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EnglishThe title compounds, 1a and 1b, have been synthesized in a three-step sequence starting from (-)-(S) and (+)-(R)-propylene oxide, respectively, in acceptable overall yields. The enantiomeric excess values for 1a and 1b were 96% and 93% respectively, as assessed by HPLC analysis on a chiral stationary phase of the corresponding N-acetyl derivatives. The synthetic route herein presented may represent a facile entry to highly enriched mexiletine enantiomers, alternative to those previously reported in the literature.
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| Titolo: | Facile entry to (-)-R- and (+)-(S)-mexiletine |
| Autori: | |
| Data di pubblicazione: | 2000 |
| Rivista: | |
| Citazione: | Facile entry to (-)-R- and (+)-(S)-mexiletine / CAROCCI A.; FRANCHINI C.; LENTINI G; LOIODICE F.; TORTORELLA V.. - In: CHIRALITY. - ISSN 0899-0042. - 12:3(2000), pp. 103-106. |
| Abstract: | The title compounds, 1a and 1b, have been synthesized in a three-step sequence starting from (-)-(S) and (+)-(R)-propylene oxide, respectively, in acceptable overall yields. The enantiomeric excess values for 1a and 1b were 96% and 93% respectively, as assessed by HPLC analysis on a chiral stationary phase of the corresponding N-acetyl derivatives. The synthetic route herein presented may represent a facile entry to highly enriched mexiletine enantiomers, alternative to those previously reported in the literature. |
| Handle: | http://hdl.handle.net/11586/132471 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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