IRIS
ABATE, CARMEN
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 3.329
EU - Europa 2.535
AS - Asia 371
SA - Sud America 8
Continente sconosciuto - Info sul continente non disponibili 5
AF - Africa 4
OC - Oceania 4
Totale 6.256
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 3.326
DE - Germania 1.048
SE - Svezia 491
GB - Regno Unito 284
IT - Italia 260
RU - Federazione Russa 243
CN - Cina 238
UA - Ucraina 72
VN - Vietnam 69
FI - Finlandia 66
IN - India 26
FR - Francia 19
BE - Belgio 12
IE - Irlanda 12
IR - Iran 12
PL - Polonia 9
CL - Cile 5
RO - Romania 5
AU - Australia 4
ES - Italia 4
NL - Olanda 4
EU - Europa 3
HK - Hong Kong 3
JP - Giappone 3
KR - Corea 3
LY - Libia 3
TR - Turchia 3
A2 - ???statistics.table.value.countryCode.A2??? 2
CA - Canada 2
GE - Georgia 2
ID - Indonesia 2
IL - Israele 2
KZ - Kazakistan 2
MY - Malesia 2
PE - Perù 2
TH - Thailandia 2
AT - Austria 1
BR - Brasile 1
CZ - Repubblica Ceca 1
LK - Sri Lanka 1
LT - Lituania 1
LV - Lettonia 1
MD - Moldavia 1
MX - Messico 1
RS - Serbia 1
TW - Taiwan 1
ZW - Zimbabwe 1
Totale 6.256
Salva come PNG Salva come JPEG
Città #
Chandler 430
Fairfield 413
Woodbridge 297
Nyköping 293
Houston 258
Ashburn 204
Bari 170
Ann Arbor 166
Jacksonville 163
Cambridge 157
Wilmington 155
Seattle 143
Beijing 78
Lawrence 73
Roxbury 70
Dong Ket 69
New York 62
Brooklyn 61
Nanjing 58
Princeton 47
Des Moines 44
Boardman 28
San Diego 26
Hebei 19
London 18
Shenyang 17
Nanchang 14
Inglewood 13
Los Angeles 13
Brussels 12
Dublin 12
Paris 12
Helsinki 11
Pune 11
Jiaxing 10
Kansas City 9
Changsha 8
Falls Church 8
Rome 8
Tianjin 8
Leawood 7
Ardabil 6
Augusta 6
Dearborn 6
San Francisco 6
Sannicandro di Bari 6
Catania 5
Gmina Zabierzów 5
Hanover 5
Indiana 5
Monmouth Junction 5
Norwalk 5
San Mateo 5
Guangzhou 4
Jinan 4
Kilburn 4
Hefei 3
Madrid 3
Milan 3
Ningbo 3
Sabz 3
Taizhou 3
Acquaviva delle Fonti 2
Bangkok 2
Boydton 2
Bucharest 2
Canberra 2
Hounslow 2
Krakow 2
Lima 2
Marseille 2
Nürnberg 2
Philadelphia 2
Polska 2
Redwood City 2
San Jose 2
Tappahannock 2
Tel Aviv 2
Triggiano 2
Washington 2
Acton 1
Almaty 1
Atlanta 1
Baotou 1
Belgrade 1
Biella 1
Bitonto 1
Bordeaux 1
Borås 1
Boston 1
Brierley Hill 1
Brisbane 1
Central 1
Central District 1
Cerignola 1
Chisinau 1
Chiswick 1
Dalian 1
Flensburg 1
Focsani 1
Totale 3.826
Salva come PNG Salva come JPEG
Nome #
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 165
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 146
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 144
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 143
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 130
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 127
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 125
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 124
null 123
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 123
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 122
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging 121
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 121
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 120
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 119
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 116
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 111
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 109
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 106
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 106
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 105
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 104
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor 103
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 102
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 99
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 99
Interaction of chiral MS-245 analogs at h-5-HT6 receptors 97
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 94
Interaction of the Sigma2 Receptor Ligand PB28 with Human Nucleosome 94
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 94
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 93
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 93
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 91
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 90
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 89
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 88
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 88
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 84
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 84
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 83
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 82
null 80
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 80
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 79
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 79
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 79
Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands 78
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 78
null 78
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 77
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 77
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 76
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 72
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 72
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 72
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 71
Is the sigma-2 receptor a histone binding protein? 69
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 68
Lysosomial membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer 67
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 67
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 65
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 64
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. 57
NO1, a new sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines 54
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 43
Why PB28 Could Be a Covid 2019 Game Changer? 37
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 33
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 32
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 27
The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines 25
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 25
Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease 22
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 18
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 15
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 14
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 13
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 12
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 11
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 9
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 8
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 7
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 6
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 5
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 5
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 5
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 3
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 2
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 2
null 2
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 2
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors 1
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 1
Totale 6.501
Salva come PNG Salva come JPEG
Categoria #
all - tutte 22.575
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.575
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019300 0 0 0 0 0 0 0 0 0 0 144 156
2019/20201.173 166 56 78 127 96 52 97 90 108 109 127 67
2020/20211.005 63 116 69 127 78 84 58 44 79 97 71 119
2021/2022847 56 65 10 44 67 128 46 31 66 66 105 163
2022/20231.146 193 161 74 103 124 136 12 114 178 8 18 25
2023/2024354 36 63 22 39 38 102 19 16 3 16 0 0
Totale 6.501