PISANI, LEONARDO

PISANI, LEONARDO  

DIPARTIMENTO DI FARMACIA-SCIENZE DEL FARMACO  

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Titolo Data di pubblicazione Autore(i) File
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1-gen-2019 Rullo, Mariagrazia; Niso, Mauro; Pisani, Leonardo; Carrieri, Antonio; Colabufo, Nicola Antonio; Cellamare, Saverio; Altomare, Cosimo Damiano
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 1-gen-2019 Titov, A. A.; Niso, M.; Candia, M.; Kobzev, M. S.; Varlamov, A. V.; Borisova, T. N.; Voskressensky, L. G.; Colabufo, N. A.; Cellamare, S.; Pisani, L.; Altomare, C. D.
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 1-gen-2013 Pisani, Leonardo; Catto, Marco; Stefanachi, Angela; Leonetti, F; Campagna, Francesco; Nicolotti, O; SOTO OTERO, R; Carotti, A.
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 1-gen-2013 Pisani, L.; Catto, M.; Stefanachi, A.; Leonetti, F.; Campagna, F.; Nicolotti, O.; Soto-Otero, R.; Carotti, A.
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview) 1-gen-2018 Rullo, Mariagrazia; Pisani, Leonardo
5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques 1-gen-2007 Pisani, Leonardo; Prokopcová, Hana; Kremsner, Jennifer M.; Oliver Kappe, C.
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 1-gen-2011 Barletta, M.; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Soto Otero, R.; Carotti, Angelo
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 1-gen-2016 Dominguez, J. L.; Fernandez-Nieto, F.; Brea, J. M.; Catto, M.; Paleo, M. R.; Porto, S.; Sardina, F. J.; Castro, M.; Pisani, L.; Carotti, A.; Soto-Otero, R.; Mendez-Alvarez, E.; Villaverde, M. C.; Sussman, F.
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 1-gen-2010 Nicolotti, Orazio; Giangreco, I; Pisani, Leonardo; Catto, Marco; Leonetti, Francesco; Stefanachi, Angela; Cellamare, Saverio; Carotti, A.
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 1-gen-2019 Altomare, C. D.; de Candia, M.; Purgatorio, R.; Pisani, L.; Catto, M.; Cellamare, S.; Titov, A. A.; Voskressensky, L. G.
Application of Liebeskind-Srogl Thioester-Boronic Acid Couplings for the Scaffold Decoration of Dihydropyrimidines 1-gen-2006 Pisani, L.; Prokopcová, H.; Kappe, C. O.
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 1-gen-2018 Mangiatordi, G. F.; Trisciuzzi, D.; Iacobazzi, R.; Denora, N.; Pisani, L.; Catto, M.; Leonetti, F.; Alberga, D.; Nicolotti, O.
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 1-gen-2021 Titov, Alexander A; Kobzev, Maxim S; Catto, Marco; Candia, Modesto de; Gambacorta, Nicola; Denora, Nunzio; Pisani, Leonardo; Nicolotti, Orazio; Borisova, Tatiana N; Varlamov, Alexey V; Voskressensky, Leonid G; Altomare, Cosimo D
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 1-gen-2011 Leonetti, Francesco; Stefanachi, Angela; Nicolotti, Orazio; Catto, Marco; Pisani, Leonardo; Cellamare, Saverio; Carotti, Angelo
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 1-gen-2019 Rullo, Mariagrazia; Catto, Marco; Carrieri, Antonio; de Candia, Modesto; Altomare, Cosimo damiano; Pisani, Leonardo
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 1-gen-2020 Catto, Marco; Pisani, Leonardo; de la Mora, Eugenio; Belviso, Benny Danilo; Mangiatordi, Giuseppe Felice; Pinto, Andrea; Palma, Annalisa De; Denora, Nunzio; Caliandro, Rocco; Colletier, Jacques-Philippe; Silman, Israel; Nicolotti, Orazio; Altomare, Cosimo Damiano
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 1-gen-2011 Stefanachi, Angela; Favia, Ad; Nicolotti, Orazio; Leonetti, Francesco; Pisani, Leonardo; Catto, Marco; Zimmer, C; Hartmann, Rw; Cellamare, Saverio; Carotti, Angelo
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 1-gen-2018 Stefanachi, Angela; Leonetti, Francesco; Pisani, Leonardo; Catto, Marco; Carotti, Angelo
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 1-gen-2019 Oukoloff, Killian; Coquelle, Nicolas; Bartolini, Manuela; Naldi, Marina; Le Guevel, Rémy; Bach, Stéphane; Josselin, Béatrice; Ruchaud, Sandrine; Catto, Marco; Pisani, Leonardo; Denora, Nunzio; Iacobazzi, Rosa Maria; Silman, Israel; Sussman, Joel L.; Buron, Frédéric; Colletier, Jacques-Philippe; Jean, Ludovic; Routier, Sylvain; Renard, Pierre-Yves
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 1-gen-2012 Nicolotti, Orazio; Catto, Marco; Giangreco, Ilenia; Barletta, Maria; Leonetti, Francesco; Stefanachi, Angela; Pisani, Leonardo; Cellamare, Saverio; Tortorella, Paolo; Loiodice, Fulvio; Carotti, Angelo