IRIS
CONTE, Diana
 Distribuzione geografica
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Continente #
NA - Nord America 20.523
AS - Asia 7.607
EU - Europa 6.092
SA - Sud America 2.062
AF - Africa 233
OC - Oceania 12
Continente sconosciuto - Info sul continente non disponibili 8
Totale 36.537
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Nazione #
US - Stati Uniti d'America 20.257
SG - Singapore 3.304
CN - Cina 1.815
IT - Italia 1.770
BR - Brasile 1.665
HK - Hong Kong 934
SE - Svezia 819
UA - Ucraina 665
RU - Federazione Russa 624
DE - Germania 589
FR - Francia 494
FI - Finlandia 458
VN - Vietnam 391
GB - Regno Unito 363
BD - Bangladesh 265
IN - India 232
AR - Argentina 135
CA - Canada 124
IQ - Iraq 89
ID - Indonesia 86
BE - Belgio 75
TR - Turchia 65
MX - Messico 64
EC - Ecuador 61
CO - Colombia 56
ZA - Sudafrica 56
PK - Pakistan 52
JP - Giappone 51
VE - Venezuela 45
SA - Arabia Saudita 44
IE - Irlanda 41
CL - Cile 36
NL - Olanda 34
MA - Marocco 32
ES - Italia 31
UZ - Uzbekistan 31
CI - Costa d'Avorio 29
IR - Iran 25
MY - Malesia 25
PL - Polonia 25
PH - Filippine 24
KE - Kenya 23
NP - Nepal 22
TN - Tunisia 22
PY - Paraguay 21
JO - Giordania 19
AE - Emirati Arabi Uniti 18
AT - Austria 18
EG - Egitto 18
CR - Costa Rica 17
LT - Lituania 17
UY - Uruguay 17
KR - Corea 15
CZ - Repubblica Ceca 14
ET - Etiopia 14
PE - Perù 14
AL - Albania 13
IL - Israele 12
JM - Giamaica 12
KZ - Kazakistan 12
AU - Australia 10
DZ - Algeria 9
LB - Libano 9
OM - Oman 9
PA - Panama 9
BO - Bolivia 8
GE - Georgia 8
HN - Honduras 8
TT - Trinidad e Tobago 8
KG - Kirghizistan 7
PS - Palestinian Territory 7
TH - Thailandia 7
SN - Senegal 6
AO - Angola 5
AZ - Azerbaigian 5
EU - Europa 5
NG - Nigeria 5
NI - Nicaragua 5
SV - El Salvador 5
BH - Bahrain 4
CH - Svizzera 4
DK - Danimarca 4
DO - Repubblica Dominicana 4
GR - Grecia 4
KW - Kuwait 4
RO - Romania 4
RS - Serbia 4
AM - Armenia 3
BG - Bulgaria 3
DM - Dominica 3
GT - Guatemala 3
HU - Ungheria 3
NO - Norvegia 3
A1 - Anonimo 2
BB - Barbados 2
BN - Brunei Darussalam 2
EE - Estonia 2
LV - Lettonia 2
LY - Libia 2
MN - Mongolia 2
Totale 36.498
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Città #
Fairfield 2.365
Ashburn 2.003
Singapore 1.780
Woodbridge 1.573
Jacksonville 1.395
Chandler 1.354
Houston 1.141
Hong Kong 929
Seattle 917
San Jose 889
Cambridge 872
Milan 791
Wilmington 773
Ann Arbor 726
Nyköping 601
Dallas 528
Beijing 430
Roxbury 336
Nanjing 335
Lawrence 334
Lauterbourg 305
Princeton 263
New York 232
Rome 220
Boardman 217
Des Moines 215
Los Angeles 192
Bari 159
Ho Chi Minh City 147
Inglewood 139
Santa Clara 132
San Diego 122
São Paulo 119
Helsinki 115
Shenyang 91
Nanchang 87
Jiaxing 82
Buffalo 77
Hebei 74
London 73
Brussels 71
Columbus 70
Council Bluffs 65
Figino 60
Hanoi 60
Chicago 56
Rio de Janeiro 53
Tianjin 51
Turin 50
Brasília 47
Brooklyn 47
Baghdad 44
Munich 43
Dearborn 42
Changsha 41
Tokyo 41
San Francisco 39
Dublin 38
Falls Church 38
Belo Horizonte 36
Dong Ket 36
Pune 35
Toronto 34
Jakarta 33
Phoenix 33
The Dalles 32
Moscow 31
Atlanta 30
Guangzhou 29
Montreal 29
Abidjan 28
Shanghai 28
Frankfurt am Main 27
Mexico City 27
Wuhan 27
Naples 26
Chennai 25
Dhaka 25
Tashkent 25
Jinan 24
Paris 24
San Mateo 24
Johannesburg 23
Manchester 23
Medellín 23
Norwalk 23
Denver 22
Warsaw 22
Monmouth Junction 21
Orem 21
Turku 21
Curitiba 20
Stockholm 20
Washington 20
Poplar 19
Porto Alegre 19
Augusta 18
Campinas 18
Guayaquil 18
Ardabil 17
Totale 25.125
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Nome #
EFFECTS OF TAURINE DEPLETION ON EXCITATION-CONTRACTION COUPLING AND CL- CONDUCTANCES OF RAT SKELETAL MUSCLE. 466
The analysis of myotonia congenita mutations discloses functional clusters of amino acids within CBS2 domain and C-terminal peptide of ClC-1 channel 286
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine 249
Effects of Nandrolone in the counteraction of skeletal muscle atrophy in a mouse model of muscle disuse: molecular biology and functional evaluation 246
ClC-1 chloride channels: state-of-the-art research and future challenges 227
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 210
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 210
Antioxidant treatment of hindlimb-unloaded mouse counteracts fiber type transition but not atrophy of disused muscles 206
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 206
Clinical, Molecular, and Functional Characterization of CLCN1 Mutations in Three Families with Recessive Myotonia Congenita 203
Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate 203
