IRIS
LAGHEZZA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 7.543
EU - Europa 1.906
AS - Asia 1.091
OC - Oceania 10
SA - Sud America 6
AF - Africa 4
Continente sconosciuto - Info sul continente non disponibili 4
Totale 10.564
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Nazione #
US - Stati Uniti d'America 7.529
CN - Cina 674
SE - Svezia 431
IT - Italia 329
SG - Singapore 307
UA - Ucraina 253
DE - Germania 200
FI - Finlandia 165
RU - Federazione Russa 145
GB - Regno Unito 136
FR - Francia 123
BE - Belgio 41
IN - India 39
IE - Irlanda 25
VN - Vietnam 25
CA - Canada 14
CH - Svizzera 14
IR - Iran 12
PT - Portogallo 10
AU - Australia 9
NL - Olanda 8
HK - Hong Kong 7
KR - Corea 7
CZ - Repubblica Ceca 5
LT - Lituania 5
AT - Austria 4
PL - Polonia 4
EG - Egitto 3
ES - Italia 3
JP - Giappone 3
TH - Thailandia 3
A1 - Anonimo 2
AR - Argentina 2
BR - Brasile 2
CL - Cile 2
EU - Europa 2
ID - Indonesia 2
IL - Israele 2
SY - Repubblica araba siriana 2
TR - Turchia 2
TW - Taiwan 2
BD - Bangladesh 1
BG - Bulgaria 1
DK - Danimarca 1
EE - Estonia 1
KH - Cambogia 1
KZ - Kazakistan 1
LV - Lettonia 1
MT - Malta 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PS - Palestinian Territory 1
Totale 10.564
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Città #
Fairfield 916
Chandler 807
Woodbridge 691
Jacksonville 595
Ashburn 569
Houston 456
Cambridge 422
Seattle 367
Nyköping 347
Ann Arbor 307
Wilmington 301
Singapore 226
Lawrence 181
Roxbury 176
Nanjing 146
Princeton 131
Bari 121
Beijing 114
Boardman 108
Des Moines 102
New York 102
Inglewood 89
San Diego 47
Brussels 41
Jiaxing 39
Nanchang 39
Hebei 38
Santa Clara 33
Shenyang 32
Brooklyn 31
Los Angeles 31
London 30
Changsha 28
Marseille 28
Dong Ket 25
Dublin 25
Washington 25
Helsinki 23
Milan 23
Guangzhou 22
Munich 22
Tianjin 21
Paris 20
Naples 15
Boydton 14
Dearborn 14
Frankfurt am Main 14
Augusta 12
Shanghai 12
Wuhan 12
Wuxi 12
Leawood 11
Pune 11
Redwood City 10
San Francisco 10
Toronto 10
Lisbon 9
Haikou 8
Shenzhen 8
Ardabil 7
Bitonto 7
Lausanne 7
Patna 7
Hounslow 6
Jinan 6
Kilburn 6
Norwalk 6
Salerno 6
San Mateo 6
Zhengzhou 6
Brindisi 5
Brno 5
Chiswick 5
Jinhua 5
Edinburgh 4
Hong Kong 4
Islington 4
Kansas City 4
Melbourne 4
Monmouth Junction 4
Napoli 4
Quanzhou 4
Taizhou 4
Warsaw 4
West Jordan 4
Zurich 4
Amsterdam 3
Auburn Hills 3
Brahmapur 3
Caserta 3
Cleveland 3
Falls Church 3
Florence 3
Hefei 3
Heze 3
Indiana 3
Kolkata 3
Nürnberg 3
Ottawa 3
Sannicandro di Bari 3
Totale 8.259
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 160
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 140
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 135
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 132
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 129
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 129
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 126
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 125
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 121
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 121
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 119
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 119
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 115
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 113
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 109
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 102
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 101
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 101
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 101
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 101
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 100
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 99
Structural development studies of PPARs ligands based on tyrosine scaffold. 99
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 96
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 96
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 95
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 94
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 94
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 93
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 92
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 89
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 89
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 89
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 89
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 88
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 87
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 85
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 83
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 83
Resveratrol and Its Metabolites Bind to PPARs 82
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 81
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 80
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 79
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 79
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 79
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 76
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 75
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 74
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 74
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 74
Single-nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes 73
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 71
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 70
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 69
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 68
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 68
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 67
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 67
Mimic catechins to develop selective MMP-2 inhibitors 66
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 66
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 65
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 65
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 64
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 64
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 62
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 61
Antioxidant activity of uva di troia canosina ad acino piccolo: comparison of different extraction methods 59
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 58
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 56
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 56
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 56
null 56
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 55
Probing the S1’ Site for the Identification of Non-Zinc- Binding MMP-2 Inhibitors 55
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 55
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 53
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 53
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 53
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 53
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 52
New chiral clofibric acid analogues as ligands of Peroxisome Proliferator-Activated Receptor (PPAR) alpha and gamma 51
Tissue specific action of the 2-(propyl)-1,4-benzoxazine on pancreatic beta cell ATP-sensitive potassium channels 51
LT175 is a novel PPARα/β ligand with potent insulin-sensitizing effects and reduced adipogenic properties 50
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 50
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 49
Synthesis, SAR, and Biological Evaluation of alpha-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors 49
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 49
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 49
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 48
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 48
Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) 47
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 47
Synthesis and biological evaluation of alpha sulfonyl phosphonic acids as new MMPs inhibitors 46
Sintesi di nuovi analoghi chirali dell’acido clofibrico e valutazione della loro attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alpha e gamma 46
Nuovi analoghi chirali dell’acido clofibrico ad attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alfa e gamma 45
Nuovi acidi bifenilsolfonil fosfonici: sintesi e inibizione selettiva di metalloproteinasi di matrice 45
null 45
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 45
Bone seeking MMP inhibitors for the treatment of prostate to bone metastases 44
BONE-SEEKING MMP INHIBITORS FOR THE TREATMENT OF MULTIPLE MYELOMA 44
Totale 7.776
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Categoria #
all - tutte 52.053
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 52.053
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.225 0 0 0 0 0 0 276 192 290 169 232 66
2020/20211.741 291 79 113 177 126 28 135 83 142 290 162 115
2021/20221.259 52 174 18 33 44 63 54 55 72 67 229 398
2022/20232.130 358 175 128 180 276 288 21 232 357 19 54 42
2023/2024900 63 127 53 59 94 229 51 48 22 33 34 87
2024/2025996 153 71 288 151 86 203 44 0 0 0 0 0
Totale 11.156