IRIS
DESAPHY, Jean Francois
 Distribuzione geografica
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Continente #
NA - Nord America 10.907
AS - Asia 4.496
EU - Europa 3.028
SA - Sud America 1.290
AF - Africa 209
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 2
Totale 19.943
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Nazione #
US - Stati Uniti d'America 10.737
SG - Singapore 1.920
BR - Brasile 1.049
CN - Cina 1.007
HK - Hong Kong 527
SE - Svezia 484
RU - Federazione Russa 446
DE - Germania 410
IT - Italia 407
FR - Francia 298
VN - Vietnam 295
UA - Ucraina 276
FI - Finlandia 263
GB - Regno Unito 213
IN - India 160
BD - Bangladesh 105
ID - Indonesia 93
AR - Argentina 92
CA - Canada 71
CI - Costa d'Avorio 59
IQ - Iraq 55
MX - Messico 53
TR - Turchia 52
ZA - Sudafrica 42
NL - Olanda 38
EC - Ecuador 35
PL - Polonia 35
BE - Belgio 34
JP - Giappone 34
PK - Pakistan 30
VE - Venezuela 30
ES - Italia 29
CO - Colombia 28
SA - Arabia Saudita 26
IE - Irlanda 20
UZ - Uzbekistan 20
AT - Austria 19
PH - Filippine 19
EG - Egitto 18
MA - Marocco 18
CL - Cile 16
MY - Malesia 16
NP - Nepal 16
PY - Paraguay 16
JO - Giordania 15
TN - Tunisia 15
CR - Costa Rica 13
IR - Iran 13
KE - Kenya 12
ET - Etiopia 11
KZ - Kazakistan 11
AE - Emirati Arabi Uniti 10
LT - Lituania 10
DO - Repubblica Dominicana 9
AU - Australia 8
DZ - Algeria 8
KR - Corea 8
OM - Oman 8
PE - Perù 8
AL - Albania 7
IL - Israele 7
LB - Libano 7
UY - Uruguay 7
CZ - Repubblica Ceca 6
JM - Giamaica 6
AZ - Azerbaigian 5
BO - Bolivia 5
LY - Libia 5
PS - Palestinian Territory 5
TH - Thailandia 5
TT - Trinidad e Tobago 5
AM - Armenia 4
CH - Svizzera 4
HN - Honduras 4
KG - Kirghizistan 4
PA - Panama 4
SN - Senegal 4
AO - Angola 3
CG - Congo 3
HU - Ungheria 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PT - Portogallo 3
RO - Romania 3
RS - Serbia 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
BG - Bulgaria 2
DK - Danimarca 2
GA - Gabon 2
GE - Georgia 2
GY - Guiana 2
KW - Kuwait 2
LK - Sri Lanka 2
LV - Lettonia 2
MT - Malta 2
MU - Mauritius 2
NI - Nicaragua 2
QA - Qatar 2
SR - Suriname 2
Totale 19.920
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Città #
Fairfield 1.155
Ashburn 1.067
Singapore 995
Chandler 778
Woodbridge 747
Houston 618
Jacksonville 610
Hong Kong 524
San Jose 475
Cambridge 435
Seattle 424
Dallas 419
Wilmington 387
Nyköping 385
Ann Arbor 373
Beijing 292
Lauterbourg 182
Roxbury 167
Lawrence 166
Los Angeles 161
Bari 160
New York 152
Nanjing 147
Princeton 114
Des Moines 104
Boardman 99
Ho Chi Minh City 97
Helsinki 88
Inglewood 88
São Paulo 88
Council Bluffs 83
Santa Clara 82
San Diego 72
Abidjan 57
Hanoi 54
Jakarta 53
Buffalo 49
Brooklyn 45
London 44
Shenyang 43
Hebei 42
Jiaxing 41
Munich 38
Nanchang 37
Dong Ket 34
Falkenstein 33
Moscow 32
Brussels 31
Chicago 31
Brasília 30
Chennai 30
Dearborn 29
Tokyo 29
Rio de Janeiro 28
Warsaw 28
Frankfurt am Main 27
Turku 27
Montreal 25
San Francisco 23
Tianjin 23
Changsha 22
Dhaka 22
Nuremberg 22
Atlanta 21
Curitiba 20
Falls Church 20
Johannesburg 20
Paris 20
Pune 20
Toronto 20
Baghdad 19
San Mateo 19
Washington 19
Dublin 18
Guangzhou 18
Salvador 18
Stockholm 18
The Dalles 18
Orem 17
Phoenix 16
Ankara 15
Belo Horizonte 15
Denver 15
Grottaglie 15
Guayaquil 15
Poplar 15
Tashkent 15
Jinan 14
Amman 13
Amsterdam 13
Charlotte 13
Columbus 13
Manchester 13
Mexico City 13
Milan 13
Mumbai 13
Shanghai 13
Montignoso 12
Wuhan 12
Augusta 11
Totale 13.355
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Nome #
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 238
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 233
ClC-1 chloride channels: state-of-the-art research and future challenges 216
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 209
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 203
Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate 197
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 196
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 196
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 191
Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita 188
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 187
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 184
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 184
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 180
Characterization of Student Drinking Behaviors at the Beginning of the First Academic Year at One University in Southern Italy 180
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission 178
A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene. 172
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia 164
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within CBS2 domain and C-terminal peptide of ClC-1 channel 163
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 161
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 160
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 160
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 159
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 154
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 152
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels 150
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 149
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 145
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation 143
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 140
Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading 140
Antioxidant treatment of hindlimb-unloaded mouse in vivo counteracts fiber type transition but not atrophy of disused skeletal muscles 134
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 134
