IRIS
PURGATORIO, ROSA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 2.812
AS - Asia 1.493
EU - Europa 1.367
SA - Sud America 402
AF - Africa 82
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 6.163
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 2.735
SG - Singapore 548
IT - Italia 497
BR - Brasile 318
CN - Cina 305
SE - Svezia 183
RU - Federazione Russa 182
HK - Hong Kong 168
VN - Vietnam 133
DE - Germania 132
FR - Francia 88
GB - Regno Unito 76
IN - India 69
BD - Bangladesh 52
FI - Finlandia 45
CA - Canada 36
ID - Indonesia 34
AR - Argentina 30
JP - Giappone 27
BE - Belgio 26
ES - Italia 23
CI - Costa d'Avorio 22
NL - Olanda 22
PL - Polonia 22
TR - Turchia 22
MX - Messico 18
ZA - Sudafrica 18
UA - Ucraina 16
VE - Venezuela 16
AT - Austria 15
IQ - Iraq 15
IR - Iran 15
EC - Ecuador 14
MA - Marocco 11
PH - Filippine 11
KR - Corea 10
CO - Colombia 8
EG - Egitto 8
PE - Perù 8
PK - Pakistan 8
SA - Arabia Saudita 8
CZ - Repubblica Ceca 7
MY - Malesia 7
TW - Taiwan 7
AE - Emirati Arabi Uniti 6
CL - Cile 6
DZ - Algeria 6
IE - Irlanda 6
TH - Thailandia 6
AU - Australia 5
ET - Etiopia 5
IL - Israele 5
LT - Lituania 5
TN - Tunisia 5
UZ - Uzbekistan 5
CR - Costa Rica 4
JO - Giordania 4
KE - Kenya 4
NP - Nepal 4
TT - Trinidad e Tobago 4
AZ - Azerbaigian 3
CH - Svizzera 3
DK - Danimarca 3
EE - Estonia 3
JM - Giamaica 3
KG - Kirghizistan 3
KZ - Kazakistan 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
BG - Bulgaria 2
BH - Bahrain 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
KW - Kuwait 2
NI - Nicaragua 2
OM - Oman 2
RO - Romania 2
RS - Serbia 2
SY - Repubblica araba siriana 2
AF - Afghanistan, Repubblica islamica di 1
AI - Anguilla 1
BB - Barbados 1
BO - Bolivia 1
BW - Botswana 1
DO - Repubblica Dominicana 1
EU - Europa 1
GD - Grenada 1
GE - Georgia 1
GT - Guatemala 1
HN - Honduras 1
KH - Cambogia 1
LB - Libano 1
LK - Sri Lanka 1
LV - Lettonia 1
MK - Macedonia 1
MW - Malawi 1
NG - Nigeria 1
PR - Porto Rico 1
PY - Paraguay 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 6.163
Salva come PNG Salva come JPEG
Città #
Ashburn 347
Singapore 286
Chandler 234
San Jose 202
Fairfield 165
Milan 162
Hong Kong 157
Nyköping 141
Ann Arbor 103
Houston 93
Beijing 91
Bari 77
Woodbridge 74
Seattle 71
Cambridge 69
Dallas 68
Council Bluffs 66
New York 61
Wilmington 61
Boardman 54
Lauterbourg 41
Rome 41
Ho Chi Minh City 40
Roxbury 39
Helsinki 37
Los Angeles 36
Falkenstein 33
Lawrence 31
Santa Clara 31
Brooklyn 29
Hanoi 29
North Bergen 28
São Paulo 28
Munich 27
Brussels 26
Jacksonville 26
Columbus 25
Dearborn 25
Jakarta 24
Des Moines 23
Moscow 23
Abidjan 22
Tokyo 21
Nuremberg 17
San Diego 17
Montreal 16
Inglewood 14
Warsaw 14
Figino 13
Frankfurt am Main 13
Nanjing 13
Buffalo 12
Paris 12
Chicago 11
Atlanta 10
Boston 10
Johannesburg 10
Orem 10
Poplar 10
Stockholm 10
West Jordan 10
Amsterdam 9
San Francisco 9
The Dalles 9
Vienna 9
Chennai 8
Denver 8
London 8
Phoenix 8
Sannicandro di Bari 8
Tehran 8
Belo Horizonte 7
Delhi 7
Dong Ket 7
Marseille 7
Nanchang 7
New Delhi 7
Porto Alegre 7
Rio de Janeiro 7
Santa Marinella 7
Shanghai 7
Baghdad 6
Bologna 6
Buenos Aires 6
Da Nang 6
Dublin 6
Florence 6
Genoa 6
Guangzhou 6
Haiphong 6
Kansas City 6
Leawood 6
Mexico City 6
Princeton 6
Quito 6
Salt Lake City 6
Turin 6
Boydton 5
Brasília 5
Campinas 5
Totale 3.754
Salva come PNG Salva come JPEG
Nome #
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 234
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 229
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 216
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 201
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 193
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 190
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 189
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 183
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 179
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 161
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 161
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 153
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 151
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 150
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 127
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 125
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 122
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 121
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 114
