IRIS
LACIVITA, ENZA
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 5.407
EU - Europa 1.384
AS - Asia 777
SA - Sud America 158
AF - Africa 6
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 2
Totale 7.739
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 5.386
CN - Cina 396
SE - Svezia 340
SG - Singapore 242
RU - Federazione Russa 222
DE - Germania 193
IT - Italia 186
BR - Brasile 144
UA - Ucraina 119
GB - Regno Unito 107
FI - Finlandia 101
ID - Indonesia 36
IN - India 27
BE - Belgio 25
FR - Francia 25
VN - Vietnam 25
IE - Irlanda 23
HK - Hong Kong 19
CA - Canada 15
AT - Austria 12
NL - Olanda 11
ES - Italia 8
JP - Giappone 8
AR - Argentina 5
AU - Australia 5
IR - Iran 5
MX - Messico 4
UZ - Uzbekistan 4
CO - Colombia 3
EC - Ecuador 3
MA - Marocco 3
PK - Pakistan 3
RO - Romania 3
TR - Turchia 3
AL - Albania 2
DM - Dominica 2
EG - Egitto 2
EU - Europa 2
KR - Corea 2
SK - Slovacchia (Repubblica Slovacca) 2
AE - Emirati Arabi Uniti 1
AZ - Azerbaigian 1
BG - Bulgaria 1
CL - Cile 1
EE - Estonia 1
GE - Georgia 1
GR - Grecia 1
IQ - Iraq 1
KE - Kenya 1
KG - Kirghizistan 1
KW - Kuwait 1
KZ - Kazakistan 1
LT - Lituania 1
NO - Norvegia 1
PY - Paraguay 1
VE - Venezuela 1
Totale 7.739
Salva come PNG Salva come JPEG
Città #
Fairfield 874
Woodbridge 565
Houston 393
Chandler 378
Ashburn 372
Seattle 370
Cambridge 316
Ann Arbor 312
Wilmington 292
Jacksonville 279
Nyköping 257
Singapore 138
Roxbury 114
Lawrence 104
Bari 101
Nanjing 97
Beijing 83
Boardman 79
Princeton 68
New York 66
Des Moines 64
Inglewood 55
San Diego 39
Jakarta 36
Brooklyn 32
Rome 30
Shenyang 28
Dong Ket 25
Brussels 23
Dublin 23
Jiaxing 22
Nanchang 21
Hebei 20
London 20
Pune 20
Santa Clara 19
Hong Kong 17
Unterföhring 17
Changsha 16
Frankfurt am Main 16
Helsinki 16
Los Angeles 16
Nuremberg 16
Paris 16
Norwalk 14
Council Bluffs 13
Tianjin 13
Dearborn 11
Falls Church 11
North Bergen 10
Shanghai 10
Indiana 8
Santiago de Compostela 8
Toronto 8
Redwood City 7
São Paulo 7
Moscow 6
Naples 6
Belo Horizonte 5
Taizhou 5
Acquaviva delle Fonti 4
Chiswick 4
Curitiba 4
Düsseldorf 4
Guangzhou 4
Ottawa 4
Rio de Janeiro 4
Tashkent 4
Vienna 4
Wuxi 4
Ardabil 3
Falkenstein 3
Kansas City 3
Kyoto 3
Leawood 3
Milan 3
New Bedfont 3
San Francisco 3
San Pedro 3
Tappahannock 3
Wandsworth 3
Wuhan 3
Acton 2
Augusta 2
Bitonto 2
Boydton 2
Campina Grande 2
Campo Grande 2
Casablanca 2
Central 2
Clifton 2
Dalian 2
Ercolano 2
Ferrara 2
Fortaleza 2
Goiânia 2
Gravataí 2
Guayaquil 2
Hangzhou 2
Hanover 2
Totale 6.119
Salva come PNG Salva come JPEG
Nome #
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 144
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 139
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 139
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 133
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 125
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 124
5-HT7 receptor activation: procognitive and antiamnesic effects 124
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 120
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 115
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 113
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 110
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 110
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 107
5 HT1A receptor, an old target for new therapeutic agents 107
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 106
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 106
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 105
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 105
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 104
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 104
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 100
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 99
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 97
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 96
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 96
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 93
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 92
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 91
Activatable fluorescent probes: a new concept in optical molecular imaging 90
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 90
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 88
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 87
The therapeutic potential of 5-HT1A receptors: a patent review. 85
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 85
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 84
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 84
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 83
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 83
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 82
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 82
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 82
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 82
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 81
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 79
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 78
Structural insights into serotonin receptor ligands polypharmacology 77
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 77
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 76
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 76
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 76
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 75
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 73
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 73
The medicinal chemistry of 5-HT2C receptor ligands 72
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 70
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 69
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 69
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 69
null 68
Developments in fluorescent probes for receptor research 68
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 66
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 66
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 62
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 60
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 60
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogs of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines 60
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 58
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation 57
Selective Agents for Serotonin2C (5-HT2C) Receptor 57
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 57
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 57
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 56
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 55
N-[omega-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands 52
Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface. 52
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 52
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 51
Development of a PET radioligand for the 5-HT7 receptor. Preliminary characterization using autoradiography 49
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 49
Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome. 49
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides as 5-HT7 receptor agents 48
PREVENTION AND TREATMENT OF RETT SYNDROME 47
The GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved? 47
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 46
Design, synthesis, radiolabeling and in vivo biological evaluation of potential 5-Ht7 receptor PET tracers: Structural modifications of the selective agonist Lp-211 46
Design, synthesis, radiolabeling and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential Positron Emission Tomography tracer for the dopamine D4 receptors 44
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 42
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 41
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 receptor ligands 40
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. 40
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 37
Fluorescent probes: from bench to bedside 36
Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter(SERT)and 5-HT1A receptors 36
Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism 35
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 34
THE ARYLPIPERAZINE DERIVATIVES LP-211 AND MEL-9 ARE INACTIVATING ANTAGONISTS AT HUMAN SEROTONIN 5-HT7 RECEPTORS 34
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III 34
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2 34
The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology 34
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 29
Totale 7.526
Salva come PNG Salva come JPEG
Categoria #
all - tutte 37.378
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.378
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020251 0 0 0 0 0 0 0 0 0 0 146 105
2020/20211.104 88 93 63 74 102 53 135 91 79 161 81 84
2021/2022900 51 115 29 34 41 67 46 49 84 47 150 187
2022/20231.134 203 94 77 89 154 146 16 130 172 4 25 24
2023/2024415 28 76 26 12 31 99 13 14 26 17 19 54
2024/20251.144 62 11 188 74 59 147 201 177 110 100 15 0
Totale 8.090