IRIS
NICOLOTTI, ORAZIO
 Distribuzione geografica
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Continente #
NA - Nord America 9.652
EU - Europa 3.443
AS - Asia 1.742
SA - Sud America 281
AF - Africa 39
Continente sconosciuto - Info sul continente non disponibili 3
AN - Antartide 1
OC - Oceania 1
Totale 15.162
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Nazione #
US - Stati Uniti d'America 9.617
CN - Cina 903
SE - Svezia 698
DE - Germania 673
RU - Federazione Russa 669
SG - Singapore 537
IT - Italia 490
BR - Brasile 261
GB - Regno Unito 236
UA - Ucraina 198
FI - Finlandia 188
FR - Francia 93
VN - Vietnam 84
BE - Belgio 51
ID - Indonesia 49
IN - India 45
NL - Olanda 34
HK - Hong Kong 33
AT - Austria 26
IE - Irlanda 25
CZ - Repubblica Ceca 24
CA - Canada 19
IR - Iran 19
TR - Turchia 17
JP - Giappone 12
MA - Marocco 12
IQ - Iraq 11
LT - Lituania 10
MX - Messico 9
AR - Argentina 8
UZ - Uzbekistan 7
PK - Pakistan 6
TN - Tunisia 6
DZ - Algeria 5
NG - Nigeria 5
RO - Romania 5
ZA - Sudafrica 5
CH - Svizzera 4
BD - Bangladesh 3
BG - Bulgaria 3
CL - Cile 3
CO - Colombia 3
EG - Egitto 3
ES - Italia 3
EU - Europa 3
PL - Polonia 3
SA - Arabia Saudita 3
EC - Ecuador 2
EE - Estonia 2
IL - Israele 2
JO - Giordania 2
KE - Kenya 2
PA - Panama 2
PE - Perù 2
PT - Portogallo 2
VE - Venezuela 2
AD - Andorra 1
AL - Albania 1
AM - Armenia 1
AO - Angola 1
AU - Australia 1
AZ - Azerbaigian 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
GT - Guatemala 1
HN - Honduras 1
HU - Ungheria 1
JM - Giamaica 1
KZ - Kazakistan 1
LB - Libano 1
ME - Montenegro 1
OM - Oman 1
PH - Filippine 1
PS - Palestinian Territory 1
RS - Serbia 1
SI - Slovenia 1
TH - Thailandia 1
TW - Taiwan 1
Totale 15.162
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Città #
Fairfield 1.472
Woodbridge 1.047
Chandler 837
Ashburn 724
Houston 635
Seattle 580
Cambridge 532
Nyköping 527
Wilmington 496
Jacksonville 466
Ann Arbor 369
Singapore 339
Bari 195
Lawrence 190
Roxbury 190
Beijing 186
Nanjing 168
Des Moines 106
New York 98
Princeton 89
Boardman 88
Dong Ket 79
San Diego 76
Brooklyn 68
Inglewood 58
Helsinki 56
Jakarta 48
Milan 48
Nanchang 48
Brussels 47
Dearborn 46
Hebei 44
Jiaxing 43
Shenyang 43
Los Angeles 41
Santa Clara 41
North Bergen 40
Marseille 38
Guangzhou 35
Paris 35
Moscow 33
London 32
Rome 32
Munich 30
Redwood City 29
Nuremberg 27
Dublin 25
Hong Kong 25
Shanghai 25
Tianjin 25
Washington 22
Brno 21
Changsha 19
Kansas City 19
Boydton 18
Jinan 17
Wuhan 17
Vienna 16
Council Bluffs 15
Falkenstein 15
Norwalk 15
Wuxi 15
Falls Church 14
Pune 14
São Paulo 14
Leawood 11
Monmouth Junction 11
San Mateo 11
Zhengzhou 10
Ardabil 9
Augusta 9
Bitonto 9
Brasília 9
Gravina In Puglia 9
Rio de Janeiro 9
Toronto 9
Amsterdam 8
Belo Horizonte 8
Ningbo 8
Shenzhen 8
West Jordan 8
Yiwu 8
Frankfurt am Main 7
Naples 7
Prescot 7
Tashkent 7
Tokyo 7
Auburn Hills 6
Bergamo 6
Grafing 6
Kilburn 6
Nagold 6
Sheffield 6
Tehran 6
Triggiano 6
Curitiba 5
Hangzhou 5
Hanoi 5
Hounslow 5
Kolkata 5
Totale 11.064
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Nome #
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 236
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 230
A New Approach for Drug Target and Bioactivity Prediction: The Multifingerprint Similarity Search Algorithm (MuSSeL) 179
Multidisciplinary study of a new ClC-1 mutation causing myotonia congenita: a paradigm to understand and treat ion channelopathies 173
Applicability Domain for QSAR models: where theory meets reality 160
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 158
A rational approach to elucidate human monoamine oxidase molecular selectivity 151
Multitarget Drug Design for Neurodegenerative Diseases 151
Challenging AQP4 druggability for NMO-IgG antibody binding using molecular dynamics and molecular interaction fields 150
Mapping ligand binding pockets in ClC-1 channels through an integrated in silico and experimental approach using anthracene-9-carboxylic acid and niflumic acid 148
Design and synthesis of fluorescent ligands for the detection of cannabinoid type 2 receptor (CB2R) 142
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 141
Human aquaporin-4 and molecular modeling: Historical perspective and view to the future 139
Ion channels in drug discovery and safety pharmacology 138
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach 136
Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors 136
Mind the Gap ! A Journey towards Computational Toxicology 131
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 130
A new gating site in human aquaporin-4: Insights from molecular dynamics simulations 130
Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies 128
Nitazoxanide inhibits paramyxovirus replication by targeting the Fusion protein folding: Role of glycoprotein-specific thiol oxidoreductase ERp57 128
ClC-1 mutations in myotonia congenita patients: insights into molecular gating mechanisms and genotype-phenotype correlation 127
Effects of Different Self-Assembled Monolayers on Thin-Film Morphology: A Combined DFT/MD Simulation Protocol 126
Theoretical investigation of hole transporter materials for energy devices 125
Analysis of solvent-exposed and buried co-crystallized ligands: a case study to support the design of novel protein–protein interaction inhibitors 125
Activation of Rho Family GTPases by Small Molecules 124
Integration of QSAR models for bioconcentration suitable for REACH 122
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 122
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 121
