IRIS
LAGHEZZA, ANTONIO
 Distribuzione geografica
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Continente #
NA - Nord America 10.465
AS - Asia 4.587
EU - Europa 4.011
SA - Sud America 1.280
AF - Africa 202
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 4
Totale 20.563
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Nazione #
US - Stati Uniti d'America 10.267
SG - Singapore 1.764
IT - Italia 1.380
CN - Cina 1.114
BR - Brasile 1.019
HK - Hong Kong 585
SE - Svezia 441
RU - Federazione Russa 428
FR - Francia 342
VN - Vietnam 332
DE - Germania 329
UA - Ucraina 266
FI - Finlandia 265
GB - Regno Unito 254
IN - India 192
BD - Bangladesh 113
CA - Canada 97
AR - Argentina 88
ID - Indonesia 67
IQ - Iraq 59
MX - Messico 52
BE - Belgio 47
CI - Costa d'Avorio 45
TR - Turchia 44
AT - Austria 43
ZA - Sudafrica 43
PL - Polonia 42
EC - Ecuador 41
JP - Giappone 39
CO - Colombia 36
IE - Irlanda 32
VE - Venezuela 32
PK - Pakistan 28
NL - Olanda 26
PH - Filippine 26
ES - Italia 24
SA - Arabia Saudita 24
EG - Egitto 20
CH - Svizzera 19
CL - Cile 18
JO - Giordania 18
MA - Marocco 18
MY - Malesia 18
UZ - Uzbekistan 18
KE - Kenya 17
KR - Corea 17
PY - Paraguay 16
TN - Tunisia 16
TW - Taiwan 16
LT - Lituania 15
IR - Iran 13
AU - Australia 12
CR - Costa Rica 11
IL - Israele 11
PE - Perù 11
PT - Portogallo 11
JM - Giamaica 10
OM - Oman 10
AE - Emirati Arabi Uniti 9
LB - Libano 9
AL - Albania 8
BH - Bahrain 8
BO - Bolivia 8
UY - Uruguay 8
CZ - Repubblica Ceca 7
DZ - Algeria 7
NP - Nepal 7
SN - Senegal 7
AZ - Azerbaigian 6
DK - Danimarca 5
ET - Etiopia 5
RS - Serbia 5
TH - Thailandia 5
AO - Angola 4
EE - Estonia 4
GE - Georgia 4
KG - Kirghizistan 4
KW - Kuwait 4
NI - Nicaragua 4
PA - Panama 4
SY - Repubblica araba siriana 4
TT - Trinidad e Tobago 4
ZW - Zimbabwe 4
BB - Barbados 3
BG - Bulgaria 3
GA - Gabon 3
HN - Honduras 3
HU - Ungheria 3
KH - Cambogia 3
KZ - Kazakistan 3
LY - Libia 3
PS - Palestinian Territory 3
SV - El Salvador 3
A1 - Anonimo 2
AM - Armenia 2
DO - Repubblica Dominicana 2
EU - Europa 2
GH - Ghana 2
GR - Grecia 2
GY - Guiana 2
Totale 20.529
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Città #
Ashburn 1.072
Fairfield 916
Singapore 871
Chandler 807
Woodbridge 693
San Jose 601
Jacksonville 598
Hong Kong 567
Milan 515
Houston 474
Cambridge 424
Seattle 372
Nyköping 347
Ann Arbor 307
Wilmington 303
Beijing 302
Lawrence 181
Dallas 180
Roxbury 176
Lauterbourg 173
New York 173
Nanjing 146
Bari 141
Rome 140
Los Angeles 132
Princeton 131
Ho Chi Minh City 127
Boardman 117
Helsinki 111
Santa Clara 106
Des Moines 102
Council Bluffs 91
Inglewood 89
São Paulo 80
Munich 72
Hanoi 65
Brooklyn 57
Naples 48
London 47
San Diego 47
Brussels 46
Chicago 46
Jakarta 46
Abidjan 45
Frankfurt am Main 45
Figino 44
Turin 42
Jiaxing 39
Moscow 39
Nanchang 39
Buffalo 38
Hebei 38
Tokyo 37
North Bergen 35
Rio de Janeiro 34
Shenyang 33
Changsha 31
Dublin 31
Orem 31
Warsaw 31
Chennai 30
Columbus 29
Marseille 29
Washington 29
Atlanta 28
San Francisco 27
Baghdad 26
Denver 26
Johannesburg 26
Dong Ket 25
Florence 25
Montreal 25
Guangzhou 24
Poplar 23
Manchester 22
Paris 22
Tianjin 22
Toronto 22
Belo Horizonte 21
Fragagnano 21
Falkenstein 19
Curitiba 18
Mexico City 18
Nuremberg 18
Phoenix 18
Tashkent 18
Boston 17
Boydton 17
Campinas 16
Amman 15
Brasília 15
Guayaquil 15
Pune 15
Shanghai 15
Amsterdam 14
Augusta 14
Cairo 14
Caracas 14
Dearborn 14
Haiphong 14
Totale 13.491
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 235
Comparison Between Different Flavored Olive Oil Production Techniques: Healthy Value and Process Efficiency 229
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 208
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 208
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 206
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 198
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 192
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 185
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 179
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 173
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 170
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 168
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 167
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 165
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 162
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 161
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 159
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 158
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 158
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors 156
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 156
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 154
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 154
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 154
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 153
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 153
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases 151
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 151
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 149
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 148
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 146
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer 145
Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 144
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth 143
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 140
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 139
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 139
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 138
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 135
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 134
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 133
Structural development studies of PPARs ligands based on tyrosine scaffold. 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 132
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 131
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 130
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 130
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 128
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 128
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 128
Single-nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes 128
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 128
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 126
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 124
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 123
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 123
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 122
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 122
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 122
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 121
Seeking for non-zinc-binding MMP-2 inhibitors: Synthesis, biological evaluation and molecular modelling studies 121
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 121
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 120
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 119
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 118
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 117
Mimic catechins to develop selective MMP-2 inhibitors 117
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 115
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 114
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 113
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis 112
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 109
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 109
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 108
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 108
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 107
Resveratrol and Its Metabolites Bind to PPARs 107
Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases 106
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 104
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 103
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 103
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 101
Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13 100
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 100
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 100
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 100
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 99
Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies. 99
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease 97
Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease 97
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 94
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 92
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 92
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 91
Nuovi acidi bifenilsolfonil fosfonici: sintesi e inibizione selettiva di metalloproteinasi di matrice 91
Selective MMP inhibitors for the treatment of skeletal malignancy. 91
Synthesis and biological evaluation of sulfonyl phosphonic acids as new MMPs inhibitors. 86
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 86
Totale 13.372
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Categoria #
all - tutte 88.281
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 88.281
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.259 52 174 18 33 44 63 54 55 72 67 229 398
2022/20232.130 358 175 128 180 276 288 21 232 357 19 54 42
2023/2024900 63 127 53 59 94 229 51 48 22 33 34 87
2024/20253.261 153 71 288 151 86 203 316 311 154 192 396 940
2025/20267.600 913 429 509 957 733 395 780 258 675 775 276 900
2026/2027190 190 0 0 0 0 0 0 0 0 0 0 0
Totale 21.211