IRIS
BERARDI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 11.768
EU - Europa 5.381
AS - Asia 5.201
SA - Sud America 1.313
AF - Africa 216
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 12
Totale 23.904
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Nazione #
US - Stati Uniti d'America 11.499
SG - Singapore 1.957
DE - Germania 1.371
CN - Cina 1.353
BR - Brasile 1.060
SE - Svezia 929
RU - Federazione Russa 747
IT - Italia 654
HK - Hong Kong 586
VN - Vietnam 573
GB - Regno Unito 516
FI - Finlandia 301
UA - Ucraina 294
FR - Francia 265
CA - Canada 166
IN - India 162
BD - Bangladesh 94
AR - Argentina 92
IQ - Iraq 62
CI - Costa d'Avorio 61
MX - Messico 53
ID - Indonesia 52
JP - Giappone 48
IE - Irlanda 47
PL - Polonia 46
PK - Pakistan 41
EC - Ecuador 40
TR - Turchia 39
ZA - Sudafrica 39
CO - Colombia 35
BE - Belgio 34
AT - Austria 33
VE - Venezuela 32
IR - Iran 28
NL - Olanda 27
SA - Arabia Saudita 27
ES - Italia 26
UZ - Uzbekistan 26
EG - Egitto 22
MA - Marocco 19
CZ - Repubblica Ceca 18
MY - Malesia 18
TN - Tunisia 18
CL - Cile 17
PH - Filippine 17
PY - Paraguay 16
KE - Kenya 14
AE - Emirati Arabi Uniti 12
IL - Israele 12
AU - Australia 11
KR - Corea 11
JO - Giordania 10
NP - Nepal 10
DZ - Algeria 9
ET - Etiopia 9
LT - Lituania 9
RO - Romania 9
AZ - Azerbaigian 8
CR - Costa Rica 8
EU - Europa 8
KZ - Kazakistan 8
PE - Perù 8
BO - Bolivia 7
LY - Libia 7
OM - Oman 7
CH - Svizzera 6
EE - Estonia 6
GT - Guatemala 6
JM - Giamaica 6
RS - Serbia 6
BB - Barbados 5
KG - Kirghizistan 5
NG - Nigeria 5
PT - Portogallo 5
SK - Slovacchia (Repubblica Slovacca) 5
TW - Taiwan 5
UY - Uruguay 5
AL - Albania 4
BG - Bulgaria 4
BH - Bahrain 4
DK - Danimarca 4
GE - Georgia 4
HN - Honduras 4
LB - Libano 4
NI - Nicaragua 4
PA - Panama 4
SN - Senegal 4
TH - Thailandia 4
DO - Repubblica Dominicana 3
GD - Grenada 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
GR - Grecia 2
HU - Ungheria 2
LV - Lettonia 2
MN - Mongolia 2
NZ - Nuova Zelanda 2
QA - Qatar 2
SI - Slovenia 2
Totale 23.875
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Città #
Fairfield 1.214
Singapore 991
Chandler 990
Ashburn 938
Woodbridge 781
Jacksonville 666
Nyköping 591
Hong Kong 576
Houston 574
San Jose 559
Seattle 469
Wilmington 452
Bari 428
Ann Arbor 425
Beijing 422
Cambridge 404
Dallas 351
Dong Ket 274
Roxbury 209
Nanjing 207
Lawrence 204
Lauterbourg 184
New York 166
Princeton 156
Boardman 154
Brooklyn 145
Munich 133
Des Moines 125
Los Angeles 115
São Paulo 100
Ho Chi Minh City 95
Montréal 88
Helsinki 75
Hanoi 72
Mcallen 68
San Diego 66
Inglewood 64
Santa Clara 63
Abidjan 61
London 60
Shenyang 59
Hebei 54
Nanchang 54
Buffalo 51
Dublin 48
Jiaxing 46
Dearborn 44
Tokyo 44
Warsaw 38
Turku 34
Brussels 32
Tianjin 32
Council Bluffs 31
Changsha 30
Montreal 30
Moscow 28
North Bergen 28
Chicago 27
Baghdad 26
Brasília 26
Orem 26
Rio de Janeiro 26
San Francisco 26
Pune 25
Belo Horizonte 24
Denver 24
Frankfurt am Main 24
Paris 24
Atlanta 23
Redwood City 23
Rome 23
Tashkent 23
Guangzhou 22
Shanghai 22
Curitiba 21
Stockholm 20
Guayaquil 19
Romola 19
Toronto 18
Vienna 18
Augusta 17
Chennai 17
Dhaka 17
Leawood 17
San Mateo 17
Jinan 16
Mumbai 16
Amsterdam 15
Ardabil 15
Boston 15
Boydton 15
Jakarta 15
Kansas City 15
Norwalk 15
Phoenix 15
The Dalles 15
Brno 14
Campinas 14
Caracas 14
Johannesburg 14
Totale 15.235
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Nome #
ABC pumps and their role in active drug transport 411
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 227
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 226
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 225
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 214
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 211
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 204
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 201
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 191
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 191
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 188
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 185
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 184
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 183
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 181
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 180
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 178
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 178
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 176
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 174
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 172
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 170
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 170
5 HT1A receptor, an old target for new therapeutic agents 170
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 170
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 170
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 168
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 168
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 166
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 164
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 163
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 162
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 157
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 156
Cyclohexyl-substituted piperazine compounds 156
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 154
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 154
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 152
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 150
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 150
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 150
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 150
METHOD FOR DETERMINING FREE COPPER 149
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 148
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 147
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 147
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 147
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 146
Le applicazioni della chimica farmaceutica 145
Activatable fluorescent probes: a new concept in optical molecular imaging 144
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 144
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 144
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 143
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 143
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 142
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 139
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 139
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 139
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 139
The practice of medicinal chemistry 137
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 137
An innovative small molecule for promoting neuroreparative strategies 137
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 137
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 134
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 134
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 134
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 130
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 129
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 127
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 126
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 126
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 125
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 124
null 124
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 123
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 122
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 121
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 121
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 121
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 120
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 118
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 116
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 116
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 116
Is the sigma-2 receptor a histone binding protein? 116
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 115
Design and synthesis of new selective P-gp substrates and inhibitors. 115
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 115
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 114
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 114
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 114
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 113
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 113
The therapeutic potential of 5-HT1A receptors: a patent review. 113
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 113
Totale 15.279
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Categoria #
all - tutte 94.400
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 94.400
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021767 0 0 0 0 0 0 0 0 0 227 167 373
2021/20221.818 62 218 23 94 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
2024/20253.505 164 55 300 140 71 228 340 306 191 180 503 1.027
2025/20266.086 899 393 613 835 673 425 825 172 664 587 0 0
Totale 24.216