IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 8.795
EU - Europa 4.889
AS - Asia 1.708
SA - Sud America 300
AF - Africa 42
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
AN - Antartide 1
Totale 15.741
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Nazione #
US - Stati Uniti d'America 8.776
DE - Germania 1.999
CN - Cina 892
RU - Federazione Russa 698
SE - Svezia 695
SG - Singapore 489
IT - Italia 396
GB - Regno Unito 316
UA - Ucraina 293
BR - Brasile 277
FI - Finlandia 208
FR - Francia 87
IN - India 55
ID - Indonesia 50
IR - Iran 47
VN - Vietnam 47
IE - Irlanda 43
BE - Belgio 41
HK - Hong Kong 27
NL - Olanda 26
AT - Austria 20
ES - Italia 20
TR - Turchia 20
CZ - Repubblica Ceca 13
MA - Marocco 11
DZ - Algeria 9
CA - Canada 8
IQ - Iraq 8
LT - Lituania 8
JP - Giappone 7
KR - Corea 7
PK - Pakistan 7
TH - Thailandia 7
BD - Bangladesh 6
CO - Colombia 6
AZ - Azerbaigian 5
CH - Svizzera 5
GE - Georgia 5
HU - Ungheria 5
MX - Messico 5
AR - Argentina 4
EG - Egitto 4
IL - Israele 4
KE - Kenya 4
TN - Tunisia 4
TW - Taiwan 4
EC - Ecuador 3
OM - Oman 3
PH - Filippine 3
VE - Venezuela 3
ZA - Sudafrica 3
AU - Australia 2
BA - Bosnia-Erzegovina 2
BG - Bulgaria 2
BO - Bolivia 2
CL - Cile 2
ET - Etiopia 2
EU - Europa 2
JO - Giordania 2
KW - Kuwait 2
KZ - Kazakistan 2
NZ - Nuova Zelanda 2
PE - Perù 2
PL - Polonia 2
PT - Portogallo 2
RO - Romania 2
UZ - Uzbekistan 2
AL - Albania 1
AM - Armenia 1
AN - Antille olandesi 1
AO - Angola 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CR - Costa Rica 1
DO - Repubblica Dominicana 1
GA - Gabon 1
GH - Ghana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HN - Honduras 1
HR - Croazia 1
IS - Islanda 1
JM - Giamaica 1
LB - Libano 1
MY - Malesia 1
NG - Nigeria 1
NI - Nicaragua 1
NO - Norvegia 1
NP - Nepal 1
RS - Serbia 1
SA - Arabia Saudita 1
UY - Uruguay 1
Totale 15.741
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Città #
Fairfield 1.098
Chandler 963
Woodbridge 843
Jacksonville 663
Ashburn 559
Nyköping 498
Houston 458
Seattle 406
Cambridge 402
Ann Arbor 394
Wilmington 372
Singapore 282
Roxbury 201
Lawrence 196
Nanjing 193
Bari 158
Boardman 145
Des Moines 136
Beijing 129
New York 106
Princeton 105
Dearborn 104
Brooklyn 74
Inglewood 62
Nanchang 60
Hebei 51
San Diego 51
Helsinki 50
Jiaxing 50
North Bergen 50
Santa Clara 48
Shenyang 48
Jakarta 47
Milan 43
Dublin 42
Dong Ket 39
Brussels 38
Marseille 33
Tianjin 33
Guangzhou 28
Leawood 28
San Mateo 28
Los Angeles 26
Moscow 26
Augusta 24
Ardabil 23
Changsha 22
Paris 21
Hong Kong 20
London 20
Nuremberg 19
Shanghai 19
Jinan 18
Washington 18
Munich 17
Kansas City 14
Redwood City 14
Zhengzhou 14
Frankfurt am Main 13
Council Bluffs 12
Kunming 12
Ningbo 12
Wuxi 12
Hefei 11
Monmouth Junction 11
Norwalk 11
Vienna 11
Belo Horizonte 10
San Francisco 10
São Paulo 10
West Jordan 10
Auburn Hills 9
Rio de Janeiro 9
Tehran 9
Brno 8
Hanoi 8
Pune 8
Wuhan 8
Salvador 7
Santa Marinella 7
Düsseldorf 6
Florence 6
Guwahati 6
Indiana 6
Rome 6
Romola 6
Taizhou 6
Terlizzi 6
Triggiano 6
Boydton 5
Brasília 5
Cerro Maggiore 5
Falkenstein 5
Falls Church 5
Gravina In Puglia 5
Istanbul 5
Jinhua 5
Kolkata 5
La Canada Flintridge 5
Naples 5
Totale 9.956
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 244
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 149
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 148
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 141
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 139
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 137
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 133
Mind the Gap ! A Journey towards Computational Toxicology 132
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 131
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 129
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 129
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 128
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 125
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 122
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 122
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 122
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 121
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 120
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 119
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 118
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 118
Partitioning behaviour of piracetam-type cognition enhancers 116
Protein crystallography and fragment-based drug design 116
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 115
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 110
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 110
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 109
Comparative Molecular Field Analysis (CoMFA) 109
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 108
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 108
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 107
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 107
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 107
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 105
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 104
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 103
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 102
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 102
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 102
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 101
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 101
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 100
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 99
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 98
Le applicazioni della chimica farmaceutica 97
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 97
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 97
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 97
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 96
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 96
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 96
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 96
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 95
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 95
Organofluorine-containing therapeutics for treatment of cardiovascular disease 95
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 94
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 94
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 94
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 93
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 92
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 90
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 90
Advanced methodologies in medicinal chemistry research 88
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 87
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 86
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 86
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 86
Determinazione del bilancio idrofilo-lipofilo di alcuni tensioattivi non-ionici mediante cromatografia planare in fase inversa 85
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 85
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 85
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 84
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 84
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 84
Binding Models of Reversible Inhibitors to Monoamine Oxidases 83
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 83
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 82
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 82
Lipophilicity in Molecular Modeling of MAO Inhibitors. 81
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 81
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 81
Novel factor Xa inhibitors: a patent review 81
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 81
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 80
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 80
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 79
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 79
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 79
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 79
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 77
Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents 77
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 76
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 76
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 76
Oxazolidinone Amide Antibiotics 75
Molecular Modeling of Thrombin and its Natural Mutants: Implications in Biochemistry, Pathophysiology and Drug Design 74
High affinity central benzodiazepine receptor ligands II: QSAR studies and CoMFA analysis pyrazolo(4,3-c)quinolin-3-ones 74
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 74
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 74
Electronic and Conformational Effects on the Lipophilicity of Isomers and Analogs of the Neurotoxin 1-methyl-4-phenylpyridinium MPPT) 73
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 73
Totale 10.020
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Categoria #
all - tutte 66.976
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 66.976
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020328 0 0 0 0 0 0 0 0 0 0 258 70
2020/20212.001 201 199 136 128 199 71 161 117 180 248 238 123
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20252.175 109 61 315 165 109 299 366 324 217 164 46 0
Totale 16.279