IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 3.399
EU - Europa 942
AS - Asia 567
SA - Sud America 8
AF - Africa 7
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 1
Totale 4.926
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Nazione #
US - Stati Uniti d'America 3.397
CN - Cina 341
SE - Svezia 273
IT - Italia 190
DE - Germania 167
SG - Singapore 125
UA - Ucraina 63
FI - Finlandia 57
GB - Regno Unito 49
IN - India 36
FR - Francia 35
IR - Iran 26
BE - Belgio 25
IE - Irlanda 19
ES - Italia 17
RU - Federazione Russa 17
NL - Olanda 11
VN - Vietnam 8
KR - Corea 7
TR - Turchia 6
JP - Giappone 5
TW - Taiwan 5
BR - Brasile 4
CH - Svizzera 4
CZ - Repubblica Ceca 4
EG - Egitto 3
LT - Lituania 3
MA - Marocco 3
EU - Europa 2
HK - Hong Kong 2
IL - Israele 2
IQ - Iraq 2
PL - Polonia 2
AN - Antille olandesi 1
AR - Argentina 1
AT - Austria 1
AU - Australia 1
BG - Bulgaria 1
CA - Canada 1
CL - Cile 1
EC - Ecuador 1
HU - Ungheria 1
IS - Islanda 1
NG - Nigeria 1
NP - Nepal 1
PE - Perù 1
PH - Filippine 1
PT - Portogallo 1
RO - Romania 1
Totale 4.926
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Città #
Fairfield 448
Chandler 350
Woodbridge 326
Ashburn 253
Nyköping 220
Seattle 192
Houston 186
Cambridge 178
Ann Arbor 170
Wilmington 160
Jacksonville 151
Singapore 104
Bari 75
Roxbury 73
Lawrence 69
Beijing 61
Nanjing 56
Boardman 51
New York 50
Des Moines 47
Princeton 35
Brooklyn 32
Dearborn 30
Inglewood 27
Brussels 25
Nanchang 20
San Diego 20
Santa Clara 20
Dublin 19
Milan 19
Marseille 17
Shenyang 17
Hebei 16
Jiaxing 16
Leawood 14
Ardabil 12
Helsinki 12
Shanghai 12
Guangzhou 11
Los Angeles 11
West Jordan 10
London 9
Munich 9
Paris 9
San Mateo 9
Augusta 8
Kansas City 8
Tianjin 8
Dong Ket 7
Norwalk 7
Santa Marinella 7
Indiana 6
Jinhua 6
San Francisco 6
Tehran 6
Terlizzi 6
Washington 6
Wuhan 6
Falls Church 5
Jinan 5
Kolkata 5
Kunming 5
Moscow 5
Wuxi 5
Boydton 4
Brno 4
Changsha 4
Delhi 4
Guwahati 4
Napoli 4
Pune 4
Romola 4
Shenzhen 4
Weihai 4
Almere Stad 3
Amsterdam 3
Azrou 3
Bhubaneswar 3
Chicago 3
Hefei 3
Hounslow 3
Izmir 3
La Canada Flintridge 3
New Delhi 3
Ningbo 3
Osaka 3
Philadelphia 3
Redwood City 3
Taizhou 3
Visakhapatnam 3
Zhengzhou 3
Baghdad 2
Camerino 2
Chengdu 2
Daejeon 2
Dalian 2
Delft 2
Florence 2
Frankfurt am Main 2
Fuzhou 2
Totale 3.877
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Nome #
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 139
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 132
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 129
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 127
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 123
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 122
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 120
Protein crystallography and fragment-based drug design 113
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 113
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 111
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 106
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 106
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 104
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 98
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 95
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 93
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 92
Organofluorine-containing therapeutics for treatment of cardiovascular disease 91
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 90
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 90
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 88
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 84
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 82
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 75
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 74
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 74
Novel factor Xa inhibitors: a patent review 73
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 72
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 72
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 69
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 68
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 67
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 67
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 67
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 62
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 61
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 61
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 60
null 60
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 59
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 59
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 58
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 57
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 56
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 56
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 55
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 54
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 54
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 52
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 52
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 51
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 51
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 51
Antiplatelet activity of nipecotic acid derivatives 50
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 49
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 48
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 48
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 46
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 45
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 42
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 40
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 37
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 36
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 33
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 33
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 32
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 29
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 28
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 26
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 24
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 23
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 23
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 23
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 22
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 20
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 18
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 14
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 13
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 12
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 11
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 11
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 9
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 8
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 7
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 7
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 6
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 6
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 5
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 5
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 5
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 4
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 3
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 2
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 2
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 1
Totale 5.201
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Categoria #
all - tutte 23.536
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 23.536
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020739 0 0 0 0 101 98 119 96 120 74 99 32
2020/2021850 88 83 60 78 80 34 64 54 83 91 92 43
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/2025346 58 35 126 83 44 0 0 0 0 0 0 0
Totale 5.201