IRIS
FRACCHIOLLA, GIUSEPPE
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 6.736
EU - Europa 2.397
AS - Asia 1.316
SA - Sud America 238
AF - Africa 15
OC - Oceania 13
Continente sconosciuto - Info sul continente non disponibili 6
Totale 10.721
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 6.692
CN - Cina 683
IT - Italia 472
SG - Singapore 414
SE - Svezia 401
RU - Federazione Russa 317
UA - Ucraina 312
DE - Germania 264
BR - Brasile 216
FI - Finlandia 189
FR - Francia 164
GB - Regno Unito 123
IN - India 55
BE - Belgio 37
CA - Canada 32
IE - Irlanda 31
HK - Hong Kong 26
IR - Iran 24
ID - Indonesia 21
TR - Turchia 20
JP - Giappone 19
NL - Olanda 16
AT - Austria 14
KR - Corea 12
AU - Australia 11
CH - Svizzera 11
CZ - Repubblica Ceca 10
BD - Bangladesh 6
LT - Lituania 6
MX - Messico 6
VN - Vietnam 6
AR - Argentina 5
IQ - Iraq 5
MA - Marocco 5
DZ - Algeria 4
ES - Italia 4
JM - Giamaica 4
PL - Polonia 4
VE - Venezuela 4
BG - Bulgaria 3
CL - Cile 3
EU - Europa 3
JO - Giordania 3
PE - Perù 3
PK - Pakistan 3
PT - Portogallo 3
RO - Romania 3
RS - Serbia 3
TW - Taiwan 3
UZ - Uzbekistan 3
A1 - Anonimo 2
CO - Colombia 2
EC - Ecuador 2
GE - Georgia 2
IL - Israele 2
KE - Kenya 2
NP - Nepal 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
ZA - Sudafrica 2
AL - Albania 1
AZ - Azerbaigian 1
DK - Danimarca 1
EE - Estonia 1
EG - Egitto 1
GR - Grecia 1
GT - Guatemala 1
GY - Guiana 1
HR - Croazia 1
KH - Cambogia 1
KZ - Kazakistan 1
LI - Liechtenstein 1
LV - Lettonia 1
MD - Moldavia 1
OM - Oman 1
PH - Filippine 1
PY - Paraguay 1
SY - Repubblica araba siriana 1
TH - Thailandia 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
UY - Uruguay 1
XK - ???statistics.table.value.countryCode.XK??? 1
Totale 10.721
Salva come PNG Salva come JPEG
Città #
Jacksonville 718
Chandler 692
Fairfield 635
Woodbridge 572
Ashburn 463
Houston 386
Cambridge 342
Nyköping 298
Ann Arbor 281
Seattle 267
Wilmington 236
Singapore 225
Bari 182
Lawrence 174
Roxbury 171
Nanjing 155
Princeton 137
Boardman 128
Des Moines 108
Beijing 94
New York 91
Inglewood 81
Nanchang 49
Hebei 41
Los Angeles 39
Brussels 37
Jiaxing 37
Dearborn 32
San Diego 32
Dublin 31
Tianjin 31
Changsha 29
Helsinki 29
Shenyang 29
Marseille 27
Santa Clara 27
Brooklyn 26
Hong Kong 23
Moscow 23
Washington 23
Frankfurt am Main 22
Guangzhou 22
Toronto 22
Paris 21
Leawood 20
São Paulo 18
Wuhan 18
Augusta 16
Jakarta 16
London 16
Munich 14
Rome 14
Sannicandro di Bari 14
Milan 13
Mumbai 13
Jinan 12
San Francisco 12
Nuremberg 11
Pune 11
Shanghai 11
Genova 10
North Bergen 10
San Mateo 10
Haikou 9
Taranto 9
Tokyo 9
Ardabil 8
Kunming 8
Long Beach 8
Redwood City 8
Belo Horizonte 7
Istanbul 7
Lausanne 7
Monmouth Junction 7
Naples 7
Rio de Janeiro 7
Boydton 6
Council Bluffs 6
Norwalk 6
Osaka 6
Vienna 6
Wuxi 6
Zhengzhou 6
Formello 5
Ningbo 5
Osasco 5
Sydney 5
Taizhou 5
Auburn Hills 4
Bologna 4
Brasília 4
Campinas 4
Delhi 4
Dong Ket 4
Dongjak-gu 4
Gilbert 4
Grottaglie 4
Guys Hill 4
Hefei 4
Juazeiro do Norte 4
Totale 7.563
Salva come PNG Salva come JPEG
Nome #
Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1 149
An efficient synthesis of the optically active isomers of 2H-1,4-benzoxazine derivatives, novel KATP channel modulators 145
Probiotic and Tea Tree Oil Treatments Improve Therapy of Vaginal Candidiasis: A Preliminary Clinical Study 141
Antibiotics - Mentha piperita essential oil synergism inhinibts mature bacterial biofilm 140
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity 132
Kidney CLC-K Chloride Channels Show Differential Pharmacological Profiles Depending on the Heterologous Expression System 132
Activation and inhibition of kidney CLC-K chloride channels by fenamates 129
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 127
Synthesis, in vitro evaluation, and molecular modeling investigation of benzenesulfonimide peroxisome proliferator-activated receptors α antagonists 126
