The title compounds, 1a and 1b, have been synthesized in a three-step sequence starting from (-)-(S) and (+)-(R)-propylene oxide, respectively, in acceptable overall yields. The enantiomeric excess values for 1a and 1b were 96% and 93% respectively, as assessed by HPLC analysis on a chiral stationary phase of the corresponding N-acetyl derivatives. The synthetic route herein presented may represent a facile entry to highly enriched mexiletine enantiomers, alternative to those previously reported in the literature.

Facile entry to (-)-R- and (+)-(S)-mexiletine

CAROCCI, ALESSIA;FRANCHINI, Carlo;LENTINI, Giovanni;LOIODICE, Fulvio;
2000

Abstract

The title compounds, 1a and 1b, have been synthesized in a three-step sequence starting from (-)-(S) and (+)-(R)-propylene oxide, respectively, in acceptable overall yields. The enantiomeric excess values for 1a and 1b were 96% and 93% respectively, as assessed by HPLC analysis on a chiral stationary phase of the corresponding N-acetyl derivatives. The synthetic route herein presented may represent a facile entry to highly enriched mexiletine enantiomers, alternative to those previously reported in the literature.
File in questo prodotto:
File Dimensione Formato  
chirality 2000.pdf

non disponibili

Licenza: NON PUBBLICO - Accesso privato/ristretto
106.76 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11586/132471
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 30
social impact