IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 13.720
EU - Europa 5.803
AS - Asia 5.277
SA - Sud America 1.283
Continente sconosciuto - Info sul continente non disponibili 235
AF - Africa 214
OC - Oceania 13
Totale 26.545
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Nazione #
US - Stati Uniti d'America 13.406
SG - Singapore 1.974
IT - Italia 1.478
CN - Cina 1.350
DE - Germania 1.071
BR - Brasile 1.025
SE - Svezia 934
RU - Federazione Russa 636
VN - Vietnam 611
HK - Hong Kong 595
GB - Regno Unito 454
UA - Ucraina 327
FI - Finlandia 298
FR - Francia 277
CA - Canada 189
IN - India 158
BD - Bangladesh 121
AR - Argentina 89
MX - Messico 64
CI - Costa d'Avorio 63
IQ - Iraq 55
ID - Indonesia 49
JP - Giappone 46
IE - Irlanda 45
PL - Polonia 45
NL - Olanda 44
CO - Colombia 42
EC - Ecuador 42
TR - Turchia 42
BE - Belgio 40
PK - Pakistan 40
AT - Austria 38
ZA - Sudafrica 38
VE - Venezuela 35
SA - Arabia Saudita 30
UZ - Uzbekistan 26
ES - Italia 25
IR - Iran 23
EG - Egitto 20
CZ - Repubblica Ceca 19
MY - Malesia 19
PH - Filippine 19
MA - Marocco 18
KE - Kenya 15
PY - Paraguay 15
TN - Tunisia 15
CL - Cile 14
JO - Giordania 13
NP - Nepal 13
CR - Costa Rica 12
AU - Australia 11
DZ - Algeria 11
AE - Emirati Arabi Uniti 10
RO - Romania 10
GT - Guatemala 9
IL - Israele 9
JM - Giamaica 9
KZ - Kazakistan 9
TT - Trinidad e Tobago 9
ET - Etiopia 8
AZ - Azerbaigian 7
BO - Bolivia 7
KR - Corea 7
LT - Lituania 7
NG - Nigeria 7
PE - Perù 7
TH - Thailandia 7
EE - Estonia 6
EU - Europa 6
LB - Libano 6
OM - Oman 6
RS - Serbia 6
UY - Uruguay 6
BG - Bulgaria 5
HN - Honduras 5
PS - Palestinian Territory 5
SK - Slovacchia (Repubblica Slovacca) 5
BB - Barbados 4
CH - Svizzera 4
DK - Danimarca 4
GE - Georgia 4
KG - Kirghizistan 4
LY - Libia 4
PT - Portogallo 4
SN - Senegal 4
AL - Albania 3
BH - Bahrain 3
GD - Grenada 3
HU - Ungheria 3
MD - Moldavia 3
PA - Panama 3
QA - Qatar 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
CY - Cipro 2
GR - Grecia 2
HR - Croazia 2
LV - Lettonia 2
MN - Mongolia 2
MU - Mauritius 2
Totale 26.288
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Città #
Fairfield 1.188
Singapore 994
Ashburn 993
Los Angeles 988
Chandler 920
San Jose 818
Woodbridge 813
Jacksonville 735
Hong Kong 587
Nyköping 571
Houston 568
Milan 481
Seattle 455
Wilmington 451
Ann Arbor 429
Beijing 411
Bari 402
Dallas 395
Cambridge 391
Dong Ket 332
Council Bluffs 284
Nanjing 217
Roxbury 213
Lawrence 207
New York 191
Lauterbourg 187
Boardman 182
Rome 151
Princeton 148
Brooklyn 141
Munich 133
Des Moines 126
Ho Chi Minh City 90
Montréal 88
São Paulo 87
Santa Clara 85
Hanoi 70
Helsinki 68
Mcallen 68
Buffalo 65
Inglewood 64
Abidjan 63
Shenyang 62
San Diego 61
Nanchang 58
London 57
Hebei 55
Columbus 51
Jiaxing 50
Chicago 49
Dublin 46
Phoenix 44
Dearborn 43
Tokyo 40
Warsaw 37
Brussels 36
Tianjin 35
Turku 34
Figino 33
North Bergen 33
Montreal 29
Changsha 28
Frankfurt am Main 28
Rio de Janeiro 28
Denver 27
Paris 27
Moscow 26
Atlanta 24
Orem 24
Turin 24
Pune 23
Redwood City 23
Vienna 23
Brasília 22
San Francisco 22
Shanghai 21
Tashkent 21
Baghdad 20
Romola 20
Stockholm 20
Toronto 20
Belo Horizonte 19
Guangzhou 19
Guayaquil 19
Leawood 19
Augusta 18
Curitiba 18
San Mateo 18
Jinan 17
Boston 16
Chennai 16
Dhaka 16
Kansas City 16
Norwalk 16
Washington 16
Amsterdam 15
Boydton 15
Brno 15
Manchester 15
Medellín 15
Totale 17.492
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Nome #
ABC pumps and their role in active drug transport 417
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 297
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 252
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 238
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 225
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 224
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 222
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 221
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 216
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 214
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 210
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 209
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 206
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 201
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 201
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 197
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 195
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 194
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 193
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 191
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 191
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 190
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 188
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 187
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 186
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 185
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 185
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 184
5 HT1A receptor, an old target for new therapeutic agents 183
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 182
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 180
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 180
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 179
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 178
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 178
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 176
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 176
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 176
Is the sigma-2 receptor a histone binding protein? 175
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 174
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 174
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 174
Cyclohexyl-substituted piperazine compounds 173
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 170
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 168
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 168
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 165
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 164
METHOD FOR DETERMINING FREE COPPER 162
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 161
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 161
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 160
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 160
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 158
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 155
Le applicazioni della chimica farmaceutica 155
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 155
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 155
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 154
Activatable fluorescent probes: a new concept in optical molecular imaging 153
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 153
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 153
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 152
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 152
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 150
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 149
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 149
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 148
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 148
The practice of medicinal chemistry 146
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 146
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 146
An innovative small molecule for promoting neuroreparative strategies 145
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 144
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 144
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 144
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 141
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 139
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 136
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 133
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 133
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 130
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 130
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 129
34. Methyl substitution on the piperidine ring of N-[ -(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma-1 receptor 129
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 125
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 125
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 125
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 125
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 124
Design and synthesis of new selective P-gp substrates and inhibitors. 122
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 122
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 122
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 120
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 120
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 120
The therapeutic potential of 5-HT1A receptors: a patent review. 120
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 120
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 119
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 119
Totale 16.798
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Categoria #
all - tutte 103.606
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 103.606
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.529 0 0 24 98 125 161 120 84 131 107 299 380
2022/20232.581 460 258 156 216 387 287 25 276 422 20 35 39
2023/2024841 85 157 38 49 64 185 13 17 56 24 18 135
2024/20253.500 162 54 314 138 66 225 308 315 209 178 514 1.017
2025/20267.213 913 391 641 790 655 412 853 152 630 666 209 901
2026/20271.734 999 412 323 0 0 0 0 0 0 0 0 0
Totale 26.545