IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 15.365
EU - Europa 6.993
AS - Asia 5.713
SA - Sud America 1.372
Continente sconosciuto - Info sul continente non disponibili 596
AF - Africa 221
OC - Oceania 9
AN - Antartide 1
Totale 30.270
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Nazione #
US - Stati Uniti d'America 14.916
SG - Singapore 2.176
DE - Germania 2.137
IT - Italia 1.611
CN - Cina 1.408
BR - Brasile 1.080
RU - Federazione Russa 744
SE - Svezia 718
HK - Hong Kong 674
GB - Regno Unito 448
VN - Vietnam 388
FR - Francia 345
UA - Ucraina 311
FI - Finlandia 274
IN - India 209
CA - Canada 187
BD - Bangladesh 164
ID - Indonesia 101
AR - Argentina 91
TR - Turchia 78
MX - Messico 70
ES - Italia 62
JP - Giappone 61
IQ - Iraq 56
EC - Ecuador 54
ZA - Sudafrica 53
NL - Olanda 52
IE - Irlanda 51
CO - Colombia 49
IR - Iran 48
PL - Polonia 48
BE - Belgio 46
PK - Pakistan 42
SA - Arabia Saudita 40
CR - Costa Rica 38
LT - Lituania 36
MA - Marocco 34
PH - Filippine 34
VE - Venezuela 34
CI - Costa d'Avorio 30
IL - Israele 30
AT - Austria 26
TT - Trinidad e Tobago 25
SV - El Salvador 23
UZ - Uzbekistan 22
CL - Cile 20
DZ - Algeria 20
JM - Giamaica 20
TN - Tunisia 19
CZ - Repubblica Ceca 18
AZ - Azerbaigian 17
EG - Egitto 17
KR - Corea 17
KZ - Kazakistan 17
MY - Malesia 16
NI - Nicaragua 16
TH - Thailandia 16
CW - ???statistics.table.value.countryCode.CW??? 15
JO - Giordania 15
GT - Guatemala 14
KE - Kenya 14
HN - Honduras 13
NP - Nepal 13
AE - Emirati Arabi Uniti 12
PY - Paraguay 12
PE - Perù 10
PR - Porto Rico 10
UY - Uruguay 9
BO - Bolivia 8
OM - Oman 8
PA - Panama 8
SC - Seychelles 8
CH - Svizzera 7
GP - Guadalupe 7
HU - Ungheria 7
KG - Kirghizistan 7
TW - Taiwan 7
AU - Australia 6
BY - Bielorussia 6
ET - Etiopia 6
GE - Georgia 6
SN - Senegal 6
BH - Bahrain 5
DO - Repubblica Dominicana 5
LB - Libano 5
RO - Romania 5
RS - Serbia 5
EE - Estonia 4
PS - Palestinian Territory 4
PT - Portogallo 4
AL - Albania 3
BB - Barbados 3
BG - Bulgaria 3
DK - Danimarca 3
HR - Croazia 3
KW - Kuwait 3
MD - Moldavia 3
MN - Mongolia 3
SK - Slovacchia (Repubblica Slovacca) 3
SR - Suriname 3
Totale 29.638
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Città #
Ashburn 1.517
Dallas 1.122
Fairfield 1.100
Singapore 1.083
San Jose 1.017
Chandler 963
Woodbridge 843
Jacksonville 666
Hong Kong 652
Milan 611
Nyköping 498
Houston 474
Seattle 419
Cambridge 402
Ann Arbor 394
Wilmington 382
Beijing 366
Council Bluffs 364
New York 201
Roxbury 201
Lawrence 197
Nanjing 193
Lauterbourg 192
Boardman 191
Bari 172
Los Angeles 172
Rome 167
Santa Clara 160
Des Moines 138
Ho Chi Minh City 114
Brooklyn 110
Princeton 106
Helsinki 105
Dearborn 104
São Paulo 100
Washington 80
Figino 73
Hanoi 73
Chicago 70
Columbus 67
North Bergen 64
Buffalo 63
Inglewood 62
Nanchang 60
Jakarta 59
Munich 59
Falkenstein 54
San Diego 54
Tokyo 52
Hebei 51
Jiaxing 50
Dublin 49
Shenyang 48
Montreal 46
Atlanta 45
London 44
Phoenix 42
San Francisco 42
Brussels 41
Turin 40
Dong Ket 39
Rio de Janeiro 39
Frankfurt am Main 35
Marseille 34
Tianjin 34
San José 31
Abidjan 30
Denver 30
Guangzhou 30
Paris 30
Nuremberg 29
Warsaw 29
Leawood 28
Moscow 28
San Mateo 28
Johannesburg 27
Naples 27
Augusta 26
Boston 26
Orem 26
Changsha 24
Toronto 24
Ardabil 23
Kansas City 23
Baghdad 22
Vilnius 22
Florence 21
Shanghai 21
Stockholm 21
Belo Horizonte 20
Haiphong 20
Jeddah 20
Tashkent 20
Jinan 19
Mexico City 19
Miami 19
San Salvador 19
Chennai 18
Guayaquil 18
Newark 18
Totale 17.901
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.141
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 262
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 228
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 227
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 225
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 220
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 214
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 212
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 211
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 208
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 206
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 205
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 204
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 202
Mind the Gap ! A Journey towards Computational Toxicology 201
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 201
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 193
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 192
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 192
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 190
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 188
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 183
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 181
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 181
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 180
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 179
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 179
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 176
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 176
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 174
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 173
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 171
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 170
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 170
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 168
Partitioning behaviour of piracetam-type cognition enhancers 165
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 159
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 158
Le applicazioni della chimica farmaceutica 157
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 155
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 155
Protein crystallography and fragment-based drug design 154
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 154
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 153
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 153
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 151
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 150
Advanced methodologies in medicinal chemistry research 150
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 150
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 149
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 148
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 148
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 148
Organofluorine-containing therapeutics for treatment of cardiovascular disease 147
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 146
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 145
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 143
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 142
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 141
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 140
Comparative Molecular Field Analysis (CoMFA) 140
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 140
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 140
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 139
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 139
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 139
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 137
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 137
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 136
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 135
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 135
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 135
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 133
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 133
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 133
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 133
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 132
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 132
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 131
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 130
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 130
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 130
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 129
Lipophilicity in Molecular Modeling of MAO Inhibitors. 129
L’IRSP nella determinazione di aril-nipecotati in siero 129
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 129
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 129
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 128
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 128
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 126
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 126
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 126
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 126
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 126
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 124
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 123
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 122
HIGHLY WATER-SOLUBLE DERIVATIVES OF THE ANESTHETIC AGENT PROPOFOL: IN VITRO AND IN VIVO EVALUATION OF CYCLIC AMINO ACID ESTERS 122
Wasserlossliche Medikamentenvorstufen von Propofol 121
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 121
Totale 16.777
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Categoria #
all - tutte 111.638
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 111.638
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.156 0 0 0 0 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20253.777 109 61 315 165 109 299 366 324 217 164 561 1.087
2025/20269.577 1.114 581 1.230 940 870 505 942 310 874 788 334 1.089
2026/20272.812 275 445 700 1.290 102 0 0 0 0 0 0 0
Totale 30.270