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 132
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 132
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 132
Redox homeostasis, oxidative stress and disuse muscle atrophy 131
Inhibitory effect of internal sodium and Hepes on the voltage-dependent potassium conductance of rat Leydig cells 127
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 127
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 126
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 124
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 122
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 122
18. Desaphy J.-F., De Luca A., George A.L. Jr. and D. Conte Camerino. Improved block of human skeletal muscle Na+ channel mutants by a new mexiletine derivative 121
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 121
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 121
Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes. 120
In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia 119
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 119
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 119
Emerging roles for ion channels in ovarian cancer: Pathomechanisms and pharmacological treatment 119
Taurine and skeletal muscle ion channels 118
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 118
Functional characterization of a C-terminal Nav1.4 mutation found in a patient presenting with myotonia and congenital myasthenia syndrome 116
Chaperone activity of niflumic acid on ClC-1 chloride channel mutants causing myotonia congenita 115
Muscle loading modulates aquaporin-4 expression in skeletal muscle 114
Age-dependent effects of disuse on electrophysiogical parameters and calcium homeostasis in the soleus muscle of hindlimb-unloaded mice 114
Effect of Mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita 114
Swelling and cAMP on hyperpolarization-activated Cl- conductance in rat Leydig cells 113
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 113
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 110
Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy 110
Effect of cyclic AMP on the calcium-dependent potassium conductances of rat Leydig cells 109
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 109
Autonomic nervous response following rat hindlimb unloading: Investigation on some peripheral districts 108
Taurine and skeletal muscle disorders 108
Skeletal muscle ClC-1 chloride channels in health and diseases 108
ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells 106
Editorial: Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 104
Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy 103
Ion channels gene expression analysis in myotonia congenita patients carrying ClC-1 chloride channel mutations 103
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 103
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 103
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 102
Effect of rat hindlimb suspension on cable properties, ionic conductances and fiber type composition of slow-twitch muscle. 100
Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia 100
Missense and Non-Missense Lamin A/C Gene Mutations Are Similarly Associated with Major Arrhythmic Cardiac Events: A 20-Year Single-Centre Experience 99
Biophysical characterization of hClC-1 chloride channel mutations associated with myotonia congenita 98
Effect of microgravity on gene expression in mouse brain 98
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 98
Anti-Angiogenic Activity of Drugs in Multiple Myeloma 98
Aromatic substituents on mexiletine chiral atom increase antimyotonic effect in vitro and in vivo 97
Drug repurposing in skeletal muscle ion channelopathies 95
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 95
Ion Channel Involvement in Tumor Drug Resistance 95
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 94
Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 94
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 93
Therapeutic approaches to ion channel diseases 93
Musculoskeletal Features without Ataxia Associated with a Novel de novo Mutation in KCNA1 Impairing the Voltage Sensitivity of Kv1.1 Channel 93
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 92
Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels 92
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 92
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 91
Structure-activity relationships in the sodium channel blocking activity of mexiletine analogues 91
Preclinical in vitro and in vivo evaluation of sodium channel blockers as possible alternative to mexiletine in the treatment of myotonia 91
null 90
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 90
Targeted Therapies for Skeletal Muscle Ion Channelopathies: Systematic Review and Steps Towards Precision Medicine 90
Immersive and Non-Immersive Virtual Reality for Pain and Anxiety Management in Pediatric Patients with Hematological or Solid Cancer: A Systematic Review 89
Totale 12.943
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Categoria #
all - tutte 84.301
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 84.301
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021596 0 0 0 0 0 0 0 0 0 289 178 129
2021/20221.302 53 183 8 94 57 76 48 64 89 102 211 317
2022/20232.082 303 185 139 200 228 303 22 261 332 12 52 45
2023/2024663 43 140 42 66 65 165 23 15 9 18 23 54
2024/20253.405 110 47 263 106 183 270 367 329 170 156 465 939
2025/20266.333 985 360 709 733 770 403 843 225 783 522 0 0
Totale 20.550