IRIS
PISANI, LEONARDO
 Distribuzione geografica
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Continente #
NA - Nord America 7.237
AS - Asia 2.529
EU - Europa 2.239
SA - Sud America 570
Continente sconosciuto - Info sul continente non disponibili 387
AF - Africa 90
OC - Oceania 3
AN - Antartide 1
Totale 13.056
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Nazione #
US - Stati Uniti d'America 7.113
SG - Singapore 917
IT - Italia 701
CN - Cina 663
BR - Brasile 443
SE - Svezia 367
HK - Hong Kong 289
RU - Federazione Russa 288
DE - Germania 239
VN - Vietnam 194
FR - Francia 153
GB - Regno Unito 134
IN - India 119
FI - Finlandia 98
UA - Ucraina 63
BD - Bangladesh 60
CA - Canada 60
ID - Indonesia 53
AR - Argentina 42
BE - Belgio 34
JP - Giappone 33
MX - Messico 32
IQ - Iraq 29
PL - Polonia 29
NL - Olanda 28
TR - Turchia 28
CO - Colombia 23
ZA - Sudafrica 22
EC - Ecuador 21
IE - Irlanda 21
ES - Italia 20
CI - Costa d'Avorio 19
IR - Iran 19
PH - Filippine 19
VE - Venezuela 14
AT - Austria 13
MA - Marocco 12
PK - Pakistan 12
SA - Arabia Saudita 12
CH - Svizzera 11
CZ - Repubblica Ceca 11
KR - Corea 10
LT - Lituania 10
MY - Malesia 10
AE - Emirati Arabi Uniti 9
TN - Tunisia 9
CR - Costa Rica 8
EG - Egitto 8
BO - Bolivia 6
CL - Cile 6
NP - Nepal 6
PE - Perù 6
PY - Paraguay 6
UZ - Uzbekistan 6
AZ - Azerbaigian 5
JM - Giamaica 5
DO - Repubblica Dominicana 4
IL - Israele 4
JO - Giordania 4
NG - Nigeria 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
TW - Taiwan 4
AU - Australia 3
ET - Etiopia 3
KE - Kenya 3
KG - Kirghizistan 3
KZ - Kazakistan 3
NI - Nicaragua 3
PA - Panama 3
RS - Serbia 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
AO - Angola 2
BH - Bahrain 2
DK - Danimarca 2
EU - Europa 2
HN - Honduras 2
LB - Libano 2
RO - Romania 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AD - Andorra 1
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AM - Armenia 1
AQ - Antartide 1
BB - Barbados 1
BW - Botswana 1
BY - Bielorussia 1
CV - Capo Verde 1
DZ - Algeria 1
EE - Estonia 1
GE - Georgia 1
GI - Gibilterra 1
GT - Guatemala 1
HR - Croazia 1
IS - Islanda 1
MG - Madagascar 1
Totale 12.665
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Città #
Dallas 1.013
Ashburn 679
Fairfield 645
Singapore 496
Chandler 432
San Jose 366
Woodbridge 351
Nyköping 285
Hong Kong 283
Houston 266
Seattle 258
Cambridge 235
Milan 233
Ann Arbor 219
Beijing 214
Wilmington 192
Council Bluffs 168
Jacksonville 130
Bari 124
New York 99
Boardman 88
Los Angeles 86
Roxbury 80
Lawrence 74
Lauterbourg 73
Nanjing 69
Santa Clara 61
Brooklyn 51
Munich 51
Helsinki 49
Des Moines 48
Rome 45
Ho Chi Minh City 43
São Paulo 43
Dearborn 42
Jakarta 41
San Diego 39
Dong Ket 37
North Bergen 37
Brussels 34
Hanoi 34
Buffalo 33
Falkenstein 33
Figino 32
Princeton 32
London 30
Inglewood 27
Frankfurt am Main 26
Tokyo 26
Columbus 25
Orem 24
Kansas City 23
Chicago 22
Moscow 22
Nanchang 22
Hebei 21
Marseille 21
Warsaw 21
Paris 20
Abidjan 19
Atlanta 19
Dublin 19
The Dalles 19
Montreal 18
Phoenix 18
Baghdad 16
Nuremberg 16
Turin 16
Johannesburg 15
Denver 14
Guangzhou 14
New Delhi 14
San Francisco 14
Amsterdam 13
Redwood City 13
Rio de Janeiro 13
Shenyang 13
Toronto 13
Washington 13
Boydton 12
Shanghai 12
Jiaxing 11
Wuhan 11
Boston 10
Chennai 10
Genoa 10
Mumbai 10
Bologna 9
Changsha 9
Mexico City 9
Naples 9
Norwalk 9
Poplar 9
Tianjin 9
Brasília 8
Gravina In Puglia 8
Haiphong 8
Leawood 8
Medellín 8
Pune 8
Totale 8.779
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.120
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 219
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 219
A rational approach to elucidate human monoamine oxidase molecular selectivity 218
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 214
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 212
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 204
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 201
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 200
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 197
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 196
Mind the Gap ! A Journey towards Computational Toxicology 196
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 194
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 193
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 184
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 182
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 180
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 178
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 173
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 173
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 173
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 173
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 168
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 164
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 164
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 162
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 149
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 149
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 147