Convenient synthesis of some 3-phenyl-1-benzofuran-2-carboxylic acid derivatives as new potential inhibitors of CLC-Kb channels 125
The effect of nitrogen atoms in the enantioselective oxidation of aryl or heteroaryl benzyl sulfides 120
Carboxylic acids and skeletal muscle chloride channel conductance: Effects on the biological activity induced by the introduction of an aryloxyalkyl group α to the carboxylic function of 4-chloro-phenoxyacetic acid 112
Chemical composition and antibacterial activity of seven uncommon essential oils 111
A Study of Factors Affecting Enantioselectivity in the Oxidation of Aryl Benzyl Sulfides in the Presence of Chiral Titanium Catalysts 109
ANTIDIABETIC AND ANTIOBESITY ACTIVITY OF A NOVEL DUAL PEROXYSOME PROLIFERATOR ACTIVATED RECEPTORS ALPHA/GAMMA LIGAND: A NEW SCAFFOLD MOLECULE DEVOID OF SOME SIDE-EFFECTS OF PPAR LIGANDS? 106
Structural requisites of 2-(p-chlorophenoxy)propionic acid analogues for activity on native rat skeletal muscle chloride conductance and on heterologously expressed CLC-1 103
ChemInform Abstract: Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels. 102
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression 102
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor 101
Open tubular columns containing the immobilized ligand binding domain of peroxisome proliferator-activated receptors α and γ for dual agonists characterization by frontal affinity chromatography with mass spectrometry detection 97
MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY: CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 94
Molecular determinants for the activating/blocking actions of the 2H-1,4-benzoxazine derivatives, a class of potassium channel modulators targeting the skeletal muscle KATP channels 93
Elucidation of the synergistic action of Mentha Piperita essential oil with common antimicrobials 93
ChemInform Abstract: Enantioselective Catalytic Oxidation of (Arylthio)- or (Alkylthio)methylphosphonates as a Route to Enantiomeric Pure Aryl Alkyl or Dialkyl Sulfoxides. 92
Frontal affinity chromatography with MS detection of the ligand binding domain of PPARγ receptor: ligand affinity screening and stereoselective ligand–macromolecule interaction. 89
Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column 88
ChemInform Abstract: Enantio- or Diastereoselective Oxidation of (Methylthio)methylphosphonates as a Route to Precursors of Chiral Sulfoxides. 87
Anti-biofilm inhibitory synergistic effects of combinations of essential oils and antibiotics 87
Enantioselective catalytic oxidation of (arylthio)- or (alkylthio)methylphosphonates as a route to enantiomeric pure aryl alkyl or dialkyl sulfoxides 85
Synthesis, Biological Evaluation, and Molecular Modeling Investigation of Chiral Phenoxyacetic Acid Analogues with PPARalpha and PPARgamma Agonist Activity 84
Procedimento e apparecchiatura per la misurazione del potere anti-infiammatorio di matrici alimentari complesse 84
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study 82
Enantiomeric separation of 2-aryloxyalkyl- and 2-arylalkyl-2-aryloxyacetic acids on a Penicillin G Acylase-based chiral stationary phase: influence of the chemical structure on retention and enantioselectivity 82
A novel carbon leaving group in the reaction of organometallic compounds with phosphine oxides 82
Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity. 81
Comparative analysis of enantioselective separation of novel PPAR agonists by HPLC on cellulose- and amylose-based chiral stationary phases 80
A novel approach to the synthesis of dialkyl or aryl alkyl sulfoxides in high enantiomeric purity 80
AFFINITY OF NEW CHIRAL ARYLOXYALKYLPIPERIDINES TOWARDS σ RECEPTOR SUBTYPES. 79
Crystal structure of the peroxisome proliferator-activated receptor γ (PPARγ) ligand binding domain complexed with a novel partial agonist: A new region of the hydrophobic pocket could be exploited for drug design 79
