IRIS
LEOPOLDO, Marcello
 Distribuzione geografica
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Continente #
NA - Nord America 9.627
AS - Asia 3.833
EU - Europa 2.800
SA - Sud America 1.038
AF - Africa 103
OC - Oceania 8
Continente sconosciuto - Info sul continente non disponibili 5
Totale 17.414
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Nazione #
US - Stati Uniti d'America 9.490
SG - Singapore 1.577
CN - Cina 936
BR - Brasile 882
SE - Svezia 600
HK - Hong Kong 498
VN - Vietnam 453
IT - Italia 451
RU - Federazione Russa 407
DE - Germania 383
GB - Regno Unito 227
UA - Ucraina 205
FI - Finlandia 169
IN - India 78
AR - Argentina 66
CA - Canada 64
FR - Francia 62
AT - Austria 61
ID - Indonesia 59
MX - Messico 48
NL - Olanda 40
IE - Irlanda 39
BD - Bangladesh 38
JP - Giappone 36
PL - Polonia 36
BE - Belgio 32
CI - Costa d'Avorio 31
EC - Ecuador 30
ES - Italia 29
ZA - Sudafrica 24
IQ - Iraq 20
VE - Venezuela 18
TR - Turchia 16
IR - Iran 15
CO - Colombia 14
SA - Arabia Saudita 14
UZ - Uzbekistan 12
LT - Lituania 11
PK - Pakistan 11
NO - Norvegia 10
CL - Cile 9
KE - Kenya 9
PY - Paraguay 9
AU - Australia 8
AZ - Azerbaigian 8
KR - Corea 8
AL - Albania 7
EG - Egitto 7
MA - Marocco 7
TN - Tunisia 7
CZ - Repubblica Ceca 6
DZ - Algeria 6
IL - Israele 6
JM - Giamaica 6
OM - Oman 6
CH - Svizzera 5
CR - Costa Rica 5
NG - Nigeria 5
AE - Emirati Arabi Uniti 4
EE - Estonia 4
EU - Europa 4
GE - Georgia 4
JO - Giordania 4
KZ - Kazakistan 4
RO - Romania 4
SY - Repubblica araba siriana 4
TW - Taiwan 4
UY - Uruguay 4
ET - Etiopia 3
KG - Kirghizistan 3
PT - Portogallo 3
TT - Trinidad e Tobago 3
BB - Barbados 2
BG - Bulgaria 2
DM - Dominica 2
GY - Guiana 2
HN - Honduras 2
KW - Kuwait 2
LB - Libano 2
MY - Malesia 2
NP - Nepal 2
PE - Perù 2
PS - Palestinian Territory 2
SK - Slovacchia (Repubblica Slovacca) 2
AO - Angola 1
BA - Bosnia-Erzegovina 1
BH - Bahrain 1
BN - Brunei Darussalam 1
BO - Bolivia 1
BW - Botswana 1
CY - Cipro 1
DO - Repubblica Dominicana 1
GD - Grenada 1
GI - Gibilterra 1
GR - Grecia 1
GT - Guatemala 1
MK - Macedonia 1
ML - Mali 1
MN - Mongolia 1
NI - Nicaragua 1
Totale 17.408
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Città #
Fairfield 1.219
Ashburn 854
Woodbridge 796
Singapore 754
Chandler 661
Houston 550
Seattle 516
Hong Kong 490
Jacksonville 482
Cambridge 444
Nyköping 431
Wilmington 409
Ann Arbor 403
Dallas 394
Beijing 283
Bari 218
Dong Ket 188
Roxbury 175
Lawrence 165
Nanjing 165
New York 137
Boardman 127
Ho Chi Minh City 113
Des Moines 106
Princeton 106
Los Angeles 89
Brooklyn 87
Inglewood 70
São Paulo 62
San Diego 54
Buffalo 53
Hanoi 51
London 49
Munich 47
Rome 45
Santa Clara 43
Shenyang 43
Jakarta 41
Dublin 40
Vienna 38
Jiaxing 36
Nanchang 35
Hebei 34
Warsaw 32
Abidjan 31
Council Bluffs 31
Brussels 29
Dearborn 29
Nuremberg 28
Paris 28
Rio de Janeiro 28
Chicago 27
Frankfurt am Main 25
Pune 24
Changsha 23
Shanghai 23
Tianjin 23
Tokyo 23
Montreal 22
North Bergen 21
Helsinki 20
Moscow 20
Norwalk 20
San Francisco 19
Turku 19
Denver 17
Unterföhring 17
Columbus 15
Curitiba 15
Guayaquil 15
Redwood City 15
Toronto 15
Stockholm 14
The Dalles 14
Amsterdam 13
Belo Horizonte 13
Brasília 13
Guangzhou 13
Phoenix 13
Atlanta 12
Tashkent 12
Boston 11
Falls Church 11
Johannesburg 11
Langenzersdorf 11
Mexico City 11
Salt Lake City 11
Sorocaba 11
Ardabil 10
Haiphong 10
Manchester 10
Naples 10
Orem 10
Biên Hòa 9
Boydton 9
Fortaleza 9
Indiana 9
Milan 9
Poplar 9
Augusta 8
Totale 12.063
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Nome #
1-Aryl-4-[(1-tetralinyl)alkyl]piperazines: alkylamido and alkylamino derivatives. Synthesis, 5-HT1A receptor affinity, and selectivity. 3 211
