| Nome |
# |
|
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II, file dd9e0c67-c9bf-1e9c-e053-3a05fe0a45ef
|
161
|
|
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease, file dd9e0c67-3027-1e9c-e053-3a05fe0a45ef
|
145
|
|
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment, file dd9e0c64-814b-1e9c-e053-3a05fe0a45ef
|
77
|
|
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis, file dd9e0c64-85f8-1e9c-e053-3a05fe0a45ef
|
77
|
|
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity, file dd9e0c66-8f8e-1e9c-e053-3a05fe0a45ef
|
77
|
|
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents, file dd9e0c68-5c34-1e9c-e053-3a05fe0a45ef
|
70
|
|
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode, file dd9e0c63-bb13-1e9c-e053-3a05fe0a45ef
|
69
|
|
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth, file dd9e0c68-a0fb-1e9c-e053-3a05fe0a45ef
|
63
|
|
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study, file dd9e0c66-8dca-1e9c-e053-3a05fe0a45ef
|
61
|
|
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy, file dd9e0c68-4fa9-1e9c-e053-3a05fe0a45ef
|
61
|
|
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin, file dd9e0c63-e8eb-1e9c-e053-3a05fe0a45ef
|
55
|
|
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies, file dd9e0c63-b75f-1e9c-e053-3a05fe0a45ef
|
51
|
|
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation, file dd9e0c6c-871b-1e9c-e053-3a05fe0a45ef
|
49
|
|
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity, file dd9e0c6c-8293-1e9c-e053-3a05fe0a45ef
|
43
|
|
Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrides by chiral N-(biarylsulfonyl)-phosphonic acids., file dd9e0c66-6835-1e9c-e053-3a05fe0a45ef
|
32
|
|
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles, file dd9e0c6c-8d86-1e9c-e053-3a05fe0a45ef
|
29
|
|
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome., file 06729c17-d60a-4dee-a0be-40abecb054f4
|
16
|
|
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels, file dd9e0c66-4f31-1e9c-e053-3a05fe0a45ef
|
10
|
|
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs., file dd9e0c64-b03e-1e9c-e053-3a05fe0a45ef
|
7
|
|
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines, file dd9e0c66-8bee-1e9c-e053-3a05fe0a45ef
|
7
|
|
Erratum: Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels, file dd9e0c62-871f-1e9c-e053-3a05fe0a45ef
|
6
|
|
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme, file dd9e0c63-b145-1e9c-e053-3a05fe0a45ef
|
6
|
|
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome., file dd9e0c66-8db4-1e9c-e053-3a05fe0a45ef
|
6
|
|
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis, file dd9e0c65-6c59-1e9c-e053-3a05fe0a45ef
|
5
|
|
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders, file dd9e0c68-60ff-1e9c-e053-3a05fe0a45ef
|
5
|
|
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo, file dd9e0c65-f6d6-1e9c-e053-3a05fe0a45ef
|
4
|
|
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation, file dd9e0c66-8dcd-1e9c-e053-3a05fe0a45ef
|
4
|
|
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors, file dd9e0c68-b3f1-1e9c-e053-3a05fe0a45ef
|
4
|
|
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors, file dd9e0c63-b322-1e9c-e053-3a05fe0a45ef
|
3
|
|
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands, file dd9e0c66-8db0-1e9c-e053-3a05fe0a45ef
|
3
|
|
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity, file dd9e0c66-8f88-1e9c-e053-3a05fe0a45ef
|
3
|
|
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175, file dd9e0c66-c39d-1e9c-e053-3a05fe0a45ef
|
3
|
|
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels, file dd9e0c67-d164-1e9c-e053-3a05fe0a45ef
|
3
|
|
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors, file dd9e0c68-6100-1e9c-e053-3a05fe0a45ef
|
3
|
|
Natural compounds as FAAH inhibitors: preliminary screening and potential developments, file dd9e0c68-766e-1e9c-e053-3a05fe0a45ef
|
3
|
|
Selective MMP inhibitors for the treatment of skeletal malignancy., file dd9e0c68-96da-1e9c-e053-3a05fe0a45ef
|
3
|
|
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation, file dd9e0c6c-7624-1e9c-e053-3a05fe0a45ef
