IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 9.902
AS - Asia 4.320
EU - Europa 3.969
SA - Sud America 1.155
Continente sconosciuto - Info sul continente non disponibili 408
AF - Africa 179
OC - Oceania 17
Totale 19.950
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Nazione #
US - Stati Uniti d'America 9.713
SG - Singapore 1.731
IT - Italia 1.454
CN - Cina 1.034
BR - Brasile 906
HK - Hong Kong 512
SE - Svezia 421
FR - Francia 352
RU - Federazione Russa 343
DE - Germania 342
UA - Ucraina 321
VN - Vietnam 260
FI - Finlandia 247
GB - Regno Unito 207
IN - India 189
BD - Bangladesh 107
CA - Canada 93
AR - Argentina 74
TR - Turchia 62
IQ - Iraq 52
JP - Giappone 52
CI - Costa d'Avorio 50
ID - Indonesia 49
MX - Messico 48
CO - Colombia 42
BE - Belgio 38
EC - Ecuador 38
IE - Irlanda 38
NL - Olanda 36
VE - Venezuela 35
SA - Arabia Saudita 34
ZA - Sudafrica 33
IR - Iran 31
ES - Italia 30
PH - Filippine 30
PL - Polonia 29
PK - Pakistan 26
JO - Giordania 21
AT - Austria 19
CL - Cile 19
UZ - Uzbekistan 19
TN - Tunisia 17
KE - Kenya 16
KR - Corea 16
AU - Australia 14
MY - Malesia 14
CH - Svizzera 13
EG - Egitto 13
PE - Perù 13
CZ - Repubblica Ceca 12
JM - Giamaica 12
MA - Marocco 12
LT - Lituania 10
PY - Paraguay 10
BO - Bolivia 9
DZ - Algeria 9
NP - Nepal 9
RO - Romania 8
KG - Kirghizistan 7
LB - Libano 7
TT - Trinidad e Tobago 7
KZ - Kazakistan 6
OM - Oman 6
SN - Senegal 6
UY - Uruguay 6
BG - Bulgaria 5
CR - Costa Rica 5
GE - Georgia 5
MD - Moldavia 5
PT - Portogallo 5
RS - Serbia 5
AZ - Azerbaigian 4
BH - Bahrain 4
ET - Etiopia 4
GR - Grecia 4
NI - Nicaragua 4
AE - Emirati Arabi Uniti 3
AM - Armenia 3
AO - Angola 3
BA - Bosnia-Erzegovina 3
EU - Europa 3
GT - Guatemala 3
HN - Honduras 3
IL - Israele 3
KW - Kuwait 3
NO - Norvegia 3
PS - Palestinian Territory 3
SI - Slovenia 3
SK - Slovacchia (Repubblica Slovacca) 3
SV - El Salvador 3
TH - Thailandia 3
TW - Taiwan 3
XK - ???statistics.table.value.countryCode.XK??? 3
A1 - Anonimo 2
AL - Albania 2
BN - Brunei Darussalam 2
CD - Congo 2
CG - Congo 2
CY - Cipro 2
DO - Repubblica Dominicana 2
Totale 19.504
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Città #
Ashburn 900
Singapore 883
San Jose 730
Jacksonville 721
Chandler 692
Fairfield 635
Woodbridge 572
Hong Kong 505
Milan 469
Houston 396
Cambridge 343
Nyköping 298
Council Bluffs 288
Dallas 282
Ann Arbor 281
Seattle 271
Beijing 242
Wilmington 237
Bari 231
Lawrence 174
Roxbury 171
Rome 165
Lauterbourg 163
Nanjing 156
New York 142
Boardman 141
Princeton 137
Los Angeles 129
Des Moines 108
Ho Chi Minh City 99
Santa Clara 88
Inglewood 81
São Paulo 81
Helsinki 75
Buffalo 59
Hanoi 55
Chicago 52
Abidjan 50
Figino 50
Brooklyn 49
Nanchang 49
Munich 47
Frankfurt am Main 44
Hebei 41
Tokyo 40
Brussels 38
Dublin 37
Jiaxing 37
Toronto 37
Dearborn 33
San Diego 33
Tianjin 32
Changsha 31
Rio de Janeiro 31
Orem 30
Columbus 29
London 29
Shenyang 29
Washington 29
Marseille 28
Mumbai 27
Turin 27
Chennai 26
Paris 26
Belo Horizonte 25
San Francisco 25
Guangzhou 24
Moscow 24
Istanbul 23
Baghdad 22
Jakarta 21
Naples 21
Stockholm 21
Atlanta 20
Leawood 20
Phoenix 20
Warsaw 20
Amman 19
Montreal 19
Tashkent 19
Wuhan 19
Augusta 18
Denver 18
Falkenstein 18
Nuremberg 17
Manchester 16
Taranto 16
Brasília 15
Caracas 15
Johannesburg 15
Quito 15
Amsterdam 14
Bologna 14
Campinas 14
Curitiba 14
Dhaka 14
Guayaquil 14
Mexico City 14
Sannicandro di Bari 14
Nairobi 13
Totale 12.661
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Nome #
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 256
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 230
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 220
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 211
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 199
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 194
Activation and inhibition of kidney CLC-K chloride channels by fenamates 190
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 184
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 180
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 175
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 166
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 164
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 163
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 161
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 159
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 159
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 155
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 153
Slightly viscous dispersions of mucoadhesive polymers as vehicles for nasal administration of dopamine and grape seed extract-loaded solid lipid nanoparticles 151
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 149
Chemical composition and antibacterial activity of seven uncommon essential oils 149
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 148
Antimicrobial Activity of Essential Oils Evaluated In Vitro against Escherichia coli and Staphylococcus aureus 147
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 141
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 139
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 138
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 138
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 136
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 135
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 135
