IRIS
FRANCHINI, Carlo
 Distribuzione geografica
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Continente #
NA - Nord America 15.195
AS - Asia 4.800
EU - Europa 3.887
SA - Sud America 1.111
AF - Africa 189
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 6
Totale 25.203
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Nazione #
US - Stati Uniti d'America 15.061
SG - Singapore 1.962
CN - Cina 1.335
BR - Brasile 967
SE - Svezia 775
IT - Italia 714
HK - Hong Kong 677
RU - Federazione Russa 507
UA - Ucraina 447
DE - Germania 435
VN - Vietnam 358
FI - Finlandia 286
GB - Regno Unito 282
FR - Francia 133
CI - Costa d'Avorio 104
IN - India 99
ID - Indonesia 64
CA - Canada 58
AR - Argentina 56
IE - Irlanda 50
MX - Messico 50
BD - Bangladesh 48
JP - Giappone 46
NL - Olanda 43
BE - Belgio 40
PL - Polonia 39
IQ - Iraq 34
ZA - Sudafrica 33
TR - Turchia 30
ES - Italia 29
IR - Iran 22
CO - Colombia 20
PK - Pakistan 19
LT - Lituania 17
VE - Venezuela 17
MA - Marocco 15
SA - Arabia Saudita 14
AU - Australia 13
KR - Corea 12
PE - Perù 12
UZ - Uzbekistan 12
AT - Austria 11
CL - Cile 11
CZ - Repubblica Ceca 11
EC - Ecuador 11
IL - Israele 10
UY - Uruguay 10
CH - Svizzera 9
RO - Romania 9
PT - Portogallo 8
RS - Serbia 8
AE - Emirati Arabi Uniti 7
DZ - Algeria 7
LV - Lettonia 7
EG - Egitto 6
KE - Kenya 6
MY - Malesia 6
TN - Tunisia 6
TT - Trinidad e Tobago 6
EE - Estonia 5
EU - Europa 5
HU - Ungheria 5
OM - Oman 5
PY - Paraguay 5
CR - Costa Rica 4
DK - Danimarca 4
NG - Nigeria 4
PH - Filippine 4
AM - Armenia 3
GT - Guatemala 3
HR - Croazia 3
JM - Giamaica 3
JO - Giordania 3
KG - Kirghizistan 3
KW - Kuwait 3
KZ - Kazakistan 3
LB - Libano 3
LU - Lussemburgo 3
SN - Senegal 3
AL - Albania 2
AO - Angola 2
AZ - Azerbaigian 2
BH - Bahrain 2
BO - Bolivia 2
DO - Repubblica Dominicana 2
ET - Etiopia 2
GE - Georgia 2
HN - Honduras 2
KH - Cambogia 2
NP - Nepal 2
PA - Panama 2
PS - Palestinian Territory 2
SY - Repubblica araba siriana 2
TH - Thailandia 2
BG - Bulgaria 1
BS - Bahamas 1
BY - Bielorussia 1
CY - Cipro 1
DM - Dominica 1
GR - Grecia 1
Totale 25.194
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Città #
Dallas 2.638
Fairfield 1.425
Ashburn 1.119
Chandler 1.092
Jacksonville 991
Woodbridge 971
Singapore 962
Houston 802
Hong Kong 669
Seattle 551
Nyköping 536
Cambridge 516
Wilmington 499
Ann Arbor 423
Beijing 309
Lawrence 262
Roxbury 260
Bari 256
Nanjing 227
New York 224
Los Angeles 189
Dong Ket 168
Boardman 165
Des Moines 162
Princeton 151
Brooklyn 104
Abidjan 103
San Diego 87
São Paulo 84
Munich 72
Ho Chi Minh City 71
Nanchang 67
Santa Clara 66
Jiaxing 64
Buffalo 61
Hebei 61
Shenyang 61
Inglewood 59
Dublin 46
Hanoi 45
London 43
Moscow 43
Rome 43
Tianjin 43
Dearborn 40
Brussels 39
Tokyo 38
Jakarta 36
Redwood City 35
Rio de Janeiro 34
Warsaw 34
North Bergen 31
Guangzhou 30
Helsinki 30
Pune 30
Chicago 28
Falls Church 28
Paris 28
Marseille 27
Milan 26
Turku 26
San Francisco 24
Changsha 23
Belo Horizonte 22
Brasília 22
Leawood 22
Shanghai 22
Amsterdam 21
Council Bluffs 21
Phoenix 21
Denver 20
Jinan 20
San Mateo 20
Stockholm 19
Atlanta 18
Wuhan 18
Frankfurt am Main 17
Johannesburg 17
Toronto 17
Montreal 16
Porto Alegre 16
Chennai 15
Hefei 15
Washington 15
Ardabil 14
Mumbai 14
Boston 13
Kansas City 13
Norwalk 13
The Dalles 13
Augusta 12
Dhaka 12
Nuremberg 12
Taizhou 12
West Jordan 12
Zhengzhou 12
Auburn Hills 11
Baghdad 11
Campinas 11
Mexico City 11
Totale 17.967
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Nome #
1, 3‐Benzothiazoles as Antimicrobial Agents 1.083
1,3-Benzothiazoles as Antimicrobial Agents 1.067
1,3-Benzothiazole derivatives: design, synthesis and evaluation of their antimicrobial activity 972
Bovine and soybean milk bioactive compounds: Effects on inflammatory response of human intestinal Caco-2 cells 210
4H-1,4-benzothiazine, dihydro-1,4-benzothiazinones and 2-amino-5- fluorobenzenethiol derivatives: Design, synthesis and in vitro antimicrobial screening 192
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 189
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma 188
Effects of sweet cherry polyphenols on enhanced osteoclastogenesis associated with childhood obesity 187
2-Aminobenzothiazole derivatives: Search for new antifungal agents 176
1-Pentanoyl-N-{[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide: Investigation of Structural Variations 175
POLYPHENO srl - Spin Off Accademica Accreditata del''Università degli Studi di Bari "Aldo Moro" 167
Apixaban: Effective And Safe In Preventing Thromboembolic Events In Patients With Atrial Fibrillation And Renal Failure. 165
Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives 163
Fitocomplesso polifenolico standardizzato per la prevenzione delle patologie correlate all’esposizione da sostanze reattive dell’ossigeno e relativo metodo di produzione 163
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 162
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 161
A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells 161
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 158
A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues 155
2,6-xilididi e b-2,6,-xililossietilammine come ligandi anfipatici per i recettori benzodiazepinici di tipo mitocondriale 151
Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents 151
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs 151
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 150
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites 148
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II 146
Biological evaluation of Hyperforin and its Hydrogenated analogue on bacterial growth and biofilm production 141
2-Arylazetidines as ligands for nicotinic acetylcholine receptors 141
Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos 140
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II 139
