IRIS
SCILIMATI, Antonio
 Distribuzione geografica
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Continente #
NA - Nord America 9.351
EU - Europa 2.750
AS - Asia 1.513
SA - Sud America 28
OC - Oceania 13
AF - Africa 8
Continente sconosciuto - Info sul continente non disponibili 4
Totale 13.667
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Nazione #
US - Stati Uniti d'America 9.324
CN - Cina 936
IT - Italia 702
SE - Svezia 690
UA - Ucraina 410
DE - Germania 369
SG - Singapore 359
FI - Finlandia 225
GB - Regno Unito 151
ID - Indonesia 65
IN - India 50
VN - Vietnam 44
BE - Belgio 42
FR - Francia 42
RU - Federazione Russa 38
CA - Canada 26
IE - Irlanda 26
JP - Giappone 19
IR - Iran 18
CZ - Repubblica Ceca 16
CL - Cile 15
AU - Australia 11
NL - Olanda 8
EG - Egitto 7
KR - Corea 7
PL - Polonia 7
AT - Austria 4
BR - Brasile 4
EU - Europa 4
HU - Ungheria 4
PE - Perù 4
TR - Turchia 4
AR - Argentina 3
BG - Bulgaria 3
CH - Svizzera 3
IL - Israele 3
IQ - Iraq 3
ES - Italia 2
LT - Lituania 2
NZ - Nuova Zelanda 2
AM - Armenia 1
CO - Colombia 1
DK - Danimarca 1
EE - Estonia 1
HK - Hong Kong 1
KH - Cambogia 1
LU - Lussemburgo 1
PA - Panama 1
PK - Pakistan 1
RO - Romania 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 13.667
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Città #
Chandler 1.042
Fairfield 1.029
Jacksonville 935
Woodbridge 895
Houston 601
Ashburn 531
Nyköping 505
Ann Arbor 441
Cambridge 441
Seattle 412
Wilmington 358
Singapore 270
Lawrence 218
Nanjing 218
Roxbury 218
Bari 211
Beijing 152
Boardman 136
Des Moines 136
New York 127
Princeton 114
Dearborn 94
Sannicandro di Bari 81
Inglewood 72
Nanchang 69
Jiaxing 56
Shenyang 53
Brooklyn 52
San Diego 49
Santa Clara 48
Los Angeles 45
Brussels 42
Dong Ket 41
Hebei 41
Changsha 40
Tianjin 37
Dublin 25
Milan 24
Pune 24
Helsinki 23
London 21
Paris 21
Shanghai 19
Bitonto 17
Jinan 17
Augusta 16
San Mateo 16
Munich 15
Toronto 15
Washington 15
Brno 14
Guangzhou 14
Hefei 14
Rome 14
Adelfia 13
Falls Church 12
Leawood 12
Ningbo 12
Norwalk 12
Wuhan 12
Ardabil 11
Frankfurt am Main 11
Monmouth Junction 11
San Francisco 11
Tokyo 11
Zhengzhou 11
Redwood City 10
Turin 10
Kunming 9
Taizhou 9
Indiana 8
Santiago 8
Taranto 8
Bologna 7
Florence 7
Auburn Hills 6
Jinhua 6
Kilburn 6
Napoli 6
Chongqing 5
Francavilla Fontana 5
Mumbai 5
Redmond 5
Adelaide 4
Arequipa 4
Baotou 4
Bremen 4
Brescia 4
Casoria 4
Chicago 4
Hangzhou 4
Kornye 4
Pescara 4
Qingdao 4
Stockholm 4
Ulez 4
Valenzano 4
Valparaiso 4
Wallsend 4
Wuxi 4
Totale 10.461
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Nome #
Cheap and environmentally sustainable stereoselective arylketones reduction by Lactobacillus reuteri whole cells 165
Asymmetric Chemoenzymatic Synthesis of 1,3-Diols and 2,4-Disubstituted Aryloxetanes by Using Whole Cell Biocatalysts 150
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability 147
COX-1 Inhibitors: Beyond Structure Toward Therapy 131
A novel injectable formulation of 6-Fluoro-L-DOPA imaging agent for diagnosis of neuroendocrine tumors and Parkinson’s disease 130
Reattività di Nitrilossidi in THF/n-BuLi. Sintesi di 5-Idrossi-Δ2-isossazoline 124
Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues 123
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 122
The reaction of arylaldehydes with hexamethylphosphorous triamide and the use of the resulting products for the synthesis of enamines and deoxybenzoins 120
Effect of mofezolac-galactose distance in conjugates targeting cyclooxygenase (COX)-1 and CNS GLUT-1 carrier 120
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model 119
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6) 119
Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs) 117
PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation 111
3-Aryl-5-vinyl-2-isoxazolines and 3-aryl-5-vinylisoxazoles from aryl nitrile oxides and methyl vinyl ketone lithium enolate: Reaction limits and synthetic utility exploitation 110
Targeting COX-1 by mofezolac-based fluorescent probes for ovarian cancer detection 110
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 110
