IRIS
LOIODICE, Fulvio
 Distribuzione geografica
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Continente #
NA - Nord America 11.599
AS - Asia 4.766
EU - Europa 3.407
SA - Sud America 1.325
AF - Africa 124
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 8
Totale 21.242
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Nazione #
US - Stati Uniti d'America 11.455
SG - Singapore 2.039
CN - Cina 1.252
BR - Brasile 1.146
HK - Hong Kong 702
SE - Svezia 605
RU - Federazione Russa 489
UA - Ucraina 452
IT - Italia 441
DE - Germania 436
VN - Vietnam 307
FI - Finlandia 267
GB - Regno Unito 266
FR - Francia 186
IN - India 118
CA - Canada 71
AR - Argentina 65
ID - Indonesia 60
BD - Bangladesh 51
AT - Austria 47
BE - Belgio 47
CI - Costa d'Avorio 44
MX - Messico 42
IE - Irlanda 41
EC - Ecuador 32
TR - Turchia 31
IQ - Iraq 30
JP - Giappone 30
PL - Polonia 26
ES - Italia 24
ZA - Sudafrica 22
IR - Iran 21
CO - Colombia 20
VE - Venezuela 16
NL - Olanda 15
PE - Perù 15
SA - Arabia Saudita 15
PY - Paraguay 14
EG - Egitto 12
MA - Marocco 12
PK - Pakistan 12
AU - Australia 11
CH - Svizzera 10
KR - Corea 10
PT - Portogallo 10
UZ - Uzbekistan 10
CL - Cile 9
LT - Lituania 9
TW - Taiwan 9
KE - Kenya 8
CZ - Repubblica Ceca 6
DK - Danimarca 6
JO - Giordania 6
TN - Tunisia 6
AE - Emirati Arabi Uniti 5
AL - Albania 5
AZ - Azerbaigian 5
EU - Europa 5
JM - Giamaica 5
KZ - Kazakistan 5
MY - Malesia 5
NP - Nepal 5
PH - Filippine 5
UY - Uruguay 5
HN - Honduras 4
IL - Israele 4
TT - Trinidad e Tobago 4
BB - Barbados 3
DZ - Algeria 3
GA - Gabon 3
GE - Georgia 3
OM - Oman 3
PA - Panama 3
PS - Palestinian Territory 3
RS - Serbia 3
TH - Thailandia 3
A1 - Anonimo 2
AD - Andorra 2
AO - Angola 2
BH - Bahrain 2
BN - Brunei Darussalam 2
BO - Bolivia 2
CR - Costa Rica 2
EE - Estonia 2
GD - Grenada 2
GT - Guatemala 2
KG - Kirghizistan 2
MN - Mongolia 2
NO - Norvegia 2
RO - Romania 2
SN - Senegal 2
AF - Afghanistan, Repubblica islamica di 1
AM - Armenia 1
BG - Bulgaria 1
BW - Botswana 1
CG - Congo 1
CV - Capo Verde 1
DO - Repubblica Dominicana 1
GM - Gambi 1
GP - Guadalupe 1
Totale 21.214
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Città #
Fairfield 1.151
Chandler 1.058
Ashburn 1.051
Jacksonville 993
Singapore 960
Woodbridge 811
Hong Kong 694
Houston 596
Cambridge 524
Seattle 474
Nyköping 468
Ann Arbor 382
Wilmington 379
Beijing 327
Lawrence 261
Roxbury 259
Nanjing 227
Dallas 205
New York 185
Princeton 181
Los Angeles 155
Boardman 151
Des Moines 150
Bari 140
Ho Chi Minh City 126
Inglewood 113
São Paulo 86
Santa Clara 70
Nanchang 66
Brooklyn 63
Munich 61
Jiaxing 58
Hanoi 57
Hebei 55
San Diego 54
Buffalo 52
London 51
Chicago 48
Brussels 46
Shenyang 46
Abidjan 44
Jakarta 41
Dublin 40
Council Bluffs 38
Moscow 38
Helsinki 37
Tianjin 35
Frankfurt am Main 34
Changsha 33
Rio de Janeiro 33
Washington 31
Marseille 30
Naples 30
San Francisco 29
Paris 28
Dong Ket 27
Tokyo 27
Leawood 26
Milan 25
North Bergen 25
Belo Horizonte 24
Toronto 24
Chennai 23
Dearborn 22
Guangzhou 21
Augusta 20
Campinas 20
Fragagnano 20
Atlanta 19
Pune 18
Warsaw 18
Wuhan 18
Curitiba 17
Nuremberg 17
Baghdad 16
Johannesburg 16
Montreal 16
San Mateo 16
Vienna 16
Boydton 15
Phoenix 15
Poplar 15
Shanghai 15
Langenzersdorf 14
Manchester 14
Ardabil 13
Boston 13
Brasília 13
Denver 13
Porto Alegre 13
Redwood City 13
Stockholm 13
Jinan 12
Mexico City 12
Norwalk 12
Redondo Beach 12
The Dalles 12
Wuxi 12
Columbus 11
Kilburn 11
Totale 14.119
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Nome #
Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity 213
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 190
New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity 190
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 171
Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin 169
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 167
Activation and inhibition of kidney CLC-K chloride channels by fenamates 165
On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles 161
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 144
A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders 142
6-Chloro-2,3-dihydro-4H-1-benzopyran carboxylic acids: synthesis, optical resolution and absolute configuration 141
Comparative LC Enantioseparation of Novel PPAR Agonists on Cellulose- and Amylose-Based Chiral Stationary Phases 140
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 140
Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists 140
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 139
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 137
Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors 136
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands 134
An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors 134
Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy 133
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation 132
Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors 131
Effects of clofibric acid analogs on chloride channel conductance of rat skeletal muscle 130
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 129
Le applicazioni della chimica farmaceutica 128
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome. 127
Facile entry to (-)-R- and (+)-(S)-mexiletine 126
Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers 125
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 123
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 122
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 121
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors 121
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 120
DEVELOPMENT OF PHENOXYALKYLPIPERIDINES AS HIGH-AFFINITY SIGMA-1 (s1) RECEPTOR LIGANDS WITH POTENT ANTI-AMNESIC ACTIVITY 119
