IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 13.272
AS - Asia 5.271
EU - Europa 4.689
SA - Sud America 1.447
Continente sconosciuto - Info sul continente non disponibili 608
AF - Africa 208
OC - Oceania 9
Totale 25.504
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Nazione #
US - Stati Uniti d'America 13.050
SG - Singapore 2.082
IT - Italia 1.562
CN - Cina 1.340
BR - Brasile 1.135
HK - Hong Kong 674
SE - Svezia 579
RU - Federazione Russa 457
FR - Francia 425
DE - Germania 404
UA - Ucraina 389
VN - Vietnam 321
FI - Finlandia 316
GB - Regno Unito 281
IN - India 229
BD - Bangladesh 122
CA - Canada 102
AR - Argentina 94
IQ - Iraq 68
ID - Indonesia 64
EC - Ecuador 63
MX - Messico 59
TR - Turchia 54
CO - Colombia 47
CI - Costa d'Avorio 44
IE - Irlanda 41
ZA - Sudafrica 39
AT - Austria 36
JP - Giappone 36
BE - Belgio 35
NL - Olanda 31
PK - Pakistan 31
VE - Venezuela 31
MY - Malesia 29
PH - Filippine 27
PL - Polonia 27
SA - Arabia Saudita 27
CL - Cile 24
ES - Italia 23
MA - Marocco 23
PY - Paraguay 19
EG - Egitto 18
TN - Tunisia 18
UZ - Uzbekistan 18
JM - Giamaica 17
KE - Kenya 17
CH - Svizzera 16
PE - Perù 15
JO - Giordania 14
LT - Lituania 12
AE - Emirati Arabi Uniti 11
KR - Corea 11
LB - Libano 11
NP - Nepal 11
UY - Uruguay 10
IL - Israele 9
IR - Iran 9
OM - Oman 9
PT - Portogallo 9
AZ - Azerbaigian 8
DZ - Algeria 8
BO - Bolivia 7
CR - Costa Rica 7
CZ - Repubblica Ceca 7
TT - Trinidad e Tobago 7
AL - Albania 6
BG - Bulgaria 6
BH - Bahrain 6
DO - Repubblica Dominicana 6
ET - Etiopia 6
PS - Palestinian Territory 6
SN - Senegal 6
TH - Thailandia 6
AO - Angola 5
AU - Australia 5
KG - Kirghizistan 5
KW - Kuwait 5
KZ - Kazakistan 5
SV - El Salvador 5
CY - Cipro 4
GE - Georgia 4
HU - Ungheria 4
NI - Nicaragua 4
BB - Barbados 3
DK - Danimarca 3
HR - Croazia 3
MD - Moldavia 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PA - Panama 3
SY - Repubblica araba siriana 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AM - Armenia 2
DM - Dominica 2
EE - Estonia 2
EU - Europa 2
GA - Gabon 2
GH - Ghana 2
GR - Grecia 2
Totale 24.856
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Città #
Fairfield 1.165
Ashburn 1.146
Singapore 1.029
Chandler 997
Woodbridge 903
San Jose 895
Jacksonville 865
Hong Kong 663
Houston 615
Milan 606
Cambridge 510
Seattle 465
Nyköping 442
Wilmington 379
Ann Arbor 371
Council Bluffs 339
Beijing 330
Dallas 272
Roxbury 234
Lawrence 231
Nanjing 217
Lauterbourg 216
Rome 195
New York 183
Boardman 155
Princeton 149
Los Angeles 136
Des Moines 133
Santa Clara 127
Bari 120
Ho Chi Minh City 116
Helsinki 100
São Paulo 98
Inglewood 91
Munich 74
Brooklyn 73
Hanoi 63
San Diego 62
London 59
Figino 55
Nanchang 55
Chicago 54
Naples 51
Turin 50
Columbus 48
Buffalo 47
Hebei 46
Dearborn 45
Abidjan 44
Shenyang 43
Rio de Janeiro 42
Jiaxing 41
Dublin 39
Jakarta 38
Moscow 38
Changsha 37
Frankfurt am Main 37
Orem 36
Tianjin 36
Brussels 35
Tokyo 34
San Francisco 33
Montreal 30
Washington 29
Atlanta 28
Baghdad 28
Marseille 28
North Bergen 28
Paris 28
Chennai 25
Mexico City 25
Florence 24
Johannesburg 24
Warsaw 24
Dong Ket 23
Guayaquil 23
Shanghai 23
Guangzhou 22
Phoenix 22
Belo Horizonte 20
Boston 20
Curitiba 20
Denver 20
Mumbai 20
Pune 20
Toronto 20
Augusta 19
Fragagnano 18
Poplar 18
Quito 18
Stockholm 18
Tashkent 18
Boydton 17
Kuala Lumpur 17
Nuremberg 17
Wuhan 17
Turku 16
Bologna 15
Falkenstein 15
Guarulhos 15
Totale 16.620
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 239
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 211
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 211
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 194
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 192
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 182
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 175
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 169
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 169
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 168
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 166
2-(9-Antryl)alcanoic acids as chloride channel modulators 164
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 163
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 161
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 161
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 161
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 161
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 159
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 158
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 155
Le applicazioni della chimica farmaceutica 155
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 154
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 153
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 153
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 153
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 151
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 151
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 150
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 150
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 149
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 148
The practice of medicinal chemistry 146
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 145
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 145
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 144
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 142
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 141
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 140
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 139
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 139
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 138
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 137
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 135
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 135
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 134
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 133
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 133
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 133
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 132
Structural development studies of PPARs ligands based on tyrosine scaffold. 132
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 132
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 131
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 130
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 129
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 129
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 128
Titanium Surface Coated With Bisphosphonate Loaded Liposomes: A Preliminary Approach To Implant Osseointegration 128
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 128
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 127
An Introduction to Medicinal Chemistry 126
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 126
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 125
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 124
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 124
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 123
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 122
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 122
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 121
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 120
Candida Cylindracea Lipase-Mediated Kinetic Resolution Of α-Substituted-α-Ariloxyacetic Acid Methyl Esters 120
Candida Cylindracea lipase-mediated kinetic resolution of a-substituted a-aryloxyacetic acid methyl esters 120
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 120
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 120
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 120
Mimic catechins to develop selective MMP-2 inhibitors 119
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 118
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 118
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 118
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 116
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 116
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 116
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 116
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 115
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 115
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 113
Risoluzione Cinetica Catalizzata da Lipasi di Analoghi Rigidi dell’Acido Clofibrico 113
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 113
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 112
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 112
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 111
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 109
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 107
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 107
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 107
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 106
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 106
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 105
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 105
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease 104
Totale 13.725
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Categoria #
all - tutte 107.955
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 107.955
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.230 0 0 24 46 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/20253.597 153 90 339 139 103 239 278 343 149 191 447 1.126
2025/20268.062 998 442 548 955 730 399 885 257 678 805 273 1.092
2026/20271.059 204 420 435 0 0 0 0 0 0 0 0 0
Totale 25.504