IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 9.783
AS - Asia 4.636
EU - Europa 3.558
SA - Sud America 1.123
AF - Africa 192
Continente sconosciuto - Info sul continente non disponibili 6
OC - Oceania 6
AN - Antartide 2
Totale 19.306
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Nazione #
US - Stati Uniti d'America 9.600
SG - Singapore 1.796
CN - Cina 1.186
BR - Brasile 909
IT - Italia 609
SE - Svezia 596
DE - Germania 594
HK - Hong Kong 549
RU - Federazione Russa 536
VN - Vietnam 358
FR - Francia 286
GB - Regno Unito 253
FI - Finlandia 217
UA - Ucraina 189
IN - India 177
CA - Canada 82
ID - Indonesia 81
BD - Bangladesh 80
AR - Argentina 77
MX - Messico 62
TR - Turchia 53
JP - Giappone 47
IQ - Iraq 45
PL - Polonia 45
NL - Olanda 44
ZA - Sudafrica 42
BE - Belgio 39
CI - Costa d'Avorio 39
MA - Marocco 35
PH - Filippine 35
EC - Ecuador 34
IE - Irlanda 32
IR - Iran 28
PK - Pakistan 28
AT - Austria 27
CO - Colombia 27
ES - Italia 27
SA - Arabia Saudita 23
VE - Venezuela 23
EG - Egitto 17
TN - Tunisia 17
UZ - Uzbekistan 16
AE - Emirati Arabi Uniti 15
CL - Cile 15
CZ - Repubblica Ceca 15
LT - Lituania 15
MY - Malesia 15
PY - Paraguay 15
CR - Costa Rica 12
KE - Kenya 12
PE - Perù 12
NP - Nepal 10
OM - Oman 10
CH - Svizzera 9
DZ - Algeria 9
KR - Corea 9
AZ - Azerbaigian 8
JO - Giordania 8
KG - Kirghizistan 8
ET - Etiopia 7
IL - Israele 7
JM - Giamaica 7
TH - Thailandia 7
BO - Bolivia 6
SY - Repubblica araba siriana 6
TW - Taiwan 6
KZ - Kazakistan 5
LB - Libano 5
RO - Romania 5
AU - Australia 4
BY - Bielorussia 4
EU - Europa 4
NG - Nigeria 4
AL - Albania 3
AO - Angola 3
DO - Repubblica Dominicana 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
TT - Trinidad e Tobago 3
AM - Armenia 2
BB - Barbados 2
BH - Bahrain 2
GE - Georgia 2
GT - Guatemala 2
KW - Kuwait 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SO - Somalia 2
SR - Suriname 2
UY - Uruguay 2
XK - ???statistics.table.value.countryCode.XK??? 2
AQ - Antartide 1
BG - Bulgaria 1
BS - Bahamas 1
CU - Cuba 1
CV - Capo Verde 1
CY - Cipro 1
DK - Danimarca 1
GD - Grenada 1
Totale 19.286
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Città #
Ashburn 992
Singapore 964
Fairfield 921
Chandler 761
San Jose 580
Woodbridge 544
Hong Kong 534
Nyköping 460
Jacksonville 412
Houston 401
Seattle 371
Beijing 367
Ann Arbor 347
Cambridge 329
Dallas 324
Wilmington 319
Bari 180
Lauterbourg 161
Roxbury 149
Lawrence 145
Nanjing 132
Los Angeles 126
New York 124
Ho Chi Minh City 121
Council Bluffs 116
Boardman 110
Helsinki 108
Dearborn 92
Des Moines 92
São Paulo 82
Brooklyn 81
Munich 78
Princeton 71
Hanoi 69
Falkenstein 63
Santa Clara 63
Milan 61
Jakarta 59
North Bergen 52
Buffalo 49
San Diego 48
Moscow 45
Inglewood 44
Nanchang 43
Hebei 41
Frankfurt am Main 40
Abidjan 39
Brussels 39
Chicago 39
Tokyo 39
Atlanta 38
London 36
Marseille 36
Shenyang 36
Jiaxing 35
Dublin 31
Guangzhou 29
Orem 29
Paris 29
Warsaw 29
Johannesburg 28
Nuremberg 28
Rio de Janeiro 28
Belo Horizonte 27
Chennai 27
Montreal 27
Kansas City 23
San Francisco 23
Denver 22
Baghdad 21
Poplar 21
Redwood City 21
Shanghai 21
Tianjin 21
New Delhi 19
Toronto 19
Amsterdam 18
Mexico City 18
Haiphong 17
Rome 17
Phoenix 16
Porto Alegre 16
Stockholm 16
Boston 15
Brasília 15
Augusta 14
Bitonto 14
Dong Ket 14
Leawood 14
Quito 14
Tashkent 14
Washington 14
Wuhan 14
Changsha 13
Mumbai 13
Ningbo 13
Boydton 12
Campinas 12
Columbus 12
Da Nang 12
Totale 12.478
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Nome #
Applicability Domain for QSAR models: where theory meets reality 240
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 220
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 212
A rational approach to elucidate human monoamine oxidase molecular selectivity 202
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 202
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 201
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 198
Mind the Gap ! A Journey towards Computational Toxicology 190
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 188
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 187
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 185
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 183
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 183
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 182
Multitarget Drug Design for Neurodegenerative Diseases 181
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 180
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 180
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 180
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 178
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 177
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 169
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 168
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 165
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 163
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 162
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 161
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 160
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 160
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 157
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 157
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 154
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 153
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 148
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 146
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 143
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 139
A multitarget approach in cancer research 138
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 138
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 137
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 137
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 137
A Multi-Objective Optimization Algorithm for Molecular Design 136
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 135
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 134
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 133
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 132
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 131
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 131
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 131
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 130
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 128
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 127
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 126
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 125
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 123
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 121
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 120
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 119
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 119
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 117
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 116
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 116
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 115
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 113
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 112
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 111
Estimation of the Binding Free Energy by Linear Interaction Energy Models 111
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 110
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 109
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 108
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 108
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 108
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 107
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 107
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 106
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 105
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 104
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 104
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 104
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 101
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 101
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 101
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 101
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 100
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 100
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 99
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 97
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 96
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 96
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 96
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 96
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 96
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 95
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 95
Anthracenedione and azaanthracenedione derivatives as agents able to inhibit aggregation of beta-amyloid peptides 94
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 94
Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases 94
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 93
Totale 13.648
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Categoria #
all - tutte 76.928
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.928
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021434 0 0 0 0 0 0 0 0 0 208 155 71
2021/20221.191 53 194 35 26 48 50 61 48 68 142 177 289
2022/20232.136 302 237 146 173 301 226 19 240 338 52 62 40
2023/2024875 58 122 44 129 59 161 39 25 35 33 18 152
2024/20253.353 131 90 237 144 129 256 378 295 171 142 486 894
2025/20266.754 979 394 652 839 879 436 900 281 801 593 0 0
Totale 19.897