IRIS
DESAPHY, Jean Francois
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.899
AS - Asia 3.616
EU - Europa 2.577
SA - Sud America 1.079
AF - Africa 128
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 2
Totale 17.310
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 9.772
SG - Singapore 1.606
BR - Brasile 947
CN - Cina 923
HK - Hong Kong 500
SE - Svezia 483
RU - Federazione Russa 436
DE - Germania 364
IT - Italia 310
UA - Ucraina 271
FI - Finlandia 210
VN - Vietnam 208
GB - Regno Unito 204
FR - Francia 103
IN - India 85
ID - Indonesia 73
CA - Canada 58
CI - Costa d'Avorio 57
AR - Argentina 51
BD - Bangladesh 40
MX - Messico 39
BE - Belgio 34
PL - Polonia 32
TR - Turchia 31
NL - Olanda 29
IQ - Iraq 28
ZA - Sudafrica 24
ES - Italia 23
JP - Giappone 23
EC - Ecuador 20
AT - Austria 19
IE - Irlanda 18
VE - Venezuela 15
IR - Iran 12
CO - Colombia 11
PY - Paraguay 11
AE - Emirati Arabi Uniti 10
EG - Egitto 10
MA - Marocco 10
LT - Lituania 9
KR - Corea 8
CL - Cile 7
DO - Repubblica Dominicana 7
KZ - Kazakistan 7
PE - Perù 7
SA - Arabia Saudita 7
UZ - Uzbekistan 7
AU - Australia 6
CR - Costa Rica 6
CZ - Repubblica Ceca 6
IL - Israele 6
JO - Giordania 6
KE - Kenya 6
NP - Nepal 6
TN - Tunisia 6
UY - Uruguay 6
AL - Albania 5
PK - Pakistan 5
DZ - Algeria 4
PA - Panama 4
TT - Trinidad e Tobago 4
AM - Armenia 3
BO - Bolivia 3
JM - Giamaica 3
NZ - Nuova Zelanda 3
OM - Oman 3
AZ - Azerbaigian 2
BG - Bulgaria 2
CG - Congo 2
CH - Svizzera 2
DK - Danimarca 2
ET - Etiopia 2
LV - Lettonia 2
MY - Malesia 2
NI - Nicaragua 2
PH - Filippine 2
PT - Portogallo 2
QA - Qatar 2
RO - Romania 2
SN - Senegal 2
SY - Repubblica araba siriana 2
AO - Angola 1
BB - Barbados 1
BH - Bahrain 1
BY - Bielorussia 1
DM - Dominica 1
EE - Estonia 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
HU - Ungheria 1
KG - Kirghizistan 1
KN - Saint Kitts e Nevis 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
LY - Libia 1
Totale 17.299
Salva come PNG Salva come JPEG
Città #
Fairfield 1.155
Ashburn 950
Chandler 778
Singapore 778
Woodbridge 747
Houston 615
Jacksonville 610
Hong Kong 499
Cambridge 435
Seattle 424
Dallas 416
Wilmington 386
Nyköping 385
Ann Arbor 373
Beijing 284
Roxbury 167
Lawrence 166
Los Angeles 150
Nanjing 146
Bari 139
New York 139
Princeton 114
Des Moines 103
Boardman 97
Inglewood 88
São Paulo 77
Ho Chi Minh City 72
San Diego 72
Santa Clara 66
Abidjan 55
Jakarta 51
Buffalo 47
London 44
Shenyang 43
Hebei 42
Jiaxing 41
Brooklyn 40
Munich 38
Nanchang 37
Helsinki 35
Dong Ket 34
Hanoi 32
Brussels 31
Moscow 30
Dearborn 29
Chicago 28
Turku 27
Rio de Janeiro 26
Warsaw 26
Brasília 24
Chennai 23
Tianjin 23
Changsha 22
San Francisco 21
Falls Church 20
Curitiba 19
Montreal 19
Nuremberg 19
Paris 19
San Mateo 19
Tokyo 19
Washington 19
Guangzhou 18
Pune 18
Toronto 18
Salvador 17
Stockholm 17
Council Bluffs 16
Dublin 16
Johannesburg 16
Belo Horizonte 15
Denver 15
Frankfurt am Main 15
Grottaglie 15
Poplar 15
The Dalles 15
Columbus 13
Dhaka 13
Phoenix 13
Shanghai 13
Atlanta 12
Charlotte 12
Jinan 12
Montignoso 12
Wuhan 12
Amsterdam 11
Ankara 11
Augusta 11
Kunming 11
Ardabil 10
Caxias do Sul 10
Falkenstein 10
Fortaleza 10
Manchester 10
Milan 10
North Bergen 10
Santo André 10
Boston 9
Campinas 9
Guayaquil 9
Totale 11.922
Salva come PNG Salva come JPEG
Nome #
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 217
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 206
ClC-1 chloride channels: state-of-the-art research and future challenges 198
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 192
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 185
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 181
Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate 176
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 175
Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita 175
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 170
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 169
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission 166
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 164
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 162
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 161
Characterization of Student Drinking Behaviors at the Beginning of the First Academic Year at One University in Southern Italy 161
A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene. 157
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia 153
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 150
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 146
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 145
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 139
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within CBS2 domain and C-terminal peptide of ClC-1 channel 137
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 137
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 136
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels 134
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 132
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation 131
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 130
Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading 126
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 121
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 121