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 108
1-Aril-5-idrossi-1,2,3-triazoline precursori di Diazometano 106
SLC25A26 overexpression impairs cell function via mtDNA hypermethylation and rewiring of methyl metabolism 106
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 104
Zoledronic acid modulation of TRPV1 channel currents in osteoblast cell line and native rat and mouse bone marrow-derived osteoblasts: Cell proliferation and mineralization effect 104
Update on SAR studies toward new COX-1 selective inhibitors 102
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 101
A chemoenzymatic synthesis of (+)-castanospermine 99
[18F]F-DOPA synthesis by poly(dimethylsiloxane)-based platforms: thermal aging protocol to reduce chemicals-induced damage 99
Procedimento per la sintesi di alcoli chirali mediante impiego di lactobacillus reuteri 98
Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both In Vitro and In Vivo Models of Neuroinflammation 98
Selective cyclooxygenase-1 inhibition by P6 and gastrotoxicity: Preliminary investigation 97
Effect of the aryl group substituent in the dimerization of 3-arylisoxazoles to syn 2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by LDA 96
Stereoselective Chemoenzymatic Synthesis of Optically Active Aryl-Substituted Oxygen-Containing Heterocycles 96
Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase‑1 (COX-1) Inhibitors 96
Recent Developments in the Chemistry of 3-Arylisoxazoles and 3-Aryl-2-isoxazolines 95
Baker's yeast-mediated reduction of ethyl 2-(4-chlorophenoxy)-3-oxoalkanoates intermediates for potential PPARa ligands 95
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 93
Current and emerging applications of fluorine in medicinal chemistry 93
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 93
Harmaline-based scaffold as Human Caseinolytic Protease P (hClpP) inducers for Diffuse Intrinsic Pontine Glioma (DIPG) treatment 91
Intelligent microarray data analysis through non-negative matrix factorization to study human multiple myeloma cell lines 91
Optically active sulfoxides by enantiospecific reactions of bromovinyl aryl sulfoxides with Grignard reagents 90
Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARa Agonists 90
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 90
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity 90
Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells 88
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl) benzamidines by reaction of halobenzonitriles with lithium amides 88
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 88
Synthesis of N,N,N',N'-tetraalkylbenzidines through oxidative coupling of N,N-dialkylarylamines induced by SbCl5 88
Upregulation of beta 3-adrenergic receptor mRNA in human colon cancer: a preliminary study 87
Selective COX-1 inhibition: a therapeutic target to be reconsidered 87
Reaction of 3-phenylisoxazole with alkyllithiums 87
Synthesis of 3-aryl-4,5-dihydro-5-hydroxy-1,2-oxazoles by reaction of substituted benzonitrile oxides with the enolate ion of acetaldehyde 84
Kluyveromyces marxianus CBS 6556 growing cells as a new biocatalyst in the asymmetric reduction of substituted acetophenones 84
Exploring prospects of β3-adrenoceptor agonists and inverse agonists for colon motility control 83
Stereospecific synthesis and absolute configuration of Mexiletine 81
Baker’s yeast-induced asymmetric reduction of a-ketosulfides: synthesis of optically active 1-(benzothiazol-2-ylsulfanyl)-2-alkanols, 2-alkanols, and thiiranes 81
A Novel Synthesis of N-Unsubstituted beta-Enamino Thioesters from 3-Arylisoxazoles and 3-Aryl-5-phenylthio-2-isoxazolines 80
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 79
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
Biocatalytic resolution of (+/-)-hydroxyalkanoic esters. A strategy for enhancing the enantiomeric specificity of lipase-catalyzed ester hydrolysis 78
Regiocontrol by anchimeric coordination in the reactions of organocopper reagents with allylic substrates bearing two leaving groups. Synthesis of optically active homoallylic alcohols 76
