LAGHEZZA, ANTONIO
LAGHEZZA, ANTONIO
DIPARTIMENTO DI FARMACIA-SCIENZE DEL FARMACO
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone
2021-01-01 Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Loiodice, F.; Tortorella, P.
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS
2013-01-01 Carrieri, Antonio; Marco, Giudici; Mariagiovanna, Parente; Mario De, Rosas; Piemontese, Luca; Fracchiolla, Giuseppe; Laghezza, Antonio; Tortorella, Paolo; Carbonara, Giuseppe Gerardo; Antonio, Lavecchia; Federica, Gilardi; Maurizio, Crestani; Fulvio, Loiodice
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease
2022-01-01 Czarnota-Łydka, Kinga; Satała, Grzegorz; Brunetti, Leonardo; Laghezza, Antonio; Piemontese, Luca; DE CANDIA, Modesto; Purgatorio, Rosa; Gumułka, Magdalena; Kucwaj-Brysz, Katarzyna; Carrieri, Antonio; Handzlik, Jadwiga
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties
2024-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity
2022-01-01 Sblano, S.; Cerchia, C.; Laghezza, A.; Piemontese, L.; Brunetti, L.; Leuci, R.; Gilardi, F.; Thomas, A.; Genovese, M.; Santi, A.; Tortorella, P.; Paoli, P.; Lavecchia, A.; Loiodice, F.
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION
2023-01-01 Cerchia, C.; Laghezza, A.; Genovese, M.; Leuci, R.; Pranzini, E.; Santi, A.; Brunetti, L.; Piemontese, L.; Tortorella, P.; Biswas, A.; Singh, R. P.; Tambe, S.; Ca, S.; Pattnaik, A. K.; Jayaprakash, V.; Paoli, P.; Loiodice, F.; Lavecchia, A.
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition
2023-01-01 Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo
2006-01-01 Rolland, J. F.; Tricarico, Domenico; Laghezza, Antonio; Loiodice, Fulvio; Tortorella, V; Conte, Diana
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE)
2022-01-01 Leuci, R.; Brunetti, L.; Laghezza, A.; Piemontese, L.; Carrieri, A.; Pisani, L.; Tortorella, P.; Catto, M.; Loiodice, F.
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders
2020-01-01 Leuci, Rosalba; Brunetti, Leonardo; Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio; Piemontese, Luca
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects
2021-01-01 Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A.
Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer
2015-01-01 Tauro, Marilena; Laghezza, Antonio; Tortorella, Paolo; Lynch, Conor C.
Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases
2014-01-01 Tauro, Marilena; Laghezza, Antonio; Tortorella, Paolo; Lynch, Conor C.
Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth
2017-01-01 Tauro, M; Laghezza, A; Tortorella, P; Lynch, Cc
Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors
2016-01-01 Tauro, M; Laghezza, Antonio; Tortorella, Paolo; Lynch, Cc
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica
2010-01-01 Piemontese, L; Parente, M; Fracchiolla, Giuseppe; Laghezza, Antonio; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, F.
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA.
2010-01-01 Piemontese, Luca; Mariagiovanna, Parente; Fracchiolla, Giuseppe; Laghezza, Antonio; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, Fulvio
AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis
2024-01-01 Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors
2016-01-01 Tortorella, Paolo; Laghezza, Antonio; Durante, Milena; Gomez Monterrey, Isabel; Bertamino, Alessia; Campiglia, Pietro; Loiodice, Fulvio; Daniele, Simona; Martini, Claudia; Agamennone, Mariangela
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators
2013-01-01 Piemontese, Luca; Laghezza, Antonio; Fracchiolla, Giuseppe; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, Fulvio
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| (2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone | 1-gen-2021 | Laghezza, A.; Piemontese, L.; Brunetti, L.; Caradonna, A.; Agamennone, M.; Loiodice, F.; Tortorella, P. | |
| (contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS | 1-gen-2013 | Carrieri, Antonio; Marco, Giudici; Mariagiovanna, Parente; Mario De, Rosas; Piemontese, Luca; Fracchiolla, Giuseppe; Laghezza, Antonio; Tortorella, Paolo; Carbonara, Giuseppe Gerardo; Antonio, Lavecchia; Federica, Gilardi; Maurizio, Crestani; Fulvio, Loiodice | |