Growth hormone secretagogues prevent dysregulation of skeletal muscle calcium homeostasis in a rat model of cisplatin-induced cachexia 202
In vivo longitudinal study of rodent skeletal muscle atrophy using ultrasonography 200
Increased sodium channel use-dependent inhibition by a new potent analogue of tocainide greatly enhances in vivo antimyotonic activity 197
Carbonic anhydrase inhibitors ameliorate the symptoms of hypokalaemic periodic paralysis in rats by opening the muscular Ca2+-activated-K+ channels 193
Acetazolamide prevents vacuolar myopathy in skeletal muscle of K+-depleted rats 193
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission 187
Activation and inhibition of kidney CLC-K chloride channels by fenamates 186
A large cohort of myotonia congenita probands: novel mutations and a high-frequency mutation region in exons 4 and 5 of the CLCN1 gene. 184
Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models 183
Alteration of excitation-contraction coupling mechanism in extensor digitorum longus muscle fibres of dystrophic mdx mouse and potential efficacy of taurine 183
Ion channels in drug discovery and safety pharmacology 183
Constrained analogues of tocainide as potent skeletal muscle sodium channel blockers towards the development of antimyotonic agents 174
Change of chloride ion channel conductance is an early event of slow-to-fast fibre type transition during unloading-induced muscle disuse 169
Coexistence of CLCN1 and SCN4A mutations in one family suffering from myotonia 166
Acetazolamide opens the muscular K(Ca)2+ channel: A novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis 164
Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats 164
Recent advances in the pathogenesis and drug action in periodic paralyses and related channelopathies 163
Acetazolamide opens the muscular KCa2+ channel: a novel mechanism of action that may explain the therapeutic effect of the drug in the hypokalemic periodic paralysis 162
Blockade by cAMP of native sodium channels of adult rat skeletal muscle fibers 162
Antimyotonic effects of tocainide enantiomers on skeletal muscle fibers of congenitally myotonic goats 162
Safinamide's potential in treating nondystrophic myotonias: Inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo 161
Aging and chloride channel regulation in rat fast-twitch muscle fibres 160
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 160
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 157
Aging-associated down-regulation of CLC-1 expression in skeletal muscle: phenotypic-independent relation to the decrease of chloride conductance 156
Translational approach to address therapy in myotonia permanens due to a new SCN4A mutation 156
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 156
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 155
Effect of taurine on excitation-contraction coupling of extensor digitorum longus muscle of dystrophic mdx mouse 154
A multidisciplinary evaluation of the effectiveness of cyclosporine A in dystrophic mdx mice 154
Electrical properties of diaphragm and EDL muscles during the life of dystrophic mice 153
The biophysical and pharmacological characteristics of skeletal muscle ATP-Sensitive K+ channels are modified in K+-depleted rat, an animal model of hypokalemic periodic paralysis 152
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers 148
Analysis by two-dimensional Blue Native/SDS-PAGE of membrane protein alterations in rat soleus muscle after hindlimb unloading 148
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 147
Changes of chloride channel regulation in rat skeletal muscle during aging 146
Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice 145
Pre-clinical trials in Duchenne dystrophy: what animal models can tell us about potential drug effectiveness 142
A stereospecific binding site regulates the C1- ion channel in rat skeletal muscle 142
Phosphorylation and IGF-1-mediated dephosphorylation pathways control the activity and the pharmacological properties of skeletal muscle chloride channels 141
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 141
Fiber type-related changes in rat skeletal muscle calcium homeostasis during aging and restoration by growth hormone 140
Carbonic anhydrase inhibitors are specific openers of skeletal muscle BK channel of K+ - deficient rats 140
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 140
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 139
Ciliary neurotrophic factor prevents unweighting-induced functional changes in rat soleus muscle 138
