IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 7.856
EU - Europa 1.783
AS - Asia 917
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 2
Totale 10.568
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Nazione #
US - Stati Uniti d'America 7.848
CN - Cina 645
SE - Svezia 600
IT - Italia 293
DE - Germania 264
UA - Ucraina 192
VN - Vietnam 157
GB - Regno Unito 151
FI - Finlandia 140
SG - Singapore 52
FR - Francia 45
IE - Irlanda 33
IN - India 29
BE - Belgio 24
RU - Federazione Russa 19
IR - Iran 14
HK - Hong Kong 7
AU - Australia 6
CA - Canada 5
CZ - Repubblica Ceca 5
JP - Giappone 5
PL - Polonia 5
EU - Europa 4
TR - Turchia 3
AT - Austria 2
CL - Cile 2
DM - Dominica 2
ID - Indonesia 2
NL - Olanda 2
RO - Romania 2
BG - Bulgaria 1
CH - Svizzera 1
ES - Italia 1
GR - Grecia 1
IL - Israele 1
KR - Corea 1
MX - Messico 1
RS - Serbia 1
SK - Slovacchia (Repubblica Slovacca) 1
TW - Taiwan 1
Totale 10.568
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Città #
Fairfield 1.218
Woodbridge 796
Chandler 691
Houston 530
Ashburn 518
Seattle 504
Jacksonville 470
Nyköping 448
Cambridge 440
Wilmington 407
Ann Arbor 403
Bari 187
Roxbury 173
Lawrence 170
Nanjing 163
Dong Ket 157
Beijing 129
Boardman 121
New York 112
Princeton 106
Des Moines 104
Inglewood 70
Brooklyn 60
San Diego 53
Shenyang 40
Jiaxing 36
Nanchang 35
Singapore 34
Dublin 33
Hebei 33
London 30
Dearborn 29
Paris 25
Brussels 22
Changsha 22
Pune 22
Los Angeles 21
Tianjin 21
Norwalk 20
Unterföhring 17
Guangzhou 15
Redwood City 15
Shanghai 15
Rome 13
Falls Church 11
Ardabil 10
Frankfurt am Main 10
Helsinki 10
Boydton 9
Indiana 9
Augusta 8
Leawood 8
San Francisco 8
San Mateo 8
Taizhou 8
West Jordan 8
Jinan 7
Catania 6
Hong Kong 6
Naples 6
Washington 6
Wuhan 6
Wuxi 6
Bitonto 5
Brno 5
Chiswick 5
Ningbo 5
Zhengzhou 5
Acquaviva delle Fonti 4
Islington 4
Jinhua 4
Kansas City 4
Kilburn 4
Monmouth Junction 4
Munich 4
Nuremberg 4
Quanzhou 4
Toronto 4
Acton 3
Dalian 3
Ercolano 3
Fuzhou 3
Hangzhou 3
Hefei 3
Marseille 3
New Bedfont 3
Tappahannock 3
Yiwu 3
Bangalore 2
Bąków 2
Chongqing 2
Clifton 2
Florence 2
Heze 2
Istanbul 2
Krakow 2
Longyan 2
Melbourne 2
Milan 2
Nantong 2
Totale 8.797
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Nome #
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 151
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 133
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 133
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 131
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 127
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 126
5-HT7 receptor activation: procognitive and antiamnesic effects 113
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 111
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 111
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 105
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 104
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 102
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 98
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 97
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 97
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 97
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 97
5 HT1A receptor, an old target for new therapeutic agents 96
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 96
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 95
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 95
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 94
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 93
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 93
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 92
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 91
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 90
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 89
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 89
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 89
Cyclohexyl-substituted piperazine compounds 87
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 86
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 85
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 85
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 83
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 83
The therapeutic potential of 5-HT1A receptors: a patent review. 82
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 82
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 81
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 81
Activatable fluorescent probes: a new concept in optical molecular imaging 81
Serotonin7 Receptors (5-HT7Rs) and their Ligands 81
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 81
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 81
An updated patent review on P-glycoprotein inhibitors (2011-2018) 81
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 80
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 80
Design and synthesis of new selective P-gp substrates and inhibitors. 80
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 79
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 79
METHOD FOR DETERMINING FREE COPPER 79
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 79
null 79
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 78
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 78
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 78
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 76
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 76
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 75
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 75
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 75
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 75
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 74
Structural insights into serotonin receptor ligands polypharmacology 74
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 74
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 74
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 72
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 72
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 71
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 71
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 70
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 70
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 70
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The medicinal chemistry of 5-HT2C receptor ligands 67
Percorsi formativi e figure professionali nella preparazione dei radiofarmaci 66
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 66
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 65
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 65
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 65
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 64
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine 64
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 64
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 64
null 64
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 64
The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat 63
Developments in fluorescent probes for receptor research 63
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[(1-tetralin)alkyl]piperazines. 2 62
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 62
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 60
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 59
Editorial 58
Determination of dopamine D4 receptor density in rat striatum using PB12 as a probe 58
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 57
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 56
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 56
Identification of a red-emitting fluorescent ligand suitable for in vitro 5-HT1A receptor visualization 55
Totale 8.184
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Categoria #
all - tutte 46.893
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 46.893
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20202.424 0 155 107 255 309 184 287 257 326 204 214 126
2020/20211.772 142 129 110 105 147 69 206 128 136 221 136 243
2021/20221.368 66 162 40 55 68 101 66 70 125 75 230 310
2022/20231.973 334 193 136 152 274 238 25 220 321 7 35 38
2023/2024739 54 122 39 34 54 169 21 24 48 28 26 120
2024/2025146 127 19 0 0 0 0 0 0 0 0 0 0
Totale 10.912