IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 11.800
AS - Asia 5.166
EU - Europa 4.946
SA - Sud America 1.262
AF - Africa 212
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 8
Totale 23.405
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Nazione #
US - Stati Uniti d'America 11.529
SG - Singapore 1.949
CN - Cina 1.328
DE - Germania 1.067
BR - Brasile 1.020
SE - Svezia 934
IT - Italia 639
RU - Federazione Russa 636
VN - Vietnam 609
HK - Hong Kong 579
GB - Regno Unito 453
UA - Ucraina 327
FI - Finlandia 298
FR - Francia 276
CA - Canada 167
IN - India 158
AR - Argentina 88
BD - Bangladesh 88
CI - Costa d'Avorio 63
MX - Messico 60
IQ - Iraq 55
ID - Indonesia 46
IE - Irlanda 45
JP - Giappone 45
PL - Polonia 43
NL - Olanda 42
TR - Turchia 41
BE - Belgio 40
PK - Pakistan 40
AT - Austria 38
EC - Ecuador 38
ZA - Sudafrica 38
CO - Colombia 37
VE - Venezuela 31
SA - Arabia Saudita 27
UZ - Uzbekistan 26
IR - Iran 23
ES - Italia 22
EG - Egitto 20
CZ - Repubblica Ceca 18
MA - Marocco 18
MY - Malesia 18
PH - Filippine 18
PY - Paraguay 15
TN - Tunisia 15
CL - Cile 14
KE - Kenya 14
JO - Giordania 13
NP - Nepal 13
DZ - Algeria 11
AE - Emirati Arabi Uniti 10
AU - Australia 9
IL - Israele 9
KZ - Kazakistan 9
RO - Romania 9
CR - Costa Rica 8
ET - Etiopia 8
AZ - Azerbaigian 7
BO - Bolivia 7
GT - Guatemala 7
JM - Giamaica 7
KR - Corea 7
LT - Lituania 7
NG - Nigeria 7
PE - Perù 7
EE - Estonia 6
EU - Europa 6
LB - Libano 6
OM - Oman 6
RS - Serbia 6
BG - Bulgaria 5
PS - Palestinian Territory 5
SK - Slovacchia (Repubblica Slovacca) 5
TH - Thailandia 5
BB - Barbados 4
CH - Svizzera 4
DK - Danimarca 4
GE - Georgia 4
KG - Kirghizistan 4
LY - Libia 4
PT - Portogallo 4
SN - Senegal 4
UY - Uruguay 4
AL - Albania 3
BH - Bahrain 3
GD - Grenada 3
PA - Panama 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
TW - Taiwan 3
CY - Cipro 2
GR - Grecia 2
HN - Honduras 2
HU - Ungheria 2
LV - Lettonia 2
MD - Moldavia 2
MN - Mongolia 2
MU - Mauritius 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
Totale 23.377
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Città #
Fairfield 1.188
Singapore 982
Ashburn 964
Chandler 920
Woodbridge 813
Jacksonville 732
San Jose 599
Hong Kong 571
Nyköping 571
Houston 564
Seattle 455
Wilmington 449
Ann Arbor 429
Beijing 402
Bari 396
Cambridge 390
Dallas 380
Dong Ket 332
Nanjing 217
Roxbury 213
Lawrence 207
Lauterbourg 187
New York 170
Boardman 161
Princeton 148
Brooklyn 138
Munich 133
Des Moines 125
Los Angeles 115
Ho Chi Minh City 89
Montréal 88
São Paulo 85
Hanoi 70
Helsinki 68
Mcallen 68
Inglewood 64
Abidjan 63
Santa Clara 63
Shenyang 62
San Diego 61
Nanchang 58
London 56
Hebei 55
Buffalo 54
Jiaxing 50
Dublin 46
Dearborn 43
Tokyo 39
Brussels 36
Council Bluffs 35
Warsaw 35
Tianjin 34
Turku 34
North Bergen 32
Changsha 28
Rio de Janeiro 28
Montreal 27
Paris 27
Chicago 26
Frankfurt am Main 26
Moscow 26
Denver 24
Orem 24
Pune 23
Redwood City 23
Vienna 23
Rome 22
Atlanta 21
Brasília 21
Tashkent 21
Baghdad 20
Romola 20
San Francisco 20
Shanghai 20
Stockholm 20
Belo Horizonte 19
Guangzhou 19
Leawood 19
Augusta 18
Curitiba 18
Guayaquil 18
San Mateo 18
Toronto 18
Jinan 17
Boston 16
Chennai 16
Kansas City 16
Amsterdam 15
Boydton 15
Brno 15
Dhaka 15
Manchester 15
Mumbai 15
Norwalk 15
Nuremberg 14
Phoenix 14
The Dalles 14
Ardabil 13
Cairo 13
Campinas 13
Totale 15.227
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Nome #
ABC pumps and their role in active drug transport 411
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 227
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 225
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 214
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 211
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 204
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 202
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 191
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 189
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 188
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 183
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 181
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 180
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 178
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 178
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 176
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 172
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 171
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 170
5 HT1A receptor, an old target for new therapeutic agents 170
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 170
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 170
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 168
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 165
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 163
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 162
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 158
Cyclohexyl-substituted piperazine compounds 157
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 155
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 154
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 154
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 153
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 152
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 150
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 150
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 150
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 150
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 149
METHOD FOR DETERMINING FREE COPPER 149
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 147
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 147
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 147
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 146
Le applicazioni della chimica farmaceutica 145
Activatable fluorescent probes: a new concept in optical molecular imaging 145
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 144
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 144
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 144
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 143
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 142
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 140
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 139
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 139
The practice of medicinal chemistry 138
An innovative small molecule for promoting neuroreparative strategies 138
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 138
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 137
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 137
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 137
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 136
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 134
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 134
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 133
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 132
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 130
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 128
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 126
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 125
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 124
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 123
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 121
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 121
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 121
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 118
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 118
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 118
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 116
Design and synthesis of new selective P-gp substrates and inhibitors. 116
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 116
Is the sigma-2 receptor a histone binding protein? 116
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 115
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 115
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 115
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 114
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 114
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 114
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 113
The therapeutic potential of 5-HT1A receptors: a patent review. 113
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 113
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 113
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 111
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 111
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 111
A new class of compounds useful as medicament 110
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 110
34. Methyl substitution on the piperidine ring of N-[ -(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma-1 receptor 110
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 109
Totale 14.838
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Categoria #
all - tutte 92.683
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 92.683
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021835 0 0 0 0 0 0 0 0 0 228 179 428
2021/20221.829 57 243 24 98 125 161 120 84 131 107 299 380
2022/20232.581 460 258 156 216 387 287 25 276 422 20 35 39
2023/2024841 85 157 38 49 64 185 13 17 56 24 18 135
2024/20253.500 162 54 314 138 66 225 308 315 209 178 514 1.017
2025/20266.034 913 391 641 790 655 412 853 152 630 597 0 0
Totale 23.632