IRIS
LACIVITA, ENZA
 Distribuzione geografica
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Continente #
NA - Nord America 5.370
EU - Europa 1.055
AS - Asia 478
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 2
SA - Sud America 1
Totale 6.910
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Nazione #
US - Stati Uniti d'America 5.365
CN - Cina 389
SE - Svezia 362
DE - Germania 163
IT - Italia 133
UA - Ucraina 118
GB - Regno Unito 99
FI - Finlandia 92
VN - Vietnam 25
IN - India 24
FR - Francia 22
IE - Irlanda 21
SG - Singapore 20
BE - Belgio 19
RU - Federazione Russa 14
HK - Hong Kong 7
IR - Iran 5
JP - Giappone 5
AU - Australia 4
CA - Canada 3
RO - Romania 3
DM - Dominica 2
EU - Europa 2
NL - Olanda 2
PL - Polonia 2
TR - Turchia 2
AT - Austria 1
BG - Bulgaria 1
CL - Cile 1
CZ - Repubblica Ceca 1
GR - Grecia 1
KZ - Kazakistan 1
SK - Slovacchia (Repubblica Slovacca) 1
Totale 6.910
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Città #
Fairfield 874
Woodbridge 565
Chandler 415
Houston 393
Ashburn 375
Seattle 369
Cambridge 314
Ann Arbor 312
Wilmington 292
Jacksonville 279
Nyköping 279
Roxbury 114
Lawrence 111
Nanjing 97
Bari 94
Beijing 83
New York 80
Boardman 77
Princeton 68
Des Moines 64
Inglewood 55
San Diego 39
Brooklyn 32
Shenyang 27
Dong Ket 25
Jiaxing 22
Dublin 21
Nanchang 21
Hebei 20
Pune 20
London 19
Brussels 17
Paris 17
Unterföhring 17
Changsha 16
Singapore 15
Los Angeles 14
Norwalk 14
Tianjin 13
Dearborn 11
Falls Church 11
Frankfurt am Main 10
Indiana 8
Shanghai 8
Guangzhou 7
Helsinki 7
Redwood City 7
Hong Kong 6
Taizhou 5
Wuxi 5
Acquaviva delle Fonti 4
Chiswick 4
Naples 4
Ardabil 3
Ercolano 3
Kansas City 3
Leawood 3
New Bedfont 3
Rome 3
San Francisco 3
Tappahannock 3
Washington 3
Wuhan 3
Acton 2
Augusta 2
Bitonto 2
Boydton 2
Bąków 2
Clifton 2
Dalian 2
Ferrara 2
Fuzhou 2
Hangzhou 2
Hanover 2
Hefei 2
Islington 2
Istanbul 2
Jinan 2
Jinhua 2
Munich 2
Ningbo 2
Patna 2
Qingdao 2
Roseau 2
Toronto 2
Waanrode 2
West Jordan 2
Adelfia 1
Almaty 1
Auburn Hills 1
Bratislava 1
Brisbane 1
Brno 1
Bucharest 1
Castellammare Di Stabia 1
Central 1
Centrale 1
Chizhou 1
Dongyang 1
Fort Myers 1
Totale 5.867
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Nome #
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 133
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 133
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 131
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 126
5-HT7 receptor activation: procognitive and antiamnesic effects 113
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 111
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 111
Novel Derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Improved Fluorescent and σ Receptors Binding Properties 105
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 105
Analogues of σ Receptor Ligand 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with Added Polar Functionality and Reduced Lipophilicity for Potential Use as Positron Emission Tomography Radiotracers 104
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 102
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 98
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 97
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 97
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 97
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 97
5 HT1A receptor, an old target for new therapeutic agents 96
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 95
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 94
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 93
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 92
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 91
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 90
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 89
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 89
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 86
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 83
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 83
The therapeutic potential of 5-HT1A receptors: a patent review. 82
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 82
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 81
Activatable fluorescent probes: a new concept in optical molecular imaging 81
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 80
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 79
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 78
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 78
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 76
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 76
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 75
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 75
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 75
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 74
Structural insights into serotonin receptor ligands polypharmacology 74
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 74
