| Nome |
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A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma, file dd9e0c6c-8f15-1e9c-e053-3a05fe0a45ef
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228
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Microwave assisted synthesis of (±)-mandelic acid-d5, optical resolution, and absolute configuration determination, file dd9e0c64-1ac7-1e9c-e053-3a05fe0a45ef
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207
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The therapeutic potential of rutin for diabetes: An update, file dd9e0c6c-84fa-1e9c-e053-3a05fe0a45ef
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180
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Microwave-assisted synthesis of KN-93, a potent and selective inhibitor of Ca2+/calmoduline-dependent protein kinase II, file dd9e0c67-c9bf-1e9c-e053-3a05fe0a45ef
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161
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Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective, file 7ca2e81b-3d8d-41a6-a015-2aa1d9ba1ad8
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108
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Plant-derived anticancer agents: Lessons from the pharmacology of geniposide and its aglycone, genipin, file dd9e0c65-894a-1e9c-e053-3a05fe0a45ef
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76
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Repurposing therapeutic agents and herbal medicines to defeat viral nemesis, file dd9e0c67-885d-1e9c-e053-3a05fe0a45ef
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73
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The chemistry and pharmacology of citrus limonoids, file dd9e0c64-1a58-1e9c-e053-3a05fe0a45ef
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68
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Covid-19, chloroquine repurposing, and cardiac safety concern: Chirality might help, file dd9e0c67-5ee8-1e9c-e053-3a05fe0a45ef
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64
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Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition, file dd9e0c64-931f-1e9c-e053-3a05fe0a45ef
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62
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Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine, file dd9e0c64-ff31-1e9c-e053-3a05fe0a45ef
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60
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Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres, file dd9e0c62-a22c-1e9c-e053-3a05fe0a45ef
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56
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Optimization of microwave-assisted extraction of antioxidants from bamboo shoots of Phyllostachys pubescens, file dd9e0c66-bef8-1e9c-e053-3a05fe0a45ef
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54
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Old drug scaffold, new activity: Thalidomide-correlated compounds exert different effects on breast cancer cell growth and progression, file 2d6c5ba5-26d8-4ee2-88ca-f99504a3f7f5
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47
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Dual action of mexiletine and its pyrroline derivatives as skeletal muscle sodium channel blockers and anti-oxidant compounds: Toward novel therapeutic potential, file dd9e0c64-d179-1e9c-e053-3a05fe0a45ef
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46
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Antimicrobial and antibiofilm activities of citrus water-extracts obtained by microwave-assisted and conventional methods, file dd9e0c65-8a4f-1e9c-e053-3a05fe0a45ef
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45
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New doxorubicin nanocarriers based on cyclodextrins, file 86d5b657-d377-4bf4-b1c0-4aa42f259977
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44
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Crystal structure of N-(2-{[(2E)-3-(4-chlorophenyl)-2-propenyl]-(methyl)ammonio}methylphenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide dihydrogenphosphate — methanol (1:1), [C26H30ClN2SO4][H2PO4] × CH4O, file dd9e0c62-667d-1e9c-e053-3a05fe0a45ef
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43
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Molecular Insights into hERG Potassium Channel Blockade by Lubeluzole, file dd9e0c65-41a6-1e9c-e053-3a05fe0a45ef
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28
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Bioisosteric Modification of To042: Synthesis and Evaluation of Promising Use-Dependent Inhibitors of Voltage-Gated Sodium Channels, file dd9e0c6b-45e6-1e9c-e053-3a05fe0a45ef
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15
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A Focus on the Synthesis and Pharmacokinetics of Tocainide and its Analogues, file dd9e0c67-e099-1e9c-e053-3a05fe0a45ef
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13
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Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c6c-84df-1e9c-e053-3a05fe0a45ef
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9
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Stereoselective Modulation of P-Glycoprotein by Chiral Small Molecules, file dd9e0c62-f60d-1e9c-e053-3a05fe0a45ef
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8
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null, file dd9e0c68-0886-1e9c-e053-3a05fe0a45ef
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8
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Molecular insights into the local anesthetic receptor within voltage-gated sodium channels using hydroxylated analogs of mexiletine, file dd9e0c62-a8ed-1e9c-e053-3a05fe0a45ef
