IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 6.050
AS - Asia 2.082
EU - Europa 1.617
SA - Sud America 430
AF - Africa 63
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
AN - Antartide 1
Totale 10.248
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Nazione #
US - Stati Uniti d'America 5.985
SG - Singapore 797
CN - Cina 598
BR - Brasile 374
SE - Svezia 366
RU - Federazione Russa 284
IT - Italia 274
HK - Hong Kong 272
DE - Germania 218
VN - Vietnam 156
GB - Regno Unito 125
IN - India 78
FI - Finlandia 75
FR - Francia 62
UA - Ucraina 57
ID - Indonesia 41
CA - Canada 34
BE - Belgio 32
PL - Polonia 25
NL - Olanda 24
BD - Bangladesh 23
AR - Argentina 22
JP - Giappone 21
CI - Costa d'Avorio 19
IR - Iran 19
IE - Irlanda 18
MX - Messico 18
ZA - Sudafrica 17
IQ - Iraq 16
TR - Turchia 15
AT - Austria 13
ES - Italia 12
CZ - Repubblica Ceca 9
EC - Ecuador 9
KR - Corea 9
LT - Lituania 9
CO - Colombia 8
TN - Tunisia 7
VE - Venezuela 7
AE - Emirati Arabi Uniti 6
CH - Svizzera 5
MA - Marocco 5
PH - Filippine 5
PK - Pakistan 5
NG - Nigeria 4
PE - Perù 4
CR - Costa Rica 3
EG - Egitto 3
IL - Israele 3
NP - Nepal 3
SA - Arabia Saudita 3
AO - Angola 2
AU - Australia 2
CL - Cile 2
DO - Repubblica Dominicana 2
EU - Europa 2
JM - Giamaica 2
JO - Giordania 2
OM - Oman 2
PY - Paraguay 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
UY - Uruguay 2
AD - Andorra 1
AQ - Antartide 1
BB - Barbados 1
BH - Bahrain 1
BY - Bielorussia 1
CV - Capo Verde 1
DK - Danimarca 1
DZ - Algeria 1
ET - Etiopia 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
HN - Honduras 1
IS - Islanda 1
KG - Kirghizistan 1
KZ - Kazakistan 1
MG - Madagascar 1
MW - Malawi 1
MY - Malesia 1
NI - Nicaragua 1
PA - Panama 1
PT - Portogallo 1
RS - Serbia 1
TT - Trinidad e Tobago 1
UG - Uganda 1
UZ - Uzbekistan 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 10.248
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Città #
Dallas 1.006
Fairfield 645
Ashburn 568
Chandler 431
Singapore 399
Woodbridge 351
Nyköping 285
Hong Kong 266
Houston 264
Seattle 257
Cambridge 234
Ann Arbor 219
Beijing 200
Wilmington 191
Jacksonville 129
Bari 123
Roxbury 80
New York 79
Los Angeles 75
Lawrence 74
Nanjing 69
Boardman 63
Munich 51
Brooklyn 49
Des Moines 47
Dearborn 42
Jakarta 39
Ho Chi Minh City 38
Dong Ket 37
San Diego 37
North Bergen 35
Council Bluffs 33
São Paulo 33
Brussels 32
Princeton 31
Buffalo 29
London 29
Santa Clara 28
Hanoi 27
Inglewood 27
Falkenstein 26
Helsinki 26
Milan 22
Moscow 22
Nanchang 22
Hebei 21
Abidjan 19
Kansas City 19
Marseille 19
Chicago 18
Dublin 17
Orem 17
Tokyo 17
Warsaw 17
Nuremberg 16
Frankfurt am Main 14
Guangzhou 14
Paris 14
The Dalles 14
Atlanta 13
Montreal 13
Redwood City 13
San Francisco 13
Shenyang 13
Columbus 12
Johannesburg 12
Washington 12
Amsterdam 11
Denver 11
Rio de Janeiro 11
San Jose 11
Shanghai 11
Boydton 10
Chennai 10
Jiaxing 10
Toronto 10
Boston 9
Changsha 9
Mumbai 9
New Delhi 9
Norwalk 9
Tianjin 9
Wuhan 9
Baghdad 8
Brasília 8
Gravina In Puglia 8
Leawood 8
Poplar 8
Pune 8
Stockholm 8
Tehran 8
Zhengzhou 8
Campo Grande 7
Haiphong 7
Ningbo 7
Santa Marinella 7
Belo Horizonte 6
Cosenza 6
Da Nang 6
Jinan 6
Totale 7.389
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.062
A rational approach to elucidate human monoamine oxidase molecular selectivity 187
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 185
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 181
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 181
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 178
Mind the Gap ! A Journey towards Computational Toxicology 176
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 168
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 166
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 166
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 164
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 163
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 156
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 155
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 147
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 146
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 146
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 146
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 145
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 144
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 144
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 144
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 142
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 138
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 136
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 130
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 130
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 129
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 122
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 122
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 121
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 121
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 120
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 116
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 115
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 115
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 111
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 111
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 110
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 110
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 108
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 108
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 107
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 103
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 103
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 101
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 97
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 96
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 96
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 95
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 94
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 94
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 90
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 89
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 86
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 84
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 83
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 82
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 82
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 81
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 81
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 79
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 79
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 77
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 77
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 75
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 74
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 73
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 72
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 71
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 71
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 70
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 67
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 66
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 64
null 63
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 61
Solid phase synthesis of potential PKs inhibitors 59
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 57
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 55
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 55
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 52
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 49
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 48
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 48
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 42
Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds 41
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors 40
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 39
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 38
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 36
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 35
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 25
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 18
Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities 13
A second life for MAO inhibitors: from CNS diseases to cancer 9
Totale 10.625
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Categoria #
all - tutte 41.496
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.496
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021530 0 0 0 0 0 47 50 71 69 127 89 77
2021/2022775 37 115 29 12 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/20251.804 59 53 132 90 60 128 227 160 94 68 289 444
2025/20262.989 536 351 979 416 522 185 0 0 0 0 0 0
Totale 10.625