IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 4.293
EU - Europa 1.821
AS - Asia 497
SA - Sud America 9
AF - Africa 4
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 6.630
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Nazione #
US - Stati Uniti d'America 4.290
DE - Germania 604
SE - Svezia 415
CN - Cina 367
IT - Italia 235
GB - Regno Unito 199
RU - Federazione Russa 129
FI - Finlandia 71
VN - Vietnam 63
UA - Ucraina 58
BE - Belgio 26
FR - Francia 24
IE - Irlanda 19
IN - India 18
CZ - Repubblica Ceca 14
SG - Singapore 14
IR - Iran 11
PL - Polonia 10
HK - Hong Kong 5
JP - Giappone 5
RO - Romania 5
NL - Olanda 4
TR - Turchia 4
EU - Europa 3
ID - Indonesia 3
LY - Libia 3
PE - Perù 3
AU - Australia 2
BR - Brasile 2
CA - Canada 2
CH - Svizzera 2
CL - Cile 2
ES - Italia 2
GE - Georgia 2
IL - Israele 2
KZ - Kazakistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AR - Argentina 1
AT - Austria 1
BG - Bulgaria 1
CO - Colombia 1
LV - Lettonia 1
MX - Messico 1
MY - Malesia 1
PT - Portogallo 1
ZW - Zimbabwe 1
Totale 6.630
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Città #
Fairfield 634
Chandler 420
Woodbridge 400
Houston 348
Ashburn 315
Seattle 288
Nyköping 285
Ann Arbor 255
Wilmington 225
Cambridge 222
Bari 157
Jacksonville 146
Beijing 95
Lawrence 84
Roxbury 80
New York 73
Nanjing 63
Dong Ket 59
Princeton 54
Des Moines 44
Boardman 42
Brooklyn 42
San Diego 32
Inglewood 30
Brussels 24
Hebei 21
Shenyang 21
Kansas City 20
London 20
Dublin 19
Jiaxing 19
Nanchang 16
Brno 14
Guangzhou 13
Paris 13
Dearborn 10
Singapore 10
Tianjin 10
Redwood City 9
Shanghai 9
Augusta 8
Leawood 8
San Mateo 8
Ardabil 7
Changsha 7
Los Angeles 7
Helsinki 6
Monmouth Junction 6
Pune 6
Rome 6
Wuhan 6
Boydton 5
Catania 5
Gmina Zabierzów 5
Hefei 5
Jinan 5
Marseille 5
Munich 5
Ningbo 5
Sannicandro di Bari 5
Hanoi 4
Hanover 4
Milan 4
Norwalk 4
San Francisco 4
West Jordan 4
Bitonto 3
Bologna 3
Falls Church 3
Grafing 3
Hounslow 3
Indiana 3
Jinhua 3
Kilburn 3
Lima 3
Quanzhou 3
Taizhou 3
Acton 2
Bergamo 2
Bucharest 2
Bąków 2
Chiswick 2
Edinburgh 2
Frankfurt am Main 2
Istanbul 2
Krakow 2
Madrid 2
Mumbai 2
Sabz 2
St Albans 2
Strasbourg 2
Tel Aviv 2
Waanrode 2
Washington 2
Wuxi 2
Yiwu 2
Acquaviva delle Fonti 1
Almaty 1
Biella 1
Bogotá 1
Totale 4.860
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 216
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 148
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 144
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 142
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 130
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 129
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 128
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 128
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 125
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 124
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 122
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 120
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 116
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 113
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 110
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 108
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 107
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 107
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 105
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 105
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 104
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 103
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 100
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 99
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 97
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 96
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 94
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 94
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 93
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 93
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 93
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 92
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 91
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 91
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 90
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 86
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 86
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 85
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 84
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 83
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 83
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 83
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 83
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 80
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A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 80
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 80
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 78
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 78
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The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 77
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 77
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 74
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 74
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 74
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 74
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 73
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 72
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 71
Is the sigma-2 receptor a histone binding protein? 71
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 70
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Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 65
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 64
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 64
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 49
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 48
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 40
Small molecules and acridone derivatives as P-gp inhibitors 37
Why PB28 Could Be a Covid 2019 Game Changer? 37
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 34
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 33
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 32
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 29
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 28
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 25
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 23
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 20
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 20
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 18
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 18
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 16
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Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 15
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 14
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 13
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 12
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 11
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 9
In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 9
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 8
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 8
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 6
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties 4
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 4
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Totale 6.902
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Categoria #
all - tutte 27.093
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.093
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.570 226 59 84 151 146 106 139 144 166 131 135 83
2020/20211.077 64 105 75 101 86 72 71 69 93 111 107 123
2021/2022774 38 77 17 26 46 81 46 41 69 61 113 159
2022/20231.187 190 157 76 87 146 153 11 135 176 7 22 27
2023/2024448 33 65 21 44 36 102 20 16 16 11 9 75
2024/202571 71 0 0 0 0 0 0 0 0 0 0 0
Totale 6.905