IRIS
PERRONE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 9.088
EU - Europa 3.791
AS - Asia 1.676
SA - Sud America 17
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 6
AF - Africa 5
Totale 14.593
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Nazione #
US - Stati Uniti d'America 8.976
CN - Cina 948
DE - Germania 941
SE - Svezia 899
IT - Italia 560
GB - Regno Unito 369
SG - Singapore 353
RU - Federazione Russa 313
UA - Ucraina 298
VN - Vietnam 271
FI - Finlandia 221
CA - Canada 108
FR - Francia 58
IE - Irlanda 43
IN - India 39
BE - Belgio 37
IR - Iran 22
CZ - Repubblica Ceca 15
ID - Indonesia 12
NL - Olanda 11
BR - Brasile 10
AU - Australia 8
HK - Hong Kong 8
JP - Giappone 8
EU - Europa 6
RO - Romania 6
CL - Cile 4
MX - Messico 4
PL - Polonia 4
TR - Turchia 4
CH - Svizzera 3
BG - Bulgaria 2
ES - Italia 2
GE - Georgia 2
LT - Lituania 2
MY - Malesia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
PE - Perù 2
PT - Portogallo 2
TH - Thailandia 2
AR - Argentina 1
AT - Austria 1
DK - Danimarca 1
EG - Egitto 1
GR - Grecia 1
IL - Israele 1
KE - Kenya 1
KR - Corea 1
KZ - Kazakistan 1
LV - Lettonia 1
PH - Filippine 1
RS - Serbia 1
TW - Taiwan 1
ZW - Zimbabwe 1
Totale 14.593
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Città #
Fairfield 1.184
Chandler 909
Woodbridge 802
Jacksonville 721
Nyköping 562
Houston 543
Ashburn 526
Seattle 445
Wilmington 444
Ann Arbor 417
Cambridge 386
Bari 375
Singapore 281
Dong Ket 270
Nanjing 213
Roxbury 209
Lawrence 203
Beijing 196
Boardman 158
Princeton 147
Des Moines 120
New York 120
Brooklyn 102
Montréal 88
Munich 76
Mcallen 68
Inglewood 64
San Diego 61
Shenyang 59
Nanchang 57
Hebei 55
Jiaxing 50
Dearborn 43
Dublin 43
Brussels 35
London 34
Tianjin 32
Los Angeles 30
Changsha 28
Helsinki 25
Santa Clara 25
Redwood City 23
Paris 21
Leawood 19
Pune 19
Romola 19
San Mateo 18
Guangzhou 17
Rome 17
Augusta 16
Jinan 16
Shanghai 16
Boydton 15
Brno 15
Norwalk 15
Toronto 14
Ardabil 13
Frankfurt am Main 13
Kansas City 13
Wuhan 13
Zhengzhou 12
Taizhou 11
Ningbo 10
Indiana 9
Monmouth Junction 9
Wuxi 9
Auburn Hills 8
San Francisco 8
West Jordan 8
Washington 7
Chiswick 6
Falls Church 6
Hefei 6
Jinhua 6
Yiwu 6
Milan 5
Mumbai 5
Nuremberg 5
Fuzhou 4
Hangzhou 4
Hong Kong 4
Jakarta 4
Kilburn 4
Marseille 4
Napoli 4
Philadelphia 4
Prescot 4
Quanzhou 4
Strasbourg 4
Sydney 4
Acton 3
Amsterdam 3
Bitonto 3
Bremen 3
Casoria 3
Chizhou 3
Detroit 3
Hanover 3
Islington 3
Ottawa 3
Totale 10.732
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Nome #
ABC pumps and their role in active drug transport 361
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 157
Bicalutamide failure in prostate cancer treatment: involvement of Multi Drug Resistance proteins 152
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 134
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 133
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 133
Implementing core outcomes in kidney disease: report of the Standardized Outcomes in Nephrology (SONG) implementation workshop 132
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 132
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 129
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 125
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay 123
4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators 119
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 117
1-Phenylalkoxy-2-beta-phenylethyl derivatives as P-gP inhibitors useful in drug resistance events 114
Correlation between sigma2 receptor protein expression and histopathologic grade in human bladder cancer 113
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 111
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum 111
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 109
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 109
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 108
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 107
1-Cyclohexylpiperazine and 3,3-dimethylpiperidine derivatives as sigma-1 and sigma-2 receptor ligand: a review 107
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 106
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 105
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological and diagnostic potentials 103
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 101
5 HT1A receptor, an old target for new therapeutic agents 101
Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors 101
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 101
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 100
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 99
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 99
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 99
Distribution of sigma receptors in EMT-6 cells: preliminary biological evaluation of PB167 and potential for in-vivo PET 97
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 97
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 97
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 97
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 97
The practice of medicinal chemistry 96
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 96
Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives 96
The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells 95
Le applicazioni della chimica farmaceutica 94
Cyclohexyl-substituted piperazine compounds 94
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 94
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 93
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents 92
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 91
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 91
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 90
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 90
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 89
Derivati morfolinici come analoghi semi rigidi di farmaci adrenergici: sintesi e configurazione assoluta di alchilmorfoline 88
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 88
In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays 88
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 87
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 87
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 87
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 87
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 86
Activatable fluorescent probes: a new concept in optical molecular imaging 86
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 86
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 85
METHOD FOR DETERMINING FREE COPPER 85
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 84
The therapeutic potential of 5-HT1A receptors: a patent review. 84
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 83
8-methoxy and p- dimethoxy-1-aminoethylethero-tetralines: synthesis and DA,5HT receptors affinities 83
Design and synthesis of new selective P-gp substrates and inhibitors. 83
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 82
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 82
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 81
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 80
Modulation and absorption of xenobiotics: the synergistic role of CYP450 and P-gp activities in cancer and neurodegenerative disorders 80
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 80
A new class of compounds useful as medicament 79
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 79
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 79
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 78
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 77
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 77
Tyrosine kinase inhibitors and multidrug resistance proteins: interactions and biological consequences 77
An innovative small molecule for promoting neuroreparative strategies 77
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 77
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 76
Is the sigma-2 receptor a histone binding protein? 76
2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties 76
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 75
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 75
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
The potent sigma receptor ligand PB167, as a potential PET radiotracer for evaluating the mammary sarcoma in mice 75
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 74
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 74
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 74
Chemical studies on Drug Metabolism (part II): N-demethylation and N-oxidation of some alicyclic amines by RuO4 73
Radiosynthesis and in vivo evaluation of [11C]MC80 for P-glycoprotein imaging 73
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 72
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 71
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 71
Totale 9.700
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Categoria #
all - tutte 62.320
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.320
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.715 0 0 0 0 0 0 367 284 402 228 311 123
2020/20212.076 173 152 165 115 189 99 160 100 153 226 178 366
2021/20221.800 57 239 24 93 125 159 120 83 128 105 296 371
2022/20232.541 451 256 154 213 381 285 24 272 414 19 34 38
2023/2024824 84 155 38 47 64 183 13 15 51 24 16 134
2024/2025963 161 52 308 136 66 223 17 0 0 0 0 0
Totale 14.816