IRIS
ABATE, CARMEN
 Distribuzione geografica
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Continente #
NA - Nord America 4.875
EU - Europa 3.592
AS - Asia 2.693
SA - Sud America 660
AF - Africa 123
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 6
Totale 11.956
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Nazione #
US - Stati Uniti d'America 4.761
DE - Germania 1.177
SG - Singapore 1.068
CN - Cina 623
BR - Brasile 534
RU - Federazione Russa 527
SE - Svezia 503
IT - Italia 472
GB - Regno Unito 341
HK - Hong Kong 288
VN - Vietnam 261
FI - Finlandia 171
FR - Francia 119
IN - India 93
UA - Ucraina 74
CA - Canada 54
ID - Indonesia 52
BD - Bangladesh 51
AR - Argentina 43
JP - Giappone 39
IQ - Iraq 35
MX - Messico 35
PL - Polonia 34
NL - Olanda 31
ES - Italia 27
ZA - Sudafrica 27
CI - Costa d'Avorio 25
TR - Turchia 25
AT - Austria 24
CO - Colombia 21
EC - Ecuador 21
EG - Egitto 19
BE - Belgio 18
PK - Pakistan 18
TW - Taiwan 18
IE - Irlanda 17
KR - Corea 15
MA - Marocco 14
TN - Tunisia 14
MY - Malesia 13
CL - Cile 12
IR - Iran 12
SA - Arabia Saudita 12
PY - Paraguay 10
UZ - Uzbekistan 10
IL - Israele 9
AU - Australia 7
CZ - Repubblica Ceca 7
VE - Venezuela 7
CH - Svizzera 6
KE - Kenya 6
RO - Romania 6
AZ - Azerbaigian 5
DK - Danimarca 5
PE - Perù 5
PH - Filippine 5
PT - Portogallo 5
UY - Uruguay 5
AE - Emirati Arabi Uniti 4
CR - Costa Rica 4
ET - Etiopia 4
HN - Honduras 4
KG - Kirghizistan 4
KZ - Kazakistan 4
LT - Lituania 4
LY - Libia 4
OM - Oman 4
SK - Slovacchia (Repubblica Slovacca) 4
TH - Thailandia 4
AL - Albania 3
DO - Repubblica Dominicana 3
EE - Estonia 3
EU - Europa 3
JM - Giamaica 3
JO - Giordania 3
MN - Mongolia 3
A2 - ???statistics.table.value.countryCode.A2??? 2
DZ - Algeria 2
GE - Georgia 2
GR - Grecia 2
LB - Libano 2
LV - Lettonia 2
NI - Nicaragua 2
PA - Panama 2
PS - Palestinian Territory 2
SN - Senegal 2
ZW - Zimbabwe 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BG - Bulgaria 1
BH - Bahrain 1
BT - Bhutan 1
BY - Bielorussia 1
CW - ???statistics.table.value.countryCode.CW??? 1
CY - Cipro 1
GD - Grenada 1
GP - Guadalupe 1
Totale 11.936
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Città #
Singapore 545
Ashburn 446
Chandler 425
Fairfield 413
Woodbridge 297
Nyköping 290
San Jose 290
Hong Kong 271
Houston 268
Beijing 222
Bari 192
Ann Arbor 166
Jacksonville 164
Cambridge 157
Wilmington 156
Seattle 146
Dallas 123
Helsinki 104
New York 89
Lauterbourg 83
Brooklyn 75
Lawrence 73
Los Angeles 72
Roxbury 70
Dong Ket 69
Nanjing 58
São Paulo 57
Ho Chi Minh City 56
Munich 53
Princeton 47
Des Moines 44
Boardman 41
Council Bluffs 40
Hanoi 37
Jakarta 36
London 36
Buffalo 33
Santa Clara 33
Tokyo 32
San Diego 30
Chicago 27
Abidjan 25
Falkenstein 25
Montreal 22
Orem 21
Frankfurt am Main 19
Hebei 19
Rome 18
Shenyang 18
Warsaw 18
Baghdad 17
Atlanta 16
Dublin 16
Moscow 16
San Francisco 16
Brasília 15
Brussels 15
Denver 15
Jiaxing 15
Rio de Janeiro 15
Romola 15
Stockholm 15
Belo Horizonte 14
Chennai 14
Nanchang 14
Boston 13
Inglewood 13
Johannesburg 13
Milan 13
North Bergen 13
Amsterdam 12
Nuremberg 12
Paris 12
Phoenix 12
Pune 12
Turku 12
Curitiba 11
Guangzhou 11
The Dalles 11
Haiphong 10
Mumbai 10
Toronto 10
Catania 9
Changsha 9
Kansas City 9
Manchester 9
Taipei 9
Tashkent 9
Vienna 9
Columbus 8
Da Nang 8
Falls Church 8
Mexico City 8
Quito 8
Salt Lake City 8
Santiago de Compostela 8
Tanta 8
Tianjin 8
Augusta 7
Guayaquil 7
Totale 6.628
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Nome #
The effects of new sigma (σ) receptor ligands, PB190 and PB212, in the models predictive of antidepressant activity. 226
1-Cyclohexylpiperazine and 3,3-Dimethylpiperidine Derivatives as Sigma-1 (σ1) and Sigma-2 (σ2) Receptor Ligands: A Review 225
Perspectives of Cannabinoid Type 2 Receptor (CB2R) Ligands in Neurodegenerative Disorders: Structure–Affinity Relationship (SAfiR) and Structure–Activity Relationship (SAR) Studies 210
1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Delta8─Delta7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity 204
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 202
Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate Pglycoprotein (P-gp) activity from σ2 receptor affinity in mixed P-gp/σ2 receptor agents 201
Novel and Selective Fluorescent σ2-Receptor Ligand with a 3,4-Dihydroisoquinolin-1-one Scaffold: A Tool to Study σ2 Receptors in Living Cells 191
Arylamides hybrids of two high-affinity sigma-2 receptor ligands as tools for the development of PET radiotracers 190
Collateral Sensitivity of sigma2 Receptor ligands: Potentials in the Treatment of Multidrug Resistant Tumors 189
Synthesis and pharmacological evaluation of 11C-labeled piperazine derivative as a PET probe for sigma-2 receptor imaging 185
