IRIS
PURGATORIO, ROSA
 Distribuzione geografica
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Continente #
NA - Nord America 1.511
EU - Europa 514
AS - Asia 201
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
SA - Sud America 1
Totale 2.234
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Nazione #
US - Stati Uniti d'America 1.509
SE - Svezia 172
IT - Italia 147
CN - Cina 118
DE - Germania 45
GB - Regno Unito 30
IN - India 27
BE - Belgio 24
SG - Singapore 23
FR - Francia 21
FI - Finlandia 20
ES - Italia 13
IR - Iran 13
UA - Ucraina 12
NL - Olanda 7
VN - Vietnam 7
RU - Federazione Russa 6
IE - Irlanda 5
CZ - Repubblica Ceca 4
JP - Giappone 4
MA - Marocco 3
TR - Turchia 3
CA - Canada 2
CH - Svizzera 2
DK - Danimarca 2
EG - Egitto 2
PL - Polonia 2
TW - Taiwan 2
AT - Austria 1
AU - Australia 1
BG - Bulgaria 1
EU - Europa 1
HK - Hong Kong 1
IL - Israele 1
KR - Corea 1
NP - Nepal 1
PE - Perù 1
Totale 2.234
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Città #
Chandler 234
Fairfield 165
Nyköping 141
Ashburn 122
Ann Arbor 103
Houston 86
Woodbridge 74
Cambridge 69
Seattle 66
Bari 65
Wilmington 58
Roxbury 39
Lawrence 31
Jacksonville 26
New York 26
Dearborn 25
Brussels 24
Brooklyn 23
Des Moines 23
Boardman 22
San Diego 17
Milan 15
Beijing 14
Inglewood 14
Helsinki 13
Nanjing 13
Munich 11
Singapore 11
West Jordan 10
Paris 8
Dong Ket 7
Marseille 7
Nanchang 7
Santa Marinella 7
Leawood 6
Princeton 6
Tehran 6
Dublin 5
Guangzhou 5
Moscow 5
Brno 4
Delhi 4
Guwahati 4
Jiaxing 4
Kansas City 4
Rome 4
Shanghai 4
Shenyang 4
St Albans 4
Washington 4
Wuxi 4
Almere Stad 3
Azrou 3
Boydton 3
Hebei 3
Jinhua 3
Kolkata 3
Los Angeles 3
New Delhi 3
Norwalk 3
Visakhapatnam 3
Wuhan 3
Arezzo 2
Arzano 2
Bhubaneswar 2
Changsha 2
Copenhagen 2
Hefei 2
Hounslow 2
Ismailia 2
London 2
Lucknow 2
Lugano 2
Madrid 2
Mola di Bari 2
Ningbo 2
Nürnberg 2
Osaka 2
Pescara 2
San Francisco 2
San Mateo 2
Sannicandro di Bari 2
Warsaw 2
Zhengzhou 2
Acton 1
Ardabil 1
Arequipa 1
Augusta 1
Bhiwandi 1
Borås 1
Brisbane 1
Cerro Maggiore 1
Chengdu 1
Chiswick 1
Cologno Monzese 1
Dalian 1
Dhule 1
Esslingen am Neckar 1
Fuzhou 1
Gangnam-gu 1
Totale 1.746
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Nome #
Design, synthesis and biological evaluation of indane 2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as b-amyloid aggregation inhibitors 140
A new class of 1-aryl-5,6-dihydropyrrolo[2,1-a]isoquinoline derivatives as reversers of P-glycoprotein-mediated multidrug resistance in tumor cells 130
Insights into Structure-Activity Relationships of 3-Arylhydrazonoindolin-2-One Derivatives for Their Multitarget Activity on β-Amyloid Aggregation and Neurotoxicity 119
A Prospective Repurposing of Dantrolene as a Multitarget Agent for Alzheimer’s Disease 117
Novel bisphosphonates with antiresorptive effect in bone mineralization and osteoclastogenesis 116
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease 103
Investigation on the influence of (Z)-3-(2-(3-chlorophenyl)hydrazono)-5,6-dihydroxyindolin-2-one (PT2) on β-amyloid(1-40) aggregation and toxicity 95
Microfluidic pervaporation of ethanol from radiopharmaceutical formulations 91
Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction 74
Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach 72
Annelated medium-sized azaheterocycles as attractive scaffolds for CNS targeted leads. 68
Pyrrolo[2,1-a]isoquinoline scaffold in drug discovery: Advances in synthesis and medicinal chemistry 67
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 66
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 65
Isatin 3-arylhydrazones: from inhibitors of amyloidogenesis to multitarget agents with potential in Alzheimer’s disease. 64
Repositioning of dantrolene for Alzheimer’s disease: new and old biological activities towards AD-related targets. 63
Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as beta-amyloid aggregation inhibitors 62
Molecular optimization of O-glycoside inhibitors of blood coagulation factors. 60
Evaluation of water‐soluble Mannich base prodrugs of 2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as multitarget‐directed agents for Alzheimer’s disease 57
