IRIS
LENTINI, Giovanni
 Distribuzione geografica
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Continente #
NA - Nord America 11.605
EU - Europa 3.836
AS - Asia 2.165
SA - Sud America 362
AF - Africa 21
OC - Oceania 14
Continente sconosciuto - Info sul continente non disponibili 4
Totale 18.007
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Nazione #
US - Stati Uniti d'America 11.560
CN - Cina 1.149
SE - Svezia 804
SG - Singapore 721
IT - Italia 642
RU - Federazione Russa 608
UA - Ucraina 569
DE - Germania 442
BR - Brasile 318
FI - Finlandia 316
GB - Regno Unito 167
FR - Francia 111
IN - India 55
ID - Indonesia 49
BE - Belgio 40
HK - Hong Kong 39
CA - Canada 37
IE - Irlanda 35
TR - Turchia 35
VN - Vietnam 25
NL - Olanda 22
IR - Iran 18
AT - Austria 17
LT - Lituania 14
JP - Giappone 12
PK - Pakistan 10
AR - Argentina 9
AU - Australia 9
BD - Bangladesh 8
CO - Colombia 8
PL - Polonia 7
LV - Lettonia 6
MA - Marocco 6
MX - Messico 6
RO - Romania 6
UZ - Uzbekistan 6
VE - Venezuela 6
ZA - Sudafrica 6
CZ - Repubblica Ceca 5
ES - Italia 5
NZ - Nuova Zelanda 5
PH - Filippine 5
UY - Uruguay 5
BO - Bolivia 4
CL - Cile 4
EC - Ecuador 4
EU - Europa 4
KR - Corea 4
CH - Svizzera 3
EG - Egitto 3
NO - Norvegia 3
PE - Perù 3
PT - Portogallo 3
SA - Arabia Saudita 3
TH - Thailandia 3
TW - Taiwan 3
AE - Emirati Arabi Uniti 2
EE - Estonia 2
GE - Georgia 2
HU - Ungheria 2
IL - Israele 2
IQ - Iraq 2
KE - Kenya 2
MY - Malesia 2
OM - Oman 2
PS - Palestinian Territory 2
RS - Serbia 2
AZ - Azerbaigian 1
BA - Bosnia-Erzegovina 1
BN - Brunei Darussalam 1
DK - Danimarca 1
DO - Repubblica Dominicana 1
FK - Isole Falkland (Malvinas) 1
GA - Gabon 1
GR - Grecia 1
HR - Croazia 1
KG - Kirghizistan 1
KH - Cambogia 1
KW - Kuwait 1
LB - Libano 1
LU - Lussemburgo 1
RE - Reunion 1
SN - Senegal 1
TN - Tunisia 1
TT - Trinidad e Tobago 1
Totale 18.007
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Città #
Fairfield 1.325
Jacksonville 1.311
Chandler 1.219
Woodbridge 965
Ashburn 746
Houston 698
Nyköping 594
Cambridge 529
Seattle 505
Wilmington 452
Ann Arbor 406
Singapore 385
Roxbury 298
Lawrence 294
Nanjing 292
Bari 196
Des Moines 190
New York 181
Boardman 166
Princeton 166
Beijing 155
Hebei 73
San Diego 73
Shenyang 71
Nanchang 69
Brooklyn 68
Inglewood 66
Los Angeles 65
Jiaxing 58
Moscow 56
Santa Clara 55
Helsinki 48
Dearborn 44
Jakarta 41
Brussels 39
Guangzhou 38
London 38
Dublin 35
Pune 34
Changsha 33
Hong Kong 33
Tianjin 31
Rome 30
North Bergen 28
Dong Ket 24
Jinan 24
Paris 24
Redwood City 24
Toronto 23
Munich 21
Frankfurt am Main 20
Marseille 19
San Mateo 19
Council Bluffs 18
Shanghai 17
Falls Church 16
Leawood 16
Milan 15
São Paulo 15
Wuhan 15
Zhengzhou 15
Ardabil 14
Hefei 14
Istanbul 13
Norwalk 13
San Francisco 13
Washington 13
Düsseldorf 11
Ningbo 11
Rio de Janeiro 11
Auburn Hills 10
Hangzhou 10
Augusta 9
Falkenstein 9
Triggiano 9
Kilburn 8
Ottawa 8
Tokyo 8
Wuxi 8
Bologna 7
Mumbai 7
Naples 7
Portsmouth 7
Taizhou 7
Vienna 7
Bitonto 6
Chicago 6
Indiana 6
Kansas City 6
Nuremberg 6
Qingdao 6
Auckland 5
Belo Horizonte 5
Belém 5
Betim 5
Brescia 5
Catania 5
Curitiba 5
Faisalabad 5
Florence 5
Totale 12.839
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Nome #
Acidi carbossilici derivati dell'antracene e suoi isosteri: effetti sulla conduttanza al cloro 146
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 127
A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells 126
Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin 126
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma 123
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 122
Positional isomers of mannose-quinoline conjugates and their copper complexes: Exploring the biological activity 122
Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods 122
2,6-xilididi e b-2,6,-xililossietilammine come ligandi anfipatici per i recettori benzodiazepinici di tipo mitocondriale 119
The chemistry and pharmacology of citrus limonoids 117
Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents 116
Fitocomplesso polifenolico standardizzato per la prevenzione delle patologie correlate all’esposizione da sostanze reattive dell’ossigeno e relativo metodo di produzione 116
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 115
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II 114
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II 113
Recent trends in the discovery of small molecule blockers of sodium channels 112
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs 112
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 109
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers 108
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites 108
Facile entry to (-)-R- and (+)-(S)-mexiletine 105
Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens 103
The practice of medicinal chemistry 102
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 102
A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues 102
2-Arylazetidines as ligands for nicotinic acetylcholine receptors 101
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 101
Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity 100
