IRIS
LAGHEZZA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 8.951
AS - Asia 3.627
EU - Europa 2.662
SA - Sud America 1.065
AF - Africa 113
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 4
Totale 16.435
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Nazione #
US - Stati Uniti d'America 8.837
SG - Singapore 1.481
CN - Cina 961
BR - Brasile 917
HK - Hong Kong 538
SE - Svezia 441
IT - Italia 421
RU - Federazione Russa 420
DE - Germania 299
VN - Vietnam 265
UA - Ucraina 262
GB - Regno Unito 219
FI - Finlandia 189
FR - Francia 164
IN - India 100
AR - Argentina 60
CA - Canada 56
ID - Indonesia 55
BE - Belgio 46
CI - Costa d'Avorio 44
AT - Austria 43
BD - Bangladesh 42
MX - Messico 33
EC - Ecuador 28
IE - Irlanda 28
PL - Polonia 27
JP - Giappone 24
ZA - Sudafrica 23
IQ - Iraq 22
TR - Turchia 19
ES - Italia 18
CH - Svizzera 17
NL - Olanda 16
CO - Colombia 14
VE - Venezuela 14
IR - Iran 13
AU - Australia 11
EG - Egitto 11
KR - Corea 11
LT - Lituania 11
PT - Portogallo 11
SA - Arabia Saudita 11
PY - Paraguay 10
PE - Perù 9
CL - Cile 8
JO - Giordania 8
KE - Kenya 8
TW - Taiwan 8
IL - Israele 7
MA - Marocco 7
UZ - Uzbekistan 7
BH - Bahrain 6
CZ - Repubblica Ceca 6
PK - Pakistan 6
JM - Giamaica 5
AE - Emirati Arabi Uniti 4
DK - Danimarca 4
DZ - Algeria 4
EE - Estonia 4
LB - Libano 4
NP - Nepal 4
TT - Trinidad e Tobago 4
AZ - Azerbaigian 3
BB - Barbados 3
KZ - Kazakistan 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
TN - Tunisia 3
UY - Uruguay 3
A1 - Anonimo 2
AL - Albania 2
BG - Bulgaria 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
EU - Europa 2
GA - Gabon 2
GE - Georgia 2
HN - Honduras 2
KG - Kirghizistan 2
KH - Cambogia 2
KW - Kuwait 2
LV - Lettonia 2
OM - Oman 2
PA - Panama 2
PS - Palestinian Territory 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CG - Congo 1
CV - Capo Verde 1
GH - Ghana 1
GP - Guadalupe 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
LA - Repubblica Popolare Democratica del Laos 1
Totale 16.417
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Città #
Fairfield 916
Ashburn 892
Chandler 807
Woodbridge 692
Singapore 676
Jacksonville 596
Hong Kong 529
Houston 468
Cambridge 422
Seattle 372
Nyköping 347
Ann Arbor 307
Wilmington 302
Beijing 291
Lawrence 181
Roxbury 176
Dallas 172
Nanjing 146
New York 145
Bari 133
Princeton 131
Los Angeles 116
Boardman 108
Des Moines 102
Ho Chi Minh City 102
Inglewood 89
Munich 72
São Paulo 72
Brooklyn 54
Santa Clara 52
Hanoi 49
San Diego 47
Brussels 45
London 45
Abidjan 44
Council Bluffs 43
Jakarta 43
Chicago 39
Jiaxing 39
Moscow 39
Nanchang 39
Hebei 38
Buffalo 35
Helsinki 35
North Bergen 35
Shenyang 32
Changsha 31
Frankfurt am Main 30
Rio de Janeiro 30
Marseille 28
Naples 28
Dublin 27
Milan 26
Washington 26
Dong Ket 25
San Francisco 24
Guangzhou 23
Tokyo 23
Tianjin 22
Fragagnano 21
Belo Horizonte 20
Paris 20
Warsaw 20
Chennai 19
Atlanta 18
Johannesburg 18
Curitiba 17
Nuremberg 17
Denver 16
Florence 16
Poplar 16
Boydton 15
Campinas 15
Manchester 15
Montreal 15
Pune 15
Brasília 14
Dearborn 14
Langenzersdorf 14
Toronto 14
Vienna 14
Haiphong 13
Redondo Beach 13
Shanghai 13
Augusta 12
Boston 12
Phoenix 12
The Dalles 12
Turku 12
Wuhan 12
Wuxi 12
Columbus 11
Guayaquil 11
Leawood 11
Stockholm 11
Amsterdam 10
Da Nang 10
Falkenstein 10
Goiânia 10
Redwood City 10
Totale 11.038
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 212
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 189
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 189
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 189
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 171
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 169
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 166
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 165
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 161
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 155
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 150
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 144
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 143
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 141
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 140
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 139
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 136
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 134
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 134
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 133
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 132
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 132
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 130
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 129
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 129
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 128
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 127
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 126
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 125
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 123
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 123
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 121
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 121
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 121
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 120
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 119
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 118
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 118
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 117
Structural development studies of PPARs ligands based on tyrosine scaffold. 113
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 113
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 112
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 110
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 110
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 109
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 109
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 108
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 108
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 107
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 106
Single-nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes 105
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 105
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 105
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 104
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 103
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 103
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 102
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 99
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 98
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 97
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 97
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 96
Resveratrol and Its Metabolites Bind to PPARs 96
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 96
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 96
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 95
Mimic catechins to develop selective MMP-2 inhibitors 94
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 94
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 92
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 92
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 91
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 91
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 90
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 89
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 86
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 86
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 84
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 83
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 82
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 82
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 82
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 82
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 80
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 79
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 79
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 79
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 79
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 78
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 77
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 75
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 74
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 74
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 72
Probing the S1’ Site for the Identification of Non-Zinc- Binding MMP-2 Inhibitors 71
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 70
Antioxidant activity of uva di troia canosina ad acino piccolo: comparison of different extraction methods 70
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 70
Tissue specific action of the 2-(propyl)-1,4-benzoxazine on pancreatic beta cell ATP-sensitive potassium channels 70
Selective MMP inhibitors for the treatment of skeletal malignancy. 70
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies. 70
Totale 11.058
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Categoria #
all - tutte 75.487
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 75.487
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021955 0 0 0 0 0 28 135 83 142 290 162 115
2021/20221.259 52 174 18 33 44 63 54 55 72 67 229 398
2022/20232.130 358 175 128 180 276 288 21 232 357 19 54 42
2023/2024900 63 127 53 59 94 229 51 48 22 33 34 87
2024/20253.261 153 71 288 151 86 203 316 311 154 192 396 940
2025/20263.642 913 429 509 957 733 101 0 0 0 0 0 0
Totale 17.063