IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 15.798
AS - Asia 5.876
EU - Europa 5.589
SA - Sud America 1.547
Continente sconosciuto - Info sul continente non disponibili 834
AF - Africa 245
OC - Oceania 9
AN - Antartide 2
Totale 29.900
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Nazione #
US - Stati Uniti d'America 15.536
SG - Singapore 2.193
IT - Italia 1.635
CN - Cina 1.493
BR - Brasile 1.235
DE - Germania 833
SE - Svezia 721
HK - Hong Kong 718
RU - Federazione Russa 698
VN - Vietnam 528
GB - Regno Unito 386
FR - Francia 382
FI - Finlandia 324
UA - Ucraina 217
IN - India 198
BD - Bangladesh 135
CA - Canada 116
AR - Argentina 110
ID - Indonesia 94
MX - Messico 77
IQ - Iraq 76
TR - Turchia 72
NL - Olanda 64
JP - Giappone 62
BE - Belgio 57
CO - Colombia 52
CI - Costa d'Avorio 48
MA - Marocco 44
ZA - Sudafrica 44
ES - Italia 43
AT - Austria 39
EC - Ecuador 38
PL - Polonia 38
PK - Pakistan 34
CZ - Repubblica Ceca 32
VE - Venezuela 32
SA - Arabia Saudita 31
IE - Irlanda 30
UZ - Uzbekistan 27
PH - Filippine 25
PY - Paraguay 25
IR - Iran 24
TN - Tunisia 20
CL - Cile 18
LT - Lituania 18
MY - Malesia 18
BO - Bolivia 17
CR - Costa Rica 16
DZ - Algeria 15
ET - Etiopia 15
JM - Giamaica 15
NP - Nepal 15
TW - Taiwan 14
CH - Svizzera 13
AE - Emirati Arabi Uniti 12
EG - Egitto 12
JO - Giordania 12
KE - Kenya 12
KZ - Kazakistan 12
RO - Romania 12
PE - Perù 11
IL - Israele 10
TH - Thailandia 10
AZ - Azerbaigian 9
KR - Corea 9
OM - Oman 8
AL - Albania 7
AO - Angola 7
GT - Guatemala 7
NG - Nigeria 7
TT - Trinidad e Tobago 7
AU - Australia 6
HN - Honduras 6
LB - Libano 6
RS - Serbia 6
UY - Uruguay 6
KG - Kirghizistan 5
MD - Moldavia 5
PA - Panama 5
AM - Armenia 4
HU - Ungheria 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
SY - Repubblica araba siriana 4
BA - Bosnia-Erzegovina 3
BG - Bulgaria 3
BH - Bahrain 3
DO - Repubblica Dominicana 3
EU - Europa 3
GE - Georgia 3
NI - Nicaragua 3
PT - Portogallo 3
SN - Senegal 3
BB - Barbados 2
BF - Burkina Faso 2
CM - Camerun 2
DK - Danimarca 2
EE - Estonia 2
GN - Guinea 2
ME - Montenegro 2
Totale 29.030
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Città #
Dallas 1.999
Fairfield 1.473
Ashburn 1.449
Singapore 1.150
Woodbridge 1.047
San Jose 866
Chandler 837
Hong Kong 689
Houston 652
Seattle 594
Milan 534
Cambridge 532
Nyköping 527
Wilmington 499
Beijing 484
Jacksonville 468
Ann Arbor 369
Council Bluffs 343
Bari 204
Lauterbourg 200
Los Angeles 199
Lawrence 191
Roxbury 190
Rome 188
New York 185
Helsinki 181
Nanjing 168
Santa Clara 140
Ho Chi Minh City 136
Boardman 114
Des Moines 109
Hanoi 106
Brooklyn 105
São Paulo 94
Princeton 90
Munich 86
San Diego 85
Buffalo 82
Dong Ket 79
Columbus 73
Inglewood 58
Jakarta 57
Falkenstein 54
London 53
Brussels 52
Tokyo 52
Figino 50
Frankfurt am Main 50
Abidjan 48
Nanchang 48
Paris 47
Dearborn 46
Shenyang 46
Chicago 45
Hebei 44
Jiaxing 43
Marseille 42
Atlanta 41
North Bergen 41
Rio de Janeiro 41
Guangzhou 39
Nuremberg 38
Moscow 35
Turin 35
Mexico City 34
Orem 33
Phoenix 33
The Dalles 33
Baghdad 32
Brasília 32
Dublin 31
Naples 31
Nottingham 31
Florence 29
Montreal 29
Redwood City 29
Shanghai 29
Belo Horizonte 27
Johannesburg 26
Tashkent 26
Tianjin 26
Warsaw 26
Denver 25
Washington 25
San Francisco 24
Vienna 24
Amsterdam 23
Bogotá 23
Boston 23
Haiphong 23
Toronto 23
Brno 21
Chennai 21
Kansas City 21
Stockholm 21
Changsha 20
Boydton 19
Campinas 19
Wuhan 19
Ankara 18
Totale 19.551
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.090
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.074
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 260
Applicability Domain for QSAR models: where theory meets reality 257
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 223
A rational approach to elucidate human monoamine oxidase molecular selectivity 218
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 217
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 216
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 215
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 214
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 212
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 210
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 208
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 197
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes 196
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 196
Mind the Gap ! A Journey towards Computational Toxicology 196
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 195
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 195
CERAPP: Collaborative estrogen receptor activity prediction project 193
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 193
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 192
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 192
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 190
Ion channels in drug discovery and safety pharmacology 190
