IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 5.141
AS - Asia 2.458
EU - Europa 2.144
SA - Sud America 617
AF - Africa 102
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 10.471
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Nazione #
US - Stati Uniti d'America 5.044
SG - Singapore 870
IT - Italia 667
CN - Cina 585
BR - Brasile 485
HK - Hong Kong 301
SE - Svezia 285
RU - Federazione Russa 280
DE - Germania 276
VN - Vietnam 181
FR - Francia 153
GB - Regno Unito 111
IN - India 108
FI - Finlandia 97
BD - Bangladesh 81
UA - Ucraina 74
ID - Indonesia 51
AR - Argentina 41
CA - Canada 40
JP - Giappone 37
ES - Italia 34
IQ - Iraq 30
BE - Belgio 28
IR - Iran 28
TR - Turchia 28
MX - Messico 27
EC - Ecuador 25
NL - Olanda 24
ZA - Sudafrica 24
IE - Irlanda 23
PL - Polonia 23
CO - Colombia 21
CI - Costa d'Avorio 19
SA - Arabia Saudita 18
VE - Venezuela 17
AT - Austria 15
MA - Marocco 15
PH - Filippine 15
PK - Pakistan 14
KR - Corea 13
UZ - Uzbekistan 13
EG - Egitto 11
AE - Emirati Arabi Uniti 9
CL - Cile 9
JO - Giordania 9
CZ - Repubblica Ceca 8
DZ - Algeria 8
LT - Lituania 8
MY - Malesia 8
PE - Perù 8
TN - Tunisia 8
AZ - Azerbaigian 7
KZ - Kazakistan 7
NP - Nepal 7
IL - Israele 6
KE - Kenya 6
TW - Taiwan 6
AU - Australia 5
CH - Svizzera 5
PA - Panama 5
TH - Thailandia 5
BY - Bielorussia 4
CR - Costa Rica 4
EE - Estonia 4
ET - Etiopia 4
JM - Giamaica 4
PY - Paraguay 4
BO - Bolivia 3
HN - Honduras 3
KG - Kirghizistan 3
LB - Libano 3
NI - Nicaragua 3
PT - Portogallo 3
RO - Romania 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
BG - Bulgaria 2
BH - Bahrain 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EU - Europa 2
GR - Grecia 2
MD - Moldavia 2
MN - Mongolia 2
OM - Oman 2
PS - Palestinian Territory 2
RS - Serbia 2
SN - Senegal 2
XK - ???statistics.table.value.countryCode.XK??? 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AL - Albania 1
AN - Antille olandesi 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BN - Brunei Darussalam 1
BW - Botswana 1
GA - Gabon 1
Totale 10.456
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Città #
Ashburn 538
Fairfield 448
Singapore 438
Chandler 350
Woodbridge 326
San Jose 300
Hong Kong 284
Milan 248
Nyköping 220
Seattle 201
Houston 196
Cambridge 178
Ann Arbor 170
Wilmington 164
Beijing 163
Jacksonville 152
Dallas 116
New York 90
Bari 86
Boardman 80
Council Bluffs 74
Roxbury 73
Lauterbourg 72
Lawrence 69
Los Angeles 61
Rome 60
Ho Chi Minh City 57
Nanjing 56
Santa Clara 51
Brooklyn 47
Des Moines 47
Helsinki 46
São Paulo 38
Munich 36
North Bergen 35
Princeton 35
Falkenstein 33
Figino 32
Dearborn 30
Jakarta 30
Tokyo 30
Chicago 28
Hanoi 28
Brussels 27
Columbus 27
Inglewood 27
Buffalo 25
London 24
Dublin 22
Nanchang 20
San Diego 20
Abidjan 19
Moscow 19
Frankfurt am Main 18
San Francisco 18
Marseille 17
Paris 17
Shenyang 17
Atlanta 16
Hebei 16
Jiaxing 16
Montreal 16
Nuremberg 16
Rio de Janeiro 16
Baghdad 15
Boston 15
Johannesburg 15
Shanghai 15
Leawood 14
Warsaw 14
Denver 13
Guangzhou 13
Phoenix 13
Turin 13
Ardabil 12
Florence 12
Orem 12
Poplar 12
Stockholm 12
Tashkent 12
Augusta 11
The Dalles 11
Chennai 10
Jeddah 10
Kansas City 10
New Delhi 10
West Jordan 10
Amsterdam 9
Belo Horizonte 9
Da Nang 9
Delhi 9
Genoa 9
Quito 9
San Mateo 9
Vienna 9
Amman 8
Brasília 8
Dhaka 8
Haiphong 8
Mexico City 8
Totale 6.625
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Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 228
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 216
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 201
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 193
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 190
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 190
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 189
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 185
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 183
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 183
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 181
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 179
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 177
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 166
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 165
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 162
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 158
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 153
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 150
Protein crystallography and fragment-based drug design 147
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 143
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 142
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 139
Organofluorine-containing therapeutics for treatment of cardiovascular disease 136
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 132
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 130
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 127
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 126
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 124
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 123
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 120
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 117
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 115
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 114
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 114
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 113
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 112
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 111
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 110
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 107
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 107
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 105
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 103
Novel factor Xa inhibitors: a patent review 103
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 102
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 102
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 102
Antiplatelet activity of nipecotic acid derivatives 100
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 100
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 99
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 99
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 94
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 92
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 90
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 90
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 88
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 88
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 88
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 87
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 86
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 85
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 84
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 82
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 82
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 82
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 81
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 77
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 74
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 73
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 73
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 72
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 69
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 69
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 67
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 66
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 65
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 65
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 65
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 64
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 63
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 60
null 60
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 58
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 51
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 51
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 49
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 49
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 48
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 44
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 42
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 40
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 35
A second life for MAO inhibitors: from CNS diseases to cancer 34
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 30
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 26
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 24
Totale 10.747
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Categoria #
all - tutte 43.500
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 43.500
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/20251.751 58 35 126 83 58 147 217 155 114 69 267 422
2025/20264.111 517 184 306 461 405 261 452 146 407 352 164 456
2026/2027102 102 0 0 0 0 0 0 0 0 0 0 0
Totale 10.819