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 121
Molecular docking for predictive toxicology 121
Bcr-abl tyrosine kinase inhibitors in the treatment of pediatric cml 121
Nontest Methods for REACH Legislation 119
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 118
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 113
CERAPP: Collaborative estrogen receptor activity prediction project 110
A novel KCNA1 mutation in a patient with paroxysmal ataxia, myokymia, painful contractures and metabolic dysfunctions 110
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 109
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 107
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 107
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 103
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 103
Persulfate Reaction in a Hair-Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13-Diamino-4,7,10-Trioxatridecane 103
Comparative Molecular Dynamics Study of Neuromyelitis Optica-Immunoglobulin G Binding to Aquaporin-4 Extracellular Domains 102
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 101
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 101
A multi-objective approach to deriving QSAR models 100
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 100
Design, synthesis, biological evaluation, NMR and DFT studies of structurally-simplified trimethoxy benzamides as P-glycoprotein selective inhibitors: the role of molecular flatness 100
A k-NN algorithm for predicting oral sub-chronic toxicity in the rat 98
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 97
Predictive Structure-Based Toxicology Approaches to Assess the Androgenic Potential of Chemicals 97
Activity cliffs in drug discovery: Dr Jekyll or Mr Hyde? 96
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands 96
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 96
Pharmacovigilance database search discloses ClC-K channels as a novel target of the AT1 receptor blockers valsartan and olmesartan 96
Strategies of Virtual Screening in Medicinal Chemistry 95
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 95
A Round Trip from Medicinal Chemistry to Predictive Toxicology 94
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 93
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 93
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 93
Piano-stool d6-rhodium(III) complexes of chelating pyridine-based ligands and their papain bioconjugates for the catalysis of transfer hydrogenation of aryl ketones in aqueous medium 92
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 92
Ethoxylated Head of Chalcones as a New Class of Multi-Targeted MAO Inhibitors 91
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 90
8-Substituted- 9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B 90
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 90
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 89
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 88
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 87
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 86
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 86
Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics 86
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 85
Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data 85
Investigating Enzyme Selectivity and Hit Enrichment by Automatically Interfacing Ligand- and Structure-Based Molecular Design 84
A multitarget approach in cancer research 83
A generalizable definition of chemical similarity for read-across 83
Compara: Collaborative modeling project for androgen receptor activity 83
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 82
A multiobjective approach to deriving QSAR models 80
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 79
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 79
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 79
De Novo Drug Design of Targeted Chemical Libraries Based on Artificial Intelligence and Pair-Based Multiobjective Optimization 79
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 78
A chemocentric approach to the identification of cancer targets 78
REACH and in silico methods: an attractive opportunity for medicinal chemists 77
From Flamingo Dance to (Desirable) Drug Discovery: A Nature-Inspired Approach 77
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 76
Analysis of X-ray Structures of Matrix Metalloproteinases via Chaotic Map Clustering 76
A Multi-Objective Optimization Algorithm for Molecular Design 76
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 76
9-Deazaxanthines as selective A2B AR ligands: Design, Synthesis and SAFIR studies 75
Estimation of the Binding Free Energy by Linear Interaction Energy Models 75
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 75
Strategies of multi-objective optimization in drug discovery and development 74
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 74
null 74
Totale 10.724
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Categoria #
all - tutte 71.799
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.799
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020569 0 0 0 0 0 0 0 0 0 199 281 89
2020/20212.433 203 212 112 383 181 193 128 178 159 320 178 186
2021/20221.513 87 180 29 26 70 106 82 81 101 161 214 376
2022/20232.357 376 282 165 180 271 295 38 262 344 30 67 47
2023/20241.081 58 186 55 143 78 201 42 21 31 50 49 167
2024/20252.487 183 82 312 158 179 387 549 400 195 42 0 0
Totale 15.920