IRIS
LACIVITA, ENZA
 Distribuzione geografica
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Continente #
NA - Nord America 8.932
AS - Asia 3.013
EU - Europa 2.827
SA - Sud America 819
Continente sconosciuto - Info sul continente non disponibili 394
AF - Africa 109
OC - Oceania 7
Totale 16.101
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Nazione #
US - Stati Uniti d'America 8.630
SG - Singapore 1.226
IT - Italia 925
CN - Cina 671
BR - Brasile 641
HK - Hong Kong 382
SE - Svezia 344
RU - Federazione Russa 258
DE - Germania 244
VN - Vietnam 227
FI - Finlandia 184
GB - Regno Unito 162
LT - Lituania 159
FR - Francia 154
CA - Canada 133
UA - Ucraina 128
IN - India 99
BD - Bangladesh 82
AR - Argentina 71
ID - Indonesia 59
MX - Messico 49
AT - Austria 45
NL - Olanda 40
IQ - Iraq 38
ES - Italia 33
PL - Polonia 31
JP - Giappone 29
BE - Belgio 27
PK - Pakistan 27
IE - Irlanda 26
CO - Colombia 25
EC - Ecuador 25
NO - Norvegia 25
TR - Turchia 25
VE - Venezuela 25
ZA - Sudafrica 23
SA - Arabia Saudita 21
CR - Costa Rica 19
UZ - Uzbekistan 16
JM - Giamaica 15
TT - Trinidad e Tobago 15
MY - Malesia 14
HN - Honduras 13
SV - El Salvador 13
TN - Tunisia 13
CL - Cile 12
GT - Guatemala 12
MA - Marocco 12
PH - Filippine 12
CW - ???statistics.table.value.countryCode.CW??? 11
IL - Israele 11
KE - Kenya 11
PR - Porto Rico 10
EG - Egitto 9
PY - Paraguay 9
AL - Albania 8
JO - Giordania 8
KZ - Kazakistan 8
DZ - Algeria 7
NI - Nicaragua 7
SC - Seychelles 7
AU - Australia 6
IR - Iran 6
KR - Corea 6
NG - Nigeria 6
OM - Oman 6
AE - Emirati Arabi Uniti 5
AZ - Azerbaigian 5
CI - Costa d'Avorio 5
ET - Etiopia 5
SY - Repubblica araba siriana 5
BO - Bolivia 4
CZ - Repubblica Ceca 4
KG - Kirghizistan 4
LB - Libano 4
PA - Panama 4
PT - Portogallo 4
RO - Romania 4
RS - Serbia 4
SN - Senegal 4
BB - Barbados 3
CH - Svizzera 3
DM - Dominica 3
GE - Georgia 3
GP - Guadalupe 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
BG - Bulgaria 2
CY - Cipro 2
DK - Danimarca 2
EU - Europa 2
GR - Grecia 2
GY - Guiana 2
HU - Ungheria 2
MD - Moldavia 2
NP - Nepal 2
PS - Palestinian Territory 2
TH - Thailandia 2
TW - Taiwan 2
UY - Uruguay 2
Totale 15.703
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Città #
Fairfield 875
Ashburn 854
Singapore 634
San Jose 576
Woodbridge 566
Houston 407
Seattle 376
Chandler 373
Hong Kong 370
Cambridge 317
Ann Arbor 312
Milan 305
Wilmington 295
Dallas 285
Jacksonville 285
Nyköping 248
Beijing 203
Council Bluffs 199
Vilnius 153
New York 127
Bari 121
Los Angeles 121
Rome 118
Boardman 114
Roxbury 114
Lauterbourg 112
Nanjing 99
Lawrence 97
Santa Clara 96
Helsinki 86
Ho Chi Minh City 78
Des Moines 68
Princeton 68
Brooklyn 58
Inglewood 55
São Paulo 55
Washington 48
San Diego 41
Hanoi 39
Jakarta 39
Buffalo 38
Columbus 35
North Bergen 33
London 32
Figino 31
Montreal 31
San Francisco 31
Chicago 30
Toronto 29
Dublin 28
Shenyang 28
Warsaw 28
Denver 26
Rio de Janeiro 26
Vienna 26
Dong Ket 25
Brussels 24
Frankfurt am Main 24
Jiaxing 22
Phoenix 22
Pune 22
Nanchang 21
Naples 21
Bjørkelangen 20
Hebei 20
Munich 20
Nuremberg 19
The Dalles 19
Atlanta 18
Orem 18
Baghdad 17
Changsha 17
Paris 17
Turin 17
Unterföhring 17
Tokyo 16
Tashkent 15
Tianjin 15
Falkenstein 14
Mexico City 14
Norwalk 14
Curitiba 13
Shanghai 13
Stockholm 13
Turku 13
Brasília 12
Kingston 12
Belo Horizonte 11
Boston 11
Dearborn 11
Falls Church 11
Guayaquil 11
Johannesburg 11
San José 11
Bologna 10
Nairobi 10
San Salvador 10
Buenos Aires 9
Dhaka 9
Fortaleza 9
Totale 10.537
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Nome #
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 465
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 307
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 294
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 235
5-HT7 receptor activation: procognitive and antiamnesic effects 216
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 202
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 201
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 198
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 197
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 196
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 189
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 187
5 HT1A receptor, an old target for new therapeutic agents 186
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 185
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 182
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 182
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 181
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 180
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 175
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 173
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 161
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 161
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 160
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 157
Activatable fluorescent probes: a new concept in optical molecular imaging 155
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 155
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 153
