IRIS
DE CANDIA, MODESTO
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 4.232
AS - Asia 1.903
EU - Europa 1.510
SA - Sud America 489
AF - Africa 69
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 2
Totale 8.209
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 4.183
SG - Singapore 702
CN - Cina 510
BR - Brasile 416
SE - Svezia 284
HK - Hong Kong 276
RU - Federazione Russa 271
DE - Germania 250
IT - Italia 225
VN - Vietnam 122
GB - Regno Unito 100
FI - Finlandia 78
IN - India 70
UA - Ucraina 69
FR - Francia 66
ID - Indonesia 40
AR - Argentina 31
ES - Italia 28
IR - Iran 28
BD - Bangladesh 27
BE - Belgio 27
JP - Giappone 23
CA - Canada 22
IE - Irlanda 21
NL - Olanda 20
CI - Costa d'Avorio 19
PL - Polonia 17
TR - Turchia 16
AT - Austria 15
MX - Messico 15
ZA - Sudafrica 13
IQ - Iraq 12
EC - Ecuador 11
KR - Corea 11
MA - Marocco 10
UZ - Uzbekistan 9
LT - Lituania 8
PK - Pakistan 8
CO - Colombia 7
CZ - Repubblica Ceca 7
VE - Venezuela 7
AE - Emirati Arabi Uniti 6
EG - Egitto 6
PE - Perù 6
SA - Arabia Saudita 6
IL - Israele 5
JO - Giordania 5
TN - Tunisia 5
TW - Taiwan 5
AZ - Azerbaigian 4
BY - Bielorussia 4
CH - Svizzera 4
CL - Cile 4
DZ - Algeria 4
KE - Kenya 4
EE - Estonia 3
ET - Etiopia 3
KZ - Kazakistan 3
NI - Nicaragua 3
NP - Nepal 3
PH - Filippine 3
AU - Australia 2
BG - Bulgaria 2
BO - Bolivia 2
DO - Repubblica Dominicana 2
EU - Europa 2
OM - Oman 2
PT - Portogallo 2
PY - Paraguay 2
SK - Slovacchia (Repubblica Slovacca) 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AL - Albania 1
AN - Antille olandesi 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BN - Brunei Darussalam 1
CR - Costa Rica 1
GA - Gabon 1
GD - Grenada 1
GR - Grecia 1
HN - Honduras 1
HU - Ungheria 1
IS - Islanda 1
JM - Giamaica 1
KG - Kirghizistan 1
MK - Macedonia 1
MW - Malawi 1
MY - Malesia 1
NG - Nigeria 1
PA - Panama 1
PS - Palestinian Territory 1
RO - Romania 1
SN - Senegal 1
SR - Suriname 1
TH - Thailandia 1
TJ - Tagikistan 1
TT - Trinidad e Tobago 1
Totale 8.209
Salva come PNG Salva come JPEG
Città #
Fairfield 448
Ashburn 437
Chandler 350
Woodbridge 326
Singapore 320
Hong Kong 264
Nyköping 220
Seattle 197
Houston 191
Cambridge 178
Ann Arbor 170
Wilmington 163
Jacksonville 151
Beijing 149
Dallas 106
Bari 84
New York 73
Roxbury 73
Lawrence 69
Nanjing 56
Boardman 51
Brooklyn 47
Des Moines 47
Los Angeles 45
Ho Chi Minh City 44
Munich 36
North Bergen 35
Princeton 35
Dearborn 30
Santa Clara 30
São Paulo 30
Jakarta 28
Helsinki 27
Inglewood 27
Brussels 26
Council Bluffs 23
Chicago 22
London 22
Milan 22
Buffalo 21
Dublin 21
Falkenstein 21
Hanoi 20
Nanchang 20
San Diego 20
Abidjan 19
Moscow 18
Tokyo 18
Marseille 17
Shenyang 17
Hebei 16
Jiaxing 16
Nuremberg 16
Shanghai 15
Leawood 14
San Francisco 14
Guangzhou 13
Rio de Janeiro 13
Warsaw 13
Ardabil 12
Boston 12
Montreal 12
Frankfurt am Main 11
Johannesburg 11
Stockholm 11
The Dalles 11
Atlanta 10
Augusta 10
Paris 10
West Jordan 10
Belo Horizonte 9
Chennai 9
Columbus 9
Kansas City 9
Poplar 9
San Mateo 9
Vienna 9
Amsterdam 8
Brasília 8
Denver 8
Phoenix 8
Tashkent 8
Tehran 8
Tianjin 8
Dong Ket 7
Florence 7
Manchester 7
Norwalk 7
Santa Marinella 7
Baghdad 6
Buenos Aires 6
Dhaka 6
Guwahati 6
Indiana 6
Jinhua 6
Kunming 6
New Delhi 6
Porto Alegre 6
Terlizzi 6
Washington 6
Totale 5.334
Salva come PNG Salva come JPEG
Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 190
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 178
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 177
Delivery of proapoptotic agents in glioma cell lines by TSPO ligand–dextran nanogels 171
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 162
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 160
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 160
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 159
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 154
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 153
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 150
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 146
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 143
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 143
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 143
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 139
Protein crystallography and fragment-based drug design 137
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 132
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 130
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 124
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 123
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 121
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 121
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 120
Targeting a Mirabegron precursor by BH3-mediated continuous flow reduction process 119
Organofluorine-containing therapeutics for treatment of cardiovascular disease 118
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 117
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 114
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 111
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 110
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 102
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 101
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 99
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 99
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 95
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 95
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 93
Novel factor Xa inhibitors: a patent review 92
Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa 90
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 89
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 88
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 87
