LENTINI, Giovanni
 Distribuzione geografica
Continente #
NA - Nord America 11.303
EU - Europa 2.927
AS - Asia 1.295
SA - Sud America 15
OC - Oceania 13
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 15.562
Nazione #
US - Stati Uniti d'America 11.288
CN - Cina 1.104
SE - Svezia 809
UA - Ucraina 565
IT - Italia 530
DE - Germania 387
FI - Finlandia 282
GB - Regno Unito 146
FR - Francia 90
SG - Singapore 69
IN - India 44
BE - Belgio 34
IE - Irlanda 34
VN - Vietnam 25
IR - Iran 16
CA - Canada 14
NL - Olanda 12
AU - Australia 8
ID - Indonesia 8
BR - Brasile 7
RU - Federazione Russa 7
JP - Giappone 6
LV - Lettonia 6
NZ - Nuova Zelanda 5
CZ - Repubblica Ceca 4
ES - Italia 4
EU - Europa 4
TR - Turchia 4
CL - Cile 3
KR - Corea 3
NO - Norvegia 3
RO - Romania 3
BO - Bolivia 2
CH - Svizzera 2
EE - Estonia 2
EG - Egitto 2
HK - Hong Kong 2
MY - Malesia 2
RS - Serbia 2
SA - Arabia Saudita 2
TH - Thailandia 2
TW - Taiwan 2
BD - Bangladesh 1
BN - Brunei Darussalam 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
GR - Grecia 1
HR - Croazia 1
HU - Ungheria 1
IL - Israele 1
KH - Cambogia 1
LU - Lussemburgo 1
MA - Marocco 1
MX - Messico 1
PH - Filippine 1
PL - Polonia 1
RE - Reunion 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 15.562
Città #
Fairfield 1.325
Jacksonville 1.311
Chandler 1.229
Woodbridge 965
Ashburn 744
Houston 698
Nyköping 599
Cambridge 529
Seattle 504
Wilmington 452
Ann Arbor 406
Roxbury 298
Lawrence 294
Nanjing 292
Des Moines 192
New York 181
Princeton 166
Boardman 154
Beijing 153
Bari 140
Hebei 73
San Diego 73
Shenyang 71
Nanchang 69
Brooklyn 68
Inglewood 66
Los Angeles 62
Jiaxing 58
Dearborn 44
Singapore 35
Dublin 34
Pune 34
Brussels 33
Changsha 31
Guangzhou 31
Tianjin 31
London 30
Paris 25
Dong Ket 24
Redwood City 24
Rome 24
Jinan 23
Marseille 19
San Mateo 19
Falls Church 16
Leawood 16
Shanghai 16
Wuhan 15
Zhengzhou 15
Ardabil 14
Hefei 14
Helsinki 14
Munich 13
Norwalk 13
San Francisco 13
Washington 13
Milan 11
Ningbo 11
Auburn Hills 10
Toronto 10
Augusta 9
Triggiano 9
Hangzhou 8
Kilburn 8
Wuxi 8
Bitonto 7
Bologna 7
Taizhou 7
Indiana 6
Kansas City 6
Mumbai 6
Naples 6
Qingdao 6
Auckland 5
Brescia 5
Catania 5
Frankfurt am Main 5
Jinhua 5
Melbourne 5
Monmouth Junction 5
Acquaviva delle Fonti 4
Chengdu 4
Chicago 4
Chongqing 4
Florence 4
Fuzhou 4
Kunming 4
Madrid 4
Noci 4
Palermo 4
Riga 4
Siena 4
Tappahannock 4
Tokyo 4
Belém 3
Chatsworth 3
Council Bluffs 3
Islington 3
Kiev 3
Oslo 3
Totale 12.049
Nome #
Acidi carbossilici derivati dell'antracene e suoi isosteri: effetti sulla conduttanza al cloro 133
Positional isomers of mannose-quinoline conjugates and their copper complexes: Exploring the biological activity 116
Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin 116
A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells 115
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 114
The chemistry and pharmacology of citrus limonoids 110
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma 109
2,6-xilididi e b-2,6,-xililossietilammine come ligandi anfipatici per i recettori benzodiazepinici di tipo mitocondriale 108
Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents 107
Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods 107
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II 106
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 106
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 105
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs 105
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers 102
Recent trends in the discovery of small molecule blockers of sodium channels 100
Facile entry to (-)-R- and (+)-(S)-mexiletine 99
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II 99
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 99
Fitocomplesso polifenolico standardizzato per la prevenzione delle patologie correlate all’esposizione da sostanze reattive dell’ossigeno e relativo metodo di produzione 95
Pharmacological differences between R(-) and S(+) Tocainide 94
The practice of medicinal chemistry 93
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 93
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites 93
The effects of tocainide and its chiral analogs on sodium channels of human muscle 92
Le applicazioni della chimica farmaceutica 92
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 92
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 90
null 90
Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity 90
Old drug scaffold, new activity: Thalidomide-correlated compounds exert different effects on breast cancer cell growth and progression 89
2-Arylazetidines as ligands for nicotinic acetylcholine receptors 88
