IRIS
PURGATORIO, ROSA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 1.552
EU - Europa 569
AS - Asia 297
AF - Africa 7
SA - Sud America 5
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 2.432
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 1.549
SE - Svezia 172
IT - Italia 155
CN - Cina 137
SG - Singapore 89
DE - Germania 47
RU - Federazione Russa 36
GB - Regno Unito 33
IN - India 32
BE - Belgio 24
FI - Finlandia 24
FR - Francia 22
ES - Italia 13
IR - Iran 13
NL - Olanda 12
UA - Ucraina 12
VN - Vietnam 7
IE - Irlanda 5
TR - Turchia 5
CZ - Repubblica Ceca 4
JP - Giappone 4
MA - Marocco 4
BR - Brasile 3
CA - Canada 3
KR - Corea 3
TW - Taiwan 3
CH - Svizzera 2
DK - Danimarca 2
EG - Egitto 2
HK - Hong Kong 2
LT - Lituania 2
PL - Polonia 2
AR - Argentina 1
AT - Austria 1
AU - Australia 1
BG - Bulgaria 1
EU - Europa 1
IL - Israele 1
NG - Nigeria 1
NP - Nepal 1
PE - Perù 1
Totale 2.432
Salva come PNG Salva come JPEG
Città #
Chandler 234
Fairfield 165
Nyköping 141
Ashburn 123
Ann Arbor 103
Houston 86
Woodbridge 74
Cambridge 69
Singapore 69
Seattle 66
Bari 65
Wilmington 58
Roxbury 39
Lawrence 31
Jacksonville 26
New York 26
Dearborn 25
Brussels 24
Brooklyn 23
Des Moines 23
Boardman 21
Helsinki 17
San Diego 17
Milan 15
Beijing 14
Inglewood 14
Nanjing 13
Munich 11
West Jordan 10
Santa Clara 9
Paris 8
Dong Ket 7
Marseille 7
Nanchang 7
Santa Marinella 7
Leawood 6
Princeton 6
Tehran 6
Dublin 5
Guangzhou 5
Kolkata 5
Moscow 5
Brno 4
Delhi 4
Guwahati 4
Jiaxing 4
Kansas City 4
Los Angeles 4
Rome 4
Romola 4
Shanghai 4
Shenyang 4
St Albans 4
Washington 4
Weihai 4
Wuxi 4
Zhengzhou 4
Almere Stad 3
Azrou 3
Bhubaneswar 3
Boydton 3
Hebei 3
Jinhua 3
London 3
New Delhi 3
Norwalk 3
Visakhapatnam 3
Amsterdam 2
Arezzo 2
Arzano 2
Changsha 2
Copenhagen 2
Daejeon 2
Delft 2
Fuzhou 2
Hefei 2
Hounslow 2
Ismailia 2
Jinan 2
Konya 2
Lucknow 2
Lugano 2
Madrid 2
Mola di Bari 2
Morādābād 2
Ningbo 2
Nürnberg 2
Osaka 2
Pescara 2
San Francisco 2
San Mateo 2
Sannicandro di Bari 2
Taichung 2
Taiyuan 2
Warsaw 2
Wuhan 2
Acton 1
Ardabil 1
Arequipa 1
Augusta 1
Totale 1.837
Salva come PNG Salva come JPEG
Nome #
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 143
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 134
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 125
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 124
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 124
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 109
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 98
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 94
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 78
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 74
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 74
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 73
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 70
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 70
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 70
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 69
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 69
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 64
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 62
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 61
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 57
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 55
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 53
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 51
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 50
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 49
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 46
Molecular Mechanisms of Learning and Memory 43
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 36
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 29
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 29
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 29
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 28
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 28
null 27
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 27
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 26
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 26
null 25
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 20
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 13
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 13
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 12
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 10
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 10
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 9
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 8
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 7
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 7
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 7
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 6
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 5
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 5
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 4
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 4
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 3
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 2
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 1
Totale 2.645
Salva come PNG Salva come JPEG
Categoria #
all - tutte 14.067
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 14.067
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020241 0 0 0 0 0 40 54 37 41 32 26 11
2020/2021439 26 17 20 19 30 24 133 37 35 35 38 25
2021/2022377 11 22 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/2025301 39 27 73 56 41 65 0 0 0 0 0 0
Totale 2.645