IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 10.874
EU - Europa 4.584
AS - Asia 4.455
SA - Sud America 1.066
AF - Africa 139
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 7
Totale 21.135
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Nazione #
US - Stati Uniti d'America 10.652
SG - Singapore 1.717
CN - Cina 1.269
DE - Germania 1.052
SE - Svezia 934
BR - Brasile 921
RU - Federazione Russa 623
IT - Italia 602
HK - Hong Kong 556
VN - Vietnam 552
GB - Regno Unito 441
UA - Ucraina 317
FI - Finlandia 256
CA - Canada 153
IN - India 91
FR - Francia 79
CI - Costa d'Avorio 62
AR - Argentina 56
IE - Irlanda 45
MX - Messico 43
BD - Bangladesh 39
BE - Belgio 38
AT - Austria 37
NL - Olanda 37
PL - Polonia 37
JP - Giappone 29
EC - Ecuador 26
ID - Indonesia 25
TR - Turchia 25
ZA - Sudafrica 24
IR - Iran 23
IQ - Iraq 20
CO - Colombia 18
CZ - Repubblica Ceca 18
ES - Italia 18
UZ - Uzbekistan 17
PK - Pakistan 15
VE - Venezuela 13
PY - Paraguay 11
KE - Kenya 10
EG - Egitto 9
RO - Romania 9
AU - Australia 8
CL - Cile 8
IL - Israele 8
JO - Giordania 7
LT - Lituania 7
MA - Marocco 7
AZ - Azerbaigian 6
DZ - Algeria 6
EE - Estonia 6
EU - Europa 6
KZ - Kazakistan 6
NG - Nigeria 6
NP - Nepal 6
PE - Perù 6
SA - Arabia Saudita 6
TN - Tunisia 6
BB - Barbados 4
CH - Svizzera 4
CR - Costa Rica 4
GE - Georgia 4
JM - Giamaica 4
KR - Corea 4
MY - Malesia 4
OM - Oman 4
AE - Emirati Arabi Uniti 3
BG - Bulgaria 3
BH - Bahrain 3
BO - Bolivia 3
DK - Danimarca 3
ET - Etiopia 3
GT - Guatemala 3
KG - Kirghizistan 3
RS - Serbia 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AL - Albania 2
GD - Grenada 2
GR - Grecia 2
HN - Honduras 2
LB - Libano 2
LV - Lettonia 2
MD - Moldavia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
SN - Senegal 2
TH - Thailandia 2
TW - Taiwan 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BY - Bielorussia 1
CY - Cipro 1
DM - Dominica 1
GP - Guadalupe 1
GY - Guiana 1
HR - Croazia 1
KW - Kuwait 1
LY - Libia 1
MK - Macedonia 1
Totale 21.124
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Città #
Fairfield 1.188
Chandler 920
Ashburn 860
Singapore 836
Woodbridge 812
Jacksonville 732
Nyköping 571
Houston 563
Hong Kong 548
Seattle 454
Wilmington 449
Ann Arbor 429
Beijing 396
Bari 393
Cambridge 390
Dallas 373
Dong Ket 332
Nanjing 217
Roxbury 213
Lawrence 207
New York 164
Boardman 161
Princeton 148
Brooklyn 136
Munich 133
Des Moines 122
Los Angeles 112
Montréal 88
Ho Chi Minh City 81
São Paulo 76
Mcallen 68
Inglewood 64
Abidjan 62
Shenyang 62
San Diego 61
Nanchang 58
Hebei 55
London 54
Buffalo 52
Hanoi 51
Jiaxing 50
Santa Clara 49
Dublin 46
Dearborn 43
Brussels 35
Tianjin 34
Turku 34
North Bergen 32
Warsaw 31
Changsha 28
Paris 27
Helsinki 26
Chicago 25
Moscow 24
Tokyo 24
Denver 23
Redwood City 23
Rio de Janeiro 23
Montreal 22
Pune 22
Vienna 22
Romola 20
San Francisco 20
Stockholm 20
Brasília 19
Frankfurt am Main 19
Guangzhou 19
Leawood 19
Augusta 18
Rome 18
San Mateo 18
Shanghai 18
Toronto 18
Atlanta 17
Council Bluffs 17
Jinan 17
Belo Horizonte 16
Kansas City 16
Boydton 15
Brno 15
Norwalk 15
Boston 14
Curitiba 14
Nuremberg 14
Ardabil 13
Phoenix 13
Tashkent 13
Washington 13
Wuhan 13
Chennai 12
Mumbai 12
Orem 12
Taizhou 12
Zhengzhou 12
Campinas 11
Manchester 11
Sorocaba 11
Amsterdam 10
Guayaquil 10
Langenzersdorf 10
Totale 13.918
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Nome #
ABC pumps and their role in active drug transport 400
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 211
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 201
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 199
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 194
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 189
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 181
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 175
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 174
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 172
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 171
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 171
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 166
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 165
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 164
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 163
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 162
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 160
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 158
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 157
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 156
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 155
5 HT1A receptor, an old target for new therapeutic agents 154
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 151
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 151
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 150
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 149
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 147
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 146
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 145
Cyclohexyl-substituted piperazine compounds 143
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 141
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 139
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 139
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 138
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 138
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 138
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 137
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 136
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 136
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 135
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 134
Activatable fluorescent probes: a new concept in optical molecular imaging 133
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 133
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 132
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 132
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 131
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 131
Le applicazioni della chimica farmaceutica 129
METHOD FOR DETERMINING FREE COPPER 129
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 129
The practice of medicinal chemistry 128
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 127
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 127
An innovative small molecule for promoting neuroreparative strategies 125
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 125
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 122
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 122
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 122
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 122
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 121
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 121
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 120
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 119
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 118
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 117
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 117
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 116
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 116
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 116
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 112
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 112
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 111
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 110
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 109
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 108
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 108
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 108
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 107
Design and synthesis of new selective P-gp substrates and inhibitors. 107
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 107
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 106
Is the sigma-2 receptor a histone binding protein? 106
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 105
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 105
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 105
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 105
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 104
The therapeutic potential of 5-HT1A receptors: a patent review. 104
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 104
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 103
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 103
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 102
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 101
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 101
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 101
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 101
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 101
Totale 13.538
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Categoria #
all - tutte 88.457
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.457
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.350 0 0 0 0 0 99 161 100 155 228 179 428
2021/20221.829 57 243 24 98 125 161 120 84 131 107 299 380
2022/20232.581 460 258 156 216 387 287 25 276 422 20 35 39
2023/2024841 85 157 38 49 64 185 13 17 56 24 18 135
2024/20253.500 162 54 314 138 66 225 308 315 209 178 514 1.017
2025/20263.764 913 391 641 790 655 374 0 0 0 0 0 0
Totale 21.362