Advances in synthesis of novel annulated azecines and their unique pharmacological properties 114
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 113
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 112
A Critical Appraisal of the Protective Activity of Polyphenolic Antioxidants against Iatrogenic Effects of Anticancer Chemotherapeutics 111
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 109
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 105
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 103
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 102
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 102
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 102
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 99
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 94
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 94
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 94
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 88
Molecular Mechanisms of Learning and Memory 85
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 84
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 82
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 82
Pleiotropic Effects of Direct Oral Anticoagulants in Chronic Heart Failure and Atrial Fibrillation: Machine Learning Analysis 79
Coumarin Derivative Hybrids: Novel Dual Inhibitors Targeting Acetylcholinesterase and Monoamine Oxidases for Alzheimer’s Therapy 74
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 73
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 73
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 73
HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 70
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 69
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 68
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 63
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 55
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 52
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 51
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 51
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 49
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 49
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 42
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 40
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 35
A second life for MAO inhibitors: from CNS diseases to cancer 34
Citotoxic effects against drug-resistant tumor cells of novel 12h-chromeno[2,3-c]isoquinolin-5-amine derivatives targeting g-quadruplex dna and monoamine oxidases 30
Revisiting COX-2 inhibitors for Alzheimer's disease as multitargeted ligands: Development of 4-hydrazono-pyrazolidinediones with tuned COX selectivity profile and improved cellular potency 27
null 27
Light-mediated activation/deactivation control and in vitro ADME-Tox profiling of a donepezil-like Dual AChE/MAO-B Inhibitor 26
null 25
The first-in-class 1,3,5-triazine-derived dual 5-HT6R/FAAH modulators in search for potential drug against neurodegenerative diseases with cognitive impairment 24
Investigating the multi-target potential for complex diseases of the alkaloidcontaining pyrrolo[2,1-a]isoquinoline scaffold 19
The potential of MAO inhibitors as chemotherapeutics in cancer: A literature survey 19
Investigating Amphoteric 3,4′-Biscoumarin-Based ortho-[(Dialkylamino)methyl]phenols as Dual MAO and ChE Inhibitors 16
Discovery of new dual butyrylcholinesterase (BuChE) inhibitors and 5-HT7 receptor antagonists as compounds used to treat Alzheimer's disease symptoms 15
Tunable Preparation of α‐Aminoacyl Fluorides and α‐Fluoroamides via Base‐Induced Cascade Multiple‐Cleavage Processes from Bromodifluorohydrin Reagents and Amines 13
Exploring pyrazolidinone and pyrazolidinedione scaffolds for Alzheimer's therapy: multitarget COX-2 inhibitors with anti-amyloid β, anti-tau, antioxidant, and neuroprotective activities 9
Totale 6.424
Salva come PNG Salva come JPEG
Categoria #
all - tutte 26.468
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 26.468
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022377 11 22 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024356 16 47 24 52 22 51 20 14 20 19 17 54
2024/20251.130 39 27 73 56 41 83 172 112 84 43 167 233
2025/20262.855 337 142 189 286 308 195 291 117 321 245 117 307
2026/202795 95 0 0 0 0 0 0 0 0 0 0 0
Totale 6.424