IRIS
BERARDI, Francesco
 Distribuzione geografica
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Continente #
NA - Nord America 14.734
EU - Europa 6.387
AS - Asia 5.340
SA - Sud America 1.368
Continente sconosciuto - Info sul continente non disponibili 335
AF - Africa 224
OC - Oceania 15
Totale 28.403
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Nazione #
US - Stati Uniti d'America 14.266
SG - Singapore 1.985
IT - Italia 1.576
DE - Germania 1.383
CN - Cina 1.376
BR - Brasile 1.090
SE - Svezia 930
RU - Federazione Russa 775
HK - Hong Kong 602
VN - Vietnam 575
GB - Regno Unito 526
FI - Finlandia 301
UA - Ucraina 296
FR - Francia 268
CA - Canada 247
IN - India 162
BD - Bangladesh 135
AR - Argentina 94
IQ - Iraq 62
CI - Costa d'Avorio 61
MX - Messico 57
ID - Indonesia 53
JP - Giappone 49
EC - Ecuador 47
IE - Irlanda 47
PL - Polonia 47
CO - Colombia 43
PK - Pakistan 41
TR - Turchia 40
ZA - Sudafrica 39
BE - Belgio 35
VE - Venezuela 35
AT - Austria 34
NL - Olanda 34
SA - Arabia Saudita 30
ES - Italia 28
IR - Iran 28
IL - Israele 26
UZ - Uzbekistan 26
CR - Costa Rica 23
EG - Egitto 22
GT - Guatemala 21
PH - Filippine 20
CZ - Repubblica Ceca 19
MA - Marocco 19
MY - Malesia 19
TN - Tunisia 18
CL - Cile 17
PR - Porto Rico 17
PY - Paraguay 17
TT - Trinidad e Tobago 17
JM - Giamaica 16
KE - Kenya 15
SV - El Salvador 15
LT - Lituania 14
NI - Nicaragua 14
AU - Australia 13
AE - Emirati Arabi Uniti 12
CW - ???statistics.table.value.countryCode.CW??? 12
HN - Honduras 12
KR - Corea 11
JO - Giordania 10
NP - Nepal 10
PE - Perù 10
RO - Romania 10
DZ - Algeria 9
ET - Etiopia 9
AZ - Azerbaigian 8
CH - Svizzera 8
EE - Estonia 8
EU - Europa 8
GP - Guadalupe 8
KZ - Kazakistan 8
TH - Thailandia 8
BO - Bolivia 7
LY - Libia 7
OM - Oman 7
SC - Seychelles 7
UY - Uruguay 7
RS - Serbia 6
BB - Barbados 5
DK - Danimarca 5
KG - Kirghizistan 5
NG - Nigeria 5
PT - Portogallo 5
SK - Slovacchia (Repubblica Slovacca) 5
TW - Taiwan 5
AL - Albania 4
BG - Bulgaria 4
BH - Bahrain 4
GE - Georgia 4
LB - Libano 4
PA - Panama 4
SN - Senegal 4
BS - Bahamas 3
DO - Repubblica Dominicana 3
GD - Grenada 3
HR - Croazia 3
HU - Ungheria 3
PS - Palestinian Territory 3
Totale 28.048
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Città #
Fairfield 1.215
Ashburn 1.176
Los Angeles 1.053
Singapore 1.006
Chandler 990
San Jose 940
Woodbridge 781
Jacksonville 669
Hong Kong 592
Nyköping 591
Houston 581
Milan 483
Seattle 469
Wilmington 455
Bari 436
Beijing 432
Ann Arbor 425
Cambridge 404
Dallas 366
Council Bluffs 278
Dong Ket 274
New York 225
Roxbury 209
Nanjing 207
Lawrence 204
Lauterbourg 184
Boardman 175
Rome 160
Princeton 156
Brooklyn 152
Munich 133
Des Moines 125
São Paulo 123
Santa Clara 107
Ho Chi Minh City 96
Montréal 88
Helsinki 75
Hanoi 72
Washington 72
Mcallen 68
San Diego 67
Inglewood 64
Buffalo 62
Abidjan 61
London 60
Shenyang 59
Hebei 54
Nanchang 54
Phoenix 51
Chicago 50
Dublin 48
Jiaxing 46
Tokyo 45
Dearborn 44
Warsaw 39
Columbus 38
Montreal 37
Figino 36
Turku 34
Brussels 33
North Bergen 33
Tianjin 33
Toronto 32
Atlanta 31
Changsha 30
San Francisco 30
Moscow 28
Brasília 27
Frankfurt am Main 27
Orem 27
Turin 27
Baghdad 26
Denver 26
Rio de Janeiro 26
Pune 25
Belo Horizonte 24
Paris 24
Redwood City 24
Shanghai 23
Tashkent 23
Guangzhou 22
Curitiba 21
Stockholm 21
Guayaquil 20
Catania 19
Naples 19
Romola 19
San José 19
Vienna 19
Dhaka 18
Amsterdam 17
Augusta 17
Chennai 17
Leawood 17
San Mateo 17
Jinan 16
Mumbai 16
Norwalk 16
Ardabil 15
Boston 15
Totale 18.135
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Nome #
ABC pumps and their role in active drug transport 423
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 307
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 261
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 254
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 249
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 243
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 235
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 233
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 226
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 225
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 221
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 220
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 218
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 214
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 213
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 211
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 209
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 207
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 204
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 203
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 200
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 199
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 199
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 196
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 196
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 196
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 196
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 194
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 194
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 193
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 190
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 190
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 189
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 189
Is the sigma-2 receptor a histone binding protein? 188
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 187
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 187
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 187
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 187
5 HT1A receptor, an old target for new therapeutic agents 186
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 186
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 184
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 183
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 182
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 181
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 180
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 179
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 177
Cyclohexyl-substituted piperazine compounds 176
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 175
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 174
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 174
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 173
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 170
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 169
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 169
METHOD FOR DETERMINING FREE COPPER 167
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 166
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 166
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 163
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 161
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 160
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 160
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 159
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 159
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 158
Le applicazioni della chimica farmaceutica 157
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 157
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 157
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 156
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 156
Activatable fluorescent probes: a new concept in optical molecular imaging 155
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 155
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 155
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 155
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 154
An innovative small molecule for promoting neuroreparative strategies 154
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 153
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 153
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 151
The practice of medicinal chemistry 149
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 149
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 148
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 146
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 144
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 144
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 143
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 139
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 139
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 138
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 135
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 134
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 133
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 133
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 133
Design and synthesis of new selective P-gp substrates and inhibitors. 130
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 129
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 129
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 128
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 127
Totale 17.988
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Categoria #
all - tutte 109.721
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 109.721
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.421 0 0 0 0 122 174 114 83 128 116 297 387
2022/20232.652 465 298 158 222 387 302 21 274 433 21 35 36
2023/2024861 77 164 41 63 66 178 13 19 47 28 17 148
2024/20253.505 164 55 300 140 71 228 340 306 191 180 503 1.027
2025/20267.298 899 393 613 835 673 425 825 172 664 684 229 886
2026/20272.975 1.057 420 516 920 62 0 0 0 0 0 0 0
Totale 28.403