IRIS
TORTORELLA, Paolo
 Distribuzione geografica
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Continente #
NA - Nord America 14.673
AS - Asia 5.285
EU - Europa 4.831
SA - Sud America 1.478
Continente sconosciuto - Info sul continente non disponibili 624
AF - Africa 215
OC - Oceania 9
Totale 27.115
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Nazione #
US - Stati Uniti d'America 14.275
SG - Singapore 2.082
IT - Italia 1.676
CN - Cina 1.343
BR - Brasile 1.165
HK - Hong Kong 674
SE - Svezia 579
RU - Federazione Russa 469
FR - Francia 425
DE - Germania 409
UA - Ucraina 390
VN - Vietnam 321
FI - Finlandia 316
GB - Regno Unito 287
IN - India 229
CA - Canada 181
BD - Bangladesh 122
AR - Argentina 94
IQ - Iraq 68
EC - Ecuador 64
ID - Indonesia 64
MX - Messico 59
TR - Turchia 54
CO - Colombia 47
CI - Costa d'Avorio 44
IE - Irlanda 41
ZA - Sudafrica 39
AT - Austria 36
JP - Giappone 36
BE - Belgio 35
NL - Olanda 31
PK - Pakistan 31
VE - Venezuela 31
MY - Malesia 29
PH - Filippine 27
PL - Polonia 27
SA - Arabia Saudita 27
NI - Nicaragua 26
CL - Cile 24
ES - Italia 24
MA - Marocco 23
CR - Costa Rica 21
JM - Giamaica 21
IL - Israele 20
PY - Paraguay 19
EG - Egitto 18
TN - Tunisia 18
UZ - Uzbekistan 18
KE - Kenya 17
SV - El Salvador 17
CH - Svizzera 16
TT - Trinidad e Tobago 16
LT - Lituania 15
PE - Perù 15
JO - Giordania 14
CW - ???statistics.table.value.countryCode.CW??? 13
GT - Guatemala 12
AE - Emirati Arabi Uniti 11
KR - Corea 11
LB - Libano 11
NP - Nepal 11
PR - Porto Rico 11
UY - Uruguay 10
GP - Guadalupe 9
IR - Iran 9
OM - Oman 9
PT - Portogallo 9
AZ - Azerbaigian 8
DZ - Algeria 8
HN - Honduras 8
SC - Seychelles 8
BO - Bolivia 7
CZ - Repubblica Ceca 7
AL - Albania 6
BG - Bulgaria 6
BH - Bahrain 6
DO - Repubblica Dominicana 6
ET - Etiopia 6
PS - Palestinian Territory 6
SN - Senegal 6
TH - Thailandia 6
AO - Angola 5
AU - Australia 5
KG - Kirghizistan 5
KW - Kuwait 5
KZ - Kazakistan 5
CY - Cipro 4
GE - Georgia 4
HU - Ungheria 4
BB - Barbados 3
DK - Danimarca 3
HR - Croazia 3
MD - Moldavia 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PA - Panama 3
SY - Repubblica araba siriana 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AM - Armenia 2
Totale 26.457
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Città #
Ashburn 1.583
Fairfield 1.165
San Jose 1.043
Singapore 1.029
Chandler 997
Woodbridge 903
Jacksonville 865
Hong Kong 663
Milan 621
Houston 616
Cambridge 511
Seattle 466
Nyköping 442
Wilmington 380
Ann Arbor 371
Council Bluffs 364
Beijing 330
Dallas 276
Roxbury 234
Lawrence 231
Nanjing 217
Lauterbourg 216
Rome 211
New York 196
Boardman 157
Los Angeles 151
Princeton 150
Santa Clara 143
Des Moines 134
São Paulo 122
Bari 121
Ho Chi Minh City 116
Washington 114
Helsinki 100
Inglewood 91
Brooklyn 77
Munich 74
Hanoi 63
London 62
San Diego 62
Figino 58
Chicago 56
Nanchang 55
Naples 54
Turin 51
Columbus 49
Buffalo 47
Hebei 46
Dearborn 45
Abidjan 44
Shenyang 43
Rio de Janeiro 42
Jiaxing 41
North Bergen 40
Dublin 39
Frankfurt am Main 38
Jakarta 38
Moscow 38
Changsha 37
Montreal 37
Orem 36
Tianjin 36
Brussels 35
San Francisco 34
Tokyo 34
Toronto 34
Atlanta 33
Baghdad 28
Marseille 28
Paris 28
Managua 26
Chennai 25
Florence 25
Mexico City 25
Phoenix 25
Johannesburg 24
Warsaw 24
Dong Ket 23
Guayaquil 23
Shanghai 23
Denver 22
Guangzhou 22
Belo Horizonte 20
Bologna 20
Boston 20
Curitiba 20
Mumbai 20
Pune 20
Augusta 19
Quito 19
Fragagnano 18
Poplar 18
Stockholm 18
Tashkent 18
Boydton 17
Brasília 17
Kuala Lumpur 17
Nuremberg 17
Wuhan 17
Kingston 16
Totale 17.509
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 246
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 220
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 219
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 209
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 201
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 189
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 186
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 186
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 182
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 175
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 172
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 171
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 170
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors 169
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 169
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 168
2-(9-Antryl)alcanoic acids as chloride channel modulators 167
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 166
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 164
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 164
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 163
Titanium Surface Coated With Bisphosphonate Loaded Liposomes: A Preliminary Approach To Implant Osseointegration 162
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 159
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 159
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 159
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 158
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 158
Stereospecific cross-coupling reactions of 3-arylsulfinylpropenoates with organometallic reagents 157
Le applicazioni della chimica farmaceutica 157
