IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 7.956
AS - Asia 3.468
EU - Europa 2.690
SA - Sud America 921
AF - Africa 113
OC - Oceania 16
Continente sconosciuto - Info sul continente non disponibili 7
Totale 15.171
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Nazione #
US - Stati Uniti d'America 7.841
SG - Singapore 1.468
CN - Cina 919
BR - Brasile 802
IT - Italia 518
HK - Hong Kong 488
SE - Svezia 418
RU - Federazione Russa 330
UA - Ucraina 317
DE - Germania 314
FI - Finlandia 201
VN - Vietnam 200
FR - Francia 181
GB - Regno Unito 179
IN - India 105
CA - Canada 61
CI - Costa d'Avorio 49
AR - Argentina 43
JP - Giappone 39
BE - Belgio 38
ID - Indonesia 38
BD - Bangladesh 35
IE - Irlanda 34
IR - Iran 31
MX - Messico 31
TR - Turchia 30
NL - Olanda 26
EC - Ecuador 21
PL - Polonia 21
ES - Italia 20
IQ - Iraq 20
ZA - Sudafrica 20
AT - Austria 18
VE - Venezuela 15
CO - Colombia 14
KR - Corea 14
AU - Australia 13
CH - Svizzera 12
CZ - Repubblica Ceca 12
UZ - Uzbekistan 12
JO - Giordania 11
SA - Arabia Saudita 11
CL - Cile 9
KE - Kenya 8
LT - Lituania 8
MA - Marocco 8
PE - Perù 8
EG - Egitto 7
PK - Pakistan 7
DZ - Algeria 6
PY - Paraguay 6
TT - Trinidad e Tobago 6
JM - Giamaica 5
KZ - Kazakistan 5
NP - Nepal 5
PT - Portogallo 5
RO - Romania 5
BG - Bulgaria 4
MD - Moldavia 4
TN - Tunisia 4
AZ - Azerbaigian 3
BA - Bosnia-Erzegovina 3
EU - Europa 3
GE - Georgia 3
GT - Guatemala 3
NO - Norvegia 3
OM - Oman 3
PH - Filippine 3
RS - Serbia 3
SI - Slovenia 3
SK - Slovacchia (Repubblica Slovacca) 3
TW - Taiwan 3
A1 - Anonimo 2
AL - Albania 2
AM - Armenia 2
GA - Gabon 2
GR - Grecia 2
IL - Israele 2
LB - Libano 2
NZ - Nuova Zelanda 2
SN - Senegal 2
XK - ???statistics.table.value.countryCode.XK??? 2
AD - Andorra 1
AO - Angola 1
BB - Barbados 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BO - Bolivia 1
CD - Congo 1
CG - Congo 1
CR - Costa Rica 1
CY - Cipro 1
DK - Danimarca 1
DM - Dominica 1
DO - Repubblica Dominicana 1
EE - Estonia 1
GD - Grenada 1
GY - Guiana 1
HN - Honduras 1
HR - Croazia 1
Totale 15.154
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Città #
Ashburn 733
Jacksonville 718
Chandler 692
Singapore 681
Fairfield 635
Woodbridge 572
Hong Kong 484
Houston 394
Cambridge 342
Nyköping 298
Ann Arbor 281
Seattle 271
Dallas 260
Wilmington 237
Beijing 232
Bari 185
Lawrence 174
Roxbury 171
Nanjing 156
Princeton 137
Boardman 129
New York 118
Des Moines 108
Los Angeles 106
Ho Chi Minh City 86
Inglewood 81
São Paulo 72
Buffalo 51
Abidjan 49
Nanchang 49
Munich 47
Brooklyn 43
Hanoi 42
Santa Clara 42
Hebei 41
Brussels 38
Chicago 38
Jiaxing 37
Dublin 34
Council Bluffs 33
Frankfurt am Main 33
Dearborn 32
San Diego 32
Tianjin 32
Changsha 31
Helsinki 29
Shenyang 29
Rio de Janeiro 28
Marseille 27
Tokyo 27
Toronto 27
London 26
Washington 25
Belo Horizonte 23
Guangzhou 23
Moscow 23
Paris 21
Leawood 20
San Francisco 20
Jakarta 19
Mumbai 19
Augusta 18
Stockholm 18
Wuhan 18
Rome 17
Chennai 16
Milan 16
Brasília 14
Nuremberg 14
Sannicandro di Bari 14
Campinas 13
Warsaw 13
Curitiba 12
Jinan 12
Montreal 12
Pune 12
Shanghai 12
Tashkent 12
Turku 12
Amman 11
Istanbul 11
Johannesburg 11
Amsterdam 10
Genova 10
Manchester 10
North Bergen 10
Quito 10
San Mateo 10
Taranto 10
Vienna 10
Atlanta 9
Baghdad 9
Haikou 9
Ardabil 8
Biên Hòa 8
Boston 8
Denver 8
Goiânia 8
Kunming 8
Long Beach 8
Totale 9.894
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Nome #
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 191
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 189
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 188
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 182
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 173
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 171
Activation and inhibition of kidney CLC-K chloride channels by fenamates 165
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 157
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 155
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 144
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 143
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 143
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 143
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 138
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 137
Chemical composition and antibacterial activity of seven uncommon essential oils 131
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 129
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 127
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 127
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 124
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 121
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 121
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 120
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 118
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 114
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 113
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 112
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 112
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 110
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 109
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 108
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 107
Antimicrobial Activity of Essential Oils Evaluated In Vitro against Escherichia coli and Staphylococcus aureus 106