1-(2-Methoxyphenyl)-4-alkylpiperazines: effect of the N-4 substituent on the affinity and selectivity for dopamine D4 receptor 194
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update 193
Arylpiperazine agonists of the serotonin 5-HT1A receptor preferentially activate cAMP signaling versus recruitment of β-arrestin-2 181
Activation of 5-HT7 receptor stimulates neurite elongation through mTOR, Cdc42 and actin filaments dynamics. 180
Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X Syndrome 171
5-HT7 receptor activation: procognitive and antiamnesic effects 170
An updated patent review on P-glycoprotein inhibitors (2011-2018) 166
Activation of 5-HT7 receptor by administration of its selective agonist, LP-211, modifies explorative-curiosity behavior in rats in two paradigms which differ in visuospatial parameters 164
Long-lasting beneficial effects of central serotonin receptor 7 stimulation in female mice modeling Rett syndrome. 161
1-Arylpiperazinic ligands of 5-HT7 receptor and use threreof 160
Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist 158
1-Aryl-4-[N-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)alkyl]piperazines and their analogues: influence of the stereochemistry of the tetrahydronaphthalen-1-yl nucleus on 5-HT1A receptor affinity and selectivity versus alpha1 and D2 receptors. 5 157
P-GP RADIOTRACER FOR IMAGING AS BIOMARKERS INVOLVED IN ONSET OF NEURODEGENERATIVE DISEASE 156
5 HT1A receptor, an old target for new therapeutic agents 154
A Benzopyrane derivative as P-glycoprotein stimulator: a potential agent to decrease beta-amyloid accumulation in Alzheimer’s disease 151
1-Substituted-4- 3-(1,2,3,4-tetrahydro-5- or 7-methoxynaphthalen-1-yl)propyl piperazines: influence of the N-1 piperazine substituent on 5-HT1A receptor affinity and selectivity versus D2 and alfa-1 receptors.Part 6 150
11C-Labeling of N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]arylcarboxamide derivatives and evaluation as potential radioligands for PET imaging of dopamine D3 receptors 149
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. 147
3-(1H-indol-3-yl)-2-[3-(4-nitrophenyl)ureido]propanamide enantiomers with human formyl-peptide receptor agonist activity: Molecular modeling of chiral recognition by FPR2. 146
Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and Behavior in a Mouse Model of Fragile X Syndrome 145
Cyclohexyl-substituted piperazine compounds 143
Functionalized Coumarine Fragment to Obtain Fluorescent and Selective P-Glycoprotein Ligands 139
POLYCYCLIC LIGANDS OF 5-HT7 RECEPTOR AND USE THEREOF 138
5-HT7 receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009) 135
Activatable fluorescent probes: a new concept in optical molecular imaging 133
Functional N-Formyl Peptide Receptor 2 (FPR2) Antagonists Based on the Ureidopropanamide Scaffold Have Potential To Protect Against Inflammation-Associated Oxidative Stress 132
Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: Synthesis and binding affinities for 5-HT7 and 5-HT1A receptors 131
Stimulation of the brain serotonin receptor 7 rescues mitochondrial dysfunction in female mice from two models of Rett syndrome 129
METHOD FOR DETERMINING FREE COPPER 129
Novel 3-(1H-indol-3-yl)-2-[3-(4-methoxyphenyl)ureido]propanamides as selective agonists of human formyl-peptide receptor 2. 127
Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder 127
