| Nome |
# |
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Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II, file dd9e0c67-c9bf-1e9c-e053-3a05fe0a45ef
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161
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Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the treatment of Alzheimer’s disease, file dd9e0c67-3027-1e9c-e053-3a05fe0a45ef
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145
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Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARgamma Agonists and their Antidiabetic Effects on Type 2 Diabetes, file dd9e0c66-8f8a-1e9c-e053-3a05fe0a45ef
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97
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Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease, file dd9e0c66-8dc6-1e9c-e053-3a05fe0a45ef
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90
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Chiral phenoxyacetic acid analogues inhibit colon cancer cell proliferation acting as PPARγ partial agonists, file dd9e0c66-8db2-1e9c-e053-3a05fe0a45ef
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83
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Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis, file dd9e0c64-85f8-1e9c-e053-3a05fe0a45ef
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77
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Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity, file dd9e0c66-8f8e-1e9c-e053-3a05fe0a45ef
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77
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Selective inhibition of matrix metalloproteinase-2 in the multiple myeloma-bone microenvironment, file dd9e0c64-814b-1e9c-e053-3a05fe0a45ef
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74
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Importance of Biometals as Targets in Medicinal Chemistry: An Overview about the Role of Zinc (II) Chelating Agents, file dd9e0c68-5c34-1e9c-e053-3a05fe0a45ef
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70
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Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode, file dd9e0c63-bb13-1e9c-e053-3a05fe0a45ef
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69
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Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study, file dd9e0c66-8dca-1e9c-e053-3a05fe0a45ef
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61
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Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy, file dd9e0c68-4fa9-1e9c-e053-3a05fe0a45ef
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61
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Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin, file dd9e0c63-e8eb-1e9c-e053-3a05fe0a45ef
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55
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Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation, file dd9e0c6c-871b-1e9c-e053-3a05fe0a45ef
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47
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Antiproliferative activity evaluation of a series of N-1,3-benzothiazol-2-ylbenzamides as novel apoptosis inducers, file dd9e0c63-e8ee-1e9c-e053-3a05fe0a45ef
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42
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New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity, file dd9e0c6c-8293-1e9c-e053-3a05fe0a45ef
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42
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Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin, file 532a9616-86bc-4c73-a539-5e57ac807860
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38
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Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrides by chiral N-(biarylsulfonyl)-phosphonic acids., file dd9e0c66-6835-1e9c-e053-3a05fe0a45ef
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32
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On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles, file dd9e0c6c-8d86-1e9c-e053-3a05fe0a45ef
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27
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Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome., file 06729c17-d60a-4dee-a0be-40abecb054f4
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16
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Statin-induced myotoxicity is exacerbated by aging: A biophysical and molecular biology study in rats treated with atorvastatin, file dd9e0c63-82b7-1e9c-e053-3a05fe0a45ef
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13
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Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels, file dd9e0c66-4f31-1e9c-e053-3a05fe0a45ef
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10
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Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs., file dd9e0c64-b03e-1e9c-e053-3a05fe0a45ef
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7
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Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines, file dd9e0c66-8bee-1e9c-e053-3a05fe0a45ef
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7
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In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension?, file dd9e0c68-d478-1e9c-e053-3a05fe0a45ef
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7
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Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme, file dd9e0c63-b145-1e9c-e053-3a05fe0a45ef
|
6
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|
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome., file dd9e0c66-8db4-1e9c-e053-3a05fe0a45ef
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6
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A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders, file dd9e0c68-60ff-1e9c-e053-3a05fe0a45ef
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5
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Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation, file dd9e0c66-8dcd-1e9c-e053-3a05fe0a45ef
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4
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Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors, file dd9e0c68-b3f1-1e9c-e053-3a05fe0a45ef
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4