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 72
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 72
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 70
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 70
null 68
The medicinal chemistry of 5-HT2C receptor ligands 67
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 66
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 65
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 65
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 65
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 64
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 64
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 64
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 64
Developments in fluorescent probes for receptor research 63
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 62
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 60
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 57
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 55
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 54
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 52
trans-4-[4-(Methoxyphenyl)cyclohexyl]-1-arylpiperazines: a new class of potent and selective 5-HT1A receptor ligands as conformationally constrained analogs of 4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]-1-arylpiperazines 52
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 52
Selective Agents for Serotonin2C (5-HT2C) Receptor 49
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 48
N-[omega-[4-(2-Methoxyphenyl)-1-piperazinyl]alkyl]-2-quinolinamines as High-Affinity Fluorescent 5-HT1A Receptor Ligands 47
Development of a PET radioligand for the 5-HT7 receptor. Preliminary characterization using autoradiography 47
Radiosynthesis and in vivo Evaluation of Carbon-11 (2S)-3-(1H-Indol-3-yl)-2-[(4-methoxyphenyl)carbamoyl]amino-N-[1-(5-methoxypyridin-2-yl)cyclohexyl]methylpropanamide: An Attempt to Visualize Brain Formyl Peptide Receptors in Mouse Models of Neuroinflammation 47
Prepuberal Stimulation of 5-HT7-R by LP-211 in a Rat Model of Hyper-Activity and Attention-Deficit: Permanent Effects on Attention, Brain Amino Acids and Synaptic Markers in the Fronto-Striatal Interface. 47
PREVENTION AND TREATMENT OF RETT SYNDROME 45
Design and synthesis of arylpiperazine-based fluorescent ligands for serotonin 5-HT1A and dopamine D3 receptors. 45
Pharmacological Stimulation of the Brain Serotonin Receptor 7 as a Novel Therapeutic Approach for Rett Syndrome. 44
First structure–activity relationship study on dopamine D3 receptor agents with N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamide structure 42
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 42
The GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved? 41
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 41
Design synthesis, and binding affinity of potential positron emission tomography (PET) ligands for visualitation of brain dopamine D3 receptors 40
Design, synthesis, radiolabeling and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential Positron Emission Tomography tracer for the dopamine D4 receptors 40
Design, synthesis, radiolabeling and in vivo biological evaluation of potential 5-Ht7 receptor PET tracers: Structural modifications of the selective agonist Lp-211 39
null 39
Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 receptor ligands 37
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides as 5-HT7 receptor agents 37
Recent advances in the field of 5-HT7 receptor agents with 1-arylpiperazine structure. 35
N-[4-(4-Arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 ligands 35
Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats. 34
Fluorescent probes: from bench to bedside 33
Design and synthesis of long-chain arylpiperazines with mixed affinity for serotonin transporter(SERT)and 5-HT1A receptors 31
THE ARYLPIPERAZINE DERIVATIVES LP-211 AND MEL-9 ARE INACTIVATING ANTAGONISTS AT HUMAN SEROTONIN 5-HT7 RECEPTORS 30
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2 29
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 28
Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III 28
The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease 27
Selective serotonergic 5-HT7 receptor agonists as a new therapeutic venue for treatment of cognitive disorders: focus on Fragile X syndrome. 27
The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology 27
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 25
Totale 6.802
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Categoria #
all - tutte 31.422
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 31.422
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.707 0 99 79 181 222 122 180 184 235 154 146 105
2020/20211.104 88 93 63 74 102 53 135 91 79 161 81 84
2021/2022900 51 115 29 34 41 67 46 49 84 47 150 187
2022/20231.227 214 107 84 92 163 160 17 145 188 4 27 26
2023/2024457 30 82 27 15 35 115 13 17 26 17 19 61
2024/202579 69 10 0 0 0 0 0 0 0 0 0 0
Totale 7.160