IRIS
BERARDI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 13.742
EU - Europa 6.249
AS - Asia 5.319
SA - Sud America 1.346
Continente sconosciuto - Info sul continente non disponibili 324
AF - Africa 218
OC - Oceania 15
Totale 27.213
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Nazione #
US - Stati Uniti d'America 13.436
SG - Singapore 1.983
IT - Italia 1.502
DE - Germania 1.376
CN - Cina 1.375
BR - Brasile 1.068
SE - Svezia 929
RU - Federazione Russa 747
HK - Hong Kong 602
VN - Vietnam 575
GB - Regno Unito 517
FI - Finlandia 301
UA - Ucraina 294
FR - Francia 266
CA - Canada 186
IN - India 162
BD - Bangladesh 135
AR - Argentina 94
IQ - Iraq 62
CI - Costa d'Avorio 61
MX - Messico 56
ID - Indonesia 53
JP - Giappone 49
EC - Ecuador 47
IE - Irlanda 47
PL - Polonia 46
CO - Colombia 43
PK - Pakistan 41
TR - Turchia 40
ZA - Sudafrica 39
VE - Venezuela 35
BE - Belgio 34
AT - Austria 33
NL - Olanda 30
SA - Arabia Saudita 30
ES - Italia 28
IR - Iran 28
UZ - Uzbekistan 26
EG - Egitto 22
CZ - Repubblica Ceca 19
MA - Marocco 19
MY - Malesia 19
PH - Filippine 18
TN - Tunisia 18
CL - Cile 17
PY - Paraguay 17
KE - Kenya 15
AU - Australia 13
AE - Emirati Arabi Uniti 12
CR - Costa Rica 12
IL - Israele 12
KR - Corea 11
JO - Giordania 10
NP - Nepal 10
PE - Perù 10
RO - Romania 10
DZ - Algeria 9
ET - Etiopia 9
LT - Lituania 9
AZ - Azerbaigian 8
CH - Svizzera 8
EU - Europa 8
JM - Giamaica 8
KZ - Kazakistan 8
BO - Bolivia 7
GT - Guatemala 7
LY - Libia 7
OM - Oman 7
TH - Thailandia 7
TT - Trinidad e Tobago 7
UY - Uruguay 7
EE - Estonia 6
NI - Nicaragua 6
RS - Serbia 6
BB - Barbados 5
HN - Honduras 5
KG - Kirghizistan 5
NG - Nigeria 5
PT - Portogallo 5
SK - Slovacchia (Repubblica Slovacca) 5
TW - Taiwan 5
AL - Albania 4
BG - Bulgaria 4
BH - Bahrain 4
DK - Danimarca 4
GE - Georgia 4
LB - Libano 4
PA - Panama 4
SN - Senegal 4
DO - Repubblica Dominicana 3
GD - Grenada 3
HR - Croazia 3
HU - Ungheria 3
PS - Palestinian Territory 3
SY - Repubblica araba siriana 3
GR - Grecia 2
LV - Lettonia 2
MD - Moldavia 2
MN - Mongolia 2
NZ - Nuova Zelanda 2
Totale 26.869
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Città #
Fairfield 1.214
Los Angeles 1.039
Singapore 1.006
Chandler 990
Ashburn 967
Woodbridge 781
San Jose 780
Jacksonville 669
Hong Kong 592
Nyköping 591
Houston 581
Milan 475
Seattle 469
Wilmington 455
Bari 435
Beijing 432
Ann Arbor 425
Cambridge 404
Dallas 362
Council Bluffs 278
Dong Ket 274
Roxbury 209
Nanjing 207
Lawrence 204
New York 193
Lauterbourg 184
Boardman 174
Princeton 156
Rome 155
Brooklyn 148
Munich 133
Des Moines 125
São Paulo 102
Ho Chi Minh City 96
Santa Clara 92
Montréal 88
Helsinki 75
Hanoi 72
Mcallen 68
San Diego 66
Inglewood 64
Buffalo 62
Abidjan 61
London 60
Shenyang 59
Hebei 54
Nanchang 54
Chicago 50
Dublin 48
Jiaxing 46
Tokyo 45
Dearborn 44
Phoenix 43
Columbus 38
Warsaw 38
Figino 35
Turku 34
Tianjin 33
Brussels 32
Montreal 32
Changsha 30
North Bergen 29
San Francisco 29
Moscow 28
Brasília 27
Atlanta 26
Baghdad 26
Denver 26
Frankfurt am Main 26
Orem 26
Rio de Janeiro 26
Pune 25
Belo Horizonte 24
Paris 24
Redwood City 24
Shanghai 23
Tashkent 23
Turin 23
Guangzhou 22
Curitiba 21
Guayaquil 20
Stockholm 20
Toronto 20
Catania 19
Romola 19
Dhaka 18
Vienna 18
Augusta 17
Chennai 17
Leawood 17
San Mateo 17
Amsterdam 16
Jinan 16
Mumbai 16
Norwalk 16
Ardabil 15
Boston 15
Boydton 15
Campinas 15
Caracas 15
Totale 17.547
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Nome #
ABC pumps and their role in active drug transport 417
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 297
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 252
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 242
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 238
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 238
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 225
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 224
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 222
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 221
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 216
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 214
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 210
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 208
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 206
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 203
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 201
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 197
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 195
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 194
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 193
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 193
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 193
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 192
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 191
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 191
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 190
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 188
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 187
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 186
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 185
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 185
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 184
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 184
5 HT1A receptor, an old target for new therapeutic agents 183
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 182
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 180
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 180
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 179
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 178
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 178
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 176
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 176
Is the sigma-2 receptor a histone binding protein? 175
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 174
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 174
Cyclohexyl-substituted piperazine compounds 173
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 173
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 170
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 168
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 168
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 167
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 165
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 164
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 163
METHOD FOR DETERMINING FREE COPPER 162
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 161
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 161
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 160
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 160
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 155
Le applicazioni della chimica farmaceutica 155
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 155
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 155
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 154
Activatable fluorescent probes: a new concept in optical molecular imaging 153
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 153
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 153
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 152
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 152
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 150
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 149
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 149
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 149
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 148
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 147
The practice of medicinal chemistry 146
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 146
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 146
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 146
An innovative small molecule for promoting neuroreparative strategies 145
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 144
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 144
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 141
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 137
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 136
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 133
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 133
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 133
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 130
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 130
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 129
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 125
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 125
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 125
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 125
null 124
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 124
Design and synthesis of new selective P-gp substrates and inhibitors. 122
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 122
Totale 17.352
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Categoria #
all - tutte 105.196
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.196
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.538 0 0 23 94 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
2024/20253.505 164 55 300 140 71 228 340 306 191 180 503 1.027
2025/20267.298 899 393 613 835 673 425 825 172 664 684 229 886
2026/20271.785 1.057 420 308 0 0 0 0 0 0 0 0 0
Totale 27.213