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 145
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 145
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 144
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 143
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 143
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 139
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 134
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 133
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 130
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 125
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 124
Synthesis of 5-Aroyldihydropyrimidinones via Liebeskind–Srogl Thiol Ester– Boronic Acid Cross-Couplings 124
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 124
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 122
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 118
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 118
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 117
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 117
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 116
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 116
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 116
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 114
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization 110
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 110
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 108
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 107
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 107
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 105
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS 103
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 102
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 101
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 99
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 97
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 96
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 96
Novel 6-hydroxybenzothiazol-2-carboxamides as potent and selective monoamine oxidase B inhibitors endowed with neuroprotective activity 96
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 95
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 92
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 91
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors 90
Ring closing metathesis mediated synthesis of d-, g- and e-N-HydroxylactaMS as potential coordinating molecular fragments of biologically relevant bivalent metals XX 89
Solid-phase and Microwave Assisted Synthesis of Focused libraries of Imatinib analogues 87
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation 87
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 83
Solid phase synthesis of potential PKs inhibitors 79
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 77
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 76
Rational Redesign of Monoamine Oxidase A into a Dehydrogenase to Probe ROS in Cardiac Aging 72
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease 70
Synthesis of heterocyclic compound libraries by automated sequential and parallel microwave synthesis. 70
Monoamine Oxidase Inhibition for the Treatment of Neurodegenerative Diseases: Rationale, Assay Methodologies, and Reference Compounds 69
In silico design and microwave-assisted solid phase synthesis of focused libraries of enzyme inhibitors with potential in cancer and neurological therapies 69
Playing Around the Coumarin Core in the Discovery of Multimodal Compounds Directed at Alzheimer’s-Related Targets: A Recent Literature Overview 68
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 67
null 63
Dihydroquinazolinebenzylamides as Acetylcholinesterase and Butyrylcholinesterase inhibitors. 57
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors 54
Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures 54
Informed Use of 3D-QSAR for the Rational Design of Coumarin Derivatives as Potent and Selective MAO B Inhibitors 53
Synthesis and pharmacological evaluation of novel N-aryl-cinnamoyl-hydrazone hybrids designed as neuroprotective agents for the treatment of Parkinson’s disease 52
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 50
A second life for MAO inhibitors: from CNS diseases to cancer 43
Microwave-Assisted Extraction of Pleurotus Mushrooms Cultivated on ‘Nero di Troia’ Grape Pomace and Evaluation of the Antioxidant and Antiacetylcholinesterase Activities 27
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes 16
Totale 13.056
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Categoria #
all - tutte 48.727
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 48.727
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022623 0 0 29 12 35 33 42 28 57 111 96 180
2022/20231.215 169 154 89 102 157 132 12 138 179 23 30 30
2023/2024571 41 59 37 86 35 107 15 23 27 21 15 105
2024/20251.804 59 53 132 90 60 128 227 160 94 68 289 444
2025/20265.027 536 351 979 415 508 221 463 146 436 344 161 467
2026/2027393 92 162 139 0 0 0 0 0 0 0 0 0
Totale 13.056