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 118
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease 118
Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode 118
Chiral a-substituted a-aryloxy acetic acids: synthesis, absolute configuration, chemical resolution and direct separation by HPLC 116
Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme 116
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 114
Structural development studies of PPARs ligands based on tyrosine scaffold. 114
Carboxylic acids and chloride conductance in skeletal muscle: influence on the pharmacological activity induced by the chain substituents and the distance between the phenolic group and the carboxylic function in 4-chloro-phenoxy alkanoic acids 114
Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment 114
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 113
Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization 112
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 112
Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity 111
A new benzoxazine compound blocks KATP channels in pancreatic beta cells: molecular basis for tissue selectivity in vitro and hypoglycaemic action in vivo 110
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 109
Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin 109
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 108
Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents 108
Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines 107
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 106
Structural basis of the transactivation deficiency of human PPARγ F360L mutant associated with familial partial lipodystrophy 106
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 106
The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs 106
Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study 105
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 105
(2-Aminobenzothiazole)-Methyl-1,1-bisphosphonic acids: Targeting matrix metalloproteinase 13 inhibition to the bone 105
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 104
Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents 103
Biphenyl sulfonylamino methyl bisphosphonic acids as inhibitors of matrix metalloproteinases and bone resorption 102
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 101
Arylamino bisphosphonates: potent and selective inhibitors of the tumor-associated carbonic anhydrase XII 101
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 98
Dualistic actions of cromakalim and new potent 2H-1,4-benzoxazine derivatives on the native skeletal muscle K(ATP) channel 97
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 97
Resveratrol and Its Metabolites Bind to PPARs 96
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 96
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 96
Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids 96
Structural requirements of chiral clofibric acid analogs for activation of the rat peroxisome proliferator-activated receptor a 96
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 96
A Chemoinformatics Search for Peroxisome Proliferator-Activated Receptors Ligands Revealed a New Pan-Agonist Able to Reduce Lipid Accumulation and Improve Insulin Sensitivity 96
Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation 95
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors 94
Mimic catechins to develop selective MMP-2 inhibitors 94
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 94
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 92
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 91
Identification of novel matrix metalloproteinase inhibitors by screening of phenol fragments library 91
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 91
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 90
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 87
Direct resolution of a-monoalkyl-a-aryloxyacetic acids via ester or imide derivatives 87
Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes 86
Effects of biphenyl sulfonylamino methyl bisphosphonic acids on Porphyromonas Gingivalis and cytokine secretion by oral epithelial cells 86
Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods 86
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 85
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 84
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 84
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 84
A NEW ANTIDIABETIC AGENT SHOWING PPARα/γ DUAL AGONISM AND MITOCHONDRIAL PYRUVATE CARRIER INHIBITION 83
3D STRUCTURE AND BIOLOGICAL ACTIVITY OF NOVEL DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS ALPHA/GAMMA LIGANDS. 83
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 83
A Chemical Modification of a Peroxisome Proliferator-Activated Receptor Pan Agonist Produced a Shift to a New Dual Alpha/Gamma Partial Agonist Endowed with Mitochondrial Pyruvate Carrier Inhibition and Antidiabetic Properties 82
ATP-DEPENDENT EFFECTS OF CROMAKALIM AND OF NEW SYNTHESIZED BENZOXAZINE DERIVATIVES ON MUSCLE KATP CHANNEL. 82
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 82
Totale 11.409
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Categoria #
all - tutte 100.002
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 100.002
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.289 0 0 0 0 0 42 183 104 216 358 245 141
2021/20221.726 72 283 22 67 56 77 79 77 94 73 301 525
2022/20232.894 498 213 160 252 388 386 28 322 509 21 69 48
2023/20241.086 85 181 56 75 115 277 46 65 22 30 30 104
2024/20254.033 183 88 398 153 103 271 338 370 180 232 506 1.211
2025/20264.296 1.109 466 606 1.073 877 165 0 0 0 0 0 0
Totale 21.893