IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
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Continente #
NA - Nord America 6.646
EU - Europa 1.940
AS - Asia 1.092
SA - Sud America 19
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 5
AF - Africa 1
Totale 9.716
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Nazione #
US - Stati Uniti d'America 6.614
CN - Cina 671
IT - Italia 431
SE - Svezia 400
UA - Ucraina 311
SG - Singapore 278
DE - Germania 238
FI - Finlandia 183
FR - Francia 149
GB - Regno Unito 118
IN - India 54
BE - Belgio 35
IE - Irlanda 30
CA - Canada 27
IR - Iran 22
JP - Giappone 17
BR - Brasile 16
KR - Corea 12
AU - Australia 11
CH - Svizzera 11
TR - Turchia 10
NL - Olanda 6
ID - Indonesia 5
LT - Lituania 5
VN - Vietnam 5
ES - Italia 4
HK - Hong Kong 4
JM - Giamaica 4
BG - Bulgaria 3
CZ - Repubblica Ceca 3
EU - Europa 3
TW - Taiwan 3
A1 - Anonimo 2
CL - Cile 2
IQ - Iraq 2
JO - Giordania 2
NZ - Nuova Zelanda 2
PK - Pakistan 2
PL - Polonia 2
PT - Portogallo 2
RO - Romania 2
AT - Austria 1
CO - Colombia 1
DK - Danimarca 1
EE - Estonia 1
EG - Egitto 1
HR - Croazia 1
IL - Israele 1
KH - Cambogia 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LV - Lettonia 1
MX - Messico 1
PH - Filippine 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
Totale 9.716
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Città #
Jacksonville 715
Chandler 692
Fairfield 635
Woodbridge 572
Ashburn 455
Houston 385
Cambridge 341
Nyköping 298
Ann Arbor 271
Seattle 265
Wilmington 236
Singapore 208
Lawrence 173
Bari 170
Roxbury 170
Nanjing 155
Princeton 137
Boardman 128
Des Moines 107
Beijing 94
New York 91
Inglewood 81
Nanchang 49
Hebei 40
Jiaxing 37
Brussels 35
Los Angeles 34
Dearborn 32
San Diego 32
Dublin 30
Tianjin 30
Changsha 29
Shenyang 29
Marseille 27
Santa Clara 27
Brooklyn 26
Helsinki 24
Washington 23
Guangzhou 22
Leawood 20
Paris 20
Toronto 18
Wuhan 18
Augusta 16
Frankfurt am Main 14
Munich 14
Sannicandro di Bari 14
London 13
Mumbai 13
Rome 13
Jinan 12
San Francisco 12
Milan 11
Pune 11
Genova 10
San Mateo 10
Shanghai 10
Haikou 9
Taranto 9
Ardabil 8
Kunming 8
Long Beach 8
Redwood City 8
Lausanne 7
Monmouth Junction 7
Tokyo 7
Boydton 6
Norwalk 6
Osaka 6
Wuxi 6
Zhengzhou 6
Ningbo 5
Osasco 5
Sydney 5
Taizhou 5
Auburn Hills 4
Bologna 4
Delhi 4
Dong Ket 4
Dongjak-gu 4
Guys Hill 4
Hefei 4
Juazeiro do Norte 4
Naples 4
Napoli 4
Ottawa 4
Prescot 4
Salerno 4
Triggiano 4
Brahmapur 3
Caserta 3
Chiswick 3
Cleveland 3
Hangzhou 3
Islington 3
Jinhua 3
Melbourne 3
Nuremberg 3
Nürnberg 3
Pizzo 3
Totale 7.364
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Nome #
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 140
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 133
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 129
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 128
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 121
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 121
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 118
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 118
Activation and inhibition of kidney CLC-K chloride channels by fenamates 115
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 110
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 110
Chemical composition and antibacterial activity of seven uncommon essential oils 108
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 104
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 100
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 100
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 100
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 99
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 98
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 94
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 91
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 91
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 91
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 89
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 88
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 84
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 83
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 83
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 83
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 79
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 78
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 78
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 78
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 77
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 76
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 75
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 74
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 73
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 73
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 72
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 72
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 71
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 70
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 69
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 69
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 69
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 67
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 67
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 66
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 66
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 66
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 63
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 62
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 62
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 61
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 61
Lipases for biocatalysis: development of a chromatographic bioreactor 61
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 60
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 59
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 58
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 58
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 57
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 57
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 56
null 56
New clofibric acid analogues with potential activity on PPARs 55
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 55
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 55
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 55
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 55
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 54
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 54
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 53
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 52
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 52
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 52
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 51
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 49
Biological activity of a-substituted-aryloxyacetic acids and their isosteres 49
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 48
Synthesis, SAR, and Biological Evaluation of alpha-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors 48
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 48
null 48
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 48
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 47
Characterization of two synthetic ligands of peroxisome proliferator-activated receptor (PPAR) by cofactor recruitment, site-directed mutagenesis and structure analysis 46
Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) 46
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 46
Development and Application of chromatographic tools based on immobilized PPAR-gamma receptor for binding studies 45
Synthesis and biological evaluation of alpha sulfonyl phosphonic acids as new MMPs inhibitors 45
Nuovi analoghi chirali dell’acido clofibrico ad attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alfa e gamma 45
Sintesi di nuovi analoghi chirali dell’acido clofibrico e valutazione della loro attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alpha e gamma 45
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MOLECULAR SPATIAL GEOMETRY OF CLC-K LIGANDS: OPTIMAL REQUIREMENTS TOWARDS HIGH AFFINITY CHANNEL BLOCK. 44
Analisi conduttimetrica 44
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 43
Clofibric Acid Derivatives with PPARalpha/gamma Agonist Activity as a Novel Approach To Target Oriented Therapy in Cancer 43
INIBITORI SELETTIVI DI METALLOPROTEINASI DI MATRICE (MMP): SINTESI E VALUTAZIONE BIOLOGICA DI ACIDI ARIL SOLFONIL FOSFONICI. 43
null 43
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 43
Biphenylsulphonylamino Bisphosphonates as Novel Matrix Metalloproteinase Inhibitors 42
Totale 7.081
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Categoria #
all - tutte 44.140
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 44.140
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.411 0 0 0 0 222 125 265 155 265 107 222 50
2020/20211.453 233 58 123 87 166 31 88 62 146 202 160 97
2021/20221.203 44 182 10 34 48 48 54 51 54 55 222 401
2022/20231.991 346 126 107 178 286 262 20 197 376 12 42 39
2023/2024968 67 141 62 59 94 201 40 64 40 53 37 110
2024/2025654 110 61 255 164 64 0 0 0 0 0 0 0
Totale 10.062