IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 6.583
EU - Europa 2.752
AS - Asia 2.657
SA - Sud America 652
AF - Africa 104
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 5
Totale 12.758
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Nazione #
US - Stati Uniti d'America 6.471
SG - Singapore 991
DE - Germania 713
CN - Cina 643
BR - Brasile 521
RU - Federazione Russa 414
SE - Svezia 412
IT - Italia 351
HK - Hong Kong 320
GB - Regno Unito 258
VN - Vietnam 236
FI - Finlandia 162
FR - Francia 133
IN - India 78
UA - Ucraina 64
CA - Canada 54
ID - Indonesia 53
AR - Argentina 50
JP - Giappone 49
BD - Bangladesh 46
IQ - Iraq 38
BE - Belgio 34
PK - Pakistan 33
PL - Polonia 32
NL - Olanda 30
MX - Messico 29
AT - Austria 28
ES - Italia 24
CI - Costa d'Avorio 23
IE - Irlanda 23
ZA - Sudafrica 23
CZ - Repubblica Ceca 19
EC - Ecuador 19
SA - Arabia Saudita 18
CO - Colombia 17
KR - Corea 15
MY - Malesia 15
TR - Turchia 15
TW - Taiwan 15
MA - Marocco 14
VE - Venezuela 13
IR - Iran 12
UZ - Uzbekistan 12
CL - Cile 11
PH - Filippine 10
EG - Egitto 9
LT - Lituania 9
JO - Giordania 8
KE - Kenya 7
PY - Paraguay 7
AL - Albania 6
CR - Costa Rica 6
LB - Libano 6
PE - Perù 6
SK - Slovacchia (Repubblica Slovacca) 6
TN - Tunisia 6
DK - Danimarca 5
IL - Israele 5
LY - Libia 5
OM - Oman 5
RO - Romania 5
AE - Emirati Arabi Uniti 4
AU - Australia 4
AZ - Azerbaigian 4
BO - Bolivia 4
DZ - Algeria 4
ET - Etiopia 4
JM - Giamaica 4
KG - Kirghizistan 4
KZ - Kazakistan 4
PT - Portogallo 4
BB - Barbados 3
BG - Bulgaria 3
CH - Svizzera 3
EU - Europa 3
NP - Nepal 3
CY - Cipro 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
GT - Guatemala 2
GY - Guiana 2
HU - Ungheria 2
MK - Macedonia 2
MN - Mongolia 2
NI - Nicaragua 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
ZW - Zimbabwe 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AM - Armenia 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BS - Bahamas 1
BT - Bhutan 1
BW - Botswana 1
DO - Repubblica Dominicana 1
EE - Estonia 1
Totale 12.736
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Città #
Dallas 909
Fairfield 634
Ashburn 577
Singapore 501
Woodbridge 401
Chandler 396
Houston 356
Hong Kong 300
Seattle 291
San Jose 286
Nyköping 270
Ann Arbor 255
Beijing 239
Wilmington 226
Cambridge 222
Bari 167
Jacksonville 148
New York 87
Lauterbourg 85
Helsinki 82
Roxbury 80
Lawrence 79
Brooklyn 65
Los Angeles 65
Munich 64
Nanjing 63
Council Bluffs 59
Dong Ket 59
Ho Chi Minh City 59
Princeton 54
São Paulo 48
Boardman 45
Des Moines 45
Hanoi 41
Santa Clara 41
Tokyo 40
Buffalo 37
Jakarta 35
London 35
San Diego 32
Inglewood 30
Brussels 29
North Bergen 25
Chicago 24
Dublin 24
Abidjan 23
Moscow 22
Shenyang 22
Hebei 21
Kansas City 21
Baghdad 19
Jiaxing 19
Frankfurt am Main 18
Orem 18
Warsaw 17
Denver 16
Nanchang 16
Turku 15
Brno 14
Johannesburg 14
Montreal 14
Paris 14
Rio de Janeiro 14
Atlanta 13
Falkenstein 13
Milan 12
San Francisco 12
Stockholm 12
Boston 11
Chennai 11
Nuremberg 11
Phoenix 11
Rome 11
Tashkent 11
Tianjin 11
Vienna 11
Augusta 10
Catania 10
Dearborn 10
Guangzhou 10
Mumbai 10
Salt Lake City 10
The Dalles 10
Toronto 10
Haiphong 9
Jeddah 9
Lahore 9
Redwood City 9
Shanghai 9
Amsterdam 8
Buenos Aires 8
Changsha 8
Düsseldorf 8
Groningen 8
Karachi 8
Langenzersdorf 8
Leawood 8
Mexico City 8
Salvador 8
San Mateo 8
Totale 8.290
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.089
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 216
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 214
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 204
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 202
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 201
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 196
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 191
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 191
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 189
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 182
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 178
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 176
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 174
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 172
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 170
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 170
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 166
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 165
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 162
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 161
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 160
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 157
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 156
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 154
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 153
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 152
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 150
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 150
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 147
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 147
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 147
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 144
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 142
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 139
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 139
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 137
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 137
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 134
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 133
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 132
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 130
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 127
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 126
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 120
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 118
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 118
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 117
Is the sigma-2 receptor a histone binding protein? 116
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 115
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 115
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 114
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 114
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 111
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 111
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 110
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 109
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 109
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 109
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 108
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 107
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 106
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 106
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 106
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 104
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 102
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 101
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 93
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 92
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 90
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 89
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 84
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Why PB28 Could Be a Covid 2019 Game Changer? 78
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 76
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 75
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 72
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 70
null 68
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 68
Small molecules and acridone derivatives as P-gp inhibitors 67
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 65
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 65
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 65
In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 61
New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases 60
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 59
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 59
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 58
Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor 57
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 52
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 50
Exploring Selenium-Functionalized Hydroxyapatite Using Organic Selenocystine for Antitumor Applications 44
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 42
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 38
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties 35
Totale 13.058
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Categoria #
all - tutte 47.801
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.801
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021341 0 0 0 0 0 0 0 0 0 111 107 123
2021/2022774 38 77 17 26 46 81 46 41 69 61 113 159
2022/20231.132 183 148 71 84 142 144 11 126 171 7 20 25
2023/2024420 33 61 21 41 34 91 20 14 16 11 9 69
2024/20251.896 92 27 140 105 39 131 258 134 105 109 256 500
2025/20264.487 513 417 936 473 458 234 460 138 477 381 0 0
Totale 13.134