IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 4.144
EU - Europa 1.048
AS - Asia 504
AF - Africa 7
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 5.710
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Nazione #
US - Stati Uniti d'America 4.139
CN - Cina 368
SE - Svezia 363
IT - Italia 247
DE - Germania 125
GB - Regno Unito 78
UA - Ucraina 54
FI - Finlandia 51
FR - Francia 41
VN - Vietnam 41
SG - Singapore 33
IN - India 32
BE - Belgio 29
RU - Federazione Russa 19
IR - Iran 17
IE - Irlanda 16
NL - Olanda 10
CZ - Repubblica Ceca 6
CA - Canada 5
CH - Svizzera 4
JP - Giappone 4
MA - Marocco 3
TR - Turchia 3
EG - Egitto 2
ES - Italia 2
EU - Europa 2
HK - Hong Kong 2
NG - Nigeria 2
AD - Andorra 1
BR - Brasile 1
CL - Cile 1
CO - Colombia 1
EC - Ecuador 1
IL - Israele 1
IS - Islanda 1
KR - Corea 1
NP - Nepal 1
PE - Perù 1
PL - Polonia 1
TW - Taiwan 1
Totale 5.710
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Città #
Fairfield 645
Chandler 437
Ashburn 358
Woodbridge 351
Nyköping 292
Houston 258
Seattle 251
Cambridge 234
Ann Arbor 219
Wilmington 190
Jacksonville 129
Bari 117
Roxbury 80
Lawrence 75
Beijing 71
Nanjing 69
Boardman 65
Des Moines 47
New York 43
Dearborn 42
Dong Ket 37
San Diego 37
Brooklyn 36
Princeton 31
Brussels 29
Inglewood 27
Milan 23
Nanchang 22
Hebei 21
Singapore 21
Los Angeles 20
Kansas City 19
Marseille 19
Munich 17
Dublin 16
London 15
Paris 13
Redwood City 13
Washington 13
Guangzhou 12
Shenyang 12
Boydton 10
Jiaxing 10
Changsha 9
Norwalk 9
Tianjin 9
Gravina In Puglia 8
Helsinki 8
Leawood 8
Pune 8
Wuhan 8
Ningbo 7
Santa Marinella 7
Shanghai 7
Wuxi 7
Cosenza 6
San Mateo 6
Tehran 6
West Jordan 6
Zhengzhou 6
Augusta 5
Brno 5
Cerro Maggiore 5
Jinan 5
Moscow 5
Prescot 5
Amsterdam 4
Ardabil 4
Guwahati 4
Hanoi 4
Hefei 4
Kilburn 4
Salice Salentino 4
Triggiano 4
Weihai 4
Yiwu 4
Almere Stad 3
Azrou 3
Bologna 3
Hounslow 3
Irpin 3
Jinhua 3
Kolkata 3
Kunming 3
New Bedfont 3
New Delhi 3
Pavia 3
Qingdao 3
Quanzhou 3
Simi Valley 3
Toronto 3
Turi 3
Visakhapatnam 3
Auburn Hills 2
Carmignano 2
Delhi 2
Edinburgh 2
Frankfurt am Main 2
Grafing 2
Ismailia 2
Totale 4.706
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 220
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 135
A rational approach to elucidate human monoamine oxidase molecular selectivity 133
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 129
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 128
Mind the Gap ! A Journey towards Computational Toxicology 124
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 119
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 117
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 117
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 112
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 111
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 111
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 110
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 110
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 109
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 103
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 102
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 97
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 95
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 94
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 93
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 92
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 89
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 88
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 86
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 86
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 86
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 83
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 82
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 82
null 81
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 79
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 79
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 75
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 75
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 73
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 71
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 70
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 68
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 68
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 67
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 64
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 64
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 64
null 63
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 63
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 62
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 61
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 60
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 59
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 59
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 57
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 57
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 55
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 54
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 53
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 53
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 48
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 48
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 48
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 47
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 47
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 44
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 42
Solid phase synthesis of potential PKs inhibitors 41
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 40
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 40
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 39
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 38
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 38
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 31
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 31
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 30
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 29
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 26
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 24
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 22
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 22
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 22
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 20
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 19
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 18
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 13
null 11
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 10
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 7
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 6
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 5
null 5
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 5
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 4
A Critical Appraisal of the Protecting Activity of Polyphenolic Antioxidants Against Iatrogenic Effects of Anticancer Chemotherapeutics§ 2
Totale 6.002
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Categoria #
all - tutte 25.262
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 25.262
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.241 0 0 30 113 157 132 160 159 188 125 126 51
2020/2021920 107 104 35 47 97 47 50 71 69 127 89 77
2021/2022775 37 115 29 12 35 33 42 28 57 111 96 180
2022/20231.239 171 156 91 103 164 133 12 140 182 26 31 30
2023/2024603 41 63 38 90 38 111 19 23 27 23 16 114
2024/2025114 61 53 0 0 0 0 0 0 0 0 0 0
Totale 6.002