IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 15.584
AS - Asia 5.967
EU - Europa 5.233
SA - Sud America 1.652
Continente sconosciuto - Info sul continente non disponibili 683
AF - Africa 220
OC - Oceania 15
Totale 29.354
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Nazione #
US - Stati Uniti d'America 15.263
SG - Singapore 2.387
IT - Italia 1.788
CN - Cina 1.429
BR - Brasile 1.298
HK - Hong Kong 763
SE - Svezia 606
RU - Federazione Russa 499
DE - Germania 476
UA - Ucraina 459
FR - Francia 429
VN - Vietnam 385
FI - Finlandia 342
GB - Regno Unito 315
IN - India 235
CA - Canada 162
BD - Bangladesh 138
AR - Argentina 106
ID - Indonesia 75
IQ - Iraq 69
TR - Turchia 65
EC - Ecuador 62
MX - Messico 61
CO - Colombia 55
PK - Pakistan 50
BE - Belgio 48
JP - Giappone 48
AT - Austria 47
CI - Costa d'Avorio 45
IE - Irlanda 45
VE - Venezuela 42
PH - Filippine 40
ZA - Sudafrica 40
PL - Polonia 37
SA - Arabia Saudita 35
MA - Marocco 32
ES - Italia 31
MY - Malesia 28
UZ - Uzbekistan 25
CL - Cile 23
NL - Olanda 23
IR - Iran 21
PE - Perù 20
JO - Giordania 19
KE - Kenya 19
PY - Paraguay 19
EG - Egitto 18
TW - Taiwan 17
CR - Costa Rica 16
KR - Corea 16
TN - Tunisia 15
AU - Australia 13
LT - Lituania 13
NP - Nepal 13
TT - Trinidad e Tobago 13
AE - Emirati Arabi Uniti 12
AL - Albania 12
BO - Bolivia 12
CH - Svizzera 12
JM - Giamaica 12
UY - Uruguay 12
OM - Oman 11
NI - Nicaragua 10
PT - Portogallo 10
AZ - Azerbaigian 9
HN - Honduras 9
LB - Libano 9
CZ - Repubblica Ceca 8
DZ - Algeria 8
ET - Etiopia 8
SV - El Salvador 8
BH - Bahrain 7
KG - Kirghizistan 7
KZ - Kazakistan 7
TH - Thailandia 7
DK - Danimarca 6
GT - Guatemala 6
IL - Israele 6
PA - Panama 6
EU - Europa 5
GE - Georgia 5
PR - Porto Rico 5
AO - Angola 4
BB - Barbados 4
LY - Libia 4
PS - Palestinian Territory 4
RS - Serbia 4
SN - Senegal 4
SY - Repubblica araba siriana 4
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
EE - Estonia 3
GA - Gabon 3
HU - Ungheria 3
KW - Kuwait 3
RO - Romania 3
TJ - Tagikistan 3
XK - ???statistics.table.value.countryCode.XK??? 3
ZW - Zimbabwe 3
A1 - Anonimo 2
Totale 28.627
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Città #
Ashburn 1.751
Singapore 1.199
Fairfield 1.152
San Jose 1.141
Chandler 1.059
Jacksonville 995
Woodbridge 812
Hong Kong 743
Milan 708
Houston 602
Cambridge 526
Seattle 476
Nyköping 468
Council Bluffs 418
Ann Arbor 382
Wilmington 381
Beijing 345
Lawrence 261
Roxbury 259
Lauterbourg 237
Dallas 231
New York 228
Nanjing 227
Los Angeles 193
Rome 192
Princeton 183
Boardman 163
Santa Clara 156
Ho Chi Minh City 153
Des Moines 150
Bari 149
São Paulo 119
Inglewood 113
Helsinki 112
Washington 102
Hanoi 77
Brooklyn 73
Chicago 70
Figino 70
Nanchang 66
Munich 61
Buffalo 60
Jiaxing 58
Naples 57
London 56
San Diego 56
Hebei 55
Frankfurt am Main 51
Toronto 48
Brussels 47
Shenyang 47
Abidjan 45
Columbus 45
Dublin 44
Jakarta 43
Tokyo 43
Turin 42
Atlanta 40
Moscow 38
Phoenix 38
Rio de Janeiro 37
San Francisco 37
Orem 36
Baghdad 35
Chennai 35
Tianjin 35
Changsha 33
Marseille 31
Montreal 31
North Bergen 30
Paris 30
Denver 28
Dong Ket 27
Warsaw 27
Belo Horizonte 26
Leawood 26
Tashkent 24
Dearborn 23
Johannesburg 23
Mexico City 23
Campinas 22
Guangzhou 22
Bologna 21
Florence 21
Poplar 21
Augusta 20
Brasília 20
Fragagnano 20
Manchester 20
Boston 19
Curitiba 19
Guayaquil 19
Nuremberg 19
Quito 19
Boydton 18
Falkenstein 18
Pune 18
Wuhan 18
Lahore 17
Caracas 16
Totale 18.700
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 244
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 218
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 218
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 216
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 211
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 207
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 203
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 200
Activation and inhibition of kidney CLC-K chloride channels by fenamates 193
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 185
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 185
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 180
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 175
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 174
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 171
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 170
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 170
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 168
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 168
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 166
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 165
Facile entry to (-)-R- and (+)-(S)-mexiletine 164
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 164
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 164
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 163
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 161
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 158
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 158
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 158
Le applicazioni della chimica farmaceutica 156
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 152
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 151
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 150
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 148
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 146
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 146
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 146
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 144
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 144
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 143
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 142
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 142
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 140
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 140
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 139
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 139
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 138
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 138
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 138
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 138
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 137
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 137
Structural development studies of PPARs ligands based on tyrosine scaffold. 135
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 134
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 134
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 134
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 133
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 133
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 132
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 130
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 130
Effects of new K+ channel openers (2H-[1, 4]-benzoxazin-3-one derivatives) on skeletal muscle K-ATP channel. 128
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 128
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 128
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 128
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 128
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 127
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 127
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 127
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 127
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 126
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 125
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 125
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 124
Mimic catechins to develop selective MMP-2 inhibitors 124
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 124
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 123
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 123
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 123
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 123
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 120
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 120
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 119
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 119
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 119
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 119
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 118
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 117
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 116
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 116
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 116
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 114
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 114
Selective MMP inhibitors for the treatment of skeletal malignancy. 112
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents 112
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 111
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 111
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 111
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 111
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 111
Totale 14.460
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Categoria #
all - tutte 125.077
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 125.077
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.349 0 0 0 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/20254.033 183 88 398 153 103 271 338 370 180 232 506 1.211
2025/20269.037 1.109 466 606 1.073 877 453 1.018 280 774 897 305 1.179
2026/20272.720 265 496 995 964 0 0 0 0 0 0 0 0
Totale 29.354