IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
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Continente #
NA - Nord America 4.857
AS - Asia 2.414
EU - Europa 1.759
SA - Sud America 613
AF - Africa 102
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 9.754
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Nazione #
US - Stati Uniti d'America 4.777
SG - Singapore 870
CN - Cina 570
BR - Brasile 483
HK - Hong Kong 297
IT - Italia 289
SE - Svezia 285
RU - Federazione Russa 280
DE - Germania 276
VN - Vietnam 182
FR - Francia 153
GB - Regno Unito 112
IN - India 105
FI - Finlandia 97
UA - Ucraina 74
BD - Bangladesh 66
ID - Indonesia 50
AR - Argentina 40
JP - Giappone 37
ES - Italia 34
CA - Canada 33
IQ - Iraq 30
TR - Turchia 29
BE - Belgio 28
IR - Iran 28
MX - Messico 27
EC - Ecuador 24
NL - Olanda 24
ZA - Sudafrica 24
IE - Irlanda 22
CO - Colombia 21
PL - Polonia 21
CI - Costa d'Avorio 19
SA - Arabia Saudita 17
VE - Venezuela 17
AT - Austria 15
MA - Marocco 15
PH - Filippine 15
PK - Pakistan 14
KR - Corea 13
UZ - Uzbekistan 13
EG - Egitto 11
AE - Emirati Arabi Uniti 9
CL - Cile 9
JO - Giordania 9
TN - Tunisia 9
DZ - Algeria 8
LT - Lituania 8
PE - Perù 8
CZ - Repubblica Ceca 7
MY - Malesia 7
NP - Nepal 7
AZ - Azerbaigian 6
IL - Israele 6
KE - Kenya 6
KZ - Kazakistan 6
TW - Taiwan 6
AU - Australia 5
CH - Svizzera 5
PA - Panama 5
BY - Bielorussia 4
ET - Etiopia 4
PY - Paraguay 4
BO - Bolivia 3
EE - Estonia 3
KG - Kirghizistan 3
LB - Libano 3
NI - Nicaragua 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
BG - Bulgaria 2
BH - Bahrain 2
DK - Danimarca 2
DO - Repubblica Dominicana 2
EU - Europa 2
HN - Honduras 2
JM - Giamaica 2
MD - Moldavia 2
MN - Mongolia 2
OM - Oman 2
PS - Palestinian Territory 2
PT - Portogallo 2
RO - Romania 2
RS - Serbia 2
SN - Senegal 2
TH - Thailandia 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AN - Antille olandesi 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
GA - Gabon 1
GD - Grenada 1
GE - Georgia 1
GR - Grecia 1
HU - Ungheria 1
IS - Islanda 1
Totale 9.745
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Città #
Ashburn 517
Fairfield 448
Singapore 439
Chandler 350
Woodbridge 326
Hong Kong 280
San Jose 238
Nyköping 220
Seattle 200
Houston 193
Cambridge 178
Ann Arbor 170
Wilmington 163
Beijing 157
Jacksonville 152
Dallas 112
Bari 85
New York 81
Council Bluffs 73
Roxbury 73
Lauterbourg 72
Lawrence 69
Ho Chi Minh City 57
Los Angeles 56
Nanjing 56
Boardman 54
Brooklyn 48
Des Moines 47
Helsinki 46
Santa Clara 40
São Paulo 38
Munich 36
North Bergen 35
Princeton 35
Falkenstein 33
Dearborn 30
Jakarta 30
Tokyo 30
Hanoi 28
Brussels 27
Inglewood 27
Chicago 26
London 24
Milan 24
Buffalo 22
Dublin 21
Nanchang 20
San Diego 20
Abidjan 19
Moscow 19
Frankfurt am Main 18
San Francisco 18
Marseille 17
Paris 17
Shenyang 17
Hebei 16
Jiaxing 16
Nuremberg 16
Rio de Janeiro 16
Atlanta 15
Baghdad 15
Boston 15
Johannesburg 15
Montreal 15
Shanghai 15
Leawood 14
Warsaw 14
Denver 13
Guangzhou 13
Ardabil 12
Phoenix 12
Poplar 12
Stockholm 12
Tashkent 12
Augusta 11
Chennai 11
The Dalles 11
Columbus 10
Jeddah 10
Orem 10
West Jordan 10
Amsterdam 9
Belo Horizonte 9
Da Nang 9
Delhi 9
Kansas City 9
New Delhi 9
San Mateo 9
Vienna 9
Amman 8
Brasília 8
Dhaka 8
Haiphong 8
Manchester 8
Porto Alegre 8
Quito 8
Tehran 8
Tianjin 8
Buenos Aires 7
Caracas 7
Totale 6.130
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Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 216
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 202
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 198
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 188
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 185
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 180
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 180
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 174
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 171
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 169
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 168
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 167
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 165
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 162
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 160
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 158
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 158
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 148
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 146
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 146
Protein crystallography and fragment-based drug design 144
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 139
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 132
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 129
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 128
Organofluorine-containing therapeutics for treatment of cardiovascular disease 126
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 126
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 123
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 120
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 116
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 114
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 113
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 113
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 107
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 107
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 106
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 105
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 104
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 101
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 101
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 100
Novel factor Xa inhibitors: a patent review 99
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 99
Antiplatelet activity of nipecotic acid derivatives 98
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 98
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 98
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 96
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 96
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 96
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 93
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 92
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 91
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 90
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 89
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 88
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 88
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 85
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 85
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 82
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 80
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 79
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 79
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 79
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 77
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 77
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 75
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 75
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 75
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 71
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 70
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 68
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 66
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 66
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 62
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 61
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 61
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 60
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 60
null 60
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 59
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 59
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 58
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 57
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 55
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 50
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 48
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 48
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 47
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 42
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 42
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 40
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 38
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 31
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 28
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 25
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 24
A second life for MAO inhibitors: from CNS diseases to cancer 23
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 20
Totale 10.023
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Categoria #
all - tutte 40.232
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 40.232
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021226 0 0 0 0 0 0 0 0 0 91 92 43
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/20251.751 58 35 126 83 58 147 217 155 114 69 267 422
2025/20263.484 517 184 306 462 419 265 453 148 410 320 0 0
Totale 10.090