IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 14.487
AS - Asia 5.690
EU - Europa 4.596
SA - Sud America 1.507
AF - Africa 243
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 5
AN - Antartide 2
Totale 26.539
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Nazione #
US - Stati Uniti d'America 14.287
SG - Singapore 2.160
CN - Cina 1.443
BR - Brasile 1.220
DE - Germania 832
SE - Svezia 720
HK - Hong Kong 705
RU - Federazione Russa 697
IT - Italia 689
VN - Vietnam 526
GB - Regno Unito 374
FR - Francia 373
FI - Finlandia 324
UA - Ucraina 215
IN - India 193
AR - Argentina 105
ID - Indonesia 90
CA - Canada 89
BD - Bangladesh 78
IQ - Iraq 76
TR - Turchia 71
MX - Messico 68
JP - Giappone 61
NL - Olanda 59
BE - Belgio 57
CI - Costa d'Avorio 48
MA - Marocco 44
ZA - Sudafrica 44
CO - Colombia 41
ES - Italia 40
AT - Austria 39
PL - Polonia 37
EC - Ecuador 34
PK - Pakistan 34
CZ - Repubblica Ceca 31
IE - Irlanda 30
VE - Venezuela 28
SA - Arabia Saudita 27
UZ - Uzbekistan 26
PY - Paraguay 25
IR - Iran 21
PH - Filippine 21
TN - Tunisia 20
CL - Cile 18
LT - Lituania 18
BO - Bolivia 16
MY - Malesia 16
DZ - Algeria 15
ET - Etiopia 15
NP - Nepal 15
TW - Taiwan 13
AE - Emirati Arabi Uniti 12
EG - Egitto 12
JO - Giordania 12
KE - Kenya 12
RO - Romania 12
CH - Svizzera 11
KZ - Kazakistan 11
PE - Perù 11
IL - Israele 10
AZ - Azerbaigian 9
CR - Costa Rica 9
TH - Thailandia 9
KR - Corea 8
OM - Oman 8
AO - Angola 7
JM - Giamaica 7
NG - Nigeria 7
AL - Albania 6
AU - Australia 6
GT - Guatemala 6
LB - Libano 6
UY - Uruguay 6
KG - Kirghizistan 5
TT - Trinidad e Tobago 5
AM - Armenia 4
HN - Honduras 4
HU - Ungheria 4
PA - Panama 4
PS - Palestinian Territory 4
RS - Serbia 4
SK - Slovacchia (Repubblica Slovacca) 4
SY - Repubblica araba siriana 4
BG - Bulgaria 3
BH - Bahrain 3
DO - Repubblica Dominicana 3
EU - Europa 3
GE - Georgia 3
SN - Senegal 3
BA - Bosnia-Erzegovina 2
BF - Burkina Faso 2
CM - Camerun 2
DK - Danimarca 2
EE - Estonia 2
GN - Guinea 2
ME - Montenegro 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
RW - Ruanda 2
Totale 26.507
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Città #
Dallas 1.983
Fairfield 1.473
Ashburn 1.344
Singapore 1.129
Woodbridge 1.047
Chandler 837
Hong Kong 676
San Jose 671
Houston 647
Seattle 590
Cambridge 532
Nyköping 527
Wilmington 498
Jacksonville 467
Beijing 462
Ann Arbor 369
Bari 202
Lauterbourg 200
Lawrence 191
Roxbury 190
Helsinki 181
Los Angeles 169
Nanjing 168
New York 152
Ho Chi Minh City 136
Des Moines 109
Hanoi 106
Council Bluffs 105
Brooklyn 99
São Paulo 92
Princeton 90
Boardman 88
Munich 86
Santa Clara 82
Dong Ket 79
San Diego 79
Buffalo 75
Inglewood 58
Jakarta 57
Falkenstein 54
Milan 53
Brussels 52
London 52
Tokyo 52
Frankfurt am Main 50
Abidjan 48
Nanchang 48
Dearborn 46
Rome 46
Shenyang 46
Paris 45
Hebei 44
Jiaxing 43
Marseille 42
North Bergen 40
Rio de Janeiro 40
Guangzhou 39
Atlanta 38
Nuremberg 38
Chicago 36
Moscow 35
Baghdad 32
Brasília 31
Dublin 31
Nottingham 31
Orem 30
Redwood City 29
The Dalles 29
Belo Horizonte 27
Mexico City 27
Shanghai 27
Johannesburg 26
Tianjin 26
Tashkent 25
Warsaw 25
Vienna 24
Amsterdam 23
Boston 23
Denver 23
Florence 23
Haiphong 23
Washington 23
Brno 21
Chennai 21
Changsha 20
Columbus 20
Kansas City 20
Montreal 20
Stockholm 20
Toronto 20
Campinas 19
Wuhan 19
Ankara 18
Boydton 18
San Francisco 18
Bogotá 17
Da Nang 17
Jinan 17
Poplar 17
Pune 17
Totale 17.930
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.073
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.058
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 248
Applicability Domain for QSAR models: where theory meets reality 240
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 212
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 209
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 208
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 203
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 203
A rational approach to elucidate human monoamine oxidase molecular selectivity 202
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 202
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 200
Mind the Gap ! A Journey towards Computational Toxicology 190
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 186
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 185
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 183
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes 182
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 182
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 182
Multitarget Drug Design for Neurodegenerative Diseases 181
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 178
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 177
CERAPP: Collaborative estrogen receptor activity prediction project 177
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 176
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 176
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 173
Ion channels in drug discovery and safety pharmacology 172
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 168
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 164
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 163
Theoretical investigation of hole transporter materials for energy devices 162
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 162
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 161
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 161
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 160
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 160
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 160
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 159
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 158
Activation of Rho Family GTPases by Small Molecules 158
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 157
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 157
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 156
Molecular docking for predictive toxicology 154
Nontest Methods for REACH Legislation 152
Integration of QSAR models for bioconcentration suitable for REACH 151
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 150
Compara: Collaborative modeling project for androgen receptor activity 149
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 148
A Round Trip from Medicinal Chemistry to Predictive Toxicology 147
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 146
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 146
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 146
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 143
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 143
A multi-objective approach to deriving QSAR models 142
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 142
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 139
A multitarget approach in cancer research 138
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 137
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 137
A Multi-Objective Optimization Algorithm for Molecular Design 136
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 135
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 134
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 134
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 133
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 133
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 133
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 132
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 131
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 131
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 131
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 130
Strategies of Virtual Screening in Medicinal Chemistry 128
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 128
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 128
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 126
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 126
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 126
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 125
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 125
A generalizable definition of chemical similarity for read-across 124
A chemocentric approach to the identification of cancer targets 124
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 123
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 121
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 121
A multiobjective approach to deriving QSAR models 120
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 119
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 119
REACH and in silico methods: an attractive opportunity for medicinal chemists 117
Early prediction of ecotoxicological side effects of pharmaceutical impurities based on open-source non-testing approaches 117
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 116
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 116
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 115
From Flamingo Dance to (Desirable) Drug Discovery: A Nature-Inspired Approach 114
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 113
Strategies of multi-objective optimization in drug discovery and development 112
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering 111
Totale 17.011
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Categoria #
all - tutte 103.366
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 103.366
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021684 0 0 0 0 0 0 0 0 0 320 178 186
2021/20221.513 87 180 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.081 58 186 55 143 78 201 42 21 31 50 49 167
2024/20254.290 183 82 312 158 179 387 549 400 195 194 582 1.069
2025/20269.600 1.246 770 2.082 957 996 519 1.000 318 922 790 0 0
Totale 27.323