IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 13.114
AS - Asia 4.739
EU - Europa 4.401
SA - Sud America 1.266
Continente sconosciuto - Info sul continente non disponibili 514
AF - Africa 179
OC - Oceania 9
Totale 24.222
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Nazione #
US - Stati Uniti d'America 12.694
SG - Singapore 1.846
IT - Italia 1.433
CN - Cina 1.064
BR - Brasile 989
SE - Svezia 595
HK - Hong Kong 540
VN - Vietnam 500
RU - Federazione Russa 453
DE - Germania 414
GB - Regno Unito 256
FI - Finlandia 251
FR - Francia 245
UA - Ucraina 214
CA - Canada 177
LT - Lituania 161
IN - India 147
BD - Bangladesh 139
AR - Argentina 106
ID - Indonesia 75
MX - Messico 70
AT - Austria 60
NL - Olanda 58
IQ - Iraq 55
PL - Polonia 50
JP - Giappone 48
ES - Italia 46
CO - Colombia 41
EC - Ecuador 41
IE - Irlanda 40
PK - Pakistan 40
SA - Arabia Saudita 35
TR - Turchia 35
BE - Belgio 34
ZA - Sudafrica 33
VE - Venezuela 32
CI - Costa d'Avorio 31
IL - Israele 28
CR - Costa Rica 25
NO - Norvegia 25
UZ - Uzbekistan 25
TT - Trinidad e Tobago 22
GT - Guatemala 21
JM - Giamaica 21
MY - Malesia 20
SV - El Salvador 19
MA - Marocco 18
TN - Tunisia 18
CL - Cile 17
PR - Porto Rico 17
PY - Paraguay 17
KE - Kenya 16
PH - Filippine 16
IR - Iran 15
CW - ???statistics.table.value.countryCode.CW??? 14
DZ - Algeria 14
HN - Honduras 14
EG - Egitto 12
JO - Giordania 10
KR - Corea 10
KZ - Kazakistan 10
NI - Nicaragua 10
OM - Oman 10
AZ - Azerbaigian 9
SC - Seychelles 9
AE - Emirati Arabi Uniti 8
AL - Albania 8
AU - Australia 8
BO - Bolivia 8
CZ - Repubblica Ceca 8
ET - Etiopia 7
NG - Nigeria 7
SY - Repubblica araba siriana 7
UY - Uruguay 7
EE - Estonia 6
KG - Kirghizistan 6
NP - Nepal 6
PS - Palestinian Territory 6
RO - Romania 6
CH - Svizzera 5
GE - Georgia 5
GP - Guadalupe 5
LB - Libano 5
PE - Perù 5
PT - Portogallo 5
RS - Serbia 5
BB - Barbados 4
BG - Bulgaria 4
EU - Europa 4
PA - Panama 4
SN - Senegal 4
TH - Thailandia 4
TW - Taiwan 4
BS - Bahamas 3
DK - Danimarca 3
DM - Dominica 3
MD - Moldavia 3
SK - Slovacchia (Repubblica Slovacca) 3
BA - Bosnia-Erzegovina 2
BW - Botswana 2
Totale 23.690
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Città #
Ashburn 1.245
Fairfield 1.220
Singapore 955
San Jose 856
Woodbridge 797
Chandler 656
Houston 564
Hong Kong 526
Seattle 519
Jacksonville 487
Dallas 456
Milan 447
Cambridge 445
Nyköping 422
Wilmington 412
Ann Arbor 403
Beijing 306
Council Bluffs 280
Los Angeles 258
Bari 230
New York 196
Dong Ket 188
Rome 180
Roxbury 175
Boardman 171
Lauterbourg 168
Nanjing 167
Lawrence 158
Vilnius 153
Ho Chi Minh City 120
Santa Clara 116
Des Moines 110
Princeton 106
Helsinki 102
Brooklyn 100
São Paulo 89
Inglewood 70
Hanoi 66
Buffalo 62
Washington 61
San Diego 56
London 53
Columbus 51
Figino 47
Munich 47
North Bergen 47
Chicago 43
Shenyang 43
Dublin 42
Jakarta 42
Montreal 42
San Francisco 42
Warsaw 42
Phoenix 37
Vienna 37
Denver 36
Jiaxing 36
Rio de Janeiro 36
Toronto 36
Nanchang 35
Hebei 34
Naples 33
Abidjan 31
Frankfurt am Main 31
Tokyo 31
Brussels 30
Dearborn 29
Nuremberg 29
Paris 28
Atlanta 27
The Dalles 27
Orem 24
Pune 24
Shanghai 24
Tashkent 24
Tianjin 24
Turin 24
Baghdad 23
Changsha 23
Guayaquil 22
Falkenstein 21
Moscow 21
Bjørkelangen 20
Mexico City 20
Norwalk 20
Turku 19
Curitiba 18
Dhaka 18
Stockholm 18
Unterföhring 17
Bologna 16
Redwood City 16
San José 16
Amsterdam 15
Belo Horizonte 15
Brasília 15
Buenos Aires 15
Boston 14
Johannesburg 14
Kingston 14
Totale 15.776
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Nome #
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 465
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 307
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 295
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 244
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 235
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 228
5-HT7 receptor activation: procognitive and antiamnesic effects 216
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 202
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 201
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 198
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 197
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 196
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 191
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 191
An updated patent review on P-glycoprotein inhibitors (2011-2018) 190
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 189
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 187
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 187
5 HT1A receptor, an old target for new therapeutic agents 186
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 186
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 185
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 185
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 182
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 182
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 181
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 181
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 180
Cyclohexyl-substituted piperazine compounds 176
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 175
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 173
METHOD FOR DETERMINING FREE COPPER 168
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 161
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 161
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 160
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 158
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 157
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 156
Activatable fluorescent probes: a new concept in optical molecular imaging 155
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 155
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 155
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 155
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 153
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 152
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 151
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 150
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 148
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 148
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 146
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 144
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 144
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 144
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 143
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 140
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 138
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 136
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 135
Structural insights into serotonin receptor ligands polypharmacology 134
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 133
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 133
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 132
Design and synthesis of new selective P-gp substrates and inhibitors. 131
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 131
FPR2 and brimstone: a novel approach for the treatment of neuroinflammation 130
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 129
Editorial 128
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 128
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 128
Radiofarmaci 127
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 126
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 126
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 126
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 126
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 125
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 125
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach 124
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 124
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 124
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 124
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 124
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 123
The therapeutic potential of 5-HT1A receptors: a patent review. 123
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 123
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 122
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 122
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 122
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 121
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 120
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 120
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 120
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 120
Mitochondrial membranes of human SH-SY5Y neuroblastoma cells express serotonin 5-HT7 receptor 119
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 118
5-HT7 Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn 117
Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists 117
Serotonin7 Receptors (5-HT7Rs) and their Ligands 117
Privileged scaffold-based design to identify a novel drug-like 5-HT7 receptor-preferring agonist to target Fragile X syndrome 117
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 116
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 115
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 115
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 114
Totale 15.643
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Categoria #
all - tutte 95.648
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 95.648
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.057 0 0 0 0 68 102 66 71 126 76 232 316
2022/20231.872 319 179 128 150 267 222 25 203 303 7 33 36
2023/2024693 53 114 38 32 48 150 20 19 53 27 27 112
2024/20253.194 120 26 277 123 93 230 315 287 175 137 483 928
2025/20267.470 918 419 719 808 660 362 826 262 674 671 307 844
2026/20272.839 296 553 605 1.177 208 0 0 0 0 0 0 0
Totale 24.222