IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 8.701
EU - Europa 4.486
AS - Asia 1.438
AF - Africa 20
SA - Sud America 14
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
AN - Antartide 1
Totale 14.666
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Nazione #
US - Stati Uniti d'America 8.691
DE - Germania 1.961
CN - Cina 885
SE - Svezia 695
RU - Federazione Russa 406
IT - Italia 372
SG - Singapore 332
GB - Regno Unito 314
UA - Ucraina 291
FI - Finlandia 202
FR - Francia 79
IN - India 53
VN - Vietnam 47
IR - Iran 45
IE - Irlanda 42
BE - Belgio 39
ES - Italia 20
NL - Olanda 19
TR - Turchia 16
CZ - Repubblica Ceca 13
HK - Hong Kong 10
MA - Marocco 8
KR - Corea 7
LT - Lituania 7
TH - Thailandia 7
BR - Brasile 6
DZ - Algeria 6
JP - Giappone 6
CA - Canada 5
CH - Svizzera 5
GE - Georgia 5
HU - Ungheria 5
IQ - Iraq 4
MX - Messico 4
TW - Taiwan 4
EG - Egitto 3
ID - Indonesia 3
PH - Filippine 3
AR - Argentina 2
AT - Austria 2
AU - Australia 2
BG - Bulgaria 2
CO - Colombia 2
EC - Ecuador 2
EU - Europa 2
IL - Israele 2
KW - Kuwait 2
NZ - Nuova Zelanda 2
PL - Polonia 2
PT - Portogallo 2
RO - Romania 2
AM - Armenia 1
AN - Antille olandesi 1
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BY - Bielorussia 1
CL - Cile 1
GH - Ghana 1
GS - Georgia del Sud e Isole Sandwich Australi 1
HR - Croazia 1
IS - Islanda 1
KZ - Kazakistan 1
LB - Libano 1
MY - Malesia 1
NG - Nigeria 1
NO - Norvegia 1
NP - Nepal 1
PE - Perù 1
RS - Serbia 1
SA - Arabia Saudita 1
TN - Tunisia 1
Totale 14.666
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Città #
Fairfield 1.098
Chandler 963
Woodbridge 843
Jacksonville 663
Ashburn 556
Nyköping 498
Houston 458
Seattle 406
Cambridge 402
Ann Arbor 394
Wilmington 372
Singapore 268
Roxbury 201
Lawrence 196
Nanjing 188
Bari 145
Boardman 145
Des Moines 136
Beijing 129
New York 106
Princeton 105
Dearborn 104
Brooklyn 74
Inglewood 62
Nanchang 60
Hebei 51
San Diego 51
Jiaxing 50
Santa Clara 48
Shenyang 48
Helsinki 44
Milan 43
Dublin 41
Dong Ket 39
Brussels 36
Marseille 33
Tianjin 33
Guangzhou 28
Leawood 28
San Mateo 28
Los Angeles 25
Augusta 24
Ardabil 23
Changsha 22
Paris 21
London 20
Shanghai 19
Jinan 18
Washington 18
Munich 17
Kansas City 14
Redwood City 14
Zhengzhou 14
Kunming 12
Ningbo 12
Wuxi 12
Hefei 11
Monmouth Junction 11
Norwalk 11
San Francisco 10
West Jordan 10
Auburn Hills 9
Brno 8
Hanoi 8
Pune 8
Wuhan 8
Santa Marinella 7
Tehran 7
Hong Kong 6
Indiana 6
Romola 6
Taizhou 6
Terlizzi 6
Triggiano 6
Boydton 5
Cerro Maggiore 5
Falls Church 5
Florence 5
Gravina In Puglia 5
Istanbul 5
Jinhua 5
Kolkata 5
La Canada Flintridge 5
Moscow 5
Naples 5
New Delhi 5
Rome 5
Shenzhen 5
Amsterdam 4
Budapest 4
Chicago 4
Delhi 4
Frankfurt am Main 4
Guwahati 4
Hounslow 4
Kilburn 4
Napoli 4
Salice Salentino 4
St Albans 4
Weihai 4
Totale 9.720
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 227
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 142
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 135
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 134
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 128
Mind the Gap ! A Journey towards Computational Toxicology 128
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 128
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 126
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 125
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 124
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 122
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 121
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 121
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 120
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 117
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 115
Partitioning behaviour of piracetam-type cognition enhancers 114
Protein crystallography and fragment-based drug design 114
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 113
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 113
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 113
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 112
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 109
Comparative Molecular Field Analysis (CoMFA) 108
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 107
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 106
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 106
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 106
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 105
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 104
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 104
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 104
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 102
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 102
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 102
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 100
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 99
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 98
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 97
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 97
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 96
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 95
Le applicazioni della chimica farmaceutica 94
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 94
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 94
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 94
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 94
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 93
Organofluorine-containing therapeutics for treatment of cardiovascular disease 93
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 92
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 92
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 92
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 92
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 92
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 92
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 91
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 91
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 86
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 85
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 85
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 84
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 84
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 83
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 83
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 82
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 81
Binding Models of Reversible Inhibitors to Monoamine Oxidases 81
Determinazione del bilancio idrofilo-lipofilo di alcuni tensioattivi non-ionici mediante cromatografia planare in fase inversa 81
Advanced methodologies in medicinal chemistry research 81
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 81
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 79
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 78
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 78
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 78
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 77
Lipophilicity in Molecular Modeling of MAO Inhibitors. 76
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 76
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 76
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 76
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 76
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 75
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 75
Ionization behaviour and tautomerism-dependent lipophilicity of pyridine-2(1H)-one cardiotonic agents 75
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 75
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 75
Novel factor Xa inhibitors: a patent review 74
Molecular Modeling of Thrombin and its Natural Mutants: Implications in Biochemistry, Pathophysiology and Drug Design 73
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 73
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 73
Inhibition of Monoamine Oxidases by Functionalized Coumarin Derivatives: Biological Activities, Quantitative Structure-Activity Relationships (QSARs) and 3D-QSAR 72
High affinity central benzodiazepine receptor ligands II: QSAR studies and CoMFA analysis pyrazolo(4,3-c)quinolin-3-ones 72
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 71
Neuronal nicotinic receptor agonists: multi-approach pharmacophore development and 3D-QSAR predictive models, 70
L'ISRP nella determinazione diretta di aril nipecotati in siero. 70
Thermodynamic Parameters, X-ray Structure, and QSAR Studies of Condensed Diazines as MAO Inhibitors 70
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 70
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 70
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 69
Synthesis and pharmacological evaluation of 1-[(1,2-Diphenyl-1H-4-imidazolyl)methyl]-4-phenylpiperazines with clozapine-like mixed activities at dopamine D2,Serotonin and GABAA receptors 69
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 69
Totale 9.516
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Categoria #
all - tutte 60.438
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 60.438
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.341 0 0 0 0 0 0 319 220 319 155 258 70
2020/20212.001 201 199 136 128 199 71 161 117 180 248 238 123
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20251.068 109 61 315 165 109 299 10 0 0 0 0 0
Totale 15.172