IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 10.340
AS - Asia 4.699
EU - Europa 4.345
SA - Sud America 1.133
AF - Africa 191
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 6
AN - Antartide 2
Totale 20.722
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Nazione #
US - Stati Uniti d'America 10.126
SG - Singapore 1.810
IT - Italia 1.382
CN - Cina 1.205
BR - Brasile 914
SE - Svezia 596
DE - Germania 594
HK - Hong Kong 555
RU - Federazione Russa 537
VN - Vietnam 357
FR - Francia 288
GB - Regno Unito 254
FI - Finlandia 217
UA - Ucraina 189
IN - India 182
CA - Canada 102
BD - Bangladesh 92
ID - Indonesia 81
AR - Argentina 79
MX - Messico 65
TR - Turchia 52
JP - Giappone 47
NL - Olanda 46
IQ - Iraq 45
PL - Polonia 45
ZA - Sudafrica 41
BE - Belgio 39
CI - Costa d'Avorio 39
EC - Ecuador 35
MA - Marocco 35
PH - Filippine 35
IE - Irlanda 32
IR - Iran 31
CO - Colombia 28
PK - Pakistan 28
AT - Austria 27
ES - Italia 27
SA - Arabia Saudita 23
VE - Venezuela 23
EG - Egitto 17
CZ - Repubblica Ceca 16
TN - Tunisia 16
UZ - Uzbekistan 16
AE - Emirati Arabi Uniti 15
CL - Cile 15
CR - Costa Rica 15
LT - Lituania 15
MY - Malesia 15
PY - Paraguay 15
KE - Kenya 12
PE - Perù 12
CH - Svizzera 11
NP - Nepal 10
OM - Oman 10
TH - Thailandia 10
AZ - Azerbaigian 9
DZ - Algeria 9
JM - Giamaica 9
KR - Corea 9
JO - Giordania 8
KG - Kirghizistan 8
ET - Etiopia 7
IL - Israele 7
BO - Bolivia 6
RO - Romania 6
SY - Repubblica araba siriana 6
TW - Taiwan 6
KZ - Kazakistan 5
LB - Libano 5
AU - Australia 4
BY - Bielorussia 4
EU - Europa 4
NG - Nigeria 4
AL - Albania 3
AO - Angola 3
DO - Repubblica Dominicana 3
PA - Panama 3
RS - Serbia 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
UY - Uruguay 3
AM - Armenia 2
BB - Barbados 2
BH - Bahrain 2
GE - Georgia 2
GT - Guatemala 2
HN - Honduras 2
KW - Kuwait 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SO - Somalia 2
SR - Suriname 2
XK - ???statistics.table.value.countryCode.XK??? 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AQ - Antartide 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
BS - Bahamas 1
Totale 20.695
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Città #
Ashburn 1.051
Singapore 971
Fairfield 921
Chandler 762
San Jose 682
Woodbridge 544
Hong Kong 540
Milan 502
Nyköping 460
Jacksonville 413
Houston 403
Beijing 372
Seattle 372
Ann Arbor 347
Cambridge 330
Dallas 330
Wilmington 319
Bari 183
Lauterbourg 161
Boardman 155
Roxbury 149
Lawrence 145
New York 138
Nanjing 132
Los Angeles 130
Ho Chi Minh City 121
Rome 121
Council Bluffs 117
Helsinki 108
Dearborn 92
Des Moines 92
Brooklyn 83
São Paulo 82
Santa Clara 81
Munich 78
Princeton 71
Hanoi 69
Columbus 63
Falkenstein 63
Jakarta 59
North Bergen 53
Buffalo 51
Figino 51
San Diego 50
Moscow 45
Inglewood 44
Nanchang 43
Hebei 41
Atlanta 40
Chicago 40
Frankfurt am Main 40
Abidjan 39
Brussels 39
Tokyo 39
Montreal 37
London 36
Marseille 36
Shenyang 36
Jiaxing 35
Dublin 31
Guangzhou 29
Orem 29
Paris 29
Warsaw 29
Johannesburg 28
Nuremberg 28
Rio de Janeiro 28
Belo Horizonte 27
Turin 27
Chennai 26
Kansas City 25
Denver 24
San Francisco 24
Mexico City 22
Baghdad 21
Poplar 21
Redwood City 21
Shanghai 21
Tianjin 21
Naples 20
New Delhi 20
Toronto 19
Amsterdam 18
Phoenix 18
The Dalles 18
Haiphong 17
Augusta 16
Boston 16
Porto Alegre 16
Stockholm 16
Bologna 15
Brasília 15
Quito 15
Washington 15
Bitonto 14
Boydton 14
Dong Ket 14
Leawood 14
Tashkent 14
Wuhan 14
Totale 13.456
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Nome #
Applicability Domain for QSAR models: where theory meets reality 253
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 234
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 216
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 215
A rational approach to elucidate human monoamine oxidase molecular selectivity 214
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 209
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 201
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 199
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 198
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 196
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 195
Mind the Gap ! A Journey towards Computational Toxicology 194
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 193
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 190
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 189
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 189
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 189
Multitarget Drug Design for Neurodegenerative Diseases 187
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 183
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 179
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 179
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 178
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 178
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 172
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 171
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 166
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 165
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 165
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 164
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 161
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 161
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 160
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 148
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 148
A multitarget approach in cancer research 147
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 147
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 146
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 144
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 143
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 143
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 139
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 139
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 138
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 138
A Multi-Objective Optimization Algorithm for Molecular Design 138
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 137
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 137
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 136
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 135
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 133
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 131
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 127
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 127
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 127
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 125
Estimation of the Binding Free Energy by Linear Interaction Energy Models 125
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 124
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 122
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 122
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 121
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 120
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 120
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 119
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 116
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 115
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 115
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 114
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 114
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 113
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 113
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 112
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 112
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 112
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 111
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 111
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 110
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 110
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 109
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 108
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 108
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 106
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 106
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 105
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 104
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 103
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 103
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 102
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 102
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 102
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 101
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 101
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 101
Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases 101
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 100
Totale 14.426
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Categoria #
all - tutte 83.726
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 83.726
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.191 53 194 35 26 48 50 61 48 68 142 177 289
2022/20232.136 302 237 146 173 301 226 19 240 338 52 62 40
2023/2024875 58 122 44 129 59 161 39 25 35 33 18 152
2024/20253.353 131 90 237 144 129 256 378 295 171 142 486 894
2025/20268.001 979 394 652 838 865 432 899 279 795 663 325 880
2026/2027207 207 0 0 0 0 0 0 0 0 0 0 0
Totale 21.351