IRIS
LENTINI, Giovanni
 Distribuzione geografica
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Continente #
NA - Nord America 11.512
EU - Europa 3.001
AS - Asia 1.714
SA - Sud America 17
OC - Oceania 13
AF - Africa 5
Continente sconosciuto - Info sul continente non disponibili 4
Totale 16.266
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Nazione #
US - Stati Uniti d'America 11.486
CN - Cina 1.123
SE - Svezia 806
UA - Ucraina 565
IT - Italia 553
SG - Singapore 457
DE - Germania 399
FI - Finlandia 295
GB - Regno Unito 152
FR - Francia 89
IN - India 48
BE - Belgio 37
IE - Irlanda 34
CA - Canada 25
VN - Vietnam 25
IR - Iran 16
NL - Olanda 15
LT - Lituania 10
AU - Australia 8
ID - Indonesia 8
JP - Giappone 8
BR - Brasile 7
RU - Federazione Russa 7
LV - Lettonia 6
RO - Romania 6
NZ - Nuova Zelanda 5
TR - Turchia 5
CZ - Repubblica Ceca 4
ES - Italia 4
EU - Europa 4
HK - Hong Kong 4
KR - Corea 4
CL - Cile 3
NO - Norvegia 3
PL - Polonia 3
PT - Portogallo 3
TW - Taiwan 3
BO - Bolivia 2
CH - Svizzera 2
CO - Colombia 2
EE - Estonia 2
EG - Egitto 2
MY - Malesia 2
RS - Serbia 2
SA - Arabia Saudita 2
TH - Thailandia 2
AZ - Azerbaigian 1
BD - Bangladesh 1
BN - Brunei Darussalam 1
EC - Ecuador 1
FK - Isole Falkland (Malvinas) 1
GE - Georgia 1
GR - Grecia 1
HR - Croazia 1
HU - Ungheria 1
IL - Israele 1
KH - Cambogia 1
LU - Lussemburgo 1
MA - Marocco 1
MX - Messico 1
PH - Filippine 1
RE - Reunion 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 16.266
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Città #
Fairfield 1.325
Jacksonville 1.311
Chandler 1.219
Woodbridge 965
Ashburn 744
Houston 698
Nyköping 596
Cambridge 529
Seattle 504
Wilmington 452
Ann Arbor 406
Singapore 347
Roxbury 298
Lawrence 294
Nanjing 292
Des Moines 191
New York 181
Boardman 166
Princeton 166
Beijing 155
Bari 146
Hebei 73
San Diego 73
Shenyang 71
Nanchang 69
Brooklyn 68
Inglewood 66
Los Angeles 62
Jiaxing 58
Santa Clara 55
Dearborn 44
Brussels 36
Dublin 34
Pune 34
Changsha 33
London 33
Guangzhou 31
Tianjin 31
Helsinki 27
Dong Ket 24
Jinan 24
Paris 24
Redwood City 24
Rome 24
Munich 21
Marseille 19
San Mateo 19
Toronto 17
Falls Church 16
Leawood 16
Shanghai 15
Wuhan 15
Zhengzhou 15
Ardabil 14
Hefei 14
Milan 14
Norwalk 13
San Francisco 13
Washington 13
Ningbo 11
Auburn Hills 10
Augusta 9
Triggiano 9
Frankfurt am Main 8
Hangzhou 8
Kilburn 8
Wuxi 8
Bologna 7
Mumbai 7
Naples 7
Taizhou 7
Bitonto 6
Chicago 6
Indiana 6
Kansas City 6
Qingdao 6
Tokyo 6
Auckland 5
Brescia 5
Catania 5
Jinhua 5
Melbourne 5
Monmouth Junction 5
Acquaviva delle Fonti 4
Chengdu 4
Chongqing 4
Florence 4
Fuzhou 4
Kunming 4
Madrid 4
Noci 4
Palermo 4
Riga 4
Tappahannock 4
Belém 3
Chatsworth 3
Council Bluffs 3
Islington 3
Kiev 3
Oslo 3
Totale 12.464
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Nome #
Acidi carbossilici derivati dell'antracene e suoi isosteri: effetti sulla conduttanza al cloro 138
Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin 122
Positional isomers of mannose-quinoline conjugates and their copper complexes: Exploring the biological activity 120
A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells 119
Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods 117
Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods 113
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma 112
2,6-xilididi e b-2,6,-xililossietilammine come ligandi anfipatici per i recettori benzodiazepinici di tipo mitocondriale 111
The chemistry and pharmacology of citrus limonoids 111
Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents 110
(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate 110
Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo 108
The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II 107
Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs 107
Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers 106
Recent trends in the discovery of small molecule blockers of sodium channels 104
Facile entry to (-)-R- and (+)-(S)-mexiletine 102
N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II 102
Fitocomplesso polifenolico standardizzato per la prevenzione delle patologie correlate all’esposizione da sostanze reattive dell’ossigeno e relativo metodo di produzione 101
Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine 100
Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites 98
Pharmacological differences between R(-) and S(+) Tocainide 97
Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres 95
The practice of medicinal chemistry 94
The effects of tocainide and its chiral analogs on sodium channels of human muscle 93
Le applicazioni della chimica farmaceutica 93
Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II 93
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity 93
2-Arylazetidines as ligands for nicotinic acetylcholine receptors 92
Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity 92
Old drug scaffold, new activity: Thalidomide-correlated compounds exert different effects on breast cancer cell growth and progression 91
null 90
A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues 90
Trivial, common, and systematic chemical names 89
Pharmacological differences between R(-) and S(+) Tocainide 89
Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens 89
Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones 88
Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules 86
Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity 85
The therapeutic potential of rutin for diabetes: An update 84
Pharmacological differences between R(-) and S(+) tocainide 83
Molecular determinants of state dependent block of voltage-gated sodium channels by pilsicainide 83
Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design 83
Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination 82
Stereospecific synthesis and absolute configuration of Mexiletine 81
Facile, alternative route to Lubeluzole, its enantiomer, and the racemate 80
New doxorubicin nanocarriers based on cyclodextrins 80
Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues 80
Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 79
Ebola therapy: Developing new drugs or repurposing old ones? 78
Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors 78
Molecular Determinants of Human Voltage-Gated Sodium Channels Blockade by Lubeluzole 77
Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide 77
null 77
One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents 77
Arilossialchilammine come ligandi per i recettori 5-HT1B/1D: Bioisosteria, chiralità e selettività 76
Pharmacological differences between R(-) and S(+) tocainide 76
Stereospecific Synthesis of ‘‘para-Hydroxymexiletine’’ and Sodium Channel Blocking Activity Evaluation 76
New potent mexiletine and tocainide analogues evaluated in vivo and in vitro as antimyotonic agents on the myotonic ADR mouse 75
Discovery of a new mexiletine-derived agonist of the hERG K+channel 75
Phytochemical, Antioxidant and Anti-a-glucosidase Activity Evaluations of Bergenia cordifolia 75
Comment on "in Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach" 75
null 75
Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective 74
Antimyotonic effects of enantiomers of mexiletine-like drugs 73
Lubeluzole: from anti-ischemic to chemosensitizing agent 73
Optically active Mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels 72
Activity of natural hydroxytyrosol versus a synthetic sample and its chiral analogues: hypothesis on mechanism of action. 72
Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction 72
Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials 71
Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na+ channels with increased potency and improved use-dependent activity 70
2-(9-Antryl)alcanoic acids as chloride channel modulators 70
Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential 70
The trivial names of citrus limonoids 69
Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition 69
null 68
Contribution to the study of 2-aryloxy-1-phenyl- and 2-aryloxy-2-phenylethanols. Differentiation by mass spectrometry 68
Did ebola survivors use plant medicines, and if so, which ones? 68
Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels 68
alpha-Glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 68
Antioxidant activity of Uva di Troia ad acino piccolo: comparison of different extraction methods 67
Analisi Farmaceutica 67
Shouldn’t enantiomeric purity be included in the ‘minimum information about a bioactive entity’? 67
Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine 67
Analoghi chirali della Tocainide: attività analgesica centrale 66
(2) Save to: more options Isosteric derivates of mexiletine: New potent use-dependent blockers of skeletal muscle sodium channels with potential antimyotonic activity 66
Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate 66
Stereoselectivity in central analgesic action of Tocainide and its analogs 65
An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite 65
Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs 65
null 64
Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine 63
Analoghi rigidi della Tocainide: 2',6'-Prolinoxilidide e suoi derivati 63
A new benzylated proline-like tocainide derivative is a potent use dependent skeletal muscle Na+ channel blocker with a potential antimyotonic activity 63
Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole 63
Analoghi chirali della mexiletina: blocco stereoselettivo dei canali per gli ioni sodio e ipotesi sull’interazione recettoriale 62
Alpha-glucosidase inhibitors: SAR studies on N-(aryloxyalkyl)phthalimides and their isosters 62
Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity 62
Therapeutic effects of tocainide and mexiletine analogs on myotonic MTO and ADR mice 61
Chiral mexiletine analogues as skeletal muscle voltage-gated sodium channel blocking agents 61
Totale 8.319
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Categoria #
all - tutte 73.972
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 73.972
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.294 0 0 0 0 375 182 388 224 466 170 418 71
2020/20212.736 452 108 258 142 285 111 231 131 285 374 208 151
2021/20221.988 89 333 36 96 48 100 71 98 115 118 309 575
2022/20233.308 545 285 172 305 431 442 31 396 523 24 84 70
2023/20241.329 94 231 53 101 68 286 35 76 35 46 149 155
2024/2025989 168 106 451 162 102 0 0 0 0 0 0 0
Totale 16.770