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 106
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 106
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 105
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 104
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 103
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 102
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 102
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 101
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 99
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 98
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 97
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 96
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 96
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 96
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 96
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 96
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 95
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 95
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 92
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 92
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 91
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 91
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 90
Dopamine and Antioxidant Grape Seed Extract loaded chitosan nanoparticles: A preliminary in vitro characterization 89
Analisi conduttimetrica 89
Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus 88
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 87
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 84
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 84
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 84
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 83
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 83
Combined Dopamine and Grape Seed Extract-Loaded Solid Lipid Nanoparticles: Nasal Mucosa Permeation, and Uptake by Olfactory Ensheathing Cells and Neuronal SH-SY5Y Cells 83
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 82
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 82
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 82
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 82
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 82
Slightly viscous dispersions of mucoadhesive polymers as vehicles for nasal administration of dopamine and grape seed extract-loaded solid lipid nanoparticles 81
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 81
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 80
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 79
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 79
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 79
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 79
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 77
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 77
Lipases for biocatalysis: development of a chromatographic bioreactor 77
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 77
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 74
Carboxymethyl chitosan dopamine conjugates: Synthesis and evaluation for intranasal anti Parkinson therapy 73
New clofibric acid analogues with potential activity on PPARs 72
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 72
Characterization of two synthetic ligands of peroxisome proliferator-activated receptor (PPAR) by cofactor recruitment, site-directed mutagenesis and structure analysis 72
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 72
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 70
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 70
Biological activity of alpha-substituted-aryloxyacetic acids and their isosteres 70
Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis 69
New 2-aryloxy-3-phenyl-propanoic acids as peroxisome proliferator-activated receptors alpha/gamma dual agonists with improved potency and reduced adverse effects on skeletal muscle function 68
Synthesis, SAR, and Biological Evaluation of alpha-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors 67
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 67
Dopamine - and Grape-Seed-Extract-Loaded Solid Lipid Nanoparticles: Interaction Studies between Particles and Differentiated SH-SY5Y Neuronal Cell Model of Parkinson’s Disease 66
Virucidal Activity of Lemon Essential Oil against Feline Calicivirus Used as Surrogate for Norovirus 64
Synthesis and biological evaluation of sulfonyl phosphonic acids as new MMPs inhibitors. 64
MOLECULAR SPATIAL GEOMETRY OF CLC-K LIGANDS: OPTIMAL REQUIREMENTS TOWARDS HIGH AFFINITY CHANNEL BLOCK. 64
Development and Application of chromatographic tools based on immobilized PPAR-gamma receptor for binding studies 64
Totale 10.145
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Categoria #
all - tutte 67.828
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 67.828
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021787 0 0 0 0 0 31 88 62 147 202 160 97
2021/20221.208 44 183 10 34 49 48 54 51 54 55 223 403
2022/20231.992 347 126 107 178 286 262 20 197 376 12 42 39
2023/2024968 67 141 62 59 94 201 40 64 40 53 37 110
2024/20252.940 111 61 255 164 74 218 186 280 151 146 398 896
2025/20263.185 860 375 493 736 613 108 0 0 0 0 0 0
Totale 15.556