IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 13.213
AS - Asia 4.791
EU - Europa 3.992
SA - Sud America 1.217
AF - Africa 146
Continente sconosciuto - Info sul continente non disponibili 4
OC - Oceania 4
AN - Antartide 2
Totale 23.369
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Nazione #
US - Stati Uniti d'America 13.052
SG - Singapore 1.932
CN - Cina 1.304
BR - Brasile 1.074
DE - Germania 790
SE - Svezia 717
RU - Federazione Russa 684
HK - Hong Kong 657
IT - Italia 554
VN - Vietnam 435
GB - Regno Unito 355
FI - Finlandia 209
UA - Ucraina 206
FR - Francia 155
IN - India 96
CA - Canada 74
ID - Indonesia 69
AR - Argentina 61
BE - Belgio 55
MX - Messico 54
CI - Costa d'Avorio 48
NL - Olanda 47
JP - Giappone 46
TR - Turchia 43
IQ - Iraq 42
AT - Austria 37
BD - Bangladesh 37
ES - Italia 32
PL - Polonia 32
CZ - Repubblica Ceca 30
IE - Irlanda 28
ZA - Sudafrica 24
MA - Marocco 22
IR - Iran 21
LT - Lituania 18
PK - Pakistan 18
EC - Ecuador 17
UZ - Uzbekistan 16
PY - Paraguay 15
CO - Colombia 14
VE - Venezuela 13
RO - Romania 10
DZ - Algeria 9
TN - Tunisia 9
CH - Svizzera 8
CL - Cile 8
CR - Costa Rica 7
NG - Nigeria 7
NP - Nepal 7
PE - Perù 7
SA - Arabia Saudita 7
TW - Taiwan 7
AE - Emirati Arabi Uniti 6
AO - Angola 6
GT - Guatemala 6
JO - Giordania 6
KE - Kenya 6
KR - Corea 6
BO - Bolivia 5
JM - Giamaica 5
KZ - Kazakistan 5
OM - Oman 5
TT - Trinidad e Tobago 5
AL - Albania 4
AZ - Azerbaigian 4
EG - Egitto 4
ET - Etiopia 4
IL - Israele 4
BG - Bulgaria 3
EU - Europa 3
HN - Honduras 3
LB - Libano 3
PA - Panama 3
PH - Filippine 3
SK - Slovacchia (Repubblica Slovacca) 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
CM - Camerun 2
DO - Repubblica Dominicana 2
EE - Estonia 2
ME - Montenegro 2
MY - Malesia 2
PT - Portogallo 2
RS - Serbia 2
SN - Senegal 2
UY - Uruguay 2
AD - Andorra 1
AM - Armenia 1
AQ - Antartide 1
BB - Barbados 1
BF - Burkina Faso 1
BH - Bahrain 1
GA - Gabon 1
GD - Grenada 1
GE - Georgia 1
GF - Guiana Francese 1
GI - Gibilterra 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HU - Ungheria 1
IS - Islanda 1
Totale 23.357
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Città #
Dallas 1.973
Fairfield 1.473
Ashburn 1.213
Woodbridge 1.047
Singapore 967
Chandler 837
Houston 646
Hong Kong 641
Seattle 586
Cambridge 532
Nyköping 527
Wilmington 498
Jacksonville 467
Beijing 443
Ann Arbor 369
Bari 197
Lawrence 190
Roxbury 190
Nanjing 168
Los Angeles 159
New York 141
Ho Chi Minh City 114
Des Moines 107
Brooklyn 95
Princeton 89
Boardman 88
Munich 86
São Paulo 80
Dong Ket 79
Hanoi 78
San Diego 76
Buffalo 72
Helsinki 66
Santa Clara 66
Inglewood 58
Jakarta 54
Brussels 51
Milan 51
Abidjan 48
Nanchang 48
London 47
Dearborn 46
Shenyang 46
Hebei 44
Jiaxing 43
Rome 41
North Bergen 40
Tokyo 40
Marseille 38
Frankfurt am Main 37
Guangzhou 37
Rio de Janeiro 37
Paris 36
Nuremberg 35
Moscow 34
Council Bluffs 33
Chicago 31
Nottingham 31
Falkenstein 30
Dublin 29
Redwood City 29
Brasília 28
Atlanta 27
The Dalles 26
Tianjin 26
Belo Horizonte 25
Shanghai 25
Florence 23
Mexico City 23
Boston 22
Denver 22
Vienna 22
Washington 22
Brno 21
Warsaw 21
Changsha 20
Columbus 20
Haiphong 20
Kansas City 20
Stockholm 19
Toronto 19
Boydton 18
Johannesburg 18
Montreal 18
Wuhan 18
Baghdad 17
Jinan 17
San Jose 17
Amsterdam 16
Ankara 16
Campinas 16
Poplar 16
Pune 16
Tashkent 16
Da Nang 15
Norwalk 15
Wuxi 15
Chennai 14
Falls Church 14
Orem 14
Totale 16.211
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Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 1.054
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 1.038
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 225
Applicability Domain for QSAR models: where theory meets reality 218
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 197
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 192
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 191
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 189
A rational approach to elucidate human monoamine oxidase molecular selectivity 187
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 186
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 186
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 185
Mind the Gap ! A Journey towards Computational Toxicology 176
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 170
Multitarget Drug Design for Neurodegenerative Diseases 169
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 167
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 166
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 166
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 165
Ion channels in drug discovery and safety pharmacology 165
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 162
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 160
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 156
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 156
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 155
CERAPP: Collaborative estrogen receptor activity prediction project 155
