IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 8.895
AS - Asia 4.237
EU - Europa 3.139
SA - Sud America 1.119
AF - Africa 176
OC - Oceania 17
Continente sconosciuto - Info sul continente non disponibili 7
Totale 17.590
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Nazione #
US - Stati Uniti d'America 8.751
SG - Singapore 1.711
CN - Cina 1.019
BR - Brasile 896
IT - Italia 640
HK - Hong Kong 505
SE - Svezia 421
FR - Francia 349
RU - Federazione Russa 343
DE - Germania 342
UA - Ucraina 320
VN - Vietnam 260
FI - Finlandia 247
GB - Regno Unito 201
IN - India 183
BD - Bangladesh 92
AR - Argentina 72
CA - Canada 66
TR - Turchia 60
IQ - Iraq 52
CI - Costa d'Avorio 50
JP - Giappone 50
ID - Indonesia 46
MX - Messico 45
BE - Belgio 38
IE - Irlanda 37
NL - Olanda 35
VE - Venezuela 34
ZA - Sudafrica 33
EC - Ecuador 31
IR - Iran 31
SA - Arabia Saudita 31
CO - Colombia 30
ES - Italia 30
PL - Polonia 29
PH - Filippine 26
PK - Pakistan 26
JO - Giordania 21
AT - Austria 19
UZ - Uzbekistan 19
CL - Cile 17
TN - Tunisia 17
KE - Kenya 16
AU - Australia 14
KR - Corea 14
EG - Egitto 13
PE - Perù 13
CH - Svizzera 12
CZ - Repubblica Ceca 12
MA - Marocco 12
MY - Malesia 12
LT - Lituania 10
PY - Paraguay 10
DZ - Algeria 9
JM - Giamaica 9
BO - Bolivia 8
NP - Nepal 8
RO - Romania 8
KG - Kirghizistan 7
LB - Libano 7
KZ - Kazakistan 6
OM - Oman 6
SN - Senegal 6
TT - Trinidad e Tobago 6
UY - Uruguay 6
BG - Bulgaria 5
GE - Georgia 5
PT - Portogallo 5
AZ - Azerbaigian 4
BH - Bahrain 4
ET - Etiopia 4
GR - Grecia 4
MD - Moldavia 4
RS - Serbia 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
AO - Angola 3
BA - Bosnia-Erzegovina 3
EU - Europa 3
GT - Guatemala 3
IL - Israele 3
KW - Kuwait 3
NO - Norvegia 3
PS - Palestinian Territory 3
SI - Slovenia 3
SK - Slovacchia (Repubblica Slovacca) 3
TW - Taiwan 3
A1 - Anonimo 2
AL - Albania 2
BN - Brunei Darussalam 2
CD - Congo 2
CR - Costa Rica 2
CY - Cipro 2
DO - Repubblica Dominicana 2
GA - Gabon 2
HN - Honduras 2
LV - Lettonia 2
MM - Myanmar 2
NI - Nicaragua 2
NZ - Nuova Zelanda 2
Totale 17.553
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Città #
Singapore 870
Ashburn 851
Jacksonville 718
Chandler 692
Fairfield 635
Woodbridge 572
San Jose 539
Hong Kong 498
Houston 396
Cambridge 342
Nyköping 298
Ann Arbor 281
Seattle 271
Dallas 263
Wilmington 237
Beijing 235
Bari 217
Lawrence 174
Roxbury 171
Lauterbourg 163
Nanjing 156
Princeton 137
Boardman 129
New York 125
Los Angeles 118
Des Moines 108
Ho Chi Minh City 99
Inglewood 81
São Paulo 81
Council Bluffs 79
Helsinki 75
Santa Clara 60
Buffalo 55
Hanoi 55
Abidjan 50
Nanchang 49
Munich 47
Brooklyn 45
Frankfurt am Main 44
Hebei 41
Chicago 40
Brussels 38
Tokyo 38
Dublin 37
Jiaxing 37
Dearborn 32
San Diego 32
Tianjin 32
Changsha 31
Rio de Janeiro 31
Rome 31
Orem 30
Shenyang 29
Toronto 29
London 28
Marseille 28
Mumbai 27
Chennai 26
Belo Horizonte 25
Paris 25
Washington 25
Guangzhou 24
Moscow 24
Istanbul 23
San Francisco 23
Baghdad 22
Jakarta 21
Stockholm 21
Leawood 20
Warsaw 20
Amman 19
Tashkent 19
Wuhan 19
Augusta 18
Falkenstein 18
Milan 18
Nuremberg 17
Denver 16
Atlanta 15
Brasília 15
Caracas 15
Johannesburg 15
Manchester 15
Amsterdam 14
Curitiba 14
Dhaka 14
Sannicandro di Bari 14
Campinas 13
Montreal 13
Nairobi 13
Pune 13
Shanghai 13
Tunis 13
Guayaquil 12
Jeddah 12
Jinan 12
Mexico City 12
Quito 12
Turku 12
Boston 11
Totale 11.342
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Nome #
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 234
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 214
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 207
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 204
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 189
Activation and inhibition of kidney CLC-K chloride channels by fenamates 184
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 180
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 174
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 167
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 167
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 159
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 155
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 153
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 151
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 149
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 147
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 144
Chemical composition and antibacterial activity of seven uncommon essential oils 143
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 141
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 136
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 134
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 133
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 133
Antimicrobial Activity of Essential Oils Evaluated In Vitro against Escherichia coli and Staphylococcus aureus 132
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 130
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 128
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 127
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 126
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 125
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 123
