IRIS
ALTOMARE, Cosimo Damiano
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 11.183
EU - Europa 5.302
AS - Asia 4.509
SA - Sud America 1.055
AF - Africa 124
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 3
AN - Antartide 1
Totale 22.182
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 11.062
DE - Germania 2.078
SG - Singapore 1.829
CN - Cina 1.238
BR - Brasile 925
RU - Federazione Russa 715
SE - Svezia 714
HK - Hong Kong 622
IT - Italia 431
GB - Regno Unito 404
UA - Ucraina 304
VN - Vietnam 277
FI - Finlandia 219
FR - Francia 126
IN - India 116
ID - Indonesia 72
BD - Bangladesh 54
CA - Canada 54
ES - Italia 50
IR - Iran 48
AR - Argentina 47
TR - Turchia 47
IE - Irlanda 46
BE - Belgio 44
MX - Messico 44
NL - Olanda 42
JP - Giappone 35
PL - Polonia 35
CI - Costa d'Avorio 30
AT - Austria 26
EC - Ecuador 26
IQ - Iraq 26
ZA - Sudafrica 23
MA - Marocco 19
CZ - Repubblica Ceca 17
CO - Colombia 16
KR - Corea 15
PK - Pakistan 15
SA - Arabia Saudita 15
LT - Lituania 14
DZ - Algeria 12
UZ - Uzbekistan 11
VE - Venezuela 11
KE - Kenya 10
AZ - Azerbaigian 9
AE - Emirati Arabi Uniti 8
EG - Egitto 8
TN - Tunisia 8
JO - Giordania 7
PE - Perù 7
TH - Thailandia 7
UY - Uruguay 7
CL - Cile 6
CR - Costa Rica 6
IL - Israele 6
KZ - Kazakistan 6
NP - Nepal 6
OM - Oman 6
PH - Filippine 6
BY - Bielorussia 5
CH - Svizzera 5
ET - Etiopia 5
GE - Georgia 5
HU - Ungheria 5
BO - Bolivia 4
DO - Repubblica Dominicana 4
PY - Paraguay 4
TW - Taiwan 4
AU - Australia 3
BG - Bulgaria 3
BH - Bahrain 3
JM - Giamaica 3
MY - Malesia 3
PS - Palestinian Territory 3
PT - Portogallo 3
AL - Albania 2
AM - Armenia 2
BA - Bosnia-Erzegovina 2
EU - Europa 2
HR - Croazia 2
KG - Kirghizistan 2
KW - Kuwait 2
LB - Libano 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
PA - Panama 2
RO - Romania 2
SK - Slovacchia (Repubblica Slovacca) 2
SN - Senegal 2
SR - Suriname 2
TT - Trinidad e Tobago 2
AN - Antille olandesi 1
AO - Angola 1
BB - Barbados 1
BN - Brunei Darussalam 1
CG - Congo 1
EE - Estonia 1
GA - Gabon 1
GD - Grenada 1
GH - Ghana 1
Totale 22.170
Salva come PNG Salva come JPEG
Città #
Fairfield 1.099
Dallas 1.078
Chandler 963
Ashburn 920
Singapore 858
Woodbridge 843
Jacksonville 663
Hong Kong 606
Nyköping 498
Houston 467
Seattle 413
Cambridge 402
Ann Arbor 394
Wilmington 376
Beijing 335
Roxbury 201
Lawrence 196
Nanjing 193
Bari 163
New York 148
Boardman 145
Des Moines 137
Los Angeles 124
Princeton 105
Dearborn 104
Brooklyn 102
Ho Chi Minh City 92
Santa Clara 74
São Paulo 66
Inglewood 62
Nanchang 60
Munich 59
Jakarta 54
Hanoi 53
Buffalo 52
Hebei 51
San Diego 51
Helsinki 50
Jiaxing 50
North Bergen 50
Shenyang 48
Milan 46
Dublin 45
Brussels 40
Dong Ket 39
London 36
Chicago 35
Tianjin 34
Marseille 33
Rio de Janeiro 33
Council Bluffs 32
San Francisco 32
Abidjan 30
Guangzhou 30
Leawood 28
Montreal 28
San Mateo 28
Tokyo 28
Moscow 27
Augusta 26
Falkenstein 25
Nuremberg 25
Ardabil 23
Changsha 23
Frankfurt am Main 23
Warsaw 23
Atlanta 22
Paris 22
Shanghai 20
Belo Horizonte 19
Stockholm 19
Denver 18
Jinan 18
Johannesburg 18
Washington 18
Boston 17
Brasília 16
Kansas City 16
Ankara 15
Chennai 15
Porto Alegre 15
Redwood City 14
Salvador 14
The Dalles 14
Vienna 14
Zhengzhou 14
Florence 13
Poplar 13
Amsterdam 12
Columbus 12
Kunming 12
Ningbo 12
Wuxi 12
Goiânia 11
Hefei 11
Manchester 11
Monmouth Junction 11
Norwalk 11
Baghdad 10
Campinas 10
Totale 13.676
Salva come PNG Salva come JPEG
Nome #
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1 1.057
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 190
2-Phenylimidazo[1,2-a]pyridine-containing ligands of the 18-kDa translocator protein (TSPO) behave as agonists and antagonists of steroidogenesis in a mouse leydig tumor cell line. 180
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 178
Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones 177
Mind the Gap ! A Journey towards Computational Toxicology 173
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors 165
Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties 164
