IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 12.763
AS - Asia 5.831
EU - Europa 3.953
SA - Sud America 1.583
AF - Africa 217
OC - Oceania 15
Continente sconosciuto - Info sul continente non disponibili 9
Totale 24.371
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Nazione #
US - Stati Uniti d'America 12.577
SG - Singapore 2.355
CN - Cina 1.405
BR - Brasile 1.257
HK - Hong Kong 743
SE - Svezia 606
IT - Italia 540
RU - Federazione Russa 499
DE - Germania 473
UA - Ucraina 458
FR - Francia 425
VN - Vietnam 382
FI - Finlandia 342
GB - Regno Unito 304
IN - India 226
BD - Bangladesh 112
AR - Argentina 103
CA - Canada 89
ID - Indonesia 72
IQ - Iraq 69
TR - Turchia 63
MX - Messico 55
EC - Ecuador 52
PK - Pakistan 50
BE - Belgio 48
AT - Austria 47
JP - Giappone 46
CI - Costa d'Avorio 45
CO - Colombia 44
IE - Irlanda 44
VE - Venezuela 40
ZA - Sudafrica 40
PH - Filippine 36
PL - Polonia 36
MA - Marocco 32
SA - Arabia Saudita 32
ES - Italia 29
MY - Malesia 27
UZ - Uzbekistan 25
CL - Cile 22
NL - Olanda 22
IR - Iran 21
PE - Perù 20
JO - Giordania 19
KE - Kenya 19
PY - Paraguay 19
EG - Egitto 18
TW - Taiwan 17
KR - Corea 15
TN - Tunisia 15
AU - Australia 13
AE - Emirati Arabi Uniti 12
LT - Lituania 12
NP - Nepal 12
UY - Uruguay 12
BO - Bolivia 11
AL - Albania 10
CH - Svizzera 10
OM - Oman 10
PT - Portogallo 10
AZ - Azerbaigian 9
CZ - Repubblica Ceca 8
DZ - Algeria 8
ET - Etiopia 8
LB - Libano 8
BH - Bahrain 7
KG - Kirghizistan 7
KZ - Kazakistan 7
DK - Danimarca 6
IL - Israele 6
JM - Giamaica 6
EU - Europa 5
GE - Georgia 5
PA - Panama 5
AO - Angola 4
CR - Costa Rica 4
HN - Honduras 4
LY - Libia 4
PS - Palestinian Territory 4
SN - Senegal 4
SY - Repubblica araba siriana 4
TH - Thailandia 4
TT - Trinidad e Tobago 4
BB - Barbados 3
BN - Brunei Darussalam 3
DO - Repubblica Dominicana 3
GA - Gabon 3
HU - Ungheria 3
KW - Kuwait 3
NI - Nicaragua 3
RS - Serbia 3
TJ - Tagikistan 3
ZW - Zimbabwe 3
A1 - Anonimo 2
AD - Andorra 2
AM - Armenia 2
BG - Bulgaria 2
EE - Estonia 2
GD - Grenada 2
GM - Gambi 2
Totale 24.322
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Città #
Ashburn 1.212
Singapore 1.183
Fairfield 1.151
Chandler 1.058
Jacksonville 993
Woodbridge 811
Hong Kong 726
San Jose 627
Houston 599
Cambridge 524
Seattle 474
Nyköping 468
Ann Arbor 382
Wilmington 379
Beijing 334
Lawrence 261
Roxbury 259
Lauterbourg 237
Nanjing 227
Dallas 209
New York 196
Princeton 181
Los Angeles 166
Ho Chi Minh City 152
Boardman 151
Des Moines 150
Bari 140
Inglewood 113
Helsinki 112
São Paulo 94
Santa Clara 90
Council Bluffs 87
Hanoi 77
Nanchang 66
Brooklyn 64
Munich 61
Jiaxing 58
Hebei 55
San Diego 55
London 54
Buffalo 52
Chicago 52
Frankfurt am Main 51
Brussels 47
Shenyang 47
Abidjan 45
Dublin 44
Jakarta 43
Tokyo 41
Moscow 38
Naples 36
Rio de Janeiro 36
Baghdad 35
Chennai 35
Tianjin 35
Orem 34
Changsha 33
Marseille 31
San Francisco 31
Washington 31
Paris 30
Toronto 30
Atlanta 28
Dong Ket 27
Leawood 26
Milan 26
Belo Horizonte 25
North Bergen 25
Warsaw 25
Denver 24
Tashkent 24
Johannesburg 23
Campinas 22
Dearborn 22
Guangzhou 22
Montreal 21
Poplar 21
Augusta 20
Fragagnano 20
Manchester 20
Boston 19
Curitiba 19
Nuremberg 19
Phoenix 19
Falkenstein 18
Mexico City 18
Pune 18
Wuhan 18
Lahore 17
Rome 17
Brasília 16
Guayaquil 16
Quito 16
San Mateo 16
Shanghai 16
Vienna 16
Boydton 15
Caracas 15
Dhaka 15
Istanbul 15
Totale 15.852
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 223
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 204
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 203
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 191
Activation and inhibition of kidney CLC-K chloride channels by fenamates 184
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 181
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 180
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 180
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 180
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 164
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 157
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 156
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 154
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 153
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 152
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 152
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 151
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 151
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 151
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 148
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 147
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 146
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 146
Le applicazioni della chimica farmaceutica 145
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 144
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 144
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 142
Facile entry to (-)-R- and (+)-(S)-mexiletine 142
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 140
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 139
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 137
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 137
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 137
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 136
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 136
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 134
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 133
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 130
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 130
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 128
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 127
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 126
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 125
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 125
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 124
Structural development studies of PPARs ligands based on tyrosine scaffold. 122
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 122
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 122
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 121
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 121
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 120
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 120
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 120
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 120
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 119
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 119
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 118
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 118
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 118
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 118
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 117
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 117
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 117
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 115
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 114
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 114
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 114
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 111
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 110
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 110
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 110
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects 110
Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase 109
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 109
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 108
Mimic catechins to develop selective MMP-2 inhibitors 108
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 107
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 107
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 107
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 106
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 106
Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases 105
Resveratrol and Its Metabolites Bind to PPARs 104
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 104
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 102
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 102
Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect 102
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 101
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 101
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition 100
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 98
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 98
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 98
ATP-DEPENDENT EFFECTS OF CROMAKALIM AND OF NEW SYNTHESIZED BENZOXAZINE DERIVATIVES ON MUSCLE KATP CHANNEL. 97
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 96
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 95
Synthesis and Biological Evaluation of Pyrazoline and Pyrrolidine-2,5-dione Hybrids as Potential Antitumor Agents 95
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 94
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 94
Direct resolution of a-monoalkyl-a-aryloxyacetic acids via ester or imide derivatives 94
Totale 12.819
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Categoria #
all - tutte 106.455
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 106.455
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021744 0 0 0 0 0 0 0 0 0 358 245 141
2021/20221.726 72 283 22 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/20254.033 183 88 398 153 103 271 338 370 180 232 506 1.211
2025/20267.427 1.109 466 606 1.073 877 453 1.018 280 774 771 0 0
Totale 25.024