IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 8.658
EU - Europa 4.229
AS - Asia 1.237
AF - Africa 18
SA - Sud America 10
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
AN - Antartide 1
Totale 14.159
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Nazione #
US - Stati Uniti d'America 8.650
DE - Germania 1.952
CN - Cina 854
SE - Svezia 695
IT - Italia 347
GB - Regno Unito 306
UA - Ucraina 291
RU - Federazione Russa 229
FI - Finlandia 181
SG - Singapore 177
FR - Francia 78
IN - India 51
VN - Vietnam 47
IR - Iran 45
IE - Irlanda 42
BE - Belgio 36
ES - Italia 20
NL - Olanda 14
TR - Turchia 14
CZ - Repubblica Ceca 13
MA - Marocco 7
TH - Thailandia 7
DZ - Algeria 6
JP - Giappone 6
CH - Svizzera 5
GE - Georgia 5
HU - Ungheria 5
KR - Corea 5
IQ - Iraq 4
MX - Messico 4
BR - Brasile 3
CA - Canada 3
EG - Egitto 3
HK - Hong Kong 3
ID - Indonesia 3
PH - Filippine 3
AU - Australia 2
BG - Bulgaria 2
CO - Colombia 2
EC - Ecuador 2
EU - Europa 2
IL - Israele 2
KW - Kuwait 2
NZ - Nuova Zelanda 2
PL - Polonia 2
RO - Romania 2
TW - Taiwan 2
AM - Armenia 1
AN - Antille olandesi 1
AR - Argentina 1
AT - Austria 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BY - Bielorussia 1
CL - Cile 1
GH - Ghana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HR - Croazia 1
IS - Islanda 1
KZ - Kazakistan 1
LB - Libano 1
LT - Lituania 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
PE - Perù 1
PT - Portogallo 1
RS - Serbia 1
SA - Arabia Saudita 1
Totale 14.159
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Città #
Fairfield 1.098
Chandler 963
Woodbridge 843
Jacksonville 663
Ashburn 553
Nyköping 498
Houston 458
Seattle 406
Cambridge 402
Ann Arbor 394
Wilmington 372
Roxbury 201
Lawrence 196
Nanjing 188
Boardman 147
Singapore 143
Bari 141
Des Moines 136
Beijing 128
New York 106
Princeton 105
Dearborn 104
Brooklyn 74
Inglewood 62
Nanchang 60
Hebei 51
San Diego 51
Jiaxing 50
Shenyang 48
Santa Clara 46
Milan 43
Dublin 41
Dong Ket 39
Brussels 33
Marseille 33
Tianjin 33
Leawood 28
San Mateo 28
Guangzhou 25
Los Angeles 25
Augusta 24
Ardabil 23
Helsinki 23
Changsha 22
Paris 21
Washington 18
Jinan 17
London 16
Shanghai 16
Kansas City 14
Munich 14
Redwood City 14
Zhengzhou 14
Ningbo 12
Wuxi 12
Hefei 11
Kunming 11
Monmouth Junction 11
Norwalk 11
San Francisco 10
West Jordan 10
Auburn Hills 9
Wuhan 9
Brno 8
Hanoi 8
Pune 8
Santa Marinella 7
Tehran 7
Indiana 6
Taizhou 6
Terlizzi 6
Triggiano 6
Boydton 5
Cerro Maggiore 5
Falls Church 5
Florence 5
Gravina In Puglia 5
Istanbul 5
Jinhua 5
Kolkata 5
La Canada Flintridge 5
Moscow 5
Naples 5
New Delhi 5
Shenzhen 5
Amsterdam 4
Budapest 4
Chicago 4
Delhi 4
Guwahati 4
Hounslow 4
Kilburn 4
Napoli 4
Rome 4
Salice Salentino 4
St Albans 4
Weihai 4
Almere Stad 3
Azrou 3
Bologna 3
Totale 9.541
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 222
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 138
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 131
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 131
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 127
Mind the Gap ! A Journey towards Computational Toxicology 125
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 120
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 120
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 120
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 120
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 119
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 119
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 118
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 118
Partitioning behaviour of piracetam-type cognition enhancers 113
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 113
Protein crystallography and fragment-based drug design 112
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 112
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 112
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 111
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 111
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 110
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 106
Comparative Molecular Field Analysis (CoMFA) 106
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 105
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 104
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 104
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 104
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 103
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 102
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 102
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 101
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 101
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 101
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 100
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 98
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 98
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 97
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 97
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 96
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 95
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 94
Le applicazioni della chimica farmaceutica 93
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 93
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 92
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 92
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 91
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 91
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 91
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 91
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 90
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 90
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 90
Organofluorine-containing therapeutics for treatment of cardiovascular disease 90
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 90
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 89
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 87
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 83
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 83
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 83
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 82
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 81
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 80
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 80
Binding Models of Reversible Inhibitors to Monoamine Oxidases 79
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 79
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 78
Determinazione del bilancio idrofilo-lipofilo di alcuni tensioattivi non-ionici mediante cromatografia planare in fase inversa 77
Advanced methodologies in medicinal chemistry research 77
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 77
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 76
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 76
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 76
Lipophilicity in Molecular Modeling of MAO Inhibitors. 75
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 75
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 75
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 75
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 75
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 74
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 74
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 73
Novel factor Xa inhibitors: a patent review 73
Molecular Modeling of Thrombin and its Natural Mutants: Implications in Biochemistry, Pathophysiology and Drug Design 72
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 71
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 71
Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents 71
High affinity central benzodiazepine receptor ligands II: QSAR studies and CoMFA analysis pyrazolo(4,3-c)quinolin-3-ones 70
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 70
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 69
Neuronal nicotinic receptor agonists: multi-approach pharmacophore development and 3D-QSAR predictive models, 68
L'ISRP nella determinazione diretta di aril nipecotati in siero. 68
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 68
Synthesis and pharmacological evaluation of 1-[(1,2-Diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D2,Serotonin and GABAA receptors 68
High Affinity Central Benzodiazepine Receptor Ligands. Part 3: Insights into the Pharmacophore and Pattern Recognition Study of Intrinsic Activities of Pyrazolo[4,3-c]quinolin-3-ones 67
Derivatives of annulated tetrahydroazocines and tetrahydroazonines as cholinesterase inhibitors 67
Oxazolidinone Amide Antibiotics 67
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides 67
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of PD 66
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 66
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 66
Totale 9.264
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Categoria #
all - tutte 54.663
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.663
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.248 0 0 70 326 278 233 319 220 319 155 258 70
2020/20212.001 201 199 136 128 199 71 161 117 180 248 238 123
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.607 392 238 146 206 407 306 27 301 428 53 56 47
2023/20241.019 70 162 53 121 68 183 59 38 43 34 34 154
2024/2025460 110 61 289 0 0 0 0 0 0 0 0 0
Totale 14.574