IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 11.891
AS - Asia 4.708
EU - Europa 4.085
SA - Sud America 1.245
Continente sconosciuto - Info sul continente non disponibili 497
AF - Africa 171
OC - Oceania 9
Totale 22.606
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Nazione #
US - Stati Uniti d'America 11.639
SG - Singapore 1.846
IT - Italia 1.338
CN - Cina 1.063
BR - Brasile 969
SE - Svezia 595
HK - Hong Kong 537
VN - Vietnam 500
RU - Federazione Russa 419
DE - Germania 411
FI - Finlandia 251
FR - Francia 242
GB - Regno Unito 241
UA - Ucraina 213
IN - India 147
BD - Bangladesh 138
CA - Canada 118
AR - Argentina 106
ID - Indonesia 75
MX - Messico 69
AT - Austria 59
IQ - Iraq 55
NL - Olanda 55
JP - Giappone 48
PL - Polonia 48
ES - Italia 44
EC - Ecuador 41
CO - Colombia 40
IE - Irlanda 40
PK - Pakistan 40
TR - Turchia 35
SA - Arabia Saudita 34
BE - Belgio 33
ZA - Sudafrica 33
VE - Venezuela 32
CI - Costa d'Avorio 31
NO - Norvegia 25
UZ - Uzbekistan 25
MY - Malesia 20
MA - Marocco 18
TN - Tunisia 18
CL - Cile 17
PY - Paraguay 17
KE - Kenya 16
IR - Iran 15
PH - Filippine 15
DZ - Algeria 14
CR - Costa Rica 13
JM - Giamaica 13
EG - Egitto 12
JO - Giordania 10
KR - Corea 10
LT - Lituania 10
OM - Oman 10
AZ - Azerbaigian 9
KZ - Kazakistan 9
AE - Emirati Arabi Uniti 8
AL - Albania 8
AU - Australia 8
BO - Bolivia 8
CZ - Repubblica Ceca 8
ET - Etiopia 7
NG - Nigeria 7
SY - Repubblica araba siriana 7
TT - Trinidad e Tobago 7
UY - Uruguay 7
IL - Israele 6
KG - Kirghizistan 6
NP - Nepal 6
PS - Palestinian Territory 6
RO - Romania 6
CH - Svizzera 5
GE - Georgia 5
GT - Guatemala 5
LB - Libano 5
PE - Perù 5
PT - Portogallo 5
RS - Serbia 5
BB - Barbados 4
BG - Bulgaria 4
EE - Estonia 4
EU - Europa 4
PA - Panama 4
SN - Senegal 4
TW - Taiwan 4
DM - Dominica 3
HN - Honduras 3
MD - Moldavia 3
NI - Nicaragua 3
PR - Porto Rico 3
SK - Slovacchia (Repubblica Slovacca) 3
TH - Thailandia 3
BA - Bosnia-Erzegovina 2
BS - Bahamas 2
BW - Botswana 2
GD - Grenada 2
GR - Grecia 2
GY - Guiana 2
HU - Ungheria 2
KW - Kuwait 2
Totale 22.086
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Città #
Fairfield 1.219
Ashburn 1.050
Singapore 955
Woodbridge 797
San Jose 661
Chandler 656
Houston 557
Hong Kong 526
Seattle 517
Jacksonville 485
Dallas 448
Cambridge 445
Milan 438
Nyköping 422
Wilmington 412
Ann Arbor 403
Beijing 306
Council Bluffs 262
Los Angeles 230
Bari 229
Dong Ket 188
New York 175
Roxbury 175
Rome 170
Lauterbourg 168
Nanjing 167
Lawrence 158
Boardman 153
Ho Chi Minh City 120
Des Moines 109
Princeton 106
Helsinki 102
Brooklyn 97
Santa Clara 90
São Paulo 73
Inglewood 70
Hanoi 66
Buffalo 62
San Diego 56
London 53
Columbus 48
Figino 47
Munich 47
Chicago 43
Shenyang 43
Dublin 42
Jakarta 42
Warsaw 41
San Francisco 39
Jiaxing 36
Montreal 36
Vienna 36
Nanchang 35
Rio de Janeiro 35
Denver 34
Hebei 34
Phoenix 34
Abidjan 31
Tokyo 31
Frankfurt am Main 30
Brussels 29
Dearborn 29
Nuremberg 29
Naples 28
Paris 28
Atlanta 24
Pune 24
Shanghai 24
Tashkent 24
Tianjin 24
Baghdad 23
Changsha 23
North Bergen 23
Orem 23
The Dalles 23
Toronto 23
Guayaquil 22
Falkenstein 21
Moscow 21
Turin 21
Bjørkelangen 20
Mexico City 20
Norwalk 20
Turku 19
Curitiba 18
Dhaka 18
Stockholm 18
Unterföhring 17
Redwood City 16
Belo Horizonte 15
Buenos Aires 15
Amsterdam 14
Bologna 14
Brasília 14
Johannesburg 14
Boston 13
Guangzhou 13
Nairobi 13
Washington 13
Catania 12
Totale 14.942
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Nome #
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 457
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 247
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 238
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 221
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 214
5-HT7 receptor activation: procognitive and antiamnesic effects 206
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 196
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 194
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 194
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 191
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 187
An updated patent review on P-glycoprotein inhibitors (2011-2018) 187
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 186
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 186
5 HT1A receptor, an old target for new therapeutic agents 183
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 180
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 179
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 178
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 176
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 176
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 175
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 175
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 174
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 174
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 173
Cyclohexyl-substituted piperazine compounds 173
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 168
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 168
METHOD FOR DETERMINING FREE COPPER 162
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 158
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 158
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 155
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 155
Activatable fluorescent probes: a new concept in optical molecular imaging 153
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 152
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 150
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 150
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 149
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 149
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 149
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 148
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 146
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 145
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 144
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 144
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 144
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 142
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 141
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 141
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 135
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 133
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 133
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 130
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 129
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 129
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 127
Structural insights into serotonin receptor ligands polypharmacology 127
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 127
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 126
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 125
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 125
Editorial 122
Design and synthesis of new selective P-gp substrates and inhibitors. 122
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 122
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 122
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 122
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 121
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 120
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 120
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 120
The therapeutic potential of 5-HT1A receptors: a patent review. 120
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 119
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 119
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 119
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 119
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 118
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 118
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 117
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 117
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 116
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 116
Radiofarmaci 116
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 116
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 114
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 114
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 114
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 114
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 114
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 113
FPR2 and brimstone: a novel approach for the treatment of neuroinflammation 112
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 112
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 112
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 112
Serotonin7 Receptors (5-HT7Rs) and their Ligands 112
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 110
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 109
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 108
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 107
The medicinal chemistry of 5-HT2C receptor ligands 107
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 106
Totale 14.748
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Categoria #
all - tutte 90.270
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 90.270
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.154 0 0 40 57 68 102 66 71 126 76 232 316
2022/20231.872 319 179 128 150 267 222 25 203 303 7 33 36
2023/2024693 53 114 38 32 48 150 20 19 53 27 27 112
2024/20253.194 120 26 277 123 93 230 315 287 175 137 483 928
2025/20267.470 918 419 719 808 660 362 826 262 674 671 307 844
2026/20271.223 296 553 374 0 0 0 0 0 0 0 0 0
Totale 22.606