IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 14.755
EU - Europa 5.897
AS - Asia 5.292
SA - Sud America 1.312
Continente sconosciuto - Info sul continente non disponibili 247
AF - Africa 218
OC - Oceania 13
Totale 27.734
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Nazione #
US - Stati Uniti d'America 14.286
SG - Singapore 1.976
IT - Italia 1.535
CN - Cina 1.352
DE - Germania 1.074
BR - Brasile 1.054
SE - Svezia 934
RU - Federazione Russa 654
VN - Vietnam 611
HK - Hong Kong 595
GB - Regno Unito 458
UA - Ucraina 328
FI - Finlandia 298
FR - Francia 279
CA - Canada 242
IN - India 158
BD - Bangladesh 121
AR - Argentina 89
MX - Messico 64
CI - Costa d'Avorio 63
IQ - Iraq 55
ID - Indonesia 49
JP - Giappone 46
PL - Polonia 46
IE - Irlanda 45
NL - Olanda 44
CO - Colombia 42
EC - Ecuador 42
TR - Turchia 42
BE - Belgio 41
PK - Pakistan 40
AT - Austria 39
ZA - Sudafrica 38
VE - Venezuela 35
SA - Arabia Saudita 30
CR - Costa Rica 27
UZ - Uzbekistan 26
ES - Italia 25
GT - Guatemala 24
IR - Iran 23
PH - Filippine 21
EG - Egitto 20
CZ - Repubblica Ceca 19
MY - Malesia 19
TT - Trinidad e Tobago 19
MA - Marocco 18
IL - Israele 17
JM - Giamaica 17
PR - Porto Rico 17
KE - Kenya 15
PY - Paraguay 15
TN - Tunisia 15
CL - Cile 14
SV - El Salvador 14
HN - Honduras 13
JO - Giordania 13
NP - Nepal 13
CW - ???statistics.table.value.countryCode.CW??? 12
AU - Australia 11
DZ - Algeria 11
AE - Emirati Arabi Uniti 10
LT - Lituania 10
RO - Romania 10
KZ - Kazakistan 9
EE - Estonia 8
ET - Etiopia 8
NI - Nicaragua 8
TH - Thailandia 8
AZ - Azerbaigian 7
BO - Bolivia 7
GP - Guadalupe 7
KR - Corea 7
NG - Nigeria 7
PE - Perù 7
EU - Europa 6
LB - Libano 6
OM - Oman 6
RS - Serbia 6
UY - Uruguay 6
BG - Bulgaria 5
DK - Danimarca 5
PS - Palestinian Territory 5
SC - Seychelles 5
SK - Slovacchia (Repubblica Slovacca) 5
BB - Barbados 4
CH - Svizzera 4
GE - Georgia 4
KG - Kirghizistan 4
LY - Libia 4
PT - Portogallo 4
SN - Senegal 4
AL - Albania 3
BH - Bahrain 3
BS - Bahamas 3
GD - Grenada 3
HU - Ungheria 3
MD - Moldavia 3
PA - Panama 3
QA - Qatar 3
SY - Repubblica araba siriana 3
Totale 27.466
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Città #
Ashburn 1.264
Fairfield 1.189
Los Angeles 1.001
Singapore 994
San Jose 979
Chandler 920
Woodbridge 813
Jacksonville 735
Hong Kong 587
Nyköping 571
Houston 568
Milan 485
Seattle 455
Wilmington 451
Ann Arbor 429
Beijing 411
Bari 403
Dallas 398
Cambridge 391
Dong Ket 332
Council Bluffs 284
Nanjing 217
New York 214
Roxbury 213
Lawrence 207
Boardman 196
Lauterbourg 187
Rome 155
Princeton 148
Brooklyn 143
Munich 133
Des Moines 126
São Paulo 114
Santa Clara 96
Ho Chi Minh City 90
Montréal 88
Washington 80
Hanoi 70
Helsinki 68
Mcallen 68
Buffalo 66
Inglewood 64
Abidjan 63
San Diego 62
Shenyang 62
Nanchang 58
London 57
Hebei 55
Phoenix 53
Columbus 52
Jiaxing 50
Chicago 49
Dublin 46
Dearborn 43
Tokyo 40
Warsaw 38
Brussels 37
North Bergen 37
Tianjin 35
Turku 34
Figino 33
Montreal 33
Toronto 33
Frankfurt am Main 29
Atlanta 28
Changsha 28
Rio de Janeiro 28
Turin 28
Denver 27
Paris 27
Moscow 26
Orem 25
Vienna 24
Brasília 23
Pune 23
Redwood City 23
San Francisco 23
Naples 21
Shanghai 21
Tashkent 21
Baghdad 20
Romola 20
Stockholm 20
Belo Horizonte 19
Guangzhou 19
Guayaquil 19
Leawood 19
San José 19
Augusta 18
Curitiba 18
San Mateo 18
Guatemala City 17
Jinan 17
Boston 16
Chennai 16
Dhaka 16
Kansas City 16
Norwalk 16
Amsterdam 15
Boydton 15
Totale 18.151
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Nome #
ABC pumps and their role in active drug transport 422
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 306
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 260
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 243
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 235
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 233
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 232
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 226
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 225
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 220
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 218
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 212
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 212
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 211
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 211
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 209
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 203
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 200
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 199
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 196
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 196
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 194
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 193
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 192
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 190
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 189
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 189
Is the sigma-2 receptor a histone binding protein? 188
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 188
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 187
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 187
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 187
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 187
5 HT1A receptor, an old target for new therapeutic agents 186
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 185
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 184
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 184
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 182
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 181
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 181
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 180
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 179
Cyclohexyl-substituted piperazine compounds 176
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 176
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 174
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 173
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 173
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 169
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 169
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 168
METHOD FOR DETERMINING FREE COPPER 167
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 165
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 164
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 163
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 161
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 160
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 160
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 159
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 158
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 158
Le applicazioni della chimica farmaceutica 157
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 157
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 157
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 156
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 156
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 155
Activatable fluorescent probes: a new concept in optical molecular imaging 155
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 155
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 155
An innovative small molecule for promoting neuroreparative strategies 154
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 153
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 153
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 151
The practice of medicinal chemistry 149
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 149
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 148
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 148
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 146
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 144
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 143
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 142
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 139
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 138
34. Methyl substitution on the piperidine ring of N-[ -(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma-1 receptor 137
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 135
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 135
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 133
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 133
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 129
Design and synthesis of new selective P-gp substrates and inhibitors. 129
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 129
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 128
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 127
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 126
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 125
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 125
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 125
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 125
A new class of compounds useful as medicament 124
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 124
Totale 17.424
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Categoria #
all - tutte 107.725
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 107.725
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.505 0 0 0 98 125 161 120 84 131 107 299 380
2022/20232.581 460 258 156 216 387 287 25 276 422 20 35 39
2023/2024841 85 157 38 49 64 185 13 17 56 24 18 135
2024/20253.500 162 54 314 138 66 225 308 315 209 178 514 1.017
2025/20267.213 913 391 641 790 655 412 853 152 630 666 209 901
2026/20272.923 999 412 531 981 0 0 0 0 0 0 0 0
Totale 27.734