IRIS
LAGHEZZA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 9.969
AS - Asia 4.503
EU - Europa 3.144
SA - Sud America 1.274
AF - Africa 202
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 4
Totale 19.110
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Nazione #
US - Stati Uniti d'America 9.811
SG - Singapore 1.741
CN - Cina 1.096
BR - Brasile 1.017
HK - Hong Kong 576
IT - Italia 529
SE - Svezia 441
RU - Federazione Russa 428
FR - Francia 340
VN - Vietnam 332
DE - Germania 329
FI - Finlandia 265
UA - Ucraina 265
GB - Regno Unito 251
IN - India 186
BD - Bangladesh 89
AR - Argentina 88
CA - Canada 75
ID - Indonesia 67
IQ - Iraq 59
BE - Belgio 47
MX - Messico 47
CI - Costa d'Avorio 45
TR - Turchia 44
AT - Austria 43
ZA - Sudafrica 43
PL - Polonia 42
EC - Ecuador 40
JP - Giappone 37
CO - Colombia 34
IE - Irlanda 31
VE - Venezuela 31
PK - Pakistan 28
PH - Filippine 26
SA - Arabia Saudita 24
ES - Italia 23
NL - Olanda 23
EG - Egitto 20
CL - Cile 18
JO - Giordania 18
MA - Marocco 18
MY - Malesia 18
UZ - Uzbekistan 18
CH - Svizzera 17
KE - Kenya 17
KR - Corea 16
PY - Paraguay 16
TN - Tunisia 16
TW - Taiwan 16
LT - Lituania 15
IR - Iran 13
AU - Australia 12
IL - Israele 11
PE - Perù 11
PT - Portogallo 11
OM - Oman 10
AE - Emirati Arabi Uniti 9
LB - Libano 9
BH - Bahrain 8
BO - Bolivia 8
UY - Uruguay 8
AL - Albania 7
CZ - Repubblica Ceca 7
DZ - Algeria 7
JM - Giamaica 7
NP - Nepal 7
SN - Senegal 7
AZ - Azerbaigian 6
CR - Costa Rica 6
DK - Danimarca 5
ET - Etiopia 5
AO - Angola 4
EE - Estonia 4
GE - Georgia 4
KG - Kirghizistan 4
KW - Kuwait 4
PA - Panama 4
RS - Serbia 4
SY - Repubblica araba siriana 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
ZW - Zimbabwe 4
BB - Barbados 3
BG - Bulgaria 3
GA - Gabon 3
HU - Ungheria 3
KH - Cambogia 3
KZ - Kazakistan 3
LY - Libia 3
PS - Palestinian Territory 3
A1 - Anonimo 2
AM - Armenia 2
DO - Repubblica Dominicana 2
EU - Europa 2
GH - Ghana 2
GR - Grecia 2
GY - Guiana 2
HN - Honduras 2
LA - Repubblica Popolare Democratica del Laos 2
LV - Lettonia 2
Totale 19.078
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Città #
Ashburn 1.031
Fairfield 916
Singapore 861
Chandler 807
Woodbridge 692
Jacksonville 596
Hong Kong 558
San Jose 498
Houston 473
Cambridge 422
Seattle 372
Nyköping 347
Ann Arbor 307
Wilmington 302
Beijing 295
Lawrence 181
Dallas 177
Roxbury 176
Lauterbourg 173
New York 157
Nanjing 146
Bari 133
Princeton 131
Ho Chi Minh City 127
Los Angeles 127
Helsinki 111
Boardman 108
Des Moines 102
Council Bluffs 89
Inglewood 89
São Paulo 80
Munich 72
Santa Clara 71
Hanoi 65
Brooklyn 55
San Diego 47
Brussels 46
Jakarta 46
London 46
Abidjan 45
Chicago 45
Frankfurt am Main 45
Jiaxing 39
Moscow 39
Nanchang 39
Hebei 38
Buffalo 36
North Bergen 35
Tokyo 35
Naples 34
Rio de Janeiro 34
Shenyang 33
Changsha 31
Dublin 31
Warsaw 31
Chennai 30
Orem 30
Marseille 29
Milan 29
Baghdad 26
Denver 26
Johannesburg 26
San Francisco 26
Washington 26
Atlanta 25
Dong Ket 25
Guangzhou 24
Poplar 23
Manchester 22
Paris 22
Tianjin 22
Belo Horizonte 21
Fragagnano 21
Montreal 21
Toronto 20
Falkenstein 19
Curitiba 18
Nuremberg 18
Tashkent 18
Rome 17
Boston 16
Campinas 16
Florence 16
Phoenix 16
Amman 15
Boydton 15
Brasília 15
Guayaquil 15
Pune 15
Amsterdam 14
Cairo 14
Caracas 14
Dearborn 14
Haiphong 14
Langenzersdorf 14
Nairobi 14
Vienna 14
Augusta 13
Dhaka 13
Mexico City 13
Totale 12.496
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 223
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 218
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 204
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 203
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 191
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 181
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 180
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 180
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 180
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 178
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 167
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 164
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 164
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 157
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 153
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 152
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 152
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 151
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 151
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 151
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 148
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 147
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 146
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 146
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 144
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 144
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 144
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 143
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 142
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 140
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 140
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 137
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 137
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 136
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 136
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 134
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 133
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 133
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 130
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 130
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 128
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 127
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 125
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 124
Structural development studies of PPARs ligands based on tyrosine scaffold. 122
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 122
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 122
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 121
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 120
Single-nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes 119
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 119
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 119
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 118
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 118
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 118
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 118
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 117
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 117
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 117
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 114
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 113
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 111
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 110
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 110
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 110
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 109
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 109
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 109
Mimic catechins to develop selective MMP-2 inhibitors 108
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 107
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 106
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 105
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 104
Resveratrol and Its Metabolites Bind to PPARs 104
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 102
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 102
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 101
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 101
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 100
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 100
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 98
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 98
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 98
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 98
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 93
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 93
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 91
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 89
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease 89
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 88
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 87
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 87
Selective MMP inhibitors for the treatment of skeletal malignancy. 86
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 86
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies. 86
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease 85
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 85
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 84
LT175 is a novel PPARα/β ligand with potent insulin-sensitizing effects and reduced adipogenic properties 81
Nuovi acidi bifenilsolfonil fosfonici: sintesi e inibizione selettiva di metalloproteinasi di matrice 81
Totale 12.599
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Categoria #
all - tutte 80.939
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 80.939
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021567 0 0 0 0 0 0 0 0 0 290 162 115
2021/20221.259 52 174 18 33 44 63 54 55 72 67 229 398
2022/20232.130 358 175 128 180 276 288 21 232 357 19 54 42
2023/2024900 63 127 53 59 94 229 51 48 22 33 34 87
2024/20253.261 153 71 288 151 86 203 316 311 154 192 396 940
2025/20266.321 913 429 509 957 733 395 780 258 675 672 0 0
Totale 19.742