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7
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Ligand efficiency metrics in drug discovery: the pros and cons from a practical perspective, file dd9e0c64-f1c2-1e9c-e053-3a05fe0a45ef
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7
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Human ether-à-go-go-related potassium channel: exploring SAR to improve drug design, file dd9e0c66-64ee-1e9c-e053-3a05fe0a45ef
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7
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Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by n-benzyl analogs of tocainide-like compounds, file dd9e0c68-da6a-1e9c-e053-3a05fe0a45ef
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7
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Erratum: Optically Active Mexiletine Analogues as Stereoselective Blockers of Voltage-Gated Na+ Channels, file dd9e0c62-871f-1e9c-e053-3a05fe0a45ef
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6
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A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells, file dd9e0c63-5319-1e9c-e053-3a05fe0a45ef
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6
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Capillary zone electrophoresis for separation and quantitative determination of mexiletine and its main phase i metabolites, file dd9e0c64-1d78-1e9c-e053-3a05fe0a45ef
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6
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Discovery of a new mexiletine-derived agonist of the hERG K+channel, file dd9e0c64-f107-1e9c-e053-3a05fe0a45ef
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6
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Inhibition of skeletal muscle sodium currents by Mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile, file dd9e0c68-da70-1e9c-e053-3a05fe0a45ef
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6
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From riluzole to dexpramipexole via substituted-benzothiazole derivatives for amyotrophic lateral sclerosis disease treatment: Case studies, file 4c45e388-8681-4378-975a-934cba28b104
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5
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Synthesis and evaluation of berberine derivatives and analogs as potential antiacetylcholinesterase and antioxidant agents, file dd9e0c64-19e6-1e9c-e053-3a05fe0a45ef
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5
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A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma, file dd9e0c64-c251-1e9c-e053-3a05fe0a45ef
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5
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Facile, alternative route to Lubeluzole, its enantiomer, and the racemate, file dd9e0c65-af03-1e9c-e053-3a05fe0a45ef
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5
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Preparation of (–)-(R)-2-(2,3,4,5,6-pentafluorophenoxy)-2-(phenyl-d5)acetic acid: an efficient 1H NMR chiral solvating agent for direct enantiomeric purity evaluation of quinoline-containing antimalarial drugs, file dd9e0c63-32a0-1e9c-e053-3a05fe0a45ef
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4
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Old drug scaffold, new activity: Thalidomide-correlated compounds exert different effects on breast cancer cell growth and progression, file dd9e0c64-171b-1e9c-e053-3a05fe0a45ef
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4
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Recent trends in the discovery of small molecule blockers of sodium channels, file dd9e0c64-225c-1e9c-e053-3a05fe0a45ef
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4
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N-(Phenoxyalkyl)amides as MT1 and MT2 ligands: Antioxidant properties and inhibition of Ca2+/CaM-dependent kinase II, file dd9e0c64-2a77-1e9c-e053-3a05fe0a45ef
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4
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null, file dd9e0c64-2a7d-1e9c-e053-3a05fe0a45ef
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4
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Synthesis of (R)-, (S)-, and (RS)-hydroxymethylmexiletine one of the major metabolites of mexiletine, file dd9e0c65-b0a6-1e9c-e053-3a05fe0a45ef
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4
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Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na+ channels enhancing the antimyotonic activity in vivo, file dd9e0c65-f6d6-1e9c-e053-3a05fe0a45ef
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4
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Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function, file dd9e0c66-5e61-1e9c-e053-3a05fe0a45ef
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4
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Targeting the pregnane X receptor using microbial metabolite mimicry, file dd9e0c66-befa-1e9c-e053-3a05fe0a45ef
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4
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Searching for new antiarrhythmic agents: evaluation of meta-hydroxymexiletine enantiomers, file dd9e0c67-cd44-1e9c-e053-3a05fe0a45ef
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4
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First synthesis and full characterization of mexiletine N-carbonyloxy beta-D-glucuronide, file dd9e0c68-0eb7-1e9c-e053-3a05fe0a45ef
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4
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Combined modifications of mexiletine pharmacophores for new lead blockers of Nav1.4 channels, file dd9e0c68-fe80-1e9c-e053-3a05fe0a45ef
