IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 8.557
AS - Asia 3.747
EU - Europa 3.071
SA - Sud America 900
AF - Africa 121
Continente sconosciuto - Info sul continente non disponibili 5
OC - Oceania 4
AN - Antartide 2
Totale 16.407
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Nazione #
US - Stati Uniti d'America 8.424
SG - Singapore 1.536
CN - Cina 1.056
BR - Brasile 788
SE - Svezia 595
DE - Germania 547
RU - Federazione Russa 526
HK - Hong Kong 511
IT - Italia 487
VN - Vietnam 250
GB - Regno Unito 231
UA - Ucraina 182
FI - Finlandia 154
FR - Francia 110
IN - India 107
ID - Indonesia 65
CA - Canada 63
AR - Argentina 46
MX - Messico 46
PL - Polonia 40
CI - Costa d'Avorio 39
BD - Bangladesh 38
BE - Belgio 37
NL - Olanda 35
IE - Irlanda 30
IR - Iran 28
AT - Austria 27
TR - Turchia 26
ZA - Sudafrica 26
IQ - Iraq 24
JP - Giappone 21
EC - Ecuador 20
ES - Italia 20
CZ - Repubblica Ceca 14
LT - Lituania 14
MA - Marocco 14
CO - Colombia 12
AE - Emirati Arabi Uniti 10
EG - Egitto 10
PE - Perù 10
VE - Venezuela 10
KR - Corea 8
TN - Tunisia 8
UZ - Uzbekistan 8
PH - Filippine 7
PK - Pakistan 7
PY - Paraguay 7
SA - Arabia Saudita 7
JM - Giamaica 6
KE - Kenya 6
CH - Svizzera 5
CL - Cile 5
CR - Costa Rica 5
DZ - Algeria 5
EU - Europa 4
JO - Giordania 4
OM - Oman 4
AO - Angola 3
BY - Bielorussia 3
ET - Etiopia 3
IL - Israele 3
KG - Kirghizistan 3
LB - Libano 3
MY - Malesia 3
NG - Nigeria 3
NP - Nepal 3
RO - Romania 3
AU - Australia 2
AZ - Azerbaigian 2
BB - Barbados 2
DO - Repubblica Dominicana 2
GT - Guatemala 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
TH - Thailandia 2
TW - Taiwan 2
AL - Albania 1
AM - Armenia 1
AQ - Antartide 1
BG - Bulgaria 1
BH - Bahrain 1
BS - Bahamas 1
CV - Capo Verde 1
CY - Cipro 1
DK - Danimarca 1
GD - Grenada 1
GE - Georgia 1
GI - Gibilterra 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HN - Honduras 1
IS - Islanda 1
KW - Kuwait 1
LA - Repubblica Popolare Democratica del Laos 1
MK - Macedonia 1
MW - Malawi 1
NI - Nicaragua 1
NO - Norvegia 1
PA - Panama 1
PR - Porto Rico 1
Totale 16.398
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Città #
Fairfield 921
Ashburn 872
Chandler 761
Singapore 761
Woodbridge 544
Hong Kong 505
Nyköping 460
Jacksonville 412
Houston 400
Seattle 368
Beijing 350
Ann Arbor 347
Cambridge 329
Dallas 319
Wilmington 319
Bari 178
Roxbury 149
Lawrence 145
Nanjing 132
New York 114
Los Angeles 111
Boardman 110
Dearborn 92
Des Moines 92
Ho Chi Minh City 91
Brooklyn 78
Munich 78
Princeton 71
São Paulo 66
Jakarta 57
Milan 57
North Bergen 52
Santa Clara 52
Buffalo 48
San Diego 47
Helsinki 45
Hanoi 44
Inglewood 44
Moscow 44
Nanchang 42
Hebei 41
Abidjan 39
Brussels 37
Falkenstein 37
Shenyang 36
Jiaxing 34
London 34
Marseille 34
Chicago 33
Council Bluffs 33
Dublin 29
Guangzhou 28
Nuremberg 26
Atlanta 25
Warsaw 25
Belo Horizonte 24
Frankfurt am Main 24
Rio de Janeiro 24
Kansas City 23
Montreal 23
Chennai 22
Paris 21
Redwood City 21
Tianjin 21
Johannesburg 20
San Francisco 20
Denver 18
Mexico City 17
Shanghai 17
Tokyo 17
Poplar 16
Stockholm 16
Brasília 15
Toronto 15
Augusta 14
Bitonto 14
Dong Ket 14
Leawood 14
Washington 14
Changsha 13
Ningbo 13
Porto Alegre 13
Amsterdam 12
Boston 12
Boydton 12
Campinas 12
Jinan 12
New Delhi 12
Phoenix 12
Rome 12
Wuhan 12
Wuxi 12
Columbus 11
Norwalk 11
The Dalles 11
Vienna 11
Zhengzhou 11
Ankara 10
Pune 10
Tehran 10
Totale 10.886
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Nome #
Applicability Domain for QSAR models: where theory meets reality 216
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 202
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 195
A rational approach to elucidate human monoamine oxidase molecular selectivity 185
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 183
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 178
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 177
Mind the Gap ! A Journey towards Computational Toxicology 173
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 170
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 169
Multitarget Drug Design for Neurodegenerative Diseases 169
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 167
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 166
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 164
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 163
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 163
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 162
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 160
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 154
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 152
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 146
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 146
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 145
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 145
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 144
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 143
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 142
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 141
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 141
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 136
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 135
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 134
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 133
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 129
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 128
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 126
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 124
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 124
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 122
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 122
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 121
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 121
A multitarget approach in cancer research 119
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 119
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 119
A Multi-Objective Optimization Algorithm for Molecular Design 118
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 118
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 118
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 116
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 115
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 115
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 111
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 110
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 108
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 108
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 108
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 107
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 107
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 106
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 106
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 105
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 105
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 105
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 103
Estimation of the Binding Free Energy by Linear Interaction Energy Models 103
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 102
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 101
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 101
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 100
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 100
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 95
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 95
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 95
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 95
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 95
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 94
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 94
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 93
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 93
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 92
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 91
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 91
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 89
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 89
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 87
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 86
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 85
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 84
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 83
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 83
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 82
Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7-Substituted Coumarins 82
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 82
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 82
Anthracenedione and azaanthracenedione derivatives as agents able to inhibit aggregation of beta-amyloid peptides 81
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 81
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 80
Synthesis and Biological Evaluation of Dantrolene-Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases 80
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 79
Synthesis and Inhibitory Activity Towards β-Amyloid Fibril Formation of Indane and Indole Derivatives 79
Totale 12.086
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Categoria #
all - tutte 71.300
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 71.300
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021882 0 0 0 0 0 81 151 89 127 208 155 71
2021/20221.191 53 194 35 26 48 50 61 48 68 142 177 289
2022/20232.136 302 237 146 173 301 226 19 240 338 52 62 40
2023/2024875 58 122 44 129 59 161 39 25 35 33 18 152
2024/20253.353 131 90 237 144 129 256 378 295 171 142 486 894
2025/20263.854 979 394 652 839 879 111 0 0 0 0 0 0
Totale 16.997