IRIS
LAGHEZZA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 9.034
AS - Asia 3.742
EU - Europa 2.683
SA - Sud America 1.078
AF - Africa 120
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 4
Totale 16.674
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Nazione #
US - Stati Uniti d'America 8.914
SG - Singapore 1.526
CN - Cina 973
BR - Brasile 928
HK - Hong Kong 544
SE - Svezia 441
IT - Italia 424
RU - Federazione Russa 420
DE - Germania 299
VN - Vietnam 295
UA - Ucraina 262
GB - Regno Unito 228
FI - Finlandia 189
FR - Francia 164
IN - India 107
AR - Argentina 60
CA - Canada 60
ID - Indonesia 55
BE - Belgio 46
BD - Bangladesh 45
CI - Costa d'Avorio 44
AT - Austria 43
MX - Messico 35
PL - Polonia 30
EC - Ecuador 28
IE - Irlanda 28
ZA - Sudafrica 28
IQ - Iraq 26
JP - Giappone 25
ES - Italia 20
TR - Turchia 19
CH - Svizzera 17
NL - Olanda 16
LT - Lituania 15
VE - Venezuela 15
CO - Colombia 14
IR - Iran 13
AU - Australia 11
EG - Egitto 11
KR - Corea 11
PT - Portogallo 11
SA - Arabia Saudita 11
JO - Giordania 10
PY - Paraguay 10
CL - Cile 9
PE - Perù 9
KE - Kenya 8
MA - Marocco 8
TW - Taiwan 8
IL - Israele 7
UZ - Uzbekistan 7
BH - Bahrain 6
CZ - Repubblica Ceca 6
PK - Pakistan 6
JM - Giamaica 5
LB - Libano 5
NP - Nepal 5
OM - Oman 5
AE - Emirati Arabi Uniti 4
DK - Danimarca 4
DZ - Algeria 4
EE - Estonia 4
TN - Tunisia 4
TT - Trinidad e Tobago 4
AZ - Azerbaigian 3
BB - Barbados 3
KZ - Kazakistan 3
RS - Serbia 3
SN - Senegal 3
SY - Repubblica araba siriana 3
TH - Thailandia 3
UY - Uruguay 3
A1 - Anonimo 2
AL - Albania 2
BG - Bulgaria 2
CR - Costa Rica 2
DO - Repubblica Dominicana 2
EU - Europa 2
GA - Gabon 2
GE - Georgia 2
HN - Honduras 2
KG - Kirghizistan 2
KH - Cambogia 2
KW - Kuwait 2
LV - Lettonia 2
PA - Panama 2
PS - Palestinian Territory 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CG - Congo 1
CV - Capo Verde 1
GH - Ghana 1
GP - Guadalupe 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
LA - Repubblica Popolare Democratica del Laos 1
Totale 16.656
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Città #
Fairfield 916
Ashburn 905
Chandler 807
Singapore 720
Woodbridge 692
Jacksonville 596
Hong Kong 535
Houston 470
Cambridge 422
Seattle 372
Nyköping 347
Ann Arbor 307
Wilmington 302
Beijing 291
Lawrence 181
Roxbury 176
Dallas 173
New York 152
Nanjing 146
Bari 133
Princeton 131
Los Angeles 117
Ho Chi Minh City 113
Boardman 108
Des Moines 102
Inglewood 89
São Paulo 74
Munich 72
Hanoi 56
Santa Clara 55
Brooklyn 54
San Diego 47
Brussels 45
London 45
Abidjan 44
Council Bluffs 43
Jakarta 43
Chicago 39
Jiaxing 39
Moscow 39
Nanchang 39
Hebei 38
Buffalo 35
Helsinki 35
North Bergen 35
Shenyang 32
Changsha 31
Rio de Janeiro 31
Frankfurt am Main 30
Marseille 28
Naples 28
Dublin 27
Milan 27
Washington 26
Dong Ket 25
San Francisco 24
Tokyo 24
Chennai 23
Guangzhou 23
Poplar 23
Warsaw 23
Denver 22
Tianjin 22
Fragagnano 21
Johannesburg 21
San Jose 21
Belo Horizonte 20
Paris 20
Atlanta 18
Curitiba 17
Manchester 17
Montreal 17
Nuremberg 17
Florence 16
Toronto 16
Boydton 15
Campinas 15
Orem 15
Pune 15
Brasília 14
Dearborn 14
Langenzersdorf 14
Phoenix 14
Vienna 14
Haiphong 13
Redondo Beach 13
Shanghai 13
Augusta 12
Boston 12
Da Nang 12
The Dalles 12
Turku 12
Wuhan 12
Wuxi 12
Columbus 11
Guayaquil 11
Leawood 11
Stockholm 11
Amman 10
Amsterdam 10
Totale 11.187
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 214
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 192
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 191
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 190
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 172
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 170
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 170
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 167
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 162
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 157
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 151
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 145
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 145
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 144
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 141
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 140
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 138
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 136
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 136
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 136
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 135
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 134
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 132
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 131
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 131
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 130
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 128
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 128
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 127
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 125
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 125
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 123
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 122
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 122
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 121
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 121
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 120
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 120
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 120
Structural development studies of PPARs ligands based on tyrosine scaffold. 114
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 113
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 113
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 112
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 111
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 111
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 110
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 109
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 109
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 108
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 107
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 107
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 107
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 107
Single-nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes 106
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 104
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 104
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 102
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 102
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 101
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 99
Resveratrol and Its Metabolites Bind to PPARs 98
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 98
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 98
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 98
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 97
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 96
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 96
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 94
Mimic catechins to develop selective MMP-2 inhibitors 94
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 92
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 92
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 91
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 91
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 89
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 88
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 86
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 86
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 85
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 84
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 84
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 84
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 82
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 82
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 82
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 80
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 80
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 79
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 79
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 78
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 78
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 77
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 77
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 74
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 72
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 71
Selective MMP inhibitors for the treatment of skeletal malignancy. 71
Probing the S1’ Site for the Identification of Non-Zinc- Binding MMP-2 Inhibitors 71
IDENTIFICATION OF A NOVEL PPARRα/γ DUAL AGONIST SHOWING ANTIDIABETIC EFFECTS AND ABLE TO BIND TO CANONICAL AND ALLOSTERIC SITES OF ABLE TO BIND TO CANONICAL AND ALLOSTERIC SITES OF PPARγ 70
Antioxidant activity of uva di troia canosina ad acino piccolo: comparison of different extraction methods 70
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 70
Totale 11.212
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Categoria #
all - tutte 76.696
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.696
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021955 0 0 0 0 0 28 135 83 142 290 162 115
2021/20221.259 52 174 18 33 44 63 54 55 72 67 229 398
2022/20232.130 358 175 128 180 276 288 21 232 357 19 54 42
2023/2024900 63 127 53 59 94 229 51 48 22 33 34 87
2024/20253.261 153 71 288 151 86 203 316 311 154 192 396 940
2025/20263.881 913 429 509 957 733 340 0 0 0 0 0 0
Totale 17.302