IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 11.976
AS - Asia 5.157
EU - Europa 3.616
SA - Sud America 1.414
AF - Africa 206
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 4
Totale 22.382
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Nazione #
US - Stati Uniti d'America 11.807
SG - Singapore 2.052
CN - Cina 1.319
BR - Brasile 1.126
HK - Hong Kong 656
SE - Svezia 579
IT - Italia 511
RU - Federazione Russa 457
FR - Francia 422
DE - Germania 403
UA - Ucraina 389
VN - Vietnam 319
FI - Finlandia 316
GB - Regno Unito 274
IN - India 221
BD - Bangladesh 101
AR - Argentina 90
CA - Canada 76
IQ - Iraq 68
ID - Indonesia 61
EC - Ecuador 53
TR - Turchia 53
MX - Messico 52
CI - Costa d'Avorio 44
CO - Colombia 40
IE - Irlanda 40
ZA - Sudafrica 39
AT - Austria 36
BE - Belgio 35
JP - Giappone 33
PK - Pakistan 31
NL - Olanda 30
MY - Malesia 29
VE - Venezuela 29
PL - Polonia 27
SA - Arabia Saudita 27
CL - Cile 24
MA - Marocco 23
PH - Filippine 23
ES - Italia 21
PY - Paraguay 19
EG - Egitto 18
TN - Tunisia 18
UZ - Uzbekistan 18
KE - Kenya 17
PE - Perù 15
CH - Svizzera 14
JO - Giordania 14
JM - Giamaica 12
LT - Lituania 12
AE - Emirati Arabi Uniti 11
KR - Corea 11
LB - Libano 11
NP - Nepal 10
UY - Uruguay 10
IL - Israele 9
IR - Iran 9
OM - Oman 9
PT - Portogallo 9
AZ - Azerbaigian 8
DZ - Algeria 8
CZ - Repubblica Ceca 7
BH - Bahrain 6
BO - Bolivia 6
DO - Repubblica Dominicana 6
ET - Etiopia 6
PS - Palestinian Territory 6
SN - Senegal 6
AL - Albania 5
AO - Angola 5
AU - Australia 5
KG - Kirghizistan 5
KW - Kuwait 5
KZ - Kazakistan 5
BG - Bulgaria 4
CY - Cipro 4
GE - Georgia 4
HU - Ungheria 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
DK - Danimarca 3
MD - Moldavia 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PA - Panama 3
SV - El Salvador 3
SY - Repubblica araba siriana 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AM - Armenia 2
BB - Barbados 2
CR - Costa Rica 2
DM - Dominica 2
EE - Estonia 2
EU - Europa 2
GA - Gabon 2
GH - Ghana 2
GR - Grecia 2
GT - Guatemala 2
GY - Guiana 2
Totale 22.343
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Città #
Fairfield 1.164
Ashburn 1.087
Singapore 1.011
Chandler 997
Woodbridge 902
Jacksonville 862
Hong Kong 648
Houston 614
San Jose 570
Cambridge 509
Seattle 463
Nyköping 442
Wilmington 379
Ann Arbor 371
Beijing 322
Dallas 254
Roxbury 234
Lawrence 231
Nanjing 217
Lauterbourg 216
New York 161
Princeton 149
Boardman 148
Des Moines 133
Los Angeles 125
Ho Chi Minh City 116
Bari 115
Helsinki 100
São Paulo 98
Inglewood 91
Council Bluffs 86
Santa Clara 75
Munich 74
Brooklyn 65
Hanoi 62
San Diego 61
London 57
Nanchang 55
Hebei 46
Abidjan 44
Dearborn 44
Shenyang 43
Buffalo 41
Jiaxing 41
Rio de Janeiro 41
Chicago 39
Dublin 39
Jakarta 38
Moscow 38
Changsha 37
Frankfurt am Main 36
Tianjin 36
Brussels 35
Naples 34
Orem 34
San Francisco 31
Tokyo 31
Baghdad 28
Marseille 28
Paris 28
Montreal 27
North Bergen 27
Atlanta 25
Chennai 25
Johannesburg 24
Washington 24
Dong Ket 23
Warsaw 23
Guangzhou 22
Milan 22
Shanghai 22
Belo Horizonte 20
Curitiba 20
Mumbai 20
Pune 20
Augusta 19
Boston 19
Denver 19
Guayaquil 19
Mexico City 19
Fragagnano 18
Poplar 18
Stockholm 18
Tashkent 18
Toronto 18
Kuala Lumpur 17
Nuremberg 17
Wuhan 17
Quito 16
Rome 16
Turku 16
Boydton 15
Falkenstein 15
Guarulhos 15
Amsterdam 14
Da Nang 14
Dhaka 14
Florence 14
Manchester 14
Nairobi 14
Totale 14.833
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 223
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 204
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 203
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 181
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 180
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 178
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 164
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 157
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 153
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 152
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 152
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 151
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 151
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 149
2-(9-Antryl)alcanoic acids as chloride channel modulators 149
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 149
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 147
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 146
Le applicazioni della chimica farmaceutica 145
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 144
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 144
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 143
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 142
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 141
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 140
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 140
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 140
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 139
The practice of medicinal chemistry 137
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 137
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 137
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 137
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 136
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 136
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 135
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 133
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 133
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 130
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 130
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 130
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 128
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 125
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 125
Structural development studies of PPARs ligands based on tyrosine scaffold. 122
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 122
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 122
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 121
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 120
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 120
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 120
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 119
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 119
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 119
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 119
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 118
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 118
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 118
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 118
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 118
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 118
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 117
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 117
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 115
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 115
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 115
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 114
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 114
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 113
Titanium Surface Coated With Bisphosphonate Loaded Liposomes: A Preliminary Approach To Implant Osseointegration 112
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 111
An Introduction to Medicinal Chemistry 111
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 110
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 110
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 110
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 110
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 109
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 108
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 108
Mimic catechins to develop selective MMP-2 inhibitors 108
Risoluzione Cinetica Catalizzata da Lipasi di Analoghi Rigidi dell’Acido Clofibrico 107
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 107
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 107
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 107
Candida Cylindracea Lipase-Mediated Kinetic Resolution Of α-Substituted-α-Ariloxyacetic Acid Methyl Esters 106
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 106
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 105
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 104
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 103
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 102
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 102
Candida Cylindracea lipase-mediated kinetic resolution of a-substituted a-aryloxyacetic acid methyl esters 102
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 101
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 100
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 98
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 98
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 98
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 96
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 94
Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative 93
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 93
Totale 12.683
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Categoria #
all - tutte 95.887
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 95.887
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021666 0 0 0 0 0 0 0 0 0 318 201 147
2021/20221.533 63 240 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/20253.597 153 90 339 139 103 239 278 343 149 191 447 1.126
2025/20266.596 998 442 548 955 730 399 885 257 678 704 0 0
Totale 22.979