IRIS
DESAPHY, Jean Francois
 Distribuzione geografica
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Continente #
NA - Nord America 9.952
AS - Asia 3.706
EU - Europa 2.604
SA - Sud America 1.099
AF - Africa 131
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 2
Totale 17.503
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Nazione #
US - Stati Uniti d'America 9.819
SG - Singapore 1.642
BR - Brasile 957
CN - Cina 931
HK - Hong Kong 506
SE - Svezia 483
RU - Federazione Russa 437
DE - Germania 364
IT - Italia 331
UA - Ucraina 272
VN - Vietnam 236
FI - Finlandia 210
GB - Regno Unito 204
FR - Francia 103
IN - India 89
ID - Indonesia 74
CA - Canada 61
CI - Costa d'Avorio 57
AR - Argentina 54
MX - Messico 42
BD - Bangladesh 41
BE - Belgio 34
PL - Polonia 33
NL - Olanda 31
TR - Turchia 31
IQ - Iraq 30
ZA - Sudafrica 25
ES - Italia 23
JP - Giappone 23
EC - Ecuador 21
AT - Austria 19
IE - Irlanda 18
VE - Venezuela 17
CO - Colombia 12
IR - Iran 12
PY - Paraguay 12
AE - Emirati Arabi Uniti 10
EG - Egitto 10
LT - Lituania 10
MA - Marocco 10
CL - Cile 9
KE - Kenya 8
KR - Corea 8
UZ - Uzbekistan 8
DO - Repubblica Dominicana 7
KZ - Kazakistan 7
PE - Perù 7
SA - Arabia Saudita 7
AU - Australia 6
CR - Costa Rica 6
CZ - Repubblica Ceca 6
IL - Israele 6
JO - Giordania 6
NP - Nepal 6
PK - Pakistan 6
TN - Tunisia 6
UY - Uruguay 6
AL - Albania 5
DZ - Algeria 4
PA - Panama 4
TT - Trinidad e Tobago 4
AM - Armenia 3
BO - Bolivia 3
JM - Giamaica 3
NZ - Nuova Zelanda 3
OM - Oman 3
AZ - Azerbaigian 2
BG - Bulgaria 2
CG - Congo 2
CH - Svizzera 2
DK - Danimarca 2
ET - Etiopia 2
KG - Kirghizistan 2
LV - Lettonia 2
MY - Malesia 2
NI - Nicaragua 2
PH - Filippine 2
PT - Portogallo 2
QA - Qatar 2
RO - Romania 2
SN - Senegal 2
SY - Repubblica araba siriana 2
TW - Taiwan 2
AO - Angola 1
BB - Barbados 1
BH - Bahrain 1
BY - Bielorussia 1
DM - Dominica 1
EE - Estonia 1
EU - Europa 1
GA - Gabon 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
HR - Croazia 1
HU - Ungheria 1
KN - Saint Kitts e Nevis 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
LB - Libano 1
Totale 17.492
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Città #
Fairfield 1.155
Ashburn 963
Singapore 812
Chandler 778
Woodbridge 747
Houston 617
Jacksonville 610
Hong Kong 504
Cambridge 435
Seattle 424
Dallas 416
Wilmington 386
Nyköping 385
Ann Arbor 373
Beijing 284
Roxbury 167
Lawrence 166
Bari 156
Los Angeles 153
Nanjing 146
New York 142
Princeton 114
Des Moines 103
Boardman 97
Inglewood 88
Ho Chi Minh City 81
São Paulo 79
San Diego 72
Santa Clara 67
Abidjan 55
Jakarta 51
Buffalo 47
Brooklyn 44
London 44
Shenyang 43
Hebei 42
Jiaxing 41
Hanoi 38
Munich 38
Nanchang 37
Helsinki 35
Dong Ket 34
Brussels 31
Moscow 30
Chicago 29
Dearborn 29
Turku 27
Warsaw 27
Brasília 26
Rio de Janeiro 26
Chennai 24
Tianjin 23
Changsha 22
Montreal 22
San Francisco 21
Falls Church 20
Curitiba 19
Nuremberg 19
Paris 19
San Mateo 19
Tokyo 19
Washington 19
Guangzhou 18
Pune 18
Toronto 18
Johannesburg 17
Salvador 17
Stockholm 17
Council Bluffs 16
Dublin 16
Belo Horizonte 15
Denver 15
Frankfurt am Main 15
Grottaglie 15
Poplar 15
The Dalles 15
Charlotte 13
Columbus 13
Dhaka 13
Phoenix 13
Shanghai 13
Atlanta 12
Jinan 12
Montignoso 12
Wuhan 12
Amsterdam 11
Ankara 11
Augusta 11
Fortaleza 11
Kunming 11
Ardabil 10
Caxias do Sul 10
Falkenstein 10
Manchester 10
Mexico City 10
Milan 10
North Bergen 10
Orem 10
Santo André 10
Boston 9
Totale 12.034
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Nome #
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 218
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 209
ClC-1 chloride channels: state-of-the-art research and future challenges 199
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 192
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 186
Elucidating the Contribution of Skeletal Muscle Ion Channels to Amyotrophic Lateral Sclerosis in search of new therapeutic options 183
Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate 177
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 176
Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita 176
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 171
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 170
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission 167
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 166
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 164
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 163
Characterization of Student Drinking Behaviors at the Beginning of the First Academic Year at One University in Southern Italy 162
A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene. 159
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia 155
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 153
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 148
Risk of myopathy in patients in therapy with statins: Identification of biological markers in a pilot study 146
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 140
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 138
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within CBS2 domain and C-terminal peptide of ClC-1 channel 137
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 137
Effects of Benzothiazolamines on Voltage-Gated Sodium Channels 135
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 134
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation 131
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 131
Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading 127
A new benzylated proline-like tocainide derivative is a potent use-dependent skeletal muscle Na+ channel blocker with a potential anti-myotonic activity 123
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 122
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 122
Redox homeostasis, oxidative stress and disuse muscle atrophy 120
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 117
Inhibitory effect of internal sodium and Hepes on the voltage-dependent potassium conductance of rat Leydig cells 115
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 115
