IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 4.363
EU - Europa 1.959
AS - Asia 683
SA - Sud America 9
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 7.025
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Nazione #
US - Stati Uniti d'America 4.354
DE - Germania 621
SE - Svezia 412
CN - Cina 387
IT - Italia 264
GB - Regno Unito 203
RU - Federazione Russa 203
SG - Singapore 175
FI - Finlandia 75
VN - Vietnam 64
UA - Ucraina 58
BE - Belgio 27
FR - Francia 25
IE - Irlanda 19
IN - India 18
CZ - Repubblica Ceca 14
PL - Polonia 12
IR - Iran 11
CA - Canada 8
HK - Hong Kong 8
NL - Olanda 7
JP - Giappone 5
RO - Romania 5
TR - Turchia 4
EU - Europa 3
ID - Indonesia 3
LT - Lituania 3
LY - Libia 3
PE - Perù 3
AU - Australia 2
BR - Brasile 2
CH - Svizzera 2
CL - Cile 2
ES - Italia 2
GE - Georgia 2
IL - Israele 2
KZ - Kazakistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
CO - Colombia 1
KG - Kirghizistan 1
LU - Lussemburgo 1
LV - Lettonia 1
MX - Messico 1
MY - Malesia 1
NG - Nigeria 1
PT - Portogallo 1
SK - Slovacchia (Repubblica Slovacca) 1
ZW - Zimbabwe 1
Totale 7.025
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Città #
Fairfield 634
Chandler 411
Woodbridge 400
Houston 348
Ashburn 316
Seattle 288
Nyköping 282
Ann Arbor 255
Wilmington 225
Cambridge 222
Bari 159
Jacksonville 146
Singapore 143
Beijing 95
Lawrence 83
Roxbury 80
New York 73
Nanjing 63
Dong Ket 59
Princeton 54
Boardman 46
Des Moines 44
Brooklyn 42
San Diego 32
Inglewood 30
Brussels 25
London 22
Hebei 21
Shenyang 21
Kansas City 20
Munich 20
Dublin 19
Jiaxing 19
Nanchang 16
Brno 14
Guangzhou 13
Los Angeles 13
Paris 13
Rome 13
Santa Clara 12
Dearborn 10
Helsinki 10
Tianjin 10
Redwood City 9
Shanghai 9
Augusta 8
Changsha 8
Leawood 8
San Mateo 8
Ardabil 7
Catania 7
Monmouth Junction 6
Pune 6
Wuhan 6
Boydton 5
Gmina Zabierzów 5
Hefei 5
Jinan 5
Marseille 5
Ningbo 5
Romola 5
Sannicandro di Bari 5
Toronto 5
Hanoi 4
Hanover 4
Milan 4
Norwalk 4
San Francisco 4
West Jordan 4
Bitonto 3
Bologna 3
Falls Church 3
Frankfurt am Main 3
Grafing 3
Hong Kong 3
Hounslow 3
Indiana 3
Jinhua 3
Kilburn 3
Lima 3
Marlborough 3
Quanzhou 3
Taizhou 3
Acton 2
Amsterdam 2
Bergamo 2
Bucharest 2
Bąków 2
Chiswick 2
Edinburgh 2
Falkenstein 2
Istanbul 2
Krakow 2
Madrid 2
Mumbai 2
Nuremberg 2
Ottawa 2
Philadelphia 2
Sabz 2
St Albans 2
Totale 5.048
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 227
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 153
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 152
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 150
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 137
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 134
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 134
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 133
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 129
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 129
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 125
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 125
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 123
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 118
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 116
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 113
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 111
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 111
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 110
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 109
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 108
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 105
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 103
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 101
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 101
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 99
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 99
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 98
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 98
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 98
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 97
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 96
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 95
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 95
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 93
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 91
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 90
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 88
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 88
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 88
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 87
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 86
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 86
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 84
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 83
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 83
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 82
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The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 79
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 79
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 79
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Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 79
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 78
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 77
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 77
Is the sigma-2 receptor a histone binding protein? 76
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 75
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 74
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 71
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Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 67
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 66
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 65
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 53
Why PB28 Could Be a Covid 2019 Game Changer? 45
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 44
Small molecules and acridone derivatives as P-gp inhibitors 40
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 38
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 37
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 36
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 35
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 34
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 33
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 25
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 22
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 21
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 19
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 19
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 19
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 18
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 18
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 18
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 17
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 17
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 17
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 17
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 16
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 13
In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 12
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Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 8
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties 7
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Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 4
Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor 3
Totale 7.346
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Categoria #
all - tutte 31.177
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.177
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020904 0 0 0 0 0 106 139 144 166 131 135 83
2020/20211.077 64 105 75 101 86 72 71 69 93 111 107 123
2021/2022774 38 77 17 26 46 81 46 41 69 61 113 159
2022/20231.169 189 155 75 86 145 149 11 131 175 7 21 25
2023/2024443 33 65 21 44 35 101 20 14 16 11 9 74
2024/2025540 96 27 140 112 42 123 0 0 0 0 0 0
Totale 7.351