IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 5.894
AS - Asia 2.492
EU - Europa 2.200
SA - Sud America 638
Continente sconosciuto - Info sul continente non disponibili 354
AF - Africa 104
OC - Oceania 6
Totale 11.688
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Nazione #
US - Stati Uniti d'America 5.769
SG - Singapore 876
IT - Italia 698
CN - Cina 592
BR - Brasile 493
HK - Hong Kong 303
SE - Svezia 287
RU - Federazione Russa 280
DE - Germania 279
VN - Vietnam 185
FR - Francia 155
GB - Regno Unito 120
IN - India 108
FI - Finlandia 97
BD - Bangladesh 87
UA - Ucraina 76
CA - Canada 54
ID - Indonesia 51
AR - Argentina 42
JP - Giappone 38
ES - Italia 35
IQ - Iraq 30
BE - Belgio 28
IR - Iran 28
MX - Messico 28
TR - Turchia 28
CO - Colombia 27
EC - Ecuador 27
IE - Irlanda 25
NL - Olanda 25
ZA - Sudafrica 24
PL - Polonia 23
VE - Venezuela 20
CI - Costa d'Avorio 19
SA - Arabia Saudita 18
PH - Filippine 16
PK - Pakistan 16
AT - Austria 15
MA - Marocco 15
KR - Corea 13
UZ - Uzbekistan 13
EG - Egitto 11
CL - Cile 10
JM - Giamaica 10
KZ - Kazakistan 10
AE - Emirati Arabi Uniti 9
DZ - Algeria 9
JO - Giordania 9
CZ - Repubblica Ceca 8
LT - Lituania 8
MY - Malesia 8
PE - Perù 8
TN - Tunisia 8
AZ - Azerbaigian 7
KE - Kenya 7
NP - Nepal 7
CR - Costa Rica 6
EE - Estonia 6
IL - Israele 6
TW - Taiwan 6
AU - Australia 5
CH - Svizzera 5
PA - Panama 5
TH - Thailandia 5
BY - Bielorussia 4
ET - Etiopia 4
KG - Kirghizistan 4
PY - Paraguay 4
TT - Trinidad e Tobago 4
BH - Bahrain 3
BO - Bolivia 3
HN - Honduras 3
LB - Libano 3
NI - Nicaragua 3
PT - Portogallo 3
RO - Romania 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
UY - Uruguay 3
BG - Bulgaria 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EU - Europa 2
GR - Grecia 2
MD - Moldavia 2
MN - Mongolia 2
OM - Oman 2
PS - Palestinian Territory 2
SN - Senegal 2
SV - El Salvador 2
XK - ???statistics.table.value.countryCode.XK??? 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AL - Albania 1
AN - Antille olandesi 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BM - Bermuda 1
BN - Brunei Darussalam 1
Totale 11.319
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Città #
Ashburn 608
Fairfield 448
Singapore 440
San Jose 411
Chandler 350
Woodbridge 326
Hong Kong 286
Milan 248
Nyköping 220
Seattle 203
Houston 196
Cambridge 178
Ann Arbor 170
Beijing 165
Council Bluffs 165
Wilmington 165
Jacksonville 153
Dallas 125
New York 106
Bari 86
Boardman 83
Santa Clara 74
Roxbury 73
Lauterbourg 72
Los Angeles 71
Lawrence 70
Rome 63
Ho Chi Minh City 58
Nanjing 56
Brooklyn 47
Des Moines 47
Helsinki 46
São Paulo 40
North Bergen 37
Chicago 36
Munich 36
Princeton 35
Falkenstein 33
Figino 32
Tokyo 31
Dearborn 30
Jakarta 30
Washington 30
Buffalo 29
Columbus 29
Hanoi 28
Brussels 27
Inglewood 27
Phoenix 26
Dublin 24
London 24
San Diego 21
Nanchang 20
Abidjan 19
Atlanta 19
Boston 19
Moscow 19
Frankfurt am Main 18
San Francisco 18
Marseille 17
Montreal 17
Paris 17
Shenyang 17
Hebei 16
Jiaxing 16
Nuremberg 16
Rio de Janeiro 16
Baghdad 15
Johannesburg 15
Shanghai 15
Denver 14
Leawood 14
Miami 14
Turin 14
Warsaw 14
Guangzhou 13
Kansas City 13
Orem 13
Ardabil 12
Florence 12
Poplar 12
Stockholm 12
Tashkent 12
Augusta 11
Quito 11
The Dalles 11
Chennai 10
Jeddah 10
New Delhi 10
Toronto 10
West Jordan 10
Amsterdam 9
Belo Horizonte 9
Da Nang 9
Delhi 9
Genoa 9
Philadelphia 9
San Mateo 9
Vienna 9
Amman 8
Totale 7.055
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Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 259
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 226
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 217
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 212
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 203
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 202
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 200
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 199
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 198
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 194
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 192
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 188
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 188
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 187
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 178
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 177
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 172
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 170
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 169
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 168
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 154
Protein crystallography and fragment-based drug design 153
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 152
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 150
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 147
Organofluorine-containing therapeutics for treatment of cardiovascular disease 145
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 139
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 138
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 137
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 133
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 132
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 130
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 128
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 127
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 127
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 127
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 125
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 124
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 123
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 123
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 123
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 119
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 118
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 115
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 114
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 114
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 112
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 112
Antiplatelet activity of nipecotic acid derivatives 111
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 109
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 108
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 107
Novel factor Xa inhibitors: a patent review 107
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 106
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 102
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 101
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 97
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 96
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 96
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 96
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 95
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 94
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 93
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 92
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 90
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 89
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 88
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 88
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 85
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 84
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 82
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 80
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 80
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 78
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 78
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 78
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 76
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 76
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 75
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 73
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 73
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 71
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 71
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 67
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 65
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 64
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 63
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 60
null 60
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 55
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 54
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 51
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 51
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 51
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 50
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 48
A second life for MAO inhibitors: from CNS diseases to cancer 47
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 41
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 40
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 32
Totale 11.564
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Categoria #
all - tutte 46.912
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.912
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022470 0 0 0 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/20251.751 58 35 126 83 58 147 217 155 114 69 267 422
2025/20264.111 517 184 306 461 405 261 452 146 407 352 164 456
2026/2027971 121 204 340 306 0 0 0 0 0 0 0 0
Totale 11.688