Multitarget Drug Design for Neurodegenerative Diseases 188
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 187
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 182
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 180
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 180
Activation of Rho Family GTPases by Small Molecules 180
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 178
Theoretical investigation of hole transporter materials for energy devices 176
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 174
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 173
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 173
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 172
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 170
Molecular docking for predictive toxicology 169
Compara: Collaborative modeling project for androgen receptor activity 169
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 168
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 168
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 167
Nontest Methods for REACH Legislation 167
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 165
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 162
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 162
Integration of QSAR models for bioconcentration suitable for REACH 161
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 161
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 161
A Round Trip from Medicinal Chemistry to Predictive Toxicology 157
A multi-objective approach to deriving QSAR models 156
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 156
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 154
A multitarget approach in cancer research 153
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 153
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 150
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 149
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 148
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 147
A Multi-Objective Optimization Algorithm for Molecular Design 145
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 145
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 145
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 145
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 144
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 144
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 143
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 142
Strategies of Virtual Screening in Medicinal Chemistry 142
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 142
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 140
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 140
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 139
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 139
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 138
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 137
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 136
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 135
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 134
A generalizable definition of chemical similarity for read-across 133
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 133
A chemocentric approach to the identification of cancer targets 132
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 130
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 130
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 129
A multiobjective approach to deriving QSAR models 128
Estimation of the Binding Free Energy by Linear Interaction Energy Models 128
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 125
REACH and in silico methods: an attractive opportunity for medicinal chemists 125
Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy 124
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 124
Structure-Based Identification and Design of Angiotensin Converting Enzyme-Inhibitory Peptides from Whey Proteins 124
Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to 124
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 122
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 122
Early prediction of ecotoxicological side effects of pharmaceutical impurities based on open-source non-testing approaches 122
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 122
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 122
Totale 18.109
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Categoria #
all - tutte 115.760
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 115.760
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.246 0 0 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.081 58 186 55 143 78 201 42 21 31 50 49 167
2024/20254.290 183 82 312 158 179 387 549 400 195 194 582 1.069
2025/202611.121 1.246 770 2.082 957 996 519 1.000 318 922 885 444 982
2026/20271.056 295 465 296 0 0 0 0 0 0 0 0 0
Totale 29.900