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 162
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 160
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 160
Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides 159
Mannich base approach to 5-methoxyisatin 3-(4-isopropylphenyl) hydrazone: a water-soluble prodrug for a multitarget inhibition of cholinesterases, beta-amyloid fibrillization and oligomer-induced cytotoxicity 154
Oxazepam-Dopamine Conjugates Increase Dopamine Delivery into Striatum of Intact Rats 154
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 153
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 153
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 152
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 150
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 150
New Azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity 150
Novel Antiproliferative Biphenyl Nicotinamide: NMR Metabolomic Study of its Effect on the MCF-7 Cell in Comparison with Cisplatin and Vinblastine 149
Structure-property relationship study of the HPLC enantio-selective retention of neuroprotective 7-[(1-alkylpiperidin-3-yl)methoxy]coumarin derivatives on an amylose-based chiral stationary phase 146
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 145
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 143
2-Benzazepine Nitrones Protect Dopaminergic Neurons against 6-Hydroxydopamine-Induced Oxidative Toxicity 143
3-benzazecine-based cyclic allene derivatives as highly potent P-glycoprotein inhibitors overcoming doxorubicin multidrug resistance 143
Partitioning behaviour of piracetam-type cognition enhancers 142
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 142
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 140
A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles 139
Protein crystallography and fragment-based drug design 137
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 135
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 132
Benzenesulfonamides Inhibitors of Carbonic Anhydrase: Study of Their Hydrophobicity by RPLC. QSAR: Quantitative Structure Activity Relationships 131
Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes 131
Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: Inhibitors of factor Xa and platelet aggregation 130
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 129
Propofol analogues. Synthesis, relationships between structure and affinity at GABAA receptor in rat brain, and differential electrophysiological profile at recombinant human GABAA receptors 129
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 129
Le applicazioni della chimica farmaceutica 128
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 128
Comparative Molecular Field Analysis (CoMFA) 127
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 125
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 125
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 125
Anticoagulant activity of new glycoconjugated inhibitors Of factor Xa and thrombin 125
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 125
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 124
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 124
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 124
High Affinity Central Benzodiazepine Receptor Ligands. Part 2: Quantitative Structure-Activity Relationships and Comparative Molecular Field Analysis of Pyrazolo[4,3-c]quinolin-3-ones 123
Advanced methodologies in medicinal chemistry research 122
An efficient Route to Biologically Active 5H-Indeno[1,2-c]Pyridazines 122
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 122
AZEPINO [4,3-b]INDOLE DERIVATIVES AS SELECTIVE INHIBITORS OF HUMAN BUTYRYLCHOLINESTERASE WITH PROTECTIVE EFFECTS AGAINST NMDA-INDUCED NEUROTOXICITY 122
Ester derivatives of annulated tetrahydroazocines: a new class of selective acetylcholinesterase inhibitors 121
Pharmaceutical development of novel lactate-based 6-fluoro-L-DOPA formulations 120
Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery 118
Organofluorine-containing therapeutics for treatment of cardiovascular disease 118
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 117
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 116
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 115
3D-QSAR models and docking studies of reversible inhibitors of type A and B Monoamine Oxidases 114
Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events 114
). A simple Synthesis of Heterocyclic Ring System Containing the 1,3-oxazine Nucleus 114
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor 113
Determination of hydrophile-lipophile balance of some polyethoxylated non-ionic surfactants by reversed-phase thin layer chromatography 112
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 111
Investigation on the antiplatelet activity of pyrrolo[3,2-c]pyridine-containing compounds 110
Nigral cell loss produced by infusion of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 110
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease 109
Benzenesulfonamide inhibitors of carbonic anhydrase: study of their hydrophobicity by RPLC. 109
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 108
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 108
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 107
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 106
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 104
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 104
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCCC 104
Studio dell’Idrolisi Chimica e Plasmatica di Aril-nipecotati ad Attività Gaba-mimetica Attraverso Analisi Regressionale 102
New organic nitrate-containing benzyloxy isonipecotanilide derivatives with vasodilatory and anti-platelet activity 102
Understanding of the MAO-A and B Reversible Inhibitory Activity and Selectivity by Using 3D Descriptors of Lipophilicity 101
Binding Models of Reversible Inhibitors to Monoamine Oxidases 101
Away from Flatness: Unprecedented Nitrogen-Bridged Cyclopenta[a]indene Derivatives as Novel Anti-Alzheimer Multitarget Agents 101
Lipophilicity in Molecular Modeling of MAO Inhibitors. 99
NOVEL GLUCOSE-CONJUGATED HIGHLY POTENT DUAL THROMBIN AND FACTOR Xa INHIBITORS AS POTENTIAL ANTITHROMBOTICS 99
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activity, QSARs, and 3-D QSARs 99
Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides 99
HIGHLY WATER-SOLUBLE DERIVATIVES OF THE ANESTHETIC AGENT PROPOFOL: IN VITRO AND IN VIVO EVALUATION OF CYCLIC AMINO ACID ESTERS 97
The Hydrogen Bonding of Drugs: its Experimental Determination and Role in Pharmakokinetics and Pharmacodynamics 96
Determinazione del bilancio idrofilo-lipofilo di alcuni tensioattivi non-ionici mediante cromatografia planare in fase inversa 95
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 95
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 95
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 94
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 94
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 93
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 93
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 93
Tandem cleavage of hydrogenated beta- and gamma-carbolines. New practical synthesis of tetrahydroazocino[4,5-b]indoles and tetrahydroazocino[5,4-b]indoles showing acetylcholinesterase inhibitory activity 92
Wasserlossliche Medikamentenvorstufen von Propofol 92
Totale 13.461
Salva come PNG Salva come JPEG
Categoria #
all - tutte 87.798
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 87.798
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.138 0 0 0 0 0 71 161 117 180 248 238 123
2021/20221.510 56 188 49 61 51 84 78 60 90 164 262 367
2022/20232.606 392 238 146 206 407 306 27 301 428 53 55 47
2023/20241.010 70 161 53 120 67 182 58 38 43 34 33 151
2024/20253.777 109 61 315 165 109 299 366 324 217 164 561 1.087
2025/20264.852 1.114 581 1.230 941 884 102 0 0 0 0 0 0
Totale 22.733