IRIS
CONTE, Diana
 Distribuzione geografica
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Continente #
NA - Nord America 16.420
EU - Europa 3.532
AS - Asia 1.963
SA - Sud America 50
AF - Africa 8
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 6
Totale 21.986
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Nazione #
US - Stati Uniti d'America 16.385
CN - Cina 1.273
SE - Svezia 806
UA - Ucraina 636
SG - Singapore 533
DE - Germania 495
FI - Finlandia 366
IT - Italia 357
RU - Federazione Russa 322
GB - Regno Unito 256
FR - Francia 132
BE - Belgio 72
IN - India 50
BR - Brasile 38
IE - Irlanda 37
VN - Vietnam 37
CA - Canada 34
IR - Iran 19
CZ - Repubblica Ceca 14
NL - Olanda 14
JP - Giappone 13
HK - Hong Kong 12
LT - Lituania 7
CL - Cile 6
KR - Corea 6
TR - Turchia 6
EU - Europa 5
AT - Austria 4
AU - Australia 4
EG - Egitto 4
ID - Indonesia 4
AR - Argentina 3
CH - Svizzera 3
DK - Danimarca 3
A1 - Anonimo 2
BG - Bulgaria 2
MA - Marocco 2
NZ - Nuova Zelanda 2
PH - Filippine 2
AE - Emirati Arabi Uniti 1
BD - Bangladesh 1
EC - Ecuador 1
EE - Estonia 1
ES - Italia 1
IL - Israele 1
KE - Kenya 1
LB - Libano 1
LV - Lettonia 1
MX - Messico 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
PT - Portogallo 1
QA - Qatar 1
RO - Romania 1
TH - Thailandia 1
TW - Taiwan 1
UY - Uruguay 1
VE - Venezuela 1
Totale 21.986
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Città #
Fairfield 2.365
Woodbridge 1.572
Jacksonville 1.391
Ashburn 1.376
Chandler 1.360
Houston 1.125
Seattle 901
Cambridge 872
Wilmington 772
Ann Arbor 726
Nyköping 608
Singapore 410
Lawrence 336
Roxbury 336
Nanjing 334
Princeton 265
Boardman 215
Des Moines 214
Beijing 185
New York 155
Bari 153
Inglewood 139
San Diego 122
Shenyang 90
Nanchang 87
Jiaxing 82
Hebei 74
Brussels 69
Los Angeles 64
Santa Clara 55
London 54
Tianjin 51
Helsinki 44
Dearborn 42
Changsha 40
Falls Church 38
Dublin 37
Dong Ket 36
Guangzhou 29
Pune 28
San Mateo 24
Shanghai 24
Jinan 23
Wuhan 23
Brooklyn 22
Monmouth Junction 21
Norwalk 21
Toronto 20
Paris 18
Ardabil 17
Zhengzhou 17
Ningbo 16
Redwood City 16
Kunming 15
Brno 14
Augusta 13
Hefei 13
Indiana 13
Tappahannock 13
Leawood 12
Washington 12
Hong Kong 10
Kilburn 10
Milan 10
Genova 9
Prescot 9
San Francisco 9
Chiswick 8
Ottawa 8
Hounslow 7
Islington 7
Montignoso 7
Tokyo 7
Chicago 6
Munich 6
Quanzhou 6
Shenzhen 6
Acton 5
Auburn Hills 5
Jinhua 5
Marseille 5
Rome 5
São Paulo 5
Taranto 5
Wuxi 5
Campobello Di Mazara 4
Chongqing 4
Frankfurt am Main 4
Hangzhou 4
Mottola 4
Mumbai 4
New Bedfont 4
Phoenix 4
Sannicandro di Bari 4
Simi Valley 4
Taizhou 4
Altamura 3
Belém 3
Brasília 3
Clichy 3
Totale 17.440
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 414
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 162
ClC-1 chloride channels: state-of-the-art research and future challenges 154
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 142
Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate 142
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 137
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 134
Ion channels in drug discovery and safety pharmacology 133
Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita 132
Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels 128
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 126
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission 125
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 123
Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats 121
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 120
Recent advances in the pathogenesis and drug action in periodic paralyses and related channelopathies 119
Activation and inhibition of kidney CLC-K chloride channels by fenamates 117
Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in the hypokalemic periodic paralysis 115
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 115
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within CBS2 domain and C-terminal peptide of ClC-1 channel 114
A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene. 112
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 110
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia 110
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 110
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 109
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 108
Acetazolamide prevents vacuolar myopathy in skeletal muscle of K+-depleted rats 108
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 106
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 106
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 106
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 104
Redox homeostasis, oxidative stress and disuse muscle atrophy 102
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 102
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 102
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 102
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 101
