IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 3.345
EU - Europa 924
AS - Asia 439
AF - Africa 6
SA - Sud America 4
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 1
Totale 4.721
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Nazione #
US - Stati Uniti d'America 3.343
CN - Cina 327
SE - Svezia 275
IT - Italia 184
DE - Germania 164
UA - Ucraina 66
FI - Finlandia 57
GB - Regno Unito 47
FR - Francia 33
IN - India 31
IR - Iran 26
BE - Belgio 24
SG - Singapore 23
IE - Irlanda 19
ES - Italia 17
RU - Federazione Russa 17
VN - Vietnam 8
NL - Olanda 6
TR - Turchia 6
KR - Corea 5
CH - Svizzera 4
CZ - Repubblica Ceca 4
JP - Giappone 4
EG - Egitto 3
MA - Marocco 3
EU - Europa 2
IL - Israele 2
IQ - Iraq 2
PL - Polonia 2
TW - Taiwan 2
AN - Antille olandesi 1
AU - Australia 1
BG - Bulgaria 1
BR - Brasile 1
CA - Canada 1
CL - Cile 1
EC - Ecuador 1
HK - Hong Kong 1
HU - Ungheria 1
IS - Islanda 1
NP - Nepal 1
PE - Perù 1
PH - Filippine 1
PT - Portogallo 1
RO - Romania 1
Totale 4.721
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Città #
Fairfield 448
Chandler 352
Woodbridge 326
Ashburn 256
Nyköping 222
Seattle 192
Houston 186
Cambridge 178
Ann Arbor 170
Wilmington 160
Jacksonville 151
Bari 78
Roxbury 73
Lawrence 69
Beijing 61
Nanjing 56
Boardman 50
New York 48
Des Moines 47
Princeton 35
Brooklyn 32
Dearborn 30
Inglewood 27
Brussels 24
Milan 20
Nanchang 20
San Diego 20
Dublin 19
Marseille 17
Shenyang 17
Hebei 16
Jiaxing 16
Leawood 14
Singapore 13
Ardabil 12
Helsinki 12
Shanghai 11
Guangzhou 10
Los Angeles 10
West Jordan 10
Kansas City 9
Paris 9
San Mateo 9
Augusta 8
London 8
Munich 8
Tianjin 8
Dong Ket 7
Norwalk 7
Santa Marinella 7
Washington 7
Wuhan 7
Indiana 6
Jinhua 6
San Francisco 6
Tehran 6
Terlizzi 6
Falls Church 5
Kunming 5
Moscow 5
Wuxi 5
Boydton 4
Brno 4
Changsha 4
Delhi 4
Guwahati 4
Jinan 4
Napoli 4
Pune 4
Shenzhen 4
Almere Stad 3
Azrou 3
Chicago 3
Hefei 3
Hounslow 3
Irpin 3
Izmir 3
Kolkata 3
La Canada Flintridge 3
New Delhi 3
Ningbo 3
Redwood City 3
Taizhou 3
Visakhapatnam 3
Baghdad 2
Bhubaneswar 2
Camerino 2
Chengdu 2
Dalian 2
Florence 2
Harrow 2
Ismailia 2
Lucknow 2
Lugano 2
Mola di Bari 2
Monmouth Junction 2
Nürnberg 2
Osaka 2
Pescara 2
Qingdao 2
Totale 3.762
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Nome #
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 135
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 130
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 126
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 125
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 119
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 118
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 117
Protein crystallography and fragment-based drug design 111
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 111
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 108
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 105
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 103
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 102
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 97
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 93
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 90
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 90
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 90
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 87
Organofluorine-containing therapeutics for treatment of cardiovascular disease 87
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 87
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 80
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 79
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 74
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 73
Novel factor Xa inhibitors: a patent review 72
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 68
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 65
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 65
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 64
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 63
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 63
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 63
null 60
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 60
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 60
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 59
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 58
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 57
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 56
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 55
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 55
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 54
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 54
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 54
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 53
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 50
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 49
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 48
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 48
Antiplatelet activity of nipecotic acid derivatives 48
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 48
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 47
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 46
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 46
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 45
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 43
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 43
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 41
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 39
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 39
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 36
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 35
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 32
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 31
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 30
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 24
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 24
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 23
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 22
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 22
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 22
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 19
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 19
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 19
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 18
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 17
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 12
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The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 9
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 9
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 7
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 7
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 7
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 6
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 6
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 5
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 4
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 3
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 3
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 2
A Critical Appraisal of the Protecting Activity of Polyphenolic Antioxidants Against Iatrogenic Effects of Anticancer Chemotherapeutics§ 2
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 1
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 1
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 1
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 1
Totale 4.965
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Categoria #
all - tutte 21.307
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.307
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020928 0 51 30 108 101 98 119 96 120 74 99 32
2020/2021850 88 83 60 78 80 34 64 54 83 91 92 43
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.034 151 115 53 79 146 100 13 133 165 27 30 22
2023/2024527 34 59 32 51 38 97 33 19 22 24 18 100
2024/202585 60 25 0 0 0 0 0 0 0 0 0 0
Totale 4.965