Pharmacological differences between R(-) and S(+) Tocainide 99
Old drug scaffold, new activity: Thalidomide-correlated compounds exert different effects on breast cancer cell growth and progression 98
Le applicazioni della chimica farmaceutica 97
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 97
The effects of tocainide and its chiral analogs on sodium channels of human muscle 96
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 93
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 93
Pharmacological differences between R(-) and S(+) Tocainide 92
Trivial, common, and systematic chemical names 91
null 91
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones 90
The therapeutic potential of rutin for diabetes: An update 89
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 89
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate 88
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 88
Pharmacological differences between R(-) and S(+) tocainide 87
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 86
Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination 85
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 85
Stereospecific synthesis and absolute configuration of Mexiletine 84
New doxorubicin nanocarriers based on cyclodextrins 84
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 83
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 83
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 82
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors 82
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents 82
Ebola therapy: Developing new drugs or repurposing old ones? 81
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 80
Activity of natural hydroxytyrosol versus a synthetic sample and its chiral analogues: hypothesis on mechanism of action. 80
Discovery of a new mexiletine-derived agonist of the hERG K+channel 80
Comment on "in Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach" 80
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 79
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 79
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 79
2-(9-Antryl)alcanoic acids as chloride channel modulators 78
null 78
Phytochemical, Antioxidant and Anti-a-glucosidase Activity Evaluations of Bergenia cordifolia 78
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition 78
Pharmacological differences between R(-) and S(+) tocainide 77
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction 77
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 77
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 76
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 76
Antimyotonic effects of enantiomers of mexiletine-like drugs 76
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite 76
alpha-Glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 76
null 76
Lubeluzole: from anti-ischemic to chemosensitizing agent 75
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 74
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 73
Analoghi chirali della Tocainide: attività analgesica centrale 73
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 73
Analisi Farmaceutica 72
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 72
Analoghi rigidi della Tocainide: 2',6'-Prolinoxilidide e suoi derivati 71
The trivial names of citrus limonoids 71
Did ebola survivors use plant medicines, and if so, which ones? 71
Shouldn’t enantiomeric purity be included in the ‘minimum information about a bioactive entity’? 71
Contribution to the study of 2-aryloxy-1-phenyl- and 2-aryloxy-2-phenylethanols. Differentiation by mass spectrometry 70
(2) Save to: more options Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 70
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 70
Analoghi chirali della mexiletina: blocco stereoselettivo dei canali per gli ioni sodio e ipotesi sull’interazione recettoriale 69
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole 69
Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities 69
a-Glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 68
null 68
Stereoselectivity in central analgesic action of Tocainide and its analogs 68
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 68
Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate 68
Activity of natural hydroxytyrosol versus a synthetic sample and its chiral analogues: hypotesis on mechanism of action 68
Risoluzione cinetica parziale dell'acido 2-fenilbutirrico con alpha-ariletilammine omochirali: condizioni sperimentali e stereoselettività 67
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine 67
Totale 8.895
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Categoria #
all - tutte 85.473
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 85.473
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020489 0 0 0 0 0 0 0 0 0 0 418 71
2020/20212.736 452 108 258 142 285 111 231 131 285 374 208 151
2021/20221.987 89 333 36 96 48 100 71 98 115 118 308 575
2022/20233.306 545 285 172 305 431 441 31 395 523 24 84 70
2023/20241.323 94 231 52 99 67 286 35 74 35 46 149 155
2024/20252.836 168 106 451 162 130 384 394 496 261 263 21 0
Totale 18.608