IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 13.154
EU - Europa 6.795
AS - Asia 5.619
SA - Sud America 1.321
AF - Africa 208
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 3
AN - Antartide 1
Totale 27.109
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Nazione #
US - Stati Uniti d'America 12.934
SG - Singapore 2.165
DE - Germania 2.130
IT - Italia 1.500
CN - Cina 1.392
BR - Brasile 1.049
RU - Federazione Russa 730
SE - Svezia 716
HK - Hong Kong 670
GB - Regno Unito 428
VN - Vietnam 382
FR - Francia 341
UA - Ucraina 307
FI - Finlandia 274
IN - India 209
BD - Bangladesh 148
ID - Indonesia 99
CA - Canada 96
AR - Argentina 87
TR - Turchia 77
MX - Messico 67
ES - Italia 60
JP - Giappone 59
IQ - Iraq 55
ZA - Sudafrica 52
EC - Ecuador 50
NL - Olanda 50
IE - Irlanda 49
IR - Iran 48
BE - Belgio 46
PL - Polonia 43
CO - Colombia 42
PK - Pakistan 38
SA - Arabia Saudita 38
MA - Marocco 33
PH - Filippine 31
CI - Costa d'Avorio 30
VE - Venezuela 29
AT - Austria 26
UZ - Uzbekistan 22
CL - Cile 20
DZ - Algeria 19
TN - Tunisia 19
CZ - Repubblica Ceca 18
AZ - Azerbaigian 17
EG - Egitto 17
KR - Corea 17
MY - Malesia 16
JO - Giordania 15
LT - Lituania 15
TH - Thailandia 15
KZ - Kazakistan 14
JM - Giamaica 13
KE - Kenya 13
NP - Nepal 13
AE - Emirati Arabi Uniti 12
CR - Costa Rica 12
PY - Paraguay 12
IL - Israele 10
PE - Perù 10
UY - Uruguay 9
BO - Bolivia 8
OM - Oman 8
CH - Svizzera 7
HU - Ungheria 7
TW - Taiwan 7
AU - Australia 6
BY - Bielorussia 6
ET - Etiopia 6
GE - Georgia 6
KG - Kirghizistan 6
PA - Panama 6
SN - Senegal 6
DO - Repubblica Dominicana 5
LB - Libano 5
RO - Romania 5
TT - Trinidad e Tobago 5
BH - Bahrain 4
HN - Honduras 4
PS - Palestinian Territory 4
PT - Portogallo 4
RS - Serbia 4
AL - Albania 3
BG - Bulgaria 3
DK - Danimarca 3
KW - Kuwait 3
MD - Moldavia 3
MN - Mongolia 3
NI - Nicaragua 3
SK - Slovacchia (Repubblica Slovacca) 3
SR - Suriname 3
SY - Repubblica araba siriana 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BS - Bahamas 2
EE - Estonia 2
EU - Europa 2
GR - Grecia 2
Totale 27.073
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Città #
Ashburn 1.127
Fairfield 1.099
Dallas 1.093
Singapore 1.078
Chandler 963
Woodbridge 843
San Jose 745
Jacksonville 665
Hong Kong 648
Milan 602
Nyköping 498
Houston 473
Seattle 417
Cambridge 402
Ann Arbor 394
Wilmington 378
Beijing 358
Roxbury 201
Lawrence 196
Nanjing 193
Lauterbourg 192
Boardman 187
New York 174
Bari 169
Rome 159
Los Angeles 150
Des Moines 138
Ho Chi Minh City 113
Council Bluffs 112
Santa Clara 112
Brooklyn 108
Princeton 106
Helsinki 105
Dearborn 104
São Paulo 79
Figino 73
Hanoi 73
Columbus 67
Inglewood 62
Nanchang 60
Jakarta 59
Munich 59
Buffalo 57
Falkenstein 54
North Bergen 53
San Diego 52
Hebei 51
Jiaxing 50
Tokyo 50
Shenyang 48
Dublin 47
Chicago 44
London 42
Brussels 41
Dong Ket 39
Montreal 38
Rio de Janeiro 38
San Francisco 37
Atlanta 36
Frankfurt am Main 35
Marseille 34
Tianjin 34
Turin 33
Abidjan 30
Guangzhou 30
Paris 30
Nuremberg 29
Denver 28
Leawood 28
Moscow 28
San Mateo 28
Johannesburg 27
Warsaw 27
Augusta 26
Orem 25
Changsha 24
Ardabil 23
Baghdad 22
Shanghai 21
Stockholm 21
Washington 21
Belo Horizonte 20
Boston 20
Florence 20
Haiphong 20
Kansas City 20
Tashkent 20
Mexico City 19
Naples 19
Chennai 18
Jeddah 18
Jinan 18
The Dalles 18
Ankara 17
Brasília 17
Istanbul 17
Porto Alegre 17
Salvador 17
Amsterdam 16
Guayaquil 16
Totale 16.562
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.114
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 229
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 216
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 216
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 208
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 201
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 199
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 196
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 195
Mind the Gap ! A Journey towards Computational Toxicology 194
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 193
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 190
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 189
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 189
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 185
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 183
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 183
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 181
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 179
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 179
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 177
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 176
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 173
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 171
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 169
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 166
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 165
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 163
Partitioning behaviour of piracetam-type cognition enhancers 162
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 162
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 161
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 161
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 160
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 158
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 154
Le applicazioni della chimica farmaceutica 152
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 152
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 151
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 150
Protein crystallography and fragment-based drug design 147
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 144
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 144
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 143
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 142
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 142
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 142
Advanced methodologies in medicinal chemistry research 140
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 140
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 139
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 139
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 138
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 137
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 136
Comparative Molecular Field Analysis (CoMFA) 136
Organofluorine-containing therapeutics for treatment of cardiovascular disease 136
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 135
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 134
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 133
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 133
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 132
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 129
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 129
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 128
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 128
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 127
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 127
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 127
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 127
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 127
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 126
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 126
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 125
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 125
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 125
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 124
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 124
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 124
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 123
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 123
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 122
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 121
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 120
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 120
Lipophilicity in Molecular Modeling of MAO Inhibitors. 119
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 117
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 115
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 115
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 114
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 114
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 114
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 114
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 113
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 113
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 113
TIRESIA: An eXplainable Artificial Intelligence Platform for Predicting Developmental Toxicity 112
Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors 112
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 112
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 111
Totale 15.681
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Categoria #
all - tutte 102.302
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 102.302
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20253.777 109 61 315 165 109 299 366 324 217 164 561 1.087
2025/20269.577 1.114 581 1.230 940 870 505 942 310 874 788 334 1.089
2026/2027227 227 0 0 0 0 0 0 0 0 0 0 0
Totale 27.685