Distribuzione geografica
Continente #
NA - Nord America 9.115
EU - Europa 2.262
AS - Asia 764
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 7
SA - Sud America 4
Totale 12.161
Nazione #
US - Stati Uniti d'America 9.100
CN - Cina 675
SE - Svezia 581
UA - Ucraina 428
DE - Germania 297
IT - Italia 255
FI - Finlandia 229
GB - Regno Unito 143
FR - Francia 141
BE - Belgio 105
IE - Irlanda 44
VN - Vietnam 28
IR - Iran 20
IN - India 18
CA - Canada 13
PT - Portogallo 9
AU - Australia 8
CH - Svizzera 5
EU - Europa 5
JP - Giappone 5
AT - Austria 4
NL - Olanda 4
RU - Federazione Russa 4
DK - Danimarca 3
ID - Indonesia 3
TR - Turchia 3
A1 - Anonimo 2
AR - Argentina 2
BD - Bangladesh 2
CL - Cile 2
ES - Italia 2
PL - Polonia 2
TW - Taiwan 2
BG - Bulgaria 1
CZ - Repubblica Ceca 1
EE - Estonia 1
GE - Georgia 1
HK - Hong Kong 1
HN - Honduras 1
IL - Israele 1
KR - Corea 1
KZ - Kazakistan 1
MT - Malta 1
MX - Messico 1
NO - Norvegia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
RO - Romania 1
SG - Singapore 1
TH - Thailandia 1
Totale 12.161
Città #
Fairfield 1.148
Chandler 1.049
Jacksonville 976
Woodbridge 798
Houston 559
Cambridge 515
Nyköping 459
Seattle 451
Ashburn 432
Ann Arbor 382
Wilmington 376
Lawrence 259
Roxbury 256
Nanjing 221
Princeton 181
Des Moines 150
Boardman 124
Bari 115
Beijing 115
Inglewood 112
Brussels 105
Nanchang 65
Hebei 55
San Diego 54
Jiaxing 48
Shenyang 46
Dublin 44
Brooklyn 37
Tianjin 33
Changsha 28
Paris 28
Dong Ket 27
Marseille 27
Leawood 26
Dearborn 22
London 22
Augusta 20
San Mateo 16
Boydton 14
Ardabil 13
Milan 13
Toronto 13
Redwood City 12
Helsinki 11
Auburn Hills 10
Islington 10
Jinan 10
San Francisco 10
Genova 9
Lisbon 9
Monmouth Junction 9
Norwalk 9
Falls Church 8
Ningbo 8
Chiswick 7
Haikou 7
Zhengzhou 7
Hefei 6
Los Angeles 6
Edinburgh 4
Indiana 4
Melbourne 4
New York 4
Rome 4
Taizhou 4
Taranto 4
Vienna 4
Zurich 4
Aarhus 3
Caserta 3
Guangzhou 3
Hangzhou 3
Kiev 3
Kunming 3
Nürnberg 3
Yellow Springs 3
Amsterdam 2
Barletta 2
Campobello Di Mazara 2
Canberra 2
Cassano Magnago 2
Chicago 2
Chieti 2
Chongqing 2
Easton 2
Fossalta di Piave 2
Kansas City 2
Latina 2
Madrid 2
Molfetta 2
Naples 2
Napoli 2
Palagiano 2
Redmond 2
Salerno 2
Simi Valley 2
Sydney 2
Taipei 2
Tampa 2
Tappahannock 2
Totale 9.690
Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 149
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 126
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 124
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 118
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 114
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 110
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 109
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 106
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 106
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 104
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 104
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 104
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 102
Activation and inhibition of kidney CLC-K chloride channels by fenamates 100
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 97
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 96
Structural development studies of PPARs ligands based on tyrosine scaffold. 95
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 94
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 94
Facile entry to (-)-R- and (+)-(S)-mexiletine 92
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 92
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 91
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 91
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 91
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 90
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 89
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 89
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 89
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 87
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 87
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 87
Le applicazioni della chimica farmaceutica 86
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 86
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 86
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 85
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 83
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 81
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 81
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 80
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 80
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 79
Resveratrol and Its Metabolites Bind to PPARs 79
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 79
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 79
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 79
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 79
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 78
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 77
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 76
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 75
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 75
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 74
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 73
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 72
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 71
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 71
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 71
Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods 70
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 70
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 66
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 64
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 64
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 64
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 63
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 63
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 63
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 63
Mimic catechins to develop selective MMP-2 inhibitors 62
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 61
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 61
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 60
Differentbehavior toward racemization in basic media from chiral analogs of clofibric acid, the active metabolite of the antilipidemic drug clofibrate 59
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 59
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 58
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 58
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 58
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 57
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 57
Direct resolution of a-monoalkyl-a-aryloxyacetic acids via ester or imide derivatives 56
null 56
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 55
Lipases for biocatalysis: development of a chromatographic bioreactor 55
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 53
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 53
Natural compounds as FAAH inhibitors: preliminary screening and potential developments 53
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 51
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 51
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 51
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 48
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 48
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 48
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 47
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 46
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 46
Totale 7.626
Categoria #
all - tutte 38.613
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.613

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/20191.032 0 0 14 5 51 164 32 10 6 146 292 312
2019/20203.204 646 204 83 208 316 163 373 232 387 199 315 78
2020/20212.319 352 93 160 219 198 42 190 103 218 355 248 141
2021/20221.707 72 279 22 67 54 78 75 75 96 75 299 515
2022/20232.930 495 210 158 250 379 383 39 320 513 57 74 52
2023/2024301 89 182 30 0 0 0 0 0 0 0 0 0
Totale 12.708