Distribuzione geografica
Continente #
NA - Nord America 10781
EU - Europa 3371
AS - Asia 1119
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 4
OC - Oceania 1
Totale 15285
Nazione #
US - Stati Uniti d'America 10770
DE - Germania 1259
CN - Cina 935
SE - Svezia 699
UA - Ucraina 412
FI - Finlandia 247
GB - Regno Unito 243
IT - Italia 175
RU - Federazione Russa 133
FR - Francia 70
VN - Vietnam 64
IE - Irlanda 56
BE - Belgio 41
IR - Iran 23
IN - India 22
JP - Giappone 21
TW - Taiwan 16
CA - Canada 8
TR - Turchia 8
NL - Olanda 7
KR - Corea 6
CH - Svizzera 5
DK - Danimarca 5
EU - Europa 4
GE - Georgia 4
RO - Romania 4
TH - Thailandia 4
ES - Italia 3
HK - Hong Kong 3
HU - Ungheria 3
MA - Marocco 3
AM - Armenia 2
BR - Brasile 2
CZ - Repubblica Ceca 2
ID - Indonesia 2
IQ - Iraq 2
KW - Kuwait 2
MX - Messico 2
PL - Polonia 2
AD - Andorra 1
AN - Antille olandesi 1
AR - Argentina 1
AT - Austria 1
BY - Bielorussia 1
DZ - Algeria 1
EC - Ecuador 1
IM - Isola di Man 1
JO - Giordania 1
KZ - Kazakistan 1
LU - Lussemburgo 1
MY - Malesia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PH - Filippine 1
PK - Pakistan 1
Totale 15285
Città #
Fairfield 1753
Woodbridge 1151
Chandler 1054
Jacksonville 954
Houston 780
Seattle 669
Ashburn 616
Wilmington 605
Cambridge 585
Nyköping 490
Ann Arbor 453
Nanjing 275
Roxbury 245
Lawrence 241
Des Moines 158
Princeton 150
Beijing 146
Boardman 132
Dearborn 99
Bari 83
Brooklyn 80
Shenyang 78
Hebei 73
Nanchang 72
San Diego 70
Inglewood 65
Dong Ket 59
Jiaxing 57
Dublin 56
Tianjin 41
Brussels 38
Marseille 35
Redwood City 29
Jinan 28
Changsha 26
Kansas City 23
Zhengzhou 23
Guangzhou 22
Ningbo 19
San Mateo 19
Augusta 17
Leawood 16
Paris 16
Taipei 16
Ardabil 14
London 14
Milan 14
Monmouth Junction 13
Norwalk 13
Auburn Hills 12
Hefei 11
Los Angeles 11
Kunming 10
Helsinki 9
Hangzhou 8
Wako 7
Boydton 6
Rome 6
Taizhou 6
Grafing 5
Gravina In Puglia 5
Hanoi 5
Lyngby 5
Mumbai 5
Sheffield 5
Salice Salentino 4
San Francisco 4
St Albans 4
Toronto 4
Asahi 3
Chengdu 3
Falls Church 3
Indiana 3
Istanbul 3
Lanzhou 3
Strasbourg 3
Xian 3
Cedar Knolls 2
Chaoyang 2
Cosenza 2
Düsseldorf 2
Fuzhou 2
Isfahan 2
Kuwait 2
Kyoto 2
La Canada Flintridge 2
Malden 2
Mountain View 2
Muenster 2
Napoli 2
New York 2
Salvador 2
Seoul 2
Simi Valley 2
Solon 2
Tokyo 2
Waanrode 2
Wuhan 2
Ahmedabad 1
Aktobe 1
Totale 11885
Nome #
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships 176
1,3-Dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships 171
Docking-based classification models for exploratory toxicology studies on high-quality estrogenic experimental data 138
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 135
BCR-ABL inhibitors in chronic myeloid leukemia: process chemistry and biochemical profile 118
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ40 aggregation in vitro 118
Mind the Gap ! A Journey towards Computational Toxicology 117
A simple Synthesis of Heterocyclic Ring Systems Containing the 1,3-oxazine Nucleus 116
Applicability Domain for QSAR models: where theory meets reality 112
Linear Solvation Energy Relationships in Reversed-Phase Liquid Chromatography. Examination of Deltabond C8 as Stationary Phase for Measuring Lipophilicity Parameters 110
Integration of QSAR models for bioconcentration suitable for REACH 109
X-Ray Crystal Structure, Partitioning Behavior and Molecular Modeling Study of Piracetam-type Nootropics: Insights into the Pharmacophore 109
Inhibition of α-ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 108
Partitioning behaviour of piracetam-type cognition enhancers 107
Exploring Basic Tail Modifications of Coumarin-based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-soluble, Brain-permeant Neuroprotective Multitarget Agents 106
Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase 105
Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds 104
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding 101
LFER and CoMFA studies on optical resolution of a-alkyl-a-aryloxyacetic acid methyl esters on DACH-DNB chiral stationary phase 100
A convenient synthesis of nitriles from primary amides under mild conditions 99
