IRIS
BERARDI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 9.047
EU - Europa 4.020
AS - Asia 1.216
SA - Sud America 15
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 9
AF - Africa 5
Totale 14.324
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Nazione #
US - Stati Uniti d'America 8.951
DE - Germania 1.259
SE - Svezia 909
CN - Cina 818
IT - Italia 543
GB - Regno Unito 430
UA - Ucraina 276
VN - Vietnam 275
RU - Federazione Russa 218
FI - Finlandia 209
CA - Canada 95
FR - Francia 53
IE - Irlanda 43
IN - India 43
BE - Belgio 31
IR - Iran 27
SG - Singapore 20
CZ - Repubblica Ceca 15
AU - Australia 10
EU - Europa 8
ID - Indonesia 8
CL - Cile 7
RO - Romania 7
NL - Olanda 6
ES - Italia 5
CH - Svizzera 4
HK - Hong Kong 4
PL - Polonia 4
TR - Turchia 4
BR - Brasile 3
IL - Israele 3
JP - Giappone 3
KR - Corea 3
LY - Libia 3
PE - Perù 3
GE - Georgia 2
MY - Malesia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
TH - Thailandia 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
CO - Colombia 1
EG - Egitto 1
GR - Grecia 1
KZ - Kazakistan 1
LT - Lituania 1
LV - Lettonia 1
MX - Messico 1
RS - Serbia 1
TW - Taiwan 1
ZW - Zimbabwe 1
Totale 14.324
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Città #
Fairfield 1.213
Chandler 990
Woodbridge 781
Jacksonville 665
Nyköping 591
Houston 562
Ashburn 522
Seattle 461
Wilmington 451
Ann Arbor 425
Bari 422
Cambridge 403
Dong Ket 274
Roxbury 209
Nanjing 207
Lawrence 204
Beijing 199
Princeton 156
Boardman 126
Des Moines 122
Brooklyn 112
New York 110
Montréal 88
Mcallen 68
Munich 66
Inglewood 64
San Diego 62
Shenyang 58
Hebei 54
Nanchang 54
Dearborn 44
Dublin 43
Jiaxing 43
London 34
Brussels 31
Tianjin 31
Changsha 30
Redwood City 23
Pune 22
Los Angeles 21
Paris 20
Helsinki 17
Leawood 17
San Mateo 17
Ardabil 15
Augusta 15
Boydton 15
Jinan 15
Brno 14
Norwalk 14
Guangzhou 13
Rome 13
San Francisco 13
Singapore 13
Kansas City 12
Falls Church 11
Taizhou 11
Monmouth Junction 10
Ningbo 10
Frankfurt am Main 9
Indiana 9
Zhengzhou 9
Hefei 8
West Jordan 8
Catania 7
Chiswick 6
Kilburn 6
Mumbai 5
Shanghai 5
Washington 5
Acton 4
Fuzhou 4
Madrid 4
Nuremberg 4
Prescot 4
Strasbourg 4
Sydney 4
Toronto 4
Yiwu 4
Detroit 3
Hounslow 3
Islington 3
Jinhua 3
Lima 3
Melbourne 3
Nürnberg 3
Quanzhou 3
Sabz 3
Wuhan 3
Zurich 3
Auburn Hills 2
Auckland 2
Aveiro 2
Bangalore 2
Bangkok 2
Baotou 2
Bremen 2
Bucharest 2
Canberra 2
Central 2
Totale 10.472
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Nome #
ABC pumps and their role in active drug transport 355
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 165
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 149
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 147
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 146
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 144
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 141
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 130
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 128
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 124
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 124
null 123
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 123
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 123
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 121
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 120
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 116
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 115
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 111
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 111
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 107
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 107
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 107
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 106
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 105
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 105
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 105
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 104
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 104
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 102
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 99
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 99
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 96
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 95
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 95
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 95
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 95
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 94
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 94
5 HT1A receptor, an old target for new therapeutic agents 94
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 94
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 93
Le applicazioni della chimica farmaceutica 92
The practice of medicinal chemistry 92
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 91
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 91
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 91
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 90
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 90
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 89
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 89
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 89
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 87
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 85
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 85
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 84
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 84
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 84
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 83
The therapeutic potential of 5-HT1A receptors: a patent review. 82
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 82
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 82
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 81
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 81
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 80
null 80
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 80
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 79
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 79
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 79
Activatable fluorescent probes: a new concept in optical molecular imaging 79
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 79
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 79
Design and synthesis of new selective P-gp substrates and inhibitors. 79
Cyclohexyl-substituted piperazine compounds 79
METHOD FOR DETERMINING FREE COPPER 79
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 78
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 78
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 78
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 78
null 78
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 77
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 77
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 77
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 77
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 76
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 76
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 74
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 73
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 73
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 73
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 73
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 73
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 72
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 72
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 71
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 71
Is the sigma-2 receptor a histone binding protein? 70
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 70
Totale 9.653
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Categoria #
all - tutte 54.712
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.712
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019444 0 0 0 0 0 0 0 0 0 0 0 444
2019/20203.491 596 177 122 290 318 209 363 292 399 250 333 142
2020/20212.183 185 179 155 151 188 125 147 110 176 227 167 373
2021/20221.818 62 218 23 94 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
Totale 14.625