IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 13.329
AS - Asia 5.909
EU - Europa 5.109
SA - Sud America 1.596
AF - Africa 217
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 9
Totale 26.184
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Nazione #
US - Stati Uniti d'America 13.100
SG - Singapore 2.382
IT - Italia 1.682
CN - Cina 1.420
BR - Brasile 1.264
HK - Hong Kong 755
SE - Svezia 606
RU - Federazione Russa 499
DE - Germania 473
UA - Ucraina 459
FR - Francia 427
VN - Vietnam 382
FI - Finlandia 342
GB - Regno Unito 307
IN - India 232
BD - Bangladesh 127
CA - Canada 111
AR - Argentina 104
ID - Indonesia 72
IQ - Iraq 69
TR - Turchia 63
MX - Messico 60
EC - Ecuador 53
PK - Pakistan 50
BE - Belgio 48
AT - Austria 47
CO - Colombia 47
JP - Giappone 47
CI - Costa d'Avorio 45
IE - Irlanda 45
VE - Venezuela 40
ZA - Sudafrica 40
PH - Filippine 36
PL - Polonia 36
MA - Marocco 32
SA - Arabia Saudita 32
ES - Italia 30
MY - Malesia 27
UZ - Uzbekistan 25
CL - Cile 23
NL - Olanda 22
IR - Iran 21
PE - Perù 20
JO - Giordania 19
KE - Kenya 19
PY - Paraguay 19
EG - Egitto 18
TW - Taiwan 17
KR - Corea 16
TN - Tunisia 15
AU - Australia 13
AE - Emirati Arabi Uniti 12
AL - Albania 12
CH - Svizzera 12
LT - Lituania 12
NP - Nepal 12
UY - Uruguay 12
BO - Bolivia 11
OM - Oman 10
PT - Portogallo 10
AZ - Azerbaigian 9
CR - Costa Rica 9
JM - Giamaica 9
CZ - Repubblica Ceca 8
DZ - Algeria 8
ET - Etiopia 8
LB - Libano 8
BH - Bahrain 7
KG - Kirghizistan 7
KZ - Kazakistan 7
DK - Danimarca 6
IL - Israele 6
TT - Trinidad e Tobago 6
EU - Europa 5
GE - Georgia 5
HN - Honduras 5
NI - Nicaragua 5
PA - Panama 5
TH - Thailandia 5
AO - Angola 4
LY - Libia 4
PS - Palestinian Territory 4
RS - Serbia 4
SN - Senegal 4
SV - El Salvador 4
SY - Repubblica araba siriana 4
BB - Barbados 3
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
GA - Gabon 3
HU - Ungheria 3
KW - Kuwait 3
RO - Romania 3
TJ - Tagikistan 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AD - Andorra 2
AM - Armenia 2
BG - Bulgaria 2
EE - Estonia 2
Totale 26.134
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Città #
Ashburn 1.257
Singapore 1.196
Fairfield 1.152
Chandler 1.059
Jacksonville 994
Woodbridge 812
San Jose 751
Hong Kong 738
Milan 698
Houston 599
Cambridge 526
Seattle 474
Nyköping 468
Ann Arbor 382
Wilmington 380
Beijing 340
Lawrence 261
Roxbury 259
Lauterbourg 237
Nanjing 227
Dallas 214
New York 209
Princeton 181
Rome 179
Los Angeles 170
Boardman 161
Ho Chi Minh City 152
Des Moines 150
Bari 147
Santa Clara 115
Inglewood 113
Helsinki 112
São Paulo 95
Council Bluffs 88
Hanoi 77
Brooklyn 67
Figino 67
Nanchang 66
Munich 61
Jiaxing 58
Hebei 55
London 55
San Diego 55
Naples 54
Buffalo 53
Chicago 53
Frankfurt am Main 51
Brussels 47
Shenyang 47
Abidjan 45
Dublin 44
Jakarta 43
Columbus 42
Tokyo 42
Turin 41
Moscow 38
Orem 36
Rio de Janeiro 36
Baghdad 35
Chennai 35
Tianjin 35
Washington 34
Changsha 33
Atlanta 32
San Francisco 32
Toronto 32
Marseille 31
Paris 30
Dong Ket 27
Leawood 26
North Bergen 26
Belo Horizonte 25
Denver 25
Warsaw 25
Montreal 24
Tashkent 24
Johannesburg 23
Mexico City 23
Campinas 22
Dearborn 22
Guangzhou 22
Phoenix 21
Poplar 21
Augusta 20
Fragagnano 20
Manchester 20
Boston 19
Curitiba 19
Florence 19
Nuremberg 19
Boydton 18
Falkenstein 18
Pune 18
Wuhan 18
Lahore 17
Quito 17
Brasília 16
Guayaquil 16
San Mateo 16
Shanghai 16
Totale 17.120
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 235
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 208
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 208
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 206
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 198
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 192
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 189
Activation and inhibition of kidney CLC-K chloride channels by fenamates 186
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 185
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 170
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 167
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 165
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 163
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 162
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 161
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 161
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 159
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 158
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 158
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 156
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 156
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 154
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 154
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 154
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 153
Le applicazioni della chimica farmaceutica 152
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 152
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 151
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 149
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 148
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 146
Facile entry to (-)-R- and (+)-(S)-mexiletine 144
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 140
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 140
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 139
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 138
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 137
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 135
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 134
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 133
Structural development studies of PPARs ligands based on tyrosine scaffold. 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 132
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 131
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 131
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 130
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 130
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 129
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 129
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 128
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 128
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 128
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 126
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 126
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 126
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 125
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 124
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 123
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 123
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 123
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 122
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 122
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 121
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 121
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 121
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 120
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 119
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 119
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 118
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 118
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 117
Mimic catechins to develop selective MMP-2 inhibitors 117
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 117
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 115
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 115
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 115
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 115
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 114
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 114
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 113
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 113
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 111
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 109
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 109
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 108
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 107
Resveratrol and Its Metabolites Bind to PPARs 107
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 107
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 106
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents 106
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 104
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 104
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 104
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 103
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 103
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 102
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 102
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 101
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 100
Totale 13.547
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Categoria #
all - tutte 115.938
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 115.938
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.726 72 283 22 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/20254.033 183 88 398 153 103 271 338 370 180 232 506 1.211
2025/20269.037 1.109 466 606 1.073 877 453 1.018 280 774 897 305 1.179
2026/2027215 215 0 0 0 0 0 0 0 0 0 0 0
Totale 26.849