Development of sigma-1 (σ1) receptor fluorescent ligands as versatile tools to study σ1 receptors 185
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 182
4-(Tetralin-1-yl)- and 4-(Naphthalen-1-yl)alkyl Derivatives of 1-Cycloheylpiperazine as sigma receptor Ligands with Agonist sigma 2 Activity 180
Sigma 2 receptor expression levels in blood and bladder from healthy and bladder cancer cattle 178
From mixed sigma-2 receptor/P-glycoprotein targeting agents to selective P-glycoprotein modulators: small structural changes address the mechanism of interaction at the efflux pump 178
Sigma-2 receptor agonists as possible antitumor agents in resistant tumors: Hints for collateral sensitivity 176
Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer 174
A Structure-Affinity and Comparative Molecular Field Analysis of Sigma-2 (σ2) Receptor Ligands 172
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 172
Mrp1-collateral sensitizers as a novel therapeutic approach in resistant cancer therapy: An in vitro and in vivo study in lung resistant tumor 172
2-Aminopyridine derivatives as potential sigma2 receptor antagonists 170
Live imaging reveals a new role for the sigma-1 (σ1) receptor in allowing microglia to leave brain injuries 168
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 receptor ligands to PGRMC1 166
Quantum Dot Based Luminescent Nanoprobes for Sigma-2 Receptor Imaging 164
Classes of sigma2 ( o-2) receptor ligands: structure affinity relationship (SAfiR) studies and antiproliferative activity 163
Cannabinoid Receptor Subtype 2 (CB2R) in a Multitarget Approach: Perspective of an Innovative Strategy in Cancer and Neurodegeneration 160
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma 157
Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor 157
The sigma-1 receptor antagonist PB212 reduces the Ca2+-release through the inositol (1, 4, 5)-triphosphate receptor in SK-N-SH cells 156
Antiproliferative and cytotoxic effects of some sigma-2 agonists and sigma-1 antagonists in tumour cell lines 153
TRITIUM RADIOLABELING OF [3H]-1-CYCLOHEXYL-4-[3-(5-METHOXY-1,2, 3,4,-TETRAHYDRONAPHTHALEN-1-YL)-N-PROPYL]PIPERAZINE ([3H]-PB28), AS A POTENT SIGMA-2 RECEPTOR LIGAND 150
Investigation of sigma receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines 147
Exploring the importance of piperazine N-atoms for sigma-2 receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) 144
Novel Metal Chelators Thiosemicarbazones with Activity at the sigma2 Receptors and P-glycoprotein: an Innovative Strategy for Resistant Tumors Treatment 142
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 139
Validation of Thiosemicarbazone Compounds as P-Glycoprotein Inhibitors in Human Primary Brain-Blood Barrier and Glioblastoma Stem Cells 139
Interaction of the sigma-2 receptor ligand PB28 with the human nucleosome: computational and experimental probes of interaction with the H2A/H2B dimer 137
Design and evaluation of naphthol- and carbazole- containing fluorescent sigma ligands as potential probes for receptor binding studies 137
The controversial identity of the sigma-2 receptor with PGRMC1: is the PGRMC1/sigma-2 protein, that binds Abeta oligomer, made of two independent molecular entities? 134
Interaction of the Sigma2 Receptor Ligand PB28 with Human Nucleosome 133
Interaction of chiral MS-245 analogs at h-5-HT6 receptors 132
First-In-Class Thiosemicarbazone Metal Complexes Targeting the Sigma-2 Receptor (S2R) as an Innovative Strategy against Pancreatic Cancer 130
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms 129
Elements in support of the 'non-identity' of the PGRMC1 protein with the σ2 receptor 126
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma1 receptor 125
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as sigma-1 receptor ligands 125
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Synthesis and pharmacological evaluation of methyl and fluoroethyl piperazine analogues as PET probes for sigma receptor imaging. 122
Sintesi di [3H]-1-cicloesil-4-[3-(5-metossi-1,2,3,4-tetraidronaftalen-1-il)-n-propil]piperazina ([3H]-PB28) il primo potente e selettivo strumento farmacologico nella valutazione biologica di recettori sigma-2 121
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 121
Multifunctional thiosemicarbazones and deconstructed analogues as a strategy to study the involvement of metal chelation, Sigma-2 (Ï 2) receptor and P-gp protein in the cytotoxic action: In vitro and in vivo activity in pancreatic tumors 120
Tritium radiolabeling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization 116
Effects of PB190 and PB212, new sigma receptor ligands, on glucocorticoid receptor-mediated gene transcription in LMCAT cells 116
