| Nome |
# |
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Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones, file dd9e0c67-83ef-1e9c-e053-3a05fe0a45ef
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137
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|
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease, file dd9e0c65-f80f-1e9c-e053-3a05fe0a45ef
|
92
|
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Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c6c-2499-1e9c-e053-3a05fe0a45ef
|
89
|
|
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity, file dd9e0c67-ae48-1e9c-e053-3a05fe0a45ef
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72
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Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c6c-24fa-1e9c-e053-3a05fe0a45ef
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64
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Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease, file 7fb11c95-4318-4948-bfdb-f470f419ff1e
|
63
|
|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c6c-8224-1e9c-e053-3a05fe0a45ef
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61
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|
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity, file 2f0739a3-e288-42c7-8c5c-ad7778bfba68
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57
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In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors, file dd9e0c6c-2bcb-1e9c-e053-3a05fe0a45ef
|
54
|
|
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors, file dd9e0c6c-2bc6-1e9c-e053-3a05fe0a45ef
|
51
|
|
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties, file dd9e0c67-5731-1e9c-e053-3a05fe0a45ef
|
44
|
|
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase, file dd9e0c6c-87fe-1e9c-e053-3a05fe0a45ef
|
42
|
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Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif, file dd9e0c67-85a9-1e9c-e053-3a05fe0a45ef
|
39
|
|
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation, file dd9e0c6c-4f18-1e9c-e053-3a05fe0a45ef
|
36
|
|
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease, file dd9e0c65-afdf-1e9c-e053-3a05fe0a45ef
|
30
|
|
A rational approach to elucidate human monoamine oxidase molecular selectivity, file dd9e0c6c-55d2-1e9c-e053-3a05fe0a45ef
|
26
|
|
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds, file dd9e0c6c-5422-1e9c-e053-3a05fe0a45ef
|
24
|
|
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase, file 60693fbf-1cb2-4e38-a541-aa0e4f5dae0d
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17
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|
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, file dd9e0c6c-3996-1e9c-e053-3a05fe0a45ef
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16
|
|
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads., file dd9e0c6a-8b0c-1e9c-e053-3a05fe0a45ef
|
14
|
|
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets, file dd9e0c68-b7a7-1e9c-e053-3a05fe0a45ef
|
12
|
|
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties, file dd9e0c67-8131-1e9c-e053-3a05fe0a45ef
|
10
|
|
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase, file dd9e0c62-a87a-1e9c-e053-3a05fe0a45ef
|
9
|
|
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs, file dd9e0c6c-5ef0-1e9c-e053-3a05fe0a45ef
|
9
|
|
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c62-a4f0-1e9c-e053-3a05fe0a45ef
|
6
|
|
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors, file dd9e0c62-84f3-1e9c-e053-3a05fe0a45ef
|
4
|
|
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3, file dd9e0c65-8d26-1e9c-e053-3a05fe0a45ef
|
4
|
|
Multitarget Therapeutic Leads for Alzheimer’s Disease: Quinolizidinyl Derivatives of Bi- and Tri-cyclic Systems as Dual Inhibitors of Cholinesterases and Abeta Aggregation, file dd9e0c67-5c4d-1e9c-e053-3a05fe0a45ef
|
4
|
|
Design, Synthesis, and Biological Evaluation of Imidazolyl Derivatives of 4,7-Disubstituted Coumarins as Selective Aromatase Inhibitors, file dd9e0c62-8126-1e9c-e053-3a05fe0a45ef
|
3
|
|
null, file dd9e0c64-5192-1e9c-e053-3a05fe0a45ef
|
3
|
|
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors, file dd9e0c65-8c00-1e9c-e053-3a05fe0a45ef
|
3
|
|
A rational approach to elucidate human monoamine oxidase molecular selectivity, file dd9e0c67-80b3-1e9c-e053-3a05fe0a45ef
|
3
|
|
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase, file dd9e0c67-85bb-1e9c-e053-3a05fe0a45ef
|
3
|
|
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease, file dd9e0c69-1f23-1e9c-e053-3a05fe0a45ef
|
3
|
|
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease, file dd9e0c6b-86ca-1e9c-e053-3a05fe0a45ef
|
3
|
|
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease, file 6cbd6177-b7eb-4853-a0eb-c81bad380b4a
|
2
|
|
null, file dd9e0c62-6913-1e9c-e053-3a05fe0a45ef
|
2
|
|
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile, file dd9e0c62-a8f3-1e9c-e053-3a05fe0a45ef
|
2
|
|
Mind the Gap ! A Journey towards Computational Toxicology, file dd9e0c63-6507-1e9c-e053-3a05fe0a45ef
|
2
|
|
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs, file dd9e0c64-9098-1e9c-e053-3a05fe0a45ef
|
2
|
|
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors, file dd9e0c67-1352-1e9c-e053-3a05fe0a45ef
|
2
|
|
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c67-150f-1e9c-e053-3a05fe0a45ef
|
2
|
|
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases, file dd9e0c67-3862-1e9c-e053-3a05fe0a45ef
|
2
|
|
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents, file dd9e0c67-58d1-1e9c-e053-3a05fe0a45ef
|
2
|
|
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease, file dd9e0c6a-950a-1e9c-e053-3a05fe0a45ef
|
2
|
|
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential, file dd9e0c6a-ce75-1e9c-e053-3a05fe0a45ef
|
2
|
|
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor, file 45a1d0fe-3a09-4017-b1df-a4a83fcbd502
|
1
|
|
Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease, file b53f6f6b-1a5b-4a49-93d1-19dd3032a4e4
|
1
|
|
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor, file dd9e0c62-84f8-1e9c-e053-3a05fe0a45ef
|
1
|
|
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity, file dd9e0c62-a814-1e9c-e053-3a05fe0a45ef
|
1
|
|
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors, file dd9e0c62-aa40-1e9c-e053-3a05fe0a45ef
|
1
|
|
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease, file dd9e0c66-02ee-1e9c-e053-3a05fe0a45ef
|
1
|
|
4-Hydroxycoumarins as Michael donors in asymmetric routes to polycyclic coumarins (microreview), file dd9e0c67-0a05-1e9c-e053-3a05fe0a45ef
|
1
|
|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e4-1e9c-e053-3a05fe0a45ef
|
1
|
|
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1, file dd9e0c67-44e5-1e9c-e053-3a05fe0a45ef
|
1
|
|
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance, file dd9e0c67-813d-1e9c-e053-3a05fe0a45ef
|
1
|
|
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors., file dd9e0c67-cdd5-1e9c-e053-3a05fe0a45ef
|
1
|
|
OPTIMIZATION OF COUMARIN-BASED MULTITARGET LIGANDS: DISCOVERY OF POTENT WATER-SOLUBLE AND BRAINPERMEANT NEUROPROTECTIVE AChE-MAO B INHIBITORS, file dd9e0c68-b817-1e9c-e053-3a05fe0a45ef
|
1
|
|
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors, file dd9e0c68-ddff-1e9c-e053-3a05fe0a45ef
|
1
|
|
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease., file dd9e0c6a-6d8d-1e9c-e053-3a05fe0a45ef
|
1
|
|
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease., file dd9e0c6a-8b0e-1e9c-e053-3a05fe0a45ef
|
1
|
|
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets., file dd9e0c6a-b62a-1e9c-e053-3a05fe0a45ef
|
1
|
|
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE), file dd9e0c6c-06fc-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
1.146 |