IRIS
ABATE, CARMEN
 Distribuzione geografica
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Continente #
NA - Nord America 6.148
EU - Europa 3.995
AS - Asia 2.751
SA - Sud America 670
AF - Africa 123
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 6
Totale 13.700
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Nazione #
US - Stati Uniti d'America 6.022
DE - Germania 1.178
SG - Singapore 1.078
IT - Italia 862
CN - Cina 643
BR - Brasile 537
RU - Federazione Russa 527
SE - Svezia 503
GB - Regno Unito 342
HK - Hong Kong 296
VN - Vietnam 261
FI - Finlandia 171
FR - Francia 120
IN - India 93
UA - Ucraina 74
BD - Bangladesh 68
CA - Canada 58
ID - Indonesia 52
AR - Argentina 45
JP - Giappone 39
NL - Olanda 37
MX - Messico 36
IQ - Iraq 35
PL - Polonia 34
ES - Italia 27
ZA - Sudafrica 27
CI - Costa d'Avorio 25
TR - Turchia 25
AT - Austria 24
CO - Colombia 24
EC - Ecuador 21
EG - Egitto 19
BE - Belgio 18
IE - Irlanda 18
PK - Pakistan 18
TW - Taiwan 18
KR - Corea 15
MA - Marocco 14
TN - Tunisia 14
MY - Malesia 13
CL - Cile 12
IR - Iran 12
SA - Arabia Saudita 12
PY - Paraguay 11
UZ - Uzbekistan 10
CH - Svizzera 9
IL - Israele 9
AU - Australia 7
CZ - Repubblica Ceca 7
VE - Venezuela 7
CR - Costa Rica 6
KE - Kenya 6
PE - Perù 6
RO - Romania 6
AZ - Azerbaigian 5
DK - Danimarca 5
PH - Filippine 5
PT - Portogallo 5
UY - Uruguay 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
HN - Honduras 4
JM - Giamaica 4
KG - Kirghizistan 4
KZ - Kazakistan 4
LT - Lituania 4
LY - Libia 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
AL - Albania 3
DO - Repubblica Dominicana 3
EE - Estonia 3
EU - Europa 3
JO - Giordania 3
MN - Mongolia 3
NI - Nicaragua 3
SY - Repubblica araba siriana 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
GE - Georgia 2
GR - Grecia 2
LB - Libano 2
LV - Lettonia 2
PA - Panama 2
PS - Palestinian Territory 2
SN - Senegal 2
ZW - Zimbabwe 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BT - Bhutan 1
BY - Bielorussia 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
GD - Grenada 1
Totale 13.676
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Città #
Los Angeles 1.090
Singapore 552
Ashburn 461
Chandler 425
Fairfield 413
San Jose 321
Woodbridge 297
Nyköping 290
Hong Kong 279
Houston 269
Beijing 233
Milan 221
Bari 200
Ann Arbor 166
Jacksonville 166
Wilmington 158
Cambridge 157
Seattle 147
Dallas 126
New York 107
Helsinki 104
Lauterbourg 83
Brooklyn 77
Lawrence 73
Rome 73
Roxbury 70
Dong Ket 69
Nanjing 58
São Paulo 58
Ho Chi Minh City 56
Boardman 53
Munich 53
Princeton 47
Des Moines 44
Council Bluffs 40
Santa Clara 40
Buffalo 37
Hanoi 37
London 37
Jakarta 36
Columbus 33
Tokyo 32
San Diego 30
Chicago 28
Abidjan 25
Falkenstein 25
Montreal 22
Orem 21
Frankfurt am Main 20
Hebei 19
Shenyang 18
Warsaw 18
Atlanta 17
Baghdad 17
Denver 16
Dublin 16
Moscow 16
San Francisco 16
Turin 16
Brasília 15
Brussels 15
Jiaxing 15
Phoenix 15
Rio de Janeiro 15
Romola 15
Stockholm 15
Belo Horizonte 14
Chennai 14
Nanchang 14
Toronto 14
Amsterdam 13
Boston 13
Inglewood 13
Johannesburg 13
North Bergen 13
Nuremberg 12
Paris 12
Pune 12
The Dalles 12
Turku 12
Catania 11
Curitiba 11
Figino 11
Florence 11
Guangzhou 11
Haiphong 10
Manchester 10
Mumbai 10
Naples 10
Augusta 9
Changsha 9
Kansas City 9
Mexico City 9
Taipei 9
Tashkent 9
Tianjin 9
Vienna 9
Da Nang 8
Falls Church 8
Philadelphia 8
Totale 8.105
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Nome #
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 288
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 245
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 233
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 232
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 222
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 217
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 215
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 214
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 213
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 211
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 204
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 200
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 199
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 197
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 193
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 192
Interaction of the Sigma2 Receptor Ligand PB28 with Human Nucleosome 191
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 191
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 190
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 189
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 189
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 188
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 185
Interaction of chiral MS-245 analogs at h-5-HT6 receptors 184
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 183
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 183
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 183
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 181
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 181
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 179
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 177
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 176
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 175
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 174
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 172
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging 171
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 171
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 170
Is the sigma-2 receptor a histone binding protein? 169
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 168
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor 166
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 166
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 163
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 161
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 159
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 158
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 148
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 146
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 146
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 145
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 141
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 139
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 139
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 137
Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 132
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 128
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 126
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P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 124
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 123
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 121
Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands 120
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 120
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 119
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 118
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 118
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 112
Lysosomial membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer 112
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 112
NO1, a new sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines 112
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 109
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. 109
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 108
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 103
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 102
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 99
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction 97
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 87
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 84
Why PB28 Could Be a Covid 2019 Game Changer? 82
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New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 79
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 78
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 78
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 77
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 76
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 74
The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines 70
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 70
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 67
Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease 58
Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue 55
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 51
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors 38
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 28
Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET 23
A Full-Spectrum Evaluation of Sigma-1 Receptor (S1R) Positron Emission Tomography (PET) Radioligands from Binding Affinity to Clinical Imaging 19
Development of Second-Generation Phenoxyethylpiperidines as Potent Sigma-1 Receptor Agonists with Neuroprotective Potential for Alzheimer’s Disease 17
Totale 14.045
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Categoria #
all - tutte 49.078
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 49.078
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022847 56 65 10 44 67 128 46 31 66 66 105 163
2022/20231.138 191 158 74 102 124 135 12 113 178 8 18 25
2023/2024413 36 60 22 38 38 100 19 15 3 16 11 55
2024/20251.925 84 32 152 83 57 168 276 141 89 103 253 487
2025/20264.467 459 248 370 540 432 298 468 145 478 447 156 426
2026/20271.126 1.126 0 0 0 0 0 0 0 0 0 0 0
Totale 14.070