IRIS
NISO, MAURO
 Distribuzione geografica
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Continente #
NA - Nord America 8.206
EU - Europa 3.377
AS - Asia 2.747
SA - Sud America 688
Continente sconosciuto - Info sul continente non disponibili 392
AF - Africa 107
OC - Oceania 6
Totale 15.523
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Nazione #
US - Stati Uniti d'America 7.963
SG - Singapore 1.008
IT - Italia 900
DE - Germania 719
CN - Cina 657
BR - Brasile 544
RU - Federazione Russa 433
SE - Svezia 414
HK - Hong Kong 328
GB - Regno Unito 274
VN - Vietnam 239
FI - Finlandia 162
FR - Francia 137
CA - Canada 107
IN - India 78
BD - Bangladesh 75
UA - Ucraina 64
ID - Indonesia 55
AR - Argentina 50
JP - Giappone 49
IQ - Iraq 38
BE - Belgio 34
PL - Polonia 34
NL - Olanda 33
PK - Pakistan 33
MX - Messico 31
AT - Austria 28
ES - Italia 26
EC - Ecuador 25
CI - Costa d'Avorio 23
IE - Irlanda 23
LT - Lituania 23
ZA - Sudafrica 23
CO - Colombia 22
SA - Arabia Saudita 21
CZ - Repubblica Ceca 19
MY - Malesia 16
TR - Turchia 16
KR - Corea 15
TW - Taiwan 15
VE - Venezuela 15
MA - Marocco 14
CR - Costa Rica 13
JM - Giamaica 13
IR - Iran 12
PH - Filippine 12
SV - El Salvador 12
UZ - Uzbekistan 12
CL - Cile 11
DK - Danimarca 10
IL - Israele 10
EG - Egitto 9
GT - Guatemala 9
HN - Honduras 9
TT - Trinidad e Tobago 9
GP - Guadalupe 8
JO - Giordania 8
PR - Porto Rico 8
KE - Kenya 7
NI - Nicaragua 7
PY - Paraguay 7
AL - Albania 6
LB - Libano 6
PE - Perù 6
SK - Slovacchia (Repubblica Slovacca) 6
TN - Tunisia 6
AZ - Azerbaigian 5
CW - ???statistics.table.value.countryCode.CW??? 5
LY - Libia 5
OM - Oman 5
RO - Romania 5
AE - Emirati Arabi Uniti 4
AU - Australia 4
BO - Bolivia 4
DZ - Algeria 4
EE - Estonia 4
ET - Etiopia 4
KG - Kirghizistan 4
KZ - Kazakistan 4
PT - Portogallo 4
BB - Barbados 3
BG - Bulgaria 3
CH - Svizzera 3
EU - Europa 3
NP - Nepal 3
SC - Seychelles 3
TH - Thailandia 3
AM - Armenia 2
BS - Bahamas 2
CY - Cipro 2
GD - Grenada 2
GE - Georgia 2
GR - Grecia 2
GY - Guiana 2
HT - Haiti 2
HU - Ungheria 2
LC - Santa Lucia 2
MK - Macedonia 2
MN - Mongolia 2
PS - Palestinian Territory 2
Totale 15.107
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Città #
Dallas 921
Ashburn 698
Fairfield 634
Singapore 505
San Jose 460
Los Angeles 443
Woodbridge 401
Chandler 396
Houston 359
Hong Kong 307
Seattle 293
Milan 282
Nyköping 270
Ann Arbor 255
Beijing 247
Wilmington 227
Cambridge 222
Council Bluffs 187
Bari 176
Jacksonville 150
New York 125
Rome 87
Lauterbourg 85
Helsinki 82
Roxbury 80
Lawrence 79
Boardman 77
Santa Clara 76
Brooklyn 68
Munich 64
Nanjing 63
Ho Chi Minh City 60
São Paulo 60
Dong Ket 59
Princeton 54
Des Moines 46
Buffalo 42
Hanoi 41
Tokyo 40
North Bergen 38
Jakarta 35
London 35
San Diego 35
Chicago 31
Inglewood 30
Brussels 29
Phoenix 29
Columbus 27
Dublin 24
Kansas City 24
Abidjan 23
Moscow 22
Shenyang 22
Atlanta 21
Hebei 21
Turin 21
Naples 20
Washington 20
Baghdad 19
Frankfurt am Main 19
Jiaxing 19
Orem 19
Toronto 19
Montreal 18
Warsaw 18
Denver 17
Figino 17
Nanchang 16
Rio de Janeiro 15
Turku 15
Vilnius 15
Brno 14
Johannesburg 14
Paris 14
Boston 13
Falkenstein 13
Nuremberg 13
San Francisco 13
The Dalles 13
Florence 12
Stockholm 12
Catania 11
Chennai 11
Jeddah 11
San Salvador 11
Tashkent 11
Tianjin 11
Vienna 11
Augusta 10
Dearborn 10
Guangzhou 10
Kingston 10
Mumbai 10
Redwood City 10
Salt Lake City 10
San José 10
Amsterdam 9
Bologna 9
Brasília 9
Haiphong 9
Totale 9.778
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.141
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 262
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 235
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 235
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 233
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 226
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 221
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 221
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 219
4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes 218
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 214
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 209
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 207
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 205
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 203
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 202
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 200
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 196
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 194
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 192
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 191
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 189
Is the sigma-2 receptor a histone binding protein? 188
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 187
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 187
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 187
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 187
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 185
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 181
F281, synthetic agonist of the sigma-2 receptor, induces Ca2+ efflux from the endoplasmic reticulum and mitochondria in SK-N-SH cells 176
