IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 9.056
EU - Europa 3.557
AS - Asia 1.525
OC - Oceania 10
SA - Sud America 9
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 4
Totale 14.167
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Nazione #
US - Stati Uniti d'America 8.955
CN - Cina 925
DE - Germania 925
SE - Svezia 899
IT - Italia 545
GB - Regno Unito 363
UA - Ucraina 298
VN - Vietnam 271
SG - Singapore 234
FI - Finlandia 216
RU - Federazione Russa 126
CA - Canada 98
FR - Francia 57
IE - Irlanda 42
IN - India 39
BE - Belgio 37
IR - Iran 22
CZ - Repubblica Ceca 15
NL - Olanda 10
AU - Australia 8
ID - Indonesia 8
JP - Giappone 8
EU - Europa 6
RO - Romania 6
CL - Cile 4
HK - Hong Kong 4
PL - Polonia 4
CH - Svizzera 3
MX - Messico 3
TR - Turchia 3
BG - Bulgaria 2
BR - Brasile 2
ES - Italia 2
GE - Georgia 2
MY - Malesia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PE - Perù 2
PT - Portogallo 2
TH - Thailandia 2
AR - Argentina 1
AT - Austria 1
DK - Danimarca 1
EG - Egitto 1
GR - Grecia 1
IL - Israele 1
KR - Corea 1
KZ - Kazakistan 1
LV - Lettonia 1
PH - Filippine 1
RS - Serbia 1
TW - Taiwan 1
ZW - Zimbabwe 1
Totale 14.167
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Città #
Fairfield 1.184
Chandler 909
Woodbridge 802
Jacksonville 721
Nyköping 562
Houston 543
Ashburn 522
Seattle 445
Wilmington 444
Ann Arbor 417
Cambridge 386
Bari 375
Dong Ket 270
Nanjing 213
Roxbury 209
Lawrence 203
Beijing 196
Singapore 177
Boardman 158
Princeton 147
Des Moines 120
New York 120
Brooklyn 102
Montréal 88
Mcallen 68
Munich 66
Inglewood 64
San Diego 61
Shenyang 58
Nanchang 57
Hebei 55
Jiaxing 50
Dearborn 43
Dublin 42
Brussels 35
Tianjin 32
London 31
Los Angeles 30
Changsha 28
Santa Clara 25
Redwood City 23
Paris 21
Helsinki 20
Leawood 19
Pune 19
Romola 19
San Mateo 18
Guangzhou 17
Augusta 16
Jinan 16
Boydton 15
Brno 15
Norwalk 15
Shanghai 14
Ardabil 13
Kansas City 13
Wuhan 13
Rome 12
Taizhou 11
Zhengzhou 11
Ningbo 10
Frankfurt am Main 9
Indiana 9
Monmouth Junction 9
Wuxi 9
Auburn Hills 8
San Francisco 8
West Jordan 8
Toronto 7
Washington 7
Chiswick 6
Falls Church 6
Hefei 6
Jinhua 6
Yiwu 6
Milan 5
Mumbai 5
Fuzhou 4
Hangzhou 4
Kilburn 4
Marseille 4
Napoli 4
Nuremberg 4
Philadelphia 4
Prescot 4
Quanzhou 4
Strasbourg 4
Sydney 4
Acton 3
Bitonto 3
Bremen 3
Chizhou 3
Detroit 3
Hanover 3
Islington 3
Tokyo 3
Amsterdam 2
Auckland 2
Aveiro 2
Bangalore 2
Totale 10.578
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Nome #
ABC pumps and their role in active drug transport 358
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 153
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 144
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 131
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 131
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 130
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 129
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 127
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 125
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 123
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 118
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 115
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 112
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 110
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 110
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 109
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 109
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 107
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 107
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 106
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 106
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 105
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 105
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 103
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 101
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 100
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 99
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 99
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 98
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 98
5 HT1A receptor, an old target for new therapeutic agents 97
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 97
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 96
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 95
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 95
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 95
The practice of medicinal chemistry 94
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 94
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 94
Le applicazioni della chimica farmaceutica 93
Cyclohexyl-substituted piperazine compounds 93
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 93
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 93
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 92
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 92
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 91
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 90
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 89
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 89
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 88
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 88
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 87
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 87
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 87
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 86
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 86
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 85
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 84
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 84
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 84
Activatable fluorescent probes: a new concept in optical molecular imaging 83
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 83
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 83
The therapeutic potential of 5-HT1A receptors: a patent review. 82
METHOD FOR DETERMINING FREE COPPER 82
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 81
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 81
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 81
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 81
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 81
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 81
Design and synthesis of new selective P-gp substrates and inhibitors. 81
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 81
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 80
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 79
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 79
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 78
A new class of compounds useful as medicament 77
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 77
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 77
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 76
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 75
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 75
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 75
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
Is the sigma-2 receptor a histone binding protein? 74
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 73
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 73
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 73
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 73
An innovative small molecule for promoting neuroreparative strategies 73
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 73
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 72
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 71
Radiosynthesis and in vivo evaluation of [11C]MC80 for P-glycoprotein imaging 71
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 70
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 70
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 69
Conclusions and perspectives 69
null 69
Totale 9.443
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Categoria #
all - tutte 57.334
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 57.334
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.513 0 0 0 280 318 200 367 284 402 228 311 123
2020/20212.076 173 152 165 115 189 99 160 100 153 226 178 366
2021/20221.800 57 239 24 93 125 159 120 83 128 105 296 371
2022/20232.541 451 256 154 213 381 285 24 272 414 19 34 38
2023/2024824 84 155 38 47 64 183 13 15 51 24 16 134
2024/2025535 161 52 308 14 0 0 0 0 0 0 0 0
Totale 14.388