IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 6.829
EU - Europa 2.011
AS - Asia 932
AF - Africa 11
SA - Sud America 7
Continente sconosciuto - Info sul continente non disponibili 4
AN - Antartide 1
Totale 9.795
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Nazione #
US - Stati Uniti d'America 6.818
CN - Cina 687
SE - Svezia 583
DE - Germania 403
IT - Italia 390
UA - Ucraina 169
SG - Singapore 148
GB - Regno Unito 137
FI - Finlandia 112
FR - Francia 69
RU - Federazione Russa 49
IN - India 38
BE - Belgio 33
IE - Irlanda 27
IR - Iran 26
NL - Olanda 14
VN - Vietnam 14
CA - Canada 9
CZ - Repubblica Ceca 9
CH - Svizzera 5
EG - Egitto 4
EU - Europa 4
JP - Giappone 4
TR - Turchia 4
MA - Marocco 3
PL - Polonia 3
RO - Romania 3
BR - Brasile 2
DZ - Algeria 2
ES - Italia 2
MX - Messico 2
NG - Nigeria 2
PE - Perù 2
TH - Thailandia 2
AM - Armenia 1
AT - Austria 1
CL - Cile 1
CO - Colombia 1
EC - Ecuador 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HK - Hong Kong 1
ID - Indonesia 1
IL - Israele 1
IQ - Iraq 1
IS - Islanda 1
KR - Corea 1
NO - Norvegia 1
NP - Nepal 1
PH - Filippine 1
TW - Taiwan 1
Totale 9.795
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Città #
Fairfield 921
Chandler 765
Woodbridge 544
Ashburn 482
Nyköping 465
Jacksonville 411
Houston 390
Seattle 359
Ann Arbor 347
Cambridge 329
Wilmington 315
Bari 157
Roxbury 149
Lawrence 146
Nanjing 131
Beijing 125
Singapore 117
Boardman 112
Dearborn 92
Des Moines 92
New York 77
Princeton 71
Brooklyn 58
Milan 49
San Diego 47
Inglewood 44
Nanchang 42
Hebei 41
Jiaxing 34
Marseille 34
Shenyang 34
Brussels 33
Dublin 27
Munich 27
Santa Clara 27
Guangzhou 25
Los Angeles 25
Kansas City 22
Redwood City 21
Paris 20
Tianjin 20
Dong Ket 14
Leawood 14
Shanghai 14
Washington 14
Ningbo 13
Wuxi 13
Augusta 12
Bitonto 12
Boydton 12
Changsha 12
London 12
Jinan 11
Norwalk 11
Wuhan 11
Zhengzhou 11
Helsinki 10
Pune 10
Ardabil 9
San Mateo 9
Gravina In Puglia 8
Hefei 8
Tehran 8
Auburn Hills 7
Brno 7
Kunming 7
Santa Marinella 7
Hangzhou 6
Prescot 6
Taizhou 6
Brindisi 5
Cerro Maggiore 5
Hounslow 5
Moscow 5
Nagold 5
Sheffield 5
Yiwu 5
Amsterdam 4
Cosenza 4
Frankfurt am Main 4
Guwahati 4
Jinhua 4
Kilburn 4
Monmouth Junction 4
Rome 4
Salice Salentino 4
Taranto 4
Toronto 4
Triggiano 4
Weihai 4
Xian 4
Almere Stad 3
Azrou 3
Edinburgh 3
Geneva 3
Kolkata 3
Molfetta 3
New Bedfont 3
New Delhi 3
Nürnberg 3
Totale 7.639
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Nome #
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 149
Multitarget Drug Design for Neurodegenerative Diseases 147
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 142
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 137
A rational approach to elucidate human monoamine oxidase molecular selectivity 134
Applicability Domain for QSAR models: where theory meets reality 133
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 131
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 129
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 127
Mind the Gap ! A Journey towards Computational Toxicology 125
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 121
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 120
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 118
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 118
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 115
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 114
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 112
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 112
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 111
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 111
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 108
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 104
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 102
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 100
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 99
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 98
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 98
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 96
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 96
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 94
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 93
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 92
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 91
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 90
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 88
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 88
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 87
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 87
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 85
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 85
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 84
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 84
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 83
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 83
null 81
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 81
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 76
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 76
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 75
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 74
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 73
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 73
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 71
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 70
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 70
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 70
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 69
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 69
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 69
Estimation of the Binding Free Energy by Linear Interaction Energy Models 69
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 68
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 68
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 67
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 66
A multitarget approach in cancer research 66
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 66
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 66
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 66
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 65
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 64
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 64
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 64
null 63
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 62
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 62
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 61
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 61
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 61
Anthracenedione and azaanthracenedione derivatives as agents able to inhibit aggregation of beta-amyloid peptides 60
Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7-Substituted Coumarins 60
A Multi-Objective Optimization Algorithm for Molecular Design 60
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 60
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 60
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 60
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 60
Synthesis and Inhibitory Activity Towards β-Amyloid Fibril Formation of Indane and Indole Derivatives 58
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 58
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 57
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 56
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 56
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 55
First selective dual inhibitors of tau phosphorylation and beta-amyloid aggregation, two major pathogenic mechanisms in Alzheimer’s disease 55
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 54
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 54
Recombinant human MAOB as reliable and efficient enzyme source for inhibitor screening 53
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 53
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 51
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 50
Hybrid inhibitors of Monoamine Oxidase B and Cholinesterases from a “designing in” chemical decoration of coumarin-based hit compounds 49
Discovery of a Novel Class of Potent Coumarin MAO-B inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one methanesulfonate (NW-1772) as a Highly Potent, Selective, Reversible and Orally Active MAO-B inhibitor 49
Totale 8.275
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Categoria #
all - tutte 42.833
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.833
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.818 0 0 50 205 214 195 259 192 264 167 206 66
2020/20211.541 184 172 72 66 165 81 151 89 127 208 155 71
2021/20221.191 53 194 35 26 48 50 61 48 68 142 177 289
2022/20232.153 304 239 148 174 305 226 19 241 341 54 62 40
2023/2024889 58 124 44 131 60 162 44 25 35 33 19 154
2024/2025421 134 90 197 0 0 0 0 0 0 0 0 0
Totale 10.242