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 122
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 122
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 120
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 120
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 119
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 118
Slightly viscous dispersions of mucoadhesive polymers as vehicles for nasal administration of dopamine and grape seed extract-loaded solid lipid nanoparticles 117
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 115
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 115
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 114
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 114
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 114
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 114
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 114
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 114
Dopamine and Antioxidant Grape Seed Extract loaded chitosan nanoparticles: A preliminary in vitro characterization 113
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 111
Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus 111
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 110
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 109
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 108
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 107
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 106
Analisi conduttimetrica 106
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 106
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 104
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 104
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 102
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 102
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 101
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 101
Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells 101
Carboxymethyl chitosan dopamine conjugates: Synthesis and evaluation for intranasal anti Parkinson therapy 97
Dopamine - and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson’s Disease 97
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 96
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 95
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 95
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 95
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 94
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 94
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 93
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 93
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 92
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 92
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 91
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 91
Antibiofilm Effects of Plant Extracts Against Staphylococcus aureus 89
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 89
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 89
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 88
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 88
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 87
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 87
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 86
Combining Inorganic Antibacterial Nanophases and Essential Oils: Recent Findings and Prospects 86
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 86
Antioxidant based Solid Lipid Nanoparticles: in vitro studies on the administration of citicoline for supporting anti-Parkinson therapy 85
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 85
Lipases for biocatalysis: development of a chromatographic bioreactor 85
Antifungal Biofilm Inhibitory Effects of Combinations of Diclofenac and Essential Oils 84
Exploring the Antibiofilm Effect of Sertraline in Synergy with Cinnamomum verum Essential Oil to Counteract Candida Species 83
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 83
Virucidal Activity of Lemon Essential Oil against Feline Calicivirus Used as Surrogate for Norovirus 82
New clofibric acid analogues with potential activity on PPARs 81
Solid Lipid Nanoparticles Containing Dopamine and Grape Seed Extract: Freeze-Drying with Cryoprotection as a Formulation Strategy to Achieve Nasal Powders 80
Solid Lipid Nanoparticles Administering Antioxidant Grape Seed-Derived Polyphenol Compounds: A Potential Application in Aquaculture 80
Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis 79
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 79
Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity 79
Synthesis and biological evaluation of sulfonyl phosphonic acids as new MMPs inhibitors. 78
Totale 11.576
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Categoria #
all - tutte 72.875
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 72.875
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021459 0 0 0 0 0 0 0 0 0 202 160 97
2021/20221.208 44 183 10 34 49 48 54 51 54 55 223 403
2022/20231.992 347 126 107 178 286 262 20 197 376 12 42 39
2023/2024968 67 141 62 59 94 201 40 64 40 53 37 110
2024/20252.940 111 61 255 164 74 218 186 280 151 146 398 896
2025/20265.608 860 375 493 736 613 376 801 226 604 524 0 0
Totale 17.979