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 156
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists 155
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 154
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 152
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 151
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 150
The practice of medicinal chemistry 149
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 149
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 149
Amino Acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors 148
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors 148
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 147
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 146
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 145
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 144
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 144
AMBER force field implementation of the boronate function to simulate the inhibition of B-lactamases by alkyl and aryl boronic acids 142
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs 141
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 141
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 139
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 139
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 139
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 139
Structural development studies of PPARs ligands based on tyrosine scaffold. 136
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 136
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 136
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 136
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 134
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 134
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 133
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 133
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 132
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 132
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 131
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 130
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 130
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 130
Risoluzione Cinetica Catalizzata da Lipasi di Analoghi Rigidi dell’Acido Clofibrico 129
An Introduction to Medicinal Chemistry 129
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 129
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 128
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 128
A novel route to enantiomerically pure sufoxides through displacement of a carbon leaving group 127
Candida Cylindracea lipase-mediated kinetic resolution of a-substituted a-aryloxyacetic acid methyl esters 127
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 126
Mimic catechins to develop selective MMP-2 inhibitors 126
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 125
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process 125
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 124
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 124
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 124
Candida Cylindracea Lipase-Mediated Kinetic Resolution Of α-Substituted-α-Ariloxyacetic Acid Methyl Esters 124
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 123
Structural Insight into the Stereoselective Inhibition of MMP-8 by Enantiomeric Sulfonamide Phosphonates 122
Substituted Benzene Anions as Leaving Groups in the Reaction of Sulfinyl Derivatives with Grignard Reagents: A New and Convenient Route to Dialkyl Sulfoxides in High Enantiomeric Purity 121
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 121
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 120
An Introduction to Medicinal Chemistry 4th ed. 120
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 120
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 120
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 119
Microwave-assisted synthesis of KN-62, KN-92 and KN-93 as pharmacological tools for Ca2+/calmodulin-dependent protein kinase II (CAMK II) activity investigation 118
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 117
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 117
Use of readily available chiral compounds related to the Betti base in the enantioselective addition of diethylzinc to aryl aldehydes 115
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 115
An update of multiple choice questions (MCQs): the sequential multiple choice questions (SMCQs) 113
Selective MMP inhibitors for the treatment of skeletal malignancy. 113
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 112
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 112
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 112
Totale 14.480
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Categoria #
all - tutte 113.399
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 113.399
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.160 0 0 0 0 59 69 65 63 92 70 267 475
2022/20232.636 452 203 163 243 349 360 28 274 441 19 65 39
2023/2024889 78 151 50 50 86 224 41 38 14 27 34 96
2024/20253.597 153 90 339 139 103 239 278 343 149 191 447 1.126
2025/20268.062 998 442 548 955 730 399 885 257 678 805 273 1.092
2026/20272.670 204 420 869 1.141 36 0 0 0 0 0 0 0
Totale 27.115