IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 6.460
EU - Europa 1.842
AS - Asia 642
SA - Sud America 13
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 5
AF - Africa 1
Totale 8.972
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Nazione #
US - Stati Uniti d'America 6.437
CN - Cina 523
SE - Svezia 400
IT - Italia 389
UA - Ucraina 311
DE - Germania 213
FI - Finlandia 179
FR - Francia 145
GB - Regno Unito 112
IN - India 48
BE - Belgio 30
IE - Irlanda 30
CA - Canada 18
JP - Giappone 16
IR - Iran 15
BR - Brasile 10
CH - Svizzera 10
KR - Corea 9
TR - Turchia 9
AU - Australia 7
NL - Olanda 6
ID - Indonesia 5
VN - Vietnam 5
HK - Hong Kong 4
JM - Giamaica 4
BG - Bulgaria 3
EU - Europa 3
A1 - Anonimo 2
CL - Cile 2
LT - Lituania 2
NZ - Nuova Zelanda 2
PK - Pakistan 2
PL - Polonia 2
PT - Portogallo 2
RO - Romania 2
SG - Singapore 2
CO - Colombia 1
DK - Danimarca 1
EE - Estonia 1
EG - Egitto 1
ES - Italia 1
HR - Croazia 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LV - Lettonia 1
MX - Messico 1
PH - Filippine 1
TH - Thailandia 1
TW - Taiwan 1
Totale 8.972
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Città #
Jacksonville 715
Chandler 692
Fairfield 635
Woodbridge 572
Ashburn 418
Houston 385
Cambridge 341
Nyköping 298
Ann Arbor 271
Seattle 263
Wilmington 236
Lawrence 173
Roxbury 170
Bari 162
Nanjing 153
Princeton 137
Boardman 107
Des Moines 107
New York 91
Beijing 83
Inglewood 81
Nanchang 49
Hebei 40
Jiaxing 34
Dearborn 32
San Diego 32
Brussels 30
Dublin 30
Tianjin 30
Changsha 29
Shenyang 29
Marseille 27
Brooklyn 26
Washington 23
Los Angeles 22
Helsinki 20
Leawood 20
Paris 19
Augusta 16
Sannicandro di Bari 14
Toronto 14
Rome 13
Jinan 12
London 12
San Francisco 12
Mumbai 11
Pune 11
Genova 10
San Mateo 10
Haikou 9
Taranto 9
Ardabil 8
Kunming 8
Long Beach 8
Redwood City 8
Frankfurt am Main 7
Lausanne 7
Monmouth Junction 7
Tokyo 7
Boydton 6
Milan 6
Norwalk 6
Zhengzhou 6
Guangzhou 5
Ningbo 5
Osaka 5
Osasco 5
Auburn Hills 4
Bologna 4
Dong Ket 4
Guys Hill 4
Hefei 4
Napoli 4
Prescot 4
Brahmapur 3
Caserta 3
Chiswick 3
Cleveland 3
Dongjak-gu 3
Islington 3
Melbourne 3
Nürnberg 3
Pizzo 3
Sydney 3
Taizhou 3
Triggiano 3
Zurich 3
Aradeo 2
Barletta 2
Bengaluru 2
Brasília 2
Camden 2
Cassano Magnago 2
Chennai 2
Chicago 2
Chongqing 2
Delhi 2
Duncan 2
East Hartford 2
Edinburgh 2
Totale 6.932
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Nome #
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 134
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 126
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 126
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 125
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 116
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 115
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 114
Chemical composition and antibacterial activity of seven uncommon essential oils 107
Activation and inhibition of kidney CLC-K chloride channels by fenamates 106
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 102
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 98
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 97
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 97
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 96
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 95
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 94
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 94
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 91
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 90
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 88
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 87
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 86
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 86
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 84
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 81
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 81
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 81
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 79
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 76
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 75
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 75
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 72
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 72
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 72
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 70
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 70
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 67
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 67
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 67
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 67
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 65
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 65
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 65
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 64
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 64
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 64
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 64
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 63
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 63
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 62
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 61
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 59
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 59
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 57
Lipases for biocatalysis: development of a chromatographic bioreactor 57
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 56
null 56
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 55
New clofibric acid analogues with potential activity on PPARs 52
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 52
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 52
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 52
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 51
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 51
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 51
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 50
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 50
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 49
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 49
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 49
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 48
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 48
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 48
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 48
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 48
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Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 47
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 47
Biological activity of a-substituted-aryloxyacetic acids and their isosteres 46
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 45
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 45
null 45
Synthesis, SAR, and Biological Evaluation of alpha-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors 44
Development and Application of chromatographic tools based on immobilized PPAR-gamma receptor for binding studies 43
Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) 43
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Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 43
Characterization of two synthetic ligands of peroxisome proliferator-activated receptor (PPAR) by cofactor recruitment, site-directed mutagenesis and structure analysis 42
Sintesi di nuovi analoghi chirali dell’acido clofibrico e valutazione della loro attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alpha e gamma 42
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 42
INIBITORI SELETTIVI DI METALLOPROTEINASI DI MATRICE (MMP): SINTESI E VALUTAZIONE BIOLOGICA DI ACIDI ARIL SOLFONIL FOSFONICI. 41
Biphenylsulphonylamino Bisphosphonates as Novel Matrix Metalloproteinase Inhibitors 40
MOLECULAR SPATIAL GEOMETRY OF CLC-K LIGANDS: OPTIMAL REQUIREMENTS TOWARDS HIGH AFFINITY CHANNEL BLOCK. 40
Clofibric Acid Derivatives with PPARalpha/gamma Agonist Activity as a Novel Approach To Target Oriented Therapy in Cancer 40
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 39
ON THE MECHANISM OF PARTIAL AGONISM: CRYSTAL STRUCTURES OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORgamma LIGAND-BINDING DOMAIN IN THE COMPLEX WITH TWO ENANTIOMERIC LIGANDS 39
Synthesis and biological evaluation of alpha sulfonyl phosphonic acids as new MMPs inhibitors 39
Structural Insight into Peroxisome Proliferator-Activated Receptor γ Binding of Two Ureidofibrate-Like Enantiomers by Molecular Dynamics, Cofactor Interaction Analysis, and Site-Directed Mutagenesis 39
Analisi conduttimetrica 39
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 39
Totale 6.633
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Categoria #
all - tutte 35.309
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 35.309
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019406 0 0 0 0 0 0 0 0 0 0 186 220
2019/20202.190 450 140 44 145 222 125 265 155 265 107 222 50
2020/20211.453 233 58 123 87 166 31 88 62 146 202 160 97
2021/20221.203 44 182 10 34 48 48 54 51 54 55 222 401
2022/20231.991 346 126 107 178 286 262 20 197 376 12 42 39
2023/2024821 67 141 62 59 94 201 40 64 40 53 0 0
Totale 9.261