IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 13.862
EU - Europa 6.836
AS - Asia 5.677
SA - Sud America 1.340
Continente sconosciuto - Info sul continente non disponibili 579
AF - Africa 211
OC - Oceania 8
AN - Antartide 1
Totale 28.514
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 13.616
SG - Singapore 2.171
DE - Germania 2.130
IT - Italia 1.534
CN - Cina 1.404
BR - Brasile 1.055
RU - Federazione Russa 730
SE - Svezia 718
HK - Hong Kong 673
GB - Regno Unito 428
VN - Vietnam 388
FR - Francia 341
UA - Ucraina 309
FI - Finlandia 274
IN - India 209
BD - Bangladesh 164
CA - Canada 103
ID - Indonesia 101
AR - Argentina 90
TR - Turchia 78
MX - Messico 67
ES - Italia 61
JP - Giappone 59
IQ - Iraq 55
EC - Ecuador 52
ZA - Sudafrica 52
NL - Olanda 50
IE - Irlanda 49
IR - Iran 48
CO - Colombia 47
BE - Belgio 46
PL - Polonia 43
PK - Pakistan 41
SA - Arabia Saudita 40
PH - Filippine 34
MA - Marocco 33
VE - Venezuela 32
CI - Costa d'Avorio 30
AT - Austria 26
UZ - Uzbekistan 22
CL - Cile 20
DZ - Algeria 19
TN - Tunisia 19
CZ - Repubblica Ceca 18
JM - Giamaica 18
AZ - Azerbaigian 17
EG - Egitto 17
KR - Corea 17
CR - Costa Rica 16
KZ - Kazakistan 16
MY - Malesia 16
JO - Giordania 15
LT - Lituania 15
TH - Thailandia 15
KE - Kenya 14
NP - Nepal 13
AE - Emirati Arabi Uniti 12
PY - Paraguay 12
IL - Israele 10
PE - Perù 10
UY - Uruguay 9
BO - Bolivia 8
OM - Oman 8
PA - Panama 8
CH - Svizzera 7
HU - Ungheria 7
KG - Kirghizistan 7
TT - Trinidad e Tobago 7
TW - Taiwan 7
AU - Australia 6
BY - Bielorussia 6
ET - Etiopia 6
GE - Georgia 6
SN - Senegal 6
BH - Bahrain 5
DO - Repubblica Dominicana 5
HN - Honduras 5
LB - Libano 5
RO - Romania 5
RS - Serbia 5
NI - Nicaragua 4
PS - Palestinian Territory 4
PT - Portogallo 4
AL - Albania 3
BB - Barbados 3
BG - Bulgaria 3
DK - Danimarca 3
HR - Croazia 3
KW - Kuwait 3
MD - Moldavia 3
MN - Mongolia 3
SK - Slovacchia (Repubblica Slovacca) 3
SR - Suriname 3
SY - Repubblica araba siriana 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
BS - Bahamas 2
CG - Congo 2
EE - Estonia 2
Totale 27.897
Salva come PNG Salva come JPEG
Città #
Ashburn 1.157
Dallas 1.106
Fairfield 1.100
Singapore 1.083
Chandler 963
San Jose 885
Woodbridge 843
Jacksonville 665
Hong Kong 651
Milan 606
Nyköping 498
Houston 473
Seattle 417
Cambridge 402
Ann Arbor 394
Wilmington 381
Beijing 365
Council Bluffs 352
Roxbury 201
Lawrence 197
Nanjing 193
Lauterbourg 192
Boardman 189
New York 181
Bari 170
Los Angeles 165
Rome 161
Des Moines 138
Santa Clara 127
Ho Chi Minh City 114
Brooklyn 108
Princeton 106
Helsinki 105
Dearborn 104
São Paulo 79
Figino 73
Hanoi 73
Columbus 67
Buffalo 62
Chicago 62
Inglewood 62
Nanchang 60
Jakarta 59
Munich 59
Falkenstein 54
North Bergen 53
San Diego 53
Hebei 51
Jiaxing 50
Tokyo 50
Shenyang 48
Dublin 47
London 42
Brussels 41
Montreal 40
Dong Ket 39
Rio de Janeiro 39
San Francisco 38
Atlanta 37
Frankfurt am Main 35
Marseille 34
Tianjin 34
Turin 33
Phoenix 32
Abidjan 30
Guangzhou 30
Paris 30
Nuremberg 29
Denver 28
Leawood 28
Moscow 28
San Mateo 28
Johannesburg 27
Warsaw 27
Augusta 26
Orem 25
Changsha 24
Ardabil 23
Boston 23
Baghdad 22
Kansas City 22
Shanghai 21
Stockholm 21
Washington 21
Belo Horizonte 20
Florence 20
Haiphong 20
Jeddah 20
Tashkent 20
Mexico City 19
Naples 19
Chennai 18
Guayaquil 18
Jinan 18
The Dalles 18
Ankara 17
Brasília 17
Istanbul 17
Porto Alegre 17
Salvador 17
Totale 17.106
Salva come PNG Salva come JPEG
Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.120
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 246
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 222
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 219
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 211
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 204
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 200
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 199
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 198
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 197
Mind the Gap ! A Journey towards Computational Toxicology 196
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 195
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 194
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 193
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 186
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 185
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 183
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 183
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 182
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 179
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 179
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 178
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 174
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 172
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 170
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 169
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 168
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 167
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 167
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 165
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 164
Partitioning behaviour of piracetam-type cognition enhancers 163
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 162
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 162
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 157
Le applicazioni della chimica farmaceutica 155
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 154
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 152
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 151
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 150
Protein crystallography and fragment-based drug design 150
Advanced methodologies in medicinal chemistry research 146
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 146
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 146
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 145
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 145
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 143
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 142
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 141
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 140
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 140
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 139
Comparative Molecular Field Analysis (CoMFA) 138
Organofluorine-containing therapeutics for treatment of cardiovascular disease 138
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 137
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 136
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 136
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 135
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 135
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 134
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 133
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 132
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 132
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 132
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 131
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 130
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 130
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 129
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 129
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 128
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 128
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 128
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 127
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 127
Lipophilicity in Molecular Modeling of MAO Inhibitors. 126
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 126
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 126
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 125
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 125
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 124
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 123
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 122
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 121
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 121
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 120
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 120
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 118
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 117
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 116
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 116
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 116
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 116
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 116
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 116
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 114
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 114
HIGHLY WATER-SOLUBLE DERIVATIVES OF THE ANESTHETIC AGENT PROPOFOL: IN VITRO AND IN VIVO EVALUATION OF CYCLIC AMINO ACID ESTERS 114
Totale 16.032
Salva come PNG Salva come JPEG
Categoria #
all - tutte 105.518
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 105.518
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.266 0 0 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20253.777 109 61 315 165 109 299 366 324 217 164 561 1.087
2025/20269.577 1.114 581 1.230 940 870 505 942 310 874 788 334 1.089
2026/20271.056 275 445 336 0 0 0 0 0 0 0 0 0
Totale 28.514