IRIS
ABATE, CARMEN
 Distribuzione geografica
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Continente #
NA - Nord America 4.284
EU - Europa 3.269
AS - Asia 2.042
SA - Sud America 548
AF - Africa 75
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 5
Totale 10.229
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Nazione #
US - Stati Uniti d'America 4.201
DE - Germania 1.154
SG - Singapore 797
CN - Cina 550
RU - Federazione Russa 524
SE - Svezia 496
BR - Brasile 464
IT - Italia 398
GB - Regno Unito 327
HK - Hong Kong 254
VN - Vietnam 195
FI - Finlandia 83
UA - Ucraina 74
IN - India 58
ID - Indonesia 43
CA - Canada 42
FR - Francia 38
AR - Argentina 30
PL - Polonia 28
ES - Italia 26
CI - Costa d'Avorio 24
NL - Olanda 24
AT - Austria 23
MX - Messico 23
BD - Bangladesh 21
JP - Giappone 21
BE - Belgio 15
EG - Egitto 14
IE - Irlanda 14
IQ - Iraq 13
ZA - Sudafrica 13
CO - Colombia 12
EC - Ecuador 12
IR - Iran 12
IL - Israele 9
PY - Paraguay 9
TW - Taiwan 9
KR - Corea 8
TR - Turchia 8
CL - Cile 7
CZ - Repubblica Ceca 7
UZ - Uzbekistan 7
MA - Marocco 6
RO - Romania 6
AU - Australia 5
PE - Perù 5
SA - Arabia Saudita 5
UY - Uruguay 5
CH - Svizzera 4
DK - Danimarca 4
LT - Lituania 4
MY - Malesia 4
PK - Pakistan 4
DO - Repubblica Dominicana 3
EE - Estonia 3
EU - Europa 3
HN - Honduras 3
KE - Kenya 3
KG - Kirghizistan 3
KZ - Kazakistan 3
LY - Libia 3
TN - Tunisia 3
VE - Venezuela 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AE - Emirati Arabi Uniti 2
AZ - Azerbaigian 2
ET - Etiopia 2
GE - Georgia 2
GR - Grecia 2
JO - Giordania 2
LB - Libano 2
MN - Mongolia 2
NI - Nicaragua 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
AF - Afghanistan, Repubblica islamica di 1
AL - Albania 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BY - Bielorussia 1
CR - Costa Rica 1
CW - ???statistics.table.value.countryCode.CW??? 1
DZ - Algeria 1
GD - Grenada 1
GP - Guadalupe 1
HR - Croazia 1
HT - Haiti 1
JM - Giamaica 1
KH - Cambogia 1
KN - Saint Kitts e Nevis 1
LK - Sri Lanka 1
LU - Lussemburgo 1
LV - Lettonia 1
MD - Moldavia 1
ME - Montenegro 1
ML - Mali 1
MR - Mauritania 1
Totale 10.219
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Città #
Chandler 425
Fairfield 413
Singapore 396
Ashburn 373
Woodbridge 297
Nyköping 290
Houston 267
Hong Kong 245
Beijing 214
Bari 191
Ann Arbor 166
Jacksonville 163
Cambridge 157
Wilmington 156
Seattle 146
Dallas 115
New York 77
Brooklyn 74
Lawrence 73
Roxbury 70
Dong Ket 69
Los Angeles 59
Nanjing 58
Munich 53
Princeton 47
São Paulo 46
Des Moines 44
Boardman 41
Ho Chi Minh City 40
Jakarta 36
London 34
Buffalo 31
San Diego 30
Santa Clara 27
Abidjan 24
Chicago 24
Hanoi 21
Hebei 19
Tokyo 19
Shenyang 17
Council Bluffs 16
Helsinki 16
Montreal 16
Moscow 16
Jiaxing 15
Rio de Janeiro 15
Romola 15
Warsaw 15
Brasília 14
Nanchang 14
San Francisco 14
Atlanta 13
Brussels 13
Dublin 13
Inglewood 13
Milan 13
North Bergen 13
Belo Horizonte 12
Boston 12
Falkenstein 12
Nuremberg 12
Paris 12
Pune 12
Turku 12
Denver 11
Frankfurt am Main 11
Guangzhou 11
Phoenix 11
Rome 11
The Dalles 11
Chennai 10
Changsha 9
Curitiba 9
Johannesburg 9
Kansas City 9
Mumbai 9
Columbus 8
Falls Church 8
Santiago de Compostela 8
Stockholm 8
Tanta 8
Tianjin 8
Toronto 8
Vienna 8
Amsterdam 7
Baghdad 7
Catania 7
Leawood 7
Orem 7
Ardabil 6
Augusta 6
Biên Hòa 6
Dearborn 6
Fano 6
Hải Dương 6
Langenzersdorf 6
Manchester 6
Poplar 6
Quito 6
Sannicandro di Bari 6
Totale 5.661
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Nome #
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 208
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 198
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 186
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 185
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 184
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 182
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 179
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 172
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 171
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 170
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 169
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 166
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 164
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 163
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 161
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 161
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 155
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging 154
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 154
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 152
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 150
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 150
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 144
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 144
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 140
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 138
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 138
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 138
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 136
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor 136
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 134
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 131
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 128
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 126
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 125
null 124
Interaction of chiral MS-245 analogs at h-5-HT6 receptors 124
Interaction of the Sigma2 Receptor Ligand PB28 with Human Nucleosome 122
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 121
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 120
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 119
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 118
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 116
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 110
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 110
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 110
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 109
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 107
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 106
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 105
Is the sigma-2 receptor a histone binding protein? 105
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 104
Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands 103
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 103
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 102
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 102
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 101
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 99
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 99
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 96
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 96
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 95
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. 94
Lysosomial membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer 93
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 90
NO1, a new sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines 89
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 86
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 80
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 80
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P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 80
null 79
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 78
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction 74
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 72
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 68
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 68
Why PB28 Could Be a Covid 2019 Game Changer? 68
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 62
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 60
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 60
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 59
The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines 59
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 57
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 54
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 54
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 53
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 51
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 50
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 46
Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease 45
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 38
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 38
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 28
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors 26
Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue 19
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 18
Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET 15
Zervimesine, a Small Sigma-2 Receptor Selective Modulator for Alzheimer’s Disease 2
A Full-Spectrum Evaluation of Sigma-1 Receptor (S1R) Positron Emission Tomography (PET) Radioligands from Binding Affinity to Clinical Imaging 1
Totale 10.592
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Categoria #
all - tutte 41.560
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 41.560
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021552 0 0 0 0 0 84 58 44 79 97 71 119
2021/2022847 56 65 10 44 67 128 46 31 66 66 105 163
2022/20231.138 191 158 74 102 124 135 12 113 178 8 18 25
2023/2024413 36 60 22 38 38 100 19 15 3 16 11 55
2024/20251.925 84 32 152 83 57 168 276 141 89 103 253 487
2025/20262.116 459 248 370 540 432 67 0 0 0 0 0 0
Totale 10.593