IRIS
LACIVITA, ENZA
 Distribuzione geografica
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Continente #
NA - Nord America 7.179
AS - Asia 2.936
EU - Europa 2.001
SA - Sud America 790
AF - Africa 103
OC - Oceania 7
Continente sconosciuto - Info sul continente non disponibili 3
Totale 13.019
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Nazione #
US - Stati Uniti d'America 7.045
SG - Singapore 1.218
CN - Cina 660
BR - Brasile 624
HK - Hong Kong 374
SE - Svezia 343
IT - Italia 315
DE - Germania 242
RU - Federazione Russa 237
VN - Vietnam 227
FI - Finlandia 184
FR - Francia 152
GB - Regno Unito 146
UA - Ucraina 128
IN - India 98
AR - Argentina 69
CA - Canada 61
BD - Bangladesh 58
ID - Indonesia 57
AT - Austria 45
MX - Messico 45
IQ - Iraq 38
NL - Olanda 38
JP - Giappone 28
ES - Italia 27
BE - Belgio 26
IE - Irlanda 26
PK - Pakistan 26
NO - Norvegia 25
EC - Ecuador 24
TR - Turchia 24
PL - Polonia 23
ZA - Sudafrica 23
CO - Colombia 22
VE - Venezuela 21
SA - Arabia Saudita 16
UZ - Uzbekistan 16
TN - Tunisia 13
MA - Marocco 12
MY - Malesia 12
CL - Cile 11
KE - Kenya 11
PH - Filippine 11
EG - Egitto 9
PY - Paraguay 9
JO - Giordania 8
LT - Lituania 8
AL - Albania 7
CR - Costa Rica 7
DZ - Algeria 7
JM - Giamaica 7
KZ - Kazakistan 7
AU - Australia 6
IR - Iran 6
KR - Corea 6
NG - Nigeria 6
OM - Oman 6
AE - Emirati Arabi Uniti 5
AZ - Azerbaigian 5
CI - Costa d'Avorio 5
ET - Etiopia 5
SY - Repubblica araba siriana 5
BO - Bolivia 4
KG - Kirghizistan 4
LB - Libano 4
PT - Portogallo 4
RS - Serbia 4
SN - Senegal 4
CH - Svizzera 3
CZ - Repubblica Ceca 3
GE - Georgia 3
HN - Honduras 3
PA - Panama 3
RO - Romania 3
SK - Slovacchia (Repubblica Slovacca) 3
CY - Cipro 2
DM - Dominica 2
EU - Europa 2
GR - Grecia 2
GY - Guiana 2
HU - Ungheria 2
MD - Moldavia 2
NP - Nepal 2
PE - Perù 2
PS - Palestinian Territory 2
TH - Thailandia 2
TT - Trinidad e Tobago 2
TW - Taiwan 2
UY - Uruguay 2
AO - Angola 1
BB - Barbados 1
BG - Bulgaria 1
BJ - Benin 1
BN - Brunei Darussalam 1
BW - Botswana 1
CG - Congo 1
EE - Estonia 1
GD - Grenada 1
GI - Gibilterra 1
GT - Guatemala 1
Totale 13.009
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Città #
Fairfield 874
Ashburn 659
Singapore 628
Woodbridge 566
Houston 398
Seattle 374
Chandler 373
Hong Kong 366
San Jose 359
Cambridge 317
Ann Arbor 312
Wilmington 292
Jacksonville 281
Nyköping 248
Dallas 236
Beijing 199
Bari 118
Roxbury 114
Lauterbourg 112
Nanjing 99
Lawrence 97
New York 94
Helsinki 86
Boardman 79
Ho Chi Minh City 78
Council Bluffs 76
Los Angeles 72
Princeton 68
Des Moines 66
Inglewood 55
Santa Clara 52
Brooklyn 51
São Paulo 44
San Diego 41
Hanoi 39
Jakarta 39
Buffalo 33
Rome 33
London 29
Shenyang 28
Dublin 27
Vienna 26
Dong Ket 25
Rio de Janeiro 24
Brussels 23
Chicago 23
Frankfurt am Main 23
Jiaxing 22
Pune 22
Warsaw 22
Nanchang 21
Bjørkelangen 20
Hebei 20
Munich 20
Nuremberg 19
Baghdad 17
Changsha 17
Paris 17
Unterföhring 17
Montreal 16
Tashkent 15
Tianjin 15
Tokyo 15
Falkenstein 14
Norwalk 14
The Dalles 14
Curitiba 13
Phoenix 13
San Francisco 13
Turku 13
Columbus 12
Mexico City 12
Shanghai 12
Stockholm 12
Belo Horizonte 11
Brasília 11
Dearborn 11
Denver 11
Falls Church 11
Guayaquil 11
Johannesburg 11
Milan 11
Orem 11
Toronto 11
Nairobi 10
North Bergen 10
Atlanta 9
Boston 9
Dhaka 9
Goiânia 9
Santiago de Compostela 9
Vancouver 9
Amman 8
Fortaleza 8
Haiphong 8
Indiana 8
Istanbul 8
Moscow 8
Naples 8
Redwood City 8
Totale 8.941
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Nome #
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 230
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 206
5-HT7 receptor activation: procognitive and antiamnesic effects 200
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 190
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 185
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 181
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 179
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 177
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 174
5 HT1A receptor, an old target for new therapeutic agents 172
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 170
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 166
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 163
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 162
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 161
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 159
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 157
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 148
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 147
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 147
Activatable fluorescent probes: a new concept in optical molecular imaging 145
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 143
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 141
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 140
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 139
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 136
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 136
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 136
