Genetic risk for schizophrenia is determined by hundreds of genetic loci whose biological, functional, and clinical translation remain unclear. Since genes do not work in isolation, we hypothesized that schizophrenia risk could be parsed into co- regulated genetic pathways associated with systems-level brain function. Given that genetic variants related to the dopamine D2 receptor gene DRD2 are associated with schizophrenia and its imaging phenotypes, we explored the biological, functional, and clinical validity of a novel molecular pathway co-expressed with DRD2 in the human prefrontal cortex.
A co-expression gene set and associated polygenic score in relation to clinical response to antipsychotics
Bertolino A;Pergola G;Blasi G.
2017-01-01
Abstract
Genetic risk for schizophrenia is determined by hundreds of genetic loci whose biological, functional, and clinical translation remain unclear. Since genes do not work in isolation, we hypothesized that schizophrenia risk could be parsed into co- regulated genetic pathways associated with systems-level brain function. Given that genetic variants related to the dopamine D2 receptor gene DRD2 are associated with schizophrenia and its imaging phenotypes, we explored the biological, functional, and clinical validity of a novel molecular pathway co-expressed with DRD2 in the human prefrontal cortex.File in questo prodotto:
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