Structure-activity relationship study towards non-peptidic positron emission tomography (PET) radiotracer for gastrin releasing peptide receptors: Development of [18F] (S)-3-(1H-indol-3-yl)-N-[1-[5-(2-fluoroethoxy)pyridin-2-yl]cyclohexylmethyl]-2-methyl-2-[3-(4-nitrophenyl)ureido]propionamide. 125
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters 122
Targets for Drug Therapy for Autism Spectrum Disorder: Challenges and Future Directions 122
5-HT1A and D-2 receptor affinity of o-methoxyphenyl derivatives with terminal benzamide fragment on N-4 alkyl chain. 2 121
Aurantiamide-related dipeptide derivatives are formyl peptide receptor 1 antagonists 121
The 5-HT7 receptor triggers cerebellar long-term synaptic depression via PKC-MAPK 121
Carbon-11 PB-12: an attempt to visualize the dopamine D4 receptor in the primate brain with positron emission tomography 120
ABC transporters in CSCs membranes as a novel target for treating tumor relapse 120
5-HT3 and 5-HT4 receptor affinities of naphtho[1,2-d]thiazole derivatives with various basic side chains 117
N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand 116
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments 116
LP-211, a selective 5-HT7receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats 115
Structural Determinants in the Binding of BB2 Receptor Ligands: In Silico, X-Ray and NMR Studies in PD176252 Analogues. 115
The brain-penetrant 5-HT7receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain 114
G-protein coupled receptors involved in the resolution of inflammation: Ligands and therapeutic perspectives 113
Interplay between Serotonin 5-HT1A and 5-HT7 Receptors in Depressive Disorders. 112
4-[omega-[4-arylpiperazin-1-yl]phenyl)imidazo[1,2-a]pyridine derivatives: fluorescent high-affinity dopamine D3 receptor ligands as potential probes for receptor visualization 112
Structural modifications of the serotonin 5-HT7 receptor agonist N -(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study 110
Microinjection of the 5-HT7 receptor antagonist SB-269970 into the rat brainstem and basal forebrain: Site-dependent effects on REM sleep 109
Guinea-pig ileum as ex vivo model useful to characterize ligands displaying Imidazoline I2 and Adrenergic alpha2 mixed activity: a preliminary study 109
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor 108
N-aryl- or N-alkylpiperazine derivatives: the role of N-substituent on sigma-1, sigma-2, 5-HT1A and D2 receptor affinity 108
Structural insights into serotonin receptor ligands polypharmacology 108
Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters 108
HPLC-UV and LC-MS/MS analysis to study formulation and long-term stability of some anticancer drugs in elastomeric pumps 108
Design and synthesis of new selective P-gp substrates and inhibitors. 107
Synthesis, radiolabeling and in vivo evaluation of [11C](R)-1-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]-3-(2-pyrazinyloxy)-2-propanol, a potential PET radioligand for the 5-HT7 receptor 105
2-(Aryloxy)ethylamine derivatives: ring opened congeners of long chain 1-arylpiperazines with high 5-HT1A receptor affinity and selectivity versus D2 and a1 receptors 105
5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment 105
The therapeutic potential of 5-HT1A receptors: a patent review. 104
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor. 104
The microRNA-29a Modulates Serotonin 5-HT7 Receptor Expression and Its Effects on Hippocampal Neuronal Morphology 104
Biomarkers for the early diagnosis of Alzheimer’s disease: the challenge of XXI century. 103
N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-phenyl-1-piperazinealkylamide derivatives, and therapeutic use thereof as 5-HT7 receptor ligands 103
Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. 103
The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. 103
EGFR tyrosine kinase inhibitors and multidrug resistance: perspectives 101
BEHAVIOURAL EFFECTS OF TWO NOVEL AGONISTS FOR SEROTONIN RECEPTOR 7 IN MICE 101
Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders 101
Design, synthesis, lipophilic properties, and binding affinities of potential ligands in positron emission tomography (PET) for visualization of brain dopamine D4 receptors. 101
A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites 101
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview. 101
Serotonin7 Receptors (5-HT7Rs) and their Ligands 100
Novel 4-(-4-Aryl)cyclohexyl-1-(2-pyridyl)piperazines as delta8-delta7 sterol isomerase ( Emopamil Binding Protein) selective ligands with antiprolifative activity 100
Systemic administration and local microinjection into the central nervous system of the 5-HT(7) receptor agonist LP-211 modify the sleep-wake cycle in the rat. 99
4-[omega-Tetralin-1-yl]-1-benzylpiperazines and related compounds as 5-HT1A/D-2 ligands 99
Novel agonists for serotonin 5-HT7 receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome 99
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212 99
Serotonin 5-HT7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons 98
Novel 64Cu Labeled RGD2-BBN Heterotrimers for PET Imaging of Prostate Cancer 97
Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. 95
Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice 95
Emotional and risk seeking behavior after prepuberal subchronic or adult acute stimulation of 5-HT7-Rs in naples high excitability rats. 95
Novel ureidopropanamide based N-formyl peptide receptor 2 (FPR2) agonists with potential application for central nervous system disorders characterized by neuroinflammation 95
Selective 5-HT7 receptor agonists LP 44 and LP 211 elicit an analgesic effect on formalin-induced orofacial pain in mice 94
The medicinal chemistry of 5-HT2C receptor ligands 92
Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas 92
International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function 92
Determination of 1-aryl-4propylpiperazine pKa values: the substituent on aryl modulates basicity 91
Increase of Capsaicin-Induced Trigeminal Fos-Like Immunoreactivity by 5-HT(7) Receptors. 91
Editorial 90
Percorsi formativi e figure professionali nella preparazione dei radiofarmaci 90
Synthesis and Biological Evaluation of Potential Positron Emission Tomography (PET) Ligands for Brain Visualization of Dopamine D3 Receptors. 89
The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways 89
Allosteric Modulators of Serotonin Receptors: A Medicinal Chemistry Survey 87
Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate 87
Small and innovative molecules as new strategy to revert MDR 87
Potentiation of capsaicin-induced neurogenic inflammation by 5-HT7 receptors in the rat hind paw: Involvement of calcitonin gen-related peptide 87
Totale 11.978
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Categoria #
all - tutte 76.831
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 76.831
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/20211.175 0 0 0 0 0 69 207 128 138 223 136 274
2021/20221.384 66 164 40 57 68 102 66 71 126 76 232 316
2022/20231.900 327 182 130 151 268 226 25 207 308 7 33 36
2023/2024708 53 116 38 33 50 153 21 22 53 28 27 114
2024/20253.242 121 26 279 127 94 231 320 288 177 140 492 947
2025/20263.879 939 431 727 813 665 304 0 0 0 0 0 0
Totale 17.883