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 136
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 128
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 126
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 124
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 122
Structural insights into serotonin receptor ligands polypharmacology 120
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 120
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 117
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 117
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 116
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 116
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 116
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 115
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 114
The therapeutic potential of 5-HT1A receptors: a patent review. 114
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 112
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 112
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 111
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 111
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 111
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 111
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 111
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 110
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 107
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 106
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 106
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 105
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 105
The medicinal chemistry of 5-HT2C receptor ligands 103
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 103
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 103
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 103
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 102
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 102
FPR2 and brimstone: a novel approach for the treatment of neuroinflammation 101
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 101
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 96
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 96
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 94
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 94
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation 93
Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface. 92
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 92
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogs of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines 91
Developments in fluorescent probes for receptor research 91
The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology 91
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders 91
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 90
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 90
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 89
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 89
The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease 88
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 87
The GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved? 86
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges 85
5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn 85
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 84
Selective Agents for Serotonin2C (5-HT2C) Receptor 79
N-[omega-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands 78
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides as 5-HT7 receptor agents 78
Development of a PET radioligand for the 5-HT7 receptor. Preliminary characterization using autoradiography 77
Design and Synthesis of Arylpiperazine Serotonergic/ Dopaminergic Ligands with Neuroprotective Properties 77
PREVENTION AND TREATMENT OF RETT SYNDROME 76
Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome. 76
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 74
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. 73
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 72
Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures 71
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 71
Design, synthesis, radiolabeling and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential Positron Emission Tomography tracer for the dopamine D4 receptors 71
Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models 70
Multitarget-Directed Ligands Hitting Serotonin Receptors: A Medicinal Chemistry Survey 70
Totale 11.634
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Categoria #
all - tutte 54.098
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 54.098
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/202184 0 0 0 0 0 0 0 0 0 0 0 84
2021/2022900 51 115 29 34 41 67 46 49 84 47 150 187
2022/20231.106 195 91 75 88 153 142 16 126 167 4 25 24
2023/2024400 28 74 26 11 29 96 12 11 26 16 19 52
2024/20252.041 61 11 186 70 58 146 196 176 108 97 321 611
2025/20264.450 639 297 458 530 388 236 580 186 464 451 206 15
Totale 13.394