IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 7.870
AS - Asia 2.545
EU - Europa 2.462
SA - Sud America 577
Continente sconosciuto - Info sul continente non disponibili 396
AF - Africa 92
OC - Oceania 3
AN - Antartide 1
Totale 13.946
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Nazione #
US - Stati Uniti d'America 7.649
SG - Singapore 918
IT - Italia 749
CN - Cina 665
BR - Brasile 448
SE - Svezia 367
RU - Federazione Russa 292
HK - Hong Kong 289
DE - Germania 240
VN - Vietnam 194
LT - Lituania 160
FR - Francia 155
GB - Regno Unito 145
IN - India 121
CA - Canada 104
FI - Finlandia 98
UA - Ucraina 63
BD - Bangladesh 60
ID - Indonesia 54
AR - Argentina 43
JP - Giappone 35
BE - Belgio 34
MX - Messico 32
PL - Polonia 32
IQ - Iraq 30
NL - Olanda 28
TR - Turchia 28
CO - Colombia 23
IE - Irlanda 23
ZA - Sudafrica 22
EC - Ecuador 21
ES - Italia 21
CI - Costa d'Avorio 19
IR - Iran 19
PH - Filippine 19
CR - Costa Rica 15
VE - Venezuela 15
AT - Austria 13
NI - Nicaragua 13
MA - Marocco 12
PK - Pakistan 12
SA - Arabia Saudita 12
CH - Svizzera 11
CZ - Repubblica Ceca 11
IL - Israele 11
HN - Honduras 10
KR - Corea 10
MY - Malesia 10
AE - Emirati Arabi Uniti 9
TN - Tunisia 9
EG - Egitto 8
GP - Guadalupe 7
GT - Guatemala 7
BO - Bolivia 6
CL - Cile 6
JM - Giamaica 6
NP - Nepal 6
PE - Perù 6
PY - Paraguay 6
TT - Trinidad e Tobago 6
UZ - Uzbekistan 6
AZ - Azerbaigian 5
CW - ???statistics.table.value.countryCode.CW??? 5
DO - Repubblica Dominicana 5
SV - El Salvador 5
JO - Giordania 4
NG - Nigeria 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
TW - Taiwan 4
AU - Australia 3
ET - Etiopia 3
KE - Kenya 3
KG - Kirghizistan 3
KZ - Kazakistan 3
PA - Panama 3
PR - Porto Rico 3
RS - Serbia 3
SY - Repubblica araba siriana 3
AO - Angola 2
BH - Bahrain 2
DK - Danimarca 2
EE - Estonia 2
EU - Europa 2
LB - Libano 2
RO - Romania 2
SC - Seychelles 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AD - Andorra 1
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AM - Armenia 1
AQ - Antartide 1
BB - Barbados 1
BW - Botswana 1
BY - Bielorussia 1
CV - Capo Verde 1
DZ - Algeria 1
Totale 13.544
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Città #
Dallas 1.016
Ashburn 779
Fairfield 645
Singapore 496
San Jose 434
Chandler 432
Woodbridge 351
Nyköping 285
Hong Kong 283
Houston 266
Seattle 258
Milan 236
Cambridge 235
Ann Arbor 219
Beijing 214
Wilmington 192
Council Bluffs 170
Vilnius 149
Jacksonville 130
Bari 125
New York 107
Los Angeles 100
Boardman 91
Roxbury 80
Lawrence 74
Lauterbourg 73
Nanjing 69
Santa Clara 67
Washington 53
Brooklyn 52
Munich 51
Helsinki 49
Des Moines 48
Rome 46
São Paulo 45
North Bergen 44
Ho Chi Minh City 43
Dearborn 42
Jakarta 41
San Diego 39
Dong Ket 37
Brussels 34
Hanoi 34
Buffalo 33
Falkenstein 33
Princeton 33
Figino 32
London 31
Tokyo 28
Inglewood 27
Frankfurt am Main 26
Montreal 26
Columbus 25
Atlanta 24
Chicago 24
Orem 24
Kansas City 23
Phoenix 23
Warsaw 23
Moscow 22
Nanchang 22
Dublin 21
Hebei 21
Marseille 21
Paris 20
Turin 20
Abidjan 19
The Dalles 19
Baghdad 16
Nuremberg 16
Toronto 16
Denver 15
Johannesburg 15
San Francisco 15
Guangzhou 14
Naples 14
New Delhi 14
Amsterdam 13
Redwood City 13
Rio de Janeiro 13
Shenyang 13
Boston 12
Boydton 12
Managua 12
Shanghai 12
Jiaxing 11
San José 11
Wuhan 11
Bologna 10
Brasília 10
Chennai 10
Genoa 10
Mumbai 10
Changsha 9
Chapel Hill 9
Mexico City 9
Norwalk 9
Poplar 9
Tianjin 9
Gravina In Puglia 8
Totale 9.234
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.141
A rational approach to elucidate human monoamine oxidase molecular selectivity 363
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 228
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 227
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 223
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 219
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 217
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 214
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 212
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 211
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 208
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 205
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 204
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 202
Mind the Gap ! A Journey towards Computational Toxicology 201
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 192
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 192
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 190
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 186
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 184
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 183
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 183
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 179
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 179
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 177
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 171
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 170
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 168
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 156
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 156
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 155
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 154
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 154
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 152
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 151
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 151
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 151
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 149
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 147
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 137
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 133
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 132
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 130
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 129
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 129
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 129
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 126
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 125
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 125
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 124
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 124
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 124
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 122
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 121
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 120
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 119
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 118
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 114
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 111
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 110
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 108
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 107
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 106
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 106
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 105
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 102
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 102
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 101
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 100
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 98
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 97
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 96
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 94
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 94
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 91
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 91
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 89
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 86
Solid phase synthesis of potential PKs inhibitors 83
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 79
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 78
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 78
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 77
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 77
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 76
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 76
Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds 74
null 63
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 62
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors 61
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 60
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 59
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 57
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 54
A second life for MAO inhibitors: from CNS diseases to cancer 51
Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities 48
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes 38
Nanostructured Lipid Carriers Enhance Brain Delivery and Antioxidant Efficacy of a Small-Molecule MAO B Inhibitor for Neurodegenerative Disease Therapy 8
PROTAC-Based Strategies in Neurodegenerative Diseases: Challenges and Perspectives 7
Totale 13.946
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Categoria #
all - tutte 51.270
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.270
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022582 0 0 0 0 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/20251.804 59 53 132 90 60 128 227 160 94 68 289 444
2025/20265.027 536 351 979 415 508 221 463 146 436 344 161 467
2026/20271.283 92 162 344 600 85 0 0 0 0 0 0 0
Totale 13.946