Trivial, common, and systematic chemical names 87
Pharmacological differences between R(-) and S(+) Tocainide 87
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones 85
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 85
A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues 85
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 83
The therapeutic potential of rutin for diabetes: An update 82
Pharmacological differences between R(-) and S(+) tocainide 81
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 81
Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens 81
New doxorubicin nanocarriers based on cyclodextrins 80
Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination 80
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 80
Stereospecific synthesis and absolute configuration of Mexiletine 79
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 78
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 78
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate 77
Ebola therapy: Developing new drugs or repurposing old ones? 77
null 77
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors 76
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 75
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 75
null 75
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 74
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 74
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents 74
Pharmacological differences between R(-) and S(+) tocainide 73
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 73
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 72
Discovery of a new mexiletine-derived agonist of the hERG K+channel 72
Phytochemical, Antioxidant and Anti-a-glucosidase Activity Evaluations of Bergenia cordifolia 72
Comment on "in Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach" 72
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 71
Antimyotonic effects of enantiomers of mexiletine-like drugs 71
Lubeluzole: from anti-ischemic to chemosensitizing agent 71
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction 70
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 70
The trivial names of citrus limonoids 69
Activity of natural hydroxytyrosol versus a synthetic sample and its chiral analogues: hypothesis on mechanism of action. 68
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 68
null 68
2-(9-Antryl)alcanoic acids as chloride channel modulators 68
Did ebola survivors use plant medicines, and if so, which ones? 68
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition 68
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 67
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 67
Contribution to the study of 2-aryloxy-1-phenyl- and 2-aryloxy-2-phenylethanols. Differentiation by mass spectrometry 66
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 66
Shouldn’t enantiomeric purity be included in the ‘minimum information about a bioactive entity’? 65
alpha-Glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 65
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 64
Analisi Farmaceutica 64
null 64
Stereoselectivity in central analgesic action of Tocainide and its analogs 63
Analoghi chirali della Tocainide: attività analgesica centrale 63
(2) Save to: more options Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 63
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite 63
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 63
Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate 63
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine 62
null 61
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 60
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole 60
Analoghi chirali della mexiletina: blocco stereoselettivo dei canali per gli ioni sodio e ipotesi sull’interazione recettoriale 59
Analoghi rigidi della Tocainide: 2',6'-Prolinoxilidide e suoi derivati 59
Therapeutic effects of tocainide and mexiletine analogs on myotonic MTO and ADR mice 58
Alpha-glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 58
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 58
Totale 8.078
Categoria #
all - tutte 66.578
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 66.578


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.897 0 266 80 257 375 182 388 224 466 170 418 71
2020/20212.736 452 108 258 142 285 111 231 131 285 374 208 151
2021/20221.990 89 333 36 96 48 100 71 98 115 118 309 577
2022/20233.325 546 289 174 306 432 444 32 397 525 24 86 70
2023/20241.336 94 233 54 102 70 287 35 76 35 46 149 155
2024/2025244 172 72 0 0 0 0 0 0 0 0 0 0
Totale 16.051