IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 13.063
EU - Europa 5.775
AS - Asia 5.231
SA - Sud America 1.266
AF - Africa 212
OC - Oceania 11
Continente sconosciuto - Info sul continente non disponibili 8
Totale 25.566
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Nazione #
US - Stati Uniti d'America 12.769
SG - Singapore 1.970
IT - Italia 1.457
CN - Cina 1.345
DE - Germania 1.067
BR - Brasile 1.023
SE - Svezia 934
RU - Federazione Russa 636
VN - Vietnam 610
HK - Hong Kong 589
GB - Regno Unito 453
UA - Ucraina 327
FI - Finlandia 298
FR - Francia 277
CA - Canada 177
IN - India 158
BD - Bangladesh 101
AR - Argentina 89
CI - Costa d'Avorio 63
MX - Messico 62
IQ - Iraq 55
ID - Indonesia 47
JP - Giappone 46
IE - Irlanda 45
PL - Polonia 45
NL - Olanda 44
TR - Turchia 41
BE - Belgio 40
PK - Pakistan 40
AT - Austria 38
EC - Ecuador 38
ZA - Sudafrica 38
CO - Colombia 37
VE - Venezuela 31
SA - Arabia Saudita 27
UZ - Uzbekistan 26
ES - Italia 24
IR - Iran 23
EG - Egitto 20
CZ - Repubblica Ceca 19
MA - Marocco 18
MY - Malesia 18
PH - Filippine 18
PY - Paraguay 15
TN - Tunisia 15
CL - Cile 14
KE - Kenya 14
JO - Giordania 13
NP - Nepal 13
DZ - Algeria 11
AE - Emirati Arabi Uniti 10
CR - Costa Rica 10
RO - Romania 10
AU - Australia 9
GT - Guatemala 9
IL - Israele 9
JM - Giamaica 9
KZ - Kazakistan 9
ET - Etiopia 8
AZ - Azerbaigian 7
BO - Bolivia 7
KR - Corea 7
LT - Lituania 7
NG - Nigeria 7
PE - Perù 7
EE - Estonia 6
EU - Europa 6
LB - Libano 6
OM - Oman 6
RS - Serbia 6
BG - Bulgaria 5
HN - Honduras 5
PS - Palestinian Territory 5
SK - Slovacchia (Repubblica Slovacca) 5
TH - Thailandia 5
TT - Trinidad e Tobago 5
BB - Barbados 4
CH - Svizzera 4
DK - Danimarca 4
GE - Georgia 4
KG - Kirghizistan 4
LY - Libia 4
PT - Portogallo 4
SN - Senegal 4
UY - Uruguay 4
AL - Albania 3
BH - Bahrain 3
GD - Grenada 3
HU - Ungheria 3
MD - Moldavia 3
PA - Panama 3
QA - Qatar 3
SY - Repubblica araba siriana 3
TW - Taiwan 3
CY - Cipro 2
GR - Grecia 2
LV - Lettonia 2
MN - Mongolia 2
MU - Mauritius 2
NI - Nicaragua 2
Totale 25.538
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Città #
Fairfield 1.188
Singapore 991
Ashburn 983
Los Angeles 983
Chandler 920
Woodbridge 813
Jacksonville 734
San Jose 669
Hong Kong 581
Nyköping 571
Houston 568
Milan 481
Seattle 455
Wilmington 450
Ann Arbor 429
Beijing 409
Bari 401
Cambridge 391
Dallas 385
Dong Ket 332
Nanjing 217
Roxbury 213
Lawrence 207
Lauterbourg 187
New York 185
Boardman 182
Princeton 148
Rome 146
Brooklyn 140
Munich 133
Des Moines 125
Ho Chi Minh City 90
Montréal 88
São Paulo 86
Hanoi 70
Santa Clara 69
Helsinki 68
Mcallen 68
Inglewood 64
Abidjan 63
Shenyang 62
Buffalo 61
San Diego 61
Nanchang 58
London 57
Hebei 55
Columbus 51
Jiaxing 50
Dublin 46
Dearborn 43
Tokyo 40
Warsaw 37
Brussels 36
Council Bluffs 35
Tianjin 35
Turku 34
Figino 33
North Bergen 33
Changsha 28
Chicago 28
Rio de Janeiro 28
Montreal 27
Paris 27
Denver 26
Frankfurt am Main 26
Moscow 26
Atlanta 24
Orem 24
Turin 24
Pune 23
Redwood City 23
Vienna 23
Brasília 21
Tashkent 21
Baghdad 20
Phoenix 20
Romola 20
San Francisco 20
Shanghai 20
Stockholm 20
Belo Horizonte 19
Guangzhou 19
Leawood 19
Augusta 18
Curitiba 18
Guayaquil 18
San Mateo 18
Toronto 18
Jinan 17
Boston 16
Chennai 16
Dhaka 16
Kansas City 16
Norwalk 16
Amsterdam 15
Boydton 15
Brno 15
Manchester 15
Mumbai 15
Campinas 14
Totale 16.962
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Nome #
ABC pumps and their role in active drug transport 412
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 288
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 245
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 237
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 219
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 219
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 217
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 215
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 214
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 211
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 204
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 200
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 200
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 197
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 197
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 192
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 190
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 190
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 190
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 189
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 189
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 184
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 183
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 183
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 181
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 179
5 HT1A receptor, an old target for new therapeutic agents 179
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 179
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 177
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 176
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 176
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 175
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 175
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 174
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 172
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 172
Cyclohexyl-substituted piperazine compounds 171
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 171
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 170
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 170
Is the sigma-2 receptor a histone binding protein? 169
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 168
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 166
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 166
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 163
"Tritium radiolabeling of [3H]-1-cicloesil-4-[3-(5-methoxy-1,2, 3,4,-tetraidronaftalen-1-il)-n-propil] piperazine ([3H]-PB28)as potent sigma-2 receptor ligand 162
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 160
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 159
METHOD FOR DETERMINING FREE COPPER 158
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 158
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 156
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 154
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 153
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 153
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 152
Le applicazioni della chimica farmaceutica 152
Activatable fluorescent probes: a new concept in optical molecular imaging 152
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 151
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 149
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 149
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 148
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 147
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 147
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 147
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 146
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 146
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and Human Δ(8)-Δ(7) Sterol Isomerase Ligands with Antiproliferative and P-Glycoprotein Inhibitory Activity 146
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 145
The practice of medicinal chemistry 143
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 143
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 142
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 142
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 141
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 141
An innovative small molecule for promoting neuroreparative strategies 141
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 134
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 134
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 131
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 129
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 129
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 129
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 127
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 126
34. Methyl substitution on the piperidine ring of N-[ -(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma-1 receptor 123
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 122
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 122
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 121
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 121
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 121
The therapeutic potential of 5-HT1A receptors: a patent review. 119
A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder 119
Design and synthesis of new selective P-gp substrates and inhibitors. 119
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 119
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 118
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 118
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 118
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 117
Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer 117
A new class of compounds useful as medicament 116
Totale 16.386
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Categoria #
all - tutte 100.453
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 100.453
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.829 57 243 24 98 125 161 120 84 131 107 299 380
2022/20232.581 460 258 156 216 387 287 25 276 422 20 35 39
2023/2024841 85 157 38 49 64 185 13 17 56 24 18 135
2024/20253.500 162 54 314 138 66 225 308 315 209 178 514 1.017
2025/20267.213 913 391 641 790 655 412 853 152 630 666 209 901
2026/2027982 982 0 0 0 0 0 0 0 0 0 0 0
Totale 25.793