Effetti di una nuova 1-4 diidropiridina, il Bay K 8644, su organi a muscolatura liscia isolati di cavia 138
Antioxidant treatment of hindlimb-unloaded mouse in vivo counteracts fiber type transition but not atrophy of disused skeletal muscles 138
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 137
Redox homeostasis, oxidative stress and disuse muscle atrophy 136
Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives 135
Therapeutic approaches to genetic ion channelopathies and perspectives in drug discovery 135
Calcium homeostasis is altered in skeletal muscle of spontaneously hypertensive rats cytofluorimetric and gene expression analysis 134
Searching for novel anti-myotonic agents: Pharmacophore requirement for use-dependent block of skeletal muscle sodium channels by N-benzylated cyclic derivatives of tocainide 134
Enhanced dystrophic progression in mdx mice by exercise and beneficial effects of taurine and insulin-like growth factor-1 134
Chronic administration of taurine to aged rats improves the electrical and contractile properties of skeletal muscle fibers 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 132
Statins and fenofibrate affect skeletal muscle chloride conductance in rats by different impairing ClC-1 channel regulation and expression 131
Is oxidative stress a cause or consequence of disuse muscle atrophy in mice? A proteomic approach in hindlimb unloaded mice 129
Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile 129
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties 129
Effects of Acetazolamide on alpha subunit of human BK channel expressed in HEK293 cells 128
In vivo evaluation of antimyotonic efficacy of β-adrenergic drugs in a rat model of myotonia 128
Excitation-contraction coupling of extensor digitorum longus muscle of dystrophic MDX mouse 128
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 128
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 128
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 128
Splicing of the rSlo gene affects the molecular composition and drug response of Ca2+-activated K+ channels in skeletal muscle 128
Functional characterization of a C-terminal Nav1.4 mutation found in a patient presenting with myotonia and congenital myasthenia syndrome 127
Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium 127
Biophysical changes of skeletal muscle K-ATP channels in K+ depleted rats and pharmacological interventions. 126
Involvement of K(Ca2+)channels in the local abnormalities and hyperkalemia following the ischemia-reperfusion injury of rat skeletal muscle 126
Effect of HMG-CoA reductase inhibitors on excitation-contraction coupling of rat skeletal muscle 126
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ 126
EFFETTI DEL DANTROLENE SODICO SUL MUSCOLO DETRUSORE DI VESCICA URINARIA ISOLATA DI CAVIA 125
Dual response of the KATP channels to staurosporine: a novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes 125
Ion channels in muscle and cardiac hereditary diseases: from gene dysfunction to pharmacological therapy 125
Use-Dependent block of voltage-gated sodium channels by orphenadrine through binding at the local anesthetic receptor 125
Identification of sites responsible for the potentiating effect of niflumic acid on ClC-Ka kidney chloride channels 124
Changes of membrane electrical properties in extensor digitorum longus muscle from dystrophic (mdx) mice 123
Functional characterization of ClC-1 mutations from patients affected by recessive myotonia congenita presenting with different clinical phenotypes. 123
Taurine: the appeal of a safe amino acid for skeletal muscle disorders. 122
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 121
ALTERATIONS OF ELECTRICAL AND BIOCHEMICAL PARAMETERS OF ISCHEMIC AND REPERFUSED RAT SKELETAL-MUSCLE FIBERS 120
Antitumorali 120
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 120
EFFECTS OF VINBLASTINE ON THE COMPONENT CONDUCTANCES OF RAT SKELETAL MUSCLE FIBERS 119
Taurine and skeletal muscle ion channels 119
Totale 15.717
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Categoria #
all - tutte 159.612
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 159.612
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20222.535 89 488 19 158 135 141 145 124 154 153 368 561
2022/20233.757 648 266 222 360 477 523 20 423 634 21 74 89
2023/20241.476 101 253 62 84 109 252 159 287 7 31 14 117
2024/20254.958 143 85 467 144 130 396 318 469 247 249 732 1.578
2025/202610.739 1.377 485 868 1.078 1.000 552 1.393 312 906 945 359 1.464
2026/2027262 262 0 0 0 0 0 0 0 0 0 0 0
Totale 37.103