A multistep gram-scale synthesis of (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate (2) has been developed. The title compound was prepared starting from commercially available L-DOPA which was O-and N-protected before undergoing iodination by CF 3 CO 2 Ag/I 2 . The structure of the target compound was confirmed using IR, 1 H-NMR, 13 C-NMR, 2D (COSY, HSQC) NMR spectroscopy, as well as ESI-MS and HRMS.
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate
Lentini G.;Cavalluzzi M. M.
;Degennaro L.;Fracchiolla G.;Perna F.;Scilimati A.
2019-01-01
Abstract
A multistep gram-scale synthesis of (S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate (2) has been developed. The title compound was prepared starting from commercially available L-DOPA which was O-and N-protected before undergoing iodination by CF 3 CO 2 Ag/I 2 . The structure of the target compound was confirmed using IR, 1 H-NMR, 13 C-NMR, 2D (COSY, HSQC) NMR spectroscopy, as well as ESI-MS and HRMS.File in questo prodotto:
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