IRIS
BERARDI, Francesco
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.229
EU - Europa 4.292
AS - Asia 1.708
SA - Sud America 15
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 9
AF - Africa 7
Totale 15.272
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 9.122
DE - Germania 1.276
CN - Cina 953
SE - Svezia 909
IT - Italia 597
GB - Regno Unito 434
RU - Federazione Russa 402
SG - Singapore 368
UA - Ucraina 276
VN - Vietnam 276
FI - Finlandia 215
CA - Canada 106
FR - Francia 54
IE - Irlanda 43
IN - India 43
BE - Belgio 31
IR - Iran 27
CZ - Repubblica Ceca 15
AU - Australia 10
HK - Hong Kong 9
NL - Olanda 9
EU - Europa 8
ID - Indonesia 8
CL - Cile 7
RO - Romania 7
ES - Italia 5
CH - Svizzera 4
JP - Giappone 4
KR - Corea 4
LT - Lituania 4
PL - Polonia 4
TR - Turchia 4
BR - Brasile 3
IL - Israele 3
LY - Libia 3
PE - Perù 3
GE - Georgia 2
MY - Malesia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TH - Thailandia 2
TW - Taiwan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
CO - Colombia 1
EG - Egitto 1
GR - Grecia 1
KZ - Kazakistan 1
LV - Lettonia 1
MX - Messico 1
RS - Serbia 1
ZW - Zimbabwe 1
Totale 15.272
Salva come PNG Salva come JPEG
Città #
Fairfield 1.213
Chandler 990
Woodbridge 781
Jacksonville 665
Nyköping 591
Houston 562
Ashburn 526
Seattle 461
Wilmington 451
Ann Arbor 425
Bari 424
Cambridge 403
Singapore 294
Dong Ket 274
Roxbury 209
Beijing 208
Nanjing 207
Lawrence 204
Princeton 156
Boardman 154
Des Moines 122
Brooklyn 112
New York 110
Montréal 88
Munich 77
Mcallen 68
Inglewood 64
San Diego 62
Shenyang 59
Hebei 54
Nanchang 54
Jiaxing 46
Dearborn 44
Dublin 43
London 37
Brussels 31
Los Angeles 31
Tianjin 31
Changsha 30
Helsinki 23
Redwood City 23
Santa Clara 23
Pune 22
Guangzhou 20
Paris 20
Romola 19
Rome 18
Leawood 17
San Mateo 17
Shanghai 16
Ardabil 15
Augusta 15
Boydton 15
Jinan 15
Brno 14
Norwalk 14
San Francisco 13
Wuhan 13
Frankfurt am Main 12
Kansas City 12
Taizhou 12
Falls Church 11
Toronto 11
Monmouth Junction 10
Ningbo 10
Zhengzhou 10
Catania 9
Indiana 9
Wuxi 9
Hefei 8
West Jordan 8
Jinhua 7
Chiswick 6
Kilburn 6
Quanzhou 6
Yiwu 6
Hong Kong 5
Mumbai 5
Nuremberg 5
Washington 5
Acton 4
Fuzhou 4
Madrid 4
Ottawa 4
Prescot 4
Strasbourg 4
Sydney 4
Amsterdam 3
Chizhou 3
Detroit 3
Hounslow 3
Islington 3
Lima 3
Marlborough 3
Melbourne 3
Nürnberg 3
Sabz 3
Zurich 3
Auburn Hills 2
Auckland 2
Totale 10.940
Salva come PNG Salva come JPEG
Nome #
ABC pumps and their role in active drug transport 360
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 171
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 157
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 153
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 152
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 150
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 150
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 134
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 133
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 133
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 132
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 129
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 128
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 125
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 125
null 124
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 123
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 118
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 118
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 116
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 114
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 113
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 111
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 111
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 111
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 109
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 109
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 108
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 108
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 107
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 107
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 105
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 103
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 101
5 HT1A receptor, an old target for new therapeutic agents 101
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 101
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 100
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 99
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 98
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 98
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 97
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 97
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 97
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 97
The practice of medicinal chemistry 96
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 96
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 96
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 96
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 96
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 95
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 95
Le applicazioni della chimica farmaceutica 94
Cyclohexyl-substituted piperazine compounds 94
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 93
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 92
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 91
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 91
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 90
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 89
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 88
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 87
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 87
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 87
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 86
Activatable fluorescent probes: a new concept in optical molecular imaging 86
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 86
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 86
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 85
METHOD FOR DETERMINING FREE COPPER 85
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 84
The therapeutic potential of 5-HT1A receptors: a patent review. 84
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 84
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 83
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 83
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 83
Design and synthesis of new selective P-gp substrates and inhibitors. 83
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 82
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 82
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 82
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 81
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 80
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 80
null 80
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 80
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 79
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 79
null 79
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 79
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 78
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 77
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 77
An innovative small molecule for promoting neuroreparative strategies 77
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 77
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 76
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 76
Is the sigma-2 receptor a histone binding protein? 76
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 75
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 75
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
Totale 10.197
Salva come PNG Salva come JPEG
Categoria #
all - tutte 63.689
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.689
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.988 0 0 0 0 0 209 363 292 399 250 333 142
2020/20212.183 185 179 155 151 188 125 147 110 176 227 167 373
2021/20221.818 62 218 23 94 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
2024/2025957 164 55 300 140 71 227 0 0 0 0 0 0
Totale 15.582