IRIS
PURGATORIO, ROSA
 Distribuzione geografica
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Continente #
NA - Nord America 3.480
AS - Asia 1.528
EU - Europa 1.442
SA - Sud America 415
Continente sconosciuto - Info sul continente non disponibili 270
AF - Africa 85
OC - Oceania 6
Totale 7.226
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Nazione #
US - Stati Uniti d'America 3.332
SG - Singapore 552
IT - Italia 542
BR - Brasile 325
CN - Cina 310
RU - Federazione Russa 187
SE - Svezia 185
HK - Hong Kong 171
DE - Germania 136
VN - Vietnam 133
FR - Francia 90
GB - Regno Unito 85
IN - India 69
CA - Canada 65
BD - Bangladesh 57
FI - Finlandia 45
ID - Indonesia 34
AR - Argentina 31
JP - Giappone 28
BE - Belgio 26
ES - Italia 23
NL - Olanda 23
PL - Polonia 23
CI - Costa d'Avorio 22
TR - Turchia 22
MX - Messico 20
ZA - Sudafrica 19
UA - Ucraina 18
IQ - Iraq 16
VE - Venezuela 16
AT - Austria 15
EC - Ecuador 15
IR - Iran 15
IL - Israele 13
PH - Filippine 13
TT - Trinidad e Tobago 12
CO - Colombia 11
CR - Costa Rica 11
MA - Marocco 11
PK - Pakistan 11
KR - Corea 10
EG - Egitto 8
PE - Perù 8
SA - Arabia Saudita 8
CL - Cile 7
CZ - Repubblica Ceca 7
IE - Irlanda 7
MY - Malesia 7
TW - Taiwan 7
AE - Emirati Arabi Uniti 6
CW - ???statistics.table.value.countryCode.CW??? 6
DZ - Algeria 6
JM - Giamaica 6
LT - Lituania 6
TH - Thailandia 6
AU - Australia 5
EE - Estonia 5
ET - Etiopia 5
GP - Guadalupe 5
KZ - Kazakistan 5
SV - El Salvador 5
TN - Tunisia 5
UZ - Uzbekistan 5
GT - Guatemala 4
HN - Honduras 4
JO - Giordania 4
KE - Kenya 4
NI - Nicaragua 4
NP - Nepal 4
AZ - Azerbaigian 3
CH - Svizzera 3
DK - Danimarca 3
KG - Kirghizistan 3
PA - Panama 3
PR - Porto Rico 3
SK - Slovacchia (Repubblica Slovacca) 3
BG - Bulgaria 2
BH - Bahrain 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
KW - Kuwait 2
OM - Oman 2
RO - Romania 2
RS - Serbia 2
SC - Seychelles 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
BB - Barbados 1
BO - Bolivia 1
BW - Botswana 1
DO - Repubblica Dominicana 1
EU - Europa 1
FJ - Figi 1
GD - Grenada 1
GE - Georgia 1
HT - Haiti 1
KH - Cambogia 1
LB - Libano 1
LK - Sri Lanka 1
Totale 6.956
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Città #
Ashburn 444
Singapore 288
San Jose 271
Chandler 234
Fairfield 165
Milan 164
Hong Kong 159
Nyköping 141
Council Bluffs 130
Ann Arbor 103
Beijing 94
Houston 93
Bari 79
Woodbridge 74
Dallas 73
Seattle 72
New York 70
Cambridge 69
Wilmington 63
Boardman 57
Santa Clara 50
Rome 44
Los Angeles 43
Lauterbourg 41
Ho Chi Minh City 40
Roxbury 39
Helsinki 37
Falkenstein 33
North Bergen 33
Brooklyn 32
Lawrence 31
São Paulo 31
Hanoi 29
Munich 27
Washington 27
Brussels 26
Jacksonville 26
Columbus 25
Dearborn 25
Jakarta 24
Des Moines 23
Moscow 23
Abidjan 22
Tokyo 22
Montreal 20
Phoenix 19
Nuremberg 18
San Diego 18
Atlanta 16
Buffalo 16
Chicago 15
Warsaw 15
Inglewood 14
Boston 13
Figino 13
Frankfurt am Main 13
Nanjing 13
Paris 12
London 11
Orem 11
San Francisco 11
Johannesburg 10
Kansas City 10
Poplar 10
Stockholm 10
West Jordan 10
Amsterdam 9
Denver 9
San José 9
The Dalles 9
Vienna 9
Chennai 8
Miami 8
Sannicandro di Bari 8
Tehran 8
Turin 8
Belo Horizonte 7
Delhi 7
Dong Ket 7
Dublin 7
Marseille 7
Nanchang 7
Naples 7
New Delhi 7
Porto Alegre 7
Quito 7
Rio de Janeiro 7
Santa Marinella 7
Shanghai 7
Toronto 7
Baghdad 6
Bologna 6
Buenos Aires 6
Da Nang 6
Florence 6
Genoa 6
Guangzhou 6
Haiphong 6
Leawood 6
Mexico City 6
Totale 4.137
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Nome #
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 262
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 249
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 228
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 214
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 205
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 204
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 202
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 201
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 190
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 179
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 176
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 168
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 160
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 155
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 135
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 133
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 133
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 132
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 129
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 128
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 124
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 121
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 121
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 120
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 116
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 116
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 115
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 113
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 112
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 111
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 104
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 103
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 102
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 100
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 96
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 93
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 90
Molecular Mechanisms of Learning and Memory 90
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 89
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 87
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 86
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 84
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 80
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 79
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 79
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 78
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 72
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 66
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 65
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 63
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 61
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 55
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 54
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 53
A second life for MAO inhibitors: from CNS diseases to cancer 51
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 51
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 50
Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency 47
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 42
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 42
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 33
Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities 32
The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey 32
Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT7 receptor antagonists as compounds used to treat Alzheimer's disease symptoms 30
Investigating the multi-target potential for complex diseases of the alkaloidcontaining pyrrolo[2,1-a]isoquinoline scaffold 29
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Investigating Amphoteric 3,4′-Biscoumarin-Based ortho-[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors 24
Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines 23
PROTAC-Based Strategies in Neurodegenerative Diseases: Challenges and Perspectives 7
Totale 7.226
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Categoria #
all - tutte 29.192
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 29.192
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022303 0 0 0 0 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/20251.130 39 27 73 56 41 83 172 112 84 43 167 233
2025/20262.855 337 142 189 286 308 195 291 117 321 245 117 307
2026/2027897 111 158 217 372 39 0 0 0 0 0 0 0
Totale 7.226