IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 14.249
AS - Asia 5.960
EU - Europa 5.139
SA - Sud America 1.620
Continente sconosciuto - Info sul continente non disponibili 677
AF - Africa 220
OC - Oceania 15
Totale 27.880
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Nazione #
US - Stati Uniti d'America 13.990
SG - Singapore 2.386
IT - Italia 1.708
CN - Cina 1.427
BR - Brasile 1.269
HK - Hong Kong 763
SE - Svezia 606
RU - Federazione Russa 499
DE - Germania 473
UA - Ucraina 459
FR - Francia 427
VN - Vietnam 385
FI - Finlandia 342
GB - Regno Unito 310
IN - India 235
BD - Bangladesh 138
CA - Canada 125
AR - Argentina 106
ID - Indonesia 74
IQ - Iraq 69
TR - Turchia 64
EC - Ecuador 61
MX - Messico 61
CO - Colombia 54
PK - Pakistan 50
BE - Belgio 48
AT - Austria 47
JP - Giappone 47
CI - Costa d'Avorio 45
IE - Irlanda 45
VE - Venezuela 41
ZA - Sudafrica 40
PH - Filippine 39
PL - Polonia 36
SA - Arabia Saudita 35
MA - Marocco 32
ES - Italia 30
MY - Malesia 28
UZ - Uzbekistan 25
CL - Cile 23
NL - Olanda 23
IR - Iran 21
PE - Perù 20
JO - Giordania 19
KE - Kenya 19
PY - Paraguay 19
EG - Egitto 18
TW - Taiwan 17
KR - Corea 16
TN - Tunisia 15
AU - Australia 13
CR - Costa Rica 13
NP - Nepal 13
AE - Emirati Arabi Uniti 12
AL - Albania 12
BO - Bolivia 12
CH - Svizzera 12
LT - Lituania 12
UY - Uruguay 12
JM - Giamaica 11
OM - Oman 11
PT - Portogallo 10
AZ - Azerbaigian 9
LB - Libano 9
TT - Trinidad e Tobago 9
CZ - Repubblica Ceca 8
DZ - Algeria 8
ET - Etiopia 8
BH - Bahrain 7
HN - Honduras 7
KG - Kirghizistan 7
KZ - Kazakistan 7
TH - Thailandia 7
DK - Danimarca 6
IL - Israele 6
NI - Nicaragua 6
EU - Europa 5
GE - Georgia 5
PA - Panama 5
SV - El Salvador 5
AO - Angola 4
LY - Libia 4
PS - Palestinian Territory 4
RS - Serbia 4
SN - Senegal 4
SY - Repubblica araba siriana 4
BB - Barbados 3
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
GA - Gabon 3
GT - Guatemala 3
HU - Ungheria 3
KW - Kuwait 3
PR - Porto Rico 3
RO - Romania 3
TJ - Tagikistan 3
XK - ???statistics.table.value.countryCode.XK??? 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AD - Andorra 2
Totale 27.160
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Città #
Ashburn 1.281
Singapore 1.199
Fairfield 1.152
Chandler 1.059
Jacksonville 995
San Jose 980
Woodbridge 812
Hong Kong 743
Milan 698
Houston 600
Cambridge 526
Seattle 476
Nyköping 468
Council Bluffs 390
Ann Arbor 382
Wilmington 381
Beijing 345
Lawrence 261
Roxbury 259
Lauterbourg 237
Dallas 228
Nanjing 227
New York 214
Princeton 181
Rome 181
Los Angeles 176
Boardman 162
Ho Chi Minh City 153
Des Moines 150
Bari 148
Santa Clara 142
Inglewood 113
Helsinki 112
São Paulo 95
Hanoi 77
Brooklyn 69
Chicago 68
Figino 67
Nanchang 66
Munich 61
Buffalo 60
Jiaxing 58
San Diego 56
Hebei 55
London 55
Naples 55
Frankfurt am Main 51
Brussels 47
Shenyang 47
Abidjan 45
Columbus 44
Dublin 44
Jakarta 43
Tokyo 42
Turin 42
Moscow 38
Rio de Janeiro 37
San Francisco 37
Orem 36
Baghdad 35
Chennai 35
Tianjin 35
Washington 35
Phoenix 34
Toronto 34
Atlanta 33
Changsha 33
Marseille 31
Paris 30
Dong Ket 27
Montreal 27
Belo Horizonte 26
Leawood 26
North Bergen 26
Warsaw 26
Denver 25
Tashkent 24
Dearborn 23
Johannesburg 23
Mexico City 23
Campinas 22
Guangzhou 22
Poplar 21
Augusta 20
Florence 20
Fragagnano 20
Manchester 20
Boston 19
Curitiba 19
Guayaquil 19
Nuremberg 19
Boydton 18
Falkenstein 18
Pune 18
Quito 18
Wuhan 18
Bologna 17
Lahore 17
Brasília 16
Caracas 16
Totale 17.814
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 239
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 211
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 211
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 208
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 199
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 195
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 194
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 192
Activation and inhibition of kidney CLC-K chloride channels by fenamates 190
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 175
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 169
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 169
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 168
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 166
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 166
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 164
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 163
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 162
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 161
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 159
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 159
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 159
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 158
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 155
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 155
Le applicazioni della chimica farmaceutica 155
Facile entry to (-)-R- and (+)-(S)-mexiletine 155
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 154
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 152
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 150
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 149
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 149
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 145
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 144
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 142
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 141
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 141
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 140
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 138
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 138
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 137
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 136
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 135
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 135
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 134
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 133
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 133
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 133
Structural development studies of PPARs ligands based on tyrosine scaffold. 132
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 132
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 132
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 131
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 130
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 130
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 129
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 129
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 129
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 128
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 126
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 125
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 125
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 125
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 124
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 124
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 124
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 123
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 122
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 122
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 120
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 120
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 120
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 120
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 120
Mimic catechins to develop selective MMP-2 inhibitors 119
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 118
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 116
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 116
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 116
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 115
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 115
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 113
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 112
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 112
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 110
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 109
Resveratrol and Its Metabolites Bind to PPARs 109
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 108
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 108
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 108
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents 108
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 107
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 107
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 106
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 106
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 106
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 106
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 105
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 105
Totale 13.860
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Categoria #
all - tutte 119.892
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 119.892
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.371 0 0 22 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/20254.033 183 88 398 153 103 271 338 370 180 232 506 1.211
2025/20269.037 1.109 466 606 1.073 877 453 1.018 280 774 897 305 1.179
2026/20271.246 265 496 485 0 0 0 0 0 0 0 0 0
Totale 27.880