IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
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Continente #
NA - Nord America 12.525
EU - Europa 5.827
AS - Asia 5.526
SA - Sud America 1.309
AF - Africa 208
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 3
AN - Antartide 1
Totale 25.407
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Nazione #
US - Stati Uniti d'America 12.342
SG - Singapore 2.151
DE - Germania 2.130
CN - Cina 1.365
BR - Brasile 1.041
RU - Federazione Russa 730
SE - Svezia 716
HK - Hong Kong 657
IT - Italia 545
GB - Regno Unito 429
VN - Vietnam 383
FR - Francia 340
UA - Ucraina 307
FI - Finlandia 274
IN - India 203
BD - Bangladesh 122
ID - Indonesia 98
AR - Argentina 85
TR - Turchia 78
CA - Canada 77
MX - Messico 65
ES - Italia 59
JP - Giappone 59
IQ - Iraq 55
ZA - Sudafrica 52
EC - Ecuador 49
NL - Olanda 49
IE - Irlanda 48
IR - Iran 48
BE - Belgio 46
CO - Colombia 41
PL - Polonia 41
PK - Pakistan 38
SA - Arabia Saudita 37
MA - Marocco 33
PH - Filippine 31
CI - Costa d'Avorio 30
VE - Venezuela 29
AT - Austria 26
UZ - Uzbekistan 22
CL - Cile 20
TN - Tunisia 20
DZ - Algeria 19
CZ - Repubblica Ceca 17
EG - Egitto 17
KR - Corea 17
AZ - Azerbaigian 16
JO - Giordania 15
LT - Lituania 15
MY - Malesia 15
KE - Kenya 13
KZ - Kazakistan 13
NP - Nepal 13
AE - Emirati Arabi Uniti 12
PY - Paraguay 12
TH - Thailandia 12
IL - Israele 10
PE - Perù 10
CR - Costa Rica 9
JM - Giamaica 9
UY - Uruguay 9
BO - Bolivia 8
OM - Oman 8
HU - Ungheria 7
TW - Taiwan 7
AU - Australia 6
BY - Bielorussia 6
CH - Svizzera 6
ET - Etiopia 6
GE - Georgia 6
KG - Kirghizistan 6
PA - Panama 6
SN - Senegal 6
DO - Repubblica Dominicana 5
LB - Libano 5
BH - Bahrain 4
PS - Palestinian Territory 4
RO - Romania 4
RS - Serbia 4
TT - Trinidad e Tobago 4
AL - Albania 3
BG - Bulgaria 3
KW - Kuwait 3
MD - Moldavia 3
MN - Mongolia 3
NI - Nicaragua 3
PT - Portogallo 3
SK - Slovacchia (Repubblica Slovacca) 3
SR - Suriname 3
SY - Repubblica araba siriana 3
AM - Armenia 2
AO - Angola 2
BA - Bosnia-Erzegovina 2
DK - Danimarca 2
EU - Europa 2
GY - Guiana 2
HN - Honduras 2
HR - Croazia 2
NG - Nigeria 2
NZ - Nuova Zelanda 2
Totale 25.382
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Città #
Fairfield 1.099
Dallas 1.090
Ashburn 1.082
Singapore 1.072
Chandler 963
Woodbridge 843
Jacksonville 664
Hong Kong 635
San Jose 602
Nyköping 498
Houston 470
Seattle 416
Cambridge 402
Ann Arbor 394
Wilmington 376
Beijing 348
Roxbury 201
Lawrence 196
Nanjing 193
Lauterbourg 192
Bari 167
New York 161
Boardman 148
Los Angeles 139
Des Moines 138
Ho Chi Minh City 113
Council Bluffs 111
Brooklyn 107
Princeton 106
Helsinki 105
Dearborn 104
Santa Clara 88
São Paulo 79
Hanoi 73
Inglewood 62
Nanchang 60
Jakarta 59
Munich 59
Falkenstein 54
Buffalo 53
North Bergen 52
Hebei 51
San Diego 51
Jiaxing 50
Tokyo 50
Milan 48
Shenyang 48
Dublin 46
Chicago 43
Brussels 41
London 41
Dong Ket 39
Rio de Janeiro 37
San Francisco 36
Frankfurt am Main 35
Montreal 35
Atlanta 34
Marseille 34
Tianjin 34
Abidjan 30
Guangzhou 30
Paris 30
Nuremberg 29
Denver 28
Leawood 28
Moscow 28
San Mateo 28
Johannesburg 27
Warsaw 27
Augusta 26
Ardabil 23
Changsha 23
Orem 23
Baghdad 22
Shanghai 21
Stockholm 21
Belo Horizonte 20
Boston 20
Haiphong 20
Tashkent 20
Chennai 19
Washington 19
Istanbul 18
Jeddah 18
Jinan 18
Ankara 17
Brasília 17
Porto Alegre 17
Salvador 17
Amsterdam 16
Guayaquil 16
Kansas City 16
Mexico City 16
Poplar 16
Manchester 15
Medellín 15
Amman 14
Baku 14
Da Nang 14
Dhaka 14
Totale 15.377
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Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.089
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 216
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 205
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 202
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 198
Mind the Gap ! A Journey towards Computational Toxicology 190
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 188
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 185
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 183
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 182
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 180
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 180
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 176
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 174
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 171
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 169
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 168
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 168
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 167
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 166
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 165
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 163
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 162
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 162
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 161
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 160
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 158
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 157
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
Partitioning behaviour of piracetam-type cognition enhancers 156
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 156
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 152
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 151
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 148
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 146
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 146
Le applicazioni della chimica farmaceutica 145
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 145
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 144
Protein crystallography and fragment-based drug design 143
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 140
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 139
Advanced methodologies in medicinal chemistry research 136
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 136
Comparative Molecular Field Analysis (CoMFA) 136
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 136
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 135
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 134
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 134
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 134
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 133
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 133
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 133
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 133
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 131
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 131
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 130
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 129
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 128
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 126
Organofluorine-containing therapeutics for treatment of cardiovascular disease 126
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 125
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 125
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 125
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 124
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 123
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 123
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 122
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 122
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 120
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 119
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 119
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 118
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 118
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 117
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 116
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 116
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 116
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 116
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 114
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 114
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 113
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 113
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 112
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 112
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 111
Binding Models of Reversible Inhibitors to Monoamine Oxidases 107
Lipophilicity in Molecular Modeling of MAO Inhibitors. 107
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 107
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 107
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies 107
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 106
Determinazione del bilancio idrofilo-lipofilo di alcuni tensioattivi non-ionici mediante cromatografia planare in fase inversa 106
HIGHLY WATER-SOLUBLE DERIVATIVES OF THE ANESTHETIC AGENT PROPOFOL: IN VITRO AND IN VIVO EVALUATION OF CYCLIC AMINO ACID ESTERS 106
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 106
Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases 105
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 105
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 104
Wasserlossliche Medikamentenvorstufen von Propofol 104
Totale 14.870
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Categoria #
all - tutte 94.206
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 94.206
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021609 0 0 0 0 0 0 0 0 0 248 238 123
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20253.777 109 61 315 165 109 299 366 324 217 164 561 1.087
2025/20268.081 1.114 581 1.230 941 884 509 943 312 877 690 0 0
Totale 25.962