IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 11.063
AS - Asia 4.654
EU - Europa 4.041
SA - Sud America 1.226
AF - Africa 171
OC - Oceania 9
Continente sconosciuto - Info sul continente non disponibili 6
Totale 21.170
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Nazione #
US - Stati Uniti d'America 10.853
SG - Singapore 1.837
IT - Italia 1.309
CN - Cina 1.058
BR - Brasile 964
SE - Svezia 594
HK - Hong Kong 533
VN - Vietnam 498
RU - Federazione Russa 419
DE - Germania 410
FI - Finlandia 251
FR - Francia 242
GB - Regno Unito 237
UA - Ucraina 213
IN - India 145
BD - Bangladesh 119
AR - Argentina 105
CA - Canada 92
ID - Indonesia 73
MX - Messico 67
AT - Austria 59
IQ - Iraq 55
NL - Olanda 54
JP - Giappone 47
PL - Polonia 45
ES - Italia 41
EC - Ecuador 40
IE - Irlanda 40
PK - Pakistan 39
CO - Colombia 34
TR - Turchia 34
BE - Belgio 33
ZA - Sudafrica 33
CI - Costa d'Avorio 31
SA - Arabia Saudita 29
VE - Venezuela 28
NO - Norvegia 25
UZ - Uzbekistan 25
MA - Marocco 18
TN - Tunisia 18
CL - Cile 17
MY - Malesia 17
PY - Paraguay 17
KE - Kenya 16
IR - Iran 15
PH - Filippine 15
DZ - Algeria 14
EG - Egitto 12
JM - Giamaica 12
CR - Costa Rica 11
JO - Giordania 10
KR - Corea 10
LT - Lituania 10
OM - Oman 10
AZ - Azerbaigian 9
KZ - Kazakistan 9
AE - Emirati Arabi Uniti 8
AU - Australia 8
BO - Bolivia 8
CZ - Repubblica Ceca 8
AL - Albania 7
ET - Etiopia 7
NG - Nigeria 7
SY - Repubblica araba siriana 7
IL - Israele 6
KG - Kirghizistan 6
NP - Nepal 6
PS - Palestinian Territory 6
RO - Romania 6
CH - Svizzera 5
GE - Georgia 5
GT - Guatemala 5
LB - Libano 5
PE - Perù 5
PT - Portogallo 5
RS - Serbia 5
UY - Uruguay 5
BG - Bulgaria 4
EE - Estonia 4
EU - Europa 4
SN - Senegal 4
TT - Trinidad e Tobago 4
TW - Taiwan 4
HN - Honduras 3
MD - Moldavia 3
PA - Panama 3
SK - Slovacchia (Repubblica Slovacca) 3
TH - Thailandia 3
BA - Bosnia-Erzegovina 2
BB - Barbados 2
BS - Bahamas 2
BW - Botswana 2
DM - Dominica 2
GD - Grenada 2
GR - Grecia 2
GY - Guiana 2
HU - Ungheria 2
KW - Kuwait 2
MN - Mongolia 2
PR - Porto Rico 2
Totale 21.144
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Città #
Fairfield 1.219
Ashburn 997
Singapore 948
Woodbridge 797
Chandler 656
San Jose 576
Houston 556
Hong Kong 522
Seattle 517
Jacksonville 484
Cambridge 445
Milan 437
Nyköping 422
Wilmington 410
Dallas 404
Ann Arbor 403
Beijing 303
Bari 228
Los Angeles 210
Dong Ket 188
Roxbury 175
Lauterbourg 168
Rome 168
Nanjing 167
Lawrence 158
New York 157
Boardman 151
Ho Chi Minh City 120
Des Moines 108
Princeton 106
Helsinki 102
Brooklyn 92
Council Bluffs 84
Santa Clara 71
Inglewood 70
São Paulo 70
Hanoi 66
Buffalo 59
San Diego 56
London 51
Columbus 48
Figino 47
Munich 47
Shenyang 43
Jakarta 42
Dublin 41
Warsaw 38
Jiaxing 36
Vienna 36
Nanchang 35
Chicago 34
Hebei 34
Rio de Janeiro 34
Abidjan 31
Tokyo 30
Brussels 29
Dearborn 29
Frankfurt am Main 29
Nuremberg 29
Paris 28
Montreal 27
Pune 24
Shanghai 24
Tashkent 24
Tianjin 24
Baghdad 23
Changsha 23
Naples 23
San Francisco 23
The Dalles 23
Guayaquil 22
North Bergen 22
Denver 21
Falkenstein 21
Moscow 21
Turin 21
Atlanta 20
Bjørkelangen 20
Norwalk 20
Mexico City 19
Turku 19
Curitiba 18
Dhaka 18
Orem 17
Stockholm 17
Unterföhring 17
Phoenix 16
Redwood City 16
Belo Horizonte 15
Toronto 15
Amsterdam 14
Bologna 14
Brasília 14
Buenos Aires 14
Johannesburg 14
Guangzhou 13
Nairobi 13
Catania 12
Washington 12
Boston 11
Totale 14.385
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Nome #
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 242
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 237
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 219
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 211
5-HT7 receptor activation: procognitive and antiamnesic effects 203
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 195
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 193
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 191
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 188
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 184
An updated patent review on P-glycoprotein inhibitors (2011-2018) 183
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 182
5 HT1A receptor, an old target for new therapeutic agents 179
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 177
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 176
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 176
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 175
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 172
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 171
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 171
Cyclohexyl-substituted piperazine compounds 171
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 171
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 169
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 166
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 166
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 166
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 163
METHOD FOR DETERMINING FREE COPPER 158
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 153
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 153
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 153
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 152
Activatable fluorescent probes: a new concept in optical molecular imaging 152
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 149
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 147
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 147
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 147
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 146
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 146
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 145
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 143
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 143
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 142
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 142
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 141
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 139
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 138
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 134
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 134
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 131
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 129
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 127
Structural insights into serotonin receptor ligands polypharmacology 127
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 126
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 126
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 125
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 123
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 123
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 122
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 121
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 121
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 119
The therapeutic potential of 5-HT1A receptors: a patent review. 119
Design and synthesis of new selective P-gp substrates and inhibitors. 119
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 119
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 119
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 118
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 118
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 118
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 118
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 117
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 117
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 116
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 116
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 116
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 116
Editorial 115
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 115
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 115
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 114
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 114
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 113
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 112
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 112
Radiofarmaci 112
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 112
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 111
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 111
Serotonin7 Receptors (5-HT7Rs) and their Ligands 111
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 110
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 110
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 108
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 108
FPR2 and brimstone: a novel approach for the treatment of neuroinflammation 107
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 107
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 107
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 105
The medicinal chemistry of 5-HT2C receptor ligands 105
Small and innovative molecules as new strategy to revert MDR 104
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 103
Totale 14.108
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Categoria #
all - tutte 86.968
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 86.968
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.384 66 164 40 57 68 102 66 71 126 76 232 316
2022/20231.872 319 179 128 150 267 222 25 203 303 7 33 36
2023/2024693 53 114 38 32 48 150 20 19 53 27 27 112
2024/20253.194 120 26 277 123 93 230 315 287 175 137 483 928
2025/20267.470 918 419 719 808 660 362 826 262 674 671 307 844
2026/2027278 278 0 0 0 0 0 0 0 0 0 0 0
Totale 21.661