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 79
Improved lipid metabolism and reduced fat deposition in a mouse model of diet-induced obesity (DIO) with a new dual PPARα/γ ligand 77
Might the observed a2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations? 77
Kidney CLC-K chloride channels inhibitors: structure-based studies and efficacy in hypertension and associated CLC-K polymorphisms. 75
Analoghi degli acidi clofibrici e loro uso come ligandi dei recettori nucleari peroxisome proliferator activated receptor (PPAR) alfa e gamma 74
Attività biologica sui canali KATP del muscolo scheletrico nativo di nuovi e potenti derivati delle 2H-1,4-Benzossazine 74
KIDNEY CLC-K CHLORIDE CHANNELS SHOW DIFFERENTIAL PHARMACOLOGICAL PROFILES DEPENDING ON THE HETEROLOGOUS EXPRESSION SYSTEM 71
Elucidation of the enantioselective recognition mechanism of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxy-2-arylacetic acids 71
Design, synthesis and biological evaluation of a class of bioisosteric oximes of the novel dual peroxisome proliferator-activated receptor alpha/gamma ligand LT175 71
Investigations of pharmacologic properties of the renal CLC-K1 chloride channel co-expressed with barttin by the use of 2-(p-Chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers 69
A novel strategy for the synthesis of chiral nonracemic sulfoxides based upon the displacement of carbanionic leaving groups by organometallic reagents. 68
Exploring the molecular basis of the enantioselective binding of penicillin G acylase towards a series of 2 aryloxyalkanoic acids: A docking and molecular dynamics study 68
Valutazione dell’attività biologica di acidi arilossiacetici a-sostituiti e relativi isosteri 68
Gruppi uscenti di natura carbanionica nelle reazioni di solfossidi e fosfinossidi con reattivi di Grignard. 66
Molecular switch for CLC-K Cl– channel block/activation: Optimal pharmacophoric requirements towards high-affinity ligands 66
Sintesi di una nuova serie di acidi 2-benzofuran-carbossilici a potenziale attività bloccante dei canali al cloro voltaggio-dipendenti CLC-K 64
Evaluation of a penicillin G acylase-based chiral stationary phase towards a series of 2-aryloxyalkanoic acids, isosteric analogs and 2-arylpropionic acids 64
Allyphenyline Analogues Potentially Useful in the Management of Chronic Pain and Opioid Addiction 63
Agonisti dei Recettori Nucleari PPARs come Potenziali Nuovi Agenti Terapeutici per il Trattamento della Sindrome Metabolica 63
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 63
Attività di nuovi analoghi chirali dell'acido clofibrico sui canali al cloro ClC-1 63
Lipases for biocatalysis: development of a chromatographic bioreactor 63
Block of renal CLC-K channels by phenoxy-alkyl derivatives of clofibric acid 62
Antimicrobial Activity of Essential Oils Evaluated In Vitro against Escherichia coli and Staphylococcus aureus 61
BIOLOGICAL ACTIVITY OF NEW POTENT 2H-1,4-BENZOXAZINE DERIVATIVES ON THE NATIVE SKELETAL MUSCLE KATP CHANNEL 61
Studio delle proprietà enentioselettive di una fase stazionaria chirale a base di PGA 61
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors alpha/gamma agonists 61
AGONISTI DEI RECETTORI NUCLEARI PPARs COME POTENZIALI NUOVI AGENTI TERAPEUTICI PER IL TRATTAMENTO DELLA SINDROME METABOLICA. 60
Calcium activated K+ channel as a target of prompt-to-use drugs in neuromuscular disorders 59
Changing the binding mode to peroxisome proliferator activated receptor (PPAR) alpha/gamma: a new ligand with improved antidiabetic and antiobesity properties 59
Affinity of new chiral aryloxyalkylpiperidines towards sigma receptors 59
New clofibric acid analogues with potential activity on PPARs 58
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 58
INNOVATIVE METHODOLOGIES IN NANOTECHNOLOGY FOR THE PREVENTION OF BACTERIAL DISEASES 58
