IRIS
PURGATORIO, ROSA
 Distribuzione geografica
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Continente #
NA - Nord America 2.214
AS - Asia 1.162
EU - Europa 937
SA - Sud America 301
AF - Africa 57
Continente sconosciuto - Info sul continente non disponibili 2
OC - Oceania 2
Totale 4.675
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Nazione #
US - Stati Uniti d'America 2.167
SG - Singapore 458
BR - Brasile 260
CN - Cina 244
IT - Italia 183
SE - Svezia 183
RU - Federazione Russa 173
HK - Hong Kong 151
DE - Germania 114
VN - Vietnam 105
GB - Regno Unito 71
IN - India 49
FR - Francia 41
FI - Finlandia 30
ID - Indonesia 27
BE - Belgio 25
CA - Canada 23
CI - Costa d'Avorio 22
ES - Italia 21
AR - Argentina 20
NL - Olanda 20
BD - Bangladesh 18
JP - Giappone 18
PL - Polonia 16
AT - Austria 15
IR - Iran 15
UA - Ucraina 15
MX - Messico 13
TR - Turchia 11
ZA - Sudafrica 10
IQ - Iraq 9
KR - Corea 8
CZ - Repubblica Ceca 6
EC - Ecuador 6
IE - Irlanda 6
MA - Marocco 6
EG - Egitto 5
IL - Israele 5
LT - Lituania 5
PE - Perù 5
PK - Pakistan 5
SA - Arabia Saudita 5
TW - Taiwan 5
UZ - Uzbekistan 5
VE - Venezuela 5
AE - Emirati Arabi Uniti 4
ET - Etiopia 4
TN - Tunisia 4
CO - Colombia 3
JO - Giordania 3
AU - Australia 2
BG - Bulgaria 2
BY - Bielorussia 2
CH - Svizzera 2
CL - Cile 2
CR - Costa Rica 2
DK - Danimarca 2
DZ - Algeria 2
EE - Estonia 2
KE - Kenya 2
MY - Malesia 2
NP - Nepal 2
OM - Oman 2
PA - Panama 2
PH - Filippine 2
SK - Slovacchia (Repubblica Slovacca) 2
TT - Trinidad e Tobago 2
AZ - Azerbaigian 1
BH - Bahrain 1
BN - Brunei Darussalam 1
EU - Europa 1
GD - Grenada 1
GE - Georgia 1
HN - Honduras 1
JM - Giamaica 1
KG - Kirghizistan 1
KW - Kuwait 1
KZ - Kazakistan 1
LB - Libano 1
MK - Macedonia 1
MW - Malawi 1
NG - Nigeria 1
NI - Nicaragua 1
PR - Porto Rico 1
SY - Repubblica araba siriana 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 4.675
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Città #
Ashburn 289
Chandler 234
Singapore 225
Fairfield 165
Hong Kong 147
Nyköping 141
Ann Arbor 103
Houston 91
Beijing 78
Woodbridge 74
Bari 73
Seattle 70
Cambridge 69
Dallas 61
Wilmington 61
New York 46
Roxbury 39
Ho Chi Minh City 32
Lawrence 31
Brooklyn 30
Los Angeles 30
North Bergen 28
Munich 27
Jacksonville 26
Brussels 25
Dearborn 25
Hanoi 24
Boardman 23
Des Moines 23
Falkenstein 23
Jakarta 23
Abidjan 22
Council Bluffs 22
Helsinki 22
Moscow 22
São Paulo 22
Milan 17
Nuremberg 17
San Diego 17
Santa Clara 15
Inglewood 14
Tokyo 14
Montreal 13
Nanjing 13
Warsaw 13
San Jose 12
Stockholm 10
West Jordan 10
Boston 9
Buffalo 9
Paris 9
Poplar 9
The Dalles 9
Vienna 9
Amsterdam 8
Johannesburg 8
London 8
Tehran 8
Atlanta 7
Belo Horizonte 7
Chennai 7
Chicago 7
Columbus 7
Denver 7
Dong Ket 7
Frankfurt am Main 7
Marseille 7
Nanchang 7
Phoenix 7
San Francisco 7
Santa Marinella 7
Dublin 6
Guangzhou 6
Leawood 6
New Delhi 6
Princeton 6
Rome 6
Buenos Aires 5
Campinas 5
Da Nang 5
Delhi 5
Fragagnano 5
Kansas City 5
Kolkata 5
Mexico City 5
Orem 5
Porto Alegre 5
Rio de Janeiro 5
Shanghai 5
São José dos Campos 5
Brasília 4
Brno 4
Düsseldorf 4
Guwahati 4
Haiphong 4
Jiaxing 4
Manchester 4
Romola 4
Roubaix 4
Santo André 4
Totale 2.929
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Nome #
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 204
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 192
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 181
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 167
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 166
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 165
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 164
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 144
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 143
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 142
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 130
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 129
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 124
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 120
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 108
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 107
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 97
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 97
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 96
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 94
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 91
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 88
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 87
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 81
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 81
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 79
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 79
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 75
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 73
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 71
Molecular Mechanisms of Learning and Memory 69
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 68
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 68
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 66
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 63
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 61
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 59
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 55
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 52
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 51
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 50
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 48
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 46
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 46
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 45
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 45
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 42
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 41
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 39
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 38
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 30
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 30
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 28
null 27
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 25
null 25
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 22
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 20
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 19
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 18
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 10
A second life for MAO inhibitors: from CNS diseases to cancer 9
The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey 7
Investigating Amphoteric 3,4′-Biscoumarin-Based ortho-[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors 6
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 5
Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT7 receptor antagonists as compounds used to treat Alzheimer's disease symptoms 5
Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency 3
Investigating the multi-target potential for complex diseases of the alkaloidcontaining pyrrolo[2,1-a]isoquinoline scaffold 3
Totale 4.919
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Categoria #
all - tutte 22.593
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 22.593
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021327 0 0 0 0 0 24 133 37 35 35 38 25
2021/2022377 11 22 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/20251.130 39 27 73 56 41 83 172 112 84 43 167 233
2025/20261.445 337 142 189 287 322 168 0 0 0 0 0 0
Totale 4.919