IRIS
CATTO, Marco
 Distribuzione geografica
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Continente #
NA - Nord America 10.904
AS - Asia 4.744
EU - Europa 4.380
SA - Sud America 1.154
Continente sconosciuto - Info sul continente non disponibili 635
AF - Africa 194
OC - Oceania 6
AN - Antartide 2
Totale 22.019
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Nazione #
US - Stati Uniti d'America 10.673
SG - Singapore 1.817
IT - Italia 1.408
CN - Cina 1.215
BR - Brasile 922
SE - Svezia 598
DE - Germania 594
HK - Hong Kong 559
RU - Federazione Russa 537
VN - Vietnam 360
FR - Francia 289
GB - Regno Unito 256
FI - Finlandia 217
UA - Ucraina 191
IN - India 182
CA - Canada 109
BD - Bangladesh 102
AR - Argentina 81
ID - Indonesia 81
MX - Messico 65
TR - Turchia 53
JP - Giappone 47
NL - Olanda 46
IQ - Iraq 45
PL - Polonia 45
ZA - Sudafrica 42
BE - Belgio 39
CI - Costa d'Avorio 39
PH - Filippine 38
EC - Ecuador 37
CO - Colombia 35
MA - Marocco 35
IE - Irlanda 32
IR - Iran 31
PK - Pakistan 31
AT - Austria 27
ES - Italia 27
SA - Arabia Saudita 25
VE - Venezuela 25
EG - Egitto 18
CR - Costa Rica 17
CZ - Repubblica Ceca 16
MY - Malesia 16
TN - Tunisia 16
UZ - Uzbekistan 16
AE - Emirati Arabi Uniti 15
CL - Cile 15
LT - Lituania 15
PY - Paraguay 15
KE - Kenya 13
PE - Perù 12
CH - Svizzera 11
JM - Giamaica 11
NP - Nepal 10
OM - Oman 10
TH - Thailandia 10
AZ - Azerbaigian 9
DZ - Algeria 9
KR - Corea 9
JO - Giordania 8
KG - Kirghizistan 8
ET - Etiopia 7
IL - Israele 7
BO - Bolivia 6
RO - Romania 6
SY - Repubblica araba siriana 6
TW - Taiwan 6
KZ - Kazakistan 5
LB - Libano 5
TT - Trinidad e Tobago 5
AU - Australia 4
BY - Bielorussia 4
EU - Europa 4
NG - Nigeria 4
SK - Slovacchia (Repubblica Slovacca) 4
AL - Albania 3
AM - Armenia 3
AO - Angola 3
DO - Repubblica Dominicana 3
GT - Guatemala 3
HN - Honduras 3
NI - Nicaragua 3
PA - Panama 3
RS - Serbia 3
UY - Uruguay 3
BB - Barbados 2
BH - Bahrain 2
DK - Danimarca 2
GE - Georgia 2
KW - Kuwait 2
NZ - Nuova Zelanda 2
PS - Palestinian Territory 2
SO - Somalia 2
SR - Suriname 2
XK - ???statistics.table.value.countryCode.XK??? 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
AQ - Antartide 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
Totale 21.362
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Città #
Ashburn 1.082
Singapore 976
Fairfield 921
San Jose 783
Chandler 762
Hong Kong 544
Woodbridge 544
Milan 505
Nyköping 460
Jacksonville 413
Houston 404
Beijing 379
Seattle 373
Ann Arbor 347
Dallas 339
Cambridge 330
Wilmington 320
Council Bluffs 304
Bari 183
Lauterbourg 161
Boardman 155
Roxbury 149
Lawrence 145
New York 142
Los Angeles 137
Nanjing 132
Ho Chi Minh City 122
Rome 122
Helsinki 108
Santa Clara 96
Dearborn 92
Des Moines 92
Brooklyn 84
São Paulo 82
Munich 78
Princeton 71
Hanoi 69
Columbus 63
Falkenstein 63
Buffalo 60
Jakarta 59
North Bergen 53
Figino 51
San Diego 50
Chicago 49
Moscow 45
Inglewood 44
Nanchang 43
Atlanta 41
Hebei 41
Frankfurt am Main 40
Abidjan 39
Brussels 39
Tokyo 39
Montreal 38
London 37
Marseille 36
Shenyang 36
Jiaxing 35
Dublin 31
Orem 30
Guangzhou 29
Paris 29
Turin 29
Warsaw 29
Belo Horizonte 28
Johannesburg 28
Nuremberg 28
Phoenix 28
Rio de Janeiro 28
Kansas City 27
Chennai 26
San Francisco 26
Denver 24
Mexico City 22
Baghdad 21
Poplar 21
Redwood City 21
Shanghai 21
Tianjin 21
Naples 20
New Delhi 20
Toronto 20
Amsterdam 18
The Dalles 18
Haiphong 17
Augusta 16
Boston 16
Porto Alegre 16
Stockholm 16
Bologna 15
Brasília 15
Quito 15
San José 15
Washington 15
Bitonto 14
Boydton 14
Dong Ket 14
Leawood 14
Tashkent 14
Totale 13.876
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Nome #
Applicability Domain for QSAR models: where theory meets reality 256
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 241
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 219
A rational approach to elucidate human monoamine oxidase molecular selectivity 217
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 217
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 214
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 211
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 204
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 200
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 199
Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease 199
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 197
Mind the Gap ! A Journey towards Computational Toxicology 196
Alloxan Derivatives as Inhibitors of Matrix Metalloproteinase-2: Theoretical Calculations and Experimental Results 195
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 195
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 194
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 193
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 193
Multitarget Drug Design for Neurodegenerative Diseases 188
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 181
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 180
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 180
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 180
(EN) GALLOYL BENZAMIDE-BASED COMPOUNDS AS JNK MODULATORS (FR) COMPOSES A BASE DE GALLOYL BENZAMIDE UTILISES EN TANT QUE MODULATEURS DE JNK 178
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 173
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 173
Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors 173
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 170
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 168