Synthesis and Biological Evaluation of Direct Thrombin Inhibitors Bearing 4-(Piperidin-1-yl)pyridine at the P1 Position with Potent Anticoagulant Activity 86
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 84
Antiplatelet activity of nipecotic acid derivatives 82
beta-D-glucosyl conjugates of highly potent inhibitors of blood coagulation factor Xa bearing 2-chlorothiophene as a P1 motif 82
Investigation on pyrrolo[3,2-c]pyridine derivatives as inhibitors of platelet aggregation 80
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 79
How a β-D-Glucoside Side Chain Enhances Binding Affinity to Thrombin of Inhibitors Bearing 2-Chlorothiophene as P1 Moiety: Crystallography, Fragment Deconstruction Study and Evaluation of Antithrombotic Properties 78
PHYSICOCHEMICAL PROPERTIES AND ANTIMICROBIAL ACTIVITY OF NEW SPIROCYCLIC THIENO[2,3-d]PYRIMIDIN-4(3H)-ONE DERIVATIVES 77
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 77
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 75
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 75
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 75
Benzyloxyanilides of nipecotic acids with dual antithrombotic effects: inhibition of coagulative serine proteases and antiplatelet activity 74
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 74
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 71
Investigating Selective Inhibition of Thrombin and Factor Xa by Benzamidine-bearing Bis-malonamides through Molecular Modeling and 3D-QSAR 70
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 70
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 69
Pyridone-Hydroxypyridine Tautomerism as Encoded into Lipophilicity parameters of cardiotonic Milrinone Analogs 69
XXV Congresso Nazionale della Società Chimica Italiana - Atti del Congresso 65
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 65
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 64
Structure-based design of novel nipecotamide-containing direct thrombin inhibitors 64
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 63
Synthesis, biological activity and SARs of new heteroaryl-substituted isonipecotanilide inhibitors of the blood coagulation factors 61
Lead optimization studies, synthesis and biological evaluation of new isonipecotamide-based orally active thrombin inhibitors 61
null 60
New, low molecular weight, antithrombotic agents with dual function: inhibition of factor Xa and platelet aggregation 59
The exploration of 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole derivatives as selective butyrylcholinesterase inhibitors 59
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 59
Insights into structure–activity relationships from lipophilicity profiles of pyridin-2(1H)-one analogs of the cardiotonic agent milrinon 58
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 56
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 55
Fragment deconstruction study and human thrombin-bound crystal structures of new β-d-glucose-containing anticoagulants 54
The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain. 54
Piperidine carboxylic acid derivatives as inhibitors of platelet aggregation 53
Probing new inhibitors of platelet aggregation showing additional antithrombotic activities 53
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 48
Hansch-Type QSAR Models for the Rational Design of MAO Inhibitors: Basic Principles and Methodology 46
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 45
Synthesis, computational and experimental pharmacological studies for (thio)ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and chalcogen-dependent intrinsic activity in search for new class of drugs against Alzheimer's disease 44
Recyclization of benzofuropyridines by the action of acticated alkynes in the synthesis of spiro[benzofuropyrididines], representative of a new class of acetylcholinesterase inhibitors 44
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 41
Exploring Mannosylpurines as Copper Chelators and Cholinesterase Inhibitors with Potential for Alzheimer’s Disease 39
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 39
New azepino[4,3-b]indole derivatives, as selective butyrylcholinesterase inhibitors with potential for neurodegenerative disorders 37
Interplay between Ionization and Tautomerism in Bioactive β-Enamino Ester-Containing Cyclic Compounds: Study of Annulated 1,2,3,6-Tetrahydroazocine Derivatives 36
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 35
Targeting of the translocator protein 18 kDa (TSPO): A valuable approach for nuclear and optical imaging of activated microglia. 35
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 30
Novel Dual-Acting Hybrids Targeting Type-2 Cannabinoid Receptors and Cholinesterase Activity Show Neuroprotective Effects In Vitro and Amelioration of Cognitive Impairment In Vivo 29
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 23
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 22
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 20
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 18
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 16
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 8
A second life for MAO inhibitors: from CNS diseases to cancer 7
Totale 8.527
Salva come PNG Salva come JPEG
Categoria #
all - tutte 37.215
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.215
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021461 0 0 0 0 0 34 64 54 83 91 92 43
2021/2022614 35 74 35 9 17 42 38 27 42 51 99 145
2022/20231.027 151 115 53 79 143 99 13 132 165 26 29 22
2023/2024509 34 58 31 50 36 94 32 19 22 22 19 92
2024/20251.751 58 35 126 83 58 147 217 155 114 69 267 422
2025/20261.938 517 184 306 462 419 50 0 0 0 0 0 0
Totale 8.544