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 115
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 114
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 113
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 113
18. Desaphy J.-F., De Luca A., George A.L. Jr. and D. Conte Camerino. Improved block of human skeletal muscle Na+ channel mutants by a new mexiletine derivative 112
Taurine and skeletal muscle ion channels 112
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 111
In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia 110
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 109
Functional characterization of a C-terminal Nav1.4 mutation found in a patient presenting with myotonia and congenital myasthenia syndrome 109
Effect of Mexiletine on transitory depression of compound motor action potential in recessive myotonia congenita 109
Swelling and cAMP on hyperpolarization-activated Cl- conductance in rat Leydig cells 108
Muscle loading modulates aquaporin-4 expression in skeletal muscle 108
Antioxidant treatment of hindlimb-unloaded mouse in vivo counteracts fiber type transition but not atrophy of disused skeletal muscles 107
Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes. 107
Effect of cyclic AMP on the calcium-dependent potassium conductances of rat Leydig cells 104
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 104
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 104
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 104
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 102
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 101
Effects of GH secretagogues on resting chloride conductance of aged rat skeletal muscle 101
Age-dependent effects of disuse on electrophysiogical parameters and calcium homeostasis in the soleus muscle of hindlimb-unloaded mice 101
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 98
Taurine and skeletal muscle disorders 98
Editorial: Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 97
Dramatic improvement of myotonia permanens with flecainide: a two-case report of a possible bench-to-bedside pharmacogenetics strategy 97
Chaperone activity of niflumic acid on ClC-1 chloride channel mutants causing myotonia congenita 96
Autonomic nervous response following rat hindlimb unloading: Investigation on some peripheral districts 96
Increased sarcolemma chloride conductance as one of the mechanisms of action of carbonic anhydrase inhibitors in muscle excitability disorders 95
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 91
Skeletal muscle ClC-1 chloride channels in health and diseases 91
An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function 91
null 90
Effect of rat hindlimb suspension on cable properties, ionic conductances and fiber type composition of slow-twitch muscle. 90
Recent advances in voltage-gated sodium channels, their pharmacology and related diseases 90
Ion channels gene expression analysis in myotonia congenita patients carrying ClC-1 chloride channel mutations 90
Emerging roles for ion channels in ovarian cancer: Pathomechanisms and pharmacological treatment 88
Ion Channel Gene Mutations Causing Skeletal Muscle Disorders: Pathomechanisms and Opportunities for Therapy 88
Aromatic substituents on mexiletine chiral atom increase antimyotonic effect in vitro and in vivo 87
null 87
Biophysical characterization of hClC-1 chloride channel mutations associated with myotonia congenita 86
Effect of microgravity on gene expression in mouse brain 86
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 86
Therapeutic approaches to ion channel diseases 85
Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat 84
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 84
Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance 84
Potential targets for skeletal muscle impairment by hypogravity: basic characterization of resting ionic conductances and mechanical threshold of rat fast- and slow-twitch muscle fibers 84
Different ability of clenbuterol and salbutamol to block sodium channels predicts their therapeutic use in muscle excitability disorders 84
Pathomechanisms of a CLCN1 Mutation Found in a Russian Family Suffering From Becker's Myotonia 84
ECM Composition Differentially Regulates Intracellular and Extracellular pH in Normal and Cancer Pancreatic Duct Epithelial Cells 83
Hydroxylation on the aromatic ring of mexiletine affects the block of voltage-gated sodium channels 83
Comparison of excitability parameters and sodium channel behavior of fast- and slow-twitch rat skeletal muscles for the study of the effects of hindlimb suspension, a model of hypogravity. 82
Preclinical in vitro and in vivo evaluation of sodium channel blockers as possible alternative to mexiletine in the treatment of myotonia 82
Structure-activity relationships in the sodium channel blocking activity of mexiletine analogues 81
Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels 81
Effects of Pleiotrophin Overexpression on Mouse Skeletal Muscles in Normal Loading and in Actual and Simulated Microgravity 81
Drug repurposing in skeletal muscle ion channelopathies 80
Anti-Angiogenic Activity of Drugs in Multiple Myeloma 80
Molecular determinants in mexiletine and tocainide structure to improve therapy of myotonia 78
High affinity block of skeletal muscle sodium channels by newly synthesized analogs of tocainide and its proline-like derivatives 78
Skeletal muscle disuse fiber type-dependent enhancement of Na+ channel expression 78
Totale 11.636
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Categoria #
all - tutte 80.480
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.480
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.147 0 0 0 0 0 101 171 106 173 289 178 129
2021/20221.302 53 183 8 94 57 76 48 64 89 102 211 317
2022/20232.082 303 185 139 200 228 303 22 261 332 12 52 45
2023/2024663 43 140 42 66 65 165 23 15 9 18 23 54
2024/20253.405 110 47 263 106 183 270 367 329 170 156 465 939
2025/20263.893 985 360 709 733 770 336 0 0 0 0 0 0
Totale 18.110