IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 9.947
EU - Europa 2.377
AS - Asia 1.281
OC - Oceania 10
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 5
AF - Africa 2
Totale 13.629
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Nazione #
US - Stati Uniti d'America 9.931
CN - Cina 891
SE - Svezia 593
UA - Ucraina 436
IT - Italia 344
DE - Germania 326
SG - Singapore 265
FI - Finlandia 241
GB - Regno Unito 171
FR - Francia 144
IN - India 44
BE - Belgio 38
IE - Irlanda 37
VN - Vietnam 28
IR - Iran 20
CA - Canada 14
AU - Australia 9
PT - Portogallo 9
CH - Svizzera 7
CZ - Repubblica Ceca 5
EU - Europa 5
JP - Giappone 5
AT - Austria 4
ES - Italia 4
HK - Hong Kong 4
NL - Olanda 4
RU - Federazione Russa 4
DK - Danimarca 3
ID - Indonesia 3
KR - Corea 3
MY - Malesia 3
TH - Thailandia 3
TR - Turchia 3
TW - Taiwan 3
A1 - Anonimo 2
AR - Argentina 2
BD - Bangladesh 2
CL - Cile 2
EG - Egitto 2
PL - Polonia 2
BG - Bulgaria 1
BR - Brasile 1
EE - Estonia 1
GE - Georgia 1
HN - Honduras 1
IL - Israele 1
KZ - Kazakistan 1
MT - Malta 1
MX - Messico 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
RO - Romania 1
Totale 13.629
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Città #
Fairfield 1.151
Chandler 1.058
Jacksonville 993
Woodbridge 810
Ashburn 682
Houston 582
Cambridge 524
Nyköping 468
Seattle 464
Ann Arbor 382
Wilmington 378
Lawrence 261
Roxbury 259
Nanjing 225
Singapore 202
Princeton 181
Boardman 150
Des Moines 150
New York 146
Beijing 134
Bari 125
Inglewood 113
Nanchang 66
Jiaxing 58
Hebei 55
San Diego 54
Santa Clara 47
Shenyang 46
Los Angeles 40
Brooklyn 38
Brussels 38
Dublin 37
Tianjin 33
Marseille 30
Changsha 29
Washington 29
Paris 28
Dong Ket 27
London 27
Leawood 26
Milan 23
Dearborn 22
Augusta 20
Guangzhou 20
Helsinki 20
Wuhan 18
San Mateo 16
Boydton 14
Toronto 14
Ardabil 13
Munich 13
Pune 13
Redwood City 13
Shanghai 13
Jinan 12
San Francisco 12
Kilburn 11
Norwalk 11
Wuxi 11
Auburn Hills 10
Genova 9
Lisbon 9
Monmouth Junction 9
Naples 9
Falls Church 8
Frankfurt am Main 8
Haikou 8
Islington 8
Jinhua 8
Ningbo 8
Zhengzhou 8
Shenzhen 7
Bitonto 6
Hefei 6
Hounslow 6
Prescot 6
Salerno 6
Brindisi 5
Brno 5
Chiswick 5
Patna 5
Taizhou 5
Edinburgh 4
Hangzhou 4
Indiana 4
Melbourne 4
Quanzhou 4
Rome 4
Sannicandro di Bari 4
Taranto 4
Vienna 4
Zurich 4
Aarhus 3
Brahmapur 3
Caserta 3
Chongqing 3
Cleveland 3
Florence 3
Heze 3
Kiev 3
Totale 10.663
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 159
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 135
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 130
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 127
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 124
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 119
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 117
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 115
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 113
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 112
Activation and inhibition of kidney CLC-K chloride channels by fenamates 112
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 112
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 111
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 108
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 102
Facile entry to (-)-R- and (+)-(S)-mexiletine 101
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 100
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 100
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 99
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 99
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 99
Structural development studies of PPARs ligands based on tyrosine scaffold. 98
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 98
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 97
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 97
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 97
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 93
Le applicazioni della chimica farmaceutica 93
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 93
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 93
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 92
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 92
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 90
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 90
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 90
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 89
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 88
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 87
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 87
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 86
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 85
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 85
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 84
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 83
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 83
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 82
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 82
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 81
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 80
Resveratrol and Its Metabolites Bind to PPARs 80
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 79
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 78
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 78
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 78
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 78
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 77
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 75
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 74
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 74
Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods 74
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 74
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 72
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 71
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 70
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 68
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 68
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 68
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 67
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 67
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 66
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 66
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 66
ANTAGONISM OF HUMAN PLATELET FUNCTIONAL SITES BY PHENOXY- AND THIOPHENOXYACETIC ACID ENANTIOMERS. 65
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 65
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 65
Differentbehavior toward racemization in basic media from chiral analogs of clofibric acid, the active metabolite of the antilipidemic drug clofibrate 65
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 65
Mimic catechins to develop selective MMP-2 inhibitors 65
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 65
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 64
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 63
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 63
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 62
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 61
Lipases for biocatalysis: development of a chromatographic bioreactor 60
Direct resolution of a-monoalkyl-a-aryloxyacetic acids via ester or imide derivatives 60
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 59
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 59
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 58
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 58
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 57
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 56
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 56
null 56
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 54
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 53
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 53
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 53
ATP-DEPENDENT EFFECTS OF CROMAKALIM AND OF NEW SYNTHESIZED BENZOXAZINE DERIVATIVES ON MUSCLE KATP CHANNEL. 52
Totale 8.252
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Categoria #
all - tutte 62.999
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 62.999
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.380 0 0 84 211 320 165 377 234 391 200 319 79
2020/20212.323 355 94 162 220 203 42 183 104 216 358 245 141
2021/20221.726 72 283 22 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/2025647 183 88 376 0 0 0 0 0 0 0 0 0
Totale 14.211