IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 9.487
EU - Europa 2.217
AS - Asia 1.324
OC - Oceania 8
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 4
AF - Africa 2
Totale 13.048
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Nazione #
US - Stati Uniti d'America 9.466
CN - Cina 865
SE - Svezia 564
UA - Ucraina 371
SG - Singapore 353
IT - Italia 342
DE - Germania 279
FI - Finlandia 215
GB - Regno Unito 168
FR - Francia 157
IN - India 46
BE - Belgio 32
IE - Irlanda 32
VN - Vietnam 24
CA - Canada 20
CH - Svizzera 12
NL - Olanda 10
IR - Iran 9
PT - Portogallo 9
AU - Australia 5
ID - Indonesia 5
RU - Federazione Russa 5
AT - Austria 4
KR - Corea 4
TR - Turchia 4
CL - Cile 3
CZ - Repubblica Ceca 3
JP - Giappone 3
LT - Lituania 3
NZ - Nuova Zelanda 3
A1 - Anonimo 2
BR - Brasile 2
EE - Estonia 2
EG - Egitto 2
ES - Italia 2
EU - Europa 2
HK - Hong Kong 2
IL - Israele 2
MY - Malesia 2
PL - Polonia 2
TH - Thailandia 2
AR - Argentina 1
BD - Bangladesh 1
BG - Bulgaria 1
DK - Danimarca 1
HR - Croazia 1
IM - Isola di Man 1
KH - Cambogia 1
MT - Malta 1
MX - Messico 1
TW - Taiwan 1
Totale 13.048
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Città #
Fairfield 1.164
Chandler 997
Woodbridge 901
Jacksonville 861
Ashburn 649
Houston 605
Cambridge 509
Seattle 456
Nyköping 442
Wilmington 378
Ann Arbor 371
Singapore 262
Roxbury 234
Lawrence 231
Nanjing 217
Princeton 149
Boardman 148
Beijing 139
Des Moines 132
New York 110
Bari 101
Inglewood 91
San Diego 61
Nanchang 55
Hebei 46
Dearborn 44
Brooklyn 43
Shenyang 43
Santa Clara 42
Jiaxing 41
Los Angeles 36
London 35
Changsha 34
Tianjin 34
Brussels 32
Dublin 32
Marseille 27
Paris 26
Munich 25
Washington 24
Dong Ket 23
Augusta 19
Guangzhou 19
Naples 17
Pune 17
Shanghai 17
Wuhan 17
Milan 16
Helsinki 15
Boydton 14
Jinan 13
Leawood 13
San Francisco 13
Redwood City 12
Toronto 12
Zhengzhou 11
Kilburn 10
Wuxi 10
Frankfurt am Main 9
Genova 9
Hefei 9
Monmouth Junction 9
Norwalk 9
Haikou 8
Lisbon 8
Shenzhen 8
Edinburgh 7
Lausanne 7
Ningbo 7
Salerno 7
Auburn Hills 6
Bitonto 6
Hounslow 6
Islington 6
San Mateo 6
Taizhou 6
Ardabil 5
Brindisi 5
Jinhua 5
Patna 5
Quanzhou 5
Tappahannock 5
Bologna 4
Chiswick 4
Florence 4
Indiana 4
Napoli 4
Ottawa 4
Prescot 4
Santeramo in Colle 4
Taranto 4
Acton 3
Brahmapur 3
Brno 3
Caserta 3
Chicago 3
Chongqing 3
Cleveland 3
Falls Church 3
Heze 3
Totale 10.321
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 159
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 137
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 133
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 128
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 122
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 121
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 118
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 114
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 113
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 112
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 108
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 108
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 101
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 100
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 100
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 99
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 99
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 99
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 98
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 98
Structural development studies of PPARs ligands based on tyrosine scaffold. 98
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 96
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 95
The practice of medicinal chemistry 94
Le applicazioni della chimica farmaceutica 93
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 93
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 93
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 93
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 93
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 91
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 90
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 89
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 89
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 89
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 88
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 85
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 85
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 85
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 83
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 83
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 83
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 83
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 83
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 83
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 80
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 80
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 80
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 80
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 79
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 79
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 79
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 78
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 78
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 78
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 77
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 77
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 75
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 75
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 74
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 74
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 73
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 73
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 73
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 72
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 71
2-(9-Antryl)alcanoic acids as chloride channel modulators 70
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 70
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 67
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 66
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 66
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 66
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 66
Mimic catechins to develop selective MMP-2 inhibitors 65
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 64
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 64
In vitro comparison of new bisphosphonic acids and zoledronate effects on human gingival fibroblasts viability, inflammation and matrix turnover 64
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 63
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 63
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 63
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 63
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 62
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 61
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 61
Characterization of a selective CaMKII peptide inhibitor 60
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 60
Kinetic resolution of alpha-substituted alpha-aryloxyacetic acid methyl esters by Candida cylindracea lipasi 59
Synthesis and Antiplatelet Activity of Gemfibrozil Chiral Analogues 59
Microwave-assisted synthesis of KN-62, KN-92 and KN-93 as pharmacological tools for Ca2+/calmodulin-dependent protein kinase II (CAMK II) activity investigation 59
Riduzioni Enantioselettive Biocatalizzate Di Chetoni Prochirali 58
Antiplatelet activity of gemfibrozil chiral analogs. 57
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 57
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 57
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 57
Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2 57
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 57
An Introduction to Medicinal Chemistry 4th ed. 56
null 56
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 55
Totale 8.199
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Categoria #
all - tutte 60.948
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.948
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.100 0 0 0 0 317 199 384 240 388 201 293 78
2020/20212.116 318 94 174 177 167 42 186 100 192 318 201 147
2021/20221.533 63 240 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/2025815 153 90 339 139 94 0 0 0 0 0 0 0
Totale 13.601