IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 6.705
AS - Asia 2.473
EU - Europa 1.833
SA - Sud America 550
AF - Africa 89
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 3
AN - Antartide 1
Totale 11.658
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Nazione #
US - Stati Uniti d'America 6.608
SG - Singapore 913
CN - Cina 651
BR - Brasile 434
SE - Svezia 367
IT - Italia 309
RU - Federazione Russa 288
HK - Hong Kong 285
DE - Germania 239
VN - Vietnam 191
FR - Francia 153
GB - Regno Unito 134
IN - India 116
FI - Finlandia 98
UA - Ucraina 63
ID - Indonesia 52
CA - Canada 47
BD - Bangladesh 42
AR - Argentina 40
BE - Belgio 33
JP - Giappone 33
IQ - Iraq 29
MX - Messico 29
PL - Polonia 29
TR - Turchia 28
NL - Olanda 27
ZA - Sudafrica 23
IE - Irlanda 20
CI - Costa d'Avorio 19
IR - Iran 19
CO - Colombia 18
EC - Ecuador 18
PH - Filippine 18
ES - Italia 17
AT - Austria 13
VE - Venezuela 13
MA - Marocco 12
CZ - Repubblica Ceca 10
KR - Corea 10
LT - Lituania 10
MY - Malesia 10
PK - Pakistan 10
SA - Arabia Saudita 10
TN - Tunisia 10
AE - Emirati Arabi Uniti 9
CH - Svizzera 8
EG - Egitto 7
BO - Bolivia 6
CL - Cile 6
NP - Nepal 6
PE - Perù 6
PY - Paraguay 6
UZ - Uzbekistan 6
CR - Costa Rica 5
AZ - Azerbaigian 4
IL - Israele 4
JO - Giordania 4
NG - Nigeria 4
OM - Oman 4
TW - Taiwan 4
AU - Australia 3
DO - Repubblica Dominicana 3
ET - Etiopia 3
KG - Kirghizistan 3
KZ - Kazakistan 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
AO - Angola 2
BH - Bahrain 2
DK - Danimarca 2
EU - Europa 2
JM - Giamaica 2
KE - Kenya 2
LB - Libano 2
NI - Nicaragua 2
RS - Serbia 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AD - Andorra 1
AQ - Antartide 1
BB - Barbados 1
BY - Bielorussia 1
CV - Capo Verde 1
DZ - Algeria 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
HN - Honduras 1
HR - Croazia 1
IS - Islanda 1
MG - Madagascar 1
MT - Malta 1
MW - Malawi 1
PT - Portogallo 1
RO - Romania 1
RW - Ruanda 1
SO - Somalia 1
SR - Suriname 1
Totale 11.656
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Città #
Dallas 1.007
Fairfield 645
Ashburn 630
Singapore 494
Chandler 431
Woodbridge 351
San Jose 300
Nyköping 285
Hong Kong 279
Houston 265
Seattle 258
Cambridge 234
Ann Arbor 219
Beijing 206
Wilmington 191
Jacksonville 129
Bari 123
New York 84
Council Bluffs 83
Roxbury 80
Los Angeles 77
Lawrence 74
Lauterbourg 73
Nanjing 69
Boardman 63
Munich 51
Brooklyn 50
Helsinki 49
Des Moines 48
Ho Chi Minh City 43
Dearborn 42
São Paulo 42
Jakarta 41
San Diego 38
Dong Ket 37
North Bergen 37
Santa Clara 35
Hanoi 34
Brussels 33
Falkenstein 33
Princeton 32
London 30
Buffalo 29
Inglewood 27
Frankfurt am Main 26
Tokyo 26
Milan 25
Orem 23
Moscow 22
Nanchang 22
Hebei 21
Marseille 21
Warsaw 21
Chicago 20
Paris 20
Abidjan 19
Dublin 19
Kansas City 19
Atlanta 16
Baghdad 16
Nuremberg 16
Johannesburg 15
Guangzhou 14
Montreal 14
San Francisco 14
The Dalles 14
Amsterdam 13
Columbus 13
Denver 13
New Delhi 13
Redwood City 13
Rio de Janeiro 13
Shenyang 13
Shanghai 12
Toronto 12
Washington 12
Chennai 11
Jiaxing 11
Wuhan 11
Boydton 10
Mumbai 10
Boston 9
Changsha 9
Norwalk 9
Phoenix 9
Poplar 9
Tianjin 9
Brasília 8
Gravina In Puglia 8
Haiphong 8
Leawood 8
Pune 8
Stockholm 8
Tehran 8
Zhengzhou 8
Campo Grande 7
Kolkata 7
Medellín 7
Ningbo 7
Porto Alegre 7
Totale 8.137
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.089
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 210
A rational approach to elucidate human monoamine oxidase molecular selectivity 202
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 202
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 201
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 198
Mind the Gap ! A Journey towards Computational Toxicology 190
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 188
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 185
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 183
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 182
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 180
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 180
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 177
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 168
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 165
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 165
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 163
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 162
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 161
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 160
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 157
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 157
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 156
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 154
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 148
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 146
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 139
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 138
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 137
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 137
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 136
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 131
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 131
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 131
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 128
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 126
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 121
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 120
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 119
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 118
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 116
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 116
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 115
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 113
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 109
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 108
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 107
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 106
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 104
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 103
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 102
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 100
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 100
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 96
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 96
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 95
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 94
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 93
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 92
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 92
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 90
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 89
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 86
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 86
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 86
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 86
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 84
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 82
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 80
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 79
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 79
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 77
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 75
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 74
Solid phase synthesis of potential PKs inhibitors 70
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 66
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 63
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 63
null 63
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 63
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 63
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 60
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 59
Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds 59
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 50
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 50
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors 49
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 48
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 42
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 42
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 28
A second life for MAO inhibitors: from CNS diseases to cancer 23
Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities 21
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 6
Totale 12.036
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Categoria #
all - tutte 43.959
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.959
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021293 0 0 0 0 0 0 0 0 0 127 89 77
2021/2022775 37 115 29 12 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/20251.804 59 53 132 90 60 128 227 160 94 68 289 444
2025/20264.400 536 351 979 416 522 225 464 148 442 317 0 0
Totale 12.036