IRIS
PURGATORIO, ROSA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 2.600
AS - Asia 1.450
EU - Europa 1.116
SA - Sud America 399
AF - Africa 82
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 5.654
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.532
SG - Singapore 546
BR - Brasile 318
CN - Cina 290
IT - Italia 252
SE - Svezia 183
RU - Federazione Russa 182
HK - Hong Kong 165
VN - Vietnam 134
DE - Germania 132
FR - Francia 88
GB - Regno Unito 77
IN - India 66
FI - Finlandia 45
BD - Bangladesh 39
ID - Indonesia 34
CA - Canada 30
AR - Argentina 28
BE - Belgio 26
JP - Giappone 25
ES - Italia 23
TR - Turchia 23
CI - Costa d'Avorio 22
NL - Olanda 22
PL - Polonia 20
MX - Messico 19
ZA - Sudafrica 18
UA - Ucraina 16
VE - Venezuela 16
AT - Austria 15
IQ - Iraq 15
IR - Iran 15
EC - Ecuador 13
MA - Marocco 11
PH - Filippine 11
KR - Corea 10
CO - Colombia 8
EG - Egitto 8
PE - Perù 8
PK - Pakistan 8
SA - Arabia Saudita 8
MY - Malesia 7
TW - Taiwan 7
AE - Emirati Arabi Uniti 6
CL - Cile 6
CZ - Repubblica Ceca 6
DZ - Algeria 6
IE - Irlanda 6
TN - Tunisia 6
AU - Australia 5
ET - Etiopia 5
IL - Israele 5
LT - Lituania 5
UZ - Uzbekistan 5
JO - Giordania 4
KE - Kenya 4
NP - Nepal 4
TT - Trinidad e Tobago 4
CH - Svizzera 3
CR - Costa Rica 3
DK - Danimarca 3
JM - Giamaica 3
KG - Kirghizistan 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
TH - Thailandia 3
AZ - Azerbaigian 2
BG - Bulgaria 2
BH - Bahrain 2
BY - Bielorussia 2
EE - Estonia 2
KW - Kuwait 2
KZ - Kazakistan 2
NI - Nicaragua 2
OM - Oman 2
SY - Repubblica araba siriana 2
BN - Brunei Darussalam 1
BO - Bolivia 1
DO - Repubblica Dominicana 1
EU - Europa 1
GD - Grenada 1
GE - Georgia 1
HN - Honduras 1
KH - Cambogia 1
LB - Libano 1
LK - Sri Lanka 1
MK - Macedonia 1
MW - Malawi 1
NG - Nigeria 1
PR - Porto Rico 1
PY - Paraguay 1
RO - Romania 1
RS - Serbia 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 5.654
Salva come PNG Salva come JPEG
Città #
Ashburn 327
Singapore 288
Chandler 234
Fairfield 165
San Jose 157
Hong Kong 154
Nyköping 141
Ann Arbor 103
Houston 92
Beijing 85
Bari 76
Woodbridge 74
Seattle 71
Cambridge 69
Council Bluffs 65
Dallas 64
Wilmington 61
New York 54
Lauterbourg 41
Ho Chi Minh City 40
Roxbury 39
Helsinki 37
Los Angeles 35
Falkenstein 33
Lawrence 31
Brooklyn 30
Hanoi 29
North Bergen 28
São Paulo 28
Munich 27
Brussels 26
Jacksonville 26
Dearborn 25
Boardman 24
Jakarta 24
Des Moines 23
Moscow 23
Santa Clara 23
Abidjan 22
Tokyo 21
Milan 20
Nuremberg 17
San Diego 17
Inglewood 14
Warsaw 14
Frankfurt am Main 13
Montreal 13
Nanjing 13
Paris 12
Buffalo 10
Chicago 10
Johannesburg 10
Poplar 10
Stockholm 10
West Jordan 10
Amsterdam 9
Atlanta 9
Boston 9
Chennai 9
Orem 9
The Dalles 9
Vienna 9
Columbus 8
Denver 8
London 8
Rome 8
San Francisco 8
Sannicandro di Bari 8
Tehran 8
Belo Horizonte 7
Delhi 7
Dong Ket 7
Marseille 7
Nanchang 7
Phoenix 7
Porto Alegre 7
Rio de Janeiro 7
Santa Marinella 7
Shanghai 7
Baghdad 6
Buenos Aires 6
Da Nang 6
Dublin 6
Guangzhou 6
Haiphong 6
Istanbul 6
Leawood 6
Mexico City 6
New Delhi 6
Princeton 6
Salt Lake City 6
Brasília 5
Campinas 5
Fragagnano 5
Kansas City 5
Kolkata 5
Manchester 5
Quito 5
São José dos Campos 5
Addis Ababa 4
Totale 3.413
Salva come PNG Salva come JPEG
Nome #
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 220
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 216
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 202
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 188
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 180
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 180
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 178
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 171
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 162
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 156
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 153
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 148
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 140
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 140
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 123
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 117
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 114
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 113
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 106
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 104
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 104
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 104
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 101
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 96
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 96
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 93
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 93
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 92
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 91
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 90
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 89
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 85
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 84
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 80
Molecular Mechanisms of Learning and Memory 80
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 79
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 75
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 75
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 72
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 71
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 66
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 64
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 58
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 57
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 57
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 56
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 54
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 52
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 50
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 48
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 47
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 46
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 42
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 38
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 31
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 28
null 27
Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency 25
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 25
null 25
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 24
A second life for MAO inhibitors: from CNS diseases to cancer 23
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 20
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 20
The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey 15
Investigating Amphoteric 3,4′-Biscoumarin-Based ortho-[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors 11
Investigating the multi-target potential for complex diseases of the alkaloidcontaining pyrrolo[2,1-a]isoquinoline scaffold 11
Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT7 receptor antagonists as compounds used to treat Alzheimer's disease symptoms 10
Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines 9
Totale 5.900
Salva come PNG Salva come JPEG
Categoria #
all - tutte 24.216
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 24.216
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202198 0 0 0 0 0 0 0 0 0 35 38 25
2021/2022377 11 22 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/20251.130 39 27 73 56 41 83 172 112 84 43 167 233
2025/20262.426 337 142 189 287 322 199 292 119 324 215 0 0
Totale 5.900