| 1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease | 1-gen-2022 | Czarnota-Łydka, Kinga; Satała, Grzegorz; Brunetti, Leonardo; Laghezza, Antonio; Piemontese, Luca; DE CANDIA, Modesto; Purgatorio, Rosa; Gumułka, Magdalena; Kucwaj-Brysz, Katarzyna; Carrieri, Antonio; Handzlik, Jadwiga | |
| A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties | 1-gen-2024 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Montanari, Roberta; Capelli, Davide; Wackerlig, Judith; Simic, Stefan; Falbo, Emanuele; Pecora, Lucia; Leuci, Rosalba; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Singh, Ravi Pratap; Tambe, Suhas; Sudeep, C. A.; Pattnaik, Ashok Kumar; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity | 1-gen-2022 | Sblano, S.; Cerchia, C.; Laghezza, A.; Piemontese, L.; Brunetti, L.; Leuci, R.; Gilardi, F.; Thomas, A.; Genovese, M.; Santi, A.; Tortorella, P.; Paoli, P.; Lavecchia, A.; Loiodice, F. | |
| A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION | 1-gen-2023 | Cerchia, C.; Laghezza, A.; Genovese, M.; Leuci, R.; Pranzini, E.; Santi, A.; Brunetti, L.; Piemontese, L.; Tortorella, P.; Biswas, A.; Singh, R. P.; Tambe, S.; Ca, S.; Pattnaik, A. K.; Jayaprakash, V.; Paoli, P.; Loiodice, F.; Lavecchia, A. | |
| A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition | 1-gen-2023 | Laghezza, Antonio; Cerchia, Carmen; Genovese, Massimo; Leuci, Rosalba; Pranzini, Erica; Santi, Alice; Brunetti, Leonardo; Piemontese, Luca; Tortorella, Paolo; Biswas, Abanish; Pratap Singh, Ravi; Tambe, Suhas; Ca, Sudeep; Kumar Pattnaik, Ashok; Jayaprakash, Venkatesan; Paoli, Paolo; Lavecchia, Antonio; Loiodice, Fulvio | |
| A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo | 1-gen-2006 | Rolland, J. F.; Tricarico, Domenico; Laghezza, Antonio; Loiodice, Fulvio; Tortorella, V; Conte, Diana | |
| A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) | 1-gen-2022 | Leuci, R.; Brunetti, L.; Laghezza, A.; Piemontese, L.; Carrieri, A.; Pisani, L.; Tortorella, P.; Catto, M.; Loiodice, F. | |
| A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders | 1-gen-2020 | Leuci, Rosalba; Brunetti, Leonardo; Laghezza, Antonio; Tortorella, Paolo; Loiodice, Fulvio; Piemontese, Luca | |
| A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects | 1-gen-2021 | Yasmin, S.; Cerchia, C.; Badavath, V. N.; Laghezza, A.; Dal Piaz, F.; Mondal, S. K.; Atli, O.; Baysal, M.; Vadivelan, S.; Shankar, S.; Siddique, M. U. M.; Pattnaik, A. K.; Singh, R. P.; Loiodice, F.; Jayaprakash, V.; Lavecchia, A. | |
| Abstract 398: Specific skeletal targeting of MMP-2 inhibitors for the treatment of bone metastatic breast cancer | 1-gen-2015 | Tauro, Marilena; Laghezza, Antonio; Tortorella, Paolo; Lynch, Conor C. | |
| Abstract 4858: A novel strategy for the selective and tissue specific inhibition of MMPs in active breast cancer to bone metastases | 1-gen-2014 | Tauro, Marilena; Laghezza, Antonio; Tortorella, Paolo; Lynch, Conor C. | |
| Abstract P6-12-10: Bone seeking matrix metalloproteinase-2 inhibitors prevent bone metastatic breast cancer growth | 1-gen-2017 | Tauro, M; Laghezza, A; Tortorella, P; Lynch, Cc | |
| Abstract P6-16-02: Treatment of skeletal metastatic breast cancer with bone seeking matrix metalloproteinase inhibitors | 1-gen-2016 | Tauro, M; Laghezza, Antonio; Tortorella, Paolo; Lynch, Cc | |
| Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica | 1-gen-2010 | Piemontese, L; Parente, M; Fracchiolla, Giuseppe; Laghezza, Antonio; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, F. | |
| AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. | 1-gen-2010 | Piemontese, Luca; Mariagiovanna, Parente; Fracchiolla, Giuseppe; Laghezza, Antonio; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, Fulvio | |
| AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis | 1-gen-2024 | Lomuscio, Maria Cristina; Abate, Carmen; Alberga, Domenico; Laghezza, Antonio; Corriero, Nicola; Colabufo, Nicola Antonio; Saviano, Michele; Delre, Pietro; Mangiatordi, Giuseppe Felice | |
| An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors | 1-gen-2016 | Tortorella, Paolo; Laghezza, Antonio; Durante, Milena; Gomez Monterrey, Isabel; Bertamino, Alessia; Campiglia, Pietro; Loiodice, Fulvio; Daniele, Simona; Martini, Claudia; Agamennone, Mariangela | |
| An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators | 1-gen-2013 | Piemontese, Luca; Laghezza, Antonio; Fracchiolla, Giuseppe; Carbonara, Giuseppe Gerardo; Tortorella, Paolo; Loiodice, Fulvio |