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 137
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 137
1-Peptidyl-2-Haloacetylhydrazines as substrate analogue inhibitors toward Cathepsin B and Calpains 135
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite 135
Effect of Methyl -β- Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles 135
Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens 135
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers 134
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 134
In vitro interactions between anidulafungin and nonsteroidal anti-inflammatory drugs on biofilms of Candida spp 133
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 132
Chemical composition and antibacterial activity of seven uncommon essential oils 131
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 129
The practice of medicinal chemistry 126
Facile entry to (-)-R- and (+)-(S)-mexiletine 126
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 125
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 124
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 123
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 121
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 121
Organofluorinecontaining anti-infective agents 121
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition 119
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 118
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 118
Pharmacological differences between R(-) and S(+) Tocainide 117
In vitro and ex vivo studies on Diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment 116
Pharmacological differences between R(-) and S(+) Tocainide 112
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones 112
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 111
Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate 111
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 110
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 110
AT1 receptor ligands: virtual screening based design with TOPP descriptors, synthesis and biological evaluation of pyrrolidine derivatives 109
Activity of natural hydroxytyrosol versus a synthetic sample and its chiral analogues: hypotesis on mechanism of action 109
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 108
Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors 108
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 107
alpha-Glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 107
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 106
Applicazione di un disegno sperimentale alla sintesi enantiospecifica one-step dell’acido O-fenilmandelico, utile agente di solvatazione chirale 105
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors 105
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate 104
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 104
Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination 103
Dry powder formulations from olive oil wastewater with high nutraceutical properties 103
Novel insights in health-promoting properties of sweet cherries 103
Stereospecific synthesis and absolute configuration of Mexiletine 102
Analisi di Horeau modificata: applicazione ad acidi alpha-arilossialcanoici ed isosteri omochirali 102
Calmodulin-Dependent Kinase II Mediates Vascular Smooth Muscle Cell Proliferation and Is Potentiated by Extracellular Signal Regulated Kinase 102
Synthesis and Biological Evaluation of 2-Mercapto-1,3-benzothiazole Derivatives with Potential Antimicrobial Activity 101
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 101
Effects of mexiletine on ATP sensitive K+ channel of rat skeletal muscle fibres: a state dependent mechanism of action 100
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 100
Toxicological profiles of chemicals in soil 100
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 98
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 98
Enhanced solubility and antibacterial activity of lipophilic fluoro-substituted N-benzoyl-2-aminobenzothiazoles by complexation with beta-cyclodextrins 98
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction 98
Synthesis and inhibiting activities of 1-peptidyl-2-haloacetyl hydrazines toward cathepsin B and calpains 97
Analoghi chirali della Tocainide: attività analgesica centrale 96
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 96
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents 96
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 95
Synthesis of new phenylpyridyl scaffolds using the Garlanding approach 95
Stereospecific effects of tocainide and its chiral derivatives on rat skeletal muscle sodium channel. 95
Antimyotonic effects of enantiomers of mexiletine-like drugs 95
Species-dependent binding of tocainide analogues to albumin: Affinity chromatography and circular dichroism study 95
Lubeluzole: from anti-ischemic to chemosensitizing agent 94
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 92
Analoghi rigidi della Tocainide: 2',6'-Prolinoxilidide e suoi derivati 92
N-(2,6-Xylil) piperazine and piperidine carboxamides as new antimyotonic agents 92
Activity of natural hydroxytyrosol versus a synthestic sample and its chiral analogues: hypothesis of mechanism of action 92
Totale 15.203
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Categoria #
all - tutte 104.415
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 104.415
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.608 0 0 0 0 0 115 211 135 267 355 225 300
2021/20222.000 95 341 22 70 85 129 134 82 140 128 291 483
2022/20233.008 494 280 164 276 399 415 32 297 494 27 56 74
2023/20241.162 94 191 51 90 57 264 38 65 39 50 89 134
2024/20253.893 139 84 392 154 82 296 269 359 209 193 546 1.170
2025/20266.429 1.116 778 2.543 973 842 177 0 0 0 0 0 0
Totale 25.825