IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 15.151
AS - Asia 5.809
EU - Europa 5.528
SA - Sud America 1.522
AF - Africa 244
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 5
AN - Antartide 2
Totale 28.270
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Nazione #
US - Stati Uniti d'America 14.916
SG - Singapore 2.188
IT - Italia 1.597
CN - Cina 1.479
BR - Brasile 1.225
DE - Germania 832
SE - Svezia 720
HK - Hong Kong 714
RU - Federazione Russa 698
VN - Vietnam 526
GB - Regno Unito 378
FR - Francia 377
FI - Finlandia 324
UA - Ucraina 215
IN - India 198
BD - Bangladesh 110
CA - Canada 108
AR - Argentina 107
ID - Indonesia 92
IQ - Iraq 76
MX - Messico 74
TR - Turchia 71
NL - Olanda 64
JP - Giappone 62
BE - Belgio 57
CI - Costa d'Avorio 48
CO - Colombia 47
MA - Marocco 44
ZA - Sudafrica 44
ES - Italia 42
AT - Austria 39
PL - Polonia 38
EC - Ecuador 34
PK - Pakistan 34
CZ - Repubblica Ceca 32
IE - Irlanda 30
VE - Venezuela 30
SA - Arabia Saudita 27
UZ - Uzbekistan 27
PY - Paraguay 25
IR - Iran 24
PH - Filippine 21
TN - Tunisia 20
CL - Cile 18
LT - Lituania 18
BO - Bolivia 16
MY - Malesia 16
DZ - Algeria 15
ET - Etiopia 15
NP - Nepal 15
CH - Svizzera 13
JM - Giamaica 13
TW - Taiwan 13
AE - Emirati Arabi Uniti 12
EG - Egitto 12
JO - Giordania 12
KE - Kenya 12
RO - Romania 12
KZ - Kazakistan 11
PE - Perù 11
CR - Costa Rica 10
IL - Israele 10
AZ - Azerbaigian 9
KR - Corea 9
TH - Thailandia 9
OM - Oman 8
AO - Angola 7
NG - Nigeria 7
AL - Albania 6
AU - Australia 6
GT - Guatemala 6
LB - Libano 6
UY - Uruguay 6
KG - Kirghizistan 5
RS - Serbia 5
TT - Trinidad e Tobago 5
AM - Armenia 4
HN - Honduras 4
HU - Ungheria 4
MD - Moldavia 4
PA - Panama 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
SY - Repubblica araba siriana 4
BG - Bulgaria 3
BH - Bahrain 3
DO - Repubblica Dominicana 3
EU - Europa 3
GE - Georgia 3
NI - Nicaragua 3
SN - Senegal 3
BA - Bosnia-Erzegovina 2
BF - Burkina Faso 2
CM - Camerun 2
DK - Danimarca 2
EE - Estonia 2
GN - Guinea 2
ME - Montenegro 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
Totale 28.233
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Città #
Dallas 1.993
Fairfield 1.473
Ashburn 1.406
Singapore 1.146
Woodbridge 1.047
Chandler 837
San Jose 776
Hong Kong 685
Houston 650
Seattle 592
Cambridge 532
Milan 530
Nyköping 527
Wilmington 499
Beijing 475
Jacksonville 468
Ann Arbor 369
Bari 203
Lauterbourg 200
Lawrence 191
Roxbury 190
Rome 186
Helsinki 181
Los Angeles 181
New York 179
Nanjing 168
Ho Chi Minh City 136
Santa Clara 119
Boardman 113
Council Bluffs 109
Des Moines 109
Hanoi 106
Brooklyn 103
São Paulo 93
Princeton 90
Munich 86
San Diego 82
Dong Ket 79
Buffalo 77
Columbus 72
Inglewood 58
Jakarta 57
Falkenstein 54
London 53
Brussels 52
Tokyo 52
Figino 50
Frankfurt am Main 50
Abidjan 48
Nanchang 48
Dearborn 46
Shenyang 46
Paris 45
Hebei 44
Jiaxing 43
Marseille 42
North Bergen 41
Atlanta 40
Rio de Janeiro 40
Chicago 39
Guangzhou 39
Nuremberg 38
Moscow 35
Mexico City 33
The Dalles 33
Turin 33
Baghdad 32
Orem 32
Brasília 31
Dublin 31
Nottingham 31
Naples 29
Redwood City 29
Montreal 28
Shanghai 28
Belo Horizonte 27
Florence 27
Johannesburg 26
Tashkent 26
Tianjin 26
Warsaw 26
Washington 25
Denver 24
Vienna 24
Amsterdam 23
Boston 23
Haiphong 23
Brno 21
Chennai 21
Kansas City 21
San Francisco 21
Toronto 21
Bogotá 20
Changsha 20
Stockholm 20
Boydton 19
Campinas 19
Wuhan 19
Ankara 18
Phoenix 18
Totale 19.046
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.086
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.070
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 257
Applicability Domain for QSAR models: where theory meets reality 253
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 219
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 215
A rational approach to elucidate human monoamine oxidase molecular selectivity 214
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 213
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 210
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 210
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 209
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 208
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 199
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 194
Mind the Gap ! A Journey towards Computational Toxicology 194
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes 191
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 190
CERAPP: Collaborative estrogen receptor activity prediction project 190
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 190
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 189
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 189
Multitarget Drug Design for Neurodegenerative Diseases 187
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 186
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 185
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 184
Ion channels in drug discovery and safety pharmacology 184
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 181
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 180
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 179
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 179
Activation of Rho Family GTPases by Small Molecules 176
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 174
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 172
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 171
Theoretical investigation of hole transporter materials for energy devices 171
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 168
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 168
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 166
Molecular docking for predictive toxicology 165
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 165
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 164
Nontest Methods for REACH Legislation 163
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 161
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 161
Compara: Collaborative modeling project for androgen receptor activity 161
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 160
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 160
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 160
Integration of QSAR models for bioconcentration suitable for REACH 159
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 155
A Round Trip from Medicinal Chemistry to Predictive Toxicology 154
A multi-objective approach to deriving QSAR models 153
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 153
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 151
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 149
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 148
A multitarget approach in cancer research 147
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 147
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 143
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 142
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 142
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 139
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 139
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 139
Strategies of Virtual Screening in Medicinal Chemistry 139
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 139
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 139
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 139
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 138
A Multi-Objective Optimization Algorithm for Molecular Design 138
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 137
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 136
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 134
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 134
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 132
A generalizable definition of chemical similarity for read-across 132
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 131
A chemocentric approach to the identification of cancer targets 130
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 130
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 129
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 128
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 127
A multiobjective approach to deriving QSAR models 126
Estimation of the Binding Free Energy by Linear Interaction Energy Models 125
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 124
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 122
REACH and in silico methods: an attractive opportunity for medicinal chemists 122
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 122
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 121
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 120
Early prediction of ecotoxicological side effects of pharmaceutical impurities based on open-source non-testing approaches 120
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 120
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 119
N-adamantyl-anthranil amide derivatives: New selective ligands for the cannabinoid receptor subtype 2 (CB2R) 119
Totale 17.786
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Categoria #
all - tutte 112.107
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 112.107
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.513 87 180 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.081 58 186 55 143 78 201 42 21 31 50 49 167
2024/20254.290 183 82 312 158 179 387 549 400 195 194 582 1.069
2025/202611.121 1.246 770 2.082 957 996 519 1.000 318 922 885 444 982
2026/2027255 255 0 0 0 0 0 0 0 0 0 0 0
Totale 29.099