| Nome |
# |
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A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma, file dd9e0c6c-8f15-1e9c-e053-3a05fe0a45ef
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228
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Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination, file dd9e0c64-1ac7-1e9c-e053-3a05fe0a45ef
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207
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Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II, file dd9e0c67-c9bf-1e9c-e053-3a05fe0a45ef
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161
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Bovine and soybean milk bioactive compounds: Effects on inflammatory response of human intestinal Caco-2 cells, file dd9e0c6b-9066-1e9c-e053-3a05fe0a45ef
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103
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Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity, file dd9e0c63-ad32-1e9c-e053-3a05fe0a45ef
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100
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In vitro and ex vivo studies on Diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment, file 3a496748-817c-481c-be6c-7e6d075391bb
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86
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Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos, file dd9e0c65-d89d-1e9c-e053-3a05fe0a45ef
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84
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Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials, file dd9e0c65-b956-1e9c-e053-3a05fe0a45ef
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74
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Effects of sweet cherry polyphenols on enhanced osteoclastogenesis associated with childhood obesity, file dd9e0c65-a3c3-1e9c-e053-3a05fe0a45ef
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72
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Bovine and soybean milk bioactive compounds: Effects on inflammatory response of human intestinal Caco-2 cells, file 05730b94-4f18-4be7-b42c-1f8ce673fd0c
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62
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Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition, file dd9e0c64-931f-1e9c-e053-3a05fe0a45ef
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62
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Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres, file dd9e0c62-a22c-1e9c-e053-3a05fe0a45ef
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56
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Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens, file dd9e0c66-bef8-1e9c-e053-3a05fe0a45ef
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54
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Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency, file aefc2a7a-5a3e-455c-81ec-9f7d0d9ccea9
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51
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Bovine and soybean milk bioactive compounds: Effects on inflammatory response of human intestinal Caco-2 cells, file dd9e0c63-7a70-1e9c-e053-3a05fe0a45ef
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45
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Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers, file dd9e0c63-e8ee-1e9c-e053-3a05fe0a45ef
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42
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Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives, file dd9e0c69-e17c-1e9c-e053-3a05fe0a45ef
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37
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Effect of Methyl -β- Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles, file dd9e0c6c-7f45-1e9c-e053-3a05fe0a45ef
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34
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In vitro interactions between anidulafungin and nonsteroidal anti-inflammatory drugs on biofilms of Candida spp, file dd9e0c6c-84db-1e9c-e053-3a05fe0a45ef
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24
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Synthesis and antimicrobial evaluation of a new series of N-1,3-benzothiazol-2-ylbenzamides, file dd9e0c63-0217-1e9c-e053-3a05fe0a45ef
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17
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Effect of Methyl -β- Cyclodextrin on the antimicrobial activity of a new series of poorly water-soluble benzothiazoles, file dd9e0c65-7487-1e9c-e053-3a05fe0a45ef
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15
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Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels, file dd9e0c6b-45e6-1e9c-e053-3a05fe0a45ef
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15
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A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues, file dd9e0c67-e099-1e9c-e053-3a05fe0a45ef
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13
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Stereospecific synthesis of “para-hydroxymexiletine“ amd sodium channel blocking activity evaluation, file dd9e0c68-da76-1e9c-e053-3a05fe0a45ef
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11
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In vitro interactions between anidulafungin and nonsteroidal anti-inflammatory drugs on biofilms of Candida spp, file dd9e0c63-4ee5-1e9c-e053-3a05fe0a45ef
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10
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POLYPHENO srl - Spin Off Accademica Accreditata del''Università degli Studi di Bari "Aldo Moro", file dd9e0c69-f4a7-1e9c-e053-3a05fe0a45ef
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9
