Among neurological disorders, Parkinson’s disease (PD) is one of the most common pathologies affecting over 60-year-old patients in Western Countries. As known, the death of neurons producing the neurotransmitter dopamine (DA) in the Substantia Nigra of the brain is the primary hallmark of the appearance of this disorder. Therefore, much research is devoted to identify strategies for brain DA supply as innovative PD treatment. To overcome this drawback, an interesting option is represented by the development of DA-loaded nanocarriers, which may be able to cross the BBB leading to a sustained delivery of the neurotransmitter to the brain [1-4]. In this communication, we report our preliminary results of a comparative study on DA loaded- Solid Lipid Nanoparticles (SLN) adsorbing a natural antioxidant agent and, precisely, SLN were formed according to the melt homogenization method using Gelucire® 50/13, a self-emulsifying lipid [5,6]. Additionally, herein we have also evaluated the option of a chemical link between the neurotransmitter and a polymeric backbone, leading to a polymer conjugate, to limit the mentioned drawbacks. In this context, some carboxylate chitosan-DA conjugates were synthesized and their potential for improving the brain delivery of the neurotransmitter DA was investigated.
Nose-to-Brain delivery of dopamine via nanocarriers or polymer conjugates: a comparative study
Adriana Trapani;Stefano Castellani;Lorenzo Guerra;Giuseppe Fracchiolla;Maria Luana Poeta;Rosanna Mallamaci;Rosa Angela Cardone;Massimo Conese
2023-01-01
Abstract
Among neurological disorders, Parkinson’s disease (PD) is one of the most common pathologies affecting over 60-year-old patients in Western Countries. As known, the death of neurons producing the neurotransmitter dopamine (DA) in the Substantia Nigra of the brain is the primary hallmark of the appearance of this disorder. Therefore, much research is devoted to identify strategies for brain DA supply as innovative PD treatment. To overcome this drawback, an interesting option is represented by the development of DA-loaded nanocarriers, which may be able to cross the BBB leading to a sustained delivery of the neurotransmitter to the brain [1-4]. In this communication, we report our preliminary results of a comparative study on DA loaded- Solid Lipid Nanoparticles (SLN) adsorbing a natural antioxidant agent and, precisely, SLN were formed according to the melt homogenization method using Gelucire® 50/13, a self-emulsifying lipid [5,6]. Additionally, herein we have also evaluated the option of a chemical link between the neurotransmitter and a polymeric backbone, leading to a polymer conjugate, to limit the mentioned drawbacks. In this context, some carboxylate chitosan-DA conjugates were synthesized and their potential for improving the brain delivery of the neurotransmitter DA was investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