CLC-K kidney chloride channels as drug target for hypertension: effects of acute in vivo administration to rats of newly synthesized inhibitors 58
Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid 58
Diclofenac sodico in associazione con alcuni oli essenziali: evidenza sperimentale in vitro dell'azione sinergica antibiofilm verso diverse specie fungine appartenenti al genere Candida. VI° Congresso Nazionale della Società Italiana per la Ricerca sugli Oli Essenziali. 18-19 ottobre 2019. Dipartimento di Scienze Agro Alimentari dell'Università degli Studi di Bologna. 58
Characterization of two synthetic ligands of peroxisome proliferator-activated receptor (PPAR) by cofactor recruitment, site-directed mutagenesis and structure analysis 57
(contributo in convegno) MOLECULAR DETERMINANTS FOR NUCLEAR RECEPTORS SELECTIVITY; CHEMOMETRIC ANALYSIS, DOCKINGS AND SITE-DIRECTED MUTAGENESIS OF DUAL PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS α/γ AGONISTS 57
In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: A new drug target for hypertension? 57
null 56
Molecular determinants of 2(p-chlorophenoxy)propionic acid for modulation of the native chloride channel conductance of rat skeletal muscle 54
Dimeric analogs of the dual PPARα/γ agonist LT-175: design, synthesis and biological evaluation. 54
Synthesis, SAR, and Biological Evaluation of alpha-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors 52
Structural nucleotide analogs are potent activators/inhibitors of pancreatic beta-cell KATP channels: an emerging mechanism supporting their use as anti-diabetic drugs. 52
Sintesi e valutazione biologica di acidi solfonil fosfonici come inibitori selettivi di MMP-2 51
Development and Application of chromatographic tools based on immobilized PPAR-gamma receptor for binding studies 51
Biological activity of a-substituted-aryloxyacetic acids and their isosteres 51
Analisi conduttimetrica 51
null 49
SINTESI E VALUTAZIONE BIOLOGICA DI DERIVATI SEMI-RIGIDI DELL'ACIDO 2-(4-CLOROFENOSSI)-3-FENIL-PROPANOICO COME BLOCCANTI DEI CANALI AL CLORO VOLTAGGIO-DIPENDENTI CLC-K 49
Studies on the activity of a new ligand of the peroxisome proliferator-activated receptors (PPARs) 48
Sintesi di nuovi analoghi chirali dell’acido clofibrico e valutazione della loro attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alpha e gamma 48
Synthesis, biological evaluation and molecular investigation of fluorinated peroxisome proliferator-activated receptors alpha/gamma dual agonists 48
Virucidal and antiviral effects of Thymus vulgaris essential oil on feline coronavirus 48
Dopamine and Antioxidant Grape Seed Extract loaded chitosan nanoparticles: A preliminary in vitro characterization 47
Synthesis and biological evaluation of alpha sulfonyl phosphonic acids as new MMPs inhibitors 47
Nuovi analoghi chirali dell’acido clofibrico ad attività agonista sui Peroxisome Proliferator-Activated Receptor (PPAR) alfa e gamma 47
Study of the mechanism of action of LT175, a dual PPAR ligand that ameliorates the metabolic profile and insulin sensitivity in different mouse models 47
Niflumic acid derivatives modulate macroscopic chloride conductance of native rat skeletal muscle by inhibiting the CLC-1 channel and by increasing the intracellular calcium level 46
Benzothiazole-Containing Analogues of Triclocarban with Potent Antibacterial Activity 46
Totale 7.651
Salva come PNG Salva come JPEG
Categoria #
all - tutte 51.214
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 51.214
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020273 0 0 0 0 0 0 0 0 0 0 223 50
2020/20211.456 234 58 123 87 167 31 88 62 147 202 160 97
2021/20221.208 44 183 10 34 49 48 54 51 54 55 223 403
2022/20231.992 347 126 107 178 286 262 20 197 376 12 42 39
2023/2024968 67 141 62 59 94 201 40 64 40 53 37 110
2024/20251.668 111 61 255 164 74 218 186 280 151 146 22 0
Totale 11.099