IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
Salva come PNG Salva come JPEG
Continente #
NA - Nord America 9.592
AS - Asia 3.758
EU - Europa 2.790
SA - Sud America 1.029
AF - Africa 99
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 5
Totale 17.281
Salva come PNG Salva come JPEG
Nazione #
US - Stati Uniti d'America 9.458
SG - Singapore 1.556
CN - Cina 930
BR - Brasile 876
SE - Svezia 599
HK - Hong Kong 495
IT - Italia 447
VN - Vietnam 417
RU - Federazione Russa 407
DE - Germania 383
GB - Regno Unito 224
UA - Ucraina 205
FI - Finlandia 169
IN - India 78
AR - Argentina 65
CA - Canada 64
FR - Francia 62
AT - Austria 61
ID - Indonesia 59
MX - Messico 46
NL - Olanda 40
IE - Irlanda 39
PL - Polonia 36
BD - Bangladesh 35
JP - Giappone 34
BE - Belgio 32
CI - Costa d'Avorio 31
EC - Ecuador 30
ES - Italia 29
ZA - Sudafrica 22
IQ - Iraq 19
VE - Venezuela 17
TR - Turchia 16
IR - Iran 15
CO - Colombia 14
SA - Arabia Saudita 14
UZ - Uzbekistan 12
LT - Lituania 11
PK - Pakistan 11
KE - Kenya 9
PY - Paraguay 9
AU - Australia 8
CL - Cile 8
KR - Corea 8
NO - Norvegia 8
AL - Albania 7
AZ - Azerbaigian 7
EG - Egitto 7
MA - Marocco 7
TN - Tunisia 7
CZ - Repubblica Ceca 6
IL - Israele 6
JM - Giamaica 6
OM - Oman 6
CH - Svizzera 5
CR - Costa Rica 5
DZ - Algeria 5
AE - Emirati Arabi Uniti 4
EE - Estonia 4
EU - Europa 4
GE - Georgia 4
JO - Giordania 4
KZ - Kazakistan 4
NG - Nigeria 4
RO - Romania 4
UY - Uruguay 4
ET - Etiopia 3
KG - Kirghizistan 3
PT - Portogallo 3
SY - Repubblica araba siriana 3
TT - Trinidad e Tobago 3
TW - Taiwan 3
BB - Barbados 2
BG - Bulgaria 2
DM - Dominica 2
GY - Guiana 2
HN - Honduras 2
KW - Kuwait 2
LB - Libano 2
MY - Malesia 2
NP - Nepal 2
PE - Perù 2
PS - Palestinian Territory 2
SK - Slovacchia (Repubblica Slovacca) 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GI - Gibilterra 1
GR - Grecia 1
GT - Guatemala 1
MK - Macedonia 1
ML - Mali 1
MN - Mongolia 1
NI - Nicaragua 1
PA - Panama 1
Totale 17.276
Salva come PNG Salva come JPEG
Città #
Fairfield 1.219
Ashburn 850
Woodbridge 796
Singapore 735
Chandler 661
Houston 549
Seattle 516
Hong Kong 487
Jacksonville 482
Cambridge 444
Nyköping 431
Wilmington 409
Ann Arbor 403
Dallas 394
Beijing 283
Bari 218
Dong Ket 188
Roxbury 175
Lawrence 165
Nanjing 165
New York 133
Boardman 127
Des Moines 106
Princeton 106
Ho Chi Minh City 99
Los Angeles 89
Brooklyn 86
Inglewood 70
São Paulo 60
San Diego 54
Buffalo 53
London 47
Munich 47
Rome 45
Hanoi 43
Santa Clara 43
Shenyang 43
Jakarta 41
Dublin 40
Vienna 38
Jiaxing 36
Nanchang 35
Hebei 34
Warsaw 32
Abidjan 31
Brussels 29
Dearborn 29
Nuremberg 28
Paris 28
Chicago 27
Rio de Janeiro 27
Council Bluffs 26
Frankfurt am Main 25
Pune 24
Changsha 23
Shanghai 23
Tianjin 23
Montreal 22
Tokyo 22
North Bergen 21
Helsinki 20
Moscow 20
Norwalk 20
San Francisco 19
Turku 19
Unterföhring 17
Denver 16
Columbus 15
Guayaquil 15
Redwood City 15
Toronto 15
Curitiba 14
The Dalles 14
Amsterdam 13
Belo Horizonte 13
Brasília 13
Guangzhou 13
Phoenix 13
Stockholm 13
Atlanta 12
Tashkent 12
Boston 11
Falls Church 11
Langenzersdorf 11
Salt Lake City 11
Sorocaba 11
Ardabil 10
Haiphong 10
Johannesburg 10
Mexico City 10
Naples 10
Biên Hòa 9
Boydton 9
Fortaleza 9
Indiana 9
Manchester 9
Milan 9
Poplar 9
Augusta 8
Falkenstein 8
Totale 11.990
Salva come PNG Salva come JPEG
Nome #
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 211
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 193
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 192
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 180
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 179
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 170
5-HT7 receptor activation: procognitive and antiamnesic effects 168
An updated patent review on P-glycoprotein inhibitors (2011-2018) 164
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 162
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 161
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 159
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 157
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 156
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 155
5 HT1A receptor, an old target for new therapeutic agents 153
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 149
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 148
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 147
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 146
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 145
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 143
Cyclohexyl-substituted piperazine compounds 142
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 137
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 137
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 134
Activatable fluorescent probes: a new concept in optical molecular imaging 131
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 130
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 129
METHOD FOR DETERMINING FREE COPPER 129
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 129
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 127
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 127
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 125
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 121
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 121
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 120
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 120
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 120
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 120
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 118
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 117
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 115
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 115
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 114
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 114
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 113
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 112
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 111
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 110
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 110
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 108
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 108
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 108
Structural insights into serotonin receptor ligands polypharmacology 108
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 107
Design and synthesis of new selective P-gp substrates and inhibitors. 106
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 105
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 105
The therapeutic potential of 5-HT1A receptors: a patent review. 104
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 104
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 104
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 103
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 103
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 102
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 102
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 101
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 101
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 101
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 101
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 100
Serotonin7 Receptors (5-HT7Rs) and their Ligands 100
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 100
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 99
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 99
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 99
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 99
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 97
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 97
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 97
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 96
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 95
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 95
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 95
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 95
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 94
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 92
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 92
The medicinal chemistry of 5-HT2C receptor ligands 91
Editorial 90
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 90
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 90
Percorsi formativi e figure professionali nella preparazione dei radiofarmaci 90
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 89
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 88
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 87
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 87
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 86
Developments in fluorescent probes for receptor research 85
Totale 11.892
Salva come PNG Salva come JPEG
Categoria #
all - tutte 76.031
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.031
Salva come PNG Salva come JPEG


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.175 0 0 0 0 0 69 207 128 138 223 136 274
2021/20221.384 66 164 40 57 68 102 66 71 126 76 232 316
2022/20231.900 327 182 130 151 268 226 25 207 308 7 33 36
2023/2024708 53 116 38 33 50 153 21 22 53 28 27 114
2024/20253.242 121 26 279 127 94 231 320 288 177 140 492 947
2025/20263.746 939 431 727 813 665 171 0 0 0 0 0 0
Totale 17.750