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Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c6c-84df-1e9c-e053-3a05fe0a45ef
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9
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Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules, file dd9e0c62-f60d-1e9c-e053-3a05fe0a45ef
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8
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null, file dd9e0c68-0886-1e9c-e053-3a05fe0a45ef
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8
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1, 3‐Benzothiazoles as Antimicrobial Agents, file dd9e0c62-725e-1e9c-e053-3a05fe0a45ef
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7
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Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine, file dd9e0c62-a8ed-1e9c-e053-3a05fe0a45ef
|
7
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2-Aminobenzothiazole derivatives: Search for new antifungal agents, file dd9e0c63-0210-1e9c-e053-3a05fe0a45ef
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7
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Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds, file dd9e0c68-da6a-1e9c-e053-3a05fe0a45ef
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7
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Erratum: Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels, file dd9e0c62-871f-1e9c-e053-3a05fe0a45ef
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6
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A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells, file dd9e0c63-5319-1e9c-e053-3a05fe0a45ef
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6
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Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites, file dd9e0c64-1d78-1e9c-e053-3a05fe0a45ef
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6
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|
Novel insights in health-promoting properties of sweet cherries, file dd9e0c66-8c3b-1e9c-e053-3a05fe0a45ef
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6
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Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile, file dd9e0c68-da70-1e9c-e053-3a05fe0a45ef
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6
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Searching for small molecules as antibacterials: Non-cytotoxic diarylureas analogues of triclocarban, file a4f23aab-cb0a-4039-917f-c29c67975711
|
5
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Biological evaluation of Hyperforin and its Hydrogenated analogue on bacterial growth and biofilm production, file dd9e0c63-02b3-1e9c-e053-3a05fe0a45ef
|
5
|
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Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents, file dd9e0c64-19e6-1e9c-e053-3a05fe0a45ef
|
5
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A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma, file dd9e0c64-c251-1e9c-e053-3a05fe0a45ef
|
5
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|
Chemical composition and antibacterial activity of seven uncommon essential oils, file dd9e0c64-f27a-1e9c-e053-3a05fe0a45ef
|
5
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Facile, alternative route to Lubeluzole, its enantiomer, and the racemate, file dd9e0c65-af03-1e9c-e053-3a05fe0a45ef
|
5
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|
null, file dd9e0c62-7ead-1e9c-e053-3a05fe0a45ef
|
4
|
|
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents, file dd9e0c63-020d-1e9c-e053-3a05fe0a45ef
|
4
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|
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs, file dd9e0c63-32a0-1e9c-e053-3a05fe0a45ef
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4
|
|
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II, file dd9e0c64-2a77-1e9c-e053-3a05fe0a45ef
|
4
|
|
null, file dd9e0c64-2a7d-1e9c-e053-3a05fe0a45ef
|
4
|
|
In vitro and ex vivo studies on Diltiazem hydrochloride-loaded microsponges in rectal gels for chronic anal fissures treatment, file dd9e0c65-7489-1e9c-e053-3a05fe0a45ef
|
4
|
|
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine, file dd9e0c65-b0a6-1e9c-e053-3a05fe0a45ef
|
4
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Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo, file dd9e0c65-f6d6-1e9c-e053-3a05fe0a45ef
|
4
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Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers, file dd9e0c67-cd44-1e9c-e053-3a05fe0a45ef
|
4
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First synthesis and full characterization of mexiletine N-carbonyloxy beta-D-glucuronide, file dd9e0c68-0eb7-1e9c-e053-3a05fe0a45ef
|
4
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|
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels, file dd9e0c68-fe80-1e9c-e053-3a05fe0a45ef
|
4
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Olive Tree in Circular Economy as a Source of Secondary Metabolites Active for Human and Animal Health Beyond Oxidative Stress and Inflammation, file dd9e0c6b-20a7-1e9c-e053-3a05fe0a45ef
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4
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Schiff bases: Interesting scaffolds with promising antitumoral properties, file dd9e0c6b-5e76-1e9c-e053-3a05fe0a45ef
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4
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Synthesis and biological evaluation of 3-alkyloxazolidin-2-ones as reversible MAO inhibitors, file dd9e0c63-0369-1e9c-e053-3a05fe0a45ef
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3
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|
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II, file dd9e0c63-5a60-1e9c-e053-3a05fe0a45ef
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3