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: Proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity 99
Lipophilicity Measurements of Benzenesulfonamide Inhibitors of Carbonic Anhydrase by Reversed-phase HPLC 97
Effects of isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on mitochondrial respiration 96
Lipophilicity of teicoplanin antibiotics as assessed by reversed phase high-performance liquid chromatography: quantitative structure-property and structure-activity relationships 96
Determination of Lipophilicity and Hydrogen-bond Donor Acidity of Bioactive Sulphonyl-containing Compounds by Reversed-phase HPLC and Centrifugal Partition Chromatography and their Application to Structure-activity Relations 96
Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways 94
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases 94
Pyrrolo(3,2-c)pyridine derivatives as inhibitors of platelet aggregation 92
Synthesis and antibacterial activity of 2-aryl-2,5-dihydro-3(3H)-oxo-pyridazino4,3-bindole-4-carboxylic acids 92
Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor 92
Synthesis and antibacterial activity of pyridazino[4,3-b]indole-4-carboxylic acids carrying different substituents at N-2 91
Synthesis of 12-mono- and di-substituted 8-aza-11-oxasteroids 91
Insights into the complex formed by Matrix Metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations 91
QSAR Analysis of the Subtilisin Hydrolysis of X-Phenyl-Hippurates II. A Study of Subtilisin BPN' 90
In Silico Design of Novel 2H-Chromen-2-one Derivatives as Potent and Selective MAO-B Inhibitors 90
The practice of medicinal chemistry 90
2-(2-Phenylcyclopropyl)-Imidazolines: Reversed Enantioselective Interaction At I1 and I2 Imidazoline Receptors 90
D184E mutation in aquaporin-4 gene impairs water permeability and links to deafness. 90
Ligands of neuronal nicotinic acetylcholine receptor (nAChR): inferences from the Hansch and 3-D Quantitative Structure-Activity Relationship (QSAR) models 89
On the Catalytic Reduction of Some 12-spiro-derivatives of 8-aza-11-oxasteroids 89
Reduction of Aldol Adducts from 1,2,3-Indantrione and Cyclic CH-acid Compounds; Keto-enol Tautomeric Study of Reduction Products 89
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors 88
Carbamate Prodrug Concept for Hydroxamate HDAC Inhibitors 86
Investigation on platelet aggregation inhibitory activity by phenyl amides and esters of piperidinecarboxylic acids 86
Neuronal nicotinic acetylcholine receptor agonists: Pharmacophores, evolutionary QSAR and 3D-QSAR models 86
Heterocyclic Steroids II. Synthesis of Some Spiro-Derivatives of 7,8-Diaza-11-Oxasteroids 86
Searching for Multitargeting Neurotherapeutics against Alzheimer's: Discovery of Potent AChE−MAO B Inhibitors through the Decoration of 2H-Chromen-2-one Structural Motif 86
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase 86
Potent inhibitors of human LAT1 (SLC7A5) transporter based on dithiazole and dithiazine compounds for development of anticancer drugs 86
Studies on the antiplatelet and antithrombotic profile of anti-inflammatory coumarin derivatives 86
A simple and Mild Procedure for the Preparation of Bile Acid Methyl Esters 85
Building up QSAR model for toxicity of Psychotropic Drugs by the Monte Carlo method 85
Le applicazioni della chimica farmaceutica 85
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents 85
Synthesis.and biological evaluation of pyridazino[4,3-b]indoles and indeno[1,2-c]pyridazines as new ligands of central and peripheral benzodiazepine receptors 85
Coumarin, chromone, and 4(3H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis 84
Actinidin hydrolysis of substituted-phenyl hippurates: a quantitative structure-activity relationship and graphics comparison with hydrolysis by papain 83
Synthesis of potential dual binding site acetylcholinesterase inhibitors through an efficient solid phase approach based on Mitsunobu reaction 83
Folding In Lipid Membranes (FILM): a novel method for the prediction of small membrane protein 3D structures 82