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 153
Theoretical investigation of hole transporter materials for energy devices 152
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 152
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 149
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 148
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 147
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 147
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 146
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 146
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 144
Integration of QSAR models for bioconcentration suitable for REACH 143
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 143
Activation of Rho Family GTPases by Small Molecules 143
Nontest Methods for REACH Legislation 142
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 142
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 141
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 141
Molecular docking for predictive toxicology 141
1-Oxa-2,6-Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow-Assisted Preparation and Derivatisation by Strain-Release of Azabicyclo[1.1.0]butanes 140
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 138
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 136
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 134
Compara: Collaborative modeling project for androgen receptor activity 134
A Round Trip from Medicinal Chemistry to Predictive Toxicology 133
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 131
A multi-objective approach to deriving QSAR models 130
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 130
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 129
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 129
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 129
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 127
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 127
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 126
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 125
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 122
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 122
A multitarget approach in cancer research 121
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 121
A Multi-Objective Optimization Algorithm for Molecular Design 121
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 121
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 120
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 120
Strategies of Virtual Screening in Medicinal Chemistry 119
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 117
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 117
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 117
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 117
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 116
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 116
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 116
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 115
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 115
A chemocentric approach to the identification of cancer targets 113
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 112
A generalizable definition of chemical similarity for read-across 112
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 112
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 112
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 111
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 111
A multiobjective approach to deriving QSAR models 109
REACH and in silico methods: an attractive opportunity for medicinal chemists 109
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 108
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 108
From Flamingo Dance to (Desirable) Drug Discovery: A Nature-Inspired Approach 107
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 107
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 103
Estimation of the Binding Free Energy by Linear Interaction Energy Models 103
Computational methods for the design of potent aromatase inhibitors 103
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 103
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering 102
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 101
Early prediction of ecotoxicological side effects of pharmaceutical impurities based on open-source non-testing approaches 100
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 99
Totale 15.550
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Categoria #
all - tutte 97.451
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 97.451
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.342 0 0 0 0 0 193 128 178 159 320 178 186
2021/20221.513 87 180 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.081 58 186 55 143 78 201 42 21 31 50 49 167
2024/20254.290 183 82 312 158 179 387 549 400 195 194 582 1.069
2025/20266.413 1.246 770 2.082 957 996 362 0 0 0 0 0 0
Totale 24.136