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4
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The chemosensitizing agent lubeluzole binds calmodulin and inhibits Ca2+/calmodulin-dependent Kinase II, file dd9e0c63-5a60-1e9c-e053-3a05fe0a45ef
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3
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Synthesis, antiarrhythmic activity, and toxicological evaluation of mexiletine analogues, file dd9e0c63-b970-1e9c-e053-3a05fe0a45ef
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3
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null, file dd9e0c64-ae82-1e9c-e053-3a05fe0a45ef
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3
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null, file dd9e0c65-8948-1e9c-e053-3a05fe0a45ef
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3
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Enzymatic Resolution of α-Methyleneparaconic Acids and Evaluation of their Biological Activity, file dd9e0c65-e566-1e9c-e053-3a05fe0a45ef
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3
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Antioxidant Activity of Uva di Troia Canosina: Comparison of Two Extraction Methods, file dd9e0c66-03c4-1e9c-e053-3a05fe0a45ef
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3
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Optically active mexiletine analogues as stereoselective blockers of voltage-gated Na+ channels, file dd9e0c67-d164-1e9c-e053-3a05fe0a45ef
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3
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Pilsicainide and its oxymethylene analog: Facile alternative synthesis and in vitro testing on human skeletal muscle sodium channels, file dd9e0c67-d710-1e9c-e053-3a05fe0a45ef
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3
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One-step synthesis of homochiral O-aryl and O-heteroaryl mandelic acids and their use as efficient 1H NMR chiral solvating agents, file dd9e0c67-db72-1e9c-e053-3a05fe0a45ef
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3
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(S)-ethyl 2-(tert-butoxycarbonylamino)-3-(2-iodo-4,5-methylenedioxyphenyl)propanoate, file dd9e0c68-05e8-1e9c-e053-3a05fe0a45ef
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3
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New N-(phenoxydecyl)phthalimide derivatives displaying potent inhibition activity towards alpha-glucosidase, file dd9e0c68-2199-1e9c-e053-3a05fe0a45ef
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3
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Synthesis and Evaluation of Voltage-Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities, file dd9e0c6a-ca70-1e9c-e053-3a05fe0a45ef
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3
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null, file dd9e0c62-6ce2-1e9c-e053-3a05fe0a45ef
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2
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The therapeutic potential of rutin for diabetes: An update, file dd9e0c64-2228-1e9c-e053-3a05fe0a45ef
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2
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|
null, file dd9e0c64-b45c-1e9c-e053-3a05fe0a45ef
|
2
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2-Arylazetidines as ligands for nicotinic acetylcholine receptors, file dd9e0c64-e49b-1e9c-e053-3a05fe0a45ef
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2
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Newly synthesized mexiletine and tocainide analogues are potent use-dependent blockers of skeletal muscle sodium channels: potential implication for antimyotonic activity, file dd9e0c66-a4ef-1e9c-e053-3a05fe0a45ef
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2
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Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity, file dd9e0c68-05e5-1e9c-e053-3a05fe0a45ef
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2
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New doxorubicin nanocarriers based on cyclodextrins, file dd9e0c68-dfce-1e9c-e053-3a05fe0a45ef
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2
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null, file dd9e0c68-e344-1e9c-e053-3a05fe0a45ef
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2
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Evaluation of the pharmacological activity of the major mexiletine metabolites on skeletal muscle sodium currents, file dd9e0c68-fe77-1e9c-e053-3a05fe0a45ef
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2
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Inverse Virtual Screening for the rapid re-evaluation of the presumed biological safe profile of natural products. The case of steviol from Stevia rebaudiana glycosides on farnesoid X receptor (FXR), file dd9e0c6b-7794-1e9c-e053-3a05fe0a45ef
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2
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Densely Functionalized 2-Methylideneazetidines: Evaluation as Antibacterials, file dd9e0c6b-8d1b-1e9c-e053-3a05fe0a45ef
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2
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Lubeluzole: from anti-ischemic drug to preclinical antidiarrheal studies, file dd9e0c6b-a18d-1e9c-e053-3a05fe0a45ef
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2
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Biostimulant Formulations and Moringa oleifera Extracts to Improve Yield, Quality, and Storability of Hydroponic Lettuce, file 000798d7-6205-4aca-a6ec-78609dd23922
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1
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hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation, file 08429c2b-f35c-4bbe-a13d-9622843e604c
