IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 7.795
EU - Europa 1.745
AS - Asia 727
OC - Oceania 6
Continente sconosciuto - Info sul continente non disponibili 4
SA - Sud America 2
Totale 10.279
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Nazione #
US - Stati Uniti d'America 7.787
SE - Svezia 600
CN - Cina 509
IT - Italia 289
DE - Germania 239
UA - Ucraina 192
VN - Vietnam 157
GB - Regno Unito 151
FI - Finlandia 140
FR - Francia 45
IE - Irlanda 33
IN - India 29
BE - Belgio 24
RU - Federazione Russa 19
IR - Iran 14
HK - Hong Kong 7
AU - Australia 6
CA - Canada 5
JP - Giappone 5
EU - Europa 4
PL - Polonia 3
AT - Austria 2
CL - Cile 2
DM - Dominica 2
ID - Indonesia 2
NL - Olanda 2
RO - Romania 2
BG - Bulgaria 1
GR - Grecia 1
IL - Israele 1
MX - Messico 1
RS - Serbia 1
SG - Singapore 1
SK - Slovacchia (Repubblica Slovacca) 1
TR - Turchia 1
TW - Taiwan 1
Totale 10.279
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Città #
Fairfield 1.218
Woodbridge 796
Chandler 691
Houston 530
Ashburn 517
Seattle 504
Jacksonville 470
Nyköping 448
Cambridge 440
Wilmington 407
Ann Arbor 403
Bari 185
Roxbury 173
Lawrence 170
Nanjing 163
Dong Ket 157
Beijing 116
New York 112
Princeton 106
Des Moines 104
Boardman 73
Inglewood 70
Brooklyn 60
San Diego 53
Shenyang 40
Nanchang 35
Dublin 33
Hebei 33
Jiaxing 32
London 30
Dearborn 29
Paris 25
Brussels 22
Changsha 22
Pune 22
Tianjin 21
Norwalk 20
Los Angeles 17
Redwood City 15
Rome 13
Falls Church 11
Ardabil 10
Frankfurt am Main 10
Helsinki 10
Boydton 9
Indiana 9
Augusta 8
Leawood 8
San Francisco 8
San Mateo 8
West Jordan 8
Jinan 7
Catania 6
Hong Kong 6
Naples 6
Washington 6
Bitonto 5
Chiswick 5
Ningbo 5
Taizhou 5
Zhengzhou 5
Acquaviva delle Fonti 4
Islington 4
Kansas City 4
Kilburn 4
Monmouth Junction 4
Toronto 4
Acton 3
Ercolano 3
Guangzhou 3
Hefei 3
Marseille 3
New Bedfont 3
Shanghai 3
Tappahannock 3
Bangalore 2
Florence 2
Fuzhou 2
Hangzhou 2
Krakow 2
Melbourne 2
Milan 2
Ostuni 2
Philadelphia 2
Prescot 2
Roseau 2
Sannicandro di Bari 2
Strasbourg 2
Vienna 2
Waanrode 2
Aci Bonaccorsi 1
Adelfia 1
Alghero 1
Auburn Hills 1
Belgrade 1
Bratislava 1
Brisbane 1
Canberra 1
Castellammare Di Stabia 1
Catanzaro 1
Totale 8.618
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Nome #
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 148
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 132
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 129
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 128
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 124
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 121
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 111
5-HT7 receptor activation: procognitive and antiamnesic effects 111
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 108
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 102
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 101
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 100
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 97
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 97
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 95
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 95
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 95
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 94
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 93
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 93
5 HT1A receptor, an old target for new therapeutic agents 92
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 92
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 92
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 91
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 89
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 88
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 88
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 87
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 86
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 86
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 86
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 84
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 84
The therapeutic potential of 5-HT1A receptors: a patent review. 82
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 82
Serotonin7 Receptors (5-HT7Rs) and their Ligands 81
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 81
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 80
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 80
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 79
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 79
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 79
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 79
An updated patent review on P-glycoprotein inhibitors (2011-2018) 79
Activatable fluorescent probes: a new concept in optical molecular imaging 78
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 78
Design and synthesis of new selective P-gp substrates and inhibitors. 78
null 78
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 77
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 77
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 77
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 77
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 77
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 76
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 76
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 76
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 75
Structural insights into serotonin receptor ligands polypharmacology 74
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 74
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 74
METHOD FOR DETERMINING FREE COPPER 73
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 73
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 72
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 72
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 72
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 71
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 71
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 71
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 70
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 70
null 69
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 69
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 68
Cyclohexyl-substituted piperazine compounds 68
null 68
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 67
The medicinal chemistry of 5-HT2C receptor ligands 67
Percorsi formativi e figure professionali nella preparazione dei radiofarmaci 66
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 65
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 65
Synthesis and biological evaluation of potential positron emission tomography (PET) ligands for brain visualization of dopamine D3 receptors 64
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 64
null 64
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 64
Oxygen isosteric derivatives of 3-(3-hydroxyphenyl)-N-n-propylpiperidine 63
The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat 63
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 63
Developments in fluorescent probes for receptor research 63
High affinity and selectivity on 5-HT1A receptor of 1-aryl-4-[(1-tetralin)alkyl]piperazines. 2 62
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 62
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 61
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 60
Determination of dopamine D4 receptor density in rat striatum using PB12 as a probe 58
New 1-arylpiperazinic ligands of 5-HT7 receptor and use thereof 58
Studies on 1-arylpiperazine derivatives with affinity for rat 5-HT7 and 5-HT1A receptors 57
Editorial 55
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 54
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 54
PET radiotracers for imaging P-glycoprotein: the challenge for early diagnosis in AD 54
Design, synthesis, and binding affinities of potential positron emission tomography (PET) ligands with optimal lipophilicity for brain imaging of the dopamine D3 receptor. Part II 54
Totale 8.006
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Categoria #
all - tutte 42.699
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 42.699
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019880 0 0 0 0 0 0 0 0 0 172 359 349
2019/20202.903 479 155 107 255 309 184 287 257 326 204 214 126
2020/20211.772 142 129 110 105 147 69 206 128 136 221 136 243
2021/20221.368 66 162 40 55 68 101 66 70 125 75 230 310
2022/20231.973 334 193 136 152 274 238 25 220 321 7 35 38
2023/2024593 54 122 39 34 54 169 21 24 48 28 0 0
Totale 10.620