IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 6.000
EU - Europa 2.452
AS - Asia 2.084
SA - Sud America 532
AF - Africa 60
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 3
Totale 11.136
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Nazione #
US - Stati Uniti d'America 5.927
SG - Singapore 805
DE - Germania 695
CN - Cina 585
BR - Brasile 458
RU - Federazione Russa 409
SE - Svezia 407
IT - Italia 291
HK - Hong Kong 289
GB - Regno Unito 244
VN - Vietnam 172
FI - Finlandia 91
UA - Ucraina 62
IN - India 46
ID - Indonesia 42
FR - Francia 41
CA - Canada 33
AR - Argentina 32
BE - Belgio 31
AT - Austria 27
NL - Olanda 27
PL - Polonia 27
JP - Giappone 24
IE - Irlanda 23
CI - Costa d'Avorio 22
BD - Bangladesh 21
ES - Italia 19
MX - Messico 19
CZ - Repubblica Ceca 18
ZA - Sudafrica 14
IQ - Iraq 13
EC - Ecuador 12
IR - Iran 12
PK - Pakistan 12
LT - Lituania 9
KR - Corea 7
TR - Turchia 7
CO - Colombia 6
TW - Taiwan 6
CL - Cile 5
IL - Israele 5
KE - Kenya 5
PE - Perù 5
PY - Paraguay 5
RO - Romania 5
SA - Arabia Saudita 5
AL - Albania 4
DK - Danimarca 4
MA - Marocco 4
MY - Malesia 4
UZ - Uzbekistan 4
VE - Venezuela 4
AU - Australia 3
AZ - Azerbaigian 3
BB - Barbados 3
BG - Bulgaria 3
EU - Europa 3
JM - Giamaica 3
JO - Giordania 3
KZ - Kazakistan 3
LY - Libia 3
TN - Tunisia 3
AE - Emirati Arabi Uniti 2
CH - Svizzera 2
CR - Costa Rica 2
EG - Egitto 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
GY - Guiana 2
KG - Kirghizistan 2
LB - Libano 2
MK - Macedonia 2
NI - Nicaragua 2
OM - Oman 2
SK - Slovacchia (Repubblica Slovacca) 2
UY - Uruguay 2
A2 - ???statistics.table.value.countryCode.A2??? 1
BA - Bosnia-Erzegovina 1
BO - Bolivia 1
BW - Botswana 1
CY - Cipro 1
DO - Repubblica Dominicana 1
DZ - Algeria 1
EE - Estonia 1
ET - Etiopia 1
GP - Guadalupe 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
HT - Haiti 1
KH - Cambogia 1
KN - Saint Kitts e Nevis 1
LU - Lussemburgo 1
LV - Lettonia 1
ME - Montenegro 1
ML - Mali 1
MN - Mongolia 1
NG - Nigeria 1
NP - Nepal 1
Totale 11.127
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Città #
Dallas 903
Fairfield 634
Ashburn 508
Woodbridge 400
Chandler 396
Singapore 393
Houston 354
Seattle 291
Hong Kong 279
Nyköping 270
Ann Arbor 255
Beijing 232
Wilmington 226
Cambridge 222
Bari 166
Jacksonville 147
New York 85
Roxbury 80
Lawrence 79
Brooklyn 64
Munich 64
Nanjing 63
Dong Ket 59
Princeton 54
Los Angeles 51
Boardman 45
Des Moines 44
Ho Chi Minh City 44
São Paulo 39
Buffalo 35
London 33
Santa Clara 33
Jakarta 32
San Diego 32
Inglewood 30
Brussels 27
Dublin 24
Council Bluffs 23
North Bergen 23
Abidjan 22
Chicago 22
Hanoi 21
Hebei 21
Kansas City 21
Shenyang 21
Moscow 20
Jiaxing 19
Tokyo 19
Nanchang 16
Turku 15
Brno 14
Denver 14
Warsaw 14
Paris 13
Helsinki 11
Johannesburg 11
Rio de Janeiro 11
San Francisco 11
Tianjin 11
Boston 10
Dearborn 10
Frankfurt am Main 10
Guangzhou 10
Nuremberg 10
Phoenix 10
The Dalles 10
Vienna 10
Atlanta 9
Augusta 9
Milan 9
Redwood City 9
Shanghai 9
Changsha 8
Chennai 8
Düsseldorf 8
Groningen 8
Langenzersdorf 8
Leawood 8
Montreal 8
Mumbai 8
San Mateo 8
Santiago de Compostela 8
Toronto 8
Ardabil 7
Catania 7
Columbus 7
Fragagnano 7
Pune 7
Rome 7
Salt Lake City 7
Stockholm 7
Amsterdam 6
Belo Horizonte 6
Brasília 6
Curitiba 6
Falkenstein 6
Franca 6
Manchester 6
Mexico City 6
Monmouth Junction 6
Totale 7.389
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.057
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 197
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 191
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 187
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 184
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 180
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 180
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 177
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 173
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 170
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 165
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 163
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 162
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 159
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 154
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 152
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 151
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 148
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 147
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 147
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 144
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 144
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 143
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 141
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 140
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 139
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 138
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 137
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 134
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 134
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 131
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 131
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 130
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 129
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 128
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 128
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 126
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 125
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 121
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 121
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 120
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 119
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 119
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 115
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 114
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 110
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 109
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 106
Is the sigma-2 receptor a histone binding protein? 105
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 104
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 103
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 102
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 101
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 101
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 101
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 101
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 100
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 99
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 99
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 97
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 96
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 96
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 96
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 95
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 82
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 81
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Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 73
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 72
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 71
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 68
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Why PB28 Could Be a Covid 2019 Game Changer? 68
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 62
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 61
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 60
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 59
Small molecules and acridone derivatives as P-gp inhibitors 58
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 58
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 57
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 55
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 54
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 54
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 53
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 50
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 46
New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases 44
Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor 43
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 41
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 39
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 38
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 38
In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 35
Exploring Selenium-Functionalized Hydroxyapatite Using Organic Selenocystine for Antitumor Applications 31
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 30
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties 30
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 24
Totale 11.489
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Categoria #
all - tutte 44.823
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.823
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021646 0 0 0 0 0 72 71 69 93 111 107 123
2021/2022774 38 77 17 26 46 81 46 41 69 61 113 159
2022/20231.132 183 148 71 84 142 144 11 126 171 7 20 25
2023/2024420 33 61 21 41 34 91 20 14 16 11 9 69
2024/20251.896 92 27 140 105 39 131 258 134 105 109 256 500
2025/20262.861 513 417 936 473 458 64 0 0 0 0 0 0
Totale 11.508