PISANI, LEONARDO
 Distribuzione geografica
Continente #
NA - Nord America 559
EU - Europa 429
AS - Asia 196
AF - Africa 18
SA - Sud America 6
OC - Oceania 5
Totale 1.213
Nazione #
US - Stati Uniti d'America 541
IT - Italia 229
CN - Cina 70
FR - Francia 57
IN - India 54
DE - Germania 35
ES - Italia 22
CA - Canada 12
JP - Giappone 12
IR - Iran 11
BE - Belgio 10
GB - Regno Unito 10
VN - Vietnam 9
EG - Egitto 8
FI - Finlandia 8
PL - Polonia 8
TR - Turchia 8
CZ - Repubblica Ceca 7
HK - Hong Kong 7
NL - Olanda 7
RU - Federazione Russa 7
NO - Norvegia 6
UA - Ucraina 6
AU - Australia 5
MX - Messico 5
TH - Thailandia 5
CH - Svizzera 4
AE - Emirati Arabi Uniti 3
BD - Bangladesh 3
DZ - Algeria 3
IE - Irlanda 3
PK - Pakistan 3
RS - Serbia 3
ZA - Sudafrica 3
AR - Argentina 2
CL - Cile 2
CO - Colombia 2
IQ - Iraq 2
MA - Marocco 2
MY - Malesia 2
SA - Arabia Saudita 2
SE - Svezia 2
AM - Armenia 1
BG - Bulgaria 1
CM - Camerun 1
GR - Grecia 1
GT - Guatemala 1
HR - Croazia 1
KR - Corea 1
LT - Lituania 1
NG - Nigeria 1
SG - Singapore 1
SI - Slovenia 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 1.213
Città #
Bari 87
Ashburn 82
Boardman 30
Columbus 29
Seattle 26
Chicago 25
Fairfield 23
Los Angeles 19
Houston 15
Buffalo 11
Hangzhou 10
New York 10
Dallas 9
Dong Ket 9
Arezzo 8
Cambridge 8
Council Bluffs 8
Paris 8
Santa Marinella 8
Shanghai 8
Acquaviva delle Fonti 7
Anderlecht 7
Ann Arbor 7
Helsinki 7
Henderson 7
Wilmington 7
Woodbridge 7
Madison 6
Rome 6
Stavanger 6
Taranto 6
Cornellà de Llobregat 5
Figueres 5
Guangzhou 5
Hong Kong 5
Kottayam 5
Lecce 5
Milan 5
Philadelphia 5
San Diego 5
Seville 5
Beijing 4
Catania 4
Cedar Knolls 4
Esslingen am Neckar 4
Guiyang 4
Guwahati 4
Istanbul 4
Pune 4
Salice Salentino 4
Sydney 4
Tappahannock 4
Zanjan 4
Zapopan 4
Bangkok 3
Bologna 3
Brussels 3
Caluire-et-Cuire 3
Cosenza 3
Delhi 3
Dombivali 3
Dublin 3
Edmonton 3
Falkenstein 3
Grenoble 3
Kochi 3
Kolkata 3
Kumamoto 3
Las Vegas 3
Molfetta 3
Mumbai 3
Nanjing 3
Nuremberg 3
Pasadena 3
Thoothukudi 3
Winnipeg 3
Adana 2
Ahmedabad 2
Atlanta 2
Bani Suwayf 2
Belgrade 2
Brno 2
Cagliari 2
Cairo 2
Camerino 2
Central 2
Chuadanga 2
Coimbatore 2
Erbil 2
Groningen 2
Gunzenhausen 2
Irkutsk 2
Islamabad 2
Jaipur 2
Jalandhar 2
Kirkland 2
Kuala Lumpur 2
Madrid 2
Medellín 2
Milwaukee 2
Totale 722
Nome #
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones, file dd9e0c67-83ef-1e9c-e053-3a05fe0a45ef 142
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease, file dd9e0c65-f80f-1e9c-e053-3a05fe0a45ef 98
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c6c-2499-1e9c-e053-3a05fe0a45ef 94
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity, file dd9e0c67-ae48-1e9c-e053-3a05fe0a45ef 75
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease, file 7fb11c95-4318-4948-bfdb-f470f419ff1e 73
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c6c-24fa-1e9c-e053-3a05fe0a45ef 68
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c6c-8224-1e9c-e053-3a05fe0a45ef 67
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity, file 2f0739a3-e288-42c7-8c5c-ad7778bfba68 58
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors, file dd9e0c6c-2bc6-1e9c-e053-3a05fe0a45ef 56
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors, file dd9e0c6c-2bcb-1e9c-e053-3a05fe0a45ef 56
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties, file dd9e0c67-5731-1e9c-e053-3a05fe0a45ef 47
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase, file dd9e0c6c-87fe-1e9c-e053-3a05fe0a45ef 45
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif, file dd9e0c67-85a9-1e9c-e053-3a05fe0a45ef 39
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation, file dd9e0c6c-4f18-1e9c-e053-3a05fe0a45ef 39
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease, file dd9e0c65-afdf-1e9c-e053-3a05fe0a45ef 30
A rational approach to elucidate human monoamine oxidase molecular selectivity, file dd9e0c6c-55d2-1e9c-e053-3a05fe0a45ef 29
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds, file dd9e0c6c-5422-1e9c-e053-3a05fe0a45ef 25
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase, file 60693fbf-1cb2-4e38-a541-aa0e4f5dae0d 21
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads., file dd9e0c6a-8b0c-1e9c-e053-3a05fe0a45ef 18
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, file dd9e0c6c-3996-1e9c-e053-3a05fe0a45ef 18
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets, file dd9e0c68-b7a7-1e9c-e053-3a05fe0a45ef 12
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs, file dd9e0c6c-5ef0-1e9c-e053-3a05fe0a45ef 12
