llypcrtbrin ir a natural phloroglucinol tlraî hao baen knswn for îhe trc6lm{:!î of dsprer'niop. llyperforin clisplay* alro antibacr€rial. antiprolifcranr and ontiangiogenic activity. Synrhetie dsrivatives ofhypcrlnrin have also recsfltly been reportsd lo porisc$j incrcared bioactivity. The clinicnl applicttiols arE lirnitcd by tlre hydrophobie characteristics and the irstability nfthc molecule, In this rcview wc diserss abqut somc of thc dcrivrtive$ of hyperforin (nrirtoforin, tetrohydrohyperfbrin onil octalrydrohperlbrin) that dcmonsrratcd promising antitunror uetivity. Anrong the${], octahyrJrohyper{orin alsn pa$set$cf antibsdîsrial aqtivity 4Baif|rit both the planktonic and biofilm saatc$ ofbact$ria.
Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives
ROSATO, Antonio;Muraglia Marilena;FRANCHINI, Carlo;CORBO, Filomena Faustina Rina
2014-01-01
Abstract
llypcrtbrin ir a natural phloroglucinol tlraî hao baen knswn for îhe trc6lm{:!î of dsprer'niop. llyperforin clisplay* alro antibacr€rial. antiprolifcranr and ontiangiogenic activity. Synrhetie dsrivatives ofhypcrlnrin have also recsfltly been reportsd lo porisc$j incrcared bioactivity. The clinicnl applicttiols arE lirnitcd by tlre hydrophobie characteristics and the irstability nfthc molecule, In this rcview wc diserss abqut somc of thc dcrivrtive$ of hyperforin (nrirtoforin, tetrohydrohyperfbrin onil octalrydrohperlbrin) that dcmonsrratcd promising antitunror uetivity. Anrong the${], octahyrJrohyper{orin alsn pa$set$cf antibsdîsrial aqtivity 4Baif|rit both the planktonic and biofilm saatc$ ofbact$ria.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