null 81
An easy, high-yield conversion of aldoximes to nitriles 81
Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases 81
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6′-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N- methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors 81
Sintesi di sistemi eterociclici a potenziale attivita farmacologica contenenti un nucleo 1,3-ossazinico 80
Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties 80
Assessment of Hydrogen-bond Donor Acidity of Bioactive Sulfonyl-containing Compounds by CCC 79
Tetraoxoderivatives of Perhydropyrrolo[3,4-c]pyridine 79
Enantiomeric Resolution of Sulfoxides on a DACH-DNB Chiral Stationary Phase: a Quantitative Structure-Enantioselective Retention Relationship (QSERR) Study 79
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9 79
Computer Aided Structure Based Design of Multitarget Leads for Alzheimer’s Disease 79
Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs 79
Inhibition of MAO by functionalized coumarin derivatives: Biological activities, QSARs and 3D QSARs 77
Fine Molecular Tuning at Position 4 of 2H-Chromen-2-one Derivatives in the Search of Potent and Selective Monoamine Oxidase B Inhibitors 77
An alternative QSAR-based approach for predicting the bioconcentration factor for regulatory purposes 76
Theoretical Quantitative Structure-Activity Analysis of Quinuclidine-Based Muscarinic Cholinergic Receptor Ligands 75
Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams 75
Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 75
17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting both the Human Enzyme and its Murine Ortholog 75
8-Aminomethyl-7-hydroxy-4-methylcoumarins as Multitarget Leads for Alzheimer's Disease 75
Design, Synthesis, and 3D QSAR of Novel Potent and Selective Aromatase Inhibitors 73
REACH and in silico methods: an attractive opportunity for medicinal chemists 73
High affinity central benzodiazepine receptor ligands: synthesis and structure-activity relationship studies of a new series of pyrazolo[4,3-c]quinolin-3-ones. 72
Estimation of partitioning parameters of nonionic surfactants using calculated descriptors of molecular size, polarity, and hydrogen bonding. 72
Synthesis and structure-affinity relationships at the central benzodiazepine receptor of pyridazino4,3-bindoles and indeno1,2-cpyridazines 72
Synthesis and anticonvulsant activity of some 1,2,3,3a-tetrahydropyrrolo[2,1-b]-benzothiazol-, -thiazol- or -oxazol-1-ones in rodents. 72
Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models. 72
Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model 71
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells 71
Advanced methodologies in medicinal chemistry research 71
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. 70
Novel, potent and selective 17b-hydroxysteroid dehydrogenase type 2-inhibitors as potential therapeutics for osteoporosis with dual human and mouse activities 69
Strategies of multi-objective optimization in drug discovery and development 69
Papain catalyzed hydrolysis of aryl esters: a comparison of the Hansch, Docking and CoMFA methods 69
Neuronal Nicotinic Agonists: a Multi-approach Development of the Pharmacophore 69
A Round Trip from Medicinal Chemistry to Predictive Toxicology 69
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties 69
Addressing cytotoxicity of 1,4-biphenyl amide derivatives: discovery of new potent and selective 17β-hydroxysteroid dehydrogenase type 2 inhibitors 69
QSAR of Teicoplanin Antibiotics: Influence of Lipophilicity and Ionic Properties on their in vivo Antimicrobial Activity 68
Totale 8891
Categoria #
all - tutte 29500
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29500

Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2017/2018205 0000 00 00 0686275
2018/20192230 63117819 78208 3065 69257632720
2019/20204292 747275133450 428298 462354 49721633597
2020/20212341 253169169163 255110 188144 194325198173
2021/20221665 692421398 7780 9484 96166296350
2022/20232779 474198148285 432362 26323 531000
Totale 15547