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimer’s disease. 54
3D-QSAR and pharmacophore mapping of 1H-indole-2,3-dione adducts inhibiting beta-amyloid aggregation and other major targets related to Alzheimer’s Disease. 48
First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease 48
Reductive Domino Reaction to Access Chromeno [2, 3-c] isoquinoline-5-amines with Antiproliferative Activities Against Human Tumor Cells 47
1,3,5-triazine derivatives as dual inhibitors of 5-HT6R/FAAH in search of new therapy for Alzheimer's disease 46
Biophysical characterization of inhibition of Aβ fibril formation by isatin-3-arylhydrazones 46
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as β-amyloid aggregation inhibitors 45
Molecular Mechanisms of Learning and Memory 40
Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets 39
Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential 31
null 27
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HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF 25
Synthesis of 8-phenyl substituted 3-benzazecines with allene moiety, their thermal rearrangement and evaluation as acetylcholinesterase inhibitors 25
Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection 24
Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease 24
HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF 24
Identification of chromeno[3,2-c]pyridine as suitable scaffold of novel multitarget-directed ligands for the treatment of Alzheimers disease 22
Enantiomeric Separation and Molecular Modelling of Bioactive 4-Aryl-3,4-dihydropyrimidin-2(1H)-one Ester Derivatives on Teicoplanin-Based Chiral Stationary Phase 21
Synthesis and biological evaluation of Mannich base derivatives of the neuroprotective 6-(2-phenylethyl)-3,4,5,6-tetrahydroazepino[4,3- b]indol-1(2H)-one 19
Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases 17
Biophysical Characterization of Inhibition of A-beta Fibril Formation by Isatin-3-arylhydrazones 12
The pivotal role of pyrrolidine ring as multitarget scaffold in neurodegenerative diseases 9
Synthesis and biological evaluation of arylhydrazone derivatives of indoles and indolin-2-ones as b-amyloid aggregation inhibitors 9
Multitarget 5-HT6R/FAAH/ChE ligands: the future of Alzheimer’s Disease treatment? 7
Chemical and Biological Evaluation of Novel 1H-Chromeno[3,2-c]pyridine Derivatives as MAO Inhibitors Endowed with Potential Anticancer Activity 7
A second life for MAO inhibitors? From CNS diseases to anticancer therapy 6
Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity 5
Synthesis of Novel Benzo[b][1,6]naphthyridine Derivatives and Investigation of Their Potential as Scaffolds of MAO Inhibitors 5
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 4
Radiosynthesis and whole-body distribution in mice of a 18 F-labeled azepino[4,3-b]indole-1-one derivative with multimodal activity for the treatment of Alzheimer's disease 3
Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino[4,3-b]indol-1(2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults 3
Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity 2
A Critical Appraisal of the Protecting Activity of Polyphenolic Antioxidants Against Iatrogenic Effects of Anticancer Chemotherapeutics§ 2
Novel thienocycloalkylpyridazinones as useful scaffolds for acetylcholinesterase inhibition and serotonin 5-HT6 receptor interaction 2
In-vitro and in-silico studies of annelated 1,4,7,8-tetrahydroazocine ester derivatives as nanomolar selective inhibitors of human butyrylcholinesterase 1
Nature-Inspired 1-Phenylpyrrolo[2,1-a]isoquinoline Scaffold for Novel Antiproliferative Agents Circumventing P-Glycoprotein-Dependent Multidrug Resistance 1
Totale 2.404
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Categoria #
all - tutte 11.962
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 11.962
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020345 0 22 6 47 29 40 54 37 41 32 26 11
2020/2021439 26 17 20 19 30 24 133 37 35 35 38 25
2021/2022377 11 22 35 6 15 22 16 15 34 41 61 99
2022/2023662 80 94 41 50 78 47 13 85 97 26 34 17
2023/2024359 16 47 24 52 22 51 21 14 20 19 18 55
2024/202557 40 17 0 0 0 0 0 0 0 0 0 0
Totale 2.404