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 134
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 134
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 133
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 132
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 131
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 128
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 128
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 127
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 125
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 125
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 125
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 124
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 123
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 122
Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus 122
Dopamine and Antioxidant Grape Seed Extract loaded chitosan nanoparticles: A preliminary in vitro characterization 121
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 121
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 120
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 120
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 120
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 118
Non-Antibiotic Drug Repositioning as an Alternative Antimicrobial Approach 117
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 115
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 115
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 115
Analisi conduttimetrica 114
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 113
Dopamine - and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson’s Disease 109
Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells 109
Antioxidant based Solid Lipid Nanoparticles: in vitro studies on the administration of citicoline for supporting anti-Parkinson therapy 108
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 108
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 108
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 108
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 108
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 107
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 107
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 106
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 106
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 106
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 105
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 105
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 105
Carboxymethyl chitosan dopamine conjugates: Synthesis and evaluation for intranasal anti Parkinson therapy 103
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 103
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 103
Antifungal Biofilm Inhibitory Effects of Combinations of Diclofenac and Essential Oils 103
Exploring the Antibiofilm Effect of Sertraline in Synergy with Cinnamomum verum Essential Oil to Counteract Candida Species 102
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 102
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 102
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 101
Solid Lipid Nanoparticles Containing Dopamine and Grape Seed Extract: Freeze-Drying with Cryoprotection as a Formulation Strategy to Achieve Nasal Powders 100
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 100
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 98
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 97
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 96
Combining Inorganic Antibacterial Nanophases and Essential Oils: Recent Findings and Prospects 96
Antibiofilm Effects of Plant Extracts Against Staphylococcus aureus 95
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 95
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 94
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 93
Characterization of two synthetic ligands of peroxisome proliferator-activated receptor (PPAR) by cofactor recruitment, site-directed mutagenesis and structure analysis 92
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 92
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 92
Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity 92
Virucidal Activity of Lemon Essential Oil against Feline Calicivirus Used as Surrogate for Norovirus 89
Lipases for biocatalysis: development of a chromatographic bioreactor 89
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 88
Solid Lipid Nanoparticles for delivery of Dopamine and Grape Seed Extracts in differentiated SH-SY5Y neuronal cell model of Parkinson disease. 87
New clofibric acid analogues with potential activity on PPARs 87
Synthesis and biological evaluation of sulfonyl phosphonic acids as new MMPs inhibitors. 87
Totale 12.630
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Categoria #
all - tutte 82.031
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 82.031
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022981 0 0 10 34 49 48 54 51 54 55 223 403
2022/20231.992 347 126 107 178 286 262 20 197 376 12 42 39
2023/2024968 67 141 62 59 94 201 40 64 40 53 37 110
2024/20252.940 111 61 255 164 74 218 186 280 151 146 398 896
2025/20266.674 860 375 493 736 613 376 801 226 604 585 178 827
2026/2027905 170 365 370 0 0 0 0 0 0 0 0 0
Totale 19.950