IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 9.555
EU - Europa 2.897
AS - Asia 1.498
SA - Sud America 44
AF - Africa 16
Continente sconosciuto - Info sul continente non disponibili 3
AN - Antartide 1
OC - Oceania 1
Totale 14.015
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Nazione #
US - Stati Uniti d'America 9.536
CN - Cina 893
SE - Svezia 698
DE - Germania 635
IT - Italia 442
SG - Singapore 419
RU - Federazione Russa 273
GB - Regno Unito 233
UA - Ucraina 194
FI - Finlandia 173
FR - Francia 92
VN - Vietnam 84
BE - Belgio 48
IN - India 45
BR - Brasile 38
NL - Olanda 27
CZ - Repubblica Ceca 24
IE - Irlanda 24
IR - Iran 17
CA - Canada 13
HK - Hong Kong 10
TR - Turchia 9
JP - Giappone 8
LT - Lituania 7
MA - Marocco 5
NG - Nigeria 5
RO - Romania 5
CH - Svizzera 4
BG - Bulgaria 3
DZ - Algeria 3
ES - Italia 3
EU - Europa 3
PL - Polonia 3
AT - Austria 2
CL - Cile 2
EG - Egitto 2
IL - Israele 2
JO - Giordania 2
MX - Messico 2
PA - Panama 2
PE - Perù 2
PK - Pakistan 2
PT - Portogallo 2
AD - Andorra 1
AL - Albania 1
AM - Armenia 1
AR - Argentina 1
AU - Australia 1
CO - Colombia 1
DO - Repubblica Dominicana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HN - Honduras 1
HU - Ungheria 1
ID - Indonesia 1
LB - Libano 1
ME - Montenegro 1
SA - Arabia Saudita 1
SI - Slovenia 1
TH - Thailandia 1
TN - Tunisia 1
TW - Taiwan 1
UZ - Uzbekistan 1
Totale 14.015
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Città #
Fairfield 1.472
Woodbridge 1.047
Chandler 837
Ashburn 723
Houston 635
Seattle 579
Cambridge 532
Nyköping 527
Wilmington 496
Jacksonville 466
Ann Arbor 369
Singapore 332
Lawrence 190
Roxbury 190
Beijing 186
Bari 166
Nanjing 163
Des Moines 106
New York 98
Princeton 89
Boardman 88
Dong Ket 79
San Diego 76
Brooklyn 68
Inglewood 58
Nanchang 48
Milan 47
Dearborn 46
Brussels 44
Hebei 44
Jiaxing 43
Shenyang 43
Helsinki 41
Santa Clara 41
Los Angeles 38
Marseille 38
Guangzhou 35
Paris 35
Rome 32
Munich 30
London 29
Redwood City 29
Shanghai 25
Tianjin 25
Dublin 24
Washington 22
Brno 21
Changsha 19
Kansas City 19
Boydton 18
Jinan 17
Wuhan 17
Norwalk 15
Wuxi 15
Falls Church 14
Pune 14
Leawood 11
Monmouth Junction 11
San Mateo 11
Zhengzhou 10
Ardabil 9
Augusta 9
Bitonto 9
Gravina In Puglia 9
Hong Kong 8
Ningbo 8
Shenzhen 8
Toronto 8
West Jordan 8
Yiwu 8
Amsterdam 7
Naples 7
Prescot 7
Auburn Hills 6
Bergamo 6
Grafing 6
Kilburn 6
Nagold 6
Sheffield 6
Triggiano 6
Frankfurt am Main 5
Hangzhou 5
Hanoi 5
Hounslow 5
Kolkata 5
Mola di Bari 5
Simi Valley 5
Taizhou 5
Acton 4
Cosenza 4
Edinburgh 4
Falkenstein 4
Guwahati 4
Jinhua 4
Kunming 4
Lagos 4
Romola 4
Salice Salentino 4
Secaucus 4
St Albans 4
Totale 10.778
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 221
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 221
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 162
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 157
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 151
Applicability Domain for QSAR models: where theory meets reality 149
Multitarget Drug Design for Neurodegenerative Diseases 148
A rational approach to elucidate human monoamine oxidase molecular selectivity 138
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 137
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 133
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 133
Ion channels in drug discovery and safety pharmacology 133
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 131
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 128
Mind the Gap ! A Journey towards Computational Toxicology 128
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 127
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 125
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 125
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 125
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 124
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 124
Theoretical investigation of hole transporter materials for energy devices 122
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 122
Activation of Rho Family GTPases by Small Molecules 121
Integration of QSAR models for bioconcentration suitable for REACH 120
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 117
Nontest Methods for REACH Legislation 117
Molecular docking for predictive toxicology 116
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 115
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 113
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 113
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 113
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 112
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 112
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 111
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 104
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 103
CERAPP: Collaborative estrogen receptor activity prediction project 101
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 100
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 100
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 100
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 99
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 99
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 97
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 96
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 95
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 95
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 95
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 94
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 94
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 94
A multi-objective approach to deriving QSAR models 93
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 93
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 93
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 92
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 92
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 92
Strategies of Virtual Screening in Medicinal Chemistry 91
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 91
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 90
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 90
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 89
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 88
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 88
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 86
A Round Trip from Medicinal Chemistry to Predictive Toxicology 85
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 85
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 84
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 84
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 84
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 83
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 81
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 81
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 81
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 78
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 78
REACH and in silico methods: an attractive opportunity for medicinal chemists 77
From Flamingo Dance to (Desirable) Drug Discovery: A Nature-Inspired Approach 77
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 76
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering 75
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 75
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 75
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 74
null 74
Compara: Collaborative modeling project for androgen receptor activity 74
A multiobjective approach to deriving QSAR models 73
A multitarget approach in cancer research 73
Solid Phase Synthesis of Safinamide and Analogues as Potent and Selective MAO-B Inhibitors 73
Strategies of multi-objective optimization in drug discovery and development 72
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 72
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 72
A chemocentric approach to the identification of cancer targets 72
A generalizable definition of chemical similarity for read-across 71
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 71
Neuronal nicotinic receptor agonists: multi-approach pharmacophore development and 3D-QSAR predictive models, 70
Estimation of the Binding Free Energy by Linear Interaction Energy Models 70
Computational methods for the design of potent aromatase inhibitors 70
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 69
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 68
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 67
Totale 10.122
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Categoria #
all - tutte 65.622
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 65.622
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.563 0 0 0 0 0 0 300 304 390 199 281 89
2020/20212.433 203 212 112 383 181 193 128 178 159 320 178 186
2021/20221.513 87 180 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.082 58 187 55 143 78 201 42 21 31 50 49 167
2024/20251.308 183 82 312 158 179 389 5 0 0 0 0 0
Totale 14.742