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1
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|
Targeting Penicillium expansum GMC oxidoreductase with high affinity small molecules for reducing patulin production, file 12e0780f-5f6f-4853-bc04-4eabc5f761f1
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1
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Structure-Based Prediction of hERG-Related Cardiotoxicity: A Benchmark Study, file 2cfb3ed7-023b-4b59-bd40-d164c90da32f
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1
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Targeting mitochondrial impairment for the treatment of cardiovascular diseases: from hypertension to ischemiareperfusion injury, searching for new pharmacological targets, file 3a4af421-0e27-47bb-8bd4-c3e139cce483
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1
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Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs, file 72a1f078-56cc-4c00-aed5-aaad2fac23b2
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1
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Stereospecific synthesis of Mexiletine and related compounds: Mitsunobu versus Williamson condensation reaction, file dd9e0c62-7dbb-1e9c-e053-3a05fe0a45ef
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1
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Small Molecules as MT1 And MT2 Ligands: Antioxidant Properties and in vitro Inhibition of Ca2+/CAM-Dependent Kinase II., file dd9e0c62-7f07-1e9c-e053-3a05fe0a45ef
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1
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Introduzione alla chimica farmaceutica, file dd9e0c62-806c-1e9c-e053-3a05fe0a45ef
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1
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Ebola therapy: Developing new drugs or repurposing old ones?, file dd9e0c62-8465-1e9c-e053-3a05fe0a45ef
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1
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Molecular dissection of lubeluzole use-dependent block of voltage-gated sodium channels discloses new therapeutic potentials, file dd9e0c62-a9c1-1e9c-e053-3a05fe0a45ef
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1
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Chiral aryloxyalkylamines: selective 5-HT1B/1D activation and analgesic activity, file dd9e0c63-01d6-1e9c-e053-3a05fe0a45ef
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1
|
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Did ebola survivors use plant medicines, and if so, which ones?, file dd9e0c64-1a1d-1e9c-e053-3a05fe0a45ef
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1
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Dotazione familiare di farmaci e presidi sanitari nella cittadina di Mottola, file dd9e0c64-21de-1e9c-e053-3a05fe0a45ef
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1
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Plotting intersections, file dd9e0c64-249d-1e9c-e053-3a05fe0a45ef
|
1
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The trivial names of citrus limonoids, file dd9e0c64-254b-1e9c-e053-3a05fe0a45ef
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1
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An improved synthesis of m-hydroxymexiletine, a potent mexiletine metabolite, file dd9e0c64-2a7b-1e9c-e053-3a05fe0a45ef
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1
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Synthesis and in vitro sodium channel blocking activity evaluation of novel homochiral mexiletine analogs, file dd9e0c64-b5a7-1e9c-e053-3a05fe0a45ef
|
1
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Positional isomers of mannose-quinoline conjugates and their copper complexes: Exploring the biological activity, file dd9e0c65-8a53-1e9c-e053-3a05fe0a45ef
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1
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Comment on "in Situ Derivatization of (RS)-Mexiletine and Enantioseparation Using Micellar Liquid Chromatography: A Green Approach", file dd9e0c66-59a5-1e9c-e053-3a05fe0a45ef
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1
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The therapeutic power of green, file dd9e0c67-4c75-1e9c-e053-3a05fe0a45ef
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1
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Facile routes for the preparation of 3,4-disubstituted 1,3-oxazolidines and 1,2,5-trisubstituted imidazolidin-4-ones, file dd9e0c67-c2b5-1e9c-e053-3a05fe0a45ef
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1
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Facile entry to (-)-R- and (+)-(S)-mexiletine, file dd9e0c67-c643-1e9c-e053-3a05fe0a45ef
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1
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Design, synthesis, and pharmacological effects of structurally simple ligands for MT1 and MT2 melatonin receptors, file dd9e0c67-c9c1-1e9c-e053-3a05fe0a45ef
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1
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Facile Entry to Ethyl Tetrahydro-1H-pyrrolizin-7a(5H)-ylacetate: a Versatile Pharmaceutical Intermediate, file dd9e0c67-f512-1e9c-e053-3a05fe0a45ef
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1
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Stereospecific synthesis of mexiletine and related compounds: Mitsunobu versus Williamson reaction, file dd9e0c68-0b25-1e9c-e053-3a05fe0a45ef
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1
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Ultrasound and deep eutectic solvents: An efficient combination to tune the mechanism of steviol glycosides extraction, file dd9e0c68-c764-1e9c-e053-3a05fe0a45ef
|
1
|
| Totale |
1.916 |