IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 12.456
AS - Asia 5.226
EU - Europa 4.662
SA - Sud America 1.425
AF - Africa 207
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 4
Totale 23.989
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Nazione #
US - Stati Uniti d'America 12.253
SG - Singapore 2.077
IT - Italia 1.542
CN - Cina 1.332
BR - Brasile 1.131
HK - Hong Kong 668
SE - Svezia 579
RU - Federazione Russa 457
FR - Francia 424
DE - Germania 403
UA - Ucraina 389
VN - Vietnam 319
FI - Finlandia 316
GB - Regno Unito 278
IN - India 226
BD - Bangladesh 112
CA - Canada 94
AR - Argentina 91
IQ - Iraq 68
ID - Indonesia 61
MX - Messico 58
EC - Ecuador 54
TR - Turchia 53
CI - Costa d'Avorio 44
CO - Colombia 43
IE - Irlanda 41
ZA - Sudafrica 39
AT - Austria 36
JP - Giappone 36
BE - Belgio 35
PK - Pakistan 31
NL - Olanda 30
VE - Venezuela 30
MY - Malesia 29
PL - Polonia 27
SA - Arabia Saudita 27
CL - Cile 24
ES - Italia 23
MA - Marocco 23
PH - Filippine 23
PY - Paraguay 19
EG - Egitto 18
TN - Tunisia 18
UZ - Uzbekistan 18
KE - Kenya 17
CH - Svizzera 16
PE - Perù 15
JM - Giamaica 14
JO - Giordania 14
LT - Lituania 12
AE - Emirati Arabi Uniti 11
KR - Corea 11
LB - Libano 11
NP - Nepal 10
UY - Uruguay 10
IL - Israele 9
IR - Iran 9
OM - Oman 9
PT - Portogallo 9
AZ - Azerbaigian 8
DZ - Algeria 8
CZ - Repubblica Ceca 7
AL - Albania 6
BG - Bulgaria 6
BH - Bahrain 6
BO - Bolivia 6
DO - Repubblica Dominicana 6
ET - Etiopia 6
PS - Palestinian Territory 6
SN - Senegal 6
AO - Angola 5
AU - Australia 5
KG - Kirghizistan 5
KW - Kuwait 5
KZ - Kazakistan 5
TT - Trinidad e Tobago 5
CR - Costa Rica 4
CY - Cipro 4
GE - Georgia 4
HU - Ungheria 4
NI - Nicaragua 4
SV - El Salvador 4
TH - Thailandia 4
DK - Danimarca 3
MD - Moldavia 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PA - Panama 3
SY - Repubblica araba siriana 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AM - Armenia 2
BB - Barbados 2
DM - Dominica 2
EE - Estonia 2
EU - Europa 2
GA - Gabon 2
GH - Ghana 2
GR - Grecia 2
GT - Guatemala 2
Totale 23.946
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Città #
Fairfield 1.165
Ashburn 1.123
Singapore 1.025
Chandler 997
Woodbridge 903
Jacksonville 864
San Jose 689
Hong Kong 660
Houston 614
Milan 606
Cambridge 510
Seattle 464
Nyköping 442
Wilmington 379
Ann Arbor 371
Beijing 325
Dallas 258
Roxbury 234
Lawrence 231
Nanjing 217
Lauterbourg 216
Rome 194
New York 177
Boardman 155
Princeton 149
Des Moines 133
Los Angeles 131
Bari 120
Ho Chi Minh City 116
Santa Clara 103
Helsinki 100
São Paulo 98
Inglewood 91
Council Bluffs 86
Munich 74
Brooklyn 69
Hanoi 62
San Diego 61
London 59
Figino 55
Nanchang 55
Naples 50
Turin 49
Hebei 46
Abidjan 44
Dearborn 44
Shenyang 43
Buffalo 42
Rio de Janeiro 42
Chicago 41
Jiaxing 41
Dublin 39
Jakarta 38
Moscow 38
Changsha 37
Frankfurt am Main 36
Orem 36
Tianjin 36
Brussels 35
Tokyo 34
San Francisco 31
Montreal 29
Baghdad 28
Marseille 28
North Bergen 28
Paris 28
Atlanta 27
Columbus 27
Washington 27
Chennai 25
Mexico City 25
Johannesburg 24
Dong Ket 23
Florence 23
Shanghai 23
Warsaw 23
Guangzhou 22
Belo Horizonte 20
Boston 20
Curitiba 20
Denver 20
Mumbai 20
Pune 20
Augusta 19
Guayaquil 19
Toronto 19
Fragagnano 18
Poplar 18
Stockholm 18
Tashkent 18
Boydton 17
Kuala Lumpur 17
Nuremberg 17
Quito 17
Wuhan 17
Turku 16
Falkenstein 15
Guarulhos 15
Amsterdam 14
Bologna 14
Totale 16.001
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 235
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 208
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 208
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 192
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 179
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 170
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 167
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 165
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 161
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 160
2-(9-Antryl)alcanoic acids as chloride channel modulators 159
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 158
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 158
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 156
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 156
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 155
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 154
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 154
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 153
Le applicazioni della chimica farmaceutica 152
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 152
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 151
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 151
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 150
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 149
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 149
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 148
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 146
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 145
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 144
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
The practice of medicinal chemistry 143
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 143
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 143
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 140
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 139
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 138
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 135
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 134
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 133
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 133
Structural development studies of PPARs ligands based on tyrosine scaffold. 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 132
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 131
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 131
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 130
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 130
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 129
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 128
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 128
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 128
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 126
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 126
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 126
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 125
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 125
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 124
Titanium Surface Coated With Bisphosphonate Loaded Liposomes: A Preliminary Approach To Implant Osseointegration 123
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 123
An Introduction to Medicinal Chemistry 122
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 122
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 122
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 121
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 121
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 121
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 120
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 119
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 119
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 118
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 118
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 117
Mimic catechins to develop selective MMP-2 inhibitors 117
Candida Cylindracea Lipase-Mediated Kinetic Resolution Of α-Substituted-α-Ariloxyacetic Acid Methyl Esters 116
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 115
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 115
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 115
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 115
Candida Cylindracea lipase-mediated kinetic resolution of a-substituted a-aryloxyacetic acid methyl esters 114
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 114
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 114
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 113
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 113
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 112
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 111
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 110
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 109
Risoluzione Cinetica Catalizzata da Lipasi di Analoghi Rigidi dell’Acido Clofibrico 108
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 108
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 107
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 106
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 106
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 105
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 104
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 103
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 101
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 100
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 100
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 100
Totale 13.411
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Categoria #
all - tutte 103.966
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 103.966
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.533 63 240 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/20253.597 153 90 339 139 103 239 278 343 149 191 447 1.126
2025/20268.062 998 442 548 955 730 399 885 257 678 805 273 1.092
2026/2027145 145 0 0 0 0 0 0 0 0 0 0 0
Totale 24.590