IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 3.475
EU - Europa 1.269
AS - Asia 698
SA - Sud America 138
AF - Africa 19
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 1
Totale 5.602
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Nazione #
US - Stati Uniti d'America 3.469
CN - Cina 356
SE - Svezia 273
RU - Federazione Russa 263
IT - Italia 203
DE - Germania 194
SG - Singapore 181
BR - Brasile 129
FI - Finlandia 72
UA - Ucraina 65
GB - Regno Unito 54
FR - Francia 39
IN - India 38
IR - Iran 28
BE - Belgio 25
ID - Indonesia 24
IE - Irlanda 19
ES - Italia 17
HK - Hong Kong 14
NL - Olanda 13
AT - Austria 9
TR - Turchia 8
VN - Vietnam 8
KR - Corea 7
JP - Giappone 6
LT - Lituania 5
MA - Marocco 5
TW - Taiwan 5
CH - Svizzera 4
CZ - Repubblica Ceca 4
IL - Israele 4
IQ - Iraq 4
PK - Pakistan 4
EG - Egitto 3
UZ - Uzbekistan 3
AR - Argentina 2
AZ - Azerbaigian 2
CA - Canada 2
CL - Cile 2
DZ - Algeria 2
EE - Estonia 2
ET - Etiopia 2
EU - Europa 2
JO - Giordania 2
KE - Kenya 2
PL - Polonia 2
TN - Tunisia 2
AN - Antille olandesi 1
AU - Australia 1
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
CO - Colombia 1
DO - Repubblica Dominicana 1
EC - Ecuador 1
GA - Gabon 1
HN - Honduras 1
HU - Ungheria 1
IS - Islanda 1
NG - Nigeria 1
NI - Nicaragua 1
NP - Nepal 1
PE - Perù 1
PH - Filippine 1
PT - Portogallo 1
RO - Romania 1
UY - Uruguay 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 5.602
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Città #
Fairfield 448
Chandler 350
Woodbridge 326
Ashburn 257
Nyköping 220
Seattle 192
Houston 186
Cambridge 178
Ann Arbor 170
Wilmington 160
Jacksonville 151
Singapore 117
Bari 80
Roxbury 73
Lawrence 69
Beijing 61
Nanjing 56
Boardman 51
New York 50
Des Moines 47
North Bergen 35
Princeton 35
Brooklyn 32
Dearborn 30
Helsinki 27
Inglewood 27
Brussels 25
Jakarta 24
Nanchang 20
San Diego 20
Santa Clara 20
Dublin 19
Milan 19
Marseille 17
Moscow 17
Shenyang 17
Hebei 16
Jiaxing 16
Leawood 14
Shanghai 14
Ardabil 12
Los Angeles 12
Council Bluffs 11
Guangzhou 11
Hong Kong 11
London 11
Nuremberg 11
West Jordan 10
Munich 9
Paris 9
San Mateo 9
Augusta 8
Kansas City 8
Tehran 8
Tianjin 8
Dong Ket 7
Norwalk 7
Santa Marinella 7
Frankfurt am Main 6
Guwahati 6
Indiana 6
Jinhua 6
Kunming 6
San Francisco 6
Terlizzi 6
Washington 6
Wuhan 6
Düsseldorf 5
Falls Church 5
Jinan 5
Kolkata 5
Rio de Janeiro 5
São Paulo 5
Vienna 5
Wuxi 5
Amsterdam 4
Boydton 4
Brno 4
Carapicuíba 4
Changsha 4
Delhi 4
Napoli 4
Pune 4
Romola 4
Shenzhen 4
Weihai 4
Almere Stad 3
Azrou 3
Baghdad 3
Belo Horizonte 3
Bhubaneswar 3
Brasília 3
Chicago 3
Falkenstein 3
Grottaglie 3
Hefei 3
Hounslow 3
Izmir 3
La Canada Flintridge 3
New Delhi 3
Totale 4.035
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Nome #
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 149
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 148
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 136
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 133
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 133
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 131
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 129
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 125
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 120
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 118
Protein crystallography and fragment-based drug design 115
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 110
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 108
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 108
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 102
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 102
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 99
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 97
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 96
Organofluorine-containing therapeutics for treatment of cardiovascular disease 95
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 94
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 94
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 93
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 92
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 87
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 84
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 83
Novel factor Xa inhibitors: a patent review 81
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 81
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 79
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 79
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 79
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 78
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 71
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 69
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 69
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 69
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 68
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 68
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 65
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 63
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 63
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 63
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 61
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 61
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 60
null 60
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 60
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 58
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 57
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 57
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 56
Antiplatelet activity of nipecotic acid derivatives 56
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 56
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 53
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 53
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 52
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 50
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 48
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 46
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 44
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 43
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 42
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 39
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 39
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 39
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 37
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 37
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 36
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 36
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 32
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 29
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 28
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 25
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 25
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 25
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 24
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 24
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 21
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 21
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 20
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 18
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 17
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 17
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 15
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 15
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 14
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 13
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 13
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 12
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 12
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 11
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 9
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 9
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 8
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 8
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 1
Totale 5.928
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Categoria #
all - tutte 27.726
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.726
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020131 0 0 0 0 0 0 0 0 0 0 99 32
2020/2021850 88 83 60 78 80 34 64 54 83 91 92 43
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/20251.073 58 35 126 83 58 147 217 155 114 69 11 0
Totale 5.928