IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 6.832
EU - Europa 3.198
AS - Asia 2.693
SA - Sud America 659
AF - Africa 104
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 5
Totale 13.496
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Nazione #
US - Stati Uniti d'America 6.707
SG - Singapore 1.000
IT - Italia 792
DE - Germania 715
CN - Cina 651
BR - Brasile 527
RU - Federazione Russa 414
SE - Svezia 412
HK - Hong Kong 325
GB - Regno Unito 258
VN - Vietnam 237
FI - Finlandia 162
FR - Francia 133
IN - India 78
UA - Ucraina 64
CA - Canada 62
BD - Bangladesh 57
ID - Indonesia 53
AR - Argentina 50
JP - Giappone 49
IQ - Iraq 38
BE - Belgio 34
PK - Pakistan 33
NL - Olanda 32
PL - Polonia 32
MX - Messico 30
AT - Austria 28
ES - Italia 25
CI - Costa d'Avorio 23
IE - Irlanda 23
ZA - Sudafrica 23
CZ - Repubblica Ceca 19
EC - Ecuador 19
CO - Colombia 18
SA - Arabia Saudita 18
KR - Corea 15
MY - Malesia 15
TR - Turchia 15
TW - Taiwan 15
MA - Marocco 14
VE - Venezuela 13
IR - Iran 12
UZ - Uzbekistan 12
CL - Cile 11
PH - Filippine 10
EG - Egitto 9
LT - Lituania 9
CR - Costa Rica 8
JO - Giordania 8
KE - Kenya 7
PY - Paraguay 7
AL - Albania 6
LB - Libano 6
PE - Perù 6
SK - Slovacchia (Repubblica Slovacca) 6
TN - Tunisia 6
AZ - Azerbaigian 5
DK - Danimarca 5
IL - Israele 5
JM - Giamaica 5
LY - Libia 5
OM - Oman 5
RO - Romania 5
AE - Emirati Arabi Uniti 4
AU - Australia 4
BO - Bolivia 4
DZ - Algeria 4
ET - Etiopia 4
KG - Kirghizistan 4
KZ - Kazakistan 4
PT - Portogallo 4
BB - Barbados 3
BG - Bulgaria 3
CH - Svizzera 3
EU - Europa 3
NP - Nepal 3
CY - Cipro 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
GT - Guatemala 2
GY - Guiana 2
HN - Honduras 2
HU - Ungheria 2
MK - Macedonia 2
MN - Mongolia 2
NI - Nicaragua 2
PS - Palestinian Territory 2
SN - Senegal 2
SY - Repubblica araba siriana 2
UY - Uruguay 2
ZW - Zimbabwe 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AM - Armenia 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BS - Bahamas 1
BT - Bhutan 1
BW - Botswana 1
DO - Repubblica Dominicana 1
Totale 13.473
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Città #
Dallas 914
Fairfield 634
Ashburn 601
Singapore 503
Woodbridge 401
Chandler 396
Houston 357
San Jose 320
Hong Kong 304
Seattle 291
Milan 275
Nyköping 270
Ann Arbor 255
Beijing 243
Wilmington 227
Cambridge 222
Bari 175
Jacksonville 148
New York 102
Lauterbourg 85
Helsinki 82
Roxbury 80
Lawrence 79
Rome 74
Los Angeles 68
Brooklyn 66
Munich 64
Nanjing 63
Council Bluffs 60
Ho Chi Minh City 60
Dong Ket 59
Boardman 56
Princeton 54
Santa Clara 49
São Paulo 48
Des Moines 45
Hanoi 41
Tokyo 40
Buffalo 39
Jakarta 35
London 35
San Diego 33
Inglewood 30
Brussels 29
Chicago 25
North Bergen 25
Columbus 24
Dublin 24
Abidjan 23
Kansas City 22
Moscow 22
Shenyang 22
Hebei 21
Baghdad 19
Frankfurt am Main 19
Jiaxing 19
Orem 18
Atlanta 17
Turin 17
Warsaw 17
Denver 16
Figino 16
Nanchang 16
Montreal 15
Turku 15
Brno 14
Johannesburg 14
Paris 14
Phoenix 14
Rio de Janeiro 14
Falkenstein 13
San Francisco 12
Stockholm 12
Boston 11
Catania 11
Chennai 11
Nuremberg 11
Tashkent 11
The Dalles 11
Tianjin 11
Toronto 11
Vienna 11
Augusta 10
Dearborn 10
Guangzhou 10
Mumbai 10
Redwood City 10
Salt Lake City 10
Amsterdam 9
Haiphong 9
Jeddah 9
Lahore 9
Mexico City 9
Shanghai 9
Buenos Aires 8
Changsha 8
Curitiba 8
Düsseldorf 8
Florence 8
Groningen 8
Totale 8.792
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.114
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 228
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 219
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 214
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 211
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 211
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 204
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 200
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 199
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 196
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 189
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 184
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 183
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 183
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 181
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 179
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 177
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 177
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 176
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 175
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 167
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 166
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 165
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 165
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 164
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 163
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 160
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 160
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 158
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 156
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 154
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 151
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 149
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 148
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 148
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 147
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 146
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 145
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 145
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 142
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 139
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 139
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 138
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 138
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 136
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 134
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 131
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 129
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 128
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 126
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 126
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 122
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 121
Is the sigma-2 receptor a histone binding protein? 119
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 119
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 118
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 118
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 118
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 118
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 117
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 116
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 115
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 114
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 112
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 112
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 109
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 109
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 107
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 102
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 101
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 99
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 96
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 92
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 84
Why PB28 Could Be a Covid 2019 Game Changer? 82
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New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 79
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 78
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 77
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 76
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 75
Small molecules and acridone derivatives as P-gp inhibitors 74
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 73
New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases 73
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 71
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 70
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PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 67
Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor 66
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 63
In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 62
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 54
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 51
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 51
Exploring Selenium-Functionalized Hydroxyapatite Using Organic Selenocystine for Antitumor Applications 44
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 40
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties 36
Totale 13.768
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Categoria #
all - tutte 51.273
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.273
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022774 38 77 17 26 46 81 46 41 69 61 113 159
2022/20231.132 183 148 71 84 142 144 11 126 171 7 20 25
2023/2024420 33 61 21 41 34 91 20 14 16 11 9 69
2024/20251.896 92 27 140 105 39 131 258 134 105 109 256 500
2025/20265.140 513 417 936 473 458 234 460 138 477 413 153 468
2026/202789 89 0 0 0 0 0 0 0 0 0 0 0
Totale 13.876