IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 9.251
EU - Europa 2.109
AS - Asia 762
OC - Oceania 8
SA - Sud America 6
Continente sconosciuto - Info sul continente non disponibili 4
Totale 12.140
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Nazione #
US - Stati Uniti d'America 9.237
CN - Cina 664
SE - Svezia 564
UA - Ucraina 371
IT - Italia 297
DE - Germania 249
FI - Finlandia 212
FR - Francia 156
GB - Regno Unito 154
IN - India 42
IE - Irlanda 32
BE - Belgio 29
VN - Vietnam 24
CA - Canada 13
CH - Svizzera 10
IR - Iran 9
PT - Portogallo 9
NL - Olanda 7
AU - Australia 5
ID - Indonesia 5
RU - Federazione Russa 5
AT - Austria 3
CL - Cile 3
JP - Giappone 3
KR - Corea 3
NZ - Nuova Zelanda 3
TR - Turchia 3
A1 - Anonimo 2
BR - Brasile 2
EE - Estonia 2
ES - Italia 2
EU - Europa 2
MY - Malesia 2
PL - Polonia 2
TH - Thailandia 2
AR - Argentina 1
BD - Bangladesh 1
BG - Bulgaria 1
DK - Danimarca 1
HK - Hong Kong 1
HR - Croazia 1
IL - Israele 1
IM - Isola di Man 1
KH - Cambogia 1
MT - Malta 1
MX - Messico 1
SG - Singapore 1
Totale 12.140
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Città #
Fairfield 1.164
Chandler 997
Woodbridge 901
Jacksonville 861
Houston 605
Ashburn 604
Cambridge 509
Seattle 456
Nyköping 442
Wilmington 378
Ann Arbor 371
Roxbury 234
Lawrence 231
Nanjing 214
Princeton 149
Des Moines 132
Boardman 125
Beijing 124
New York 110
Bari 101
Inglewood 91
San Diego 61
Nanchang 55
Hebei 46
Dearborn 44
Brooklyn 43
Shenyang 41
Jiaxing 37
Tianjin 34
Changsha 33
Dublin 32
Brussels 29
Marseille 27
London 26
Paris 26
Washington 24
Dong Ket 23
Los Angeles 22
Augusta 19
Pune 17
Boydton 14
Leawood 13
Helsinki 12
Jinan 12
Redwood City 12
San Francisco 12
Zhengzhou 11
Kilburn 10
Toronto 10
Genova 9
Hefei 9
Milan 9
Monmouth Junction 9
Norwalk 9
Haikou 8
Lisbon 8
Edinburgh 7
Lausanne 7
Ningbo 7
Auburn Hills 6
Hounslow 6
Islington 6
Naples 6
San Mateo 6
Ardabil 5
Bitonto 5
Brindisi 5
Guangzhou 5
Patna 5
Salerno 5
Tappahannock 5
Chiswick 4
Frankfurt am Main 4
Indiana 4
Napoli 4
Prescot 4
Santeramo in Colle 4
Taranto 4
Acton 3
Bologna 3
Brahmapur 3
Caserta 3
Chicago 3
Cleveland 3
Falls Church 3
Kunming 3
Mumbai 3
Nürnberg 3
Redmond 3
Stockholm 3
Taizhou 3
Vienna 3
Villa Di Serio 3
Yellow Springs 3
Amsterdam 2
Arzano 2
Bokaro 2
Camden 2
Cassano Magnago 2
Castellana Grotte 2
Totale 9.779
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 156
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 131
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 126
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 126
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 114
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 113
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 113
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 110
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 109
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 109
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 107
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 104
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 98
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 98
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 98
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 96
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 96
Structural development studies of PPARs ligands based on tyrosine scaffold. 95
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 94
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 94
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 93
The practice of medicinal chemistry 92
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 90
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 90
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 89
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 89
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 88
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 88
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 87
Le applicazioni della chimica farmaceutica 87
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 87
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 86
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 85
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 84
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 82
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 82
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 82
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 81
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 81
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 81
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 81
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 80
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 80
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 79
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 77
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 77
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 77
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 76
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 76
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 75
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 75
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 75
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 75
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 72
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 72
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 72
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 71
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 71
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 70
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 70
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 68
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 67
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 66
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 65
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 65
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 65
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 64
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 64
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 64
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 63
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 62
In vitro comparison of new bisphosphonic acids and zoledronate effects on human gingival fibroblasts viability, inflammation and matrix turnover 62
Mimic catechins to develop selective MMP-2 inhibitors 62
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 61
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 61
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 61
2-(9-Antryl)alcanoic acids as chloride channel modulators 60
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 60
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 60
Synthesis and Antiplatelet Activity of Gemfibrozil Chiral Analogues 59
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 59
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 59
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 59
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 58
Characterization of a selective CaMKII peptide inhibitor 58
Kinetic resolution of alpha-substituted alpha-aryloxyacetic acid methyl esters by Candida cylindracea lipasi 57
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 57
Synthesis and evaluation of new tripeptide phosphonate inhibitors of MMP-8 and MMP-2 57
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 56
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 56
null 56
Antiplatelet activity of gemfibrozil chiral analogs. 55
Riduzioni Enantioselettive Biocatalizzate Di Chetoni Prochirali 54
Microwave-assisted synthesis of KN-62, KN-92 and KN-93 as pharmacological tools for Ca2+/calmodulin-dependent protein kinase II (CAMK II) activity investigation 53
Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines 53
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 52
Trans-Dichloro(stilbazol)(methyl n-alkyl sulfoxide)platinum(II) complexes. The first examples of metallomesogens containing chiral centres directly bonded to the metal 51
Introduzione alla chimica farmaceutica 51
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 51
Totale 7.806
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Categoria #
all - tutte 50.233
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 50.233
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019647 0 0 0 0 0 0 0 0 0 0 322 325
2019/20203.248 628 187 97 236 317 199 384 240 388 201 293 78
2020/20212.116 318 94 174 177 167 42 186 100 192 318 201 147
2021/20221.533 63 240 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024759 78 151 50 50 86 224 41 38 14 27 0 0
Totale 12.656