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties, file dd9e0c67-8131-1e9c-e053-3a05fe0a45ef 11
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase, file dd9e0c62-a87a-1e9c-e053-3a05fe0a45ef 9
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c62-a4f0-1e9c-e053-3a05fe0a45ef 6
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors, file dd9e0c62-84f3-1e9c-e053-3a05fe0a45ef 4
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, file dd9e0c65-8d26-1e9c-e053-3a05fe0a45ef 4
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation, file dd9e0c67-5c4d-1e9c-e053-3a05fe0a45ef 4
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor, file c46f966c-59e8-425b-83cf-685420ff18d5 3
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors, file dd9e0c62-8126-1e9c-e053-3a05fe0a45ef 3
null, file dd9e0c64-5192-1e9c-e053-3a05fe0a45ef 3
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors, file dd9e0c65-8c00-1e9c-e053-3a05fe0a45ef 3
A rational approach to elucidate human monoamine oxidase molecular selectivity, file dd9e0c67-80b3-1e9c-e053-3a05fe0a45ef 3
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase, file dd9e0c67-85bb-1e9c-e053-3a05fe0a45ef 3
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease, file dd9e0c69-1f23-1e9c-e053-3a05fe0a45ef 3
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease, file dd9e0c6b-86ca-1e9c-e053-3a05fe0a45ef 3
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease, file 6cbd6177-b7eb-4853-a0eb-c81bad380b4a 2
null, file dd9e0c62-6913-1e9c-e053-3a05fe0a45ef 2
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile, file dd9e0c62-a8f3-1e9c-e053-3a05fe0a45ef 2
Mind the Gap ! A Journey towards Computational Toxicology, file dd9e0c63-6507-1e9c-e053-3a05fe0a45ef 2
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs, file dd9e0c64-9098-1e9c-e053-3a05fe0a45ef 2
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors, file dd9e0c67-1352-1e9c-e053-3a05fe0a45ef 2
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c67-150f-1e9c-e053-3a05fe0a45ef 2
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c67-3862-1e9c-e053-3a05fe0a45ef 2
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c67-58d1-1e9c-e053-3a05fe0a45ef 2
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease, file dd9e0c6a-950a-1e9c-e053-3a05fe0a45ef 2
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential, file dd9e0c6a-ce75-1e9c-e053-3a05fe0a45ef 2
null, file 607a5de4-3a23-49eb-9cbe-1ea91999987e 1
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease, file b53f6f6b-1a5b-4a49-93d1-19dd3032a4e4 1
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor, file dd9e0c62-84f8-1e9c-e053-3a05fe0a45ef 1
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity, file dd9e0c62-a814-1e9c-e053-3a05fe0a45ef 1
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors, file dd9e0c62-aa40-1e9c-e053-3a05fe0a45ef 1
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease, file dd9e0c66-02ee-1e9c-e053-3a05fe0a45ef 1
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview), file dd9e0c67-0a05-1e9c-e053-3a05fe0a45ef 1
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e4-1e9c-e053-3a05fe0a45ef 1
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e5-1e9c-e053-3a05fe0a45ef 1
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance, file dd9e0c67-813d-1e9c-e053-3a05fe0a45ef 1
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors., file dd9e0c67-cdd5-1e9c-e053-3a05fe0a45ef 1
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS, file dd9e0c68-b817-1e9c-e053-3a05fe0a45ef 1
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors, file dd9e0c68-ddff-1e9c-e053-3a05fe0a45ef 1
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease., file dd9e0c6a-6d8d-1e9c-e053-3a05fe0a45ef 1
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease., file dd9e0c6a-8b0e-1e9c-e053-3a05fe0a45ef 1
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets., file dd9e0c6a-b62a-1e9c-e053-3a05fe0a45ef 1
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE), file dd9e0c6c-06fc-1e9c-e053-3a05fe0a45ef 1
Totale 1.223
Categoria #
all - tutte 5.429
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 5.429


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/202011 0 0 0 0 1 0 1 0 0 4 5 0
2020/2021178 37 39 3 7 10 4 10 13 11 17 9 18
2021/2022127 13 4 1 7 7 1 11 6 5 26 33 13
2022/2023427 43 19 67 30 29 16 16 31 67 28 50 31
2023/2024464 40 25 42 59 41 15 44 49 31 50 49 19
Totale 1.223