0a45ef
|
65
|
|
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine, file dd9e0c64-ff31-1e9c-e053-3a05fe0a45ef
|
60
|
|
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators, file 584005b4-55e0-4b5d-b957-970cde0dcd02
|
44
|
|
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Ab1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells, file dd9e0c67-243c-1e9c-e053-3a05fe0a45ef
|
43
|
|
New strategies to overcome resistance to chemotherapy and immune system in cancer, file dd9e0c67-29a8-1e9c-e053-3a05fe0a45ef
|
43
|
|
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor, file dd9e0c68-0810-1e9c-e053-3a05fe0a45ef
|
43
|
|
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs), file 37494e63-2d5a-4549-afb0-ed673e59bd2b
|
41
|
|
6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers, file dd9e0c66-c0e4-1e9c-e053-3a05fe0a45ef
|
39
|
|
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells., file a55cd1af-f730-4c06-ae4c-3471ef84cc01
|
23
|
|
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents, file dd9e0c63-a7e0-1e9c-e053-3a05fe0a45ef
|
12
|
|
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors, file cccea57e-b25a-4891-b57c-3c93e0d8331c
|
9
|
|
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c6c-84df-1e9c-e053-3a05fe0a45ef
|
9
|
|
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules, file dd9e0c62-f60d-1e9c-e053-3a05fe0a45ef
|
8
|
|
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators, file dd9e0c65-b10e-1e9c-e053-3a05fe0a45ef
|
6
|
|
Structure-Activity Relationship Studies on Tetrahydroisoquinoline Derivatives: [4′-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylmethyl)biphenyl-4-ol] (MC70) Conjugated through Flexible Alkyl Chains with Furazan Moieties Gives Rise to Potent and Selective Ligands of P-glycoprotein, file dd9e0c67-3682-1e9c-e053-3a05fe0a45ef
|
6
|
|
Patient Bone Marrow Aspiration to Explore the Cyclooxygenases (COXs) Involvement in Multiple Myeloma, file 2b2f1cf8-c4d5-4197-aea1-f3c24125d19a
|
5
|
|
Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity, file dd9e0c63-c566-1e9c-e053-3a05fe0a45ef
|
4
|
|
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies, file dd9e0c64-baf6-1e9c-e053-3a05fe0a45ef
|
4
|
|
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors, file dd9e0c64-d022-1e9c-e053-3a05fe0a45ef
|
4
|
|
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c63-b970-1e9c-e053-3a05fe0a45ef
|
3
|
|
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump, file dd9e0c64-0e08-1e9c-e053-3a05fe0a45ef
|
3
|
|
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line, file dd9e0c64-8896-1e9c-e053-3a05fe0a45ef
|
3
|
|
The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders, file dd9e0c64-fbc8-1e9c-e053-3a05fe0a45ef
|
3
|
|
An innovative small molecule for promoting neuroreparative strategies, file dd9e0c66-d1cc-1e9c-e053-3a05fe0a45ef
|
3
|
|
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs), file dd9e0c66-d30c-1e9c-e053-3a05fe0a45ef
|
3
|
|
Design, Biological Evaluation and Molecular Modelling of Tetrahydroisoquinoline Derivatives: Discovery of A Potent P-glycoprotein Ligand Overcoming Multi-Drug Resistance in Cancer Stem Cells., file dd9e0c67-212b-1e9c-e053-3a05fe0a45ef
|
3
|
|
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives, file dd9e0c6b-bf0d-1e9c-e053-3a05fe0a45ef
|
3
|
|
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents, file dd9e0c62-7e42-1e9c-e053-3a05fe0a45ef
|
2
|
|
An updated patent review on P-glycoprotein inhibitors (2011-2018), file dd9e0c66-d4d0-1e9c-e053-3a05fe0a45ef
|
2
|
|
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R), file dd9e0c67-09fb-1e9c-e053-3a05fe0a45ef
|
2
|
|
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands, file dd9e0c67-2610-1e9c-e053-3a05fe0a45ef
|
2
|
|
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques, file 65209057-2ca9-4129-bbcc-f6a7e1a12114
|
1
|
|
The multiple combination of Paclitaxel, Ramucirumab and Elacridar reverses the paclitaxel mediated resistance in gastric cancer cell lines, file bc9080ce-0f91-4ef8-be1e-0e01f70680c0
|
1
|
|
null, file dd9e0c63-b973-1e9c-e053-3a05fe0a45ef
|
1
|
|
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes, file dd9e0c63-b9ae-1e9c-e053-3a05fe0a45ef
|
1
|
|
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters, file dd9e0c63-bb1c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors, file dd9e0c63-cba2-1e9c-e053-3a05fe0a45ef
|
1
|
|
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity, file dd9e0c64-45ef-1e9c-e053-3a05fe0a45ef
|
1
|
|
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease, file dd9e0c64-f386-1e9c-e053-3a05fe0a45ef
|
1
|
|
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments, file dd9e0c64-f389-1e9c-e053-3a05fe0a45ef
|
1
|
|
null, file dd9e0c64-f85c-1e9c-e053-3a05fe0a45ef
|
1
|
|
miRNAs for the Detection of MultiDrug Resistance: Overview
and Perspectives, file dd9e0c64-fa24-1e9c-e053-3a05fe0a45ef
|
1
|
|
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo., file dd9e0c64-fce3-1e9c-e053-3a05fe0a45ef
|
1
|
|
Is the sigma-2 receptor a histone binding protein?, file dd9e0c65-ed40-1e9c-e053-3a05fe0a45ef
|
1
|
|
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers, file dd9e0c66-6c8c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Structure-Activity Relationship Studies on 6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Multidrug Resistance Reversers., file dd9e0c66-d386-1e9c-e053-3a05fe0a45ef
|
1
|
|
New tetrahydroisoquinoline-based P-glycoprotein modulators: Decoration of the biphenyl core gives selective ligands, file dd9e0c66-e384-1e9c-e053-3a05fe0a45ef
|
1
|
|
Assessing the Optimal Deoxygenation Pattern of Dodecyl Glycosides for Antimicrobial Activity Against Bacillus anthracis, file dd9e0c67-273e-1e9c-e053-3a05fe0a45ef
|
1
|
|
A Potent and Selective P-gp Modulator for Altering Multidrug Resistance Due to Pump Overexpression, file dd9e0c67-385f-1e9c-e053-3a05fe0a45ef
|
1
|
|
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration, file dd9e0c68-c44a-1e9c-e053-3a05fe0a45ef
|
1
|
|
Small and innovative molecules as new strategy to revert MDR, file dd9e0c6a-86e4-1e9c-e053-3a05fe0a45ef
|
1
|
|
Preclinical comparison study between [ 18 F]fluoromethyl-PBR28 and its deuterated analog in a rat model of neuroinflammation, file dd9e0c6a-89fc-1e9c-e053-3a05fe0a45ef
|
1
|
|
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect, file dd9e0c6c-0700-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
967 |