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 152
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 151
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 150
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 148
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 144
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 138
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 136
Structural insights into serotonin receptor ligands polypharmacology 134
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 133
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 132
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 131
FPR2 and brimstone: a novel approach for the treatment of neuroinflammation 130
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 129
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 128
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 126
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 126
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 126
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 125
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 125
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 124
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 124
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 124
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 124
The therapeutic potential of 5-HT1A receptors: a patent review. 123
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 123
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 122
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 122
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 120
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 119
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 118
5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn 117
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 117
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 117
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 116
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 115
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 115
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 114
The GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved? 114
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 113
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 112
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 111
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation 110
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogs of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines 109
Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey 108
The medicinal chemistry of 5-HT2C receptor ligands 108
The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease 107
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 107
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 106
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 106
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 106
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges 105
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 104
Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface. 104
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 103
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 103
The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology 103
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 100
Developments in fluorescent probes for receptor research 98
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 98
Selective Agents for Serotonin2C (5-HT2C) Receptor 95
Development of a PET radioligand for the 5-HT7 receptor. Preliminary characterization using autoradiography 93
N-[omega-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands 92
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 91
Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome. 90
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 89
Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures 88
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 87
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 87
FIGHTING CHRONIC NEUROINFLAMMATION WITH NOVEL P2X7 RECEPTOR ANTAGONISTS: AN INTRIGUING THERAPEUTIC APPROACH TO THE NEURODEGENERATIVE DISEASES 86
Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models 85
Selective serotonergic 5-HT7 receptor agonists as a new therapeutic venue for treatment of cognitive disorders: focus on Fragile X syndrome. 85
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides as 5-HT7 receptor agents 85
PREVENTION AND TREATMENT OF RETT SYNDROME 82
Totale 13.721
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Categoria #
all - tutte 63.007
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 63.007
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022671 0 0 0 0 41 67 46 49 84 47 150 187
2022/20231.106 195 91 75 88 153 142 16 126 167 4 25 24
2023/2024400 28 74 26 11 29 96 12 11 26 16 19 52
2024/20252.041 61 11 186 70 58 146 196 176 108 97 321 611
2025/20265.020 639 297 458 530 388 236 580 186 464 451 206 585
2026/20272.137 153 446 469 907 162 0 0 0 0 0 0 0
Totale 16.101