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Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c63-b970-1e9c-e053-3a05fe0a45ef
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3
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|
null, file dd9e0c64-ae82-1e9c-e053-3a05fe0a45ef
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3
|
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Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods, file dd9e0c66-03c4-1e9c-e053-3a05fe0a45ef
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3
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|
1-Pentanoyl-N-{[2’-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-pyrrolidine-2-carboxamide: Investigation of Structural Variations, file dd9e0c67-c9c4-1e9c-e053-3a05fe0a45ef
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3
|
|
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels, file dd9e0c67-d164-1e9c-e053-3a05fe0a45ef
|
3
|
|
Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels, file dd9e0c67-d710-1e9c-e053-3a05fe0a45ef
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3
|
|
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents, file dd9e0c67-db72-1e9c-e053-3a05fe0a45ef
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3
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|
New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase, file dd9e0c68-2199-1e9c-e053-3a05fe0a45ef
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3
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|
Pomegranate: Nutraceutical with promising benefits on human health, file dd9e0c68-a54a-1e9c-e053-3a05fe0a45ef
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3
|
|
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities, file dd9e0c6a-ca70-1e9c-e053-3a05fe0a45ef
|
3
|
|
Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity, file dd9e0c6b-6f1b-1e9c-e053-3a05fe0a45ef
|
3
|
|
Enhanced solubility and antibacterial activity of lipophilic fluoro-substituted N-benzoyl-2-aminobenzothiazoles by complexation with beta-cyclodextrins, file dd9e0c62-d59b-1e9c-e053-3a05fe0a45ef
|
2
|
|
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency, file dd9e0c64-5522-1e9c-e053-3a05fe0a45ef
|
2
|
|
4H-1,4-benzothiazine, dihydro-1,4-benzothiazinones and 2-amino-5- fluorobenzenethiol derivatives: Design, synthesis and in vitro antimicrobial screening, file dd9e0c64-6f05-1e9c-e053-3a05fe0a45ef
|
2
|
|
null, file dd9e0c64-b45c-1e9c-e053-3a05fe0a45ef
|
2
|
|
2-Arylazetidines as ligands for nicotinic acetylcholine receptors, file dd9e0c64-e49b-1e9c-e053-3a05fe0a45ef
|
2
|
|
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity, file dd9e0c66-a4ef-1e9c-e053-3a05fe0a45ef
|
2
|
|
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity, file dd9e0c68-05e5-1e9c-e053-3a05fe0a45ef
|
2
|
|
Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents, file dd9e0c68-fe77-1e9c-e053-3a05fe0a45ef
|
2
|
|
Development, optimization, and comparison of different sample pre-treatments for simultaneous determination of vitamin e and vitamin K in vegetables, file dd9e0c6b-4045-1e9c-e053-3a05fe0a45ef
|
2
|
|
Simple thalidomide analogs in melanoma: Synthesis and biological activity, file dd9e0c6b-4a24-1e9c-e053-3a05fe0a45ef
|
2
|
|
Virgin olive oil extracts reduce oxidative stress and modulate cholesterol metabolism: Comparison between oils obtained with traditional and innovative processes, file dd9e0c6b-5007-1e9c-e053-3a05fe0a45ef
|
2
|
|
Phyllostachys Pubescens: From Traditional to Functional Food: Phyllostachys pubescens as functional food, file dd9e0c6b-8cc6-1e9c-e053-3a05fe0a45ef
|
2
|
|
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies, file dd9e0c6b-a18d-1e9c-e053-3a05fe0a45ef
|
2
|
|
Diarylureas: Repositioning from antitumor to antimicrobials or multi-target agents against new pandemics, file dd9e0c6b-d5c0-1e9c-e053-3a05fe0a45ef
|
2
|
|
Diarylureas as antitumor agents, file dd9e0c6b-e9d6-1e9c-e053-3a05fe0a45ef
|
2
|
|
Aromatic garlands, as new foldamers, to mimic protein secondary structure, file dd9e0c62-7ae0-1e9c-e053-3a05fe0a45ef
|
1
|
|
Small Molecules as MT1 And MT2 Ligands: Antioxidant Properties and in vitro Inhibition of Ca2+/CAM-Dependent Kinase II., file dd9e0c62-7f07-1e9c-e053-3a05fe0a45ef
|
1
|
|
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials, file dd9e0c62-a9c1-1e9c-e053-3a05fe0a45ef
|
1
|
|
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity, file dd9e0c63-01d6-1e9c-e053-3a05fe0a45ef
|
1
|
|
Species-dependent binding of tocainide analogues to albumin: Affinity
chromatography and circular dichroism study, file dd9e0c63-020c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Anticancer and Antibacterial Activity of Hyperforin and Its Derivatives, file dd9e0c63-021d-1e9c-e053-3a05fe0a45ef
|
1
|
|
DESIGN AND SYNTHESIS OF THIENYLPYRIDYL GARLANDS AS NON-PEPTIDIC ALPHA HELIXMIMETICS AND POTENTIAL PROTEIN-PROTEIN INTERACTIONS DISRUPTORS, file dd9e0c63-02b1-1e9c-e053-3a05fe0a45ef
|
1
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|
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity, file dd9e0c63-3345-1e9c-e053-3a05fe0a45ef
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1
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|
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite, file dd9e0c64-2a7b-1e9c-e053-3a05fe0a45ef
|
1
|
|
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide, file dd9e0c64-562b-1e9c-e053-3a05fe0a45ef
|
1
|
|
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs, file dd9e0c64-b5a7-1e9c-e053-3a05fe0a45ef
|
1
|
|
Apixaban: Effective And Safe In Preventing Thromboembolic Events In Patients With Atrial Fibrillation And Renal Failure., file dd9e0c65-ae2c-1e9c-e053-3a05fe0a45ef
|
1
|
|
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones, file dd9e0c67-c2b5-1e9c-e053-3a05fe0a45ef
|
1
|
|
Facile entry to (-)-R- and (+)-(S)-mexiletine, file dd9e0c67-c643-1e9c-e053-3a05fe0a45ef
|
1
|
|
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors, file dd9e0c67-c9c1-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
1.921 |