A series of N-1,3-benzothiazol-2-ylbenzamide derivatives were studied for their antiproliferative activity on human liver hepatocellular carcinoma (HepG2) and human breast cancer (MCF-7) cell lines. Most of them were found to show a prominent inhibitory effect on cell growth. Among the most active compounds, 1k emerged for its proapoptotic effect that is particularly evident towards MCF-7 cancer cell lines.
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers
CORBO, Filomena Faustina Rina;CAROCCI, ALESSIA;ARMENISE, Domenico;DE LAURENTIS, Nicolino;LAGHEZZA, ANTONIO;LOIODICE, Fulvio;ANCONA, PATRIZIA;MURAGLIA, MARILENA;PAGLIARULO, VINCENZO;FRANCHINI, Carlo;CATALANO, ALESSIA
2016-01-01
Abstract
A series of N-1,3-benzothiazol-2-ylbenzamide derivatives were studied for their antiproliferative activity on human liver hepatocellular carcinoma (HepG2) and human breast cancer (MCF-7) cell lines. Most of them were found to show a prominent inhibitory effect on cell growth. Among the most active compounds, 1k emerged for its proapoptotic effect that is particularly evident towards MCF-7 cancer cell lines.File in questo prodotto:
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