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 175
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 173
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 170
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 170
The interaction of celecoxib with MDR transporters enhances the activity of mitomycin C in a bladder cancer cell line 168
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 166
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 163
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 161
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 161
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 160
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 157
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 157
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 156
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 155
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 155
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 155
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 152
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 151
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 146
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 140
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 139
The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists 136
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 136
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 135
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 134
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 129
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 127
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 126
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 126
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 125
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 125
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 125
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 124
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 124
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 123
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 122
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 121
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 120
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 120
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 119
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 119
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 116
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 113
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 107
A Benzopyrane Derivative as a P-Glycoprotein Stimulator: A Potential Agent to Decrease β-Amyloid Accumulation in Alzheimer's Disease 102
Why PB28 Could Be a Covid 2019 Game Changer? 93
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 92
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 91
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 90
New oxaliplatin-zoledronate derivatives with potential antitumor activity towards bone tumors and metastases 90
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 88
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 87
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 85
DESIGN SYNTHESIS AND BIOLOGYCAL ACTIVITY OF NEW POTENT GALLOYL-BASED MRP1 INHIBITORS FOR REVERSING MDR 83
Small molecules and acridone derivatives as P-gp inhibitors 80
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 80
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In Vitro and in Silico Analysis of the Residence Time of Serotonin 5-HT7Receptor Ligands with Arylpiperazine Structure: A Structure-Kinetics Relationship Study 79
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 79
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 78
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agent 70
Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor 70
Knowledge-Based Design of Long-Chain Arylpiperazine Derivatives Targeting Multiple Serotonin Receptors as Potential Candidates for Treatment of Autism Spectrum Disorder 69
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In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 65
Exploring Selenium-Functionalized Hydroxyapatite Using Organic Selenocystine for Antitumor Applications 58
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 56
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 53
Development of dual acting selenium-doped hydroxyapatite nanoparticles with platinum-bisphosphonate complexes for bone cancer therapy 51
Totale 15.289
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Categoria #
all - tutte 56.252
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 56.252
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022616 0 0 0 0 46 81 46 41 69 61 113 159
2022/20231.132 183 148 71 84 142 144 11 126 171 7 20 25
2023/2024420 33 61 21 41 34 91 20 14 16 11 9 69
2024/20251.896 92 27 140 105 39 131 258 134 105 109 256 500
2025/20265.140 513 417 936 473 458 234 460 138 477 413 153 468
2026/20271.736 485 272 323 591 65 0 0 0 0 0 0 0
Totale 15.523