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 101
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 100
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 99
null 99
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 99
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 98
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 98
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 97
Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle 96
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 96
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 96
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 96
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 96
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 95
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 95
EFFETTI DEL DANTROLENE SODICO SUL MUSCOLO DETRUSORE DI VESCICA URINARIA ISOLATA DI CAVIA 93
In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia 93
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 93
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 93
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation 92
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 92
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties 92
Taurine and skeletal muscle ion channels 91
null 91
null 90
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 90
EFFECTS OF VINBLASTINE ON THE COMPONENT CONDUCTANCES OF RAT SKELETAL MUSCLE FIBERS 89
Changes of chloride channel regulation in rat skeletal muscle during aging 89
Acetazolamide opens the muscular K(Ca)2+ channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis 89
Dual response of the KATP channels to staurosporine: a novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes 87
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 87
null 87
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 86
Enantiomeric effects on excitation-contraction coupling in frog skeletal muscle by a chiral phenoxy carboxylic acid 86
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 86
null 86
Involvement of K(Ca2+)channels in the local abnormalities and hyperkalemia following the ischemia-reperfusion injury of rat skeletal muscle 86
Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading 86
Aging and chloride channel regulation in rat fast-twitch muscle fibres 85
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 84
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 84
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 84
Muscle loading modulates aquaporin-4 expression in skeletal muscle 83
Involvement of 3Na+/2K+ ATP-ase and Pi-3 kinase in the response of skeletal muscle ATP-sensitive K+ channels to insulin 83
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 83
Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium 83
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 82
Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+ - deficient rats 82
Taurine blocks ATP-sensitive potassium channels of rat skeletal muscle fibres interfering with the sulphonylurea receptor 81
Developmental changes of membrane electrical properties of rat skeletal muscle fibers produced by prenatal exposure to carbon monoxide 81
Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block 80
Molecular determinants of differential pore blocking of kidney CLC-K chloride channels 80
Comparative evaluation of the effects of lidocaine (lignocaine) hydrochloride and salicylate on nervous and Purkinje fibres 80
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 80
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 80
CILIARY MUSCLE RECEPTORS OF FRESH HUMAN EYES 79
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
Effects of mexiletine on ATP sensitive K+ channel of rat skeletal muscle fibres: a state dependent mechanism of action 78
Insulin modulation of ATP-sensitive K+ channel of rat skeletal muscle is impaired in the hypokalaemic state 78
PHARMACOLOGICAL BLOCK OF CHLORIDE CHANNELS DURING DEVELOPMENT AFFECTS CONTRACTILE AND ELECTRICAL-PROPERTIES OF RAT SKELETAL-MUSCLE 78
Effects of Acetazolamide on alpha subunit of human BK channel expressed in HEK293 cells 77
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 77
Stereospecific effects of tocainide and its chiral derivatives on rat skeletal muscle sodium channel. 77
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 77
Totale 10.181
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Categoria #
all - tutte 101.416
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 101.416
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.561 0 0 0 0 0 0 592 450 664 255 466 134
2020/20213.585 426 272 317 292 319 152 271 179 331 506 305 215
2021/20222.535 89 488 19 158 135 141 145 124 154 153 368 561
2022/20233.778 652 269 224 362 479 526 20 426 636 21 74 89
2023/20241.483 101 254 62 85 109 256 159 287 7 32 14 117
2024/20251.376 144 86 469 144 131 398 4 0 0 0 0 0
Totale 22.548