IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 4.181
EU - Europa 1.092
AS - Asia 666
AF - Africa 8
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 2
Totale 5.955
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Nazione #
US - Stati Uniti d'America 4.175
CN - Cina 394
SE - Svezia 356
IT - Italia 249
SG - Singapore 158
DE - Germania 129
GB - Regno Unito 81
FI - Finlandia 67
UA - Ucraina 51
RU - Federazione Russa 43
FR - Francia 42
VN - Vietnam 41
IN - India 38
BE - Belgio 29
IR - Iran 17
IE - Irlanda 16
NL - Olanda 10
CA - Canada 6
CZ - Repubblica Ceca 6
TR - Turchia 5
CH - Svizzera 4
JP - Giappone 4
MA - Marocco 4
HK - Hong Kong 3
KR - Corea 3
LT - Lituania 3
EG - Egitto 2
ES - Italia 2
EU - Europa 2
NG - Nigeria 2
AD - Andorra 1
AR - Argentina 1
BR - Brasile 1
CL - Cile 1
CO - Colombia 1
DK - Danimarca 1
EC - Ecuador 1
IL - Israele 1
IS - Islanda 1
NP - Nepal 1
PE - Perù 1
PL - Polonia 1
TW - Taiwan 1
Totale 5.955
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Città #
Fairfield 645
Chandler 431
Ashburn 356
Woodbridge 351
Nyköping 285
Houston 258
Seattle 251
Cambridge 234
Ann Arbor 219
Wilmington 190
Singapore 136
Jacksonville 129
Bari 118
Roxbury 80
Lawrence 74
Beijing 71
Nanjing 69
Boardman 63
Des Moines 47
New York 43
Dearborn 42
Dong Ket 37
San Diego 37
Brooklyn 36
Princeton 31
Brussels 29
Inglewood 27
Helsinki 24
Milan 22
Nanchang 22
Hebei 21
Los Angeles 20
Marseille 19
Kansas City 18
London 17
Munich 17
Dublin 16
Guangzhou 13
Paris 13
Redwood City 13
Santa Clara 12
Shenyang 12
Washington 12
Boydton 10
Jiaxing 10
Shanghai 10
Changsha 9
Norwalk 9
Tianjin 9
Wuhan 9
Gravina In Puglia 8
Leawood 8
Pune 8
Zhengzhou 8
Ningbo 7
Santa Marinella 7
Cosenza 6
Jinan 6
San Mateo 6
Tehran 6
West Jordan 6
Wuxi 6
Augusta 5
Brno 5
Cerro Maggiore 5
Kolkata 5
Moscow 5
Amsterdam 4
Ardabil 4
Guwahati 4
Hanoi 4
Hefei 4
Kilburn 4
Kunming 4
Prescot 4
Salice Salentino 4
Triggiano 4
Weihai 4
Yiwu 4
Almere Stad 3
Azrou 3
Bologna 3
Hounslow 3
Jinhua 3
New Bedfont 3
New Delhi 3
Qingdao 3
Quanzhou 3
Romola 3
Simi Valley 3
Toronto 3
Visakhapatnam 3
Auburn Hills 2
Berlin 2
Carmignano 2
Daejeon 2
Delhi 2
Edinburgh 2
Frankfurt am Main 2
Grafing 2
Totale 4.836
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 227
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 141
A rational approach to elucidate human monoamine oxidase molecular selectivity 138
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 133
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 132
Mind the Gap ! A Journey towards Computational Toxicology 127
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 124
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 124
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 121
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 117
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 117
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 117
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 113
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 113
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 112
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 109
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 104
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 100
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 99
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 98
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 95
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 94
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 92
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 92
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 91
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 88
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 87
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 87
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 85
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 84
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 84
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 83
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 83
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 83
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 81
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 77
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 76
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 73
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 73
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 73
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 72
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 71
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 69
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 68
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 68
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 67
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 64
null 63
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 63
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 63
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 62
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 62
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 61
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 60
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 60
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 59
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 56
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 55
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 55
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 55
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 53
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 52
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 51
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 51
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 48
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 44
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 43
Solid phase synthesis of potential PKs inhibitors 42
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 41
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 41
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 40
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 36
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 35
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 32
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 32
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 29
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 28
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 28
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 24
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 24
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 24
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 21
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 21
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 15
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 13
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 10
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 7
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 6
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 5
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 2
Totale 6.298
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Categoria #
all - tutte 27.470
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.470
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020941 0 0 0 0 0 132 160 159 188 125 126 51
2020/2021920 107 104 35 47 97 47 50 71 69 127 89 77
2021/2022775 37 115 29 12 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/2025466 59 53 130 87 56 81 0 0 0 0 0 0
Totale 6.298