IRIS
BERARDI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 10.871
EU - Europa 5.023
AS - Asia 4.439
SA - Sud America 1.122
AF - Africa 144
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 11
Totale 21.622
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Nazione #
US - Stati Uniti d'America 10.645
SG - Singapore 1.699
DE - Germania 1.364
CN - Cina 1.283
BR - Brasile 964
SE - Svezia 929
RU - Federazione Russa 737
IT - Italia 617
HK - Hong Kong 554
VN - Vietnam 523
GB - Regno Unito 502
UA - Ucraina 285
FI - Finlandia 250
CA - Canada 155
IN - India 96
FR - Francia 74
AR - Argentina 63
CI - Costa d'Avorio 60
IE - Irlanda 44
BD - Bangladesh 40
PL - Polonia 40
MX - Messico 38
AT - Austria 32
BE - Belgio 32
ID - Indonesia 32
JP - Giappone 32
IR - Iran 28
EC - Ecuador 26
ZA - Sudafrica 25
ES - Italia 24
TR - Turchia 24
NL - Olanda 23
IQ - Iraq 21
CZ - Repubblica Ceca 18
UZ - Uzbekistan 17
CO - Colombia 16
CL - Cile 13
PK - Pakistan 13
PY - Paraguay 13
VE - Venezuela 13
EG - Egitto 12
IL - Israele 11
AU - Australia 10
KE - Kenya 9
LT - Lituania 9
MA - Marocco 9
RO - Romania 9
EU - Europa 8
PE - Perù 7
AZ - Azerbaigian 6
EE - Estonia 6
KR - Corea 6
NP - Nepal 6
SA - Arabia Saudita 6
TN - Tunisia 6
BB - Barbados 5
CH - Svizzera 5
DZ - Algeria 5
KZ - Kazakistan 5
NG - Nigeria 5
AE - Emirati Arabi Uniti 4
CR - Costa Rica 4
GE - Georgia 4
JO - Giordania 4
LY - Libia 4
MY - Malesia 4
OM - Oman 4
UY - Uruguay 4
BH - Bahrain 3
BO - Bolivia 3
DK - Danimarca 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
GT - Guatemala 3
HN - Honduras 3
JM - Giamaica 3
KG - Kirghizistan 3
NI - Nicaragua 3
RS - Serbia 3
TT - Trinidad e Tobago 3
TW - Taiwan 3
AL - Albania 2
BG - Bulgaria 2
GD - Grenada 2
GR - Grecia 2
LB - Libano 2
LV - Lettonia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
SN - Senegal 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BY - Bielorussia 1
CW - ???statistics.table.value.countryCode.CW??? 1
DM - Dominica 1
GP - Guadalupe 1
HR - Croazia 1
KW - Kuwait 1
Totale 21.609
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Città #
Fairfield 1.214
Chandler 990
Singapore 842
Ashburn 831
Woodbridge 781
Jacksonville 665
Nyköping 591
Houston 573
Hong Kong 546
Seattle 468
Wilmington 452
Ann Arbor 425
Bari 425
Beijing 414
Cambridge 404
Dallas 345
Dong Ket 274
Roxbury 209
Nanjing 207
Lawrence 204
New York 158
Princeton 156
Boardman 154
Brooklyn 143
Munich 133
Des Moines 122
Los Angeles 112
São Paulo 91
Montréal 88
Ho Chi Minh City 86
Mcallen 68
San Diego 66
Inglewood 64
Abidjan 60
Shenyang 59
London 58
Hanoi 55
Hebei 54
Nanchang 54
Buffalo 50
Santa Clara 49
Jiaxing 46
Dublin 45
Dearborn 44
Turku 34
Warsaw 34
Tianjin 32
Brussels 31
Changsha 30
Tokyo 30
North Bergen 28
Moscow 27
Chicago 26
Brasília 25
San Francisco 25
Denver 24
Helsinki 24
Paris 24
Montreal 23
Pune 23
Redwood City 23
Guangzhou 22
Rio de Janeiro 22
Belo Horizonte 21
Frankfurt am Main 21
Atlanta 20
Shanghai 20
Stockholm 20
Romola 19
Rome 18
Toronto 18
Augusta 17
Leawood 17
San Mateo 17
Vienna 17
Curitiba 16
Ardabil 15
Boydton 15
Jinan 15
Kansas City 15
Brno 14
Chennai 14
Norwalk 14
Orem 14
Phoenix 14
Tashkent 14
Wuhan 14
Campinas 13
Jakarta 13
Mumbai 13
Taizhou 13
Boston 12
Amsterdam 11
Falls Church 11
Johannesburg 11
Nuremberg 11
Haiphong 10
Langenzersdorf 10
Monmouth Junction 10
Ningbo 10
Totale 13.929
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Nome #
ABC pumps and their role in active drug transport 400
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 211
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 210
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 201
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 199
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 194
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 189
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 186
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 181
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 175
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 174
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 172
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 172
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 171
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 170
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 168
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 166
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 165
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 163
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 162
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 158
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 158
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 157
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 156
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 155
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 155
5 HT1A receptor, an old target for new therapeutic agents 154
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 151
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 151
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 150
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 149
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 147
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 146
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 146
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 145
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 145
Cyclohexyl-substituted piperazine compounds 143
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 142
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 141
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 139
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 139
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 138
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 138
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 138
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 137
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 136
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 136
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 135
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 134
Activatable fluorescent probes: a new concept in optical molecular imaging 133
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 133
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 132
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 131
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 131
Le applicazioni della chimica farmaceutica 129
METHOD FOR DETERMINING FREE COPPER 129
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 129
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 129
The practice of medicinal chemistry 128
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 128
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 127
An innovative small molecule for promoting neuroreparative strategies 125
null 124
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 122
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 122
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 122
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 121
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 121
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 120
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 119
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 118
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 117
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 116
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 116
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 116
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 112
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 112
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 111
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 111
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 111
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 109
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 108
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 108
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 107
Design and synthesis of new selective P-gp substrates and inhibitors. 107
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 107
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 107
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 106
Is the sigma-2 receptor a histone binding protein? 106
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 105
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 105
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 105
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 104
The therapeutic potential of 5-HT1A receptors: a patent review. 104
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 104
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 103
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 103
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 103
Totale 13.955
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Categoria #
all - tutte 90.356
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 90.356
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.325 0 0 0 0 0 125 147 110 176 227 167 373
2021/20221.818 62 218 23 94 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
2024/20253.505 164 55 300 140 71 228 340 306 191 180 503 1.027
2025/20263.804 899 393 613 835 673 391 0 0 0 0 0 0
Totale 21.934