IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 10.506
AS - Asia 4.612
EU - Europa 3.257
SA - Sud America 1.249
AF - Africa 177
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 6
Totale 19.816
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Nazione #
US - Stati Uniti d'America 10.319
SG - Singapore 1.836
CN - Cina 1.042
BR - Brasile 986
SE - Svezia 603
IT - Italia 540
HK - Hong Kong 531
VN - Vietnam 502
RU - Federazione Russa 422
DE - Germania 411
FI - Finlandia 251
FR - Francia 239
GB - Regno Unito 238
UA - Ucraina 213
IN - India 148
AR - Argentina 105
BD - Bangladesh 82
CA - Canada 82
ID - Indonesia 74
MX - Messico 65
AT - Austria 61
IQ - Iraq 55
JP - Giappone 46
NL - Olanda 46
EC - Ecuador 41
PL - Polonia 41
ES - Italia 40
IE - Irlanda 40
PK - Pakistan 39
CO - Colombia 34
TR - Turchia 34
BE - Belgio 33
ZA - Sudafrica 33
CI - Costa d'Avorio 31
SA - Arabia Saudita 31
VE - Venezuela 30
UZ - Uzbekistan 25
TN - Tunisia 19
MA - Marocco 18
MY - Malesia 17
PH - Filippine 17
PY - Paraguay 17
CL - Cile 16
KE - Kenya 16
IR - Iran 15
DZ - Algeria 14
NO - Norvegia 14
EG - Egitto 13
KZ - Kazakistan 11
LT - Lituania 11
JM - Giamaica 10
JO - Giordania 10
OM - Oman 10
AZ - Azerbaigian 9
CR - Costa Rica 9
KR - Corea 9
AE - Emirati Arabi Uniti 8
AU - Australia 8
BO - Bolivia 8
NG - Nigeria 8
AL - Albania 7
CZ - Repubblica Ceca 7
ET - Etiopia 7
KG - Kirghizistan 7
PS - Palestinian Territory 7
SY - Repubblica araba siriana 7
IL - Israele 6
NP - Nepal 6
CH - Svizzera 5
GE - Georgia 5
LB - Libano 5
PT - Portogallo 5
RS - Serbia 5
UY - Uruguay 5
EE - Estonia 4
EU - Europa 4
GT - Guatemala 4
PE - Perù 4
RO - Romania 4
SN - Senegal 4
TW - Taiwan 4
BG - Bulgaria 3
KW - Kuwait 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
TH - Thailandia 3
TT - Trinidad e Tobago 3
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BW - Botswana 2
DM - Dominica 2
GD - Grenada 2
GR - Grecia 2
GY - Guiana 2
HN - Honduras 2
HU - Ungheria 2
MD - Moldavia 2
MN - Mongolia 2
TG - Togo 2
XK - ???statistics.table.value.countryCode.XK??? 2
Totale 19.792
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Città #
Fairfield 1.219
Ashburn 958
Singapore 951
Woodbridge 797
Chandler 661
Houston 551
Hong Kong 521
Seattle 517
Jacksonville 482
San Jose 477
Cambridge 444
Nyköping 431
Wilmington 409
Dallas 404
Ann Arbor 403
Beijing 298
Bari 222
Dong Ket 188
Roxbury 175
Lauterbourg 168
Nanjing 167
Lawrence 165
New York 142
Boardman 127
Ho Chi Minh City 122
Des Moines 108
Princeton 106
Helsinki 102
Los Angeles 95
Brooklyn 88
Council Bluffs 84
São Paulo 72
Inglewood 70
Hanoi 66
Santa Clara 57
San Diego 56
Buffalo 53
London 50
Rome 50
Munich 47
Shenyang 43
Jakarta 42
Dublin 41
Vienna 38
Jiaxing 36
Warsaw 36
Nanchang 35
Rio de Janeiro 35
Hebei 34
Abidjan 31
Chicago 31
Nuremberg 30
Brussels 29
Dearborn 29
Frankfurt am Main 29
Tokyo 29
Paris 28
Montreal 26
Pune 25
Shanghai 25
Tashkent 24
Tianjin 24
Baghdad 23
Changsha 23
Guayaquil 23
San Francisco 22
Falkenstein 21
Moscow 21
North Bergen 21
Norwalk 20
The Dalles 20
Denver 19
Dhaka 19
Turku 19
Curitiba 18
Mexico City 17
Orem 17
Stockholm 17
Unterföhring 17
Belo Horizonte 15
Columbus 15
Phoenix 15
Redwood City 15
Toronto 15
Amsterdam 14
Atlanta 14
Brasília 14
Johannesburg 14
Buenos Aires 13
Guangzhou 13
Nairobi 13
Caracas 12
Milan 12
Naples 12
Boston 11
Campinas 11
Chennai 11
Falls Church 11
Goiânia 11
Haiphong 11
Totale 13.412
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Nome #
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 227
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 223
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 211
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 202
5-HT7 receptor activation: procognitive and antiamnesic effects 198
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 189
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 183
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 181
An updated patent review on P-glycoprotein inhibitors (2011-2018) 181
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 178
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 177
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 174
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 170
5 HT1A receptor, an old target for new therapeutic agents 170
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 170
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 169
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 169
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 165
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 164
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 161
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 159
Cyclohexyl-substituted piperazine compounds 156
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 154
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 153
METHOD FOR DETERMINING FREE COPPER 149
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 148
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 147
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 146
Activatable fluorescent probes: a new concept in optical molecular imaging 144
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 144
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 143
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 142
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 140
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 139
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 139
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 136
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 136
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 135
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 134
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 134
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 134
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 133
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 130
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 130
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 127
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 127
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 124
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 124
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 123
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 122
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 121
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 121
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 118
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 117
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 117
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 116
Design and synthesis of new selective P-gp substrates and inhibitors. 115
Structural insights into serotonin receptor ligands polypharmacology 115
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 115
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 114
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 114
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 114
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 113
The therapeutic potential of 5-HT1A receptors: a patent review. 113
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 113
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 113
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 113
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 111
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 111
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 111
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 111
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 111
Serotonin7 Receptors (5-HT7Rs) and their Ligands 110
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 110
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 109
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 109
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 108
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 108
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 108
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 108
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 108
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 107
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 107
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 105
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 104
Editorial 102
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 102
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 102
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 102
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 102
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 102
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 101
The medicinal chemistry of 5-HT2C receptor ligands 101
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 101
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 100
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 100
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 99
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 97
Small and innovative molecules as new strategy to revert MDR 97
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 96
Totale 13.236
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Categoria #
all - tutte 81.058
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 81.058
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021633 0 0 0 0 0 0 0 0 0 223 136 274
2021/20221.384 66 164 40 57 68 102 66 71 126 76 232 316
2022/20231.900 327 182 130 151 268 226 25 207 308 7 33 36
2023/2024708 53 116 38 33 50 153 21 22 53 28 27 114
2024/20253.242 121 26 279 127 94 231 320 288 177 140 492 947
2025/20266.286 939 431 727 813 665 364 836 264 692 555 0 0
Totale 20.290