Tritium radiolabeling of [3H]-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-n-propyl]piperazine ([3H]-PB28), as a potent sigma-2 receptor ligand 116
Is the sigma-2 receptor a histone binding protein? 116
Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracer 115
Sigma Receptor Research: Progress Towards Diagnostic and Therapeutic Uses of Sigma Ligands 114
Fluorescent Derivatives of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a Tool for Uptake and Cellular Localization Studies in Pancreatic Tumor Cells 114
Exploring the binding at sigma-1 receptor subtype: newly prepared heterocyclic omega-(1-alkyl)-derivatives of 3,3-dimethylpiperidine 113
P-Glycoprotein, a biological and medicinal chemistry/radiochemistry point of view 112
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 111
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 110
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 109
Lysosomial membrane permeabilization is an early event in sigma-2 receptor ligand mediated cell death in pancreatic cancer 109
Synthesis, radiolabelling, and evaluation of [11C]PB212 as a radioligand for imaging sigma-1 receptors using PET. 108
NO1, a new sigma 2 receptor/TMEM97 fluorescent ligand, downregulates SOCE and promotes apoptosis in the triple negative breast cancer cell lines 108
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 107
Society for Neuroscience Annual Meeting; Nanosymposium: Sigma-2/PGRMC1 Receptor Function in Disease and Therapeutics 106
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 104
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of sigma-2 receptors 104
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 103
The Role of Cannabinoid Receptors Subtype 2 inCancer A Promising Therapeutical Target 103
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 102
New potential Sigma Ligands for P.E.T.: Isosteric changes on PB28 alkyl chain 100
Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-Based Techniques 93
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 91
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction 91
Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97 89
N‑Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R) 81
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Why PB28 Could Be a Covid 2019 Game Changer? 78
Multi‐target directed ligands (Mtdls) binding the σ1 receptor as promising therapeutics: State of the art and perspectives 76
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 75
Sigma-2 receptor: Past, present and perspectives on multiple therapeutic exploitations 71
The σ1 receptor agonist (+)-pentazocine increases store-operated Ca2+ entry in MCF7σ1 and SK-N-SH cell lines 69
New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4 68
Cannabinoid receptor subtype 2 (CB2R): Features and targets for medical applications 67
Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells 65
PB28, the Sigma-1 and Sigma-2 Receptors Modulator With Potent Anti–SARS-CoV-2 Activity: A Review About Its Pharmacological Properties and Structure Affinity Relationships 59
σ2 receptor and its role in cancer with focus on a multitarget directed ligand (Mtdl) approach 59
Proceedings from the Fourth International Symposium on sigma-2 Receptors: Role in Health and Disease 56
CC48 a new CB2R agonist/FAAH inhibitor dual drug blocks gastric cancer progression and overcomes paclitaxel resistance 53
Multifunctional thiosemicarbazones targeting sigma receptors: in vitro and in vivo antitumor activities in pancreatic cancer models 50
Healthy BRCA1/2 mutation carriers exhibit a pre-CAF signature and altered epithelial marker expression in breast tissue 40
Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[18F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA Receptors 36
The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0 27
Discriminative stimulus properties of α-ethyltryptamine (α-ET) in rats: α-ET-like effects of MDMA, MDA and aryl-monomethoxy substituted derivatives of α-ET 23
A Full-Spectrum Evaluation of Sigma-1 Receptor (S1R) Positron Emission Tomography (PET) Radioligands from Binding Affinity to Clinical Imaging 16
Zervimesine, a Small Sigma-2 Receptor Selective Modulator for Alzheimer’s Disease 12
Totale 12.303
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Categoria #
all - tutte 44.710
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.710
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021287 0 0 0 0 0 0 0 0 0 97 71 119
2021/2022847 56 65 10 44 67 128 46 31 66 66 105 163
2022/20231.138 191 158 74 102 124 135 12 113 178 8 18 25
2023/2024413 36 60 22 38 38 100 19 15 3 16 11 55
2024/20251.925 84 32 152 83 57 168 276 141 89 103 253 487
2025/20263.847 459 248 370 540 432 298 468 145 478 409 0 0
Totale 12.324