IRIS
PISANI, LEONARDO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 6.983
AS - Asia 2.503
EU - Europa 2.220
SA - Sud America 560
AF - Africa 88
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
AN - Antartide 1
Totale 12.362
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 6.868
SG - Singapore 916
IT - Italia 686
CN - Cina 659
BR - Brasile 440
SE - Svezia 367
HK - Hong Kong 288
RU - Federazione Russa 288
DE - Germania 239
VN - Vietnam 190
FR - Francia 153
GB - Regno Unito 133
IN - India 119
FI - Finlandia 98
UA - Ucraina 63
CA - Canada 58
ID - Indonesia 53
BD - Bangladesh 51
AR - Argentina 42
BE - Belgio 33
JP - Giappone 33
MX - Messico 32
IQ - Iraq 29
PL - Polonia 29
NL - Olanda 28
TR - Turchia 27
ZA - Sudafrica 22
IE - Irlanda 20
CI - Costa d'Avorio 19
CO - Colombia 19
EC - Ecuador 19
ES - Italia 19
IR - Iran 19
PH - Filippine 18
AT - Austria 13
VE - Venezuela 13
MA - Marocco 12
CH - Svizzera 11
CZ - Repubblica Ceca 11
KR - Corea 10
LT - Lituania 10
MY - Malesia 10
PK - Pakistan 10
SA - Arabia Saudita 10
AE - Emirati Arabi Uniti 9
TN - Tunisia 9
EG - Egitto 7
BO - Bolivia 6
CL - Cile 6
CR - Costa Rica 6
NP - Nepal 6
PE - Perù 6
PY - Paraguay 6
UZ - Uzbekistan 6
AZ - Azerbaigian 5
IL - Israele 4
JM - Giamaica 4
JO - Giordania 4
NG - Nigeria 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
TW - Taiwan 4
AU - Australia 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
KG - Kirghizistan 3
KZ - Kazakistan 3
PA - Panama 3
RS - Serbia 3
SY - Repubblica araba siriana 3
AO - Angola 2
BH - Bahrain 2
DK - Danimarca 2
EU - Europa 2
KE - Kenya 2
LB - Libano 2
NI - Nicaragua 2
RO - Romania 2
TT - Trinidad e Tobago 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AD - Andorra 1
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AQ - Antartide 1
BB - Barbados 1
BW - Botswana 1
BY - Bielorussia 1
CV - Capo Verde 1
DZ - Algeria 1
EE - Estonia 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
IS - Islanda 1
MG - Madagascar 1
MT - Malta 1
Totale 12.355
Salva come PNG Salva come JPEG
Città #
Dallas 1.011
Ashburn 656
Fairfield 645
Singapore 495
Chandler 432
Woodbridge 351
San Jose 341
Nyköping 285
Hong Kong 282
Houston 265
Seattle 258
Cambridge 235
Milan 232
Ann Arbor 219
Beijing 211
Wilmington 191
Jacksonville 130
Bari 124
New York 97
Boardman 88
Council Bluffs 86
Los Angeles 81
Roxbury 80
Lawrence 74
Lauterbourg 73
Nanjing 69
Brooklyn 51
Munich 51
Helsinki 49
Santa Clara 49
Des Moines 48
Rome 45
Ho Chi Minh City 43
São Paulo 43
Dearborn 42
Jakarta 41
San Diego 39
Dong Ket 37
North Bergen 37
Hanoi 34
Brussels 33
Falkenstein 33
Figino 32
Princeton 32
Buffalo 30
London 30
Inglewood 27
Frankfurt am Main 26
Tokyo 26
Columbus 25
Orem 23
Chicago 22
Kansas City 22
Moscow 22
Nanchang 22
Hebei 21
Marseille 21
Warsaw 21
Paris 20
Abidjan 19
Dublin 19
The Dalles 19
Atlanta 18
Montreal 18
Baghdad 16
Nuremberg 16
Johannesburg 15
Denver 14
Guangzhou 14
New Delhi 14
San Francisco 14
Turin 14
Amsterdam 13
Redwood City 13
Rio de Janeiro 13
Shenyang 13
Washington 13
Boydton 12
Shanghai 12
Toronto 12
Jiaxing 11
Wuhan 11
Chennai 10
Mumbai 10
Phoenix 10
Bologna 9
Boston 9
Changsha 9
Genoa 9
Mexico City 9
Naples 9
Norwalk 9
Poplar 9
Tianjin 9
Brasília 8
Gravina In Puglia 8
Haiphong 8
Leawood 8
Pune 8
Stockholm 8
Totale 8.600
Salva come PNG Salva come JPEG
Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.114
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 216
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 216
A rational approach to elucidate human monoamine oxidase molecular selectivity 214
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 209
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 201
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 199
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 196
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 195
Mind the Gap ! A Journey towards Computational Toxicology 194
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 193
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 189
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 189
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 183
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 179
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 178
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 177
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 172
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 171
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 166
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 165
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 165
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 162
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 161
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 160
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 148
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 148
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 143
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 142
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 139
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 138
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 138
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 137
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 133
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 131
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 127
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 124
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 122
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 122
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 120
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 118
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 115
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 115
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 114
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 113
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 113
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 112
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 111
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 108
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 106
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 106
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 104
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 102
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 101
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 99
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 99
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 98
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 97
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 96
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 96
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 94
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 94
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 89
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 88
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 88
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 87
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 85
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 85
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 82
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 82
Solid phase synthesis of potential PKs inhibitors 77
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 77
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 73
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 69
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 67
Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds 66
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 66
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 66
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 65
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 65
null 63
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 56
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 53
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 52
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors 52
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 51
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 49
A second life for MAO inhibitors: from CNS diseases to cancer 34
Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities 26
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes 9
Totale 12.745
Salva come PNG Salva come JPEG
Categoria #
all - tutte 47.213
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.213
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022775 37 115 29 12 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/20251.804 59 53 132 90 60 128 227 160 94 68 289 444
2025/20265.027 536 351 979 415 508 221 463 146 436 344 161 467
2026/202782 82 0 0 0 0 0 0 0 0 0 0 0
Totale 12.745