IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 6.855
EU - Europa 2.145
AS - Asia 1.129
AF - Africa 12
SA - Sud America 8
Continente sconosciuto - Info sul continente non disponibili 4
AN - Antartide 1
Totale 10.154
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Nazione #
US - Stati Uniti d'America 6.842
CN - Cina 712
SE - Svezia 578
DE - Germania 411
IT - Italia 411
SG - Singapore 310
UA - Ucraina 169
GB - Regno Unito 146
FI - Finlandia 133
RU - Federazione Russa 118
FR - Francia 69
IN - India 42
BE - Belgio 34
IE - Irlanda 27
IR - Iran 26
NL - Olanda 18
VN - Vietnam 14
CA - Canada 11
CZ - Repubblica Ceca 9
TR - Turchia 6
CH - Svizzera 5
LT - Lituania 5
EG - Egitto 4
EU - Europa 4
JP - Giappone 4
MA - Marocco 4
HK - Hong Kong 3
KR - Corea 3
PL - Polonia 3
RO - Romania 3
BR - Brasile 2
DZ - Algeria 2
ES - Italia 2
MX - Messico 2
NG - Nigeria 2
PE - Perù 2
TH - Thailandia 2
AM - Armenia 1
AR - Argentina 1
AT - Austria 1
CL - Cile 1
CO - Colombia 1
DK - Danimarca 1
EC - Ecuador 1
GS - Georgia del Sud e Isole Sandwich Australi 1
ID - Indonesia 1
IL - Israele 1
IQ - Iraq 1
IS - Islanda 1
NO - Norvegia 1
NP - Nepal 1
PH - Filippine 1
TW - Taiwan 1
Totale 10.154
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Città #
Fairfield 921
Chandler 761
Woodbridge 544
Ashburn 489
Nyköping 460
Jacksonville 411
Houston 390
Seattle 359
Ann Arbor 347
Cambridge 329
Wilmington 315
Singapore 258
Bari 162
Roxbury 149
Lawrence 145
Nanjing 132
Beijing 126
Boardman 110
Dearborn 92
Des Moines 92
New York 77
Princeton 71
Brooklyn 58
Milan 53
San Diego 47
Inglewood 44
Nanchang 42
Hebei 41
Brussels 34
Jiaxing 34
Marseille 34
Shenyang 34
Helsinki 31
Munich 30
Santa Clara 30
Dublin 27
Guangzhou 26
Los Angeles 26
Kansas City 22
Redwood City 21
Paris 20
Tianjin 20
London 19
Shanghai 16
Bitonto 14
Dong Ket 14
Leawood 14
Washington 14
Ningbo 13
Augusta 12
Boydton 12
Changsha 12
Jinan 12
Wuxi 12
Norwalk 11
Wuhan 11
Zhengzhou 11
Pune 10
Ardabil 9
San Mateo 9
Gravina In Puglia 8
Hefei 8
Kunming 8
Tehran 8
Auburn Hills 7
Brno 7
Santa Marinella 7
Hangzhou 6
Taizhou 6
Brindisi 5
Cerro Maggiore 5
Frankfurt am Main 5
Hounslow 5
Kolkata 5
Moscow 5
Nagold 5
Prescot 5
Sheffield 5
Toronto 5
Yiwu 5
Amsterdam 4
Cosenza 4
Guwahati 4
Jinhua 4
Kilburn 4
Monmouth Junction 4
Rome 4
Romola 4
Salice Salentino 4
Taranto 4
Triggiano 4
Weihai 4
Xian 4
Almere Stad 3
Azrou 3
Edinburgh 3
Fuzhou 3
Geneva 3
Molfetta 3
New Bedfont 3
Totale 7.832
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Nome #
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 151
Applicability Domain for QSAR models: where theory meets reality 148
Multitarget Drug Design for Neurodegenerative Diseases 147
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 143
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 141
A rational approach to elucidate human monoamine oxidase molecular selectivity 138
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 133
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 132
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 129
Mind the Gap ! A Journey towards Computational Toxicology 127
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 124
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 124
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 124
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 121
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 119
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 117
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 117
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 113
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 113
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 112
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 112
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 109
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 104
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 102
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 100
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 99
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 99
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 99
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 98
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 95
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 94
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 94
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 92
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 92
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 91
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 89
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 89
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 88
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 88
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 86
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 86
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 85
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 84
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 84
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 83
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 81
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 78
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 77
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 77
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 76
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 75
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 74
A multitarget approach in cancer research 73
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 73
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 73
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 73
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 73
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 72
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 72
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 71
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 71
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 70
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 70
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 69
Estimation of the Binding Free Energy by Linear Interaction Energy Models 69
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 69
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 69
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 68
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 67
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 67
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 67
A Multi-Objective Optimization Algorithm for Molecular Design 64
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 64
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 64
Discovery of a potent and selective hetero-bivalent AChE inhibitor via bioisosteric replacement 64
null 63
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity 63
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 63
Lipophilicity Plays a Major Role in Modulating the Inhibition of Monoamine Oxidase B by 7-Substituted Coumarins 62
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 62
Structure-Based Design, Solid Phase Synthesis and SAFIR of New Dual Binding Site Acetylcholinesterase (AChE) Inhibitors. 62
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors 62
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 62
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 61
Anthracenedione and azaanthracenedione derivatives as agents able to inhibit aggregation of beta-amyloid peptides 60
Synthesis and Inhibitory Activity Towards β-Amyloid Fibril Formation of Indane and Indole Derivatives 60
New Strategies in the Chemotherapy of Leukemia: Eradicating Cancer Stem Cells in Chronic Myeloid Leukemia 60
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 60
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease 60
Coumarin as a versatile scaffold to selectively target biologically relevant cytochrome P450 enzymes: aromatase, steroid 11β-hydroxylase and aldosterone synthase 59
Design of multiple-target anticancer agents: a daunting challenge for the medicinal chemist 57
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 57
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 57
Identification of Natural Scaffolds as New Multi-Functional Agents for the Treatment of Alzheimer’s Disease 56
Heterodimeric dual binding site cholinesterase inhibitors: surfing on the sub-nanomolar affinity 55
First selective dual inhibitors of tau phosphorylation and beta-amyloid aggregation, two major pathogenic mechanisms in Alzheimer’s disease 55
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 55
Recombinant human MAOB as reliable and efficient enzyme source for inhibitor screening 54
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 53
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 53
Totale 8.516
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Categoria #
all - tutte 47.243
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 47.243
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.349 0 0 0 0 0 195 259 192 264 167 206 66
2020/20211.541 184 172 72 66 165 81 151 89 127 208 155 71
2021/20221.191 53 194 35 26 48 50 61 48 68 142 177 289
2022/20232.136 302 237 146 173 301 226 19 240 338 52 62 40
2023/2024875 58 122 44 129 59 161 39 25 35 33 18 152
2024/2025898 131 90 237 144 129 167 0 0 0 0 0 0
Totale 10.688