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An Effective Virtual Screening Protocol to Identify Promising p53-MDM2 Inhibitors, file dd9e0c63-b322-1e9c-e053-3a05fe0a45ef
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3
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|
An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands, file dd9e0c66-8db0-1e9c-e053-3a05fe0a45ef
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3
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New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity, file dd9e0c66-8f88-1e9c-e053-3a05fe0a45ef
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3
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|
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175, file dd9e0c66-c39d-1e9c-e053-3a05fe0a45ef
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3
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Metal chelators for the multi-target therapy of Alzheimer's Disease: isolation/synthesis and preliminary biological evaluation of new natural and synthetic compounds., file dd9e0c68-3521-1e9c-e053-3a05fe0a45ef
|
3
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|
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors, file dd9e0c68-6100-1e9c-e053-3a05fe0a45ef
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3
|
|
Natural compounds as FAAH inhibitors: preliminary screening and potential developments, file dd9e0c68-766e-1e9c-e053-3a05fe0a45ef
|
3
|
|
Selective MMP inhibitors for the treatment of skeletal malignancy., file dd9e0c68-96da-1e9c-e053-3a05fe0a45ef
|
3
|
|
New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation, file dd9e0c6c-7624-1e9c-e053-3a05fe0a45ef
|
3
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New rivastigmine-like compounds for the potential treatment of Alzheimer’s disease: a multi-target approach, file 5e6a9492-6c70-4709-81bc-1ed2ff532a07
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2
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Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1, file dd9e0c63-a198-1e9c-e053-3a05fe0a45ef
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2
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On the metabolically active form of metaglidasen: improved synthesis and investigation of its peculiar activity on peroxisome proliferator-activated receptors and skeletal muscles, file dd9e0c66-6838-1e9c-e053-3a05fe0a45ef
|
2
|
|
Mimic catechins to develop selective MMP-2 inhibitors, file dd9e0c66-8dc8-1e9c-e053-3a05fe0a45ef
|
2
|
|
Structural development studies of PPARs ligands based on tyrosine scaffold., file dd9e0c66-c39f-1e9c-e053-3a05fe0a45ef
|
2
|
|
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease, file dd9e0c68-504e-1e9c-e053-3a05fe0a45ef
|
2
|
|
Novel small molecules for PPARs modulation and their potential use for treatment of metabolic disorders, file dd9e0c68-766a-1e9c-e053-3a05fe0a45ef
|
2
|
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Synthesis and biological activity evaluation of novel diphenylmethane-based ligands for PPARα and PPARγ, file dd9e0c68-772a-1e9c-e053-3a05fe0a45ef
|
2
|
|
Multi-Target Approach for the Design of New Compounds Potentially Useful for the Prevention and Treatment of Cardiovascular and/or Neurodegenerative Diseases, file dd9e0c6b-7123-1e9c-e053-3a05fe0a45ef
|
2
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Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases, file dd9e0c6b-744c-1e9c-e053-3a05fe0a45ef
|
2
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Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease, file dd9e0c6c-30c6-1e9c-e053-3a05fe0a45ef
|
2
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Nature-inspired structures for the multi-target treatment of Alzheimer’s disease: a successful approach for drug design, file edc18531-dc8c-4ec3-8866-430d97067a01
|
2
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Rivastigmine-based hybrids: a multi-target approach to anti-Alzheimer’s drug design, file 0202e201-85c2-4cc9-b4fc-987e2dd8682d
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1
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Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease, file 0d9474da-8d60-447e-aa67-026b5e9ea1bd
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1
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Structural insight into the crucial role of ligand chirality in the activation of PPARs by crystallographic methods, file dd9e0c62-5e87-1e9c-e053-3a05fe0a45ef
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1
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Lipase-mediated kinetic resolution of rigid clofibrate analogues, with lipid-modifying activity, file dd9e0c63-3345-1e9c-e053-3a05fe0a45ef
|
1
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null, file dd9e0c63-a428-1e9c-e053-3a05fe0a45ef
|
1
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Facile entry to (-)-R- and (+)-(S)-mexiletine, file dd9e0c67-c643-1e9c-e053-3a05fe0a45ef
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1
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Natural scaffolds with potential metal chelating activity for the multi-target therapy of Alzheimer's Disease: a preliminary study, file dd9e0c68-2eb3-1e9c-e053-3a05fe0a45ef
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1
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The Therapy of Alzheimer’s Disease: Towards a New Generation of Drugs, file dd9e0c68-511d-1e9c-e053-3a05fe0a45ef
|
1
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|
Synthesis of N-acylsulfonilamides and amides as potential PPARalpha antagonists, file dd9e0c68-aec3-1e9c-e053-3a05fe0a45ef
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1
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Analytical approaches for the identification of new ligands of Peroxisome Proliferator-Activated Receptors: a complex journey., file dd9e0c68-aec6-1e9c-e053-3a05fe0a45ef
|
1
|
|
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects, file dd9e0c6b-3a3a-1e9c-e053-3a05fe0a45ef
|
1
|
|
Multiple causes, multiple targets: FAAH as a centerpiece for therapy of multifactorial pathologies., file dd9e0c6b-7519-1e9c-e053-3a05fe0a45ef
|
1
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|
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE), file dd9e0c6c-06fc-1e9c-e053-3a05fe0a45ef
|
1
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Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ1) receptor ligands with potent anti-amnesic effect, file dd9e0c6c-0700-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
1.498 |