IRIS
TORTORELLA, Paolo
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.569
EU - Europa 2.769
AS - Asia 1.603
SA - Sud America 305
AF - Africa 10
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 4
Totale 14.268
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 9.538
CN - Cina 880
SE - Svezia 564
SG - Singapore 524
RU - Federazione Russa 434
UA - Ucraina 373
IT - Italia 370
DE - Germania 309
BR - Brasile 275
FI - Finlandia 227
GB - Regno Unito 175
FR - Francia 174
IN - India 57
ID - Indonesia 37
BE - Belgio 33
IE - Irlanda 32
CA - Canada 25
VN - Vietnam 24
AT - Austria 18
NL - Olanda 17
HK - Hong Kong 16
CH - Svizzera 12
TR - Turchia 11
IR - Iran 9
PT - Portogallo 9
AR - Argentina 8
CL - Cile 6
KR - Corea 6
AU - Australia 5
BD - Bangladesh 5
LT - Lituania 5
VE - Venezuela 5
EC - Ecuador 4
IL - Israele 4
IQ - Iraq 4
MX - Messico 4
CZ - Repubblica Ceca 3
EG - Egitto 3
JP - Giappone 3
NZ - Nuova Zelanda 3
PE - Perù 3
A1 - Anonimo 2
CO - Colombia 2
EE - Estonia 2
ES - Italia 2
EU - Europa 2
JO - Giordania 2
MA - Marocco 2
MY - Malesia 2
NP - Nepal 2
PK - Pakistan 2
PL - Polonia 2
RS - Serbia 2
TH - Thailandia 2
ZA - Sudafrica 2
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BG - Bulgaria 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BO - Bolivia 1
DK - Danimarca 1
DZ - Algeria 1
GE - Georgia 1
GT - Guatemala 1
HR - Croazia 1
IM - Isola di Man 1
JM - Giamaica 1
KE - Kenya 1
KG - Kirghizistan 1
KH - Cambogia 1
MK - Macedonia 1
MT - Malta 1
OM - Oman 1
PS - Palestinian Territory 1
PY - Paraguay 1
SN - Senegal 1
SY - Repubblica araba siriana 1
TJ - Tagikistan 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 14.268
Salva come PNG Salva come JPEG
Città #
Fairfield 1.164
Chandler 997
Woodbridge 901
Jacksonville 861
Ashburn 651
Houston 605
Cambridge 509
Seattle 457
Nyköping 442
Wilmington 378
Ann Arbor 371
Singapore 281
Roxbury 234
Lawrence 231
Nanjing 217
Princeton 149
Boardman 148
Beijing 139
Des Moines 132
Bari 112
New York 110
Inglewood 91
San Diego 61
Nanchang 55
Hebei 46
Dearborn 44
Brooklyn 43
Shenyang 43
Santa Clara 42
Jiaxing 41
Los Angeles 37
Moscow 37
London 36
Changsha 34
Tianjin 34
Brussels 33
Dublin 32
Jakarta 32
Helsinki 27
Marseille 27
North Bergen 27
Paris 26
Munich 25
Washington 24
Dong Ket 23
São Paulo 22
Shanghai 20
Augusta 19
Guangzhou 19
Pune 19
Naples 17
Wuhan 17
Council Bluffs 16
Milan 16
Boydton 14
Hong Kong 14
Toronto 14
Frankfurt am Main 13
Jinan 13
Leawood 13
San Francisco 13
Redwood City 12
Zhengzhou 11
Kilburn 10
Nuremberg 10
Vienna 10
Wuxi 10
Genova 9
Hefei 9
Monmouth Junction 9
Norwalk 9
Belo Horizonte 8
Haikou 8
Lisbon 8
Shenzhen 8
Düsseldorf 7
Edinburgh 7
Falkenstein 7
Lausanne 7
Ningbo 7
Ottawa 7
Patna 7
Salerno 7
Auburn Hills 6
Bitonto 6
Hounslow 6
Islington 6
Kolkata 6
Rio de Janeiro 6
San Mateo 6
Taizhou 6
Ardabil 5
Brindisi 5
Curitiba 5
Formello 5
Jinhua 5
Lauterbourg 5
Quanzhou 5
Tappahannock 5
Bologna 4
Totale 10.547
Salva come PNG Salva come JPEG
Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 177
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 145
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 144
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 133
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 132
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 125
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 122
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 122
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 117
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 116
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 115
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 114
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 108
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 107
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 106
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 106
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 106
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 106
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 104
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 103
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 103
The practice of medicinal chemistry 102
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 102
Structural development studies of PPARs ligands based on tyrosine scaffold. 102
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 102
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 100
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 99
Le applicazioni della chimica farmaceutica 97
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 97
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 97
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 96
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 96
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 95
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 95
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 94
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 93
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 93
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 92
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 92
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 90
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 90
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 89
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 88
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 87
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 87
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 87
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 86
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 85
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 85
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 85
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 85
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 84
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 84
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 83
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 82
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 82
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 82
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 81
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 81
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 81
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 81
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 80
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 80
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 80
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 79
2-(9-Antryl)alcanoic acids as chloride channel modulators 78
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 77
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 77
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 77
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 74
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 74
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 73
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 72
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 70
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 70
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 69
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 69
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 67
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 67
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 67
Mimic catechins to develop selective MMP-2 inhibitors 67
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 66
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 66
Synthesis and Antiplatelet Activity of Gemfibrozil Chiral Analogues 65
In vitro comparison of new bisphosphonic acids and zoledronate effects on human gingival fibroblasts viability, inflammation and matrix turnover 65
Kinetic resolution of alpha-substituted alpha-aryloxyacetic acid methyl esters by Candida cylindracea lipasi 64
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 64
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 64
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 64
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 64
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 63
Risoluzione Cinetica Catalizzata da Lipasi di Analoghi Rigidi dell’Acido Clofibrico 62
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 62
Candida Cylindracea Lipase-Mediated Kinetic Resolution Of α-Substituted-α-Ariloxyacetic Acid Methyl Esters 62
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 62
Characterization of a selective CaMKII peptide inhibitor 62
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 62
Riduzioni Enantioselettive Biocatalizzate Di Chetoni Prochirali 61
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 61
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 61
Totale 8.787
Salva come PNG Salva come JPEG
Categoria #
all - tutte 69.670
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 69.670
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020371 0 0 0 0 0 0 0 0 0 0 293 78
2020/20212.116 318 94 174 177 167 42 186 100 192 318 201 147
2021/20221.533 63 240 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/20252.071 153 90 339 139 103 239 278 343 149 191 47 0
Totale 14.857