IRIS
PURGATORIO, ROSA
 Distribuzione geografica
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Continente #
NA - Nord America 3.035
AS - Asia 1.514
EU - Europa 1.388
SA - Sud America 407
Continente sconosciuto - Info sul continente non disponibili 263
AF - Africa 82
OC - Oceania 5
Totale 6.694
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Nazione #
US - Stati Uniti d'America 2.950
SG - Singapore 550
IT - Italia 513
BR - Brasile 320
CN - Cina 310
SE - Svezia 185
RU - Federazione Russa 182
HK - Hong Kong 171
VN - Vietnam 133
DE - Germania 132
FR - Francia 88
GB - Regno Unito 76
IN - India 69
BD - Bangladesh 57
FI - Finlandia 45
CA - Canada 39
ID - Indonesia 34
AR - Argentina 30
JP - Giappone 27
BE - Belgio 26
ES - Italia 23
CI - Costa d'Avorio 22
NL - Olanda 22
PL - Polonia 22
TR - Turchia 22
MX - Messico 18
UA - Ucraina 18
ZA - Sudafrica 18
VE - Venezuela 16
AT - Austria 15
IQ - Iraq 15
IR - Iran 15
EC - Ecuador 14
PH - Filippine 13
MA - Marocco 11
PK - Pakistan 11
CO - Colombia 10
KR - Corea 10
EG - Egitto 8
PE - Perù 8
SA - Arabia Saudita 8
CL - Cile 7
CZ - Repubblica Ceca 7
IE - Irlanda 7
MY - Malesia 7
TW - Taiwan 7
AE - Emirati Arabi Uniti 6
CR - Costa Rica 6
DZ - Algeria 6
TH - Thailandia 6
AU - Australia 5
ET - Etiopia 5
IL - Israele 5
JM - Giamaica 5
LT - Lituania 5
TN - Tunisia 5
UZ - Uzbekistan 5
JO - Giordania 4
KE - Kenya 4
KZ - Kazakistan 4
NP - Nepal 4
TT - Trinidad e Tobago 4
AZ - Azerbaigian 3
CH - Svizzera 3
DK - Danimarca 3
EE - Estonia 3
KG - Kirghizistan 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
BG - Bulgaria 2
BH - Bahrain 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
KW - Kuwait 2
NI - Nicaragua 2
OM - Oman 2
RO - Romania 2
RS - Serbia 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
BB - Barbados 1
BO - Bolivia 1
BW - Botswana 1
DO - Repubblica Dominicana 1
EU - Europa 1
GD - Grenada 1
GE - Georgia 1
GT - Guatemala 1
HN - Honduras 1
HT - Haiti 1
KH - Cambogia 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MK - Macedonia 1
MW - Malawi 1
NG - Nigeria 1
PR - Porto Rico 1
PY - Paraguay 1
Totale 6.432
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Città #
Ashburn 354
Singapore 288
Chandler 234
San Jose 232
Fairfield 165
Milan 162
Hong Kong 159
Nyköping 141
Council Bluffs 126
Ann Arbor 103
Beijing 94
Houston 93
Bari 77
Woodbridge 74
Seattle 71
Cambridge 69
Dallas 69
New York 64
Wilmington 63
Boardman 56
Rome 43
Lauterbourg 41
Ho Chi Minh City 40
Santa Clara 40
Los Angeles 39
Roxbury 39
Helsinki 37
Falkenstein 33
Lawrence 31
Brooklyn 30
Hanoi 29
North Bergen 28
São Paulo 28
Munich 27
Brussels 26
Jacksonville 26
Columbus 25
Dearborn 25
Jakarta 24
Des Moines 23
Moscow 23
Abidjan 22
Tokyo 21
Montreal 18
San Diego 18
Nuremberg 17
Buffalo 15
Phoenix 15
Chicago 14
Inglewood 14
Warsaw 14
Figino 13
Frankfurt am Main 13
Nanjing 13
Paris 12
Atlanta 11
Orem 11
Boston 10
Johannesburg 10
Kansas City 10
Poplar 10
San Francisco 10
Stockholm 10
West Jordan 10
Amsterdam 9
The Dalles 9
Vienna 9
Chennai 8
Denver 8
London 8
Sannicandro di Bari 8
Tehran 8
Belo Horizonte 7
Delhi 7
Dong Ket 7
Dublin 7
Marseille 7
Nanchang 7
New Delhi 7
Porto Alegre 7
Rio de Janeiro 7
Santa Marinella 7
Shanghai 7
Baghdad 6
Bologna 6
Buenos Aires 6
Da Nang 6
Florence 6
Genoa 6
Guangzhou 6
Haiphong 6
Leawood 6
Mexico City 6
Philadelphia 6
Princeton 6
Quito 6
Salt Lake City 6
Turin 6
Boydton 5
Brasília 5
Totale 3.906
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Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 254
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 241
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 219
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 204
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 200
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 198
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 194
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 193
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 182
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 168
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 164
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 163
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 154
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 152
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 130
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 128
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 124
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 122
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 121
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 118
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 116
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 115
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 114
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 114
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 110
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 107
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 107
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 107
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 105
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 105
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 98
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 96
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 96
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 91
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 89
Molecular Mechanisms of Learning and Memory 87
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 85
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 83
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 83
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 79
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 77
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 76
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 74
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 73
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 73
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 70
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 69
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 57
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 57
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 55
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 54
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 53
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 50
A second life for MAO inhibitors: from CNS diseases to cancer 43
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 43
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 42
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 42
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 37
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 29
Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency 28
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The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 24
Investigating the multi-target potential for complex diseases of the alkaloidcontaining pyrrolo[2,1-a]isoquinoline scaffold 22
The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey 20
Investigating Amphoteric 3,4′-Biscoumarin-Based ortho-[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors 18
Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT7 receptor antagonists as compounds used to treat Alzheimer's disease symptoms 15
Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines 14
Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities 11
Totale 6.694
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Categoria #
all - tutte 27.560
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.560
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022344 0 0 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/20251.130 39 27 73 56 41 83 172 112 84 43 167 233
2025/20262.855 337 142 189 286 308 195 291 117 321 245 117 307
2026/2027365 111 158 96 0 0 0 0 0 0 0 0 0
Totale 6.694