Redox homeostasis, oxidative stress and disuse muscle atrophy 120
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 120
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 117
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 115
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 114
Inhibitory effect of internal sodium and Hepes on the voltage-dependent potassium conductance of rat Leydig cells 113
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 113
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 113
Taurine and skeletal muscle ion channels 112
18. Desaphy J.-F., De Luca A., George A.L. Jr. and D. Conte Camerino. Improved block of human skeletal muscle Na+ channel mutants by a new mexiletine derivative 111
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 111
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 110
In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia 109
Swelling and cAMP on hyperpolarization-activated Cl- conductance in rat Leydig cells 108
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 108
Muscle loading modulates aquaporin-4 expression in skeletal muscle 107
Functional characterization of a C-terminal Nav1.4 mutation found in a patient presenting with myotonia and congenital myasthenia syndrome 107
Effect of Mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita 107
Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes. 106
Antioxidant treatment of hindlimb-unloaded mouse in vivo counteracts fiber type transition but not atrophy of disused skeletal muscles 104
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 104
Effect of cyclic AMP on the calcium-dependent potassium conductances of rat Leydig cells 103
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 103
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 102
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 101
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 100
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 99
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 98
Taurine and skeletal muscle disorders 98
Age-dependent effects of disuse on electrophysiogical parameters and calcium homeostasis in the soleus muscle of hindlimb-unloaded mice 98
Editorial: Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 97
Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy 97
Autonomic nervous response following rat hindlimb unloading: Investigation on some peripheral districts 95
Chaperone activity of niflumic acid on ClC-1 chloride channel mutants causing myotonia congenita 94
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 93
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 91
null 90
Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 90
Skeletal muscle ClC-1 chloride channels in health and diseases 90
Ion channels gene expression analysis in myotonia congenita patients carrying ClC-1 chloride channel mutations 89
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 89
Effect of rat hindlimb suspension on cable properties, ionic conductances and fiber type composition of slow-twitch muscle. 87
null 87
Aromatic substituents on mexiletine chiral atom increase antimyotonic effect in vitro and in vivo 86
Effect of microgravity on gene expression in mouse brain 86
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 86
Emerging roles for ion channels in ovarian cancer: Pathomechanisms and pharmacological treatment 86
Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy 86
Biophysical characterization of hClC-1 chloride channel mutations associated with myotonia congenita 85
Therapeutic approaches to ion channel diseases 85
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 84
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 84
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 84
Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia 84
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 83
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 83
Hydroxylation on the aromatic ring of mexiletine affects the block of voltage-gated sodium channels 82
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 82
Preclinical in vitro and in vivo evaluation of sodium channel blockers as possible alternative to mexiletine in the treatment of myotonia 81
Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels 81
ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells 80
Structure-activity relationships in the sodium channel blocking activity of mexiletine analogues 80
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 79
Drug repurposing in skeletal muscle ion channelopathies 78
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 78
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 78
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 78
Ion channel pharmacology 78
Totale 11.530
Salva come PNG Salva come JPEG
Categoria #
all - tutte 79.469
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 79.469
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.147 0 0 0 0 0 101 171 106 173 289 178 129
2021/20221.302 53 183 8 94 57 76 48 64 89 102 211 317
2022/20232.082 303 185 139 200 228 303 22 261 332 12 52 45
2023/2024663 43 140 42 66 65 165 23 15 9 18 23 54
2024/20253.405 110 47 263 106 183 270 367 329 170 156 465 939
2025/20263.700 985 360 709 733 770 143 0 0 0 0 0 0
Totale 17.917