Novel pyrazoles and their radiolabeled derivatives useful as COX-1 selective inhibitors 76
Diastereo- and enantio-selective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts 76
5-Hydroxy-3-phenyl-5-vinyl-2-isoxazoline and 3-phenyl-5-vinylisoxazole: synthesis and reactivity (vol 61, pg 11270, 2005) 75
null 75
Bioethanol from biomass model fermentation by Kluyvromyces marxianus CBS6556 73
Five-member-ring heterocycles by reacting enolates with dipoles 73
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 73
Derivati isossazolici e loro impiego come inibitori della ciclossigenasi 72
An efficient C2-homologation of aromatic aldehydes via 5-hydroxyisoxazolidines 72
Decomposition of aryl azides by THF-butyllithium. II. Isolation of 1-aryl-4,5-dihydro-5-hydroxy-1H-1,2,3-triazoles 72
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 71
Beta 3-adrenoceptor ligand development history through patent review 71
A chemoenzymic route to (-)-pyrenophorin 71
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 70
Isoxazole derivatives and their use as cyclooxygenase inhibitors 70
A chemoenzymic route to both enantiomers of betaxolol 69
Chelation-controlled chemo-, regio- and enantio-selective synthesis of homoallylic alcohols 69
Single-dose extended-toxicity preclinical study on novel radiotracer formulations for use in the diagnosis of neuroendocrine tumor and neurodegenerative disorders 69
Beta 3-Adrenoceptor Agonists and (Antagonists as) Inverse Agonists: History, Perspective, Constitutive Activity, and Stereospecific Binding 67
Beta-3 receptor ligands and their use in therapy 65
N-(2,6-Xylil) piperazine and piperidine carboxamides as new antimyotonic agents 65
Screening on the use of Kluyveromyces marxianus CBS 6556 growing cells as enantioselective biocatalyst for ketones reduction 65
C-Alkylation and Michael Addition Involving the Polymer - Supported Carbanion from Methyl Nitroacetate 64
Stereoselective dimerization of 3-arylisoxazoles to cage-shaped bis-β-lactams syn-2,6-diaryl-3,7-diazatricyclo[4.2.0.02,5]octan-4,8-diones induced by hindered lithium amides 64
Reaction of caesium 4-chlorophenate and chlorohydrins from threonines: synthesis of clofibrate analogues 63
N-(2,6-Xylil) piperazine and piperidine carboxamides as new antimyotonic agents 63
Selective reduction of aldehydes to the corresponding primary alcohols by lithium enolate of acetaldehyde 63
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles 63
NOVEL BISPHOSPHONATES, WITH ANTIRESORPTIVE EFFECT IN BONE MINERALIZATION AND OSTEOCLASTOGENESIS, AS MOIETIES OF RA 223-BASED RADIOTRACERS 63
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 62
3-Substituted-5-phenylthio-2-isoxazolines: synthesis and reactions with bases 61
Highly selective COX-1 inhibitors as novel cardioprotective anti-thrombotic agents 61
Synthesis of N,N-dialkylaminobenzonitriles and halo-(N,N-dialkyl)benzamidines by reaction of halobenzonitriles with lithium amides 60
Kinetic resolution of alpha-substituted alpha-aryloxyacetic acid methyl esters by Candida cylindracea lipasi 59
A Chemoenzymatic Route to Enantiomerically Pure ϖ-Trimethylsilil Polyunsaturated Secondary Alcohols 59
6) Stereochemical aspects in structure-activity relationship of heterocyclic compounds active on muscle fiber sodium channels 59
Ligandi del recettore beta-3 adrenergico e loro uso in terapia 59
Enantioselective bio-reduction of prochiral ketones by the non-conventional yeast Kluyveromyces marxianus 59
BETA-3 RECEPTOR LIGANDS AND THEIR USE IN THERAPY 59
Diffuse Intrinsic Pontine Glioma (DIPG): breakthrough and clinical perspective 59
Totale 8.726
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Categoria #
all - tutte 59.790
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.790
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.063 0 0 0 0 319 210 375 230 361 201 305 62
2020/20212.059 297 85 224 85 208 65 153 87 220 291 207 137
2021/20221.614 71 251 27 50 83 107 67 81 104 100 259 414
2022/20232.712 398 255 192 253 373 345 22 301 421 32 66 54
2023/20241.149 70 167 67 71 89 216 56 51 150 64 31 117
2024/2025789 144 66 353 136 90 0 0 0 0 0 0 0
Totale 14.111