Novel chemotypes targeting tubulin at the Colchicine binding site and unbiasing P-glycoprotein 168
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 164
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 164
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 162
A multitarget approach in cancer research 153
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 150
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase 149
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 149
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 148
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 146
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 145
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 145
6-Substituted-(E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides as novel, potent and selective MAO inhibitors 144
A Multi-Objective Optimization Algorithm for Molecular Design 144
4-(ALKYL)AMINOMETHYL-SUBSTITUTED COUMARINS AS POTENT AND SELECTIVE ACHE AND MAO-B DUAL INHIBITORS WITH A THERAPEUTIC POTENTIAL IN NEURODEGENERATIVE DISORDERS 143
A molecular dynamics study of a sub-nanomolar dual binding site heterodimeric AChE inhibitor. 142
An improved method for the biological evaluation of polyphenol derivatives as potential inhibitors of aβ(1–40) aggregation 142
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? 140
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 140
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 140
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 139
Multitarget-directed tricyclic pyridazinones as g protein-coupled receptor ligands and cholinesterase inhibitors. 134
A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE) 133
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 130
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 130
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 130
4-(Alkylamino)methyl-substituted coumarins as potent and selective AChE and MAO-B dual inhibitors with a therapeutic potential in neurodegenerative disorders 130
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 129
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 128
Estimation of the Binding Free Energy by Linear Interaction Energy Models 128
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles and isoxazoles with biological potential 125
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 124
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 124
3,4-Dihydroquinazoline derivatives as T-type Ca2+ channel blockers inhibit the activities of cholinesterase enzymes 123
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 123
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 122
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 122
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 121
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 118
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 117
Human recombinant monoamine oxidase B as reliable and efficient enzyme source for inhibitor screening 117
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterases 117
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 116
Solid Phase and Microwave Assisted Synthesis of Focused Libraries of Imatinib Analogues 116
A multitarget approach in cancer research. Joint Meeting on Medicinal Chemistry 116
Design, Synthesis and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors 116
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 116
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 115
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 114
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 114
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 114
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 113
Screening of new ligands selective for telomeric and oncogenic G-quadruplex sequences 111
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors 111
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors 110
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 110
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 110
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 109
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 107
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 107
A twenty-year journey exploring coumarin-based derivatives as bioactive molecules 106
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 105
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 105
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships 105
Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer’s drug candidates 105
Novel Phenothiazine/Donepezil-Like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease 104
Inhibiting Aβ1-40 in vitro aggregation by glycine-based molecular tongs: rational design and mechanistic implications 104
Alloxan derivatives as inhibitors of matrix metalloproteinases-2: theoretical calculations and experimental results 104
Totale 14.770
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Categoria #
all - tutte 86.516
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 86.516
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022944 0 0 35 26 48 50 61 48 68 142 177 289
2022/20232.136 302 237 146 173 301 226 19 240 338 52 62 40
2023/2024875 58 122 44 129 59 161 39 25 35 33 18 152
2024/20253.353 131 90 237 144 129 256 378 295 171 142 486 894
2025/20268.001 979 394 652 838 865 432 899 279 795 663 325 880
2026/2027875 236 358 281 0 0 0 0 0 0 0 0 0
Totale 22.019