The reaction between the arylaldehydes 1a,b and hexamethylphosphorous triamide 2 leads to the [aryl(dimethylamino)methyl]phosphonic bis(dimethylamides) 3a,b. These can be easily deprotonated by butyllithium in 1,2-dimethoxyethane and condensed with arylaldehydes to afford enamines 4a-f or deoxybenzoins 5a-f in fair to good yield.

The reaction of arylaldehydes with hexamethylphosphorous triamide and the use of the resulting products for the synthesis of enamines and deoxybenzoins / BABUDRI F.; FIANDANESE V.; MUSIO R.; NASO F.; SCIAVOVELLI O.; SCILIMATI A. - In: SYNTHESIS. - ISSN 0039-7881. - (3):3(1991), pp. 225-228.

The reaction of arylaldehydes with hexamethylphosphorous triamide and the use of the resulting products for the synthesis of enamines and deoxybenzoins

BABUDRI, Francesco;MUSIO, Roberta;SCILIMATI, Antonio
1991

Abstract

The reaction between the arylaldehydes 1a,b and hexamethylphosphorous triamide 2 leads to the [aryl(dimethylamino)methyl]phosphonic bis(dimethylamides) 3a,b. These can be easily deprotonated by butyllithium in 1,2-dimethoxyethane and condensed with arylaldehydes to afford enamines 4a-f or deoxybenzoins 5a-f in fair to good yield.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/124232
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