IRIS
LACIVITA, ENZA
 Distribuzione geografica
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Continente #
NA - Nord America 5.584
EU - Europa 1.447
AS - Asia 1.177
SA - Sud America 348
AF - Africa 20
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 8.583
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Nazione #
US - Stati Uniti d'America 5.545
CN - Cina 414
SE - Svezia 342
BR - Brasile 324
SG - Singapore 308
HK - Hong Kong 302
RU - Federazione Russa 224
DE - Germania 204
IT - Italia 188
UA - Ucraina 120
GB - Regno Unito 118
FI - Finlandia 114
ID - Indonesia 36
IN - India 34
FR - Francia 28
BE - Belgio 25
VN - Vietnam 25
IE - Irlanda 24
CA - Canada 20
AT - Austria 13
ES - Italia 13
MX - Messico 12
NL - Olanda 12
JP - Giappone 11
AR - Argentina 7
PL - Polonia 7
ZA - Sudafrica 7
BD - Bangladesh 6
CO - Colombia 6
PK - Pakistan 6
TR - Turchia 6
AU - Australia 5
IR - Iran 5
UZ - Uzbekistan 5
AL - Albania 4
EC - Ecuador 4
IQ - Iraq 4
EG - Egitto 3
JM - Giamaica 3
KE - Kenya 3
MA - Marocco 3
PY - Paraguay 3
RO - Romania 3
VE - Venezuela 3
AE - Emirati Arabi Uniti 2
DM - Dominica 2
EU - Europa 2
KR - Corea 2
LT - Lituania 2
OM - Oman 2
SA - Arabia Saudita 2
SK - Slovacchia (Repubblica Slovacca) 2
TN - Tunisia 2
AZ - Azerbaigian 1
BG - Bulgaria 1
BN - Brunei Darussalam 1
CL - Cile 1
DZ - Algeria 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
KG - Kirghizistan 1
KW - Kuwait 1
KZ - Kazakistan 1
NO - Norvegia 1
PS - Palestinian Territory 1
TT - Trinidad e Tobago 1
Totale 8.583
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Città #
Fairfield 874
Woodbridge 565
Houston 395
Ashburn 383
Chandler 378
Seattle 371
Cambridge 316
Ann Arbor 312
Hong Kong 300
Wilmington 292
Jacksonville 279
Nyköping 257
Singapore 203
Roxbury 114
Lawrence 104
Bari 101
Beijing 98
Nanjing 97
Boardman 79
New York 75
Princeton 68
Des Moines 64
Inglewood 55
San Diego 39
Brooklyn 38
Jakarta 36
Rome 31
Shenyang 28
Santa Clara 27
Dong Ket 25
Dublin 25
Los Angeles 25
Brussels 23
London 23
Jiaxing 22
Nanchang 21
Pune 21
Hebei 20
Frankfurt am Main 19
Nuremberg 19
Unterföhring 17
Changsha 16
Helsinki 16
Paris 16
São Paulo 16
Norwalk 14
Council Bluffs 13
Tianjin 13
Turku 13
The Dalles 12
Dearborn 11
Falls Church 11
Rio de Janeiro 11
North Bergen 10
Shanghai 10
Indiana 8
Santiago de Compostela 8
Toronto 8
Belo Horizonte 7
Moscow 7
Redwood City 7
San Francisco 7
Naples 6
Warsaw 6
Chicago 5
Curitiba 5
Goiânia 5
Munich 5
Phoenix 5
Taizhou 5
Tashkent 5
Vienna 5
Acquaviva delle Fonti 4
Betim 4
Brasília 4
Campo Grande 4
Chiswick 4
Cuiabá 4
Düsseldorf 4
Guangzhou 4
Johannesburg 4
Ottawa 4
Tirana 4
Tokyo 4
Volta Redonda 4
Wuxi 4
Ardabil 3
Caracas 3
Charlotte 3
Conceição do Coité 3
Falkenstein 3
Franca 3
Hortolândia 3
Kansas City 3
Kingston 3
Kyoto 3
Leawood 3
Mexico City 3
Milan 3
Montreal 3
Totale 6.623
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Nome #
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 151
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 148
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 147
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 139
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 132
5-HT7 receptor activation: procognitive and antiamnesic effects 132
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 132
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 126
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 125
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 120
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 115
5 HT1A receptor, an old target for new therapeutic agents 114
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 114
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 114
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 113
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 112
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 110
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 110
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 110
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 109
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 108
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 104
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 103
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 102
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 102
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 101
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 101
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 100
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 99
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 94
Activatable fluorescent probes: a new concept in optical molecular imaging 94
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 94
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 92
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 92
The therapeutic potential of 5-HT1A receptors: a patent review. 91
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 90
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 90
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 89
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 89
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 88
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 87
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 87
Structural insights into serotonin receptor ligands polypharmacology 86
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 85
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 85
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 83
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 82
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 82
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 82
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 81
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 81
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 79
The medicinal chemistry of 5-HT2C receptor ligands 79
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 79
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 78
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 77
Developments in fluorescent probes for receptor research 76
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 75
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 74
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 71
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 70
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 70
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 68
null 68
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 67
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 66
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 66
Selective Agents for Serotonin2C (5-HT2C) Receptor 65
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 64
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 64
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogs of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines 63
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation 62
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 62
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 61
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 60
N-[omega-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands 58
Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome. 57
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 56
PREVENTION AND TREATMENT OF RETT SYNDROME 55
Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface. 54
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides as 5-HT7 receptor agents 54
Development of a PET radioligand for the 5-HT7 receptor. Preliminary characterization using autoradiography 52
The GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved? 52
Design, synthesis, radiolabeling and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential Positron Emission Tomography tracer for the dopamine D4 receptors 51
Design, synthesis, radiolabeling and in vivo biological evaluation of potential 5-Ht7 receptor PET tracers: Structural modifications of the selective agonist Lp-211 50
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 49
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 49
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 48
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 receptor ligands 45
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. 45
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 44
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 43
Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism 42
THE ARYLPIPERAZINE DERIVATIVES LP-211 AND MEL-9 ARE INACTIVATING ANTAGONISTS AT HUMAN SEROTONIN 5-HT7 RECEPTORS 42
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III 42
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2 42
Fluorescent probes: from bench to bedside 41
Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter(SERT)and 5-HT1A receptors 41
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 41
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 39
Totale 8.173
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Categoria #
all - tutte 39.445
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 39.445
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020105 0 0 0 0 0 0 0 0 0 0 0 105
2020/20211.104 88 93 63 74 102 53 135 91 79 161 81 84
2021/2022900 51 115 29 34 41 67 46 49 84 47 150 187
2022/20231.134 203 94 77 89 154 146 16 130 172 4 25 24
2023/2024415 28 76 26 12 31 99 13 14 26 17 19 54
2024/20251.988 62 11 188 74 59 147 201 177 110 100 330 529
Totale 8.934