IRIS
CAVALLUZZI, MARIA MADDALENA
 Distribuzione geografica
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Continente #
NA - Nord America 3.947
EU - Europa 970
AS - Asia 430
SA - Sud America 9
OC - Oceania 6
AF - Africa 3
Continente sconosciuto - Info sul continente non disponibili 1
Totale 5.366
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Nazione #
US - Stati Uniti d'America 3.936
CN - Cina 353
SE - Svezia 291
IT - Italia 274
UA - Ucraina 111
FI - Finlandia 72
DE - Germania 71
GB - Regno Unito 57
FR - Francia 36
SG - Singapore 24
BE - Belgio 22
IN - India 20
VN - Vietnam 13
IE - Irlanda 11
CA - Canada 10
NL - Olanda 6
AU - Australia 5
BR - Brasile 5
RU - Federazione Russa 4
CZ - Repubblica Ceca 3
IR - Iran 3
JP - Giappone 3
KR - Corea 3
RO - Romania 3
BO - Bolivia 2
EG - Egitto 2
ES - Italia 2
HK - Hong Kong 2
RS - Serbia 2
SA - Arabia Saudita 2
TH - Thailandia 2
TR - Turchia 2
BD - Bangladesh 1
CH - Svizzera 1
EC - Ecuador 1
EE - Estonia 1
EU - Europa 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
HR - Croazia 1
HU - Ungheria 1
IL - Israele 1
MX - Messico 1
NZ - Nuova Zelanda 1
PL - Polonia 1
ZA - Sudafrica 1
Totale 5.366
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Città #
Fairfield 535
Chandler 400
Woodbridge 321
Ashburn 285
Houston 268
Jacksonville 262
Nyköping 240
Seattle 232
Cambridge 198
Ann Arbor 178
Wilmington 178
Bari 90
Lawrence 90
Roxbury 89
New York 83
Nanjing 72
Beijing 57
Des Moines 56
Princeton 56
Boardman 40
Inglewood 30
San Diego 29
Brooklyn 26
Jiaxing 22
Brussels 21
London 18
Los Angeles 17
Shenyang 17
Rome 16
Guangzhou 15
Hebei 15
Paris 15
Dearborn 13
Dong Ket 13
Nanchang 13
Pune 12
Tianjin 12
Dublin 11
Changsha 10
Marseille 10
San Francisco 10
Singapore 10
Wuhan 10
Toronto 9
Leawood 8
Redwood City 8
Milan 7
Brescia 6
Jinan 6
Norwalk 6
San Mateo 6
Shanghai 6
Triggiano 6
Washington 6
Hefei 5
Kilburn 5
Zhengzhou 5
Bologna 4
Helsinki 4
Melbourne 4
Mumbai 4
Wuxi 4
Ardabil 3
Belém 3
Bitonto 3
Florence 3
Fuzhou 3
Kunming 3
Lentini 3
Naples 3
Palermo 3
Adelfia 2
Arnesano 2
Auburn Hills 2
Augusta 2
Cairo 2
Chengdu 2
Chicago 2
Chongqing 2
Council Bluffs 2
Dongguan 2
Ferrara 2
Genoa 2
Haikou 2
Hanover 2
Hartford 2
Indiana 2
Islington 2
Kiev 2
Kowloon 2
Lucera 2
Madrid 2
Molfetta 2
Monmouth Junction 2
Novi Sad 2
Phoenix 2
Pontassieve 2
Qingdao 2
Riyadh 2
San Giovanni Rotondo 2
Totale 4.289
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Nome #
A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells 115
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 114
The chemistry and pharmacology of citrus limonoids 110
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma 108
Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods 107
Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents 106
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II 105
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 105
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs 104
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers 101
Recent trends in the discovery of small molecule blockers of sodium channels 100
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II 98
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites 93
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 92
Fitocomplesso polifenolico standardizzato per la prevenzione delle patologie correlate all’esposizione da sostanze reattive dell’ossigeno e relativo metodo di produzione 92
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 90
null 90
2-Arylazetidines as ligands for nicotinic acetylcholine receptors 88
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 84
A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues 84
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 83
Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens 81
Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination 80
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 80
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 78
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 78
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate 77
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 75
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents 74
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 72
Discovery of a new mexiletine-derived agonist of the hERG K+channel 72
Lubeluzole: from anti-ischemic to chemosensitizing agent 71
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 70
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition 68
2-(9-Antryl)alcanoic acids as chloride channel modulators 67
null 64
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine 62
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite 62
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole 60
Applicazione di un disegno sperimentale alla sintesi enantiospecifica one-step dell’acido O-fenilmandelico, utile agente di solvatazione chirale 57
Preclinical in vitro and in vivo evaluation of sodium channel blockers as possible alternative to mexiletine in the treatment of myotonia 57
Stereospecific Synthesis of p-Hydroxymexiletine and Hydroxymethylmexiletine: the two Main Metabolites of Mexiletine 56
null 56
Covid-19, chloroquine repurposing, and cardiac safety concern: Chirality might help 56
null 56
New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase 55
Molecular determinants of human voltage-gated sodium channel blockade by lubeluzole 54
Derivati idrossilati della mexiletina come tools farmacologici nello studio dell'attività di blocco dei canali sodici 54
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 54
ANTIARRHYTHMIC AGENTS ENDOWED WITH ANTIOXIDANT PROPERTIES 53
Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function 53
Applicazione di un disegno sperimentale alla sintesi enantiospecifica one-step dell'acido O-fenilmandelico, utile agente di solvatazione chirale 52
Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels 51
Mexiletine analogues as potent skeletal muscle sodium channel blockers: hypotheses on the interactions at the main binding sites 49
Sintesi enantiospecifica one-step di acidi O-aril ed O-eteroaril mandelici, utilizzabili come agenti di solvatazione chirale 48
Separation and quantitative determination of mexiletine and its metabolites by capillary zone electrophoresis 48
Targeting the pregnane X receptor using microbial metabolite mimicry 48
Synthesis of 7a-[2(2,6-dimethylphenoxy)ethyl]hexahydro-1H-pyrrolizine, bioisostere of pilsicainide 46
Metabolic derivatives of antiarrhythmic drugs: stereospecific synthesis of N-hydroxymexiletine and meta-hydroxymexiletine 45
Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels 44
Metabolic derivatives of antiarrhythmic drugs: stereospecific synthesis of N-hydroxymexiletine and meta-hydroxymexiletine 43
Sintesi alternativa del lubeluzolo e del suo enantiomero e valutazione come agenti in grado di potenziare l'effetto di farmaci antitumorali. 43
Separazione e determinazione quantitativa dei principali prodotti di degradazione metabolica e chimica della mexiletina mediante elettroforesi capillare zonale 42
Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction 42
Evaluation of the dual action of new derivatives of mexiletine as usedependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 41
Design of a pharmacological rat model of myotonia congenita for antimyotonic drug screening 38
Mexiletine analogues as potent skeletal muscle sodium channel blockers: hypotheses on the interaction at the main binding sites 37
Proprietà antiossidanti dell'uva di troia canosina ad acino piccolo: confronto tra diversi metodi estrattivi 37
Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials 37
Erratum: Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels 36
Molecular simplification of natural products: Synthesis, antibacterial activity, and molecular docking studies of berberine open models 36
Efficient Routes to Lubeluzole, Its Enantiomer, and Racemate 34
Dual-Acting Drugs: Antioxidant Activity of Voltage-Gated Sodium Channel Blocking Agents Coupled to a Pyrroline Moiety 33
Voltage-gated sodium channel blocking agents coupled to a ros scavenging pyrroline moiety as dual-acting twin drugs 32
Evaluation of the dual action of new derivatives of mexiletine as use-dependent sodium channel blockers and antioxidant: potential therapeutic application in neuromuscular disorders 31
Riconoscimento degli alogenuri mediante cromatografia su carta: disegno sperimentale (DoE) applicato alla individuazione della miscela ottimale 30
Label-free, reagentless, straightforward capillary electrophoretic method to individuate potent calmodulin ligands. 29
Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs 27
Separazione e determinazione quantitativa dei principali prodotti di degradazione metabolica e chimica della mexiletina mediante elettroforesi capillare zonale 27
Sintesi della pilsicainide e valutazione della sua attività di blocco sui canali sodici di muscolo scheletrico umano 27
Small Molecules as MT1 And MT2 Ligands: Antioxidant Properties and in vitro Inhibition of Ca2+/CAM-Dependent Kinase II. 27
Dual-acting drugs: antioxidant activity of voltage-gated sodium channel blocking agents coupled to a pyrroline moiety. 27
Small molecules as MT1 and MT2 ligands: antioxidant properties and in vitro inhibition of Ca2+/CaM-dependent kinase II. 26
First synthesis and full characterization of mexiletine N-carbonyloxy beta-D-glucuronide 26
Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR) 26
Xanthenylacetic Acid Derivatives Effectively Target Lysophosphatidic Acid Receptor 6 to Inhibit Hepatocellular Carcinoma Cell Growth 26
Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies 25
Phyllostachys Pubescens: From Traditional to Functional Food: Phyllostachys pubescens as functional food 25
The Crystal Structure of N-[(2E)-3-(4-Chlorophenyl)prop-2-en-1-yl]-4-methoxy-N-methylbenzenesulfonamide 24
Preparation of Chiral 2-(9-Anthryl)Alcanoic Acids, 9-Xanthenyl Isosteres, and Derivatives 23
Riconoscimento degli alogenuri mediante cromatografia su carta: disegno sperimentale (DoE) applicato alla individuazione della miscela di eluizione ottimale 22
Label-free, Reagentless, Straightforward Capillary Electrophoretic Method to Individuate Potent Calmodulin Ligands 22
Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels 22
CONSERVATION, TAXONOMY, ECOLOGICAL DISTRIBUTION, AND POTENTIAL APPLICATION OF THE CULINARYMEDICINAL MUSHROOM LECCINUM SCABRUM 21
Riconoscimento degli alogenuri mediante cromatografia su carta: disegno sperimentale (DoE) applicato alla individuazione della miscela di eluizione ottimale 21
Separation and quantitative determination of mexiletine by capillary zone electrophoresis 20
Targeting Penicillium expansum GMC oxidoreductase with high affinity small molecules for reducing patulin production 19
Microwave-Assisted Extraction of Bioactive Compounds from Lentil Wastes: Antioxidant Activity Evaluation and Metabolomic Characterization 15
Targeting Penicillium expansum transporters with high affinity small molecules for reducing patulin production 13
Lubeluzole Repositioning as Chemosensitizing Agent on Multidrug-Resistant Human Ovarian A2780/DX3 Cancer Cells 12
Totale 5.596
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Categoria #
all - tutte 24.713
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.713
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.278 230 75 30 108 123 64 114 90 173 76 160 35
2020/2021990 198 49 72 65 76 39 77 64 84 125 84 57
2021/2022727 41 113 29 27 5 48 29 29 51 43 112 200
2022/20231.189 170 131 66 96 122 157 17 159 182 17 47 25
2023/2024558 31 78 27 59 32 125 9 31 19 30 50 67
2024/202579 79 0 0 0 0 0 0 0 0 0 0 0
Totale 5.671