|
3
|
|
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases, file 4ddc2f30-afcc-4be7-9a1f-eefb002ce944
|
2
|
|
New rivastigmine-like compounds for the potential treatment of Alzheimer’s disease: a multi-target approach, file 5e6a9492-6c70-4709-81bc-1ed2ff532a07
|
2
|
|
Peptidyl 3-Substituted 1-Hydroxyureas as Isosteric Analogues of Succinylhydroxamate MMP Inhibitors, file dd9e0c62-4c70-1e9c-e053-3a05fe0a45ef
|
2
|
|
Characterization of a selective CaMKII peptide inhibitor, file dd9e0c62-801f-1e9c-e053-3a05fe0a45ef
|
2
|
|
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1, file dd9e0c63-a198-1e9c-e053-3a05fe0a45ef
|
2
|
|
In vitro comparison of new bisphosphonic acids and zoledronate effects on human gingival fibroblasts viability, inflammation and matrix turnover, file dd9e0c63-b666-1e9c-e053-3a05fe0a45ef
|
2
|
|
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles, file dd9e0c66-6838-1e9c-e053-3a05fe0a45ef
|
2
|
|
Mimic catechins to develop selective MMP-2 inhibitors, file dd9e0c66-8dc8-1e9c-e053-3a05fe0a45ef
|
2
|
|
Structural development studies of PPARs ligands based on tyrosine scaffold., file dd9e0c66-c39f-1e9c-e053-3a05fe0a45ef
|
2
|
|
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease, file dd9e0c68-504e-1e9c-e053-3a05fe0a45ef
|
2
|
|
Novel small molecules for PPARs modulation and their potential use for treatment of metabolic disorders, file dd9e0c68-766a-1e9c-e053-3a05fe0a45ef
|
2
|
|
Synthesis and biological activity evaluation of novel diphenylmethane-based ligands for PPARα and PPARγ, file dd9e0c68-772a-1e9c-e053-3a05fe0a45ef
|
2
|
|
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13, file dd9e0c68-a322-1e9c-e053-3a05fe0a45ef
|
2
|
|
Multi-Target Approach for the Design of New Compounds Potentially Useful for the Prevention and Treatment of Cardiovascular and/or Neurodegenerative Diseases, file dd9e0c6b-7123-1e9c-e053-3a05fe0a45ef
|
2
|
|
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases, file dd9e0c6b-744c-1e9c-e053-3a05fe0a45ef
|
2
|
|
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease, file dd9e0c6c-30c6-1e9c-e053-3a05fe0a45ef
|
2
|
|
Rivastigmine-based hybrids: a multi-target approach to anti-Alzheimer’s drug design, file 0202e201-85c2-4cc9-b4fc-987e2dd8682d
|
1
|
|
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease, file 0d9474da-8d60-447e-aa67-026b5e9ea1bd
|
1
|
|
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists, file dd9e0c62-7432-1e9c-e053-3a05fe0a45ef
|
1
|
|
Introduzione alla chimica farmaceutica, file dd9e0c62-806c-1e9c-e053-3a05fe0a45ef
|
1
|
|
N-hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8, file dd9e0c62-894a-1e9c-e053-3a05fe0a45ef
|
1
|
|
a-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs, file dd9e0c62-8962-1e9c-e053-3a05fe0a45ef
|
1
|
|
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity, file dd9e0c63-3345-1e9c-e053-3a05fe0a45ef
|
1
|
|
Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process, file dd9e0c63-bf2b-1e9c-e053-3a05fe0a45ef
|
1
|
|
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer, file dd9e0c68-a2af-1e9c-e053-3a05fe0a45ef
|
1
|
|
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors, file dd9e0c68-a2b1-1e9c-e053-3a05fe0a45ef
|
1
|
|
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth, file dd9e0c68-a4eb-1e9c-e053-3a05fe0a45ef
|
1
|
|
Tackling bone metastatic breast cancer growth with novel bone-seeking matrix metalloproteinase-2 inhibitors, file dd9e0c68-a4ee-1e9c-e053-3a05fe0a45ef
|
1
|
|
Synthesis of N-acylsulfonilamides and amides as potential PPARalpha antagonists, file dd9e0c68-aec3-1e9c-e053-3a05fe0a45ef
|
1
|
|
Phosphonate Emerging Zinc Binding Group in Matrix Metalloproteinase Inhibitors, file dd9e0c68-d914-1e9c-e053-3a05fe0a45ef
|
1
|
|
Multiple causes, multiple targets: FAAH as a centerpiece for therapy of multifactorial pathologies., file dd9e0c6b-7519-1e9c-e053-3a05fe0a45ef
|
1
|
|
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE), file dd9e0c6c-06fc-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
1.275 |