IRIS
ABATE, CARMEN
 Distribuzione geografica
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Continente #
NA - Nord America 7.087
EU - Europa 4.152
AS - Asia 2.791
SA - Sud America 693
Continente sconosciuto - Info sul continente non disponibili 380
AF - Africa 131
OC - Oceania 7
Totale 15.241
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Nazione #
US - Stati Uniti d'America 6.861
DE - Germania 1.183
SG - Singapore 1.083
IT - Italia 968
CN - Cina 646
BR - Brasile 550
RU - Federazione Russa 539
SE - Svezia 503
GB - Regno Unito 355
HK - Hong Kong 298
VN - Vietnam 261
FI - Finlandia 171
FR - Francia 123
CA - Canada 107
IN - India 93
BD - Bangladesh 84
UA - Ucraina 74
ID - Indonesia 54
AR - Argentina 45
JP - Giappone 39
NL - Olanda 39
MX - Messico 36
IQ - Iraq 35
PL - Polonia 34
ES - Italia 32
CO - Colombia 27
ZA - Sudafrica 27
CI - Costa d'Avorio 25
EC - Ecuador 25
TR - Turchia 25
AT - Austria 24
EG - Egitto 19
BE - Belgio 18
IE - Irlanda 18
PK - Pakistan 18
TW - Taiwan 18
KR - Corea 16
IL - Israele 14
MA - Marocco 14
TN - Tunisia 14
MY - Malesia 13
CL - Cile 12
IR - Iran 12
SA - Arabia Saudita 12
PR - Porto Rico 11
PY - Paraguay 11
UZ - Uzbekistan 10
CH - Svizzera 9
CR - Costa Rica 9
SV - El Salvador 9
TT - Trinidad e Tobago 9
VE - Venezuela 9
HN - Honduras 8
NI - Nicaragua 8
AU - Australia 7
CZ - Repubblica Ceca 7
DK - Danimarca 7
KE - Kenya 7
LT - Lituania 7
PE - Perù 7
SC - Seychelles 7
TH - Thailandia 7
EE - Estonia 6
GT - Guatemala 6
PH - Filippine 6
RO - Romania 6
AZ - Azerbaigian 5
JM - Giamaica 5
KZ - Kazakistan 5
PT - Portogallo 5
UY - Uruguay 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
GP - Guadalupe 4
KG - Kirghizistan 4
LY - Libia 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
AL - Albania 3
CW - ???statistics.table.value.countryCode.CW??? 3
DO - Repubblica Dominicana 3
EU - Europa 3
JO - Giordania 3
MN - Mongolia 3
SY - Repubblica araba siriana 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
GE - Georgia 2
GR - Grecia 2
HR - Croazia 2
LB - Libano 2
LC - Santa Lucia 2
LK - Sri Lanka 2
LV - Lettonia 2
PA - Panama 2
PS - Palestinian Territory 2
RS - Serbia 2
SN - Senegal 2
ZW - Zimbabwe 2
AF - Afghanistan, Repubblica islamica di 1
Totale 14.840
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Città #
Los Angeles 1.101
Singapore 555
Ashburn 550
San Jose 464
Chandler 425
Fairfield 413
Woodbridge 297
Nyköping 290
Hong Kong 281
Houston 271
Beijing 235
Milan 230
Council Bluffs 204
Bari 203
Ann Arbor 166
Jacksonville 166
Wilmington 158
Cambridge 157
Seattle 148
Dallas 130
New York 122
Helsinki 104
Rome 86
Lauterbourg 83
Brooklyn 81
Lawrence 73
Roxbury 70
Dong Ket 69
São Paulo 67
Boardman 59
Nanjing 58
Santa Clara 57
Ho Chi Minh City 56
Munich 53
Princeton 47
Des Moines 44
Buffalo 39
Hanoi 37
London 37
Jakarta 36
Columbus 33
Chicago 32
Tokyo 32
Phoenix 31
San Diego 30
Montreal 26
Abidjan 25
Falkenstein 25
Toronto 23
Atlanta 22
Orem 21
Frankfurt am Main 20
North Bergen 20
Hebei 19
Turin 19
Washington 19
Naples 18
Shenyang 18
Warsaw 18
Baghdad 17
San Francisco 17
Denver 16
Dublin 16
Moscow 16
Brasília 15
Brussels 15
Jiaxing 15
Rio de Janeiro 15
Romola 15
Stockholm 15
Belo Horizonte 14
Boston 14
Chennai 14
Florence 14
Nanchang 14
The Dalles 14
Amsterdam 13
Inglewood 13
Johannesburg 13
Nuremberg 13
Catania 12
Figino 12
Paris 12
Pune 12
Turku 12
Curitiba 11
Guangzhou 11
Augusta 10
Haiphong 10
Manchester 10
Mumbai 10
Quito 10
Santiago de Compostela 10
Changsha 9
Kansas City 9
Mexico City 9
Philadelphia 9
Taipei 9
Tashkent 9
Tianjin 9
Totale 8.686
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Nome #
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 306
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 260
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 252
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 249
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 240
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 233
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 231
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 226
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 220
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 220
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 212
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 212
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 208
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 207
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 205
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 203
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 200
Interaction of the Sigma2 Receptor Ligand PB28 with Human Nucleosome 200
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 200
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 199
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 198
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 196
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 196
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 196
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 194
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 193
Interaction of chiral MS-245 analogs at h-5-HT6 receptors 193
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 192
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 189
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 189
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 189
Is the sigma-2 receptor a histone binding protein? 188
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 187
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 187
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 187
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 185
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 182
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 181
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 180
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 180
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 177
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging 176
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 174
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor 174
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 172
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 168
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 160
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 160
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 155
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 155
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 153
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 152
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 152
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 151
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 146
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 140
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 139
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 134
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 133
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 132
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 132
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 127
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 127
Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands 126
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 126
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 125
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 125
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 124
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Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 124
Lysosomial membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer 123
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. 123
NO1, a new sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines 123
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 118
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction 118
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 116
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 113
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 113
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 104
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 97
Why PB28 Could Be a Covid 2019 Game Changer? 92
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 92
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 91
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 88
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 88
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 88
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 85
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PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 78
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 78
The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines 77
Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue 68
Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease 63
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 55
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors 45
Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET 39
Development of Second-Generation Phenoxyethylpiperidines as Potent Sigma-1 Receptor Agonists with Neuroprotective Potential for Alzheimer’s Disease 38
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 32
A Full-Spectrum Evaluation of Sigma-1 Receptor (S1R) Positron Emission Tomography (PET) Radioligands from Binding Affinity to Clinical Imaging 29
Totale 15.161
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Categoria #
all - tutte 52.960
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.960
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022716 0 0 0 44 67 128 46 31 66 66 105 163
2022/20231.138 191 158 74 102 124 135 12 113 178 8 18 25
2023/2024413 36 60 22 38 38 100 19 15 3 16 11 55
2024/20251.925 84 32 152 83 57 168 276 141 89 103 253 487
2025/20264.467 459 248 370 540 432 298 468 145 478 447 156 426
2026/20272.297 1.157 273 301 566 0 0 0 0 0 0 0 0
Totale 15.241